TWIST2

Summary

Gene Symbol: TWIST2
Description: twist family bHLH transcription factor 2
Alias: AMS, BBRSAY, DERMO1, FFDD3, SETLSS, bHLHa39, twist-related protein 2, class A basic helix-loop-helix protein 39, dermis-expressed protein 1, twist basic helix-loop-helix transcription factor 2, twist homolog 2, twist-related bHLH protein Dermo1
Species: human
Products:     TWIST2

Top Publications

  1. Li L, Cserjesi P, Olson E. Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis. Dev Biol. 1995;172:280-92 pubmed
    ..The expression pattern of Dermo-1 suggests that it functions as a regulator of gene expression in a subset of mesenchymal cell lineages including developing dermis. ..
  2. Tukel T, Sosic D, Al Gazali L, Erazo M, Casasnovas J, Franco H, et al. Homozygous nonsense mutations in TWIST2 cause Setleis syndrome. Am J Hum Genet. 2010;87:289-96 pubmed publisher
    ..Of the 29 candidate genes in this region, the bHLH transcription factor, TWIST2, was initially sequenced on the basis of its known involvement in murine facial development...
  3. Liang X, Zheng M, Jiang J, Zhu G, Yang J, Tang Y. Hypoxia-inducible factor-1 alpha, in association with TWIST2 and SNIP1, is a critical prognostic factor in patients with tongue squamous cell carcinoma. Oral Oncol. 2011;47:92-7 pubmed publisher
    ..The aim of our study was to elucidate the role of HIF-1? and HIF-2?, and EMT regulators TWIST2 and SMAD nuclear interacting protein-1 (SNIP1) in tongue squamous cell carcinoma (TSCC)...
  4. Zhou C, Liu J, Tang Y, Zhu G, Zheng M, Jiang J, et al. Coexpression of hypoxia-inducible factor-2?, TWIST2, and SIP1 may correlate with invasion and metastasis of salivary adenoid cystic carcinoma. J Oral Pathol Med. 2012;41:424-31 pubmed publisher
    ..The purpose of this study was to evaluate the relationship between hypoxia-inducible factor (HIF)-2?, TWIST2, and SIP1 expression and the invasion and metastasis in ACC of salivary gland.
  5. Mao Y, Zhang N, Xu J, Ding Z, Zong R, Liu Z. Significance of heterogeneous Twist2 expression in human breast cancers. PLoS ONE. 2012;7:e48178 pubmed publisher
    b>Twist2 (Dermo1) has been shown to mediate the epithelial-mesenchymal transition (EMT) to promote tumor invasion and even metastasis...
  6. Mao Y, Xu J, Li Z, Zhang N, Yin H, Liu Z. The role of nuclear ?-catenin accumulation in the Twist2-induced ovarian cancer EMT. PLoS ONE. 2013;8:e78200 pubmed publisher
    b>Twist2 has been shown to promote human tumor invasion as in breast cancer and cervical cancer. However, whether Twist2 promotes human ovarian cancer progression remains to be elucidated...
  7. Bialek P, Kern B, Yang X, Schrock M, Sosic D, Hong N, et al. A twist code determines the onset of osteoblast differentiation. Dev Cell. 2004;6:423-35 pubmed
    ..In vivo mutagenesis confirms the antiosteogenic function of the Twist box. Thus, relief of inhibition by Twist proteins is a mandatory event precluding osteoblast differentiation. ..
  8. Ansieau S, Bastid J, Doreau A, Morel A, Bouchet B, Thomas C, et al. Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell. 2008;14:79-89 pubmed publisher
    Twist1 and Twist2 are major regulators of embryogenesis. Twist1 has been shown to favor the metastatic dissemination of cancer cells through its ability to induce an epithelial-mesenchymal transition (EMT)...
  9. Mao Y, Toh H, Ding Z, Sun L, Hong L, Chen C, et al. Differential methylation of CpG islands within the dermo1 gene promoter in several cancer cell lines. Oncol Rep. 2011;25:107-11 pubmed
    ..Dermo1 (also called twist2) is a novel cancer-related gene which belongs to the basic helix-loop-helix (bHLH) transcription factor family...

More Information

Publications133 found, 100 shown here

  1. Gasparotto D, Polesel J, Marzotto A, Colladel R, Piccinin S, Modena P, et al. Overexpression of TWIST2 correlates with poor prognosis in head and neck squamous cell carcinomas. Oncotarget. 2011;2:1165-75 pubmed
    ..To this aim, a consecutive series of 69 HNSCC were analyzed for the expression of TWIST1, TWIST2, SNAI1, SNAI2, E-Cadherin, N-Cadherin and Vimentin...
  2. Yu H, Jin G, Liu K, Dong H, Yu H, Duan J, et al. Twist2 is a valuable prognostic biomarker for colorectal cancer. World J Gastroenterol. 2013;19:2404-11 pubmed publisher
    To investigate the significance of Twist2 for colorectal cancer (CRC). In this study, 93 CRC patients were included who received curative surgery in Eastern Hepatobiliary Surgery Hospital from January 1999 to December 2010...
  3. Wang T, Li Y, Wang W, Tuerhanjiang A, Wu Z, Yang R, et al. Twist2, the key Twist isoform related to prognosis, promotes invasion of cervical cancer by inducing epithelial-mesenchymal transition and blocking senescence. Hum Pathol. 2014;45:1839-46 pubmed publisher
    ..Oncogenic activation of Twist1 and Twist2 is essential for EMT and senescence; however, little is known about the specific contributions of Twist1 versus ..
