UBTF

Summary

Gene Symbol: UBTF
Description: upstream binding transcription factor
Alias: CONDBA, NOR-90, UBF, UBF-1, UBF1, UBF2, nucleolar transcription factor 1, 90-kDa nucleolus organizer region autoantigen, autoantigen NOR-90, upstream binding transcription factor, RNA polymerase I
Species: human
Products:     UBTF

Top Publications

  1. O Mahony D, Rothblum L. Identification of two forms of the RNA polymerase I transcription factor UBF. Proc Natl Acad Sci U S A. 1991;88:3180-4 pubmed
    The structure of the rat homologue of the RNA polymerase I transcription factor UBF was investigated...
  2. Voit R, Hoffmann M, Grummt I. Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF. EMBO J. 1999;18:1891-9 pubmed
    ..analyzed the activity and phosphorylation pattern of the nucleolar transcription factor upstream binding factor (UBF)...
  3. Shimono K, Shimono Y, Shimokata K, Ishiguro N, Takahashi M. Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription. J Biol Chem. 2005;280:39436-47 pubmed
    ..of a nucleosome remodeling and deacetylase (NuRD) complex, RET finger protein (RFP), and upstream binding factor (UBF) were associated with MCRS1...
  4. Mais C, Wright J, Prieto J, Raggett S, McStay B. UBF-binding site arrays form pseudo-NORs and sequester the RNA polymerase I transcription machinery. Genes Dev. 2005;19:50-64 pubmed
    ..The architectural RNA polymerase I (pol I) transcription factor UBF binds extensively across rDNA throughout the cell cycle...
  5. Hanada K, Song C, Yamamoto K, Yano K, Maeda Y, Yamaguchi K, et al. RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription. EMBO J. 1996;15:2217-26 pubmed
    ..Moreover, PAF53 interacted with mouse UBF in vitro, as revealed by Far-Western blotting and GST pull down assays...
  6. Hannan K, Hannan R, Smith S, Jefferson L, Lun M, Rothblum L. Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1. Oncogene. 2000;19:4988-99 pubmed
    ..gene (Rb) functions as a regulator of transcription by RNA polymerase I (rDNA transcription) by inhibiting UBF-mediated transcription...
  7. Jantzen H, Admon A, Bell S, Tjian R. Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins. Nature. 1990;344:830-6 pubmed
    The eukaryotic upstream binding factor (UBF), recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor, SL1...
  8. Bell S, Learned R, Jantzen H, Tjian R. Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis. Science. 1988;241:1192-7 pubmed
    ..distinct control elements (UCE and core) both of which are recognized by the sequence-specific DNA binding protein UBF1, which has now been purified to apparent homogeneity...
  9. Voit R, Kuhn A, Sander E, Grummt I. Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF. Nucleic Acids Res. 1995;23:2593-9 pubmed
    The nucleolar factor UBF is phosphorylated by casein kinase II (CKII) at serine residues within the C-terminal acidic domain which is required for transcription activation...

More Information

Publications146 found, 100 shown here

  1. Zhai W, Comai L. Repression of RNA polymerase I transcription by the tumor suppressor p53. Mol Cell Biol. 2000;20:5930-8 pubmed
    ..Our biochemical analysis shows that p53 prevents the interaction between SL1 and UBF. Protein-protein interaction assays indicate that p53 binds to SL1, and this interaction is mostly mediated by ..
  2. Pelletier G, Stefanovsky V, Faubladier M, Hirschler Laszkiewicz I, Savard J, Rothblum L, et al. Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription. Mol Cell. 2000;6:1059-66 pubmed
    RNA polymerase I (PolI) transcription is activated by the HMG box architectural factor UBF, which loops approximately 140 bp of DNA into the enhancesome, necessitating major chromatin remodeling...
  3. Voit R, Grummt I. Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription. Proc Natl Acad Sci U S A. 2001;98:13631-6 pubmed
    Modulation of the activity of the upstream binding factor (UBF) plays a key role in cell cycle-dependent regulation of rRNA synthesis...
  4. Sun H, Tu X, Prisco M, Wu A, Casiburi I, Baserga R. Insulin-like growth factor I receptor signaling and nuclear translocation of insulin receptor substrates 1 and 2. Mol Endocrinol. 2003;17:472-86 pubmed
    ..The interaction of nuclear IRS proteins with upstream binding factor 1 constitutes the first direct link of these proteins with the ribosomal DNA transcription machinery. ..
  5. Grandori C, Gomez Roman N, Felton Edkins Z, Ngouenet C, Galloway D, Eisenman R, et al. c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. Nat Cell Biol. 2005;7:311-8 pubmed
    ..We propose that stimulation of rRNA synthesis by c-Myc is a key pathway driving cell growth and tumorigenesis. ..
