TXNRD3

Summary

Gene Symbol: TXNRD3
Description: thioredoxin reductase 3
Alias: TGR, TR2, TRXR3, thioredoxin reductase 3, thioredoxin and glutathione reductase, thioredoxin glutathione reductase, thioredoxin reductase 2, thioredoxin reductase TR2
Species: human
Products:     TXNRD3

Top Publications

  1. Sun L, Zhang N, Zhu M, Zhao L, Zhou J, Qi D. Prevention of Aflatoxin B1 Hepatoxicity by Dietary Selenium Is Associated with Inhibition of Cytochrome P450 Isozymes and Up-Regulation of 6 Selenoprotein Genes in Chick Liver. J Nutr. 2016;: pubmed
    ..05) mRNA and/or activities of 6 selenoprotein genes (Gpx3, Txnrd1, Txnrd2, Txnrd3, iodothyronine deiodinase 2, and selenoprotein N) in the liver of AFB1-treated groups at week 2...
  2. Wang S, Yang S, Vlantis A, Liu S, Ng E, Chan A, et al. Expression of Antioxidant Molecules and Heat Shock Protein 27 in Thyroid Tumors. J Cell Biochem. 2016;117:2473-81 pubmed publisher
    ..The levels of manganese superoxide dismutase (MnSOD), thioredoxin reductase 2 (TXNRD2), glutathione (GSH), glutathione peroxidase (Gpx), catalase (CAT), and 27 kd heat-shock ..
  3. Schweizer U, Fradejas Villar N. Why 21? The significance of selenoproteins for human health revealed by inborn errors of metabolism. FASEB J. 2016;30:3669-3681 pubmed
    ..mutations in glutathione peroxidase 4 (GPX4) cause respiratory failure and bone defects, and mutations in thioredoxin reductase 2 (TXNRD2) are associated with familial glucocorticoid deficiency...
  4. White K, Kim M, Han C, Park H, Ding D, Boyd K, et al. Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice. Sci Rep. 2018;8:5039 pubmed publisher
    ..mitochondrial components from oxidative stress by supplying NADPH to both glutathione reductase (GSR) and thioredoxin reductase 2 (TXNRD2)...
  5. Vokurková M, Rauchová H, Řezáčová L, Vaněčková I, Zicha J. NADPH oxidase activity and reactive oxygen species production in brain and kidney of adult male hypertensive Ren-2 transgenic rats. Physiol Res. 2015;64:849-56 pubmed
    ..as well as in renal medulla and cortex of hypertensive male rats transgenic for the murine Ren-2 renin gene (Ren-2 TGR) and their age-matched normotensive controls - Hannover Sprague Dawley rats (HanSD)...
  6. Frenay A, Yu L, van der Velde A, Vreeswijk Baudoin I, López Andrés N, van Goor H, et al. Pharmacological inhibition of galectin-3 protects against hypertensive nephropathy. Am J Physiol Renal Physiol. 2015;308:F500-9 pubmed publisher
    ..Homozygous TGR(mREN)27 (REN2) rats develop severe high blood pressure (BP) and hypertensive end-organ damage, including ..
  7. Yan J, Xu J, Fei Y, Jiang C, Zhu W, Han Y, et al. TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species. Exp Cell Res. 2016;344:67-75 pubmed publisher
    b>Thioredoxin reductase 2 (TrxR2) is a selenium (Se) containing protein. Se deficiency is associated with an endemic osteoarthropathy characterized by impaired cartilage formation...
  8. Roksnoer L, van Veghel R, de Vries R, Garrelds I, Bhaggoe U, Friesema E, et al. Optimum AT1 receptor-neprilysin inhibition has superior cardioprotective effects compared with AT1 receptor blockade alone in hypertensive rats. Kidney Int. 2015;88:109-20 pubmed publisher
    ..a high dose of the neprilysin inhibitor thiorphan on top of AT1 receptor blockade with irbesartan versus vehicle in TGR(mREN2)27 rats with high renin hypertension...
  9. Aslam M, Horiuchi A, Simons J, Jha S, Yamada M, Odani T, et al. Engineering of the Hyperthermophilic Archaeon Thermococcus kodakarensis for Chitin-Dependent Hydrogen Production. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..To strengthen the glycolytic flux of KC04, the gene encoding Tgr (transcriptional repressor of glycolytic genes) was disrupted to obtain strain KC04Δt...

More Information

Publications117 found, 100 shown here

  1. Forred B, Daugaard D, Titus B, Wood R, Floen M, Booze M, et al. Detoxification of Mitochondrial Oxidants and Apoptotic Signaling Are Facilitated by Thioredoxin-2 and Peroxiredoxin-3 during Hyperoxic Injury. PLoS ONE. 2017;12:e0168777 pubmed publisher
    ..In conclusion, the mitochondrial thioredoxin system regulates hyperoxic-mediated death of pulmonary epithelial cells through detoxification of oxidants and regulation of redox-dependent apoptotic signaling. ..
  2. Rocha J, Rego N, Carvalho B, Silva F, Sousa J, Ramos R, et al. Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties. PLoS ONE. 2018;13:e0198476 pubmed publisher
    ..molecules were submitted to molecular docking calculations with the purine nucleoside phosphorylase, thioredoxin glutathione reductase, methylthioadenosine phosphorylase, arginase, uridine phosphorylase, Cathepsin B1 and histone ..
  3. Hinrichs S, Heger J, Schreckenberg R, Wenzel S, Euler G, Arens C, et al. Controlling cardiomyocyte length: the role of renin and PPAR-{gamma}. Cardiovasc Res. 2011;89:344-52 pubmed publisher
    ..transgenic mice with a cardiomyocyte-restricted knockout of PPAR-?, and transgenic rats overexpressing renin, TGR(mRen2)27. The length and width of cardiomyocytes were analysed 24 h after administration of factors...
