UBN1

Summary

Gene Symbol: UBN1
Description: ubinuclein 1
Alias: VT4, HIRA-binding protein, ubinuclein-1, ubiquitously expressed nuclear protein
Species: human

Top Publications

  1. ncbi Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis
    Hideaki Tagami
    Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cell 116:51-61. 2004
  2. pmc Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex
    Yong Tang
    The Wistar Institute, Philadelphia, Pennsylvania 19104, United States
    Biochemistry 51:2366-77. 2012
  3. doi Placing the HIRA histone chaperone complex in the chromatin landscape
    Nikolay A Pchelintsev
    CR UK Beatson Labs, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, UK
    Cell Rep 3:1012-9. 2013
  4. doi Identification of new interacting partners of the shuttling protein ubinuclein (Ubn-1)
    Julien Lupo
    Unit of Virus Host Cell Interactions, UMI 3265 UJF EMBL CNRS, 6 rue Jules Horowitz, BP 181, F 38042 Grenoble Cedex 9, France
    Exp Cell Res 318:509-20. 2012
  5. doi Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity
    Dominique Ray-Gallet
    Centre de Recherche, Institut Curie, 75248 Paris, France
    Mol Cell 44:928-41. 2011
  6. ncbi Characterization of anti-TIMP-1 monoclonal antibodies for immunohistochemical localization in formalin-fixed, paraffin-embedded tissue
    Irene Vejgaard Sorensen
    Institute of Veterinary Pathobiology, The Royal Veterinary and Agricultural University, Ridebanevej 9, 1870 Frederiksberg, Denmark
    J Histochem Cytochem 54:1075-86. 2006
  7. doi Neural distribution of vasotocin receptor mRNA in two species of songbird
    Cary H Leung
    Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
    Endocrinology 152:4865-81. 2011
  8. pmc Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex
    Taranjit Singh Rai
    Institute of Cancer Sciences, CR UK Beatson Labs, University of Glasgow, Switchback Road, Bearsden G61 1BD, United Kingdom
    Mol Cell Biol 31:4107-18. 2011
  9. pmc The nuclear and adherent junction complex component protein ubinuclein negatively regulates the productive cycle of Epstein-Barr virus in epithelial cells
    Henri Gruffat
    U758 INSERM, ENS Lyon, 46 allee d Italie, F 69007 Lyon, France
    J Virol 85:784-94. 2011
  10. pmc Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells
    Gowrishankar Banumathy
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 29:758-70. 2009

Scientific Experts

  • Gianni Bona
  • D L Maney
  • D F Chang
  • Henri Gruffat
  • Peter D Adams
  • Shelley Berger
  • Shelley L Berger
  • Nikolay A Pchelintsev
  • Taranjit Singh Rai
  • Yong Tang
  • Dominique Ray-Gallet
  • Aastha Puri
  • David C Schultz
  • Julien Lupo
  • Ronen Marmorstein
  • Genevieve Almouzni
  • John van Tuyn
  • Tony McBryan
  • Cary H Leung
  • Evelyne Manet
  • Veronique Boyer
  • Patrice Morand
  • Jason Hoffmann
  • Pierre Alain Coly
  • Gowrishankar Banumathy
  • Sirpa Aho
  • Irene Vejgaard Sorensen
  • Gabrielle Barnby
  • Hideaki Tagami
  • Wim P Burmeister
  • Charlotte Sueur
  • Walter Hunziker
  • Raphaëlle Germi
  • Audrey Conti
  • Elise Hoi
  • M Daniel Ricketts
  • Yohann Coute
  • Jason Hoffman
  • Christopher T Goode
  • Céline Pellentz
  • Sarah E Earp
  • Anna V Grozhik
  • Demesew F Abebe
  • Adam Woolfe
  • Prathyusha Mididoddi
  • Isabelle Vassias
  • Nicolas Lacoste
  • Lars E T Jansen
  • S Aho
  • Mark Andrake
  • Hugo Ceulemans
  • Neeta Somaiah
  • David Schultz
  • Amélie Sabine
  • Marc Castellazzi
  • Rugang Zhang
  • Alain Sergeant
  • Henrik Winther
  • Nils Brunner
  • Ulrik Lademann
  • Claus Fenger
  • Niels T Foged
  • Pernille A Usher
  • Andrew Morris
  • Aaron Abbott
  • Anthony P Monaco
  • Anthony J Bailey
  • Nuala Sykes
  • Janine Lamb
  • Daniel E Weeks
  • Richard Mott
  • Yoshihiro Nakatani
  • A Sergeant
  • Y W Ryoo
  • T Pajunen
  • J Uitto
  • J F Giot
  • M Buisson

