Gene Symbol: UBE2K
Description: ubiquitin conjugating enzyme E2 K
Alias: E2-25K, HIP2, HYPG, LIG, UBC1, ubiquitin-conjugating enzyme E2 K, E2 ubiquitin-conjugating enzyme K, E2(25K), HIP-2, huntingtin-interacting protein 2, ubiquitin carrier protein, ubiquitin conjugating enzyme E2K, ubiquitin-conjugating enzyme E2(25K), ubiquitin-conjugating enzyme E2-25 KDA, ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast), ubiquitin-protein ligase
Species: human
Products:     UBE2K

Top Publications

  1. Saville M, Sparks A, Xirodimas D, Wardrop J, Stevenson L, Bourdon J, et al. Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo. J Biol Chem. 2004;279:42169-81 pubmed
  2. Raasi S, Varadan R, Fushman D, Pickart C. Diverse polyubiquitin interaction properties of ubiquitin-associated domains. Nat Struct Mol Biol. 2005;12:708-14 pubmed
    ..Conversely, non-UBA sequences can modulate the interaction properties of a UBA domain. ..
  3. de Pril R, Fischer D, Roos R, van Leeuwen F. Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases. Mol Cell Neurosci. 2007;34:10-9 pubmed
    ..E2-25K (Hip2), an ubiquitin-conjugating enzyme, interacts directly with huntingtin and may mediate ubiquitination of the ..
  4. Rodrigo Brenni M, Morgan D. Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell. 2007;130:127-39 pubmed
    ..We screened all budding yeast E2s as APC coenzymes in vitro and found that two, Ubc4 and Ubc1, are the key E2 partners for the APC...
  5. Ko S, Kang G, Song S, Lee J, Shin D, Yun J, et al. Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity. J Biol Chem. 2010;285:36070-80 pubmed publisher
    E2-25K/Hip2 is an unusual ubiquitin-conjugating enzyme that interacts with the frameshift mutant of ubiquitin B (UBB(+1)) and has been identified as a crucial factor regulating amyloid-β neurotoxicity...
  6. Zhang S, Loker E, Sullivan J. Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing organ of the snail Biomphalaria glabrata. Dev Comp Immunol. 2016;56:25-36 pubmed publisher
  7. Müller G, Lüchmann K, Razzera G, Toledo Silva G, Bebianno M, Marques M, et al. Proteomic response of gill microsomes of Crassostrea brasiliana exposed to diesel fuel water-accommodated fraction. Aquat Toxicol. 2018;201:109-118 pubmed publisher
    ..The present work can be a basis for future ecotoxicological studies in oysters aiming to elucidate the molecular mechanisms behind diesel-WAF toxicity and for environmental monitoring programs. ..
  8. Kleine Eggebrecht N, Staufner C, Kathemann S, Elgizouli M, Kopajtich R, Prokisch H, et al. Mutation in ITCH Gene Can Cause Syndromic Multisystem Autoimmune Disease With Acute Liver Failure. Pediatrics. 2019;143: pubmed publisher
    ..Mutations in the itchy E3 ubiquitin protein ligase (ITCH) gene (located on chromosome 20q11...
  9. Schmier B, Shuman S. Deinococcus radiodurans HD-Pnk, a Nucleic Acid End-Healing Enzyme, Abets Resistance to Killing by Ionizing Radiation and Mitomycin C. J Bacteriol. 2018;200: pubmed publisher
    ..HD-Pnk is encoded by the LIG-PARG-HD-Pnk three-gene operon, which includes polynucleotide ligase and poly(ADP-ribose) glycohydrolase genes...

More Information

Publications142 found, 100 shown here

  1. Jain J, Jain S, Walker L, Tekwani B. Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads. BMC Pharmacol Toxicol. 2017;18:40 pubmed publisher
  2. Lv Y, Kim K, Sheng Y, Cho J, Qian Z, Zhao Y, et al. YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6. Circ Res. 2018;123:43-56 pubmed publisher
  3. Wu Y, Wu T, Hong C, Wang Y, Yen J. Screening differentially expressed genes in an amphipod (Hyalella azteca) exposed to fungicide vinclozolin by suppression subtractive hybridization. J Environ Sci Health B. 2014;49:856-63 pubmed publisher
    ..Thus, even a non-lethal concentration of vinclozolin still has an effect at the genetic level in H. azteca and presents a potential risk, especially as it would affect non-target organism hormone metabolism. ..
  4. Mohanty A, Farin F, Bammler T, MacDonald J, Afsharinejad Z, Burbacher T, et al. Infant sex-specific placental cadmium and DNA methylation associations. Environ Res. 2015;138:74-81 pubmed publisher
    ..Among females, three sites (near ADP-ribosylation factor-like 9 (ARL9), siah E3 ubiquitin protein ligase family member 3 (SIAH3), and heparin sulfate (glucosamine) 3-O-sulfotransferase 4 (HS3ST4) and one region ..
  5. Lee A, Rayner S, De Luca A, Gwee S, Morsch M, Sundaramoorthy V, et al. Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex. Open Biol. 2017;7: pubmed publisher
  6. Bai B, Man A, Yang K, Guo Y, Xu C, Tse H, et al. Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. Oncotarget. 2016;7:39065-39081 pubmed publisher
    ..that SIRT1, via its amino-terminus, binds to the DOC domain of HERC2 [HECT and RLD domain containing E3 ubiquitin protein ligase 2], which then ubiquitinates LKB1 in the nuclear compartment of endothelial cells...