  4. Bradshaw P. Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging. Nutrients. 2019;11: pubmed publisher
    ..an important role in the protection against redox stress and cell death and mitochondrial NADPH-utilizing thioredoxin reductase 2 levels correlate with species longevity in cells from rodents and primates...
  5. Roksnoer L, van Veghel R, van Groningen M, de Vries R, Garrelds I, Bhaggoe U, et al. Blood pressure-independent renoprotection in diabetic rats treated with AT1 receptor-neprilysin inhibition compared with AT1 receptor blockade alone. Clin Sci (Lond). 2016;130:1209-20 pubmed publisher
    ..We hypothesized that ARNI improves cardiac and kidney parameters in diabetic TGR(mREN2)27 rats, an angiotensin II-dependent hypertension model...
  6. Lumicisi B, Cartwright J, Leslie K, Wallace A, Whitley G. Inhibition of DDAH1, but not DDAH2, results in apoptosis of a human trophoblast cell line in response to TRAIL. Hum Reprod. 2015;30:1813-9 pubmed publisher
    ..increased sensitivity to apoptosis is accompanied by a significant increase in the expression of TRAIL receptor 2 (TR2; P < 0.05) but not TRAIL receptor 1 (TR1)...
  7. Flück C. MECHANISMS IN ENDOCRINOLOGY: Update on pathogenesis of primary adrenal insufficiency: beyond steroid enzyme deficiency and autoimmune adrenal destruction. Eur J Endocrinol. 2017;177:R99-R111 pubmed publisher
    ..more recently novel mutations in genes such as nicotinamide nucleotide transhydrogenase (NNT) and thioredoxin reductase 2 (TRXR2) involved in the maintenance of the mitochondrial redox potential and generation of NADPH ..
  8. Kiermayer C, Northrup E, Schrewe A, Walch A, de Angelis M, Schoensiegel F, et al. Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium. J Am Heart Assoc. 2015;4: pubmed publisher
    Ubiquitous deletion of thioredoxin reductase 2 (Txnrd2) in mice is embryonically lethal and associated with abnormal heart development, while constitutive, heart-specific Txnrd2 inactivation leads to dilated cardiomyopathy and perinatal ..
  9. Xu Z, Zhang Y, Ding J, Hu W, Tan C, Wang M, et al. miR-17-3p Downregulates Mitochondrial Antioxidant Enzymes and Enhances the Radiosensitivity of Prostate Cancer Cells. Mol Ther Nucleic Acids. 2018;13:64-77 pubmed publisher
    ..e., manganese superoxide dismutase (MnSOD), glutathione peroxidase 2 (Gpx2), and thioredoxin reductase 2 (TrxR2)...
  10. Kirsch J, Schneider H, Pagel J, Rehberg M, Singer M, Hellfritsch J, et al. Endothelial Dysfunction, and A Prothrombotic, Proinflammatory Phenotype Is Caused by Loss of Mitochondrial Thioredoxin Reductase in Endothelium. Arterioscler Thromb Vasc Biol. 2016;36:1891-9 pubmed publisher
    ..dysregulated redox homeostasis by examining the effects of endothelial cell-specific deletion of murine thioredoxin reductase 2 (Txnrd2), a key enzyme of mitochondrial redox control...
  11. Mythen S, Devendran S, Méndez García C, Cann I, Ridlon J. Targeted Synthesis and Characterization of a Gene Cluster Encoding NAD(P)H-Dependent 3?-, 3?-, and 12?-Hydroxysteroid Dehydrogenases from Eggerthella CAG:298, a Gut Metagenomic Sequence. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..In this regard, we have identified a novel 12?-HSDH and a novel set of genes encoding an iso-bile acid pathway (3?-HSDH and 3?-HSDH) involved in epimerization and detoxification of harmful secondary bile acids. ..
  12. Turanov A, Kehr S, Marino S, Yoo M, Carlson B, Hatfield D, et al. Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets. Biochem J. 2010;430:285-93 pubmed publisher
    ..Three TRs have been identified in mammals: (i) cytosolic TR1, (ii) mitochondrial TR3 and (iii) testes-specific TGR (Trx-glutathione reductase)...
  13. Buttgereit J, Shanks J, Li D, Hao G, Athwal A, Langenickel T, et al. C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function. Cardiovasc Res. 2016;112:637-644 pubmed
    ..05) elevated in freely moving TGRs (n = 9) compared with Sprague Dawley (SD) controls (n = 10). TGR had impaired left ventricular systolic function and spectral analysis of HR variability suggested a shift towards ..
  14. Senger N, Melo M, Diniz G, Campagnole Santos M, Santos R, Barreto Chaves M. Angiotensin-(1-7) reduces cardiac effects of thyroid hormone by GSK3?/NFATc3 signaling pathway. Clin Sci (Lond). 2018;132:1117-1133 pubmed publisher
    ..in a transgenic rat (TG) model that constitutively overexpresses an Ang-(1-7)-producing fusion protein [TGR(A1-7)3292]. TG and wild-type (WT) rats received daily injections (i.p...
  15. Scalcon V, Bindoli A, Rigobello M. Significance of the mitochondrial thioredoxin reductase in cancer cells: An update on role, targets and inhibitors. Free Radic Biol Med. 2018;127:62-79 pubmed publisher
    b>Thioredoxin reductase 2 (TrxR2) is a key component of the mitochondrial thioredoxin system able to transfer electrons to peroxiredoxin 3 (Prx3) in a reaction mediated by thioredoxin 2 (Trx2)...