  4. Fang X, Cai Y, Liu J, Wang Z, Wu Q, Zhang Z, et al. Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal. Oncogene. 2011;30:4707-20 pubmed publisher
    ..We report here that Twist2, a tissue-specific basic helix-loop-helix transcription factor, is overexpressed in human breast cancers and lymph ..
  5. Li Y, Wang W, Wang W, Yang R, Wang T, Su T, et al. Correlation of TWIST2 up-regulation and epithelial-mesenchymal transition during tumorigenesis and progression of cervical carcinoma. Gynecol Oncol. 2012;124:112-8 pubmed publisher
    ..This study investigated the clinic-pathological significance of twist homolog 2 (TWIST2), a basic helix-loop-helix transcription factor, and correlated TWIST2 and E-cadherin expression in ..
  6. Zhu Y, Zhang W, Wang P. Smoking and gender modify the effect of TWIST on patient survival in head and neck squamous carcinoma. Oncotarget. 2017;8:85816-85827 pubmed publisher
    ..Here, we study the prognostic significance of TWIST1 and TWIST2 in Head and Neck squamous cell carcinoma (HNSCC) as well as interactions of TWISTs with both gender and ..
  7. Goloviznina N, Kyba M. Twist of fate for skeletal muscle mesenchymal cells. Nat Cell Biol. 2017;19:153-154 pubmed publisher
    ..lineages with specific lineage-restricted progenitors? A provocative study now proposes that mesenchymal cells expressing the transcription factor Twist2 act as myogenic progenitors with selective type IIb fibre-differentiation potential.
  8. Lu M, Zhu W, Wang X, Tang J, Zhang K, Yu G, et al. ACOT12-Dependent Alteration of Acetyl-CoA Drives Hepatocellular Carcinoma Metastasis by Epigenetic Induction of Epithelial-Mesenchymal Transition. Cell Metab. 2019;29:886-900.e5 pubmed publisher
    ..acetylation in HCC cells and that down-regulation of ACOT12 promotes HCC metastasis by epigenetically inducing TWIST2 expression and the promotion of epithelial-mesenchymal transition...
  9. Sun R, Hedl M, Abraham C. Twist1 and Twist2 Induce Human Macrophage Memory upon Chronic Innate Receptor Treatment by HDAC-Mediated Deacetylation of Cytokine Promoters. J Immunol. 2019;: pubmed publisher
    ..Chronic NOD2 stimulation upregulated the transcription factors Twist1 and Twist2, which bound to the promoters of the histone deacetylases HDAC1 and HDAC3 and induced HDAC1 and ..
  10. Vellinga T, den Uil S, Rinkes I, Marvin D, Ponsioen B, Alvarez Varela A, et al. Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion. Oncogene. 2016;35:5263-5271 pubmed publisher
    ..tumors shows that the neoplastic cells in stromahigh tumors express specific EMT drivers (ZEB2, TWIST1, TWIST2) and that 98% of differentially expressed genes are strongly correlated with them...
  11. Hou Z, Wu Q, Sun X, Chen H, Li Y, Zhang Y, et al. Wnt/Fgf crosstalk is required for the specification of basal cells in the mouse trachea. Development. 2019;146: pubmed publisher
    ..leads to the loss of basal cells and cartilage, concomitant with reduced transcript levels of Fgf10 in Dermo1-Cre;Ctnnb1loxp/loxp mutants...
  12. Barreiro González A, Barranco González H, Aviñó Martínez J, López Blanco E, Gutiérrez Ontalvilla P, Evole Buselli M. Multidisciplinary eyelid reconstruction in Barber-Say syndrome: A case report. Arch Soc Esp Oftalmol. 2019;94:196-199 pubmed publisher
    Barber-Say syndrome is an unusual dysplasia caused by the mutation of the TWIST2 gene (2q37.3), which encodes a protein that acts at an epigenetic level...
  13. Nfonsam V, Nfonsam L, Chen D, Omesiete P, Cruz A, Runyan R, et al. COMP Gene Coexpresses With EMT Genes and Is Associated With Poor Survival in Colon Cancer Patients. J Surg Res. 2019;233:297-303 pubmed publisher
    ..Expression analysis revealed coexpression of COMP with the EMT markers CDH2, FN1, VIM, TWIST1, TWIST2, SNAI1, SNAI2, ZEB1, ZEB2, POSTN, MMP2, MMP9, and COL1A1...
  14. Zhao L, Liu S, Che X, Hou K, Ma Y, Li C, et al. Bufalin inhibits TGF-β-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-β receptors. Int J Mol Med. 2015;36:645-52 pubmed publisher
    ..Additionally, TGF‑β‑induced upregulation of Twist2 and zinc finger E‑box binding homeobox 2 (ZEB2), as well as the phosphorylation of Smad2 and Smad3 were ..
  15. Rojas Puentes L, Cardona A, Carranza H, Vargas C, JARAMILLO L, Zea D, et al. Epithelial-mesenchymal transition, proliferation, and angiogenesis in locally advanced cervical cancer treated with chemoradiotherapy. Cancer Med. 2016;5:1989-99 pubmed publisher
    ..002), epidermal growth factor receptor (EGFR) (P = 0.001), and TWIST2 (P = 0.001) expression levels, as well as a tumor size <6 cm (P = 0.02), influenced OS...
