UBE2V1

Summary

Gene Symbol: UBE2V1
Description: ubiquitin conjugating enzyme E2 V1
Alias: CIR1, CROC-1, CROC1, UBE2V, UEV-1, UEV1, UEV1A, ubiquitin-conjugating enzyme E2 variant 1, DNA-binding protein, TRAF6-regulated IKK activator 1 beta Uev1A
Species: human
Products:     UBE2V1

Top Publications

  1. Sancho E, Vila M, Sanchez Pulido L, Lozano J, Paciucci R, Nadal M, et al. Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. Mol Cell Biol. 1998;18:576-89 pubmed
    ..to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity (HW/GDB-approved gene symbol, UBE2V). At least two human genes code for UEV proteins, and one of them, located on chromosome 20q13...
  2. Xiao W, Lin S, Broomfield S, Chow B, Wei Y. The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. Nucleic Acids Res. 1998;26:3908-14 pubmed
    ..We propose that either these proteins function in a common cellular process, such as DNA repair, or they exert their diverse biological roles through a similar biochemical interaction relative to ubiquitination. ..
  3. Deng L, Wang C, Spencer E, Yang L, Braun A, You J, et al. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell. 2000;103:351-61 pubmed
    ..analysis reveals that this complex is composed of the ubiquitin conjugating enzyme Ubc13 and the Ubc-like protein Uev1A. We find that TRAF6, a RING domain protein, functions together with Ubc13/Uev1A to catalyze the synthesis of ..
  4. McKenna S, Hu J, Moraes T, Xiao W, Ellison M, Spyracopoulos L. Energetics and specificity of interactions within Ub.Uev.Ubc13 human ubiquitin conjugation complexes. Biochemistry. 2003;42:7922-30 pubmed
    ..heterodimer composed of a catalytically active ubiquitin-conjugating enzyme (Ubc13) and its homologue (Mms2 or Uev1a) forms a catalytic scaffold upon which a noncovalently associated acceptor Ub and thiolester-linked donor Ub are ..
  5. Kanayama A, Seth R, Sun L, Ea C, Hong M, Shaito A, et al. TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell. 2004;15:535-48 pubmed
    ..These results indicate that polyubiquitin binding domains represent a new class of signaling domains that regulate protein kinase activity through a nonproteolytic mechanism. ..
  6. Andersen P, Zhou H, Pastushok L, Moraes T, McKenna S, Ziola B, et al. Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A. J Cell Biol. 2005;170:745-55 pubmed
    ..study, we demonstrate that divergent activities of mammalian Ubc13 rely on its pairing with either of two Uevs, Uev1A or Mms2...
  7. Zhang M, Windheim M, Roe S, Peggie M, Cohen P, Prodromou C, et al. Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Mol Cell. 2005;20:525-38 pubmed
    ..Additionally, we identified CHIP as a functional partner of Ubc13-Uev1a in formation of Lys63-linked polyubiquitin chains, extending CHIP's roles into ubiquitin regulation as well as ..
  8. Syed N, Andersen P, Warrington R, Xiao W. Uev1A, a ubiquitin conjugating enzyme variant, inhibits stress-induced apoptosis through NF-kappaB activation. Apoptosis. 2006;11:2147-57 pubmed
    ..b>UEV1A encodes a ubiquitin conjugating enzyme variant, which is required for Ubc13 (ubiquitin conjugating enzyme) ..
  9. Lamothe B, Besse A, Campos A, Webster W, Wu H, Darnay B. Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. J Biol Chem. 2007;282:4102-12 pubmed
    ..Here we show that an intact RING domain of TRAF6 in conjunction with the E2 enzyme Ubc13/Uev1A is necessary for Lys-63-linked auto-ubiquitination of TRAF6 and for its ability to activate IKK and NF-kappaB...

More Information

Publications111 found, 100 shown here

  1. Huen M, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, et al. Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly. Mol Cell Biol. 2008;28:6104-12 pubmed publisher
    ..We propose that the RNF8 RING domain selects and loads a subset of UBC13 molecules, distinct from those that exist as heterodimers, onto sites of double-strand breaks, which facilitates the amplification of DNA damage signals. ..
