Gene Symbol: UFSP1
Description: UFM1 specific peptidase 1 (inactive)
Alias: UFSP, inactive Ufm1-specific protease 1, UFM1-specific peptidase 1 (non-functional)
Species: human
Products:     UFSP1

Top Publications

  1. Ha B, Jeon Y, Shin S, Tatsumi K, Komatsu M, Tanaka K, et al. Structure of ubiquitin-fold modifier 1-specific protease UfSP2. J Biol Chem. 2011;286:10248-57 pubmed publisher
    ..The C-terminal catalytic domain is similar to UfSP1 with Cys(294), Asp(418), His(420), Tyr(282), and a regulatory loop participating in catalysis...
  2. Liu H, Gong M, French B, Li J, Tillman B, French S. Mallory-Denk Body (MDB) formation modulates Ufmylation expression epigenetically in alcoholic hepatitis (AH) and non-alcoholic steatohepatitis (NASH). Exp Mol Pathol. 2014;97:477-83 pubmed publisher
    ..Betaine significantly prevented transcript silencing of Ufm1, Uba5 and UfSP1 where MDBs developed and also prevented the increased expression of FAT10 and LMP7 caused by DDC re-fed mice...
  3. Sajuthi S, Sharma N, Chou J, Palmer N, McWilliams D, Beal J, et al. Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity. Hum Genet. 2016;135:869-80 pubmed publisher
    ..Mining GWAS databases revealed association of cis-eSNPs for more than 50 genes with T2D (e.g. PIK3C2A, RBMS1, UFSP1), gluco-metabolic phenotypes (e.g. INPP5E, SNX17, ERAP2, FN3KRP), and obesity (e.g. POMC, CPEB4)...
  4. Kang S, Kim G, Seong M, Baek S, Seol J, Bang O, et al. Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. J Biol Chem. 2007;282:5256-62 pubmed
    ..Here we report the isolation, cloning, and characterization of two novel mouse Ufm1-specific proteases, named UfSP1 and UfSP2...
  5. Ha B, Ahn H, Kang S, Tanaka K, Chung C, Kim E. Structural basis for Ufm1 processing by UfSP1. J Biol Chem. 2008;283:14893-900 pubmed publisher
    ..Two novel proteases, named UfSP1 and UfSP2, have been shown to be responsible for the release of Ufm1 from Ufm1-conjugated cellular proteins as ..
  6. Ha B, Kim K, Yoo H, Lee W, EunKyeong Kim E. The MPN domain of Caenorhabditis elegans UfSP modulates both substrate recognition and deufmylation activity. Biochem Biophys Res Commun. 2016;476:450-456 pubmed publisher
    ..There are two forms: UfSP1 and UfSP2, the later with an additional domain at the N-terminus...
  7. Kim K, Ha B, Kim E. Structural basis for Ufm1 recognition by UfSP. FEBS Lett. 2017;: pubmed publisher
    ..Here, we report a structural basis for the recognition of Ufm1 by the Ufm1-specific protease (UfSP), both from C. elegans...
  8. Wilson M, Riemer C, Martindale D, Schnupf P, Boright A, Cheung T, et al. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. Nucleic Acids Res. 2001;29:1352-65 pubmed
    ..Our mouse-human comparison can be viewed at http://web.uvic.ca/~bioweb/laj.html. Laj is available at http://bio.cse.psu.edu/, along with online documentation and additional examples of annotated genomic regions. ..
  9. Eijgelsheim M, Newton Cheh C, Sotoodehnia N, de Bakker P, Müller M, Morrison A, et al. Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet. 2010;19:3885-94 pubmed publisher
    ..MYH7; 12p12 near SOX5, c12orf67, BCAT1, LRMP and CASC1; 6q22 near SLC35F1, PLN and c6orf204; 7q22 near SLC12A9 and UfSp1; and 11q12 near FADS1...

More Information


  1. Huang J, Sabater Lleal M, Asselbergs F, Tregouet D, Shin S, Ding J, et al. Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. Blood. 2012;120:4873-81 pubmed publisher
    ..1. In summary, SNPs in SERPINE1 and ARNTL and an SNP associated with the expression of MUC3 were robustly associated with circulating levels of PAI-1. ..