  16. Lu K, Dong J, Fan W. Twist1/2 activates MMP2 expression via binding to its promoter in colorectal cancer. Eur Rev Med Pharmacol Sci. 2018;22:8210-8219 pubmed publisher
    This study aimed to characterize the effect of Twist2 on epithelial-to-mesenchymal transition (EMT) and the invasive potential of colorectal cancer (CRC) cells and to explore the mechanisms underlying the regulative effect of Twist1 and ..
  17. Scott C, Wong E, Joo J, Dugué P, Jung C, O Callaghan N, et al. Genome-wide DNA methylation assessment of 'BRCA1-like' early-onset breast cancer: Data from the Australian Breast Cancer Family Registry. Exp Mol Pathol. 2018;105:404-410 pubmed publisher
    ..across 17 consecutive marks in the BRCA1 promoter region and decreased at several other genomic regions (including TWIST2 and CTBP1) for 7 women (23%) diagnosed with BRCA1-like breast cancer compared with women in the other groups...
  18. Slavotinek A, Mehrotra P, Nazarenko I, Tang P, Lao R, Cameron D, et al. Focal facial dermal dysplasia, type IV, is caused by mutations in CYP26C1. Hum Mol Genet. 2013;22:696-703 pubmed publisher
    ..Sequencing of four additional, unrelated Type IV FFDD patients and eight Type II or III TWIST2-negative FFDD patients revealed that three of the Type IV patients were homozygous for the duplication, whereas ..
  19. Snowball J, Ambalavanan M, Cornett B, Lang R, Whitsett J, Sinner D. Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall. Dev Biol. 2015;401:264-75 pubmed publisher
    ..Wls(f/f);Dermo1(Cre/+) embryos died during mid-gestation. At E13...
  20. Topczewska J, Shoela R, Tomaszewski J, Mirmira R, Gosain A. The Morphogenesis of Cranial Sutures in Zebrafish. PLoS ONE. 2016;11:e0165775 pubmed publisher
    ..RNA in situ hybridization for col1a1a, col2a1a, col10a1, bglap/osteocalcin, fgfr1a, fgfr1b, fgfr2, fgfr3, foxq1, twist2, twist3, runx2a, runx2b, sp7/osterix, and spp1/ osteopontin, indicating that the expression of genes involved in ..
  21. Zhang H, Tao J, Sheng L, Hu X, Rong R, Xu M, et al. RETRACTED: Twist2 promotes kidney cancer cell proliferation and invasion via regulating ITGA6 and CD44 expression in the ECM-Receptor-Interaction pathway. Biomed Pharmacother. 2016;81:453-9 pubmed publisher
    b>Twist2 is a member of the basic helix-loop-helix (bHLH) family and plays a critical role in tumorigenesis...
  22. Yang J, Zhu D, Zhou X, Yin N, Zhang Y, Zhang Z, et al. HIF-2α promotes the formation of vasculogenic mimicry in pancreatic cancer by regulating the binding of Twist1 to the VE-cadherin promoter. Oncotarget. 2017;8:47801-47815 pubmed publisher
    ..expression and VM by immunohistochemistry in 70 pancreatic cancer patients as well as the role of Twist1and Twist2 in HIF-2α-induced VM in vitro and in vivo...
  23. Tamura M, Amano T, Shiroishi T. The Hand2 gene dosage effect in developmental defects and human congenital disorders. Curr Top Dev Biol. 2014;110:129-52 pubmed publisher
    ..Mutations of the TWIST1 and TWIST2 genes are involved in human diseases...
  24. Zhang H, Tao J, Sheng L, Hu X, Rong R, Xu M, et al. Twist2 promotes kidney cancer cell proliferation and invasion by regulating ITGA6 and CD44 expression in the ECM-receptor interaction pathway. Onco Targets Ther. 2016;9:1801-12 pubmed publisher
    b>Twist2 is a member of the basic helix-loop-helix (bHLH) family and plays a critical role in tumorigenesis...
  25. Matsunobu T, Torigoe K, Ishikawa M, de Vega S, Kulkarni A, Iwamoto Y, et al. Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. Dev Biol. 2009;332:325-38 pubmed publisher
    ..with a conditional knockout of the TGF-beta type I receptor ALK5 (ALK5(CKO)) in skeletal progenitor cells using Dermo1-Cre mice. ALK5(CKO) mice had short and wide long bones, reduced bone collars, and trabecular bones...
  26. Qin X, Jiang Q, Matsuo Y, Kawane T, Komori H, Moriishi T, et al. Cbfb regulates bone development by stabilizing Runx family proteins. J Bone Miner Res. 2015;30:706-14 pubmed publisher
    ..Cbfb in mesenchymal cells giving rise to both chondrocyte and osteoblast lineages by mating Cbfb(fl/fl) mice with Dermo1 Cre knock-in mice...
  27. Cong Q, Jia H, Biswas S, Li P, Qiu S, Deng Q, et al. p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions. Stem Cell Reports. 2016;6:566-578 pubmed publisher
    ..Ablation of p38α in BM-MSCs positive for Dermo1, a later BM-MSC marker, only affected osteogenic differentiation...
  28. Cornett B, Snowball J, Varisco B, Lang R, Whitsett J, Sinner D. Wntless is required for peripheral lung differentiation and pulmonary vascular development. Dev Biol. 2013;379:38-52 pubmed publisher
    ..We generated conditional Wls mutant mice utilizing Shh-Cre and Dermo1-Cre mice to delete Wls in the embryonic respiratory epithelium and mesenchyme, respectively...
