Gene Symbol: U2AF1L4
Description: U2 small nuclear RNA auxiliary factor 1 like 4
Alias: U2AF1-RS3, U2AF1L3, U2AF1L3V1, U2AF1RS3, U2af26, splicing factor U2AF 26 kDa subunit, U2 auxiliary factor 26, U2 small nuclear RNA auxiliary factor 1-like 3, U2 small nuclear RNA auxiliary factor 1-like protein 3, U2 small nuclear RNA auxiliary factor 1-like protein 4, U2(RNU2) small nuclear RNA auxiliary factor 1-like 3, U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3, U2AF1-like 4, U2AF1-like protein 3
Species: human
Products:     U2AF1L4

Top Publications

  1. Sokhonevich N, Yurova K, Gutsol A, Khaziakhmatova O, Mazunin I, Litvinova L. Effects of Immunoregulatory Cytokines (IL-2, IL-7, and IL-15) on Expression of Gfi1 and U2afll4 Genes in T Cells at Different Stages of Differentiation. Bull Exp Biol Med. 2015;159:236-9 pubmed publisher
    Opposite effects of common γ-chain cytokines (IL-2, IL-7, and IL-15) on the expression of Gfi1 and U2af1l4 genes regulating alternative splicing of Ptprc gene in T cells at different stages of differentiation were demonstrated in ..
  2. Heyd F, Carmo Fonseca M, Moroy T. Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26. J Biol Chem. 2008;283:19636-45 pubmed publisher
    ..expression, intracellular localization, and nucleo-cytoplasmic shuttling of one homolog of the small U2AF subunit, U2AF26, and a splice variant lacking exon 7, U2AF26DeltaE7...
  3. Pearsall R, Shibata H, Brozowska A, Yoshino K, Okuda K, deJong P, et al. Absence of imprinting in U2AFBPL, a human homologue of the imprinted mouse gene U2afbp-rs. Biochem Biophys Res Commun. 1996;222:171-7 pubmed
    ..RT-PCR analysis of human placentas using the KpnI polymorphism to determine the parental origin of the alleles indicates biallelic expression of the human chromosome 5 U2AFBPL gene. ..
  4. Shepard J, Reick M, Olson S, Graveley B. Characterization of U2AF(6), a splicing factor related to U2AF(35). Mol Cell Biol. 2002;22:221-30 pubmed
    ..Based on its sequence and functional similarity to U2AF(35), U2AF(26) may play a role in regulating alternative splicing. ..
  5. Yurova K, Sokhonevich N, Khaziakhmatova O, Litvinova L. [Cytokine-mediated regulation of expression of Gfi1 and U2afll4 genes activated by T-cells with different differentiation status in vitro]. Biomed Khim. 2016;62:180-6 pubmed publisher
    ..CD45RO+ T-cells exposed to an antigen-independent activation; they caused a dose-dependent decrease of the U2af1l4 gene expression, and an increase of Gfi1 gene expression...
  6. Zamorina S, Litvinova L, Yurova K, Khaziakhmatova O, Timganova V, Bochkova M, et al. The role of human chorionic gonadotropin in regulation of naïve and memory T cells activity in vitro. Int Immunopharmacol. 2018;54:33-38 pubmed publisher
    ..In parallel, expression of U2af1l4, Gfi1, and hnRNPLL genes, which are Ptprc gene alternative splicing regulators was evaluated...
  7. Kitagawa K, Wang X, Hatada I, Yamaoka T, Nojima H, Inazawa J, et al. Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1. Genomics. 1995;30:257-63 pubmed
    ..Amino acid sequences of human U2AF1-RS1 and U2AF-RS2 showed significant homology to U2AF small subunit. The group 3 gene, designated as U2AF1-RS3, of which the cDNA has not yet been isolated, was mapped to chromosome 19p13.2. ..
  8. Dou T, Ji C, Gu S, Chen F, Xu J, Ye X, et al. Cloning and characterization of a novel splice variant of human Rab18 gene (RAB18). DNA Seq. 2005;16:230-4 pubmed
    ..RT-PCR shows that the cDNA has different expression pattern with RAB18 and is highly expressed in testis. ..
  9. Didych D, Smirnov N, Kotova E, Akopov S, Nikolaev L, Sverdlov E. Functional dissection of an enhancer-like element located within the second intron of the human U2AF1L4 gene. Biochemistry (Mosc). 2011;76:951-7 pubmed publisher
    ..analysis of an enhancer element of the human genome (enhancer 12) located in the second intron of the U2AF1L4 gene, which we identified earlier, is presented...

More Information


  1. Didych D, Shamsutdinov M, Smirnov N, Akopov S, Monastyrskaya G, Uspenskaya N, et al. Human PSENEN and U2AF1L4 genes are concertedly regulated by a genuine bidirectional promoter. Gene. 2013;515:34-41 pubmed publisher
    ..present experimental evidence that, according to several criteria, a 269 bp region located between the PSENEN and U2AF1L4 human genes is a genuine bidirectional promoter regulating a concerted divergent transcription of these genes...