TWEAK

Summary

Gene Symbol: TWEAK
Description: TNF superfamily member 12
Alias: APO3L, DR3LG, TNLG4A, TWEAK, tumor necrosis factor ligand superfamily member 12, APO3 ligand, APO3/DR3 ligand, TNF-related WEAK inducer of apoptosis, tumor necrosis factor (ligand) superfamily, member 12, tumor necrosis factor ligand 4A, tumor necrosis factor superfamily member 12
Species: human
Products:     TWEAK

Top Publications

  1. Wiley S, Winkles J. TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. Cytokine Growth Factor Rev. 2003;14:241-9 pubmed
    The cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK) was initially described as a member of the tumor necrosis factor (TNF) superfamily in 1997...
  2. Park M, Chung S, Jung S, Park Y, Lee S. Relationship of serum TWEAK level to cytokine level, disease activity, and response to anti-TNF treatment in patients with rheumatoid arthritis. Scand J Rheumatol. 2008;37:173-8 pubmed publisher
    To determine the serum concentration of tumour necrosis factor (TNF)-related weak inducer of apoptosis (TWEAK) in patients with rheumatoid arthritis (RA) and to investigate the relationship between TWEAK level and disease activity, ..
  3. Ho D, Vu H, Brown S, Donohue P, Hanscom H, Winkles J. Soluble tumor necrosis factor-like weak inducer of apoptosis overexpression in HEK293 cells promotes tumor growth and angiogenesis in athymic nude mice. Cancer Res. 2004;64:8968-72 pubmed
    Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily of structurally related cytokines. TWEAK acts on responsive cells via binding to a cell surface receptor named Fn14...
  4. Chacon M, Richart C, Gomez J, Megia A, Vilarrasa N, Fernandez Real J, et al. Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue. Relationship with other inflammatory cytokines in obesity. Cytokine. 2006;33:129-37 pubmed
    b>TWEAK, a cytokine of the TNF family, has been found to be expressed under different inflammatory conditions but no data is available concerning the expression of this cytokine and its receptor (Fn14) in human obesity...
  5. Jin L, Nakao A, Nakayama M, Yamaguchi N, Kojima Y, Nakano N, et al. Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes. J Invest Dermatol. 2004;122:1175-9 pubmed
    TNF-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor (TNF) family, is a multifunctional cytokine that regulate cellular proliferation, angiogenesis, inflammation, and apoptosis...
  6. Brown S, Ghosh A, Winkles J. Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway. J Biol Chem. 2010;285:17432-41 pubmed publisher
    ..b>TWEAK (TNF-like weak inducer of apoptosis), a member of the TNF family, is a multifunctional cytokine that acts via ..
  7. Vázquez Carballo A, Ceperuelo Mallafré V, Chacon M, Maymó Masip E, Lorenzo M, Porras A, et al. TWEAK prevents TNF-?-induced insulin resistance through PP2A activation in human adipocytes. Am J Physiol Endocrinol Metab. 2013;305:E101-12 pubmed publisher
    ..b>TWEAK is a relatively new member of the TNF cytokine superfamily, which can exist as full length membrane-associated (..
  8. Pelekanou V, Notas G, Theodoropoulou K, Kampa M, Takos D, Alexaki V, et al. Detection of the TNFSF members BAFF, APRIL, TWEAK and their receptors in normal kidney and renal cell carcinomas. Anal Cell Pathol (Amst). 2011;34:49-60 pubmed publisher
    ..Here, we assayed the TNFSF members APRIL, BAFF, TWEAK and their receptors (BCMA, TACI, BAFFR, Fn14) in 86 conventional type clear cell RCC, using immunohistochemistry ..
  9. Gao H, Campbell S, Burkly L, Jakubowski A, Jarchum I, Banas B, et al. TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells. Cytokine. 2009;46:24-35 pubmed publisher
    ..b>TWEAK, a member of the TNF-ligand superfamily, is markedly increased in urine from patients with active lupus nephritis, ..