  7. Tang X, Fu X, Hao B, Zhu F, Xiao S, Xu L, et al. Identification of sumoylated proteins in the silkworm Bombyx mori. Int J Mol Sci. 2014;15:22011-27 pubmed publisher
    ..was constructed to express an enhanced green fluorescent protein (eGFP)-SUMO fusion protein along with ubiquitin carrier protein 9 of Bombyx mori (BmUBC9)...
  8. Tunsagool P, Jutidamrongphan W, Phaonakrop N, Jaresitthikunchai J, Roytrakul S, Leelasuphakul W. Insights into stress responses in mandarins triggered by Bacillus subtilis cyclic lipopeptides and exogenous plant hormones upon Penicillium digitatum infection. Plant Cell Rep. 2019;: pubmed publisher
    ..b>Ubiquitin carrier protein abundance was developed only in the treated flavedo with CLP extract coupled with P. digitatum infection...
  9. O Santos A, Parrini M, Camonis J. RalGPS2 Is Essential for Survival and Cell Cycle Progression of Lung Cancer Cells Independently of Its Established Substrates Ral GTPases. PLoS ONE. 2016;11:e0154840 pubmed publisher
    ..Furthermore, it was associated with the modulation of important cell cycle regulators: the E3 Ubiquitin Protein Ligase S-phase kinase-associated protein 2 (Skp2) was strongly down-regulated (both at mRNA and protein levels), ..
  10. Liu J, Dong S, Li L, Wang H, Zhao J, Zhao Y. The E3 ubiquitin ligase HECW1 targets thyroid transcription factor 1 (TTF1/NKX2.1) for its degradation in the ubiquitin-proteasome system. Cell Signal. 2019;58:91-98 pubmed publisher
    ..Furthermore, we demonstrate that an E3 ubiquitin ligase, named HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (HECW1), targets TTF1 for its ubiquitination and degradation, while downregulation of HECW1 attenuates ..
  11. Yu P, Eggert K, von Wirén N, Li C, Hochholdinger F. Cell Type-Specific Gene Expression Analyses by RNA Sequencing Reveal Local High Nitrate-Triggered Lateral Root Initiation in Shoot-Borne Roots of Maize by Modulating Auxin-Related Cell Cycle Regulation. Plant Physiol. 2015;169:690-704 pubmed publisher
    ..In parallel, a ubiquitin protein ligase S-Phase Kinase-Associated Protein1-cullin-F-box protein(S-Phase Kinase-Associated Protein 2B)-related ..
  12. Sen A, Acosta Sampson L, Alvaro C, Ahn J, Cate J, Thorner J. Internalization of Heterologous Sugar Transporters by Endogenous α-Arrestins in the Yeast Saccharomyces cerevisiae. Appl Environ Microbiol. 2016;82:7074-7085 pubmed
  13. Liang Z, Lu Y, Qian Y, Zhu L, Kuang S, Chen F, et al. Cultured cells and wing disc size of silkworm can be controlled by the Hippo pathway. Open Biol. 2018;8: pubmed publisher
    ..01); KEGG analysis showed that the up/downregulated genes were enriched in 49/101 pathways. These findings provided novel information to understand the functions of BmYki3 in a cell proliferation and organ-size control pathway. ..
  14. Iimura A, Yamazaki F, Suzuki T, Endo T, Nishida E, Kusakabe M. The E3 ubiquitin ligase Hace1 is required for early embryonic development in Xenopus laevis. BMC Dev Biol. 2016;16:31 pubmed
    HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) regulates a wide variety of cellular processes. It has been shown that one of the targets of HACE1 is the GTP-bound form of the small GTPase Rac1...
  15. Yang C, Yuan W, Yang X, Li P, Wang J, Han J, et al. Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression. Mol Cancer. 2018;17:19 pubmed publisher
    Circ-ITCH is a circRNA generated from several exons of itchy E3 ubiquitin protein ligase (ITCH) and tumor suppressor served as a sponge for certain miRNAs targeting their parental transcripts of ITCH...
  16. Giegerich A, Kuchler L, Sha L, Knape T, Heide H, Wittig I, et al. Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression. Autophagy. 2014;10:1937-52 pubmed publisher
    ..Here, we show that PELI3/Pellino3 (pellino E3 ubiquitin protein ligase family member 3), which is an E3 ubiquitin ligase and scaffold protein in TLR4-signaling, is impacted by ..
  17. Sugden S, Pham T, Cohen E. HIV-1 Vpu Downmodulates ICAM-1 Expression, Resulting in Decreased Killing of Infected CD4+ T Cells by NK Cells. J Virol. 2017;91: pubmed publisher
    ..and a dual-serine (S52/S56) motif necessary for recruitment of the beta-transducin repeat-containing E3 ubiquitin protein ligase (β-TrCP) component of the Skp, Cullin, F-box (SCFβ-TrCP) E3 ubiquitin ligase...
  18. Leti F, Malenica I, Doshi M, Courtright A, Van Keuren Jensen K, Legendre C, et al. High-throughput sequencing reveals altered expression of hepatic microRNAs in nonalcoholic fatty liver disease-related fibrosis. Transl Res. 2015;166:304-14 pubmed publisher
    ..We identified forkhead box O3 and F-box WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7) as potential targets of miR-182, and found that levels of forkhead box O3, but not FBXW7, were ..
