Gene Symbol: UBR5
Description: ubiquitin protein ligase E3 component n-recognin 5
Alias: DD5, EDD, EDD1, HYD, E3 ubiquitin-protein ligase UBR5, E3 identified by differential display, E3 ubiquitin-protein ligase, HECT domain-containing 1, HECT-type E3 ubiquitin transferase UBR5, hyperplastic discs protein homolog, progestin-induced protein
Species: human
Products:     UBR5

Top Publications

  1. Eblen S, Kumar N, Shah K, Henderson M, Watts C, Shokat K, et al. Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs. J Biol Chem. 2003;278:14926-35 pubmed
    ..to phosphorylate ERK2-associated proteins in COS-1 cells, we identified the ubiquitin ligase EDD (E3 identified by differential display) and the nucleoporin Tpr (translocated promoter region) as two novel substrates of ERK2, in ..
  2. Sheng Y, Hong J, Doherty R, Srikumar T, Shloush J, Avvakumov G, et al. A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics. 2012;11:329-41 pubmed publisher
    ..Our data set represents the first comprehensive analysis of E2-HECT E3 interactions, and thus provides a framework for better understanding the molecular mechanisms of ubiquitylation. ..
  3. Callaghan M, Russell A, Woollatt E, Sutherland G, Sutherland R, Watts C. Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs. Oncogene. 1998;17:3479-91 pubmed
    ..to isolate progestin-regulated genes in T-47D human breast cancer cells led to identification of a novel gene, EDD. The cDNA sequence contains a 2799 amino acid open reading frame sharing 40% identity with the predicted 2894 amino ..
  4. Henderson M, Russell A, Hird S, Munoz M, Clancy J, Lehrbach G, et al. EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. J Biol Chem. 2002;277:26468-78 pubmed
    The ubiquitin-protein ligase EDD encodes an orthologue of the hyperplastic discs tumor suppressor gene, which has a critical role in Drosophila development...
  5. Henderson M, Munoz M, Saunders D, Clancy J, Russell A, Williams B, et al. EDD mediates DNA damage-induced activation of CHK2. J Biol Chem. 2006;281:39990-40000 pubmed
    b>EDD, the human orthologue of Drosophila melanogaster "hyperplastic discs," is overexpressed or mutated in a number of common human cancers...
  6. O Brien P, Davies M, Scurry J, Smith A, Barton C, Henderson M, et al. The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro. Br J Cancer. 2008;98:1085-93 pubmed publisher
    ..We have previously shown that the E3 ubiquitin ligase, EDD, a regulator of DNA damage responses, is amplified and overexpressed in serous ovarian carcinoma...
  7. Hay Koren A, Caspi M, Zilberberg A, Rosin Arbesfeld R. The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin. Mol Biol Cell. 2011;22:399-411 pubmed publisher
    ..We show that GSK-3? directly interacts with the E3 ubiquitin ligase identified by differential display (EDD) that also binds ?-catenin...
  8. Honda Y, Tojo M, Matsuzaki K, Anan T, Matsumoto M, Ando M, et al. Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response. J Biol Chem. 2002;277:3599-605 pubmed
    ..These results demonstrated that hHYD coordinated TopBP1 in the DNA damage response. ..
  9. Ohshima R, Ohta T, Wu W, Koike A, Iwatani T, Henderson M, et al. Putative tumor suppressor EDD interacts with and up-regulates APC. Genes Cells. 2007;12:1339-45 pubmed
    ..Here we report that APC is up-regulated by EDD, the mammalian orthologue of Drosophila melanogaster"hyperplastic discs" gene (hyd) that is considered to ..

More Information

Publications127 found, 100 shown here

  1. Clancy J, Henderson M, Russell A, Anderson D, Bova R, Campbell I, et al. EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer. Oncogene. 2003;22:5070-81 pubmed
    b>EDD (E3 isolated by differential display), located at chromosome 8q22.3, is the human orthologue of the Drosophila melanogaster tumour suppressor gene 'hyperplastic discs' and encodes a HECT domain E3 ubiquitin protein-ligase...
  2. Munoz M, Saunders D, Henderson M, Clancy J, Russell A, Lehrbach G, et al. The E3 ubiquitin ligase EDD regulates S-phase and G(2)/M DNA damage checkpoints. Cell Cycle. 2007;6:3070-7 pubmed
    ..Mutations or aberrant expression of the E3 ubiquitin ligase EDD have been observed in a number of carcinomas and we recently reported that EDD modulates activity of the DNA damage ..