  29. Watson K, Jones R, Bruce A, Moorehead R. The miR-200b/200a/429 cluster prevents metastasis and induces dormancy in a murine claudin-low mammary tumor cell line. Exp Cell Res. 2018;369:17-26 pubmed publisher
    ..of the miR-200b/200a/429 cluster in RJ423 cells significantly suppressed the expression of Vim, Snai1, Twist1, Twist2 and Zeb1, reverted RJ423 cells to a more epithelial morphology and significantly inhibited proliferation in vitro...
  30. Min Y, Jaichander P, Sanchez Ortiz E, Bezprozvannaya S, Malladi V, Cui M, et al. Identification of a multipotent Twist2-expressing cell population in the adult heart. Proc Natl Acad Sci U S A. 2018;115:E8430-E8439 pubmed publisher
    ..Through lineage tracing of Twist2 (Tw2)-expressing cells with tamoxifen-inducible Tw2-CreERT2 and tdTomato (tdTO) reporter mice, we discovered a ..
  31. Wang W, Strecker S, Liu Y, Wang L, Assanah F, Smith S, et al. Connective Tissue Growth Factor reporter mice label a subpopulation of mesenchymal progenitor cells that reside in the trabecular bone region. Bone. 2015;71:76-88 pubmed publisher
    ..culture, CTGF reporter expression and endogenous CTGF expression marked the same cell types as those labeled using Twist2-Cre and Osterix-Cre fate mapping approaches, which previously had been shown to identify mesenchymal progenitors ..
  32. Grimston S, Watkins M, Brodt M, Silva M, Civitelli R. Enhanced periosteal and endocortical responses to axial tibial compression loading in conditional connexin43 deficient mice. PLoS ONE. 2012;7:e44222 pubmed publisher
    ..at both endocortical and periosteal surfaces in 2-month-old mice with conditional Gja1 ablation driven by the Dermo1 promoter (cKO)...
  33. Al Khalaf H, Aboussekhra A. MicroRNA-141 and microRNA-146b-5p inhibit the prometastatic mesenchymal characteristics through the RNA-binding protein AUF1 targeting the transcription factor ZEB1 and the protein kinase AKT. J Biol Chem. 2014;289:31433-47 pubmed publisher
    ..regulate the epithelial markers (E-cadherin and Epcam) and repress the mesenchymal markers (N-cadherin, Vimentin, Twist2, and ZEB1)...
  34. Oh J, Lee C, Oh S, Jeon S, Choi J, Hwang S, et al. Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes. Cell Death Differ. 2016;23:1804-1814 pubmed publisher
    ..We found that the expression of Twist2 is differentially regulated in positively and negatively selected thymocytes...
  35. Jean Marçais N, Decamp M, Gérard M, Ribault V, Andrieux J, Kottler M, et al. The first familial case of inherited 2q37.3 interstitial deletion with isolated skeletal abnormalities including brachydactyly type E and short stature. Am J Med Genet A. 2015;167A:185-9 pubmed publisher
    ..This paper reports the first familial case of 2q37.3 interstitial deletion affecting two genes, HDAC4 and TWIST2. Patients presented with BDE and short stature without intellectual disability, showing that haploinsufficiency of ..
  36. Droscha C, Diegel C, Ethen N, Burgers T, McDonald M, Maupin K, et al. Osteoblast-specific deletion of Hrpt2/Cdc73 results in high bone mass and increased bone turnover. Bone. 2017;98:68-78 pubmed publisher
    ..Homozygous deletion of Cdc73 via the Dermo1-Cre driver resulted in embryos which lacked mesenchymal organ development of internal organs, including the heart ..
  37. Bowers L, Rossi E, McDonell S, Doerstling S, Khatib S, Lineberger C, et al. Leptin Signaling Mediates Obesity-Associated CSC Enrichment and EMT in Preclinical TNBC Models. Mol Cancer Res. 2018;16:869-879 pubmed publisher
    ..mice increased cell viability, migration, invasion, and CSC- and EMT-related gene expression, including Foxc2, Twist2, Vim, Akt3, and Sox2 In E-Wnt cells, knockdown of leptin receptor ablated these procancer effects ..
  38. Yorgan T, Heckt T, Rendenbach C, Helmis C, Seitz S, Streichert T, et al. Immediate effects of retinoic acid on gene expression in primary murine osteoblasts. J Bone Miner Metab. 2016;34:161-70 pubmed publisher
    ..e. Rara, Crabp2) or skeletal remodeling (i.e. Twist2, Tnfsf11)...
  39. Meier D, Lopez M, Franken P, Fontana A. Twist1 Is a TNF-Inducible Inhibitor of Clock Mediated Activation of Period Genes. PLoS ONE. 2015;10:e0137229 pubmed publisher
    ..In the present study we have assessed the two E-box binding transcriptional regulators Twist1 and Twist2 for their role in cytokine induced inhibition of clock genes...
  40. Tiwari A, Loughner C, Swamynathan S, Swamynathan S. KLF4 Plays an Essential Role in Corneal Epithelial Homeostasis by Promoting Epithelial Cell Fate and Suppressing Epithelial-Mesenchymal Transition. Invest Ophthalmol Vis Sci. 2017;58:2785-2795 pubmed publisher
    ..markers vimentin, ?-catenin, survivin, and cyclin-D1 and the EMT transcription factors Snail, Slug, Twist1, Twist2, Zeb1, and Zeb2 were up-regulated in the Klf4?/?CE corneas...