  6. Cavanaugh A, Hempel W, Taylor L, Rogalsky V, Todorov G, Rothblum L. Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product. Nature. 1995;374:177-80 pubmed
    ..a functional Rb pocket; and (4) Rb specifically inhibits the activity of the RNA polymerase I transcription factor UBF (upstream binding factor) in vitro...
  7. Stefanovsky V, Pelletier G, Hannan R, Gagnon Kugler T, Rothblum L, Moss T. An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF. Mol Cell. 2001;8:1063-73 pubmed
    ..ERK1/2 was found to phosphorylate the architectural transcription factor UBF at amino acids 117 and 201 within HMG boxes 1 and 2, preventing their interaction with DNA...
  8. Halkidou K, Logan I, Cook S, Neal D, Robson C. Putative involvement of the histone acetyltransferase Tip60 in ribosomal gene transcription. Nucleic Acids Res. 2004;32:1654-65 pubmed
    ..we propose a model based on which Tip60 is actively involved in ribosomal gene transcription through acetylation of UBF, a ribosomal specific transcription factor, as well as through its direct recruitment to the human ribosomal gene ..
  9. Friedrich J, Panov K, Cabart P, Russell J, Zomerdijk J. TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter. J Biol Chem. 2005;280:29551-8 pubmed
    ..We describe key findings for the roles of essential transcription factor SL1 and activator upstream binding factor (UBF)...
  10. Young D, Hassan M, Pratap J, Galindo M, Zaidi S, Lee S, et al. Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2. Nature. 2007;445:442-6 pubmed
    ..Runx2 chromosomal foci are associated with open chromatin, co-localize with the RNA Pol I transcription factor UBF1, and undergo transition into nucleoli at sites of rRNA synthesis during interphase...
  11. Prieto J, McStay B. Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. Genes Dev. 2007;21:2041-54 pubmed
    ..The pol I transcription factor UBF binds extensively across rDNA throughout the cell cycle, resulting in a specialized form of chromatin that is the ..
  12. Chen J, Lobb I, Morin P, Novo S, Simpson J, Kennerknecht K, et al. Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway. Nucleic Acids Res. 2018;46:6188-6205 pubmed publisher
    ..It is mimicked by CDK4 inhibition and is dependent upon a novel pathway involving UBF/p14ARF and S44 of the protein...
  13. Lemley C, Hart C, Lemire R, King E, Hopper R, Park S, et al. Maternal nutrient restriction alters uterine artery hemodynamics and placentome vascular density in Bos indicus and Bos taurus. J Anim Sci. 2018;96:4823-4834 pubmed publisher
    The objective was to examine uterine artery blood flow (UBF) as well as macroscopic and microscopic placentome vascular density in nutrient-restricted Angus and Brahman heifers...
  14. Dalmizrak O, Wu A, Chen J, Sun H, Utama F, Zambelli D, et al. Insulin receptor substrate-1 regulates the transformed phenotype of BT-20 human mammary cancer cells. Cancer Res. 2007;67:2124-30 pubmed
    ..Targeting of IRS-1 could be effective in inhibiting the proliferation of mammary cancer cells. ..
  15. Oh H, An C, Yoo N, Lee S. Frameshift mutations of TAF1C gene, a core component for transcription by RNA polymerase I, and its regional heterogeneity in gastric and colorectal cancers. Pathology. 2015;47:101-4 pubmed publisher
    ..p53 tumour suppressor inhibits rRNA transcription by blocking TAF1C-UBF interaction, but alterations of TAF1C itself in tumorigenesis remain unknown...
  16. Pfister A, Keil M, Kühl M. The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway. J Biol Chem. 2015;290:10905-18 pubmed publisher
    ..PPAN depletion induces NPM and upstream-binding factor (UBF) degradation, which is independent of caspases...
  17. Gonyo P, Bergom C, Brandt A, Tsaih S, Sun Y, Bigley T, et al. SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression. Oncogene. 2017;36:6873-6883 pubmed publisher
    ..We show that nucleolar SmgGDS interacts with the RNA polymerase I transcription factor upstream binding factor (UBF)...
  18. Brehm M, Wundenberg T, Williams J, Mayr G, Shears S. A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA. J Cell Sci. 2013;126:437-44 pubmed publisher
    ..with three proteins that regulate rRNA synthesis: protein kinase CK2, TCOF1 and upstream-binding-factor (UBF)...
  19. Salomon Kent R, Marom R, John S, Dundr M, Schiltz L, Gutierrez J, et al. New Face for Chromatin-Related Mesenchymal Modulator: n-CHD9 Localizes to Nucleoli and Interacts With Ribosomal Genes. J Cell Physiol. 2015;230:2270-80 pubmed publisher
    ..the nucleolar CHD9 (n-CHD9) that is dynamically associated with Pol I, fibrillarin, and upstream binding factor (UBF) in the nucleoli, as shown by imaging and molecular approaches...
  20. Hamdane N, Herdman C, Mars J, Stefanovsky V, Tremblay M, Moss T. Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells. Oncotarget. 2015;6:27519-36 pubmed publisher
    Cisplatin-DNA adducts act as strong decoys for the Upstream Binding Factor UBF (UBTF) and have been shown to inhibit transcription of the ribosomal RNA genes by RNA polymerase I...