  2. Yang W, Wang J, Chan C, Lee S, Campos A, Lamothe B, et al. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science. 2009;325:1134-8 pubmed publisher
    ..Thus, Akt ubiquitination is an important step for oncogenic Akt activation. ..
  3. Pertel T, Hausmann S, Morger D, Züger S, Guerra J, Lascano J, et al. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature. 2011;472:361-5 pubmed publisher
    ..Acting with the heterodimeric, ubiquitin-conjugating enzyme UBC13-UEV1A (also known as UBE2N-UBE2V1), TRIM5 catalyses the synthesis of unattached K63-linked ubiquitin chains that activate the TAK1 (also known as ..
  4. Rothofsky M, Lin S. CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter. Gene. 1997;195:141-9 pubmed
    ..Results suggest that CROC-1 participates in intracellular signalling pathways involved in induction of the human FOS promoter. ..
  5. Ma L, Broomfield S, Lavery C, Lin S, Xiao W, Bacchetti S. Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines. Oncogene. 1998;17:1321-6 pubmed
    ..Sequence analysis revealed CIR1 to be identical to the recently cloned CROC1/UEV-1 gene, whereas CIR2 corresponds to an as yet uncharacterized 1.2 kb mRNA...
  6. Hofmann R, Pickart C. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell. 1999;96:645-53 pubmed
    ..These findings support a model in which an Mms2p/Ubc13p complex assembles novel polyubiquitin chains for signaling in DNA repair, and they suggest that UEV proteins may act to increase diversity and selectivity in ubiquitin conjugation. ..
  7. Sun L, Deng L, Ea C, Xia Z, Chen Z. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell. 2004;14:289-301 pubmed
    ..IKK activation in vitro with purified proteins of MALT1, TRAF6, TAK1, and ubiquitination enzymes including Ubc13/Uev1A. We find that a small fraction of BCL10 and MALT1 proteins form high molecular weight oligomers...
  8. Plans V, Scheper J, Soler M, Loukili N, Okano Y, Thomson T. The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation. J Cell Biochem. 2006;97:572-82 pubmed
    ..Thus, our screening reveals new potential regulators of non-canonical polyubiquitylation. ..
  9. Wu C, Conze D, Li T, Srinivasula S, Ashwell J. Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]. Nat Cell Biol. 2006;8:398-406 pubmed
    ..These results provide a mechanism for NEMO's critical role in IKK activation, and a key to understanding the link between cytokine-receptor proximal signalling and IKK and NF-kappaB activation. ..
  10. Petroski M, Zhou X, Dong G, Daniel Issakani S, Payan D, Huang J. Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme. J Biol Chem. 2007;282:29936-45 pubmed
    ..process, we have developed an in vitro system to examine the activity of the ubiquitin-conjugating enzyme UBC13-UEV1A with TRAF6 in which TRAF6 serves as both a ubiquitin ligase and substrate for modification...
  11. Xia Z, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, et al. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature. 2009;461:114-9 pubmed publisher
    ..together with a ubiquitin-conjugating enzyme complex consisting of UBC13 (also known as UBE2N) and UEV1A (UBE2V1) to catalyse Lys 63-linked polyubiquitination, which activates the TAK1 (also known as MAP3K7) kinase complex...
  12. Scheper J, Guerra Rebollo M, Sanclimens G, Moure A, Masip I, González Ruiz D, et al. Protein-protein interaction antagonists as novel inhibitors of non-canonical polyubiquitylation. PLoS ONE. 2010;5:e11403 pubmed publisher
    ..library followed by virtual screening, we have developed small molecules that efficiently antagonize the Ubc13-Uev1 protein-protein interaction, inhibiting the enzymatic activity of the heterodimer...