  41. Lee B, Kasparis C, Chen B, Mei H, Edelmann L, Moss C, et al. Setleis syndrome due to inheritance of the 1p36.22p36.21 duplication: evidence for lack of penetrance. J Hum Genet. 2015;60:717-22 pubmed publisher
    ..The syndrome results from recessive mutations in the TWIST2 gene, encoding a basic helix-loop-helix transcription factor or de novo genomic duplication or triplication, which ..
  42. Hu Y, Hu L, Gong D, Lu H, Xuan Y, Wang R, et al. Genome-wide DNA methylation analysis in jejunum of Sus scrofa with intrauterine growth restriction. Mol Genet Genomics. 2018;293:807-818 pubmed publisher
    ..was used for validations of 19 genes with epigenetic abnormality, confirming three genes (AIFM1, MTMR1, and TWIST2) in extra samples...
  43. Shekaran A, Shoemaker J, Kavanaugh T, Lin A, LaPlaca M, Fan Y, et al. The effect of conditional inactivation of beta 1 integrins using twist 2 Cre, Osterix Cre and osteocalcin Cre lines on skeletal phenotype. Bone. 2014;68:131-41 pubmed publisher
    ..To further investigate the role of β1 integrins on skeletal phenotype, we used the Twist2-Cre, Osterix-Cre and osteocalcin-Cre lines to generate conditional β1 integrin deletions, where Cre is ..
  44. Datta T, Rajput S, Wee G, Lee K, Folger J, Smith G. Requirement of the transcription factor USF1 in bovine oocyte and early embryonic development. Reproduction. 2015;149:203-12 pubmed publisher
    ..A similar (USF2) yet unique (TWIST2) expression pattern during oocyte and early embryonic development for related E-box binding transcription factors ..
  45. Que L, Zhao D, Tang X, Liu J, Zhang X, Zhan Y, et al. Effects of lentivirus-mediated shRNA targeting integrin-linked kinase on oral squamous cell carcinoma in vitro and in vivo. Oncol Rep. 2016;35:89-98 pubmed publisher
    ..Additionally, ILK shRNA inhibited EMT by impairing the expression of Snail, Slug and Twist2 and enhacning E-cadherin expression...
  46. Gong F, Zhao F, Gan X. Celastrol protects TGF-?1-induced endothelial-mesenchymal transition. J Huazhong Univ Sci Technolog Med Sci. 2017;37:185-190 pubmed publisher
    ..pathway, which was also confirmed by the inhibition of its downstream transcription factor snail1, twist1, twist2, ZEB1 and ZEB2...
  47. Rothammer S, Kunz E, Krebs S, Bitzer F, Hauser A, Zinovieva N, et al. Remapping of the belted phenotype in cattle on BTA3 identifies a multiplication event as the candidate causal mutation. Genet Sel Evol. 2018;50:36 pubmed publisher
    ..The closest gene to the candidate causal mutation (16 kb distal) is TWIST2. Based on our findings and those of a previously published study that identified the same multiplication event, a ..
  48. Boggs K, Venkatesan N, Mederacke I, Komatsu Y, Stice S, Schwabe R, et al. Contribution of Underlying Connective Tissue Cells to Taste Buds in Mouse Tongue and Soft Palate. PLoS ONE. 2016;11:e0146475 pubmed publisher
    ..connective tissue cells: (1) P0-Cre/R26-tdTomato (RFP) to label NC, NC derived Schwann cells and derivatives; (2) Dermo1-Cre/RFP to label mesenchymal cells and derivatives; and (3) Vimentin-CreER/mGFP to label Vimentin-expressing CT ..
  49. Wu Y, Chung I, Wong W, Masamune A, Sim M, Looi C. Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells. Biochim Biophys Acta Gen Subj. 2017;1861:296-306 pubmed publisher
    ..and mesenchymal-like gene expression of N-cadherin, vimentin, fibronectin, collagen I, Sip1, Snail, Slug, and Twist2. Inhibition of JAK/Stat3 signaling induced by IL-6 repressed EMT and Nrf2 gene expression...
  50. Chan S, Zhang Y, Shao A, Avdulov S, Herrera J, Aboudehen K, et al. Mechanism of Fibrosis in HNF1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease. J Am Soc Nephrol. 2018;29:2493-2509 pubmed publisher
    ..These cells also showed upregulation of fibrosis and EMT pathways, including upregulation of Twist2, Snail1, Snail2, and Zeb2, which are key EMT transcription factors...
  51. Yu K, Karuppaiah K, Ornitz D. Mesenchymal fibroblast growth factor receptor signaling regulates palatal shelf elevation during secondary palate formation. Dev Dyn. 2015;244:1427-38 pubmed publisher
    ..FGFR) signaling during palate development by conditional inactivation of Fgfrs using a mesenchyme-specific Dermo1-Cre driver...
  52. Liu N, Garry G, Li S, Bezprozvannaya S, Sanchez Ortiz E, Chen B, et al. A Twist2-dependent progenitor cell contributes to adult skeletal muscle. Nat Cell Biol. 2017;19:202-213 pubmed publisher
    ..By lineage tracing of progenitor cells expressing the Twist2 (Tw2) transcription factor in mice, we discovered a myogenic lineage that resides outside the basal lamina of ..
  53. Higashihori N, Lehnertz B, Sampaio A, Underhill T, Rossi F, Richman J. Methyltransferase G9A Regulates Osteogenesis via Twist Gene Repression. J Dent Res. 2017;96:1136-1144 pubmed publisher
    ..Chromatin immunoprecipitation analysis of primary osteogenic mesenchyme from calvaria revealed that Twist1 and Twist2 regulatory regions contain the repressive H3K9me2 marks catalyzed by G9A, which are removed when BIX-01294 is ..