  19. Wang H, Xu R, Miao J, Si L, Pan L. Comparative transcriptome analysis between the short-term stress and long-term adaptation of the Ruditapes philippinarum in response to benzo[a]pyrene. Aquat Toxicol. 2018;204:59-69 pubmed publisher
  20. Rui L, Weiyi L, Yu M, Hong Z, Jiao Y, Zhe M, et al. The serine/threonine protein kinase of Streptococcus suis serotype 2 affects the ability of the pathogen to penetrate the blood-brain barrier. Cell Microbiol. 2018;20:e12862 pubmed publisher
    ..Differential proteomic analysis showed that E3 ubiquitin protein ligase HECTD1 decreased by 1.5-fold in Δstk-infected bEnd.3 cells relative to ZY05719-infected cells...
  21. Stiasny A, Kuhn C, Mayr D, Alexiou C, Janko C, Wiest I, et al. Immunohistochemical Evaluation of E6/E7 HPV Oncoproteins Staining in Cervical Cancer. Anticancer Res. 2016;36:3195-8 pubmed
    ..E6 protein of HPV types 16 and 18 interacts with the E3 ubiquitin protein ligase, resulting in ubiquitination and proteolysis of tumor protein p53...
  22. Chen G, Zhao X, Tan Z, Wang D, Luo D, Zhang P, et al. Investigation of the role of cullin 4A overexpression in human liver cancer. Mol Med Rep. 2018;18:2531-2540 pubmed publisher
  23. Marrocco K, Criqui M, Zervudacki J, Schott G, Eisler H, Parnet A, et al. APC/C-mediated degradation of dsRNA-binding protein 4 (DRB4) involved in RNA silencing. PLoS ONE. 2012;7:e35173 pubmed publisher
    ..In particular, the APC/C (Anaphase Promoting Complex or Cyclosome) is a master ubiquitin protein ligase (E3) that targets regulatory proteins for degradation allowing sister chromatid separation and exit from ..
  24. O Connell M, Hayes J. The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic. Biochem Soc Trans. 2015;43:687-9 pubmed publisher
    ..Due to its beneficial role in several diseases, Nrf2 has become a major therapeutic target, with novel natural, synthetic and targeted small molecules currently under investigation to modulate the pathway and in clinical trials. ..
  25. Freitas S, Martins R, Campos A, Azevedo J, Osorio H, Costa M, et al. Insights into the potential of picoplanktonic marine cyanobacteria strains for cancer therapies - Cytotoxic mechanisms against the RKO colon cancer cell line. Toxicon. 2016;119:140-51 pubmed publisher
    ..05), and altered proteins (13, p < 0.05) belonged to apoptosis (PSMA5, PSMA7, TPT1, UBE2K), cell cycle (EIF4E, PCNA), cellular metabolism (AHSG, GLO1, ATP5H, HSP90AB1, NME1, HNRNPC) and cell structure (..
  26. Dhamad A, Zhou Z, Zhou J, Du Y. Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ER?) and Biochemical Characterization of the ER?-Hsp70 Interaction. PLoS ONE. 2016;11:e0160312 pubmed publisher
    ..Further studies showed that significant portions of Hsp70-1 and Hsc70 were associated with transcriptionally active chromatin and inactive chromatin, and the two Hsps interacted with ER? in both forms of the chromatins in MCF7 cells. ..
  27. Tolkach Y, Merseburger A, Herrmann T, Kuczyk M, Serth J, Imkamp F. Signatures of Adverse Pathological Features, Androgen Insensitivity and Metastatic Potential in Prostate Cancer. Anticancer Res. 2015;35:5443-51 pubmed
    ..marker of proliferation Ki-67 (MKI67), mucin 1, cell surface associated (MUC1), MYC binding protein 2, E3 ubiquitin protein ligase (MYCBP2), somatostatin receptor 1 (SSTR1), topoisomerase (DNA) II alpha 170 kDa (TOP2A) and exportin 6 (..
  28. Wang K, Li Y, Hou M. Applicability of genetic polymorphism analysis for the diagnosis of Angelman syndrome and the correlation between language difficulties and disease phenotype. Genet Mol Res. 2016;15: pubmed publisher
    ..syndrome (AS) is a neurogenetic disorder caused by a defect in the expression of the maternally inherited ubiquitin protein ligase E3A (UBE3A) gene in chromosome 15...
  29. Park M, Raftery M, Thomas P, Geczy C, Bryant K, Tedla N. Leukocyte immunoglobulin-like receptor B4 regulates key signalling molecules involved in FcγRI-mediated clathrin-dependent endocytosis and phagocytosis. Sci Rep. 2016;6:35085 pubmed publisher
    ..candidate proteins in these pathways included common γ-chain of the Fc receptors, Syk, clathrin, E3 ubiquitin protein ligase Cbl, hepatocyte growth factor-regulated tyrosine kinase substrate, tripartite motif-containing 21 and ..
  30. Anzovino A, Chiang S, Brown B, Hawkins C, Richardson D, Huang M. Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3? Axis. Am J Pathol. 2017;187:2858-2875 pubmed publisher
    ..This process involved the following: i) increased Gsk3? activation, ii) ?-transducin repeat containing E3 ubiquitin protein ligase nuclear accumulation, and iii) Fyn phosphorylation...