  13. Liao P, Liao M, Li L, Tan B, Yin Y. Effect of deoxynivalenol on apoptosis, barrier function, and expression levels of genes involved in nutrient transport, mitochondrial biogenesis and function in IPEC-J2 cells. Toxicol Res (Camb). 2017;6:866-877 pubmed publisher
  14. Jiang Y, Li Z, Liu Y, Liu X, Chang Q, Liao Y, et al. Neuroprotective effect of water extract of Panax ginseng on corticosterone-induced apoptosis in PC12 cells and its underlying molecule mechanisms. J Ethnopharmacol. 2015;159:102-12 pubmed publisher
  15. McKee A, Stern R, Nowinski C, Stein T, Alvarez V, Daneshvar D, et al. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2013;136:43-64 pubmed publisher
  16. Senkevich T, Katsafanas G, Weisberg A, Olano L, Moss B. Identification of Vaccinia Virus Replisome and Transcriptome Proteins by Isolation of Proteins on Nascent DNA Coupled with Mass Spectrometry. J Virol. 2017;91: pubmed publisher
    ..The nascent DNA colocalized with the VACV single-stranded DNA binding protein I3 in multiple puncta throughout the interior of factories, which were surrounded by endoplasmic reticulum...
  17. Bari M, Ngo S, Bastie C, Sheppard A, Vatish M. Gestational diabetic transcriptomic profiling of microdissected human trophoblast. J Endocrinol. 2016;229:47-59 pubmed publisher
    ..of these DEGs (8 ubiquitin-conjugating enzymes (UBE) splice variants (UBE2D3 variants 1, 3, 4, 5, 6, 7, and 9) and UBE2V1 variant 4)) were involved in RNA processing and splicing, and a significant number of the DEGs, including the UBE ..
  18. Volonte C, Apolloni S, Parisi C. MicroRNAs: newcomers into the ALS picture. CNS Neurol Disord Drug Targets. 2015;14:194-207 pubmed
    ..C9ORF72), Cu/Zn superoxide dismutase (SOD1), fused in sarcoma/translocated in liposarcoma (FUS/TLS), TAR-DNA binding protein 43 (TDP43)...
  19. Moujalled D, Grubman A, Acevedo K, Yang S, Ke Y, Moujalled D, et al. TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway. Hum Mol Genet. 2017;26:1732-1746 pubmed publisher
    TAR DNA binding protein 43 (TDP-43) is a major disease-associated protein involved in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U)...
  20. Berjón Otero M, Lechuga A, Mehla J, Uetz P, Salas M, Redrejo Rodríguez M. Bam35 tectivirus intraviral interaction map unveils new function and localization of phage ORFan proteins. J Virol. 2017;: pubmed publisher
    ..We also detected interactions involving non-structural proteins, such as the DNA binding protein P1 and the genome terminal protein (P4), which was confirmed by co-immunoprecipitation of recombinant ..
  21. Pearson J, Giogha C, Mühlen S, Nachbur U, Pham C, Zhang Y, et al. EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation. Nat Microbiol. 2017;2:16258 pubmed publisher
  22. Genbacev O, Larocque N, Ona K, Prakobphol A, Garrido Gomez T, Kapidzic M, et al. Integrin ?4-positive human trophoblast progenitors: functional characterization and transcriptional regulation. Hum Reprod. 2016;31:1300-14 pubmed publisher
    ..O., A.P., T.G.-G., M.K., A.B., M.G. have nothing to disclose. S.J.F. received licensing fees and royalties from SeraCare Life Sciences for trisomic TBPC lines that were derived according to the methods described in this manuscript. N/A. ..
  23. Obulhasim G, Yasen M, Kajino K, Mogushi K, Tanaka S, Mizushima H, et al. Up-regulation of dbpA mRNA in hepatocellular carcinoma associated with metabolic syndrome. Hepatol Int. 2013;7:215-25 pubmed publisher
    ..The demethylation-related epigenetic activation may be one of the regulating factors for HCC patients with MS. ..
  24. Yoshihara Hirata C, Yamashiro K, Yamamoto T, Aoyagi H, Ideguchi H, Kawamura M, et al. Anti-HMGB1 Neutralizing Antibody Attenuates Periodontal Inflammation and Bone Resorption in a Murine Periodontitis Model. Infect Immun. 2018;86: pubmed publisher
  25. Lee B, Stallcup M. Glucocorticoid receptor binding to chromatin is selectively controlled by the coregulator Hic-5 and chromatin remodeling enzymes. J Biol Chem. 2017;292:9320-9334 pubmed publisher
    ..Thus, Hic-5 regulates GR binding site selection by a novel mechanism, exploiting gene-specific requirements for chromatin remodeling enzymes to selectively influence DNA occupancy and gene regulation by a transcription factor. ..