More Information

Publications66

  1. Chicheportiche Y, Bourdon P, Xu H, Hsu Y, Scott H, Hession C, et al. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J Biol Chem. 1997;272:32401-10 pubmed
    ..Here we describe a new ligand in this family, designated TWEAK. The mouse and human versions of this protein are unusually conserved with 93% amino acid identity in the receptor ..
  2. Munoz Garcia B, Madrigal Matute J, Moreno J, Martin Ventura J, Lopez Franco O, Sastre C, et al. TWEAK-Fn14 interaction enhances plasminogen activator inhibitor 1 and tissue factor expression in atherosclerotic plaques and in cultured vascular smooth muscle cells. Cardiovasc Res. 2011;89:225-33 pubmed publisher
    ..Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumour necrosis factor superfamily that, through its receptor, fibroblast growth factor-..
  3. Chorianopoulos E, Jarr K, Steen H, Giannitsis E, Frey N, Katus H. Soluble TWEAK is markedly upregulated in patients with ST-elevation myocardial infarction and related to an adverse short-term outcome. Atherosclerosis. 2010;211:322-6 pubmed publisher
    Soluble TWEAK has recently been introduced as a potential mediator of cardiovascular disease...
  4. Moreno J, Munoz Garcia B, Martin Ventura J, Madrigal Matute J, Orbe J, Paramo J, et al. The CD163-expressing macrophages recognize and internalize TWEAK: potential consequences in atherosclerosis. Atherosclerosis. 2009;207:103-10 pubmed publisher
    CD163 is a new potential scavenger receptor of Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) which elicits diverse biologic actions involved in atherosclerosis...
  5. Michaelson J, Wisniacki N, Burkly L, Putterman C. Role of TWEAK in lupus nephritis: a bench-to-bedside review. J Autoimmun. 2012;39:130-42 pubmed publisher
    ..In this review, we highlight the role of the TWEAK/Fn14 pathway in mediating key pathologic processes underlying LN involving both glomerular and tubular injury, and ..
  6. Liu Z, Zhou Q, Li X, Yang J, Ao X, Veeraragoo P, et al. Elevation of human tumor necrosis factor-like weak inducer of apoptosis in peripheral blood mononuclear cells is correlated with disease activity and lupus nephritis in patients with systemic lupus erythematosus. Cytokine. 2011;53:295-300 pubmed publisher
    Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a recently identified proinflammatory cytokine of the TNF superfamily...
  7. Jain M, Jakubowski A, Cui L, Shi J, Su L, Bauer M, et al. A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. Circulation. 2009;119:2058-68 pubmed publisher
    Tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor superfamily, is a multifunctional cytokine known to regulate cellular functions in contexts of injury and disease through its receptor, ..
  8. Yanaba K, Yoshizaki A, Muroi E, Hara T, Ogawa F, Usui A, et al. Elevated circulating TWEAK levels in systemic sclerosis: association with lower frequency of pulmonary fibrosis. J Rheumatol. 2009;36:1657-62 pubmed publisher
    To determine serum levels of tumor necrosis factor-related weak inducer of apoptosis (TWEAK) and its clinical associations in patients with systemic sclerosis (SSc). Serum TWEAK levels from 70 patients with SSc were examined by ELISA...
  9. Vince J, Chau D, Callus B, Wong W, Hawkins C, Schneider P, et al. TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha. J Cell Biol. 2008;182:171-84 pubmed publisher
    ..TNF-like weak inducer of apoptosis (TWEAK)/FN14 signaling nevertheless promotes the same noncanonical NF-kappaB signaling elicited by IAP antagonists and, ..
  10. Kaptein A, Jansen M, Dilaver G, Kitson J, Dash L, Wang E, et al. Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3). FEBS Lett. 2000;485:135-41 pubmed
    ..b>TWEAK, a novel TNF-related molecule, has been proposed as the ligand for this receptor...