  31. Gaweda Walerych K, Mohagheghi F, Zekanowski C, Buratti E. Parkinson's disease-related gene variants influence pre-mRNA splicing processes. Neurobiol Aging. 2016;47:127-138 pubmed publisher
    ..repeat containing protein]; TFAM, [mitochondrial transcription factor A]; PARK2, [parkin RBR E3 ubiquitin protein ligase]; and HSPA9, [heat shock protein family A (Hsp70) member 9]), 4 LRPPRC variants, (IVS32-3C>T, IVS35+..
  32. Nyati K, Masuda K, Zaman M, Dubey P, Millrine D, Chalise J, et al. TLR4-induced NF-?B and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a. Nucleic Acids Res. 2017;45:2687-2703 pubmed publisher
    ..late phase of LPS stimulation, p38 MAPK phosphorylates Arid5a and recruits the WW domain containing E3 ubiquitin protein ligase 1 (WWP1) to its complex, which in turn ubiquitinates Arid5a in a K48-linked manner, leading to its ..
  33. Dong X, Xu M, Ren Z, Gu J, Lu M, Lu Q, et al. Regulation of CBL and ESR1 expression by microRNA-22?3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthma. Int J Mol Med. 2016;38:446-56 pubmed publisher
    ..01), whereas the transcript levels of Cbl proto-oncogene, E3 ubiquitin protein ligase (CBL), peroxisome proliferator?activated receptor gamma, coactivator 1 beta (PPARGC1B), and estrogen ..
  34. Lee C, Hong S, Lee M, Koo H. A PHF8 homolog in C. elegans promotes DNA repair via homologous recombination. PLoS ONE. 2015;10:e0123865 pubmed publisher
    ..1 worms to ICLs was rescued by knockdown of lig-4, a homolog of Ligase 4 active in nonhomologous end-joining. The hypersensitivity of jmjd-1...
  35. Tang B, Liu X, Shi Z, Shen Q, Xu Y, Wang S, et al. Transcriptome analysis and identification of induced genes in the response of Harmonia axyridis to cold hardiness. Comp Biochem Physiol Part D Genomics Proteomics. 2017;22:78-89 pubmed publisher
    ..Information on these cold-resistance response genes will improve the development of low-temperature storage technology of natural enemy insects for future use in biological control. ..
  36. Sun C, Li L, Li X, Zhang W, Liu X. Novel SNPs of WNK1 and AKR1C3 are associated with preeclampsia. Gene. 2018;: pubmed publisher
    ..283-2.157, respectively). The findings indicate that the GG genotype of AKR1C3 rs10508293 is associated with decreased risk for preeclampsia and the AA genotype of WNK1 rs1468326 are related with an increased risk for preeclampsia. ..
  37. Wang X, Yang J, Han L, Zhao K, Wu Q, Bao L, et al. TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression. J Biol Chem. 2015;290:29086-94 pubmed publisher
    ..In this study, we show that tumor necrosis factor receptor-associated factor 5 (TRAF5), known as an E3 ubiquitin protein ligase and signal transducer, interacts with and ubiquitinates RORγt via Lys-63-linked polyubiquitination...
  38. Prosser D, Pannunzio A, Brodsky J, Thorner J, Wendland B, O Donnell A. α-Arrestins participate in cargo selection for both clathrin-independent and clathrin-mediated endocytosis. J Cell Sci. 2015;128:4220-34 pubmed publisher
    ..contribute to recognition of specific cargos and promote their ubiquitylation by recruiting the E3 ubiquitin protein ligase Rsp5...
  39. Kinsella E, Dorà N, Mellis D, Lettice L, Deveney P, Hill R, et al. Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development. PLoS ONE. 2016;11:e0157079 pubmed publisher
    ..Elaboration of the cellular/molecular mechanism(s) involved may help our understanding on diseases and developmental disorders associated with aberrant Hh signalling. ..
  40. Cote Orozco J, Mera Solarte P, Espinosa García E. [Neuropsychiatric phenotype of Angelman syndrome and clinical care: report of seven cases]. Arch Argent Pediatr. 2017;115:e99-e103 pubmed publisher
    ..caused by a lack or reduction of expression of UBE3A located within chromosome 15, which codes for ubiquitin protein ligase E3A, which has a key role in synaptic development and neural plasticity...
  41. Ha T, Moon K, Dai L, Hatakeyama J, Yoon K, Park H, et al. The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina. Cell Rep. 2017;19:351-363 pubmed publisher
    ..Notch ligand activity in various neighbors of retinal progenitor cells (RPCs) by eliminating mindbomb E3 ubiquitin protein ligase 1 (Mib1)...
  42. Vara A, Fernández González M, Aira M, Rodríguez Rajo F. Oleaceae cross-reactions as potential pollinosis cause in urban areas. Sci Total Environ. 2016;542:435-40 pubmed publisher
    ..The Fra e 1 and Lig v 1 allergens were detected by means Ole e 1 antibodies...