  16. Plancarte A, Nava G, Munguía J. A new thioredoxin reductase with additional glutathione reductase activity in Haemonchus contortus. Exp Parasitol. 2017;177:82-92 pubmed publisher
    ..Although HcTrxR3 has both TrxR and GR activity as thioredoxin glutathione reductase (TGR) does, it is a TrxR because it has no glutaredoxin domain and it does not develop any ..
  17. Long A, Lemieux C, Arlt V, White P. Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the Muta™Mouse transgenic rodent assay. Toxicol Appl Pharmacol. 2016;290:31-42 pubmed publisher
    ..An OECD test guideline for transgenic rodent (TGR) gene mutation assays was released in 2011, and the TGR assays permit assessment of mutagenicity in any tissue...
  18. Tinkov A, Bjørklund G, Skalny A, Holmgren A, Skalnaya M, Chirumbolo S, et al. The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker?. Cell Mol Life Sci. 2018;75:1567-1586 pubmed publisher
    Mammalian thioredoxin reductase (TrxR) is a selenoprotein with three existing isoenzymes (TrxR1, TrxR2, and TrxR3), which is found primarily intracellularly but also in extracellular fluids...
  19. Zucker S, Fink E, Bagati A, Mannava S, Bianchi Smiraglia A, Bogner P, et al. Nrf2 amplifies oxidative stress via induction of Klf9. Mol Cell. 2014;53:916-928 pubmed publisher
    ..and alters the expression of several genes involved in the metabolism of ROS, including suppression of thioredoxin reductase 2, an enzyme participating in ROS clearance...
  20. Cunniff B, Newick K, NELSON K, Wozniak A, Beuschel S, Leavitt B, et al. Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma. PLoS ONE. 2015;10:e0127310 pubmed publisher
    ..the adverse effects of mitochondrial peroxide many solid tumor types up-regulate the mitochondrial thioredoxin reductase 2--thioredoxin 2 (TRX2)--peroxiredoxin 3 (PRX3) antioxidant network...
  21. Hlaváčová M, Gumulec J, Stračina T, Fojtů M, Raudenská M, Masařík M, et al. Different doxorubicin formulations affect plasma 4-hydroxy-2-nonenal and gene expression of aldehyde dehydrogenase 3A1 and thioredoxin reductase 2 in rat. Physiol Res. 2015;64 Suppl 5:S653-60 pubmed
    ..plasma level of 4-hydroxy-2-nonenal (4-HNE) as a marker of lipoperoxidation and tissue gene expression of thioredoxin reductase 2 (TXNRD2) and aldehyde dehydrogenase 3A1 (ALDH3A1) as an important part of antioxidative system were ..
  22. Tripathi T, Suttiprapa S, Sripa B. Unusual thiol-based redox metabolism of parasitic flukes. Parasitol Int. 2017;66:390-395 pubmed publisher
    ..One of the redox-sensitive enzymes, thioredoxin glutathione reductase (TGR), has been accepted as a drug target against blood fluke infections, and related clinical ..
  23. Gladyshev V, Arnér E, Berry M, Brigelius Flohe R, Bruford E, Burk R, et al. Selenoprotein Gene Nomenclature. J Biol Chem. 2016;291:24036-24040 pubmed
    ..Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (..
  24. Tian B, Maidana D, Dib B, Miller J, Bouzika P, Miller J, et al. miR-17-3p Exacerbates Oxidative Damage in Human Retinal Pigment Epithelial Cells. PLoS ONE. 2016;11:e0160887 pubmed publisher
    ..These results suggest miR-17-3p aggravates oxidative damage-induced cell death in human RPE cells, while miR-17-3p inhibitor acts as a potential protector against oxidative stress by regulating the expression of antioxidant enzymes. ..
  25. Khoso P, Yang Z, Liu C, Li S. Selenoproteins and heat shock proteins play important roles in immunosuppression in the bursa of Fabricius of chickens with selenium deficiency. Cell Stress Chaperones. 2015;20:967-78 pubmed publisher
    ..The data showed that the mRNA expression levels of selenoproteins, such as Txnrd1, Txnrd2, Txnrd3, Dio1, Dio2, Dio3, GPx1, GPx2, GPx3 GPx4, Sepp1, Selo, Sel-15, Sepx1, Sels, Seli, Selu, Selh, and SPS2, were ..
  26. Zhang J, Li Y, Duan D, Yao J, Gao K, Fang J. Inhibition of thioredoxin reductase by alantolactone prompts oxidative stress-mediated apoptosis of HeLa cells. Biochem Pharmacol. 2016;102:34-44 pubmed publisher
    The mammalian thioredoxin reductase (TrxR) isoenzymes, TrxR1 in cytosol or nucleus, TrxR2 in mitochondria, and TrxR3 in testis, are essential seleno-flavoenzymes with a conserved penultimate selenocysteine (Sec) residue at the C-terminus,..
  27. Roksnoer L, Uijl E, de Vries R, Garrelds I, Jan Danser A. Neprilysin inhibition and endothelin-1 elevation: Focus on the kidney. Eur J Pharmacol. 2018;824:128-132 pubmed publisher
    ..However, the neprilysin inhibitor thiorphan was recently found to increase endothelin-1 when administered to TGR(mREN2)27 (Ren2) rats on top of RAS blockade...
  28. Dondelinger E, Aubry N, Ben Chaabane F, Cohen C, Tayeb J, Rémond C. Contrasted enzymatic cocktails reveal the importance of cellulases and hemicellulases activity ratios for the hydrolysis of cellulose in presence of xylans. AMB Express. 2016;6:24 pubmed publisher
    ..Cocktails TR2 and TR5 which were produced on the higher amount of hemicellulosic hydrolysate, possess both high xylanase and ?-..