  26. Fawcett W, Wolf R. Purification of a MalE-SoxS fusion protein and identification of the control sites of Escherichia coli superoxide-inducible genes. Mol Microbiol. 1994;14:669-79 pubmed
    ..Moreover, MalE-SoxS protected from DNase I attack 22-27 bp segments immediately adjacent to or overlapping the -35 hexamers of the zwf, sodA, nfo, micF, and fumC promoters. The protected regions revealed a consensus 'soxbox' sequence...
  27. Bucelli R, Arhzaouy K, Pestronk A, Pittman S, Rojas L, Sue C, et al. SQSTM1 splice site mutation in distal myopathy with rimmed vacuoles. Neurology. 2015;85:665-74 pubmed publisher
    ..Our data further suggest a pathogenic connection between the disparate phenotypes. ..
  28. Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, et al. TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion. EMBO J. 2016;35:121-42 pubmed publisher
    ..Taken together, our data indicate that impaired mTORC1 signaling and influenced ALP may contribute to TDP-43-mediated neurodegeneration. ..
  29. Takakado A, Nakasone Y, Terazima M. Photoinduced dimerization of a photosensory DNA-binding protein EL222 and its LOV domain. Phys Chem Chem Phys. 2017;19:24855-24865 pubmed publisher
    ..08 compared with that of the EL-LOV domain). This observation suggests that there are inhomogeneous conformations, open and closed types, of EL222 in solution. ..
  30. Wang Y, Jia P, Sharif R, Li Z, Li Y, Chen P. High-Level Production of DNA-Specific Endonuclease AsEndI with Synonymous Codon and its Potential Utilization for Removing DNA Contamination. Appl Biochem Biotechnol. 2018;185:641-654 pubmed publisher
    ..His-AsEndI can remove DNA contamination at high salt conditions, especially for the DNA that may be shielded by DNA-binding protein at low salt conditions. ..
  31. Chand K, Lee K, Lee J, Qiu H, Willis E, Lavidis N, et al. Defects in synaptic transmission at the neuromuscular junction precedes motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis. FASEB J. 2018;: pubmed publisher
    ..Willis, E. F., Lavidis, N. A., Hilliard, M. A., Noakes, P. G. Defects in synaptic transmission at the neuromuscular junction precedes motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis. ..
  32. Phan N, Uebanso T, Shimohata T, Nakahashi M, Mawatari K, Takahashi A. DNA-Binding Protein HU Coordinates Pathogenicity in Vibrio parahaemolyticus. J Bacteriol. 2015;197:2958-64 pubmed publisher
    ..We found that V. parahaemolyticus cytotoxicity is regulated, in a growth rate-independent manner, by the HU proteins through regulation of a number of virulence factors, including T3SS1 gene expression. ..
  33. Cai J, Shen G, Liu S, Meng Q. Downregulation of HMGA2 inhibits cellular proliferation and invasion, improves cellular apoptosis in prostate cancer. Tumour Biol. 2016;37:699-707 pubmed publisher
  34. Correia A, Patel P, Dutta K, Julien J. Inflammation Induces TDP-43 Mislocalization and Aggregation. PLoS ONE. 2015;10:e0140248 pubmed publisher
    ..These results suggest that inflammation may contribute to development or exacerbation of TDP-43 proteinopathies in neurodegenerative disorders. ..
  35. Weiss K, Terhal P, Cohen L, Bruccoleri M, Irving M, Martinez A, et al. De Novo Mutations in CHD4, an ATP-Dependent Chromatin Remodeler Gene, Cause an Intellectual Disability Syndrome with Distinctive Dysmorphisms. Am J Hum Genet. 2016;99:934-941 pubmed publisher
    ..This report provides evidence for the role of CHD4 in human development and expands an increasingly recognized group of Mendelian disorders involving chromatin remodeling and modification. ..
