TUCAN

Summary

Gene Symbol: TUCAN
Description: caspase recruitment domain family member 8
Alias: CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN, caspase recruitment domain-containing protein 8, CARD inhibitor of NF-kappaB-activating ligands, apoptotic protein NDPP1, tumor up-regulated CARD-containing antagonist of CASP9, tumor up-regulated CARD-containing antagonist of caspase nine
Species: human
Products:     TUCAN

Top Publications

  1. Bagnall R, Roberts R, Mirza M, Torigoe T, Prescott N, Mathew C. Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation. Eur J Hum Genet. 2008;16:619-25 pubmed publisher
    CARD8 (TUCAN) is implicated in the regulation of apoptosis and inflammation, and is a positional and functional candidate gene for inflammatory bowel disease (IBD)...
  2. Bouchier Hayes L, Conroy H, Egan H, Adrain C, Creagh E, MacFarlane M, et al. CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways. J Biol Chem. 2001;276:44069-77 pubmed
    ..Here we report the identification of a novel protein, CARDINAL, that contains a CARD motif and also exhibits a high degree of homology to the C terminus of DEFCAP/NAC, a ..
  3. Verma D, Lerm M, Blomgran Julinder R, Eriksson P, Söderkvist P, Särndahl E. Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases?. Arthritis Rheum. 2008;58:888-94 pubmed publisher
    NALP3, ASC, and TUCAN are components of the NALP3 inflammasome, which triggers caspase 1-mediated interleukin-1beta (IL-1beta) release...
  4. Roberts R, Topless R, Phipps Green A, Gearry R, Barclay M, Merriman T. Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease. Genes Immun. 2010;11:351-6 pubmed publisher
    ..48-0.90); P(1,1/1,2)=0.015, OR=0.35, 95% CI (0.15-0.82)). We propose that these genotype combinations protect against gut inflammation by preventing the NALP3 inflammasome from producing excessive interleukin-1beta. ..
  5. Stilo R, Leonardi A, Formisano L, Di Jeso B, Vito P, Liguoro D. TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation. FEBS Lett. 2002;521:165-9 pubmed
    ..TUCAN/CARDINAL is a recently identified CARD-containing protein involved in regulation of caspases and NF-kappaB activation...
  6. Agostini L, Martinon F, Burns K, McDermott M, Hawkins P, Tschopp J. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity. 2004;20:319-25 pubmed
    ..Here, we report that NALP2 and NALP3 associate with ASC, the CARD-containing protein Cardinal, and caspase-1 (but not caspase-5), thereby forming an inflammasome with high proIL-1beta-processing activity...
  7. Fontalba A, Gutierrez O, Llorca J, Mateo I, Berciano J, Fernandez Luna J, et al. Deficiency of CARD8 is associated with increased Alzheimer's disease risk in women. Dement Geriatr Cogn Disord. 2008;26:247-50 pubmed publisher
    ..39-fold higher risk of developing AD than subjects with the CARD8 TT genotype (full-length protein). This association with susceptibility to AD was independent of the ApoE epsilon4 allele. ..
  8. Schoultz I, Verma D, Halfvarsson J, Torkvist L, Fredrikson M, Sjoqvist U, et al. Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men. Am J Gastroenterol. 2009;104:1180-8 pubmed publisher
    ..These findings give further support to the importance of innate immune responses in CD. ..
  9. McGovern D, Butler H, Ahmad T, Paolucci M, van Heel D, Negoro K, et al. TUCAN (CARD8) genetic variants and inflammatory bowel disease. Gastroenterology. 2006;131:1190-6 pubmed
    ..Other susceptibility loci exist. TUCAN (CARD8) is located beneath a CD peak of linkage on chromosome 19q...