  21. Lin C, Yeh N. Treacle recruits RNA polymerase I complex to the nucleolus that is independent of UBF. Biochem Biophys Res Commun. 2009;386:396-401 pubmed publisher
    ..Treacle associates with upstream binding factor (UBF) to regulate rRNA gene (rDNA) transcription, but the precise mechanisms mediated by treacle remain elusive...
  22. Qin Y, Han B, Cao Y, Wang T. Impact of substrate concentration on anammox-UBF reactors start-up. Bioresour Technol. 2017;239:422-429 pubmed publisher
    Two up-flow blanket filter (UBF) reactors were employed to treat synthetic wastewater with different substrate concentrations and nitrogen load rates (NLR) for 178days. During days 0-60, higher influent NLR of R2 (0.21-0...
  23. Marsh K, Saraf I, Hocart C, Youngentob K, Singh I, Foley W. Occurrence and distribution of unsubstituted B-ring flavanones in Eucalyptus foliage. Phytochemistry. 2019;160:31-39 pubmed publisher
    ..We found large variation in the total UBF concentration both between and within species...
  24. Kasahara M, Ichinohe T, Okamoto S, Okada R, Kanbe H, Matsuura N. Concomitant administration of nitrous oxide and remifentanil reduces oral tissue blood flow without decreasing blood pressure during sevoflurane anesthesia in rabbits. J Anesth. 2015;29:421-425 pubmed publisher
    ..mandibular bone marrow blood flow (BBF), masseter muscle blood flow (MBF), upper alveolar tissue blood flow (UBF), and lower alveolar tissue blood flow (LBF) were recorded in the absence of all test agents and after ..
  25. Sun X, Chen H, Deng Z, Hu B, Luo H, Zeng X, et al. The Warsaw breakage syndrome-related protein DDX11 is required for ribosomal RNA synthesis and embryonic development. Hum Mol Genet. 2015;24:4901-15 pubmed publisher
    ..binds to hypomethylated active ribosomal DNA (rDNA) gene loci, where it interacts with upstream binding factor (UBF) and the RNA polymerase I (Pol I)...
  26. Koné M, Fleurot R, Chebrout M, Debey P, Beaujean N, Bonnet Garnier A. Three-Dimensional Distribution of UBF and Nopp140 in Relationship to Ribosomal DNA Transcription During Mouse Preimplantation Development. Biol Reprod. 2016;94:95 pubmed publisher
    ..study, we analyzed nucleologenesis during mouse early embryonic development using 3D-immunofluorescent detection of UBF and Nopp140, two proteins associated with different nucleolar compartments...
  27. Lafita Navarro M, Blanco R, Mata Garrido J, Liaño Pons J, Tapia O, García Gutiérrez L, et al. MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis. Oncotarget. 2016;7:69536-69548 pubmed publisher
    ..The nucleolar localization of MXD1 was confirmed by co-localization with UBF. Co-immunoprecipitation experiments showed that MXD1 interacted with UBF and proximity ligase assays revealed that ..
  28. Morovic M, Strejcek F, Nakagawa S, Deshmukh R, Murin M, Benc M, et al. Mouse oocytes nucleoli rescue embryonic development of porcine enucleolated oocytes. Zygote. 2017;:1-11 pubmed publisher
    ..by autoradiography, transmission electron microscopy (TEM) and immunofluorescence (C23 and upstream binding factor (UBF))...
  29. Rong H, Li Y, Shi X, Zhang X, Gao Y, Dai H, et al. Structure of human upstream binding factor HMG box 5 and site for binding of the cell-cycle regulatory factor TAF1. Acta Crystallogr D Biol Crystallogr. 2007;63:730-7 pubmed
    ..Based on these experimental data, possible sites in hUBF HMG box 5 that may interact with the first bromodomain of TAF1 were proposed. ..
  30. Tsai Y, Greco T, Boonmee A, Miteva Y, Cristea I. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Mol Cell Proteomics. 2012;11:M111.015156 pubmed publisher
  31. Kim B, Kwon H, Sohn E, Hwang S, Kwon O, Kim S. Activation of caspases and inhibition of ribosome biogenesis mediate antitumor activity of Chijongdan in A549 non-small lung cancer cells. BMC Complement Altern Med. 2014;14:420 pubmed publisher
    ..Chijongdan suppressed the expression of ribosomal biogenesis related proteins such as upstream binding factor (UBF), Fibrillarin, NPM (B23) and Importin-7 (IPO7) and conversely pan-caspase inhibitor Z--VAD-FMK reversed the ..