  3. Sant Anna F, Lebedinsky A, Sokolova T, Robb F, Gonzalez J. Analysis of three genomes within the thermophilic bacterial species Caldanaerobacter subterraneus with a focus on carbon monoxide dehydrogenase evolution and hydrolase diversity. BMC Genomics. 2015;16:757 pubmed publisher
    ..Apart from the CODH-associated hydrogenase, these bacteria also contain other hydrogenases, encoded by ech and hyd genes...
  4. Vizziano Cantonnet D, Lasalle A, Di Landro S, Klopp C, Genthon C. De novo transcriptome analysis to search for sex-differentiation genes in the Siberian sturgeon. Gen Comp Endocrinol. 2018;268:96-109 pubmed publisher
    ..These newly-reported genes are involved in stem-cell niche building and regulation as well as sex-specific nerve development. ..
  5. Zhang S, Loker E, Sullivan J. Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing organ of the snail Biomphalaria glabrata. Dev Comp Immunol. 2016;56:25-36 pubmed publisher
  6. Müller G, Lüchmann K, Razzera G, Toledo Silva G, Bebianno M, Marques M, et al. Proteomic response of gill microsomes of Crassostrea brasiliana exposed to diesel fuel water-accommodated fraction. Aquat Toxicol. 2018;201:109-118 pubmed publisher
    ..The present work can be a basis for future ecotoxicological studies in oysters aiming to elucidate the molecular mechanisms behind diesel-WAF toxicity and for environmental monitoring programs. ..
  7. Kleine Eggebrecht N, Staufner C, Kathemann S, Elgizouli M, Kopajtich R, Prokisch H, et al. Mutation in ITCH Gene Can Cause Syndromic Multisystem Autoimmune Disease With Acute Liver Failure. Pediatrics. 2019;143: pubmed publisher
    ..This case reveals the importance of ubiquitin pathways for regulation of the immune system. ..
  8. Lv Y, Kim K, Sheng Y, Cho J, Qian Z, Zhao Y, et al. YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6. Circ Res. 2018;123:43-56 pubmed publisher
  9. Wu Y, Wu T, Hong C, Wang Y, Yen J. Screening differentially expressed genes in an amphipod (Hyalella azteca) exposed to fungicide vinclozolin by suppression subtractive hybridization. J Environ Sci Health B. 2014;49:856-63 pubmed publisher
    ..Thus, even a non-lethal concentration of vinclozolin still has an effect at the genetic level in H. azteca and presents a potential risk, especially as it would affect non-target organism hormone metabolism. ..
  10. Mohanty A, Farin F, Bammler T, MacDonald J, Afsharinejad Z, Burbacher T, et al. Infant sex-specific placental cadmium and DNA methylation associations. Environ Res. 2015;138:74-81 pubmed publisher
    ..Larger studies are needed to replicate and extend these findings. Such investigations may further our understanding of epigenetic mechanisms underlying maternal Cd burden with suboptimal fetal growth associations. ..
  11. Zhao Y, Cao X, Guo M, Wang X, Yu T, Ye L, et al. Neuralized E3 Ubiquitin Protein Ligase 3 Is an Inducible Antiviral Effector That Inhibits Hepatitis C Virus Assembly by Targeting Viral E1 Glycoprotein. J Virol. 2018;92: pubmed publisher
    ..Our results not only shed new insight into how host innate immunity acts against HCV, but also revealed a new important biological function for NEURL3. ..
  12. Lee A, Rayner S, De Luca A, Gwee S, Morsch M, Sundaramoorthy V, et al. Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex. Open Biol. 2017;7: pubmed publisher
  13. Bai B, Man A, Yang K, Guo Y, Xu C, Tse H, et al. Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. Oncotarget. 2016;7:39065-39081 pubmed publisher
    ..Conclusion-By downregulating acetylated LKB1 protein via HERC2, SIRT1 fine-tunes the crosstalk between endothelial and vascular smooth muscle cells to prevent adverse arterial remodeling and maintain vascular homeostasis. ..
  14. Cheng Q, Wang H, Jiang S, Wang L, Xin L, Liu C, et al. A novel ubiquitin-protein ligase E3 functions as a modulator of immune response against lipopolysaccharide in Pacific oyster, Crassostrea gigas. Dev Comp Immunol. 2016;60:180-90 pubmed publisher
    ..These results demonstrated that CgE3Rv1 was an Ub-protein ligase E3, which was involved in the immune response against LPS and the interaction with cell surface signal molecules of neuroendocrine-immune system in oysters. ..