  29. Luan Y, Ruan Y, Wang T, Zhuan L, Wen Z, Chen R, et al. Preserved Erectile Function in the Aged Transgenic Rat Harboring Human Tissue Kallikrein 1. J Sex Med. 2016;13:1311-1322 pubmed publisher
    ..Male wild-type Sprague-Dawley rats (WTR) and transgenic rats harboring the hKLK1 gene (TGR) were fed to 4 and 27 months of age, respectively, and divided into four groups: young WTR (yWTR) as the control, ..
  30. Bouraima A, He B, Tian T. Runoff, nitrogen (N) and phosphorus (P) losses from purple slope cropland soil under rating fertilization in Three Gorges Region. Environ Sci Pollut Res Int. 2016;23:4541-50 pubmed publisher
    ..winter wheat-summer maize, on a 15° slope purple soil in Chongqing (China) within the Three Gorges Region (TGR)...
  31. Cui K, Luan Y, Tang Z, Rao K, Wang T, Chen Z, et al. Involvement of DDAH/ADMA/NOS/cGMP and COX-2/PTGIS/cAMP Pathways in Human Tissue Kallikrein 1 Protecting Erectile Function in Aged Rats. PLoS ONE. 2017;12:e0170427 pubmed publisher
    ..the latent mechanism, male wild-type Sprague-Dawley rats (WTR) and transgenic rats harboring the hKLK1 gene (TGR) were fed to 4 and 18 months old and divided into four groups: young WTR (yWTR) as the control, aged WTR (aWTR), ..
  32. Ma Z, Zhao Y, Yao Y, Lei Z, Jin M, Li X, et al. Postnatal developmental of Neuromedin S and its receptor in the male Xiaomeishan pig reproductive axis. Anim Reprod Sci. 2017;181:115-124 pubmed publisher
    Neuromedin S (NMS) has been identified as an endogenous ligand for FM-3/GPR66 and FM-4/TGR-1 which are NMU receptors NMUR1 and NMUR2, respectively...
  33. Su X, Nilsson C, Pilotto F, Liu S, Shi S, Zeng B. Soil erosion and deposition in the new shorelines of the Three Gorges Reservoir. Sci Total Environ. 2017;599-600:1485-1492 pubmed publisher
    ..We explored the factors regulating soil dynamics in the shorelines of the Three Gorges Reservoir (TGR) on the Yangtze River in China...
  34. Winkler M, Bader M, Schuster F, Stölting I, Binder S, Raasch W. Development of obesity can be prevented in rats by chronic icv infusions of AngII but less by Ang(1-7). Pflugers Arch. 2018;470:867-881 pubmed publisher
    ..Additionally to Sprague Dawley (SD) rats, we used TGR(ASrAOGEN) selectively lacking brain angiotensinogen, the precursor to AngII, as we speculated that effects are more ..
  35. Zhou B, Shang M, Wang G, Zhang S, Feng L, Liu X, et al. Distinguishing two phenotypes of blooms using the normalised difference peak-valley index (NDPI) and Cyano-Chlorophyta index (CCI). Sci Total Environ. 2018;628-629:848-857 pubmed publisher
    ..of cyanobacterial and green algal blooms in Lakes Gaoyang, Hanfeng and Changshou of the Three Gorges Reservoir (TGR) in China were recorded...
  36. Floehr T, Scholz Starke B, Xiao H, Hercht H, Wu L, Hou J, et al. Linking Ah receptor mediated effects of sediments and impacts on fish to key pollutants in the Yangtze Three Gorges Reservoir, China - A comprehensive perspective. Sci Total Environ. 2015;538:191-211 pubmed publisher
    The Three Gorges Reservoir (TGR), created in consequence of the Yangtze River's impoundment by the Three Gorges Dam, faces numerous anthropogenic impacts that challenge its unique ecosystem...
  37. Welling W, Benjaminse A, Gokeler A, Otten B. Enhanced retention of drop vertical jump landing technique: A randomized controlled trial. Hum Mov Sci. 2016;45:84-95 pubmed publisher
    ..Landing was assessed from a drop vertical jump (DVJ) in five sessions: pretest, two training blocks (TR1 and TR2) and directly after the training sessions (post test) and retention test 1week later...
  38. Gupta A, Kesherwani M, Velmurugan D, Tripathi T. Fasciola gigantica thioredoxin glutathione reductase: Biochemical properties and structural modeling. Int J Biol Macromol. 2016;89:152-60 pubmed publisher
    Platyhelminth thioredoxin glutathione reductase (TGR) is a multifunctional enzyme that crosstalk between the conventional thioredoxin (Trx) and glutathione (GSH) system. It has been validated as a potential drug target in blood flukes...
  39. Du H, Ma M, Sun T, Dai X, Yang C, Luo F, et al. Mercury-methylating genes dsrB and hgcA in soils/sediments of the Three Gorges Reservoir. Environ Sci Pollut Res Int. 2017;24:5001-5011 pubmed publisher
    Previous research found that the water-level fluctuating zone (WLFZ) of the Three Gorges Reservoir (TGR) was an Hg-sensitive area...
  40. Nie Y, Zhang Z, Wang M, Shen Q, Li Y, Gao W, et al. Seasonal variations of carbonic anhydrase activity in Chongqing urban section of Jialing River and its influencing factors. Chemosphere. 2017;179:202-212 pubmed publisher
    ..CAA) and its change mechanism in the hydro-fluctuation belt of the tributaries in the Three Gorges Reservoir (TGR) area...
  41. Wintermantel W, Gilbertson R, Natwick E, McCreight J. Emergence and epidemiology of Cucurbit yellow stunting disorder virus in the American Desert Southwest, and development of host plant resistance in melon. Virus Res. 2017;241:213-219 pubmed publisher
    ..313970 was identified as a new source of host plant resistance to CYSDV, in addition to the previously identified TGR 1551 (=PI 482420) and TGR 1937 (=PI 482431)...
