Gene Symbol: TZF
Description: zinc finger protein 318
Alias: HRIHFB2436, TZF, ZFP318, zinc finger protein 318, endocrine regulator, endocrine regulatory protein, testicular zinc finger
Species: human
Products:     TZF

Top Publications

  1. Mäkelä J, Saario V, Bourguiba Hachemi S, Nurmio M, Jahnukainen K, Parvinen M, et al. Hedgehog signalling promotes germ cell survival in the rat testis. Reproduction. 2011;142:711-21 pubmed publisher
    ..The key endocrine regulator of germ cell differentiation, FSH, down-regulates Dhh mRNA levels in vitro...
  2. Ramos Alonso L, Romero A, Soler M, Perea García A, Alepuz P, Puig S, et al. Yeast Cth2 protein represses the translation of ARE-containing mRNAs in response to iron deficiency. PLoS Genet. 2018;14:e1007476 pubmed publisher
    ..The tandem zinc finger (TZF)-containing protein Cth2 plays a critical role in this adaptation by binding and promoting the degradation of ..
  3. Hinoi E. [Pivotal role of skeletal tissues in the regulation mechanisms for physiological functions mediated by multiple organ networks]. Yakugaku Zasshi. 2012;132:721-5 pubmed
    ..We then revealed that the skeleton acts as an endocrine regulator of energy metabolism through the osteoblast-specific secreted molecule osteocalcin that activates insulin ..
  4. Kim W, Kim J, Ko J, Kang H, Kim J, Han K. AtC3H14, a plant-specific tandem CCCH zinc-finger protein, binds to its target mRNAs in a sequence-specific manner and affects cell elongation in Arabidopsis thaliana. Plant J. 2014;80:772-84 pubmed publisher
    AtC3H14 (At1 g66810) is a plant-specific tandem CCCH zinc-finger (TZF) protein that belongs to the 68-member CCCH family in Arabidopsis thaliana...
  5. Huesa C, Zhu D, Glover J, Ferron M, Karsenty G, Milne E, et al. Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes. Dis Model Mech. 2014;7:1341-50 pubmed publisher
    The emergence of bone as an endocrine regulator has prompted a re-evaluation of the role of bone mineralization factors in the development of metabolic disease...
  6. Chen C, Susanto H, Chuang W, Liu T, Wang C. Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function. Cardiovasc Diabetol. 2016;15:3 pubmed publisher
    ..65, 95 % confidence interval (CI) 2.17-14.57, P < 0.001]. Betatrophin is significantly increased in T2DM patients with different stages of albuminuria. Betatrophin may be a novel endocrine regulator involved in DN development.
  7. Daryadel A, Bettoni C, Haider T, Imenez Silva P, Schnitzbauer U, Pastor Arroyo E, et al. Erythropoietin stimulates fibroblast growth factor 23 (FGF23) in mice and men. Pflugers Arch. 2018;470:1569-1582 pubmed publisher
    Fibroblast growth factor 23 (FGF23) is a major endocrine regulator of phosphate and 1,25 (OH)2 vitamin D3 metabolism and is mainly produced by osteocytes...
  8. Chai G, Kong Y, Zhu M, Yu L, Qi G, Tang X, et al. Arabidopsis C3H14 and C3H15 have overlapping roles in the regulation of secondary wall thickening and anther development. J Exp Bot. 2015;66:2595-609 pubmed publisher
    Plant tandem CCCH zinc finger (TZF) proteins play diverse roles in developmental and adaptive processes. Arabidopsis C3H14 has been shown to act as a potential regulator of secondary wall biosynthesis...
  9. Stefanaki C, Pervanidou P, Boschiero D, Chrousos G. Chronic stress and body composition disorders: implications for health and disease. Hormones (Athens). 2018;17:33-43 pubmed publisher
    ..Third, the bone is also a systemic endocrine regulator playing a pivotal role in health and disease...

More Information


  1. Wang W, Ma L, Liu M, Zhao T, Zhang T, Yang Y, et al. A novel function for fibroblast growth factor 21: stimulation of NADPH oxidase-dependent ROS generation. Endocrine. 2015;49:385-95 pubmed publisher
    Fibroblast growth factor 21 (FGF-21) is a major paracrine and endocrine regulator of metabolic homeostasis. Here we demonstrate that FGF-21 is also a potent mediator of innate immunity...