  15. O Santos A, Parrini M, Camonis J. RalGPS2 Is Essential for Survival and Cell Cycle Progression of Lung Cancer Cells Independently of Its Established Substrates Ral GTPases. PLoS ONE. 2016;11:e0154840 pubmed publisher
    ..This function is largely independent of Ral GTPases and associated with modulation of Skp2, p27 and p21 cell cycle regulators. ..
  16. Liu J, Dong S, Li L, Wang H, Zhao J, Zhao Y. The E3 ubiquitin ligase HECW1 targets thyroid transcription factor 1 (TTF1/NKX2.1) for its degradation in the ubiquitin-proteasome system. Cell Signal. 2019;58:91-98 pubmed publisher
    ..This study will provide a new direction to clarify the molecular regulation of TTF1 in lung and its role in lung epithelial remodeling after injury. ..
  17. Huisamen B, Hafver T, Lumkwana D, Lochner A. The Impact of Chronic Glycogen Synthase Kinase-3 Inhibition on Remodeling of Normal and Pre-Diabetic Rat Hearts. Cardiovasc Drugs Ther. 2016;30:237-46 pubmed publisher
    ..86 ± 2.25 vs 14.92 ± 0.50um(2)) in association with increased end-diastolic diameter (EDD = 8.48 ± 0.11 vs 8.15 ± 0.10 mm). GSK-3 inhibition (i) increased ventricular mass only in controls (1...
  18. Yu P, Eggert K, von Wirén N, Li C, Hochholdinger F. Cell Type-Specific Gene Expression Analyses by RNA Sequencing Reveal Local High Nitrate-Triggered Lateral Root Initiation in Shoot-Borne Roots of Maize by Modulating Auxin-Related Cell Cycle Regulation. Plant Physiol. 2015;169:690-704 pubmed publisher
    ..This study provides unique insights into how adult maize roots translate information on heterogeneous nutrient availability into targeted root developmental responses. ..
  19. Sen A, Acosta Sampson L, Alvaro C, Ahn J, Cate J, Thorner J. Internalization of Heterologous Sugar Transporters by Endogenous α-Arrestins in the Yeast Saccharomyces cerevisiae. Appl Environ Microbiol. 2016;82:7074-7085 pubmed
  20. Liang Z, Lu Y, Qian Y, Zhu L, Kuang S, Chen F, et al. Cultured cells and wing disc size of silkworm can be controlled by the Hippo pathway. Open Biol. 2018;8: pubmed publisher
    ..01); KEGG analysis showed that the up/downregulated genes were enriched in 49/101 pathways. These findings provided novel information to understand the functions of BmYki3 in a cell proliferation and organ-size control pathway. ..
  21. Iimura A, Yamazaki F, Suzuki T, Endo T, Nishida E, Kusakabe M. The E3 ubiquitin ligase Hace1 is required for early embryonic development in Xenopus laevis. BMC Dev Biol. 2016;16:31 pubmed
    ..Our results suggest that Xenopus laevis hace1 plays an important role in early embryonic development, possibly via regulation of Rac1 activity. ..
  22. Yang C, Yuan W, Yang X, Li P, Wang J, Han J, et al. Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression. Mol Cancer. 2018;17:19 pubmed publisher
    ..circ-ITCH acts as a tumor suppressor by a novel circ-ITCH/miR-17, miR-224/p21, PTEN axis, which may provide a potential biomarker and therapeutic target for the management of BCa. ..
  23. Giegerich A, Kuchler L, Sha L, Knape T, Heide H, Wittig I, et al. Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression. Autophagy. 2014;10:1937-52 pubmed publisher
    ..Our observations suggest that autophagy causes PELI3 degradation during TLR4-signaling, thereby impairing the hyperinflammatory phase during sepsis. ..
  24. Leti F, Malenica I, Doshi M, Courtright A, Van Keuren Jensen K, Legendre C, et al. High-throughput sequencing reveals altered expression of hepatic microRNAs in nonalcoholic fatty liver disease-related fibrosis. Transl Res. 2015;166:304-14 pubmed publisher
    ..These findings support a role for hepatic miRNAs in the pathogenesis of NAFLD-related fibrosis and yield possible new insight into the molecular mechanisms underlying the initiation and progression of liver fibrosis and cirrhosis. ..