  42. Kalita P, Shukla H, Shukla R, Tripathi T. Biochemical and thermodynamic comparison of the selenocysteine containing and non-containing thioredoxin glutathione reductase of Fasciola gigantica. Biochim Biophys Acta Gen Subj. 2018;1862:1306-1316 pubmed publisher
    ..in platyhelminth parasites depends entirely on a single selenocysteine (Sec) containing flavoenzyme, thioredoxin glutathione reductase (TGR) that links the classical thioredoxin (Trx) and glutathione (GSH) systems...
  43. Zhang J, Xu B, Huang X, Gao Y, Chen Y, Shan A. Selenium Deficiency Affects the mRNA Expression of Inflammatory Factors and Selenoprotein Genes in the Kidneys of Broiler Chicks. Biol Trace Elem Res. 2016;171:201-7 pubmed publisher
    ..SelW, Sep15, SelT, SelU, and SelS) decreased, and 9 selenoprotein genes (GPx1, GPx2, GPx4, SelPb, Txnrd1, Txnrd2, Txnrd3, SPS2, and SelM) increased in L group (p < 0.05), but the Dio3 and Sepx1 mRNA levels did not change...
  44. Yang Z, Liu C, Liu C, Teng X, Li S. Selenium Deficiency Mainly Influences Antioxidant Selenoproteins Expression in Broiler Immune Organs. Biol Trace Elem Res. 2016;172:209-21 pubmed publisher
    ..we found that among 23 selenoproteins, the mRNA levels of Dio1 in the thymus, Txnrd2 in the spleen, and Txnrd3 in the bursa of Fabricius decreased significantly (90.9 %, 83.3 %, and 96.8 %, respectively)...
  45. Lou B, Yin S. Spatial and seasonal distribution of phosphorus in the mainstem within the Three Gorges Reservoir before and after impoundment. Water Sci Technol. 2016;73:636-42 pubmed publisher
    The Three Gorges Reservoir (TGR) began to store water in 2003. The water level reached 135 m in 2003, 156 m in 2006, 172 m in 2008 and 175 m (target level) in every year from 2010 through 2013...
  46. Chen Z, Schaffer A. The fate of the herbicide propanil in plants of the littoral zone of the Three Gorges Reservoir (TGR), China. J Environ Sci (China). 2016;48:24-33 pubmed publisher
    The anti-seasonal hydrology with 30m water fluctuations in the Three Gorges Reservoir (TGR) of China attracts growing environmental and ecological concerns...
  47. Han L, Gao B, Wei X, Gao L, Xu D, Sun K. The characteristic of Pb isotopic compositions in different chemical fractions in sediments from Three Gorges Reservoir, China. Environ Pollut. 2015;206:627-35 pubmed publisher
    To explore the distribution and sources of Pb within the Three Gorges Reservoir (TGR), Pb concentrations and isotope ratios were measured in sediment cores collected from one mainstream and three tributaries...
  48. Li B, Du C, Yuan X, Willison J, Xiao H. Suitability of Taxodium distichum for Afforesting the Littoral Zone of the Three Gorges Reservoir. PLoS ONE. 2016;11:e0146664 pubmed publisher
    The littoral zone ecosystem of the Three Gorges Reservoir (TGR) has become significantly degraded by annual cycles of prolonged winter flooding and summer drought...
  49. Bracalente C, Ibañez I, Berenstein A, Notcovich C, Cerda M, Klamt F, et al. Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Upregulation of antioxidant genes correlates with regression of melanoma malignancy and with malignant progression when downregulated. Oncotarget. 2016;7:41154-41171 pubmed publisher
    ..Moreover, differential coexpression of AOS genes (EPHX2, GSTM3, MGST1, MSRA, TXNRD3, MGST3 and GSR) was found in A7 and G10...
  50. Cui K, Luan Y, Wang T, Zhuan L, Rao K, Wang S, et al. Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1. Asian J Androl. 2017;19:67-72 pubmed publisher
    Our previous studies have demonstrated that erectile function was preserved in aged transgenic rats (TGR) harboring the human tissue kallikrein 1 (hKLK1), while the molecular level of hKLK1 on corporal fibrosis to inhibit age-related ..
  51. Upasani V, Parvaresh K, Pawelek J, Miller P, Thompson G, Skaggs D, et al. Age at Initiation and Deformity Magnitude Influence Complication Rates of Surgical Treatment With Traditional Growing Rods in Early-Onset Scoliosis. Spine Deform. 2016;4:344-350 pubmed publisher
    ..with postoperative complications in early-onset scoliosis (EOS) patients treated with traditional growing rods (TGR); and to develop a model to predict the incidence of postoperative complications based on preoperative variables...
  52. Gao L, Gao B, Xu D, Peng W, Lu J, Gao J. Assessing remobilization characteristics of arsenic (As) in tributary sediment cores in the largest reservoir, China. Ecotoxicol Environ Saf. 2017;140:48-54 pubmed publisher
    The environmental impact of the Three Gorges Reservoir (TGR) in China has raised widespread concern especially in relation to metal pollution...
  53. Zinzani P, Broccoli A. Possible novel agents in marginal zone lymphoma. Best Pract Res Clin Haematol. 2017;30:149-157 pubmed publisher
    ..such as obinutuzumab, ibrutinib and idelalisib, and of some very new drugs (venetoclax, copanlisib, ublituximab and TGR-1202) is also discussed, taking into account the most relevant experiences in patients with indolent non-Hodgkin's ..