  43. Wang Z, Chen S, Nie Z, Zhang J, Zhou Z, Deng T, et al. Climatic Factors Drive Population Divergence and Demography: Insights Based on the Phylogeography of a Riparian Plant Species Endemic to the Hengduan Mountains and Adjacent Regions. PLoS ONE. 2015;10:e0145014 pubmed publisher
    ..nuclear gene (glyceraldehyde 3-phosphate dehydrogenase; G3pdh), and climatic data during the Last Interglacial (LIG; c. 120-140 ka), Last Glacial Maximum (LGM; c. 21 ka), and Current (c. 1950-2000) periods were used in this study...
  44. Castiblanco Valencia M, Fraga T, Pagotto A, Serrano S, Abreu P, Barbosa A, et al. Plasmin cleaves fibrinogen and the human complement proteins C3b and C5 in the presence of Leptospira interrogans proteins: A new role of LigA and LigB in invasion and complement immune evasion. Immunobiology. 2016;221:679-89 pubmed publisher
    ..Leptospira interrogans binds plasminogen, which is converted to active plasmin. Leptospiral immunoglobulin-like (Lig) proteins are surface exposed molecules that interact with extracellular matrix components and complement ..
  45. Kim H, Kunz P, Mooney R, Philpot B, Smith S. Maternal Loss of Ube3a Impairs Experience-Driven Dendritic Spine Maintenance in the Developing Visual Cortex. J Neurosci. 2016;36:4888-94 pubmed publisher
    ..Angelman syndrome (AS), which is caused by the loss of the maternally inherited UBE3A allele (encoding ubiquitin protein ligase E3A)...
  46. Lim J, Shin H, Chung K, Kim N, Kim J, Jung H, et al. E2-EPF UCP Possesses E3 Ubiquitin Ligase Activity via Its Cysteine 118 Residue. PLoS ONE. 2016;11:e0163710 pubmed publisher
    Here, we show that E2-EPF ubiquitin carrier protein (UCP) elongated E3-independent polyubiquitin chains on the lysine residues of von Hippel-Lindau protein (pVHL) and its own lysine residues both in vitro and in vivo...
  47. Zhang J, Gambin T, Yuan B, Szafranski P, Rosenfeld J, Balwi M, et al. Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features. Hum Genet. 2017;136:377-386 pubmed publisher
    ..Finally, our data enable expansion of the phenotypic spectrum of ubiquitin-proteasome dependent disorders. ..
  48. Tian F, Yu C, Ye W, Wang Q. Cinnamaldehyde induces cell apoptosis mediated by a novel circular RNA hsa_circ_0043256 in non-small cell lung cancer. Biochem Biophys Res Commun. 2017;493:1260-1266 pubmed publisher
    ..which could in turn directly target a vital negative regulator of Canonical Wnt signaling, Itchy E3 ubiquitin protein ligase (ITCH), as validated by dual-luciferase assay...
  49. Feng M, Kong X, Zhang J, Xu W, Wu X. Identification of a novel host protein SINAL10 interacting with GP64 and its role in Bombyx mori nucleopolyhedrovirus infection. Virus Res. 2018;247:102-110 pubmed publisher
    ..Collectively, we demonstrated that SINAL10 is a novel GP64-binding protein that stimulates BmNPV proliferation. ..
  50. Sato S, Ishikawa H, Yoshikawa H, Izumikawa K, Simpson R, Takahashi N. Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5'-3' exoribonuclease) in the nucleoplasm. Nucleic Acids Res. 2015;43:10397-410 pubmed publisher
    ..These observations suggest that CARF regulates early steps of pre-rRNA processing during ribosome biogenesis by controlling spatial distribution of XRN2 between the nucleoplasm and nucleolus. ..
  51. Jawhar A, Hermanns S, Ponelies N, Obertacke U, Roehl H. Tourniquet-induced ischaemia during total knee arthroplasty results in higher proteolytic activities within vastus medialis cells: a randomized clinical trial. Knee Surg Sports Traumatol Arthrosc. 2016;24:3313-3321 pubmed
    ..Additional high-quality research may be warranted to examine the short- and long-term clinical significance of the present data. I. ..
  52. de Bock C, Hughes M, Snyder K, Alley S, Sadeqzadeh E, Dun M, et al. Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels. FEBS Lett. 2017;591:667-678 pubmed publisher
    ..We conclude that SH3RF1 acts as a negative post-translational regulator of FAT1 levels. ..
  53. Kumazoe M, Nakamura Y, Yamashita M, Suzuki T, Takamatsu K, Huang Y, et al. Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216. J Biol Chem. 2017;292:4077-4088 pubmed publisher
    ..Furthermore, this agonist intake prevented HF/HS-induced hyperinsulinemia and hypertriglyceridemia. Taken together, 67LR presents an attractive target for the relief of obesity-induced inflammation. ..
  54. Serra S, Chetty R. Rnf43. J Clin Pathol. 2017;: pubmed publisher
    ..Mutations of RNF43 have been reported in different cancers. We describe the structure of RNF43, its function and most frequent mutations in different cancers...
  55. Xu J, Xing S, Cui H, Chen X, Wang X. Genome-wide identification and characterization of the apple (Malus domestica) HECT ubiquitin-protein ligase family and expression analysis of their responsiveness to abiotic stresses. Mol Genet Genomics. 2016;291:635-46 pubmed publisher
    ..The results of this study helped to elucidate the functions of HECT proteins, especially in Rosaceae plants. ..