  11. Yilmaz M, Carrero J, Martin Ventura J, Sonmez A, Saglam M, Celik T, et al. Combined therapy with renin-angiotensin system and calcium channel blockers in type 2 diabetic hypertensive patients with proteinuria: effects on soluble TWEAK, PTX3, and flow-mediated dilation. Clin J Am Soc Nephrol. 2010;5:1174-81 pubmed publisher
    ..Two surrogate biomarkers of endothelial function are therefore identified with potential as therapeutic targets. The study was registered in clinicaltrials.gov as NCT00921570. ..
  12. Brown S, Hanscom H, Vu H, Brew S, Winkles J. TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules. Biochem J. 2006;397:297-304 pubmed
    b>TWEAK [TNF (tumour necrosis factor)-like weak inducer of apoptosis] is a member of the TNF superfamily of cytokines...
  13. Perper S, Browning B, Burkly L, Weng S, Gao C, Giza K, et al. TWEAK is a novel arthritogenic mediator. J Immunol. 2006;177:2610-20 pubmed
    TNF-like weak inducer of apoptosis (TWEAK) is a TNF family member with pleiotropic effects on a variety of cell types, one of which is the induction of proinflammatory cytokines by synovial fibroblasts derived from rheumatoid arthritis (..
  14. Michaelson J, Cho S, Browning B, Zheng T, Lincecum J, Wang M, et al. Tweak induces mammary epithelial branching morphogenesis. Oncogene. 2005;24:2613-24 pubmed
    ..b>Tweak (TNF-related weak inducer of apoptosis) has pleiotropic biological functions including proapoptotic, proangiogenic ..
  15. Nakayama M, Ishidoh K, Kayagaki N, Kojima Y, Yamaguchi N, Nakano H, et al. Multiple pathways of TWEAK-induced cell death. J Immunol. 2002;168:734-43 pubmed
    b>TWEAK, a recently identified member of the TNF family, is expressed on IFN-gamma-stimulated monocytes and induces cell death in certain tumor cell lines...
  16. Tran N, McDonough W, Savitch B, Fortin S, Winkles J, Symons M, et al. Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome. Cancer Res. 2006;66:9535-42 pubmed
    ..Activation of Fn14 signaling by the ligand TNF-like weak inducer of apoptosis (TWEAK) stimulates migration and up-regulates expression of Fn14; this TWEAK effect requires Rac1 and nuclear factor-..
  17. Sanchez Nino M, Poveda J, Sanz A, Mezzano S, Carrasco S, Fernández Fernández B, et al. Fn14 in podocytes and proteinuric kidney disease. Biochim Biophys Acta. 2013;1832:2232-43 pubmed publisher
    ..We have now explored the regulation and role of TWEAK receptor Fn14 in mediating glomerular inflammation in cultured podocytes and in experimental and human non-immune ..
  18. Sanz A, Sanchez Niño M, Ortiz A. TWEAK, a multifunctional cytokine in kidney injury. Kidney Int. 2011;80:708-18 pubmed publisher
    Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a cytokine of the TNF superfamily that activates the Fn14 receptor. TWEAK may regulate cell proliferation, cell death, cell differentiation, and inflammation...
  19. Alexaki V, Notas G, Pelekanou V, Kampa M, Valkanou M, Theodoropoulos P, et al. Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development. J Immunol. 2009;183:5948-56 pubmed publisher
    ..factor of the TNF Family (BAFF), a proliferation inducing ligand (APRIL), and TNF-like weak inducer of apoptosis (TWEAK) in immature-appearing and mature adipocytes and in benign and malignant adipose tissue-derived tumors...
  20. Schwartz N, Rubinstein T, Burkly L, Collins C, Blanco I, Su L, et al. Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study. Arthritis Res Ther. 2009;11:R143 pubmed publisher
    TNF-like weak inducer of apoptosis (TWEAK) has been implicated as a mediator of chronic inflammatory processes via prolonged activation of the NF-kappaB pathway in several tissues, including the kidney...