  32. Garcia Esparcia P, Hernández Ortega K, Koneti A, Gil L, Delgado Morales R, Castaño E, et al. Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson's disease. Acta Neuropathol Commun. 2015;3:76 pubmed publisher
    ..proteins nucleolin (NCL), nucleophosmin (NPM1), nucleoplasmin 3 (NPM3) and upstream binding transcription factor (UBF), decreased NPM1 but not NPM3 nucleolar protein immunostaining in remaining neurons; diminished 18S rRNA, 28S rRNA; ..
  33. Kong R, Zhang L, Hu L, Peng Q, Han W, Du X, et al. hALP, a novel transcriptional U three protein (t-UTP), activates RNA polymerase I transcription by binding and acetylating the upstream binding factor (UBF). J Biol Chem. 2011;286:7139-48 pubmed publisher
    ..Immunoprecipitation and GST pulldown experiments showed that hALP binds the upstream binding factor (UBF) in vivo and in vitro...
  34. Hamdane N, Stefanovsky V, Tremblay M, Németh A, Paquet E, Lessard F, et al. Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor body. PLoS Genet. 2014;10:e1004505 pubmed publisher
    Upstream Binding Factor (UBF) is a unique multi-HMGB-box protein first identified as a co-factor in RNA polymerase I (RPI/PolI) transcription...
  35. Hamdane N, Tremblay M, Dillinger S, Stefanovsky V, Nemeth A, Moss T. Disruption of the UBF gene induces aberrant somatic nucleolar bodies and disrupts embryo nucleolar precursor bodies. Gene. 2017;612:5-11 pubmed publisher
    ..We found that disruption of the mouse Upstream Binding Factor (UBF (UBTF)) gene caused disassembly of somatic nucleoli and the accumulation of the key rRNA gene transcription factors into ..
  36. Cox B, Williams C, Rosenfeld C. Angiotensin II indirectly vasoconstricts the ovine uterine circulation. Am J Physiol Regul Integr Comp Physiol. 2000;278:R337-44 pubmed
    ..001) increased arterial pressure (MAP) and UVR and decreased uterine blood flow (UBF) in pregnant and nonpregnant ewes; however, nonpregnant responses exceeded pregnant (P < 0.001)...
  37. Xu Y, Yang W, Wu J, Shi Y. Solution structure of the first HMG box domain in human upstream binding factor. Biochemistry. 2002;41:5415-20 pubmed
    ..The short arm is rigid due to extensive hydrophobic interaction between helix 1 and helix 2, while the long arm is less rigid. ..
  38. Esteller Vico A, Liu I, Vaughan B, Steffey E, Brosnan R. Effects of vascular elastosis on uterine blood flow and perfusion in anesthetized mares. Theriogenology. 2015;83:988-94 pubmed publisher
    In the uterus of the mare, data obtained using transrectal Doppler ultrasonography indicate that uterine blood flow (UBF) is dynamic and changes throughout the estrous cycle...
  39. Woolnough J, Atwood B, Liu Z, Zhao R, Giles K. The Regulation of rRNA Gene Transcription during Directed Differentiation of Human Embryonic Stem Cells. PLoS ONE. 2016;11:e0157276 pubmed publisher
    ..The reduction in rRNA synthesis is concomitant with dissociation of the Pol I transcription factor, UBTF, from the rRNA gene promoter and precedes any increase to heterochromatin throughout the rRNA gene...
  40. Cai S, Liu X, Zhang C, Xing B, Du X. Autoacetylation of NAT10 is critical for its function in rRNA transcription activation. Biochem Biophys Res Commun. 2017;483:624-629 pubmed publisher
    ..K426R mutant of NAT10 fails to activate rRNA transcription. NAT10 K426R loses its capability of acetylating UBF though it still binds UBF, which fails to recruit PAF53 and RNA polymerase I to rDNA, eventually resulting in ..
  41. Patterson K, Roberts Thomson P, Lester S, Tan J, Hakendorf P, Rischmueller M, et al. Interpretation of an Extended Autoantibody Profile in a Well-Characterized Australian Systemic Sclerosis (Scleroderma) Cohort Using Principal Components Analysis. Arthritis Rheumatol. 2015;67:3234-44 pubmed publisher
    ..Subclassification and disease stratification using autoantibodies may have clinical utility, particularly in early disease. ..
  42. Zhu W, Xu C, Zhang J, He H, Wu K, Zhang L, et al. Gene-based GWAS analysis for consecutive studies of GEFOS. Osteoporos Int. 2018;29:2645-2658 pubmed publisher
    ..Among these BMD-associated genes, three novel genes (UBTF, AAAS, and C11orf58) were partially validated at the gene expression level...
  43. Tchurikov N, Yudkin D, Gorbacheva M, Kulemzina A, Grischenko I, Fedoseeva D, et al. Hot spots of DNA double-strand breaks in human rDNA units are produced in vivo. Sci Rep. 2016;6:25866 pubmed publisher
    ..that only some portion of rDNA clusters possess γ-H2AX foci and that all γ-H2AX foci co-localize with UBF-1 binding sites, which strongly suggests that only active rDNA units possess the hot spots of DSBs...