  2. Norman V, Hughes W. Behavioural effects of juvenile hormone and their influence on division of labour in leaf-cutting ant societies. J Exp Biol. 2016;219:8-11 pubmed publisher
    ..JH mediation of behaviour occurs across multiple independent evolutions of eusociality, and may be a key endocrine regulator of the division of labour which has produced the remarkable ecological and evolutionary success of social ..
  3. Abdallah B, Ditzel N, Laborda J, Karsenty G, Kassem M. DLK1 Regulates Whole-Body Glucose Metabolism: A Negative Feedback Regulation of the Osteocalcin-Insulin Loop. Diabetes. 2015;64:3069-80 pubmed publisher
    ..Recently, we identified delta like-1 (DLK1) as an endocrine regulator of bone turnover...
  4. Zofkova I. Bone tissue as a systemic endocrine regulator. Physiol Res. 2015;64:439-45 pubmed
    ..Finally, osteocalcin stimulates testosterone synthesis in Leydig cells and thus may play some role in male fertility. Further studies are necessary to confirm clinically important roles for skeletal tissue in systemic regulations. ..
  5. Heidegger H, Jeschke U. Human Chorionic Gonadotropin (hCG)-An Endocrine, Regulator of Gestation and Cancer. Int J Mol Sci. 2018;19: pubmed publisher
    ..Human Chorionic Gonadotropin (hCG) is a heterodimeric glycoprotein composed of two subunits [...]. ..
  6. Bonnet N. Bone-Derived Factors: A New Gateway to Regulate Glycemia. Calcif Tissue Int. 2017;100:174-183 pubmed publisher
    ..The emergence of bone as an endocrine regulator through FGF23 and osteocalcin has led to the re-evaluation of the role of bone cells and bone-derived ..
  7. Moreno Fernandez J, Diaz Castro J, Pulido Moran M, Alférez M, Nestares T, López Aliaga I. Fermented goat milk consumption during anaemia recovery: ergogenic effect and improvement of skeletal muscle homeostasis. Eur J Nutr. 2017;56:2277-2287 pubmed publisher
    ..during anaemia recovery diminishes adiposity depots and enhances lipolysis, increasing UCP1, PepT1 and irisin protein expression, featuring an ergogenic effect in the SM which is an important endocrine regulator of body metabolism.
  8. Hu P, Huang B, Xia X, Xuan Q, Hu B, Qin Y. Therapeutic effect of CNP on renal osteodystrophy by antagonizing the FGF-23/MAPK pathway. J Recept Signal Transduct Res. 2016;36:213-9 pubmed publisher
    ..In addition, fibroblast growth factor (FGF)-23 is a bone-derived endocrine regulator of phosphate homeostasis...
  9. Turner M, Cronin J, Noleto P, Sheldon I. Glucose Availability and AMP-Activated Protein Kinase Link Energy Metabolism and Innate Immunity in the Bovine Endometrium. PLoS ONE. 2016;11:e0151416 pubmed publisher
    ..inflammatory responses to lipopolysaccharide were not affected by insulin-like growth factor-1, which is an endocrine regulator of metabolism...
  10. Pamminger T, TREANOR D, Hughes W. Pleiotropic effects of juvenile hormone in ant queens and the escape from the reproduction-immunocompetence trade-off. Proc Biol Sci. 2016;283: pubmed publisher
    ..Lasius niger have escaped the reproduction-immunocompetence trade-off by decoupling the effects of a key endocrine regulator of fertility and immunocompetence in solitary insects, juvenile hormone (JH)...
  11. Galardo M, Gorga A, Merlo J, Regueira M, Pellizzari E, Cigorraga S, et al. Participation of HIFs in the regulation of Sertoli cell lactate production. Biochimie. 2017;132:9-18 pubmed publisher
    ..Considering that FSH is the master endocrine regulator of Sertoli cells, it is not surprising that this hormone may employ several regulatory mechanisms to ..
  12. Jang J. Arginine-rich motif-tandem CCCH zinc finger proteins in plant stress responses and post-transcriptional regulation of gene expression. Plant Sci. 2016;252:118-124 pubmed publisher
    Tandem CCCH zinc finger (TZF) proteins are evolutionarily conserved regulators of gene expression at the post-transcriptional level...