  21. Karadurmus N, Tapan S, Cakar M, Naharci I, Celik T, Tasci I, et al. Lower plasma soluble TWEAK concentration in patients with newly diagnosed hypertension. Clin Invest Med. 2012;35:E20-6 pubmed
    ..5 ± 1.9 years, BMI 24.7 ± 1.5 kg/m2) were studied. Serums TWEAK and plasma asymmetrical dimethyl arginine (ADMA) levels were measured by EIA...
  22. Kim S, Kang Y, Kim W, Woo D, Lee Y, Kim D, et al. TWEAK can induce pro-inflammatory cytokines and matrix metalloproteinase-9 in macrophages. Circ J. 2004;68:396-9 pubmed
    The expression of TWEAK (TNFSF12) and TweakR/Fn14 was detected in regions rich in macrophage/foam cells in atherosclerotic plaques...
  23. Tran N, McDonough W, Savitch B, Sawyer T, Winkles J, Berens M. The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression. J Biol Chem. 2005;280:3483-92 pubmed
    ..Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-stimulated glioma cells had increased cellular resistance to cytotoxic therapy-induced apoptosis...
  24. Yepes M, Brown S, Moore E, Smith E, Lawrence D, Winkles J. A soluble Fn14-Fc decoy receptor reduces infarct volume in a murine model of cerebral ischemia. Am J Pathol. 2005;166:511-20 pubmed
    Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily. TWEAK acts on responsive cells via binding to a small cell surface receptor named Fn14...
  25. Urbonaviciene G, Martin Ventura J, Lindholt J, Urbonavicius S, Moreno J, Egido J, et al. Impact of soluble TWEAK and CD163/TWEAK ratio on long-term cardiovascular mortality in patients with peripheral arterial disease. Atherosclerosis. 2011;219:892-9 pubmed publisher
    ..72-0.86) vs. 0.84 (0.78-0.90), p = 0.019). Decreased sTWEAK concentration, and increased sCD163/sTWEAK ratio were significantly and independently associated with long-term cardiovascular mortality in patients with lower-extremity PAD. ..
  26. Campbell S, Michaelson J, Burkly L, Putterman C. The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity. Front Biosci. 2004;9:2273-84 pubmed
    ..TNF-like weak inducer of apoptosis (TWEAK), a recently identified member of the TNF ligand family, induces PGE2, MMP-1, IL-6, IL-8, RANTES, and IP-10 in ..
  27. Wang C, Chen L, Pan H, Leng R, Qin W, Ye D. Expression of human tumor necrosis factor-like weak inducer of apoptosis in patients with systemic lupus erythematosus. Clin Rheumatol. 2012;31:335-9 pubmed publisher
    ..study was to compare the mRNA and serum expression of tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) in patients with systemic lupus erythematosus (SLE) and healthy controls...
  28. Dohi T, Burkly L. The TWEAK/Fn14 pathway as an aggravating and perpetuating factor in inflammatory diseases: focus on inflammatory bowel diseases. J Leukoc Biol. 2012;92:265-79 pubmed publisher
    The TWEAK/Fn14 pathway is a ligand/receptor pair of the TNFSF that has emerged as a prominent player in normal and pathological tissue remodeling...
  29. Yilmaz M, Sonmez A, Ortiz A, Saglam M, Kilic S, Eyileten T, et al. Soluble TWEAK and PTX3 in nondialysis CKD patients: impact on endothelial dysfunction and cardiovascular outcomes. Clin J Am Soc Nephrol. 2011;6:785-92 pubmed publisher
    ..Now, we hypothesize that both sTWEAK and PTX3 act as biomarkers of cardiovascular outcomes in nondialysis CKD patients...
  30. Harada N, Nakayama M, Nakano H, Fukuchi Y, Yagita H, Okumura K. Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2002;299:488-93 pubmed
    b>TWEAK, a member of the TNF family, induces cell death in some tumor cell lines, but also induces proliferation of endothelial cells and angiogenesis...