  36. Croft L, Bolderson E, Adams M, El Kamand S, Kariawasam R, Cubeddu L, et al. Human single-stranded DNA binding protein 1 (hSSB1, OBFC2B), a critical component of the DNA damage response. Semin Cell Dev Biol. 2018;: pubmed publisher
    ..While RPA is extremely well characterised, the roles of hSSB1 and hSSB2 have only emerged recently. In this review, we discuss the critical roles that hSSB1 plays in the maintenance of genomic stability. ..
  37. Jamin A, Wicklund A, Wiebe M. Cell- and virus-mediated regulation of the barrier-to-autointegration factor's phosphorylation state controls its DNA binding, dimerization, subcellular localization, and antipoxviral activity. J Virol. 2014;88:5342-55 pubmed publisher
    Barrier-to-autointegration factor (BAF) is a DNA binding protein with multiple cellular functions, including the ability to act as a potent defense against vaccinia virus infection...
  38. Kariawasam R, Touma C, Cubeddu L, Gamsjaeger R. Backbone (1)H, (13)C and (15)N resonance assignments of the OB domain of the single stranded DNA-binding protein hSSB1 (NABP2/OBFC2B) and chemical shift mapping of the DNA-binding interface. Biomol NMR Assign. 2016;10:297-300 pubmed publisher
    ..Our NMR data in combination with further biophysical and biochemical experiments will allow us to address these discrepancies and shed light onto the structural basis of DNA-binding by hSSB1 in solution. ..
  39. Chaurasia N, Mishra Y, Chatterjee A, Rai R, Yadav S, Rai L. Overexpression of phytochelatin synthase (pcs) enhances abiotic stress tolerance by altering the proteome of transformed Anabaena sp. PCC 7120. Protoplasma. 2017;254:1715-1724 pubmed publisher
    ..accumulated proteins belonging to the following categories: (i) detoxification (nutrient stress induced DNA binding protein, Mn-SOD, Alr0946 (CalA)), (ii) protein folding and modification (molecular chaperone DnaK, FKBP-type ..
  40. Lojk J, Prpar Mihevc S, Bregar V, Pavlin M, Rogelj B. The Effect of Different Types of Nanoparticles on FUS and TDP-43 Solubility and Subcellular Localization. Neurotox Res. 2017;32:325-339 pubmed publisher
    ..and TiO2 P25 NPs on intracellular localization and solubility of fused in farcoma (FUS) and TAR-DNA binding protein 43 (TDP-43) that are important pathological hallmarks of amyotrophic lateral sclerosis (ALS) and ..
  41. Naveed M, Tehreem S, Usman M, Chaudhry Z, Abbas G. Structural and functional annotation of hypothetical proteins of human adenovirus: prioritizing the novel drug targets. BMC Res Notes. 2017;10:706 pubmed publisher
    ..We found that these proteins may act as DNA terminal protein, DNA polymerase, DNA binding protein, adenovirus E3 region protein CR1 and adenoviral protein L1...
  42. Machwe A, Lozada E, Wold M, Li G, Orren D. Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage. J Biol Chem. 2011;286:3497-508 pubmed publisher
    ..Taken together, our results suggest that, upon replication blockage, WRN and RPA functionally interact and cooperate to help properly resolve replication forks and maintain genome stability. ..
  43. Yu L, Cheng W, Zhou K, Li W, Yu H, Gao X, et al. Structures of an all-α protein running along the DNA major groove. Nucleic Acids Res. 2016;44:3936-45 pubmed publisher
    ..Together, our findings provide structural insights into the specific interactions between a novel DNA-binding protein and a unique deformed B-DNA. ..
  44. Han A, Kang H, Son J, Kwon D, Kim S, Lee W, et al. The structure of the pleiotropic transcription regulator CodY provides insight into its GTP-sensing mechanism. Nucleic Acids Res. 2016;44:9483-9493 pubmed
    ..Together, data from structural and electrophoretic mobility shift assay analyses improve understanding of how CodY senses GTP and operates as a DNA-binding protein and a pleiotropic transcription regulator. ..
  45. Santana A, Oldenburg D, Kirillov V, Malik L, Dong Q, Sinayev R, et al. RTA Occupancy of the Origin of Lytic Replication during Murine Gammaherpesvirus 68 Reactivation from B Cell Latency. Pathogens. 2017;6: pubmed publisher
    ..ORF6, the gene encoding the single-stranded DNA binding protein, was one of many viral genes that were directly responsive to RTA induction; expression was further ..