  25. Sugden S, Pham T, Cohen E. HIV-1 Vpu Downmodulates ICAM-1 Expression, Resulting in Decreased Killing of Infected CD4+ T Cells by NK Cells. J Virol. 2017;91: pubmed publisher
    ..By aiding the immune system to clear infection prior to the development of reservoirs, novel treatments designed to disrupt Vpu-mediated ICAM-1 downregulation may be beneficial during acute infection or as a prophylactic treatment. ..
  26. Shearer R, Iconomou M, Watts C, Saunders D. Functional Roles of the E3 Ubiquitin Ligase UBR5 in Cancer. Mol Cancer Res. 2015;13:1523-32 pubmed publisher
    ..The E3 ligase UBR5 (aka EDD1) is emerging as a key regulator of the UPS in cancer and development...
  27. Grazioli G, Usín D, Trucco E, Sanz M, Montserrat S, Vidal B, et al. Differentiating hypertrophic cardiomyopathy from athlete's heart: An electrocardiographic and echocardiographic approach. J Electrocardiol. 2016;49:539-44 pubmed publisher
    ..in relative septal thickness (RST), calculated as the ratio of 2 x IVS to left ventricle end-diastolic diameter (LV-EDD) (0.37, 0.51, 0.71, respectively; p<0.01) and in spatial QRS-T angle as visually estimated (9.8, 33.6, 66...
  28. Zeng S, Wang Y, Zhang T, Bai L, Wang Y, Duan C. E3 ligase UHRF2 stabilizes the acetyltransferase TIP60 and regulates H3K9ac and H3K14ac via RING finger domain. Protein Cell. 2017;8:202-218 pubmed publisher
    ..In summary, the findings suggest that UHRF2 mediated the post-translational modification of histones and the initiation and progression of cancer. ..
  29. Chicard M, Colmet Daage L, Clement N, Danzon A, Bohec M, Bernard V, et al. Whole-Exome Sequencing of Cell-Free DNA Reveals Temporo-spatial Heterogeneity and Identifies Treatment-Resistant Clones in Neuroblastoma. Clin Cancer Res. 2018;24:939-949 pubmed publisher
    ..Identification of treatment-resistant clones will enable development of more efficient treatment strategies. Clin Cancer Res; 24(4); 939-49. ©2017 AACR. ..
  30. Tan R, Zhang S, Li Y, Tsoi B, Huang W, Yao N, et al. Proanthocyanidins Prevent High Glucose-Induced Eye Malformation by Restoring Pax6 Expression in Chick Embryo. Nutrients. 2015;7:6567-81 pubmed publisher
    ..Chick embryos were exposed to high glucose (0.2 mmol/egg) on embryo development day (EDD) 1. Proanthocyanidins (1 and 10 nmol/egg) were injected into the air sac on EDD 0...
  31. Mansour M, Haupt S, Chan A, Godde N, Rizzitelli A, Loi S, et al. The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling. Cancer Res. 2016;76:4236-48 pubmed publisher
    ..These findings establish E6AP as a novel suppressor of metastasis and provide a compelling rationale for inhibition of ECT2 as a therapeutic approach for patients with metastatic breast cancer. Cancer Res; 76(14); 4236-48. ©2016 AACR. ..
  32. Wang K, Li Y, Hou M. Applicability of genetic polymorphism analysis for the diagnosis of Angelman syndrome and the correlation between language difficulties and disease phenotype. Genet Mol Res. 2016;15: pubmed publisher
    ..Therefore, UBE3A gene mutation analysis combined with comprehensive clinical evaluations may be suitable for the diagnosis of AS. ..
  33. Kanduc D, Shoenfeld Y. From HBV to HPV: Designing vaccines for extensive and intensive vaccination campaigns worldwide. Autoimmun Rev. 2016;15:1054-1061 pubmed publisher
  34. Xu Y, Anderson D, Ye Y. The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation. Cell Discov. 2016;2:16040 pubmed
    ..Altogether, these findings establish a new branch of the cytosolic protein quality control network, which removes surplus polypeptides to control protein homeostasis and nuclear complex assembly. ..