  54. Zhang J, Li S, Dong R, Jiang C. Physical evolution of the Three Gorges Reservoir using advanced SVM on Landsat images and SRTM DEM data. Environ Sci Pollut Res Int. 2018;25:14911-14918 pubmed publisher
    The Three Gorges Reservoir (TGR) is one of the largest hydropower reservoirs in the world. However, changes of the important physical characteristics of the reservoir covering pre-, during-, and post- dam have not been well studied...
  55. Martínez González J, Guevara Flores A, Rendón J, Arenal I. Auranofin-induced oxidative stress causes redistribution of the glutathione pool in Taenia crassiceps cysticerci. Mol Biochem Parasitol. 2015;201:16-25 pubmed publisher
    ..Previously, we have studied the effect of the gold-compound auranofin (AF) on both thioredoxin-glutathione reductasa (TGR) activity and viability of Taenia crassiceps cysticerci...
  56. Li T, Ziniel P, He P, Kommer V, Crowther G, He M, et al. High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis. Infect Dis Poverty. 2015;4:40 pubmed publisher
    ..mansoni). Thioredoxin glutathione reductase (TGR) from S...
  57. Vaněčková I, Řezáčová L, Kuneš J, Zicha J. Moderate additive effects of endothelin receptor A blockade in Ren-2 transgenic rats subjected to various types of RAS blockade. Life Sci. 2016;159:127-134 pubmed publisher
    ..have further effects on the principal vasoactive systems contributing to BP maintenance in Ren-2 transgenic rats (TGR)...
  58. Li X, Xing M, Chen M, Zhao J, Fan R, Zhao X, et al. Effects of selenium-lead interaction on the gene expression of inflammatory factors and selenoproteins in chicken neutrophils. Ecotoxicol Environ Saf. 2017;139:447-453 pubmed publisher
    ..Pb in chicken serum, mRNA levels of 24 selenoproteins (GPX1, GPX2, GPX3, GPX4, Dio1, Dio2, Dio3, Txnrd1, Txnrd2, Txnrd3, SELS, SPS2, SELK, SELW1, SEP15, SEPX1, SELT, SELI, SELO, SELM, SEPN1, SEPP1, SELU, SELH) and inflammatory factors ..
  59. Huang Y, Yasarer L, Li Z, Sturm B, Zhang Z, Guo J, et al. Air-water CO2 and CH4 fluxes along a river-reservoir continuum: Case study in the Pengxi River, a tributary of the Yangtze River in the Three Gorges Reservoir, China. Environ Monit Assess. 2017;189:223 pubmed publisher
    ..field survey was carried out in the Pengxi River-reservoir continuum, a part of the Three Gorges Reservoir (TGR) immediately after the TGR reached its maximum water level...
  60. Wang X, Bao R, Fu J. The Antagonistic Effect of Selenium on Cadmium-Induced Damage and mRNA Levels of Selenoprotein Genes and Inflammatory Factors in Chicken Kidney Tissue. Biol Trace Elem Res. 2018;181:331-339 pubmed publisher
    ..TNF-?), and cyclooxygenase-2 (COX-2)) and 25 selenoprotein genes (Gpx1, Gpx2, Gpx3, Gpx4, Txnrd1, Txnrd2, Txnrd3, Dio1, Dio2, Dio3, SPS2, Sepp1, SelPb, Sep15, Selh, Seli, Selm, Selo, Sels, Sepx1, Selu, Selk, Selw, Seln, Selt)...
  61. Olivares A, Han Y, Soto D, Flattery K, Marini J, Mollema N, et al. The nuclear hormone receptor gene Nr2c1 (Tr2) is a critical regulator of early retina cell patterning. Dev Biol. 2017;429:343-355 pubmed publisher
    ..This study uncovers a novel role for testicular receptor 2 (Tr2, Nr2c1) in defining the early phase of retinal development and regulating normal retinal cell patterning and ..
  62. Tang J, Wang T, Zhu B, Zhao P, Xiao Y, Wang R. Tempo-spatial analysis of water quality in tributary bays of the Three Gorges Reservoir region (China). Environ Sci Pollut Res Int. 2015;22:16709-20 pubmed publisher
    As a giant newly built man-made canyon-shaped reservoir, the Three Gorges Reservoir (TGR) receives much attention around China and other parts of the world...
  63. Liu Y, Willison J, Wan P, Xiong X, Ou Y, Huang X, et al. Mulberry trees conserved soil and protected water quality in the riparian zone of the Three Gorges Reservoir, China. Environ Sci Pollut Res Int. 2016;23:5288-95 pubmed publisher
    ..to restore perennial plant cover on sloping land in western China, in part to protect the Three Gorges Reservoir (TGR). In this study, we examined use of white mulberry (Morus alba L...
  64. Inaparthy P, Queruz J, Bhagawati D, Thakar C, Subramanian T, Nnadi C. Incidence of proximal junctional kyphosis with magnetic expansion control rods in early onset scoliosis. Eur Spine J. 2016;25:3308-3315 pubmed
    ..3/6 patients (50 %) were conversion cases treated with traditional growth rods previously (TGR). None of the patients required unplanned surgery for PJK...
  65. Maina A, Fogarty C, Krueger L, Macaluso K, Odhiambo A, Nguyen K, et al. Rickettsial Infections among Ctenocephalides felis and Host Animals during a Flea-Borne Rickettsioses Outbreak in Orange County, California. PLoS ONE. 2016;11:e0160604 pubmed publisher
    ..In addition, we assessed the prevalence of IgG antibodies against spotted fever group (SFGR) and typhus group (TGR) rickettsiae in opossum sera. Of the 597 flea specimens collected from opossums and cats, 37...