More Information

Publications116 found, 100 shown here

  1. García Bermúdez M, López Mejías R, Gonzalez Juanatey C, Corrales A, Castañeda S, Ortiz A, et al. CARD8 rs2043211 (p.C10X) polymorphism is not associated with disease susceptibility or cardiovascular events in Spanish rheumatoid arthritis patients. DNA Cell Biol. 2013;32:28-33 pubmed publisher
    ..In summary, our results do not support a role of the CARD8 rs2043211 gene variant in susceptibility to RA or in the development of CV disease in patients with RA. ..
  2. Razmara M, Srinivasula S, Wang L, Poyet J, Geddes B, DiStefano P, et al. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. J Biol Chem. 2002;277:13952-8 pubmed
    ..Overexpression of CARD-8 can also induce apoptosis in transfected cells. The results suggest that CARD-8 represents a new signaling molecule involved in the regulation of caspase-1 and NF-kappaB activation. ..
  3. Kastbom A, Johansson M, Verma D, Söderkvist P, Rantapaa Dahlqvist S. CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis. Ann Rheum Dis. 2010;69:723-6 pubmed publisher
    ..CARD8 and NLRP3 genotypes did not influence radiological joint damage and were not associated with an increased susceptibility. Carriage of CARD8-X is associated with a worse disease course in early RA. ..
  4. Ko D, Shukla K, Fong C, Wasnick M, Brittnacher M, Wurfel M, et al. A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease. Am J Hum Genet. 2009;85:214-27 pubmed publisher
    ..These results demonstrate the utility of genome-wide cell-based association screens with microbes in the identification of naturally selected variants that can impact human health. ..
  5. Roberts R, Van Rij A, Phillips L, Young S, McCormick S, Merriman T, et al. Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms. Atherosclerosis. 2011;218:123-6 pubmed publisher
    ..75; p=0.012); and separately for NOD2 genotype (?(2)=14.06; p=0.015). Our finding suggests genetic variability within the NLRP3 inflammasome may be important in the pathophysiology of AAA. ..
  6. Pathan N, Marusawa H, Krajewska M, Matsuzawa S, Kim H, Okada K, et al. TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer. J Biol Chem. 2001;276:32220-9 pubmed
    ..is overexpressed in some types of cancer and that binds and suppresses activation of procaspase-9, which we term TUCAN (tumor-up-regulated CARD-containing antagonist of caspase nine)...
  7. Henckaerts L, Pierik M, Joossens M, Ferrante M, Rutgeerts P, Vermeire S. Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease. Gut. 2007;56:1536-42 pubmed
    ..receptor genes (nucleotide oligomerisation domain (NOD) 2/caspase recruitment domain (CARD) 15, NOD1/CARD4, TUCAN/CARDINAL/CARD8, Toll-like receptor (TLR) 4, TLR2, TLR1 and TLR6) on the development of antimicrobial and antiglycan ..
  8. Fontalba A, Martinez Taboada V, Gutierrez O, Pipaon C, Benito N, Balsa A, et al. Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity. J Immunol. 2007;179:4867-73 pubmed
    ..03) than the CARD8-L allele carriers. Overall, our findings provide molecular insight into the expression of CARD8 by NF-kappaB, and suggest that a deleterious polymorphism of CARD8 may help predict the severity of RA. ..
  9. von Kampen O, Lipinski S, Till A, Martin S, Nietfeld W, Lehrach H, et al. Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling. J Biol Chem. 2010;285:19921-6 pubmed publisher
    ..Thus, CARD8 represents a novel molecular switch involved in the endogenous regulation of NOD2-dependent inflammatory processes in epithelial cells. ..
  10. Yang S, Kim H, Hong M, Lim J, Choi E, Ye B, et al. Association of CARD8 with inflammatory bowel disease in Koreans. J Hum Genet. 2011;56:217-23 pubmed publisher
    ..The stop allele of rs2043211 was associated with higher serum interleukin-1? levels only in female patients with UC (P = 0.027). Our data suggest that CARD8 variants might have roles in the pathogenesis of CD and UC in Koreans. ..
  11. Paramel G, Folkersen L, Strawbridge R, Elmabsout A, Särndahl E, Lundman P, et al. CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation. Clin Sci (Lond). 2013;125:401-7 pubmed publisher
    ..However, no significant association could be detected between this polymorphism and MI in the two cohorts. Genetic alterations in the CARD8 gene therefore seem to be of limited importance for the development of MI. ..
  12. Larabee C, Desai S, Agasing A, Georgescu C, Wren J, Axtell R, et al. Loss of Nrf2 exacerbates the visual deficits and optic neuritis elicited by experimental autoimmune encephalomyelitis. Mol Vis. 2016;22:1503-1513 pubmed
    ..a well-established model of MS in which mice are immunized to produce a neuroautoimmunity that recapitulates the cardinal hallmarks of human disease, namely, inflammation, demyelination, and neurodegeneration of the brain, spinal cord, ..
  13. Mangge H, Stelzer I, Reininghaus E, Weghuber D, Postolache T, Fuchs D. Disturbed tryptophan metabolism in cardiovascular disease. Curr Med Chem. 2014;21:1931-7 pubmed
    ..The review leads to a novel framework for successful therapeutic modification of several cardinal pathophysiological processes leading to adverse cardiovascular outcome.
  14. Gupta R, Motiwala M, Mahajan U, Sabre S. Protective effect of Sesbania grandiflora on acetic acid induced ulcerative colitis in mice by inhibition of TNF-? and IL-6. J Ethnopharmacol. 2018;219:222-232 pubmed publisher
    ..The cardinal inflammatory biomarkers like nitric oxide (NO), tumor necrosis factor-? (TNF-?) and interleukin (IL-6) were ..