  13. Suk F, Chang C, Lin R, Lin S, Liu S, Jau C, et al. ZFP36L1 and ZFP36L2 inhibit cell proliferation in a cyclin D-dependent and p53-independent manner. Sci Rep. 2018;8:2742 pubmed publisher
    ..include ZFP36, ZFP36L1, and ZFP36L2, which belong to CCCH-type zinc finger proteins with two tandem zinc finger (TZF) regions. Whether ZFP36L1 and ZFP36L2 have antiproliferative activities similar to that of ZFP36 is unclear...
  14. Wells M, Hicks S, Perera L, Blackshear P. Functional equivalence of an evolutionarily conserved RNA binding module. J Biol Chem. 2015;290:24413-23 pubmed publisher
    ..Related proteins from most groups of eukaryotes contain a conserved tandem zinc finger (TZF) domain consisting of two closely spaced, similar CCCH zinc fingers that form the primary RNA binding domain...
  15. Koller L, Kleber M, Brandenburg V, Goliasch G, Richter B, Sulzgruber P, et al. Fibroblast Growth Factor 23 Is an Independent and Specific Predictor of Mortality in Patients With Heart Failure and Reduced Ejection Fraction. Circ Heart Fail. 2015;8:1059-67 pubmed publisher
    ..Fibroblast growth factor 23 (FGF-23) is an endocrine regulator of phosphate and vitamin D homeostasis associated with an increased cardiovascular risk...
  16. Bogamuwa S, Jang J. Plant Tandem CCCH Zinc Finger Proteins Interact with ABA, Drought, and Stress Response Regulators in Processing-Bodies and Stress Granules. PLoS ONE. 2016;11:e0151574 pubmed publisher confirm that AtTZF5 can interact with MARD1 and RD21A in plant cells, and the interaction is mediated through TZF motif. In addition, AtTZF4 and 6 could also interact with MARD1 and RD21A in Y-2-H and BiFC assay, respectively...
  17. Ishizuka M, Ohtsuka E, Inoue A, Odaka M, Ohshima H, Tamura N, et al. Abnormal spermatogenesis and male infertility in testicular zinc finger protein Zfp318-knockout mice. Dev Growth Differ. 2016;58:600-8 pubmed publisher
    b>Zfp318, a mouse gene with a Cys2/His2 zinc finger motif, is mainly expressed in germ cells in the testis...
  18. Trebotic L, Klimek P, Thomas A, Fenzl A, Leitner K, Springer S, et al. Circulating Betatrophin Is Strongly Increased in Pregnancy and Gestational Diabetes Mellitus. PLoS ONE. 2015;10:e0136701 pubmed publisher
    ..In the light of the previously reported role in lipid metabolism, betatrophin may represent a novel endocrine regulator of lipid alterations in pregnancy...
  19. Seok H, Nguyen L, Park H, Tarte V, Ha J, Lee S, et al. Arabidopsis non-TZF gene AtC3H17 functions as a positive regulator in salt stress response. Biochem Biophys Res Commun. 2018;498:954-959 pubmed publisher
    ..of CCCH-type zinc finger proteins in abiotic stress responses have largely focused on tandem CCCH-type zinc finger (TZF) genes, whereas the study of functional roles of non-TZF genes in abiotic stress responses has largely been ..
  20. Morgan B, Deveau L, Massi F. Probing the structural and dynamical effects of the charged residues of the TZF domain of TIS11d. Biophys J. 2015;108:1503-1515 pubmed publisher
    ..We posit that favorable electrostatic interactions provide a mechanism to promote preferential orientation of separate domains without imposing structural rigidity. ..
  21. Xie T, Leung P. Fibroblast growth factor 21: a regulator of metabolic disease and health span. Am J Physiol Endocrinol Metab. 2017;313:E292-E302 pubmed publisher
    Fibroblast growth factor 21 (FGF21) is a potent endocrine regulator with physiological effects on glucose and lipid metabolism and thus garners much attention for its translational potential for the management of obesity and related ..
  22. Bellaïche J, Goupil A, Sambroni E, Lareyre J, Le Gac F. Gdnf-Gfra1 pathway is expressed in a spermatogenetic-dependent manner and is regulated by Fsh in a fish testis. Biol Reprod. 2014;91:94 pubmed publisher
    ..Fsh is an endocrine regulator of SSCs self-renewal through the up-regulation of Gdnf in rodents...