  35. Da Silva L, Fonseca Alves C, Thompson J, Foster R, Wood G, Amorim R, et al. Pilot assessment of vascular endothelial growth factor receptors and trafficking pathways in recurrent and metastatic canine subcutaneous mast cell tumours. Vet Med Sci. 2017;3:146-155 pubmed publisher
    ..There were also significant positive correlations between VEGFR2 and pVEGFR2, and between c-CBL and pVEGFR2 levels. This pilot study demonstrates the potential utility of these markers in a subset of scMCT in dogs...
  36. Seaborne R, Strauss J, Cocks M, Shepherd S, O Brien T, van Someren K, et al. Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy. Sci Rep. 2018;8:1898 pubmed publisher
    ..Further, UBR5, RPL35a, HEG1, PLA2G16, SETD3 displayed hypomethylation and enhanced gene expression following loading, and ..
  37. Jang D, Guo M, Wang D. Proteomic and biochemical studies of calcium- and phosphorylation-dependent calmodulin complexes in Mammalian cells. J Proteome Res. 2007;6:3718-28 pubmed
    ..g., EDD1), calcium-dependent and phosphorylation-independent (e.g...
  38. Dompe N, Rivers C, Li L, Cordes S, Schwickart M, Punnoose E, et al. A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis. Proc Natl Acad Sci U S A. 2011;108:E943-51 pubmed publisher
    ..Interestingly, two of the top hits, EDD1 and GRHL2, are found 50 kb apart on chromosome 8q22, a region that is frequently amplified in many cancers...
  39. Jung H, Wang X, Jun S, Park J. Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation. J Biol Chem. 2013;288:7252-62 pubmed publisher
    ..Phosphorylated TERT is then associated with the EDD-DDB1-VprBP E3 ligase complex for subsequent ubiquitin-mediated TERT protein degradation...
  40. McDonald W, Thomas L, Koirala S, Too C. Progestin-inducible EDD E3 ubiquitin ligase binds to α4 phosphoprotein to regulate ubiquitination and degradation of protein phosphatase PP2Ac. Mol Cell Endocrinol. 2014;382:254-261 pubmed publisher
    ..catalytic subunit (PP2Ac) to regulate PP2A activity, and to poly(A)-binding protein (PABP) and progestin-inducible EDD E3 ubiquitin ligase...
  41. Leng S, Wu G, Collins L, Thomas C, Tellez C, Jauregui A, et al. Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung. Cancer Res. 2015;75:3108-17 pubmed publisher
  42. Yung C, Sha D, Li L, Chin L. Parkin Protects Against Misfolded SOD1 Toxicity by Promoting Its Aggresome Formation and Autophagic Clearance. Mol Neurobiol. 2016;53:6270-6287 pubmed publisher
    ..Our findings reveal parkin-mediated cytoprotective mechanisms against misfolded SOD1 toxicity and suggest that enhancing parkin-mediated cytoprotection may provide a novel therapeutic strategy for treating ALS. ..
  43. Xu D, Wang H, You G. An Essential Role of Nedd4-2 in the Ubiquitination, Expression, and Function of Organic Anion Transporter-3. Mol Pharm. 2016;13:621-30 pubmed publisher
    ..In conclusion, our results provided the first evidence that Nedd4-2 is an important regulator for OAT3 ubiquitination, expression, and transport activity. ..
  44. Chen H, Yang C, Hsieh C, Liu H, Lee S, Tan B. A functional genomic approach reveals the transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1. Biochim Biophys Acta. 2013;1829:1309-19 pubmed publisher
    ..in breast cancer cells, and represents the human ortholog of the Drosophila melanogaster hyperplastic discs gene (hyd)...
  45. Logan Sprenger H, Heigenhauser G, Jones G, Spriet L. The effect of dehydration on muscle metabolism and time trial performance during prolonged cycling in males. Physiol Rep. 2015;3: pubmed publisher
    ..Nine males cycled at ~65% VO2peak for 90 min followed by a TT (6 kJ/kg BM) either with fluid (HYD) or without fluid (DEH)...
  46. Yu Z, Li T, Wang C, Deng S, Zhang B, Huo X, et al. Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells. Oncotarget. 2016;7:15725-37 pubmed publisher
    ..Taken together, our study identified the potential of GBT as a promising therapeutic agent in the treatment of MM. ..
  47. Zhang K, Shardt Y, Chen Z, Peng K. Using the expected detection delay to assess the performance of different multivariate statistical process monitoring methods for multiplicative and drift faults. ISA Trans. 2017;67:56-66 pubmed publisher
    Using the expected detection delay (EDD) index to measure the performance of multivariate statistical process monitoring (MSPM) methods for constant additive faults have been recently developed...