  44. Kopp K, Gasiorowski J, Chen D, Gilmore R, Norton J, Wang C, et al. Pol I transcription and pre-rRNA processing are coordinated in a transcription-dependent manner in mammalian cells. Mol Biol Cell. 2007;18:394-403 pubmed
    ..We found that pol I transcription factor UBF interacts with pre-rRNA processing factors as analyzed by immunoprecipitations, and the association depends on ..
  45. Yu F, Shen X, Fan L, Yu Z. Analysis of histone modifications at human ribosomal DNA in liver cancer cell. Sci Rep. 2015;5:18100 pubmed publisher
    ..Furtherly, we studied whether UBF could affect histone modification markers and CTCF at rDNA in human liver cancer cell...
  46. Anyasi T, Jideani A, Mchau G. Phenolics and essential mineral profile of organic acid pretreated unripe banana flour. Food Res Int. 2018;104:100-109 pubmed publisher
    ..study assayed the essential macro and trace minerals as well as phenolic compounds present in unripe banana flour (UBF) obtained from the pulp of four different cultivars...
  47. Koiwai K, Noma S, Takahashi Y, Hayano T, Maezawa S, Kouda K, et al. TdIF2 is a nucleolar protein that promotes rRNA gene promoter activity. Genes Cells. 2011;16:748-64 pubmed publisher
    ..In addition, TdIF2 promotes upstream binding factor (UBF) acetylation in vivo...
  48. Figueiredo V, Caldow M, Massie V, Markworth J, Cameron Smith D, Blazevich A. Ribosome biogenesis adaptation in resistance training-induced human skeletal muscle hypertrophy. Am J Physiol Endocrinol Metab. 2015;309:E72-83 pubmed publisher
    ..b>UBF was the only protein found to be highly phosphorylated at rest after 8 wk of training...
  49. Jahani Asl A, Cheng C, Zhang C, Bonni A. Pathogenesis of Börjeson-Forssman-Lehmann syndrome: Insights from PHF6 function. Neurobiol Dis. 2016;96:227-235 pubmed publisher
    ..PHF6 also interacts with the NuRD chromatin remodeling complex and with the nucleolar transcriptional regulator UBF, though the biological role of these interactions remains to be characterized...
  50. Edvardson S, Nicolae C, Agrawal P, Mignot C, Payne K, Prasad A, et al. Heterozygous De Novo UBTF Gain-of-Function Variant Is Associated with Neurodegeneration in Childhood. Am J Hum Genet. 2017;101:267-273 pubmed publisher
    ..5-7 years, we identified a heterozygous variant, c.628G>A in UBTF, encoding p.Glu210Lys in UBF, which occurred de novo in all cases...
  51. Miller G, Panov K, Friedrich J, Trinkle Mulcahy L, Lamond A, Zomerdijk J. hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters. EMBO J. 2001;20:1373-82 pubmed
    ..We conclude that hRRN3 functions to recruit initiation-competent Pol I to rRNA gene promoters. The essential role for hRRN3 in linking Pol I to SL1 suggests a mechanism for growth control of Pol I transcription. ..
  52. Johnston R, D Costa Z, Ray S, Gorski J, Harkin D, Mullan P, et al. The identification of a novel role for BRCA1 in regulating RNA polymerase I transcription. Oncotarget. 2016;7:68097-68110 pubmed publisher
    ..We demonstrate that BRCA1 interacts directly with the basal Pol-I transcription factors; upstream binding factor (UBF), selectivity factor-1 (SL1) as well as interacting with RNA Pol-I itself...
  53. Zhang Y, Forys J, Miceli A, Gwinn A, Weber J. Identification of DHX33 as a mediator of rRNA synthesis and cell growth. Mol Cell Biol. 2011;31:4676-91 pubmed publisher
    ..with ribosomal DNA (rDNA) loci, where it interacts with the RNA Pol I transcription factor upstream binding factor (UBF)...
  54. Rosenfeld C, White R, Roy T, Cox B. Calcium-activated potassium channels and nitric oxide coregulate estrogen-induced vasodilation. Am J Physiol Heart Circ Physiol. 2000;279:H319-28 pubmed
    ..001) in heart rate (13%) and contralateral uterine blood flow (UBF, approximately 5-fold) were unaffected...
  55. Feng W, Yonezawa M, Ye J, Jenuwein T, Grummt I. PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nat Struct Mol Biol. 2010;17:445-50 pubmed publisher
  56. Anyasi T, Jideani A, Mchau G. Effect of organic acid pretreatment on some physical, functional and antioxidant properties of flour obtained from three unripe banana cultivars. Food Chem. 2015;172:515-22 pubmed publisher
    Unripe banana flour (UBF) obtained from organic acid pretreatment of pulp from three non-commercial cultivars were profiled for physical, functional and antioxidant properties. UBF showed marked significant differences (p<0...