  66. Chen W, Li X, Wu Y, Bian J, Shen J, Jiang W, et al. Associations between iodine intake, thyroid volume, and goiter rate in school-aged Chinese children from areas with high iodine drinking water concentrations. Am J Clin Nutr. 2017;105:228-233 pubmed publisher
    ..water on thyroid size in children by examining associations between thyroid volume (Tvol), total goiter rate (TGR), and iodine intake...
  67. Wu Q, Han G. ?13CDIC tracing of dissolved inorganic carbon sources at Three Gorges Reservoir, China. Water Sci Technol. 2018;77:555-564 pubmed publisher
    In order to understand water chemistry after impoundment of the Three Gorges Reservoir (TGR), the authors assessed the hydrogeochemical parameters (water temperature, pH, conductivity, dissolved O2), major element composition, ..
  68. Huang L, Fang H, Reible D. Mathematical model for interactions and transport of phosphorus and sediment in the Three Gorges Reservoir. Water Res. 2015;85:393-403 pubmed publisher
    ..evaluate the effects of various operating rules on sediment and phosphorus retention in the Three Gorges Reservoir (TGR)...
  69. Omballa V, Musyoka R, Vittor A, Wamburu K, Wachira C, Waiboci L, et al. Serologic Evidence of the Geographic Distribution of Bacterial Zoonotic Agents in Kenya, 2007. Am J Trop Med Hyg. 2016;94:43-51 pubmed publisher
    ..spotted fever group rickettsioses (SFGR), and typhus group rickettsioses (TGR) from samples of persons aged 15-64 years collected during a nationwide human immunodeficiency virus (HIV) ..
  70. Gao H, Liu C, Song S, Fu J. Effects of Dietary Selenium Against Lead Toxicity on mRNA Levels of 25 Selenoprotein Genes in the Cartilage Tissue of Broiler Chicken. Biol Trace Elem Res. 2016;172:234-41 pubmed publisher
    ..In detail, Se could alleviate the downtrend of the expression of Gpx1, Gpx2, Gpx4, Txnrd2, Txnrd3, Dio1, Dio2, Seli, Selu, Sepx1, Selk, Selw, Selo, Selm, Sep15, Sepnn1, Sels, and Selt induced by Pb exposure in ..
  71. Gao L, Gao B, Zhou H, Xu D, Wang Q, Yin S. Assessing the remobilization of Antimony in sediments by DGT: A case study in a tributary of the Three Gorges Reservoir. Environ Pollut. 2016;214:600-607 pubmed publisher
    The Three Gorges Reservoir (TGR) is one of the world's largest man-made hydropower projects, which has posed great challenges to the aquatic environment of the Yangtze River since the impoundment of water...
  72. Lei G, Xu M, Xu Z, Lü C, Tan S. Combination of novel DR5 targeting agonistic scFv antibody TR2-3 with cisplatin shows enhanced synergistic antitumor activity in vitro and in vivo. Biomed Pharmacother. 2018;98:271-279 pubmed publisher
    To investigate the antitumor activity of a novel agonistic single chain fragment variable (scFv) antibody TR2-3 targeting death receptor 5 (DR5) combined with cisplatin in vitro and in vivo...
  73. Rijsdijk M, Agalave N, van Wijck A, Kalkman C, Ramachandran R, Baharpoor A, et al. Effect of intrathecal glucocorticoids on the central glucocorticoid receptor in a rat nerve ligation model. Scand J Pain. 2017;16:1-9 pubmed publisher
    ..receptor, we explored the effects of intrathecal methylprednisolone acetate (MPA) on total glucocorticoid receptor (tGR) levels and activation of the glucocorticoid receptor (phosphorylated state=pGR) within the spinal dorsal horn (SDH)..
  74. Temoka P, Pfister G, Henkelmann B, Schramm K. Adapting current model with field data of related performance reference compounds in passive samplers to accurately monitor hydrophobic organic compounds in aqueous media. Environ Monit Assess. 2017;189:543 pubmed publisher
    ..an empirical model during sampling campaign in 2011 with VO in 12 different sites along the Three Gorges Reservoir (TGR) in China. A discrepancy was observed for high hydrophobic compounds with log K ow ranging from 5...
  75. Marxreiter S, Thummel C. Adult functions for the Drosophila DHR78 nuclear receptor. Dev Dyn. 2017;: pubmed publisher
    The Testicular Receptors 2 and 4 (TR2, TR4) comprise a small subfamily of orphan nuclear receptors...
  76. Gerashchenko M, Su D, Gladyshev V. CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes. J Biol Chem. 2010;285:4595-602 pubmed publisher
    ..Thioredoxin/glutathione reductase (TGR) is a third member of this enzyme family...
  77. Liu Q, Yang J, Cai J, Luan Y, Sattar H, Liu M, et al. Analysis of the Interactions Between Thioredoxin and 20 Selenoproteins in Chicken. Biol Trace Elem Res. 2017;179:304-317 pubmed publisher
    ..selenoprotein 15 (Sep15), methionine sulfoxide reductase B (Sepx1), selenophosphate synthetase 1 (SPS1), TR1, TR2, and TR3, among which TR1, TR2, TR3, SPS1, Sep15, SelN, SelM, SelI, Gpx2, Gpx3, Gpx4, and Dio3 exhibited intense ..
  78. Benjaminse A, Welling W, Otten B, Gokeler A. Transfer of improved movement technique after receiving verbal external focus and video instruction. Knee Surg Sports Traumatol Arthrosc. 2018;26:955-962 pubmed publisher
    ..A jump-landing task was performed as baseline followed by training blocks (TR1 and TR2) and a post-test. Group-specific instructions were given in TR1 and TR2...