  48. Feng M, Kong X, Zhang J, Xu W, Wu X. Identification of a novel host protein SINAL10 interacting with GP64 and its role in Bombyx mori nucleopolyhedrovirus infection. Virus Res. 2018;247:102-110 pubmed publisher
    ..Collectively, we demonstrated that SINAL10 is a novel GP64-binding protein that stimulates BmNPV proliferation. ..
  49. Gendrot M, Foguim F, Robert M, Amalvict R, Mosnier J, Benoit N, et al. The D113N mutation in the RING E3 ubiquitin protein ligase gene is not associated with ex vivo susceptibility to common anti-malarial drugs in African Plasmodium falciparum isolates. Malar J. 2018;17:108 pubmed publisher
    ..541 and 1). The present data confirmed the absence of the association between polymorphisms in the RING E3 ubiquitin-protein ligase gene and the ex vivo susceptibility to common anti-malarial drugs in African P. falciparum isolates. ..
  50. Dengel D, Jacobs D, Steinberger J, MORAN A, Sinaiko A. Gender differences in vascular function and insulin sensitivity in young adults. Clin Sci (Lond). 2011;120:153-60 pubmed publisher
    ..Insulin sensitivity was determined by euglycaemic insulin clamp. EDD (endothelium-dependent dilation) was determined by flow-mediated dilation using high-resolution ultrasound imaging ..
  51. O Donnell A, Coyle D, Puri P. Decreased expression of NEDL2 in Hirschsprung's disease. J Pediatr Surg. 2016;51:1839-1842 pubmed publisher
    ..We report, for the first time, the expression of NEDL2 in the human colon. The decreased expression of NEDL2 in the aganglionic colon suggests that NEDL2 may play a role in the pathophysiology of HSCR. ..
  52. Bowman L, Balbach J, Walton J, Sargent F, Parkin A. Biosynthesis of Salmonella enterica [NiFe]-hydrogenase-5: probing the roles of system-specific accessory proteins. J Biol Inorg Chem. 2016;21:865-73 pubmed publisher
    ..Salmonella enterica serovar Typhimurium synthesizes the [NiFe]-hydrogenase-5 (Hyd-5) enzyme under aerobic conditions...
  53. Peeters K, Palaima P, Pelayo Negro A, Garcia A, Gallardo E, García Barredo R, et al. Charcot-Marie-Tooth disease type 2G redefined by a novel mutation in LRSAM1. Ann Neurol. 2016;80:823-833 pubmed publisher
    ..Ann Neurol 2016;80:823-833. ..
  54. Jain J, Jain S, Walker L, Tekwani B. Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads. BMC Pharmacol Toxicol. 2017;18:40 pubmed publisher
  55. Shamsipur M, Emami M, Farzin L, Saber R. A sandwich-type electrochemical immunosensor based on in situ silver deposition for determination of serum level of HER2 in breast cancer patients. Biosens Bioelectron. 2018;103:54-61 pubmed publisher
    ..immunosensor, the PB was covered by magnetic gold nanoparticles self-assembled with thiolated antibodies (antiHER2/Hyd@AuNPs-APTMS-Fe3O4) containing chemically reduced silver ions, as a label bioconjugate (LB)...
  56. Xie Z, Liang H, Wang J, Xu X, Zhu Y, Guo A, et al. Significance of the E3 ubiquitin protein UBR5 as an oncogene and a prognostic biomarker in colorectal cancer. Oncotarget. 2017;8:108079-108092 pubmed publisher
    The E3 ubiquitin protein UBR5 has been implicated in the regulation of multiple biological functions and has recently emerged as a key regulator of the ubiquitin-proteasome system (UPS) in cancer...
  57. Wang X, Singh S, Jung H, Yang G, Jun S, Sastry K, et al. HIV-1 Vpr protein inhibits telomerase activity via the EDD-DDB1-VPRBP E3 ligase complex. J Biol Chem. 2013;288:15474-80 pubmed publisher
    ..adaptor, Vpr enhanced the interaction between TERT and the VPRBP substrate receptor of the DYRK2-associated EDD-DDB1-VPRBP E3 ligase complex, resulting in increased ubiquitination of TERT...