  31. Ikner A, Ashkenazi A. TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8. J Biol Chem. 2011;286:21546-54 pubmed publisher
    The tumor necrosis factor (TNF) superfamily member TNF-like weak inducer of apoptosis (TNFSF12, CD255) (TWEAK) can stimulate apoptosis in certain cancer cells...
  32. Jakubowski A, Browning B, Lukashev M, Sizing I, Thompson J, Benjamin C, et al. Dual role for TWEAK in angiogenic regulation. J Cell Sci. 2002;115:267-74 pubmed
    ..b>TWEAK, a novel member of the tumor necrosis factor family, appears to be a pro-angiogenic agent on the basis of previous ..
  33. Dharmapatni A, Smith M, Crotti T, Holding C, Vincent C, Weedon H, et al. TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis. Arthritis Res Ther. 2011;13:R51 pubmed publisher
    TNF-like weak inducer of apoptosis (TWEAK) has been proposed as a mediator of inflammation and bone erosion in rheumatoid arthritis (RA)...
  34. Brown S, Richards C, Hanscom H, Feng S, Winkles J. The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation. Biochem J. 2003;371:395-403 pubmed
    ..was recently identified as a cell-surface receptor for the tumour necrosis factor (TNF) superfamily member named TWEAK (TNF-like weak inducer of apoptosis)...
  35. Bover L, Cardo Vila M, Kuniyasu A, Sun J, Rangel R, Takeya M, et al. A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications. J Immunol. 2007;178:8183-94 pubmed
    b>TWEAK (TNF-like weak inducer of apoptosis) is a TNF superfamily member implicated in several mechanisms...
  36. Moreno J, Dejouvencel T, Labreuche J, Smadja D, Dussiot M, Martin Ventura J, et al. Peripheral artery disease is associated with a high CD163/TWEAK plasma ratio. Arterioscler Thromb Vasc Biol. 2010;30:1253-62 pubmed publisher
    ..complexes, CD163 is a macrophage scavenger receptor for tumor necrosis factor-like weak inducer of apoptosis (TWEAK)...
  37. Nakayama M, Ishidoh K, Kojima Y, Harada N, Kominami E, Okumura K, et al. Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. J Immunol. 2003;170:341-8 pubmed
    b>TWEAK, a TNF family member, is produced by IFN-gamma-stimulated monocytes and induces multiple pathways of cell death, including caspase-dependent apoptosis, cathepsin B-dependent necrosis, and endogenous TNF-alpha-mediated cell death, ..
  38. Przybylowski P, Malyszko J, Malyszko J. Soluble tumor necrosis factor-like weak inducer of apoptosis plasma levels as a novel biomarker of endothelial function in prevalent orthotopic heart transplant recipients. Transplant Proc. 2011;43:1900-3 pubmed publisher
    ..Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a member of the TNF superfamily of cytokines...
  39. Yamana J, Morand E, Manabu T, Sunahori K, Takasugi K, Makino H, et al. Inhibition of TNF-induced IL-6 by the TWEAK-Fn14 interaction in rheumatoid arthritis fibroblast like synoviocytes. Cell Immunol. 2012;272:293-8 pubmed publisher
    TNF-like weak inducer of apoptosis (TWEAK), a member of the TNF superfamily, has been shown to increase cytokine production by rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS)...
  40. Serafini B, Magliozzi R, Rosicarelli B, Reynolds R, Zheng T, Aloisi F. Expression of TWEAK and its receptor Fn14 in the multiple sclerosis brain: implications for inflammatory tissue injury. J Neuropathol Exp Neurol. 2008;67:1137-48 pubmed publisher
    The expression patterns of tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a pleiotropic cytokine with proinflammatory and cell death-inducing activities, and its receptor, fibroblast growth factor-inducible 14 (Fn14), were ..