  56. Cheng Q, Wang H, Jiang S, Wang L, Xin L, Liu C, et al. A novel ubiquitin-protein ligase E3 functions as a modulator of immune response against lipopolysaccharide in Pacific oyster, Crassostrea gigas. Dev Comp Immunol. 2016;60:180-90 pubmed publisher
    ..These results demonstrated that CgE3Rv1 was an Ub-protein ligase E3, which was involved in the immune response against LPS and the interaction with cell surface signal molecules of neuroendocrine-immune system in oysters. ..
  57. Salker M, Steel J, Hosseinzadeh Z, Nautiyal J, Webster Z, Singh Y, et al. Activation of SGK1 in Endometrial Epithelial Cells in Response to PI3K/AKT Inhibition Impairs Embryo Implantation. Cell Physiol Biochem. 2016;39:2077-2087 pubmed
    ..Taken together, our data indicate that the balanced activities of two related serine/threonine kinases, AKT and SGK1, critically govern the implantation process. ..
  58. Liu J, Li X, Zhang H, Gu R, Wang Z, Gao Z, et al. Ubiquitin E3 ligase Itch negatively regulates osteoblast function by promoting proteasome degradation of osteogenic proteins. Bone Joint Res. 2017;6:154-161 pubmed publisher
    ..The expression levels of WW Domain Containing E3 Ubiquitin Protein Ligase 1 (Wwp1), SMAD Specific E3 Ubiquitin Protein Ligase 1 (Smurf1), SMAD Specific E3 Ubiquitin Protein Ligase ..
  59. Liu M, Huang K, Qian L, Chatterjee P, Zhang S, Li R, et al. Effects of bioactive constituents in the Traditional Chinese Medicinal formula Si-Wu-Tang on Nrf2 signaling and neoplastic cellular transformation. Phytomedicine. 2018;40:1-9 pubmed publisher
    ..Three of the nine compounds predicted as Nrf2 activators by molecular docking, gallic acid (GA), Z-liguistilide (LIG), and senkyunolide A (SA), were confirmed with highest potency of increasing the Nrf2/ARE promoter activity and ..
  60. Faivre L, Parietti V, Siñeriz F, Chantepie S, Gilbert Sirieix M, Albanese P, et al. In vitro and in vivo evaluation of cord blood hematopoietic stem and progenitor cells amplified with glycosaminoglycan mimetic. Stem Cell Res Ther. 2016;7:3 pubmed publisher
    ..UCB CD34+ cells were expanded with serum-free medium, SCF, TPO, FLT3-lig and G-CSF during 12 days in the absence or the presence of increasing OTR4131 concentrations (0-100 μg/mL)...
  61. Peters M, Guidato P, Peters K, Megger D, Sitek B, Classen B, et al. Allergy-Protective Arabinogalactan Modulates Human Dendritic Cells via C-Type Lectins and Inhibition of NF-κB. J Immunol. 2016;196:1626-35 pubmed publisher
    ..We conclude that AG dampens the activation of human DCs by LPS via binding to DC-SIGN and MMR-1, leading to attenuated TLR signaling. This results in a reduced T cell activation capacity of DCs. ..
  62. Ying M, Zhang L, Zhou Q, Shao X, Cao J, Zhang N, et al. The E3 ubiquitin protein ligase MDM2 dictates all-trans retinoic acid-induced osteoblastic differentiation of osteosarcoma cells by modulating the degradation of RARα. Oncogene. 2016;35:4358-67 pubmed publisher
    ..Therefore, our study indicates that MDM2 serves as an E3 ubiquitin ligase to regulate the degradation of RARα and suggests that MDM2 is a novel therapeutic target for ATRA-based differentiation therapeutic approaches in osteosarcoma. ..
  63. Gautier C, Erpapazoglou Z, Mouton Liger F, Muriel M, Cormier F, Bigou S, et al. The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations. Hum Mol Genet. 2016;25:2972-2984 pubmed
    Mutations in PARK2, encoding the E3 ubiquitin protein ligase Parkin, are a common cause of autosomal recessive Parkinson's disease (PD)...
  64. Liang J, Wang W, Xie S, Zhang X, Qi W, Zhou X, et al. ?-transducin repeat-containing E3 ubiquitin protein ligase inhibits migration, invasion and proliferation of glioma cells. Oncol Lett. 2017;14:3131-3135 pubmed publisher
    transducin repeat-containing E3 ubiquitin protein ligase (?-TrCP) serves as the substrate recognition subunit for the Skp1-Cullin1-F-box protein E3 ubiquitin ligase, which recognizes the double phosphorylated DSG (X)2+nS ..
  65. David Y, Ternette N, Edelmann M, Ziv T, Gayer B, Sertchook R, et al. E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes. J Biol Chem. 2011;286:44104-15 pubmed publisher
    ..Based on several model systems, we propose that although interaction with an E2 is sufficient to promote substrate ubiquitination the E3 molds the reaction into a specific, physiologically relevant protein modification. ..
  66. Giardino Torchia M, Munitic I, Castro E, Herz J, McGavern D, Ashwell J. c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival. Eur J Immunol. 2015;45:2672-82 pubmed publisher
    ..Studies with T-cell adoptive transfer demonstrated that the enhanced decay of memory cells was T-cell intrinsic. Thus, c-IAP E3 activity is required for 4-1BB coreceptor signaling and maintenance of CD8(+) T-cell memory. ..