  57. Ali S, Dobson J, Lian J, Stein J, Van Wijnen A, Zaidi S, et al. A RUNX2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation. J Cell Sci. 2012;125:2732-9 pubmed publisher
    ..with active rRNA-encoding genes and causes deacetylation of the protein upstream binding factor (UBF, also known as UBTF)...
  58. Westdorp K, Sand A, Moorman N, Terhune S. Cytomegalovirus Late Protein pUL31 Alters Pre-rRNA Expression and Nuclear Organization during Infection. J Virol. 2017;91: pubmed publisher
    ..During infection, pUL31 colocalizes with nucleolin but not the transcriptional activator, UBF. In the absence of pUL31, CMV fails to reorganize nucleolin and UBF and exhibits a replication defect at a low ..
  59. Coutts A, Munro S, La Thangue N. Functional interplay between E2F7 and ribosomal rRNA gene transcription regulates protein synthesis. Cell Death Dis. 2018;9:577 pubmed publisher
    ..b>UBF (upstream binding factor) is one of the main Pol I transcription factors located in the nucleolus that activates ..
  60. Ayrault O, Andrique L, Fauvin D, Eymin B, Gazzeri S, Seite P. Human tumor suppressor p14ARF negatively regulates rRNA transcription and inhibits UBF1 transcription factor phosphorylation. Oncogene. 2006;25:7577-86 pubmed
    ..interactions between p14ARF and the transcription machinery proteins demonstrated that the upstream binding factor (UBF), required for the initiation of the transcriptional complex, was a new partner of the p14ARF protein...
  61. Sanij E, Diesch J, Lesmana A, Poortinga G, Hein N, Lidgerwood G, et al. A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes. Genome Res. 2015;25:201-12 pubmed publisher
    ..Upstream binding transcription factor (UBTF, also called UBF) is thought to function exclusively in RNA polymerase I (Pol I)-specific transcription of the ..
  62. Zhao Q, Wu Y, Shan Z, Bai G, Wang Z, Hu J, et al. Serum starvation-induced cell cycle synchronization stimulated mouse rDNA transcription reactivation during somatic cell reprogramming into iPSCs. Stem Cell Res Ther. 2016;7:112 pubmed publisher
    ..Both MEFs and serum-refeeding MEFs (S-MEFs) were reprogrammed to a pluripotent state. rDNA-related genes, UBF proteins, and rDNA methylation levels were detected during the MEF and S-MEF cell reprogramming process...
  63. Elmetwally M, Bollwein H. Uterine blood flow in sheep and goats during the peri-parturient period assessed by transrectal Doppler sonography. Anim Reprod Sci. 2017;176:32-39 pubmed publisher
    The aim of the present study was to evaluate uterine blood flow (UBF) during the postpartum period in small ruminants. The study involved measures of UBF in 5 ewes and 5 goats during the first 4 weeks after parturition...
  64. Desforges M, Rogue A, Pearson N, Rossi C, Olearo E, Forster R, et al. In vitro human placental studies to support an adenovirus-mediated VEGF-D?N?C maternal gene therapy for the treatment of severe early-onset fetal growth restriction. Hum Gene Ther Clin Dev. 2017;: pubmed publisher
    ..Reduced uterine blood flow (UBF) is one cause...
  65. Rakers F, Bischoff S, Schiffner R, Haase M, Rupprecht S, Kiehntopf M, et al. Role of catecholamines in maternal-fetal stress transfer in sheep. Am J Obstet Gynecol. 2015;213:684.e1-9 pubmed publisher
    ..catecholamines also transfer psychosocial stress indirectly to the fetus by decreasing uterine blood flow (UBF) and increasing fetal anaerobic metabolism and stress hormones...
  66. Bao Y, Liu Z, Zhang J, Wu J, Shi Y. 1H, 13C and 15N resonance assignments and secondary structure of the human PHF6-ePHD1 domain. Biomol NMR Assign. 2016;10:1-4 pubmed publisher
    ..ePHD (ePHD1) of PHF6 is involved in its nucleolus localization, directly interacts with upstream binding factor (UBF) and suppresses rRNA transcription...
  67. Hassan M, Sattar A, Bilal M, Avais M, Ahmad N. Evaluation of changes in blood flow of the uterine artery by Doppler ultrasonography during the estrous cycle in lactating Bos indicus cows. Anim Reprod Sci. 2017;184:78-85 pubmed publisher
    The objective of this study was to evaluate the changes in uterine blood flow (UBF) based on the resistance index (RI) and the pulsatility index (PI) by Doppler ultrasonography throughout the estrous cycle in lactating Sahiwal cows (n=9)...
  68. Fyfe J, Bishop D, Bartlett J, Hanson E, Anderson M, Garnham A, et al. Enhanced skeletal muscle ribosome biogenesis, yet attenuated mTORC1 and ribosome biogenesis-related signalling, following short-term concurrent versus single-mode resistance training. Sci Rep. 2018;8:560 pubmed publisher
    ..both mTORC1 (p70S6K1 and rps6 phosphorylation) and 45S pre-rRNA transcription-related signalling (TIF-1A and UBF phosphorylation) versus concurrent training...