  41. Zhi Chun L, Qiao Ling Z, Zhi Qin L, Xiao Zhao L, Xiao xia Z, Rong T. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) mediates p38 mitogen-activated protein kinase activation and signal transduction in peripheral blood mononuclear cells from patients with lupus nephritis. Inflammation. 2012;35:935-43 pubmed publisher
    ..PBMCs) were treated with a p38 inhibitor (SB203580) or anti-tumor necrosis factor-like weak inducer of apoptosis (TWEAK) mAb, with or without phytohemagglutinin/phorbol myristate acetate (PHA/PMA) stimulation...
  42. Wiley S, Cassiano L, Lofton T, Davis Smith T, Winkles J, Lindner V, et al. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity. 2001;15:837-46 pubmed
    b>TWEAK is a member of the TNF ligand family that induces angiogenesis in vivo. We report cloning of a receptor for TWEAK (TweakR) from a human umbilical vein endothelial cell (HUVEC) library...
  43. Lynch C, Wang Y, Lund J, Chen Y, Leal J, Wiley S. TWEAK induces angiogenesis and proliferation of endothelial cells. J Biol Chem. 1999;274:8455-9 pubmed
    b>TWEAK is a recently described member of the Tumor Necrosis Factor (TNF) ligand family whose transcripts are present in a wide variety of human tissues (Chicheportiche, Y., Bourdon, P. R., Xu, H., Hsu Y. M., Scott, H., Hession, C...
  44. Martin Ventura J, Lindholt J, Moreno J, Vega de Ceniga M, Meilhac O, Michel J, et al. Soluble TWEAK plasma levels predict expansion of human abdominal aortic aneurysms. Atherosclerosis. 2011;214:486-9 pubmed publisher
    ..208; p = 0.046). sTWEAK plasma levels were decreased in subjects with AAA and were independently related with AAA expansion rate indicating that this protein could be a novel diagnostic and prognostic biomarker of AAA. ..
  45. Petitbarat M, Serazin V, Dubanchet S, Wayner R, De Mazancourt P, Chaouat G, et al. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor inducible-14 might regulate the effects of interleukin 18 and 15 in the human endometrium. Fertil Steril. 2010;94:1141-3 pubmed publisher
    Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) could play a role in the regulation of interleukin (IL)-15 and IL-18, cytokines crucial for angiogenesis and uterine natural killer (uNK) cell recruitment during embryo ..
  46. Jelic Ivanovic Z, Bujisic N, Spasic S, Bogavac Stanojevic N, Spasojevic Kalimanovska V, Kotur Stevuljevic J. Circulating sTWEAK improves the prediction of coronary artery disease. Clin Biochem. 2009;42:1381-6 pubmed publisher
    ..011-0.035). The measurement of serum sTWEAK concentrations improves the prediction of CAD based on existing biomarkers. ..
  47. Carrero J, Ortiz A, Qureshi A, Martin Ventura J, Barany P, Heimburger O, et al. Additive effects of soluble TWEAK and inflammation on mortality in hemodialysis patients. Clin J Am Soc Nephrol. 2009;4:110-8 pubmed publisher
    ..Further studies on the potential different role of sTWEAK in health and disease are warranted. ..
  48. Dai L, Gu L, Ding C, Qiu L, Di W. TWEAK promotes ovarian cancer cell metastasis via NF-kappaB pathway activation and VEGF expression. Cancer Lett. 2009;283:159-67 pubmed publisher
    ..It has been demonstrated that tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor inducible-14 (Fn14) signaling system may be a potential regulator of human tumorigenesis...
  49. Desplat Jego S, Feuillet L, Creidy R, Malikova I, Rance R, Khrestchatisky M, et al. TWEAK is expressed at the cell surface of monocytes during multiple sclerosis. J Leukoc Biol. 2009;85:132-5 pubmed publisher
    The TNF superfamily ligand, TNF-like weak inducer of apoptosis (TWEAK), regulates cellular responses ranging from proliferation to cell death in a manner highly dependent on the cell type and the microenvironmental context...