  54. Volorio S, Simon G, Repetto M, Cucciardi M, Banfi S, Borsani G, et al. Sequencing analysis of forty-eight human image cDNA clones similar to Drosophila mutant protein. DNA Seq. 1998;9:307-15 pubmed
    ..We think the value of this full-length sequencing project is an enrichment of the sequence database information that is currently available to the human genome community. ..
  55. Sailer M, Sarvepalli D, Bregere C, Fisch U, Guentchev M, Weller M, et al. An Enzyme- and Serum-free Neural Stem Cell Culture Model for EMT Investigation Suited for Drug Discovery. J Vis Exp. 2016;: pubmed publisher
    ..Using this system, interactions between FGF-, BMP- and TGF?-signaling involving Zeb1, Zeb2, and Twist2 were observed where TGF?-activation significantly enhanced cell migration, suggesting a synergistic BMP-/TGF?-..
  56. Boregowda S, Krishnappa V, Strivelli J, Haga C, Booker C, Phinney D. Basal p53 expression is indispensable for mesenchymal stem cell integrity. Cell Death Differ. 2018;25:677-690 pubmed publisher
    ..Using knockout mice and gene silencing we show that p53 inactivation downregulates expression of TWIST2, which normally restrains cellular differentiation to maintain wild-type MSCs in a multipotent state, depletes ..
  57. Ustiyan V, Bolte C, Zhang Y, Han L, Xu Y, Yutzey K, et al. FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme. Dev Biol. 2018;443:50-63 pubmed publisher
    ..In the present study, we generated mesenchyme-specific Foxf1 knockout mice (Dermo1-Cre Foxf1-/-) and demonstrated that FOXF1 is required for development of respiratory, cardiovascular ..
  58. Loriot C, Domingues M, Berger A, Menara M, Ruel M, Morin A, et al. Deciphering the molecular basis of invasiveness in Sdhb-deficient cells. Oncotarget. 2015;6:32955-65 pubmed publisher
    ..This phenotype is associated with the modulation of Twist1, Twist2, Tcf3, Snai1, N-cadherin or Krt19 expression, reflecting an EMT-like reprogramming of cells...
  59. Perrin Schmitt F, Bolcato Bellemin A, Bourgeois P, Stoetzel C, Danse J. The locations of the H-twist and H-dermo-1 genes are distinct on the human genome. Biochim Biophys Acta. 1997;1360:1-2 pubmed
  60. Debruyne D, Bhatnagar N, Sharma B, Luther W, Moore N, Cheung N, et al. ALK inhibitor resistance in ALK(F1174L)-driven neuroblastoma is associated with AXL activation and induction of EMT. Oncogene. 2016;35:3681-91 pubmed publisher
    ..Although ectopic expression of AXL and TWIST2 individually in TAE684-sensitive parental cells led to the elevated expression of mesenchymal markers and invasive ..
  61. Zhong Z, Zahatnansky J, Snider J, Van Wieren E, Diegel C, Williams B. Wntless spatially regulates bone development through β-catenin-dependent and independent mechanisms. Dev Dyn. 2015;244:1347-55 pubmed publisher
    ..mice with strains expressing cre recombinase behind the following promoters: Osteocalcin, Collagen 2a1, or Dermo1. Ex vivo µCT and whole-mount skeletal staining were performed to examine skeletal mineralization...
  62. Awasthi Mishra N, Drogemuller C, Jagannathan V, Keller I, Wüthrich D, Bruggmann R, et al. A structural variant in the 5'-flanking region of the TWIST2 gene affects melanocyte development in belted cattle. PLoS ONE. 2017;12:e0180170 pubmed publisher
    ..CNV) involving the quadruplication of a 6 kb non-coding sequence located approximately 16 kb upstream of the TWIST2 gene...
  63. Kim D, Seo S, Zeng M, Kim W, Kamada N, Inohara N, et al. Mesenchymal Cell-Specific MyD88 Signaling Promotes Systemic Dissemination of Salmonella Typhimurium via Inflammatory Monocytes. J Immunol. 2017;199:1362-1371 pubmed publisher
    ..Surprisingly, we found that Dermo1-Cre;Myd88fl/fl mice with mesenchymal cell-specific deficiency of MyD88 were less susceptible to ..
  64. Mushtaq M, Jensen L, Davidsson S, Grygoruk O, Andrén O, Kashuba V, et al. The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells. Sci Rep. 2018;8:2268 pubmed publisher
    ..The mRNA expression of TWIST2, encoding one of transcription factors that induce EMT upon CXCR4 increase, positively correlated with the S18-2 ..
  65. Yang X, Ma G, Feng N, Yu D, Wu Y, Li C. Twist2 and CD24 expression alters renal microenvironment in obesity associated kidney cancer. Eur Rev Med Pharmacol Sci. 2018;22:358-364 pubmed publisher
    ..The expression of Twist2 and CD24 was assessed using Immunohistology and Western Blotting in a different time interval of kidney cancer...
  66. Ulrich C, Rolauffs B, Abele H, Bonin M, Nieselt K, Hart M, et al. Low osteogenic differentiation potential of placenta-derived mesenchymal stromal cells correlates with low expression of the transcription factors Runx2 and Twist2. Stem Cells Dev. 2013;22:2859-72 pubmed publisher
    ..04), and WISP2 (P<0.05), were expressed at significantly lower levels in pMSC, but twist-related protein 2 (Twist2) (P<0.0002) was expressed at significantly higher levels...