  69. Lee J, Hwang Y, Ryu H, Kowall N, Ryu H. Nucleolar dysfunction in Huntington's disease. Biochim Biophys Acta. 2014;1842:785-90 pubmed publisher
    ..In this review, we discuss about how post-translational modifications of upstream binding factor (UBF) are affected by histone acetyltransferase and histone methyltransferase and involved in the transcriptional ..
  70. Ouellet Lavallée G, Pearson A. Upstream binding factor inhibits herpes simplex virus replication. Virology. 2015;483:108-16 pubmed publisher
    ..induces changes to the host cell nucleus including relocalization of the cellular protein Upstream Binding Factor (UBF) from the nucleolus to viral replication compartments (VRCs)...
  71. Rajarajacholan U, Thalappilly S, Riabowol K. ING1 regulates rRNA levels by altering nucleolar chromatin structure and mTOR localization. Nucleic Acids Res. 2017;45:1776-1792 pubmed publisher
    ..ING1 inhibits rDNA transcription by inhibiting UBF activity and its interaction with mTOR...
  72. Wu M, Wei W, Chen J, Cong R, Shi T, Bouvet P, et al. Acidic domains differentially read histone H3 lysine 4 methylation status and are widely present in chromatin-associated proteins. Sci China Life Sci. 2017;60:138-151 pubmed publisher
    ..proteins including nucleophosmin (NPM1), pp32, SET/TAF1?, nucleolin (NCL) and upstream binding factor (UBF) are novel H3K4me2-binding proteins...
  73. Wang D, Zhang J, Jin X, Wu J, Shi Y. Investigation of the structural stability of hUBF HMG box 5 by native-state hydrogen exchange. Biochemistry. 2007;46:1293-302 pubmed
    ..The NHX data have also allowed the local, subglobal, and global unfolding structures of hUBF HMG box 5 to be dissected, and common global and subglobal unfolding units were successfully detected. ..
  74. Shishova K, Khodarovich Y, Lavrentyeva E, Zatsepina O. High-resolution microscopy of active ribosomal genes and key members of the rRNA processing machinery inside nucleolus-like bodies of fully-grown mouse oocytes. Exp Cell Res. 2015;337:208-18 pubmed publisher
    ..We further showed that in the NLB mass of NSN-oocytes, distribution of active rDNA, RNA polymerase I (UBF) and rRNA processing (fibrillarin) protein factors, U3 snoRNA, pre-rRNAs and 18S/28S rRNAs is remarkably similar to ..
  75. Van Sluis M, van Vuuren C, McStay B. The Relationship Between Human Nucleolar Organizer Regions and Nucleoli, Probed by 3D-ImmunoFISH. Methods Mol Biol. 2016;1455:3-14 pubmed publisher
    ..Antibodies against UBF recognize transcriptionally active rDNA/NORs and NOP52 antibodies provide a convenient way of visualizing the ..
  76. Père M, Etienne M. Nutrient uptake of the uterus during the last third of pregnancy in sows: Effects of litter size, gestation stage and maternal glycemia. Anim Reprod Sci. 2018;188:101-113 pubmed publisher
    ..71 vs. 1.31kg, P=0.04) in the LIG than in the CTR sows. Treatment did not affect uterine blood flow (UBF), but UBF/fetus was greater for the LIG treatment (0.57 vs. 0.32L/min, P=0.003)...
  77. Yang W, Xu Y, Wu J, Zeng W, Shi Y. Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor. Biochemistry. 2003;42:1930-8 pubmed
    ..These differences may contribute to the loss of the DNA binding ability of box 5. ..
  78. Lee D, An J, Park Y, Liaw H, Woodgate R, Park J, et al. SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner. Proc Natl Acad Sci U S A. 2017;114:E3424-E3433 pubmed publisher
    ..Taken together, we provide evidence that SHPRH functions in rRNA transcription through its interaction with histone H3 in a mammalian target of rapamycin (mTOR)-dependent manner. ..
  79. Edgar C, Singh H, Obopilwe E, Voss A, DiVenere J, Tassavor M, et al. Pectoralis Major Repair: A Biomechanical Analysis of Modern Repair Configurations Versus Traditional Repair Configuration. Am J Sports Med. 2017;45:2858-2863 pubmed publisher
    ..to modern PM repair techniques that use larger caliber sutures, suture tape, and unicortical button fixation (UBF)...
  80. Rajput P, Shukla S, Kumar V. The HBx oncoprotein of hepatitis B virus potentiates cell transformation by inducing c-Myc-dependent expression of the RNA polymerase I transcription factor UBF. Virol J. 2015;12:62 pubmed publisher
    ..Interestingly, the levels of Upstream Binding Factor (UBF) required for rDNA transcription and ribosome biogenesis are found elevated in the HCC patients...