  46. Cascella R, Fani G, Capitini C, Rusmini P, Poletti A, Cecchi C, et al. Quantitative assessment of the degradation of aggregated TDP-43 mediated by the ubiquitin proteasome system and macroautophagy. FASEB J. 2017;31:5609-5624 pubmed publisher
    ..Cascella, R., Fani, G., Capitini, C., Rusmini, P., Poletti, A., Cecchi, C., Chiti, F. Quantitative assessment of the degradation of aggregated TDP-43 mediated by the ubiquitin proteasome system and macroautophagy. ..
  47. Schumacher M, den Hengst C, Bush M, Le T, Tran N, Chandra G, et al. The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development. Nat Commun. 2018;9:1139 pubmed publisher
    ..Notably, BldC-like proteins radiate throughout eubacteria, establishing BldC as the founding member of a new structural family of regulators. ..
  48. Tabaka M, Burdzy K, Hołyst R. Method for the analysis of contribution of sliding and hopping to a facilitated diffusion of DNA-binding protein: Application to in vivo data. Phys Rev E Stat Nonlin Soft Matter Phys. 2015;92:022721 pubmed
    ..The short-range hopping to the same base pair interrupts one-dimensional sliding while long-range hopping does not contribute significantly to the kinetics of the search of the target in vivo. ..
  49. Berghuis B, Köber M, van Laar T, Dekker N. High-throughput, high-force probing of DNA-protein interactions with magnetic tweezers. Methods. 2016;105:90-8 pubmed publisher
    ..The approaches detailed here provide guidelines for the high-throughput, quantitative study of a wide range of DNA-protein interactions. ..
  50. Kaneko Y, Daitoku H, Komeno C, Fukamizu A. CTF18 interacts with replication protein A in response to replication stress. Mol Med Rep. 2016;14:367-72 pubmed publisher
    ..These findings provide novel insights into the molecular mechanism underlying the participation of CTF18?RFC in the regulation of replication stress response. ..
  51. Prasad A, Raju G, Sivalingam V, Girdhar A, Verma M, Vats A, et al. An acridine derivative, [4,5-bis{(N-carboxy methyl imidazolium)methyl}acridine] dibromide, shows anti-TDP-43 aggregation effect in ALS disease models. Sci Rep. 2016;6:39490 pubmed publisher
    ..Thus, AIM4 can be a lead molecule potentiating further therapeutic research for ALS. ..
  52. Bianco P, Pottinger S, Tan H, Nguyenduc T, Rex K, Varshney U. The IDL of E. coli SSB links ssDNA and protein binding by mediating protein-protein interactions. Protein Sci. 2017;26:227-241 pubmed publisher
    The E. coli single strand DNA binding protein (SSB) is essential to viability where it functions in two seemingly disparate roles: it binds to single stranded DNA (ssDNA) and to target proteins that comprise the SSB interactome...
  53. Cykowski M, Powell S, Peterson L, Appel J, Rivera A, Takei H, et al. Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis. J Neuropathol Exp Neurol. 2017;76:402-413 pubmed publisher
    To determine the significance of TAR DNA binding protein 43 kDa (TDP-43) pathology in amyotrophic lateral sclerosis (ALS), we examined the whole brains and spinal cords of 57 patients (35 men; 22 women; mean age 63...
  54. Bélanger C, Bérubé Simard F, Leduc E, Bernas G, Campeau P, Lalani S, et al. Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome. Proc Natl Acad Sci U S A. 2018;115:E620-E629 pubmed publisher
    ..We also present evidence that such splicing defects can be corrected in vitro by acute rapamycin treatment. ..
  55. Gan F, Bryant D. Adaptive and acclimative responses of cyanobacteria to far-red light. Environ Microbiol. 2015;17:3450-65 pubmed publisher
    ..A much simpler acclimation response, low-light photoacclimation (LoLiP), occurs in some cyanobacteria that contain the apcD4-apcB3-isiX cluster, which allows cells to grow under low light conditions. ..