  23. Tao R, Kawate H, Ohnaka K, Ishizuka M, Hagiwara H, Takayanagi R. Opposite effects of alternative TZF spliced variants on androgen receptor. Biochem Biophys Res Commun. 2006;341:515-21 pubmed
    We previously demonstrated that testicular zinc-finger protein (TZF) was a corepressor of the androgen receptor (AR)...
  24. Feng T, Schutz L, Morrell B, Perego M, Spicer L. Effect of melatonin on bovine theca cells in vitro. Reprod Fertil Dev. 2017;: pubmed publisher
    ..In conclusion, melatonin may act as an endocrine regulator of ovarian function in cattle by stimulating theca cell proliferation and inhibiting differentiation via ..
  25. Sánchez N, Quinn K, Ashley A, Ashley R. In the ovine pituitary, CXCR4 is localized in gonadotropes and somatotropes and increases with elevated serum progesterone. Domest Anim Endocrinol. 2018;62:88-97 pubmed publisher
    The pituitary is the central endocrine regulator of reproduction and in addition to various hormones regulating its actions, other molecules, such as chemokines, influence pituitary physiology as well...
  26. Frieten D, Gerbert C, Koch C, Dusel G, Eder K, Hoeflich A, et al. Influence of ad libitum milk replacer feeding and butyrate supplementation on the systemic and hepatic insulin-like growth factor I and its binding proteins in Holstein calves. J Dairy Sci. 2018;101:1661-1672 pubmed publisher
    ..The somatotropic axis is the main endocrine regulator of postnatal growth and may be affected by both ad libitum milk replacer (MR) feeding and B supplementation ..
  27. Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M. Selection system for genes encoding nuclear-targeted proteins. Nat Biotechnol. 1998;16:1338-42 pubmed
    ..We propose that NTT is an efficient method for isolating cDNAs that encode nuclear targeted proteins that can be applied to the retrieval of novel nuclear proteins and to annotate gene function. ..
  28. Mukhtar Y, Huang Y, Liu J, Chen D, Zheng W. Acetanilide and bromoacetyl-lysine derivatives as activators for human histone deacetylase 8. Bioorg Med Chem Lett. 2017;27:2319-2323 pubmed publisher
    ..e. 7) was found to decrease the KM of the above AMC-less HDAC8 substrate, while nearly maintaining the kcat of the HDAC8-catalyzed deacetylation on this substrate. ..
  29. Tao R, Kawate H, Wu Y, Ohnaka K, Ishizuka M, Inoue A, et al. Testicular zinc finger protein recruits histone deacetylase 2 and suppresses the transactivation function and intranuclear foci formation of agonist-bound androgen receptor competitively with TIF2. Mol Cell Endocrinol. 2006;247:150-65 pubmed
    We previously reported that testicular zinc finger protein (TZF) is a corepressor for androgen receptor (AR)...
  30. Ishizuka M, Kawate H, Takayanagi R, Ohshima H, Tao R, Hagiwara H. A zinc finger protein TZF is a novel corepressor of androgen receptor. Biochem Biophys Res Commun. 2005;331:1025-31 pubmed
    ..We found in this study that testicular zinc finger protein (TZF) that was a nuclear protein with a zinc finger motif of the Cys2-His2 type was a novel ..
  31. Inoue A, Ishiji A, Kasagi S, Ishizuka M, Hirose S, Baba T, et al. The transcript for a novel protein with a zinc finger motif is expressed at specific stages of mouse spermatogenesis. Biochem Biophys Res Commun. 2000;273:398-403 pubmed
    ..Our results suggest that this novel zinc finger protein might act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division. ..
  32. Smith E, Holt S, Hewitson T. FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-β autoinduction. Int J Biochem Cell Biol. 2017;92:63-78 pubmed publisher
    Bone-derived fibroblast growth factor 23 (FGF23) is an important endocrine regulator of mineral homeostasis with effects transduced by cognate FGF receptor (FGFR)1-α-Klotho complexes...
  33. Sheldon I, Cronin J, Pospiech M, Turner M. Symposium review: Mechanisms linking metabolic stress with innate immunity in the endometrium. J Dairy Sci. 2018;101:3655-3664 pubmed publisher
    ..are found when modulating the sensor of cellular nutrient satiety, mammalian target of rapamycin, or the endocrine regulator of metabolism, insulin-like growth factor-1...