UBN1

Summary

Gene Symbol: UBN1
Description: ubinuclein 1
Alias: VT4, HIRA-binding protein, ubinuclein-1, ubiquitously expressed nuclear protein
Species: human

Top Publications

  1. ncbi Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis
    Hideaki Tagami
    Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cell 116:51-61. 2004
  2. ncbi Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors
    S Aho
    Department of Dermatology, Jefferson Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biol 148:1165-76. 2000
  3. ncbi Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex
    Taranjit Singh Rai
    Institute of Cancer Sciences, CR UK Beatson Labs, University of Glasgow, Switchback Road, Bearsden G61 1BD, United Kingdom
    Mol Cell Biol 31:4107-18. 2011
  4. ncbi The nuclear and adherent junction complex component protein ubinuclein negatively regulates the productive cycle of Epstein-Barr virus in epithelial cells
    Henri Gruffat
    U758 INSERM, ENS Lyon, 46 allee d Italie, F 69007 Lyon, France
    J Virol 85:784-94. 2011
  5. ncbi Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells
    Gowrishankar Banumathy
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 29:758-70. 2009
  6. ncbi Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos)
    Sirpa Aho
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA
    Biol Cell 101:319-34. 2009
  7. ncbi Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT
    Gabrielle Barnby
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 76:950-66. 2005
  8. ncbi [Secular trend of puberty]
    G Bona
    Clinica Pediatrica, Universita degli Studi del Piemonte Orientale A Avogadro, Novara, Italy
    Minerva Pediatr 54:553-7. 2002
  9. ncbi SF-36 health survey: tests of data quality, scaling assumptions, and reliability in a community sample of Chinese Americans
    D F Chang
    Department of Psychology, University of California, Los Angeles 90095 1563, USA
    Med Care 38:542-8. 2000
  10. ncbi Neural distribution of vasotocin receptor mRNA in two species of songbird
    Cary H Leung
    Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
    Endocrinology 152:4865-81. 2011

Research Grants

  1. A Unique Natural Model for Studying the Mechanisms Underlying Social Behavior
    Donna L Maney; Fiscal Year: 2010

Scientific Experts

  • Gianni Bona
  • D L Maney
  • D F Chang
  • Henri Gruffat
  • Shelley L Berger
  • Shelley Berger
  • Cary H Leung
  • Taranjit Singh Rai
  • Yong Tang
  • Peter D Adams
  • Ronen Marmorstein
  • Gowrishankar Banumathy
  • Sirpa Aho
  • Gabrielle Barnby
  • Hideaki Tagami
  • David C Schultz
  • Sarah E Earp
  • Prathyusha Mididoddi
  • Tony McBryan
  • Demesew F Abebe
  • Aastha Puri
  • Christopher T Goode
  • Anna V Grozhik
  • John van Tuyn
  • Jason Hoffman
  • Nikolay A Pchelintsev
  • S Aho
  • Jason Hoffmann
  • Julien Lupo
  • Neeta Somaiah
  • Amélie Sabine
  • Pierre Alain Coly
  • Mark Andrake
  • Patrice Morand
  • David Schultz
  • Marc Castellazzi
  • Rugang Zhang
  • Evelyne Manet
  • Hugo Ceulemans
  • Veronique Boyer
  • Alain Sergeant
  • Andrew Morris
  • Anthony J Bailey
  • Janine Lamb
  • Richard Mott
  • Aaron Abbott
  • Anthony P Monaco
  • Nuala Sykes
  • Daniel E Weeks
  • Dominique Ray-Gallet
  • Genevieve Almouzni
  • Yoshihiro Nakatani
  • T Pajunen
  • J Uitto
  • M Buisson
  • J F Giot
  • A Sergeant
  • Y W Ryoo

Detail Information

Publications10

  1. ncbi Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis
    Hideaki Tagami
    Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cell 116:51-61. 2004
    ..This finding provides new insights into possible mechanisms for maintenance of epigenetic information after chromatin duplication...
  2. ncbi Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors
    S Aho
    Department of Dermatology, Jefferson Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biol 148:1165-76. 2000
    ..3 and in a syntenic region in mouse chromosome 16. We designated this novel ubiquitously expressed nuclear protein as ubinuclein and the corresponding gene as UBN1.
  3. ncbi Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex
    Taranjit Singh Rai
    Institute of Cancer Sciences, CR UK Beatson Labs, University of Glasgow, Switchback Road, Bearsden G61 1BD, United Kingdom
    Mol Cell Biol 31:4107-18. 2011
    The mammalian HIRA/UBN1/ASF1a complex is a histone chaperone complex that is conserved from yeast (Saccharomyces cerevisiae) to humans. This complex preferentially deposits the histone variant H3...
  4. ncbi The nuclear and adherent junction complex component protein ubinuclein negatively regulates the productive cycle of Epstein-Barr virus in epithelial cells
    Henri Gruffat
    U758 INSERM, ENS Lyon, 46 allee d Italie, F 69007 Lyon, France
    J Virol 85:784-94. 2011
    ....
  5. ncbi Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells
    Gowrishankar Banumathy
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 29:758-70. 2009
    ..for remote orthologs conserved in multiple species through evolution, we identified the HIRA-associated proteins, UBN1 and UBN2, as candidate human orthologs of Hpc2p...
  6. ncbi Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos)
    Sirpa Aho
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA
    Biol Cell 101:319-34. 2009
    ..The corresponding mRNA was detected in a wide range of cell types and the protein was highly expressed in the nucleus of human keratinocytes. On the basis of these observations, we named this protein ubinuclein...
  7. ncbi Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT
    Gabrielle Barnby
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 76:950-66. 2005
    ..to 16p11-13 were examined for coding variants: A2BP1, ABAT, BFAR, CREBBP, EMP2, GRIN2A, MRTF-B, SSTR5, TBX6, and UBN1. Screening of all coding and regulatory regions by denaturing high-performance liquid chromatography identified ..
  8. ncbi [Secular trend of puberty]
    G Bona
    Clinica Pediatrica, Universita degli Studi del Piemonte Orientale A Avogadro, Novara, Italy
    Minerva Pediatr 54:553-7. 2002
    ..distribution for ages of attainment of B2 and PH2 stages for females and G2, PH2 and testicular volume = or >4 ml (VT4) for males. In females the percentile values for B2 were: 3rd=8.1, 50th=10.5, and 97th=12.6 years...
  9. ncbi SF-36 health survey: tests of data quality, scaling assumptions, and reliability in a community sample of Chinese Americans
    D F Chang
    Department of Psychology, University of California, Los Angeles 90095 1563, USA
    Med Care 38:542-8. 2000
    ....
  10. ncbi Neural distribution of vasotocin receptor mRNA in two species of songbird
    Cary H Leung
    Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
    Endocrinology 152:4865-81. 2011
    ..we generated partial cDNA sequences for four VT receptor subtypes, VT1, VT2 (V1b), VT3 (oxytocin-like), and VT4 (V1a), in white-throated sparrow (Zonotrichia albicollis) and zebra finch (Taeniopygia guttata)...

Research Grants3

  1. A Unique Natural Model for Studying the Mechanisms Underlying Social Behavior
    Donna L Maney; Fiscal Year: 2010
    ..Here, we will study these influences in an animal model with a natural polymorphism that provides a unique opportunity to characterize the processes underlying aggression and parenting. ..