  67. Yamazaki J, Jelinek J, Hisamoto S, Tsukamoto A, Inaba M. Dynamic changes in DNA methylation patterns in canine lymphoma cell lines demonstrated by genome-wide quantitative DNA methylation analysis. Vet J. 2018;231:48-54 pubmed publisher
    ..These hypermethylated CpG sites are located at promoter regions of hundreds of genes, such as TWIST2 and TLX3...
  68. Liu Z, Chen O, Zheng M, Wang L, Zhou Y, Yin C, et al. Re-patterning of H3K27me3, H3K4me3 and DNA methylation during fibroblast conversion into induced cardiomyocytes. Stem Cell Res. 2016;16:507-18 pubmed publisher
    ..factors revealed a similarly late deposition of H3K27me3 and decreased mRNA expression of Sox9, Twist1 and Twist2, three important players in epithelial-mesenchymal transition...
  69. Kaneko T, Freeha K, Wu X, Mogi M, Uji S, Yokoi H, et al. Role of notochord cells and sclerotome-derived cells in vertebral column development in fugu, Takifugu rubripes: histological and gene expression analyses. Cell Tissue Res. 2016;366:37-49 pubmed publisher
    ..Synthesis of the matrix by the basal cells was ascertained by an in vitro test. Expression of twist2 indicates that this connective tissue is descended from the embryonic sclerotome...
  70. Meng T, Huang Y, Wang S, Zhang H, Dechow P, Wang X, et al. Twist1 Is Essential for Tooth Morphogenesis and Odontoblast Differentiation. J Biol Chem. 2015;290:29593-602 pubmed publisher
    ..To better delineate its roles in tooth development, we generated Twist1 conditional knockout embryos (Twist2(Cre) (/+);Twist1(fl/fl)) by breeding Twist1 floxed mice (Twist1(fl/fl)) with Twist2-Cre recombinase knockin mice (..
  71. Grunz Borgmann E, Nichols L, Wang X, Parrish A. Twist2 Is Upregulated in Early Stages of Repair Following Acute Kidney Injury. Int J Mol Sci. 2017;18: pubmed publisher
    ..To begin to elucidate mechanism(s) underlying dysrepair in the aging kidney, we examined the expression of Twist2, a helix-loop-helix transcription factor that may mediate renal fibrosis...
  72. Zheng S, Hedl M, Abraham C. Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators. J Immunol. 2015;195:217-26 pubmed publisher
    ..The role for the transcriptional repressors Twist1 and Twist2 in regulating PRR-induced cytokine outcomes is poorly understood and has not been reported for NOD2...
  73. Hatta M, Naganuma K, Kato K, Yamazaki J. 3-Deazaneplanocin A suppresses aggressive phenotype-related gene expression in an oral squamous cell carcinoma cell line. Biochem Biophys Res Commun. 2015;468:269-73 pubmed publisher
    ..Finally, quantitative RT-PCR analysis demonstrated that genes involved in the aggressive phenotypes (TWIST2, EGFR, ACTA2, TGFB1, WNT5B, and APLIN) were down-regulated, whereas epithelial phenotype genes (CDH1, CLDN4, IVL, ..
  74. Chen H, Wei Z, Sun J, Bhattacharya A, Savage D, Serda R, et al. A recellularized human colon model identifies cancer driver genes. Nat Biotechnol. 2016;34:845-51 pubmed publisher
    ..We identified 38 candidate invasion-driver genes, 17 of which, including TCF7L2, TWIST2, MSH2, DCC, EPHB1 and EPHB2 have been previously implicated in colorectal cancer progression...
  75. Wu X, Li X, Fu Q, Cao Q, Chen X, Wang M, et al. AKR1B1 promotes basal-like breast cancer progression by a positive feedback loop that activates the EMT program. J Exp Med. 2017;214:1065-1079 pubmed publisher
    ..Mechanistically, Twist2 transcriptionally induces AKR1B1 expression, leading to nuclear factor ?B (NF-?B) activation...
  76. Nishioka M, Venkatesan N, Dessalle K, Mogas A, Kyoh S, Lin T, et al. Fibroblast-epithelial cell interactions drive epithelial-mesenchymal transition differently in cells from normal and COPD patients. Respir Res. 2015;16:72 pubmed publisher
    ..CM from NHLF significantly induced Twist1 and Twist2 expression in NHBE cells and increased Snai2 (Slug) expression in DHBE cells...
  77. Anelli V, Villefranc J, Chhangawala S, Martinez McFaline R, Riva E, Nguyen A, et al. Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression. elife. 2017;6: pubmed publisher
    ..Gene expression studies nominated TWIST2 as a key effector downstream of BRAF...
  78. Koh Y, Park I, Sun C, Lee S, Yun H, Park C, et al. Detection of a Distinctive Genomic Signature in Rhabdoid Glioblastoma, A Rare Disease Entity Identified by Whole Exome Sequencing and Whole Transcriptome Sequencing. Transl Oncol. 2015;8:279-87 pubmed publisher
    ..Fusion gene analysis showed 14 candidate genes that may be functionally involved in R-GBM, including TWIST2, and UPK3BL. The BRAF V600E mutation, CDKN2A/2B deletion, and EGFR/MET copy number gain were observed...