  67. Ma Y, Yan M, Huang H, Zhang L, Wang Q, Zhao Y, et al. Associations and prognostic significance of p27Kip1, Jab1 and Skp2 in non-Hodgkin lymphoma. Mol Clin Oncol. 2016;5:357-364 pubmed
    ..kinase-interacting protein-2 (Skp2), the substrate recognition subunit of the Skp1-Cul1-F-box protein ubiquitin protein ligase complex, is required for the ubiquitination and consequent degradation of p27...
  68. Kim S, Kim H, Park M, Huh J, Park H, Ha S, et al. Mitochondrial E3 Ubiquitin Protein Ligase 1 Mediates Cigarette Smoke-Induced Endothelial Cell Death and Dysfunction. Am J Respir Cell Mol Biol. 2016;54:284-96 pubmed publisher
    ..Here, we assessed the involvement of mitochondrial E3 ubiquitin protein ligase 1 (MUL1), recently revealed as a novel Akt ubiquitin E3 ligase, in cigarette smoke-induced Akt ..
  69. Gao L, Emond M, Louie T, Cheadle C, Berger A, Rafaels N, et al. Identification of Rare Variants in ATP8B4 as a Risk Factor for Systemic Sclerosis by Whole-Exome Sequencing. Arthritis Rheumatol. 2016;68:191-200 pubmed publisher
    ..Differential ATP8B4 expression was observed among the SSc patients compared to the controls (P = 0.0005). ATP8B4 may represent a putative genetic risk factor for SSc and pulmonary vascular complications. ..
  70. Breda L, Hsieh C, Castiblanco Valencia M, da Silva L, Barbosa A, Blom A, et al. Fine Mapping of the Interaction between C4b-Binding Protein and Outer Membrane Proteins LigA and LigB of Pathogenic Leptospira interrogans. PLoS Negl Trop Dis. 2015;9:e0004192 pubmed publisher
    ..Therefore, C4BP and heparin may share the same binding sites on Lig proteins.
  71. Bai L, Shi W, Liu J, Zhao X, Zhang Y, Zhou Z, et al. Protective effect of pilose antler peptide on cerebral ischemia/reperfusion (I/R) injury through Nrf-2/OH-1/NF-κB pathway. Int J Biol Macromol. 2017;102:741-748 pubmed publisher
    ..b>Lig also could effectively decrease the levels of interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis ..
  72. Helms K, Wilson R, Ogungbe I, Setzer W, Twigg P. Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K. Nat Prod Commun. 2011;6:1411-6 pubmed
    ..An IC50 for vitexin was calculated to be approximately 0.5 mM. Molecular modeling simulations were used to predict the mode of inhibition and NMR spectra were used to confirm the binding site of vitexin to E2-25K. ..
  73. Goto Y, Kojima S, Kurozumi A, Kato M, Okato A, Matsushita R, et al. Regulation of E3 ubiquitin ligase-1 (WWP1) by microRNA-452 inhibits cancer cell migration and invasion in prostate cancer. Br J Cancer. 2016;114:1135-44 pubmed publisher
    ..WW domain-containing E3 ubiquitin protein ligase-1 (WWP1) was a direct target of miR-452, and knockdown of WWP1 inhibited the migration and invasion of ..
  74. Kalva S, Agrawal N, Skelton A, Saleena L. Identification of novel selective MMP-9 inhibitors as potential anti-metastatic lead using structure-based hierarchical virtual screening and molecular dynamics simulation. Mol Biosyst. 2016;12:2519-31 pubmed publisher
    ..Among 33 tested, 2 molecules, P10A-0000088030 (Lig-1) and P10A-0001383812 (Lig-2), were found to have the highest docking scores (-8.59 kcal mol(-1) and -8...
  75. Jeong E, Chung H, Lee W, Kim S, Kim H, Choi S, et al. E2-25K SUMOylation inhibits proteasome for cell death during cerebral ischemia/reperfusion. Cell Death Dis. 2016;7:e2573 pubmed publisher
    ..This proteasome inhibitory activity of E2-25K is dependent on its SUMOylation. These results suggest that E2-25K has a crucial role in oxidative stress and cerebral I/R-induced damage through inhibiting proteasome via its SUMOylation. ..
  76. Bauer R, Jurkiw T, Evans T, Lohman G. Rapid Time Scale Analysis of T4 DNA Ligase-DNA Binding. Biochemistry. 2017;56:1117-1129 pubmed publisher
    ..all cases, confirming prior proposals of transient binding followed by a transition to a productive ligase·nDNA (Lig·nDNA) conformation but suggesting that weaker nonproductive "closed" complexes are formed as well...
  77. Papadopoulos T, Casemayou A, Neau E, Breuil B, Caubet C, Calise D, et al. Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction. BMC Syst Biol. 2017;11:31 pubmed publisher
    ..Our data revealed let-7a and miR-29b as molecules potentially involved in the development of fibrosis in UPJ obstruction via the control of DTX4 in both man and mice that would not be identified otherwise. ..
  78. Beaver J, Lai Y, Rolle S, Liu Y. Proliferating cell nuclear antigen prevents trinucleotide repeat expansions by promoting repeat deletion and hairpin removal. DNA Repair (Amst). 2016;48:17-29 pubmed publisher
    ..through the coordination among the key BER enzymes DNA polymerase ?, flap endonuclease 1 (FEN1) and DNA ligase I (LIG I). However, it remains unknown whether BER cofactors can also alter TNR stability...