  79. Nouri Saeidlou S, Babaei F, Ayremlou P, Entezarmahdi R. Has iodized salt reduced iodine-deficiency disorders among school-aged children in north-west Iran? A 9-year prospective study. Public Health Nutr. 2017;:1-8 pubmed publisher
    ..We aimed to assess total goitre rate (TGR) and urinary iodine concentration (UIC) in schoolchildren between 2007 and 2015, percentage of iodized salt ..
  80. Mojib N, Xu J, Bartolek Z, Imhoff B, McCarty N, Shin C, et al. Zebrafish aversive taste co-receptor is expressed in both chemo- and mechanosensory cells and plays a role in lateral line development. Sci Rep. 2017;7:13475 pubmed publisher
    ..small co-receptor from zebrafish, receptor activity modifying protein (RAMP)-like triterpene glycoside receptor (RL-TGR), was previously found to be involved in recognition of triterpene glycosides, a family of naturally occurring ..
  81. Wang H, Shi G, Tian M, Chen Y, Qiao B, Zhang L, et al. Wet deposition and sources of inorganic nitrogen in the Three Gorges Reservoir Region, China. Environ Pollut. 2018;233:520-528 pubmed publisher
    Precipitation samples were collected at five rural and one urban sites in the Three Gorges Reservoir Region (TGR), China from March 2014 to February 2016...
  82. Springate J, Feld L, Ganten D. Renal function in hypertensive rats transgenic for mouse renin gene. Am J Physiol. 1994;266:F731-7 pubmed
    The recent development of a transgenic rat strain carrying the mouse ren-2 renin gene [TGR(mRen2)27] has provided a new model of hypertension characterized by suppressed plasma renin levels and marked hyperproreninemia...
  83. Sun Q, Kirnarsky L, Sherman S, Gladyshev V. Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems. Proc Natl Acad Sci U S A. 2001;98:3673-8 pubmed
    ..We cloned and characterized a pyridine nucleotide disulfide oxidoreductase, Trx and GSSG reductase (TGR), that exhibits specificity for both redox systems...
  84. Wills J, Johnson G, Battaion H, Slob W, White P. Comparing BMD-derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay. Environ Mol Mutagen. 2017;58:632-643 pubmed publisher
    ..Currently, multiple transgenic rodent (TGR) assay variants, employing different rodent strains and reporter transgenes, are used for the assessment of ..
  85. He M, Yang T, Yang Z, Zhou H, Wei S. Current State, Distribution, and Sources of Phthalate Esters and Organophosphate Esters in Soils of the Three Gorges Reservoir Region, China. Arch Environ Contam Toxicol. 2018;74:502-513 pubmed publisher
    ..were identified and quantified in surface soils from farmland and riparian areas of the Three Gorges Reservoir (TGR), western China...
  86. Liu J, Jiang T, Wang F, Zhang J, Wang D, Huang R, et al. Inorganic sulfur and mercury speciation in the water level fluctuation zone of the Three Gorges Reservoir, China: The role of inorganic reduced sulfur on mercury methylation. Environ Pollut. 2018;237:1112-1123 pubmed publisher
    The water level fluctuation zone (WLFZ) of the Three Gorges Reservoir (TGR) in China is a unique geomorphological unit that undergoes annual flooding and drying alternation cycle...
  87. Kryukov G, Castellano S, Novoselov S, Lobanov A, Zehtab O, Guig R, et al. Characterization of mammalian selenoproteomes. Science. 2003;300:1439-43 pubmed publisher
    ..The human selenoproteome consists of 25 selenoproteins...
  88. Pickering A, Lehr M, Gendron C, Pletcher S, Miller R. Mitochondrial thioredoxin reductase 2 is elevated in long-lived primate as well as rodent species and extends fly mean lifespan. Aging Cell. 2017;16:683-692 pubmed publisher
    ..species reflected increases in the mitochondrial form, TXNRD2, rather than the cytosolic forms TXNRD1 and TXNRD3. Analysis of published RNA-Seq data showed elevated TXNRD2 mRNA in multiple organs of longer-lived primates, ..
  89. Di M, Wang J. Microplastics in surface waters and sediments of the Three Gorges Reservoir, China. Sci Total Environ. 2018;616-617:1620-1627 pubmed publisher
    We investigated microplastic pollution levels in surface waters and sediments from the Three Gorges Reservoir (TGR). The TGR is the largest reservoir in China and is located across the Chongqing municipality and Hubei Province...
  90. Shukla R, Shukla H, Kalita P, Tripathi T. Structural insights into natural compounds as inhibitors of Fasciola gigantica thioredoxin glutathione reductase. J Cell Biochem. 2017;: pubmed publisher
    Fascioliasis is caused by the helminth parasites of genus Fasciola. Thioredoxin glutathione reductase (TGR) is an important enzyme in parasitic helminths and plays an indispensable role in its redox biology...
  91. Liu Y, Cao X, Li H, Zhou Z, Wang S, Wang Z, et al. Distribution of phosphorus-solubilizing bacteria in relation to fractionation and sorption behaviors of phosphorus in sediment of the Three Gorges Reservoir. Environ Sci Pollut Res Int. 2017;24:17679-17687 pubmed publisher
    ..bacteria (OPB), were investigated in 27 sampling sites of five sections in the Three Gorges Reservoir (TGR) in December 2012...
  92. Gao L, Gao B, Peng W, Xu D, Yin S. Assessing potential release tendency of As, Mo and W in the tributary sediments of the Three Gorges Reservoir, China. Ecotoxicol Environ Saf. 2018;147:342-348 pubmed publisher
    As the largest man-made reservoir in China, the Three Gorges Reservoir (TGR) has significant influence on national drinking water safety. The geochemical behavior of trace elements at the sediment-water interface (SWI) is still unknown...