  58. Ahmad Panahi H, Ejlali M, Chabouk M. Two-phase and three-phase liquid-phase microextraction of hydrochlorothiazide and triamterene in urine samples. Biomed Chromatogr. 2016;30:1022-1028 pubmed publisher
    ..three-phase hollow fiber based liquid-phase microextraction (HF-LPME) for the extraction of hydrochlorothiazide (HYD) and triamterene (TRM) from human urine...
  59. Tandy S, Meier N, Schulin R. Use of soil amendments to immobilize antimony and lead in moderately contaminated shooting range soils. J Hazard Mater. 2017;324:617-625 pubmed publisher
    ..it had an adverse effect on the leaching of Pb due to its acidifying effect and reductive dissolution of manganese (hyd)roxides...
  60. Cao Y, Jia X, Wei Y, Liu M, Liu J, Li H. Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer's Disease Model Rats Induced by A?1-42. Evid Based Complement Alternat Med. 2016;2016:6840432 pubmed publisher
    i>Objective. Huannao Yicong Decoction (HYD, ) has been shown to improve the learning and memory capabilities of Alzheimer's disease (AD) subjects. However, the underlying mechanism remains to be determined. Methods...
  61. Wang X, Ling L, Huang H, Lin J, Fugmann S, Yang S. Evidence for parallel evolution of a gene involved in the regulation of spermatogenesis. Proc Biol Sci. 2017;284: pubmed publisher
  62. Tian F, Yu C, Ye W, Wang Q. Cinnamaldehyde induces cell apoptosis mediated by a novel circular RNA hsa_circ_0043256 in non-small cell lung cancer. Biochem Biophys Res Commun. 2017;493:1260-1266 pubmed publisher
    ..Above all, we characterized a new mechanism mediated by hsa_circ_0043256/miR-1252/ITCH axis in CA function against NSCLC, providing a novel insight into lung cancer therapy. ..
  63. Green J, Bl M, Simpson J, Dr D, Aa K, Kk N, et al. Effects of 2% Dehydration on Lactate Concentration during Constant-Load Cycling. J Strength Cond Res. 2017;: pubmed publisher
    ..7 ± 5.2 ml•kg•min) male participants (n=9) completed 2 x 40 min constant-load cycling trials; euhydrated (HYD) and following previous evening passive (water bath) dehydration (2% body weight, DEH) (HYD and DEH counterbalanced)..
  64. Knuth M, Temme O, Daldrup T, Pawlik E. Analysis of cocaine adulterants in human brain in cases of drug-related death. Forensic Sci Int. 2018;285:86-92 pubmed publisher
    ..validated for cocaine (COC), benzoylecgonine (BZE), ecgonine methyl ester (EME), diltiazem (DIL), hydroxyzine (HYD), and levamisole (LEV) and partly validated for cetirizine (CET), lidocaine (LID), phenacetin (PHE), and procaine (..
  65. Zheng K, Liu Q, Wang S, Ren Z, Kitazato K, Yang D, et al. HSV-1-encoded microRNA miR-H1 targets Ubr1 to promote accumulation of neurodegeneration-associated protein. Virus Genes. 2018;54:343-350 pubmed publisher
    ..Our results provide novel insights into the mechanism by which HSV-1-encoded miR-H1 functions in neurodegenerative pathogenesis through targeting Ubr1-mediated Arg/N-end rule degradation pathway. ..
  66. Mourik J, van der Tol P, Veldkamp W, Geleijns J. COMPARISON OF WIRELESS DETECTORS FOR DIGITAL RADIOGRAPHY SYSTEMS: IMAGE QUALITY AND DOSE. Radiat Prot Dosimetry. 2016;169:303-7 pubmed publisher
    ..Entrance dose at both the detector (EDD) and phantom (EPD) and image quality were measured for wireless detectors of seven different vendors...
  67. O Connell M, Hayes J. The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic. Biochem Soc Trans. 2015;43:687-9 pubmed publisher
    ..Due to its beneficial role in several diseases, Nrf2 has become a major therapeutic target, with novel natural, synthetic and targeted small molecules currently under investigation to modulate the pathway and in clinical trials. ..
  68. Lesniewski L, Seals D, Walker A, Henson G, Blimline M, Trott D, et al. Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways. Aging Cell. 2017;16:17-26 pubmed publisher
    ..05). Aging was also associated with impaired endothelium-dependent dilation (EDD) in the carotid artery (P < 0.05). Rapamycin improved EDD in old mice (P < 0.05)...
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