  79. Zhao Y, Wang H, Chen W, Zhao P, Gong H, Sang X, et al. Regional association analysis-based fine mapping of three clustered QTL for verticillium wilt resistance in cotton (G. hirsutum. L). BMC Genomics. 2017;18:661 pubmed publisher
    ..The tandem arrangement of R genes were detected in the redefined confidence interval of QTL-JESPR0001. The candidate genes obtained should be helpful in identifying and characterizing defense genes related to VW resistance QTL. ..
  80. Bai Y, Zhang Y, Han B, Yang L, Chen X, Huang R, et al. Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity. J Neurosci. 2018;38:32-50 pubmed publisher
    ..to inhibit miR-143 activity, resulting in the inhibition of homologous to the E6-AP C-terminal domain E3 ubiquitin protein ligase 1 expression...
  81. Christensen D, Brzovic P, Klevit R. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. Nat Struct Mol Biol. 2007;14:941-8 pubmed
    ..interactions between the human heterodimeric RING E3 BRCA1-BARD1 and the human E2s UbcH6, Ube2e2, UbcM2, Ubc13, Ube2k and Ube2w...
  82. Tang L, Yi X, Chen J, Chen F, Lou W, Gao Y, et al. Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells. Oncotarget. 2016;7:15738-46 pubmed publisher
    ..Inhibiting UBE3C activity may suppress melanoma invasion and metastasis and may represent a targeted therapeutic approach. ..
  83. Kawada K, Mimori S. Implication of Endoplasmic Reticulum Stress in Autism Spectrum Disorder. Neurochem Res. 2018;43:147-152 pubmed publisher
    ..Because other ubiquitin ligases are related with neurite outgrowth, ER stress may be related to the pathogenesis of neuronal developmental diseases via abnormalities of neuronal differentiation or maturation. ..
  84. Henshall T, Manning J, Alfassy O, Goel P, Boase N, Kawabe H, et al. Deletion of Nedd4-2 results in progressive kidney disease in mice. Cell Death Differ. 2017;24:2150-2160 pubmed publisher
    NEDD4-2 (NEDD4L), a ubiquitin protein ligase of the Nedd4 family, is a key regulator of cell surface expression and activity of the amiloride-sensitive epithelial Na+ channel (ENaC)...
  85. Long F, Shi M, Zhou H, Liu D, Sang N, Du J. Klotho upregulation contributes to the neuroprotection of ligustilide against cerebral ischemic injury in mice. Eur J Pharmacol. 2018;820:198-205 pubmed publisher
    ..Furthermore, klotho upregulation contributes to the neuroprotection of LIG against cerebral ischemic injury...
  86. Bassermann F, Frescas D, Guardavaccaro D, Busino L, Peschiaroli A, Pagano M. The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell. 2008;134:256-67 pubmed publisher
    ..These findings define a novel pathway that is crucial for the G2 DNA-damage-response checkpoint. ..
  87. Singh R, Zerath S, Kleifeld O, Scheffner M, Glickman M, Fushman D. Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system. Mol Cell Proteomics. 2012;11:1595-611 pubmed publisher
    ..Taken together, these findings suggest that once Rub1/Nedd8 is channeled into ubiquitin pathways, it is recognized essentially like ubiquitin. ..
  88. Rajsbaum R, Versteeg G, Schmid S, Maestre A, Belicha Villanueva A, Martínez Romero C, et al. Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKK? kinase-mediated antiviral response. Immunity. 2014;40:880-95 pubmed publisher
    ..TRIM6 and the E2-ubiquitin conjugase UbE2K cooperated in the synthesis of unanchored K48-linked polyubiquitin chains, which activated IKK? for subsequent ..
  89. Zhang Q, Fan L, Hou F, Dong A, Wang Y, Tong Y. New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins. Sci Rep. 2015;5:15660 pubmed publisher
    ..We also demonstrated that RNA duplex binding to RC3H2 cross-talks with its E3 ubiquitin ligase function using an in vitro auto-ubiquitination assay. ..
  90. Onenc S, Retschitzegger S, Evic N, Kienzl N, Yanik J. Characteristics and synergistic effects of co-combustion of carbonaceous wastes with coal. Waste Manag. 2018;71:192-199 pubmed publisher
    ..fuels: poultry litter (PL) and its char (PLC), scrap tires (ST) and its char (STC) and blends of char/lignite (PLC/LIG and STC/LIG)...
  91. Salami M, Kaveian F, Rafienia M, Saber Samandari S, Khandan A, Naeimi M. Electrospun Polycaprolactone/lignin-based Nanocomposite as a Novel Tissue Scaffold for Biomedical Applications. J Med Signals Sens. 2017;7:228-238 pubmed
    ..There are various attempts for incorporation of biopolymers with cheap natural micro- or nanoparticles like lignin (Lig), alginate, and gums to prepare new materials with enhanced properties.
  92. Goswami J, Sahu J, Singhi P. Angelman Syndrome Due to UBE3A Gene Mutation. Indian J Pediatr. 2018;85:390-391 pubmed publisher
    ..Exome sequencing revealed a previously unreported mutation of Ubiquitin Protein Ligase E3A (UBE3A) gene, confirming the diagnosis of Angelman syndrome...