Detail Information

Publications15

  1. ncbi Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis
    Hideaki Tagami
    Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cell 116:51-61. 2004
    ..This finding provides new insights into possible mechanisms for maintenance of epigenetic information after chromatin duplication...
  2. pmc Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex
    Yong Tang
    The Wistar Institute, Philadelphia, Pennsylvania 19104, United States
    Biochemistry 51:2366-77. 2012
    The mammalian HIRA/UBN1/CABIN1/ASF1a (HUCA) histone chaperone complex deposits the histone H3 variant H3.3 into chromatin and is linked to gene activation, repression, and chromatin assembly in diverse cell contexts...
  3. doi Placing the HIRA histone chaperone complex in the chromatin landscape
    Nikolay A Pchelintsev
    CR UK Beatson Labs, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, UK
    Cell Rep 3:1012-9. 2013
    The HIRA chaperone complex, comprised of HIRA, UBN1, and CABIN1, collaborates with histone-binding protein ASF1a to incorporate histone variant H3.3 into chromatin in a DNA replication-independent manner...
  4. doi Identification of new interacting partners of the shuttling protein ubinuclein (Ubn-1)
    Julien Lupo
    Unit of Virus Host Cell Interactions, UMI 3265 UJF EMBL CNRS, 6 rue Jules Horowitz, BP 181, F 38042 Grenoble Cedex 9, France
    Exp Cell Res 318:509-20. 2012
    ..Altogether, these results suggest that Ubn-1 is a scaffold protein influencing protein subcellular localization and is involved in several processes such as cell-cell contact signalling or modulation of gene activity...
  5. doi Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity
    Dominique Ray-Gallet
    Centre de Recherche, Institut Curie, 75248 Paris, France
    Mol Cell 44:928-41. 2011
    ..3, and HIRA association with Pol II ensures local H3.3 enrichment at specific sites. We discuss the importance of this H3.3 deposition as a salvage pathway to maintain chromatin integrity...
  6. ncbi Characterization of anti-TIMP-1 monoclonal antibodies for immunohistochemical localization in formalin-fixed, paraffin-embedded tissue
    Irene Vejgaard Sorensen
    Institute of Veterinary Pathobiology, The Royal Veterinary and Agricultural University, Ridebanevej 9, 1870 Frederiksberg, Denmark
    J Histochem Cytochem 54:1075-86. 2006
    ..Indirect IHC technique was used, and the seven antibodies (clones VT1, VT2, VT4, VT5, VT6, VT7, and VT8) were tested in various concentrations using different pretreatment protocols...
  7. doi Neural distribution of vasotocin receptor mRNA in two species of songbird
    Cary H Leung
    Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
    Endocrinology 152:4865-81. 2011
    ..we generated partial cDNA sequences for four VT receptor subtypes, VT1, VT2 (V1b), VT3 (oxytocin-like), and VT4 (V1a), in white-throated sparrow (Zonotrichia albicollis) and zebra finch (Taeniopygia guttata)...
  8. pmc Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex
    Taranjit Singh Rai
    Institute of Cancer Sciences, CR UK Beatson Labs, University of Glasgow, Switchback Road, Bearsden G61 1BD, United Kingdom
    Mol Cell Biol 31:4107-18. 2011
    The mammalian HIRA/UBN1/ASF1a complex is a histone chaperone complex that is conserved from yeast (Saccharomyces cerevisiae) to humans. This complex preferentially deposits the histone variant H3...
  9. pmc The nuclear and adherent junction complex component protein ubinuclein negatively regulates the productive cycle of Epstein-Barr virus in epithelial cells
    Henri Gruffat
    U758 INSERM, ENS Lyon, 46 allee d Italie, F 69007 Lyon, France
    J Virol 85:784-94. 2011
    ....
  10. pmc Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells
    Gowrishankar Banumathy
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 29:758-70. 2009
    ..for remote orthologs conserved in multiple species through evolution, we identified the HIRA-associated proteins, UBN1 and UBN2, as candidate human orthologs of Hpc2p...
  11. doi Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos)
    Sirpa Aho
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA
    Biol Cell 101:319-34. 2009
    ..The corresponding mRNA was detected in a wide range of cell types and the protein was highly expressed in the nucleus of human keratinocytes. On the basis of these observations, we named this protein ubinuclein...
  12. pmc Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT
    Gabrielle Barnby
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 76:950-66. 2005
    ..to 16p11-13 were examined for coding variants: A2BP1, ABAT, BFAR, CREBBP, EMP2, GRIN2A, MRTF-B, SSTR5, TBX6, and UBN1. Screening of all coding and regulatory regions by denaturing high-performance liquid chromatography identified ..
  13. ncbi [Secular trend of puberty]
    G Bona
    Clinica Pediatrica, Universita degli Studi del Piemonte Orientale A Avogadro, Novara, Italy
    Minerva Pediatr 54:553-7. 2002
    ..for ages of attainment of B2 and PH2 stages for females and G2, PH2 and testicular volume = or >4 ml (VT4) for males. In females the percentile values for B2 were: 3rd=8.1, 50th=10.5, and 97th=12.6 years...
  14. ncbi SF-36 health survey: tests of data quality, scaling assumptions, and reliability in a community sample of Chinese Americans
    D F Chang
    Department of Psychology, University of California, Los Angeles 90095 1563, USA
    Med Care 38:542-8. 2000
    ....
  15. pmc Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors
    S Aho
    Department of Dermatology, Jefferson Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biol 148:1165-76. 2000
    ..3 and in a syntenic region in mouse chromosome 16. We designated this novel ubiquitously expressed nuclear protein as ubinuclein and the corresponding gene as UBN1.

Research Grants3

  1. A Unique Natural Model for Studying the Mechanisms Underlying Social Behavior
    Donna L Maney; Fiscal Year: 2010
    ..Here, we will study these influences in an animal model with a natural polymorphism that provides a unique opportunity to characterize the processes underlying aggression and parenting. ..