  56. Götzl J, Lang C, Haass C, Capell A. Impaired protein degradation in FTLD and related disorders. Ageing Res Rev. 2016;32:122-139 pubmed publisher
  57. Jayaraman P, Devarajan K, Chua T, Zhang H, Gunawan E, Poh C. Blue light-mediated transcriptional activation and repression of gene expression in bacteria. Nucleic Acids Res. 2016;44:6994-7005 pubmed publisher
    ..Overall, our modular approach layers a transformative platform for next-generation light-controllable synthetic biology systems in prokaryotes. ..
  58. Suzuki H, Matsuoka M. The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death. J Biol Chem. 2016;291:21448-21460 pubmed
    ..These findings suggest that the up-regulation of TMEM106B may increase the risk of FTLD by directly causing neurotoxicity and a pathological phenotype linked to FTLD-TDP. ..
  59. Touma C, Adams M, Ashton N, Mizzi M, El Kamand S, Richard D, et al. A data-driven structural model of hSSB1 (NABP2/OBFC2B) self-oligomerization. Nucleic Acids Res. 2017;45:8609-8620 pubmed publisher
    ..While the role of human single-stranded DNA binding protein 1 (hSSB1/NABP2/OBFC2B) in the repair of double-stranded breaks has been well established, we have recently ..
  60. Riku Y, Watanabe H, Yoshida M, Mimuro M, Iwasaki Y, Masuda M, et al. Marked Involvement of the Striatal Efferent System in TAR DNA-Binding Protein 43?kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis. J Neuropathol Exp Neurol. 2016;: pubmed
    ..Thus, striatal efferent projections are essentially and commonly involved in the TDP-43-related FTLD/ALS disease spectrum. ..
  61. Lee A, Seo Y, Choi S, Ryu K, Cheong H, Lee S, et al. NMR elucidation of reduced B-Z transition activity of PKZ protein kinase at high NaCl concentration. Biochem Biophys Res Commun. 2017;482:335-340 pubmed publisher
    A Z-DNA binding protein (ZBP)-containing protein kinase (PKZ) in fish species has an important role in the innate immune response...
  62. Stewart J, Wang Y, Ackerson S, Schuck P. Emerging roles of CST in maintaining genome stability and human disease. Front Biosci (Landmark Ed). 2018;23:1564-1586 pubmed
    The human CTC1-STN1-TEN1 (CST) complex is a single-stranded DNA binding protein that shares homology with RPA and interacts with DNA polymerase alpha/primase...
  63. Machnik G, Bułdak Ł, Ruczyński J, Gąsior T, Huzarska M, Belowski D, et al. The application of strand invasion phenomenon, directed by peptide nucleic acid (PNA) and single-stranded DNA binding protein (SSB) for the recognition of specific sequences of human endogenous retroviral HERV-W family. J Mol Recognit. 2017;30: pubmed publisher
    ..Single-stranded DNA binding protein facilitates the PNA-mediated, sequence-specific formation of strand invasion complex and, consequently, ..
  64. Zhang H, Gan H, Wang Z, Lee J, Zhou H, ORDOG T, et al. RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells. Mol Cell. 2017;65:272-284 pubmed publisher
    ..Through a short hairpin RNA (shRNA) screening, we identified single-stranded DNA binding protein replication protein A (RPA) as a regulator of the deposition of newly synthesized H3.3 into chromatin...
  65. Demin A, Lee M, Lee C, Seo Y. GSK-3? Homolog Rim11 and the Histone Deacetylase Complex Ume6-Sin3-Rpd3 Are Involved in Replication Stress Response Caused by Defects in Dna2. Genetics. 2017;206:829-842 pubmed publisher
    ..Subsequent epistasis analysis revealed that Ume6 (a DNA binding protein, a downstream substrate of Rim11) also acted as a multicopy suppressor of the dna2 allele...
  66. Chen T, Turner B, Beart P, Sheehan Hennessy L, Elekwachi C, Muyderman H. Glutathione monoethyl ester prevents TDP-43 pathology in motor neuronal NSC-34 cells. Neurochem Int. 2018;112:278-287 pubmed publisher
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    Abnormal cytoplasmic mislocalization of transactive response DNA binding protein 43 (TARDBP or TDP-43) in degenerating neurons is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-..