  81. Jesse S, Bayer H, Alupei M, Zügel M, Mulaw M, Tuorto F, et al. Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington's disease. Sci Rep. 2017;7:8513 pubmed publisher
    ..Upon activation PGC-1α associates with the ribosomal DNA and boosts recruitment of RNA polymerase I and UBF to the rDNA promoter...
  82. Kasyapa C, Kunapuli P, Cowell J. Mass spectroscopy identifies the splicing-associated proteins, PSF, hnRNP H3, hnRNP A2/B1, and TLS/FUS as interacting partners of the ZNF198 protein associated with rearrangement in myeloproliferative disease. Exp Cell Res. 2005;309:78-85 pubmed
    ..In 293 cells expressing the ZNF198/FGFR1 fusion protein, neither PSF nor PTB binds to the fusion protein, possibly because of their differential localization in the cell. ..
  83. Becherel O, Gueven N, Birrell G, Schreiber V, Suraweera A, Jakob B, et al. Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription. Hum Mol Genet. 2006;15:2239-49 pubmed
    ..between aprataxin and several nucleolar proteins, including nucleolin, nucleophosmin and upstream binding factor-1 (UBF-1), involved in ribosomal RNA (rRNA) synthesis and cellular stress signalling...
  84. Xu Y, Wan W, Shou X, Huang R, You Z, Shou Y, et al. TP53INP2/DOR, a mediator of cell autophagy, promotes rDNA transcription via facilitating the assembly of the POLR1/RNA polymerase I preinitiation complex at rDNA promoters. Autophagy. 2016;12:1118-28 pubmed publisher
  85. Jin R, Zhou W. TIF-IA: An oncogenic target of pre-ribosomal RNA synthesis. Biochim Biophys Acta. 2016;1866:189-196 pubmed publisher
    ..TIF-IA is a transcription factor that connects RNA polymerase I with the UBF/SL-1 complex to initiate the transcription of pre-ribosomal RNA...
  86. Vaara S, Hollmen M, Korhonen A, Maksimow M, Ala Kokko T, Salmi M, et al. Soluble CD73 in Critically Ill Septic Patients - Data from the Prospective FINNAKI Study. PLoS ONE. 2016;11:e0164420 pubmed publisher
    ..After multivariable adjustments, sCD73 levels at 0h associated independently neither with the development of AKI nor 90-day mortality...
  87. Chen J, Teo B, Cai Y, Wee S, Lu J. The linker histone H1.2 is a novel component of the nucleolar organizer regions. J Biol Chem. 2018;293:2358-2369 pubmed publisher
    ..Little is known about the composition and structure of NORs, but upstream binding factor (UBF) has been established as its master organizer. In this study, we sought to establish new proteins in NORs...
  88. Hirschler Laszkiewicz I, Cavanaugh A, Mirza A, Lun M, Hu Q, Smink T, et al. Rrn3 becomes inactivated in the process of ribosomal DNA transcription. J Biol Chem. 2003;278:18953-9 pubmed
    ..Our results indicate that Rrn3 functions stoichiometrically in rDNA transcription and that its ability to associate with RNA polymerase I is lost upon transcription. ..
  89. Ke J, Zeng S, Mao J, Wang J, Lou J, Li J, et al. Common genetic variants of GPC1 gene reduce risk of biliary atresia in a Chinese population. J Pediatr Surg. 2016;51:1661-4 pubmed publisher
    ..GPC1 expression via effect on transcription-factor-binding sites (TFBS) of upstream binding transcription factor (UBTF), as a regulatory DNA variation in Deoxyribonuclease I (DNase I) hypersensitive sites (DHSs)...
  90. Xie Q, Li C, Song X, Wu L, Jiang Q, Qiu Z, et al. Folate deficiency facilitates recruitment of upstream binding factor to hot spots of DNA double-strand breaks of rRNA genes and promotes its transcription. Nucleic Acids Res. 2017;45:2472-2489 pubmed publisher
    ..Enrichment H3K4me1 at the hot spots of DSB regions enhanced the recruitment of upstream binding factor (UBF) to rRNA genes, resulting in the increment of rRNA genes transcription...
  91. Rosenfeld C, Cornfield D, Roy T. Ca(2+)-activated K(+) channels modulate basal and E(2)beta-induced rises in uterine blood flow in ovine pregnancy. Am J Physiol Heart Circ Physiol. 2001;281:H422-31 pubmed
    Uterine blood flow (UBF) increases >30-fold during ovine pregnancy. During the last trimester, this reflects vasodilation, which may be due to placentally derived estrogens...
  92. Duhr S, Torres Montaner A, Astola A, García Cozar F, Pendon C, Bolivar J, et al. Molecular analysis of the 5' region of human ribosomal transcription factor UBF. DNA Seq. 2001;12:267-72 pubmed
    ..human genomic clones served to demonstrate that an alternative pre-mRNA splicing of a single gene is used to form UBF1 and UBF2...