  50. Dogra C, Hall S, Wedhas N, Linkhart T, Kumar A. Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis. J Biol Chem. 2007;282:15000-10 pubmed
    ..factor-inducible 14 (Fn14), distantly related to tumor necrosis factor receptor superfamily and a receptor for TWEAK cytokine, has been implicated in several biological responses...
  51. Turkmen K, Tonbul H, Erdur F, Toker A, Biyik Z, Ozbiner H, et al. Soluble TWEAK independently predicts atherosclerosis in renal transplant patients. BMC Nephrol. 2013;14:144 pubmed publisher
    ..Cross-sectional analysis in which CIMT measurements, NLR and serum TWEAK levels were assessed in 70 Rtx patients (29 females; mean age, 40.6?±?12...
  52. Zimmermann M, Koreck A, Meyer N, Basinski T, Meiler F, Simone B, et al. TNF-like weak inducer of apoptosis (TWEAK) and TNF-? cooperate in the induction of keratinocyte apoptosis. J Allergy Clin Immunol. 2011;127:200-7, 207.e1-10 pubmed publisher
    ..TNF-like weak inducer of apoptosis (TWEAK) binds to its receptor, fibroblast growth factor-inducible 14 (Fn14), and controls many cellular activities, ..
  53. Vendrell J, Maymó Masip E, Tinahones F, Garcia Espana A, Megia A, Caubet E, et al. Tumor necrosis-like weak inducer of apoptosis as a proinflammatory cytokine in human adipocyte cells: up-regulation in severe obesity is mediated by inflammation but not hypoxia. J Clin Endocrinol Metab. 2010;95:2983-92 pubmed publisher
    ..We previously reported the up-regulation of TNF-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) axis in adipose tissue of severely obese type 2 diabetic subjects...
  54. Ortiz A, Sanz A, Munoz Garcia B, Moreno J, Sanchez Nino M, Martin Ventura J, et al. Considering TWEAK as a target for therapy in renal and vascular injury. Cytokine Growth Factor Rev. 2009;20:251-8 pubmed publisher
    b>TWEAK is a cytokine of the TNF superfamily that activates the Fn14 receptor. TWEAK may regulate cell proliferation, cell death, cell differentiation, angiogenesis and inflammation...
  55. Llauradó G, González Clemente J, Maymó Masip E, Subías D, Vendrell J, Chacon M. Serum levels of TWEAK and scavenger receptor CD163 in type 1 diabetes mellitus: relationship with cardiovascular risk factors. a case-control study. PLoS ONE. 2012;7:e43919 pubmed publisher
    ..Additionally, T1DM men have higher serum concentrations of sCD163. These results point out an association between the inflammatory system and CV risk in T1DM. ..
  56. Maymó Masip E, Fernández Veledo S, Garcia Espana A, Vázquez Carballo A, Tinahones F, Garcia Fuentes E, et al. The rise of soluble TWEAK levels in severely obese subjects after bariatric surgery may affect adipocyte-cytokine production induced by TNF?. J Clin Endocrinol Metab. 2013;98:E1323-33 pubmed publisher
    ..In human adipocytes, sTWEAK down-regulates TNF? cytokine production by hampering TNF? intracellular signaling events. The decrease of sTWEAK in severely obese patients may favor the proinflammatory activity elicited by TNF?. ..
  57. Kaplan M, Ray D, Mo R, Yung R, Richardson B. TRAIL (Apo2 ligand) and TWEAK (Apo3 ligand) mediate CD4+ T cell killing of antigen-presenting macrophages. J Immunol. 2000;164:2897-904 pubmed
    ..that TNF-related apoptosis-inducing ligand (TRAIL), interacting with Apo2, and TNF-like weak inducer of apoptosis (TWEAK), interacting with Apo3, will induce apoptosis in some cells...