  79. Koh H, Lee C, Lee K, Park E, Seong R, Hong S, et al. Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T-cells. Mol Cells. 2009;28:553-8 pubmed publisher
    ..Here, we show that CD7 expression was downregulated by Twist2 in Jurkat cells, a human acute T-cell lymphoma cell line, and in EL4 cells, a mature murine T-cell lymphoma cell ..
  80. Thathia S, Ferguson S, Gautrey H, van Otterdijk S, Hili M, Rand V, et al. Epigenetic inactivation of TWIST2 in acute lymphoblastic leukemia modulates proliferation, cell survival and chemosensitivity. Haematologica. 2012;97:371-8 pubmed publisher
    Altered regulation of many transcription factors has been shown to be important in the development of leukemia. TWIST2 modulates the activity of a number of important transcription factors and is known to be a regulator of hematopoietic ..
  81. Van Den Bosch M, Palsson McDermott E, Johnson D, O Neill L. LPS induces the degradation of programmed cell death protein 4 (PDCD4) to release Twist2, activating c-Maf transcription to promote interleukin-10 production. J Biol Chem. 2014;289:22980-90 pubmed publisher
    ..PDCD4 and the transcription factor Twist2 were shown to form a complex in untreated cells...
  82. Ren S, Luo Y, Chen H, Warburton D, Lam H, Wang L, et al. Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization. Am J Pathol. 2016;186:3261-3272 pubmed publisher
    ..We deleted Tsc2 specifically in mesoderm-derived mesenchymal cells of multiple organs in mice using the Dermo1-Cre driver...
  83. Ho U, Wainwright B. Patched1 patterns Fibroblast growth factor 10 and Forkhead box F1 expression during pulmonary branch formation. Mech Dev. 2017;147:37-48 pubmed publisher
    ..The Hedgehog receptor Patched1 (Ptch1) was conditionally inactivated in the lung mesenchyme by Dermo1-Cre in vivo or using a recombinant Cre recombinase protein (HNCre) in lung cultures resulting in cell autonomous ..
  84. Galván J, Helbling M, Koelzer V, Tschan M, Berger M, Hädrich M, et al. TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer. Oncotarget. 2015;6:874-85 pubmed
    ..EMT) characterized predominantly by loss of E-cadherin and up-regulation of E-cadherin repressors like TWIST1 and TWIST2. Here we investigate a possible epigenetic link between TWIST proteins and the tumor budding phenotype...
  85. Chengxiao Z, Ze Y. Biological function and molecular mechanism of Twist2. Yi Chuan. 2015;37:17-24 pubmed publisher
    b>Twist2, one of the basic helix-loop-helix protein (bHLH) family members, is responsible for the transcriptional regulation in mesenchymal cell lineages during its development...
  86. He Y, Sun X, Wang L, Mishina Y, Guan J, Liu F. Male germline recombination of a conditional allele by the widely used Dermo1-cre (Twist2-cre) transgene. Genesis. 2017;55: pubmed publisher
    ..Dermo1-Cre (Twist2-Cre) has been widely used to target skeletal lineage cells as well as other mesoderm-derived cells...
  87. Nagashima K, Sawa S, Nitta T, Prados A, Koliaraki V, Kollias G, et al. Targeted deletion of RANKL in M cell inducer cells by the Col6a1-Cre driver. Biochem Biophys Res Commun. 2017;493:437-443 pubmed publisher
    ..In the previous study, the Twist2-Cre driver was utilized for gene deletion in mesenchymal cells including MCi cells...
  88. Plasilova M, Chattopadhyay C, Ghosh A, Wenzel F, Demougin P, Noppen C, et al. Discordant gene expression signatures and related phenotypic differences in lamin A- and A/C-related Hutchinson-Gilford progeria syndrome (HGPS). PLoS ONE. 2011;6:e21433 pubmed publisher
    ..7% (15/90) discordant transcriptional changes. Among the concordant ones we observed down-regulation of TWIST2, whose inactivation in mice and humans leads to loss of subcutaneous fat and dermal appendages, and loss of ..
  89. Cervantes Barragán D, Villarroel C, Medrano Hernández A, Duran McKinster C, Bosch Canto V, Del Castillo V, et al. Setleis syndrome in Mexican-Nahua sibs due to a homozygous TWIST2 frameshift mutation and partial expression in heterozygotes: review of the focal facial dermal dysplasias and subtype reclassification. J Med Genet. 2011;48:716-20 pubmed publisher
    ..Recently, different homozygous TWIST2 nonsense mutations were reported in unrelated Setleis syndrome (FFDD Type III) patients from consanguineous ..
  90. Marchegiani S, Davis T, Tessadori F, van Haaften G, Brancati F, Hoischen A, et al. Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes. Am J Hum Genet. 2015;97:99-110 pubmed publisher
    ..We identified a recurrent de novo mutation in TWIST2 in seven independent AMS-affected families, as well as another recurrent de novo mutation affecting the same amino ..
  91. Han M, Xu W. EMP3 is induced by TWIST1/2 and regulates epithelial-to-mesenchymal transition of gastric cancer cells. Tumour Biol. 2017;39:1010428317718404 pubmed publisher
    ..Results showed that TWIST1 and TWIST2 are usually co-upregulated in patients with primary gastric cancer...
  92. Iribar H, Pérez López V, Etxaniz U, Gutiérrez Rivera A, Izeta A. Schwann Cells in the Ventral Dermis Do Not Derive from Myf5-Expressing Precursors. Stem Cell Reports. 2017;9:1477-1487 pubmed publisher
    ..Precursor cells traced by Myf5 and Twist2 (Dermo1) promoter activation (i.e...