  15. Bonkovsky H, Guo J, Hou W, Li T, Narang T, Thapar M. Porphyrin and heme metabolism and the porphyrias. Compr Physiol. 2013;3:365-401 pubmed publisher
    ..The cardinal clinical features are cutaneous (due to the skin-damaging effects of excess deposited porphyrins) or ..
  16. Atwood C, Bowen R. The endocrine dyscrasia that accompanies menopause and andropause induces aberrant cell cycle signaling that triggers re-entry of post-mitotic neurons into the cell cycle, neurodysfunction, neurodegeneration and cognitive disease. Horm Behav. 2015;76:63-80 pubmed publisher
    ..mitogenic Aβ; and the activation of Cdk5, a key regulator of cell cycle progression and tau phosphorylation (a cardinal feature of both neurogenesis and neurodegeneration)...
  17. Amorim I, Kedia S, Kouloulia S, Simbriger K, Gantois I, Jafarnejad S, et al. Loss of eIF4E Phosphorylation Engenders Depression-like Behaviors via Selective mRNA Translation. J Neurosci. 2018;38:2118-2133 pubmed publisher
    The MAPK/ERK (mitogen-activated protein kinases/extracellular signal-regulated kinase) pathway is a cardinal regulator of synaptic plasticity, learning, and memory in the hippocampus...
  18. Paredes J, Herren J, Schüpfer F, Marin R, Claverol S, Kuo C, et al. Genome sequence of the Drosophila melanogaster male-killing Spiroplasma strain MSRO endosymbiont. MBio. 2015;6: pubmed publisher
    ..genome is a valuable resource to explore the mechanisms of male killing and symbiont-mediated protection, two cardinal features of many facultative endosymbionts...
  19. Kakou Guikahue M, N guetta R, Anzouan Kacou J, Kramoh E, N Dori R, Ba S, et al. Optimizing the management of acute coronary syndromes in sub-Saharan Africa: A statement from the AFRICARDIO 2015 Consensus Team. Arch Cardiovasc Dis. 2016;109:376-83 pubmed publisher
    ..laboratories have been built in referral cardiology departments in large African towns (Abidjan and Dakar)...
  20. Mazor R, Manevich Mazor M, Kesler A, Aizenstein O, Eshed I, Jaffe R, et al. Clinical considerations and key issues in the management of patients with Erdheim-Chester Disease: a seven case series. BMC Med. 2014;12:221 pubmed publisher
    ..The objectives are to report the clinical, radiological and pathological characteristics, as well as cardinal therapeutic approaches to ECD patients and to provide clinical analyses of the medical chronicles of these ..
  21. Spitzweg C, Reincke M, Gartner R. [Thyroid emergencies : Thyroid storm and myxedema coma]. Internist (Berl). 2017;58:1011-1019 pubmed publisher
    ..b>Cardinal features of thyroid storm are myasthenia, cardiovascular symptoms, in particular tachycardia, as well as ..
  22. Eskandary F, Dürr M, Budde K, Doberer K, Reindl Schwaighofer R, Waiser J, et al. Clazakizumab in late antibody-mediated rejection: study protocol of a randomized controlled pilot trial. Trials. 2019;20:37 pubmed publisher
    Late antibody-mediated rejection (ABMR) triggered by donor-specific antibodies (DSA) is a cardinal cause of kidney allograft dysfunction and loss...
  23. Gupta S, Sharma U, Jagannathan N, Gupta Y. Neuroprotective effect of lercanidipine in middle cerebral artery occlusion model of stroke in rats. Exp Neurol. 2017;288:25-37 pubmed publisher
    Oxidative stress, inflammation and apoptotic neuronal cell death are cardinal mechanisms involved in the cascade of acute ischemic stroke...
  24. Butler M, Manzardo A. Androgen receptor (AR) gene CAG trinucleotide repeat length associated with body composition measures in non-syndromic obese, non-obese and Prader-Willi syndrome individuals. J Assist Reprod Genet. 2015;32:909-15 pubmed publisher
    ..in PWS and supporting the role of sex hormones and AR gene interaction in obesity and infertility, both cardinal features of PWS...
  25. Bakris G, Burkart J, Weinhandl E, McCullough P, Kraus M. Intensive Hemodialysis, Blood Pressure, and Antihypertensive Medication Use. Am J Kidney Dis. 2016;68:S15-S23 pubmed publisher
    Hypertension is a cardinal feature of end-stage renal disease (ESRD). Hypertensive nephropathy is the primary cause of ESRD for nearly 30% of patients, and the prevalence of hypertension is >85% in new patients with ESRD...
  26. Thonse R, Ashford R, Williams T, Harrington P. Differences in attitudes to analgesia in post-operative limb surgery put patients at risk of compartment syndrome. Injury. 2004;35:290-5 pubmed
    Missed compartment syndrome may result in severe disability. Complete masking of pain, the cardinal symptom of compartment syndrome, may contribute to delayed or missed diagnosis...
  27. Checinska A, Giaccone G, Hoogeland B, Ferreira C, Rodriguez J, Kruyt F. TUCAN/CARDINAL/CARD8 and apoptosis resistance in non-small cell lung cancer cells. BMC Cancer. 2006;6:166 pubmed
    ..of the present study was to investigate the mechanism of caspase-9 inhibition, with a focus on a possible role of TUCAN as caspase-9 inhibitor and a determinant of chemosensitivity in NSCLC cells...
  28. Clement L, Macé C, Del Nogal Avila M, Marshall C, Chugh S. The proteinuria-hypertriglyceridemia connection as a basis for novel therapeutics for nephrotic syndrome. Transl Res. 2015;165:499-504 pubmed publisher
    ..One way to elucidate these disease mechanisms is to study the association between the cardinal manifestations of glomerular diseases...
  29. Tagawa K. Hemichordate models. Curr Opin Genet Dev. 2016;39:71-78 pubmed publisher
    ..As adults, they exhibit cardinal chordate characters, such as gill slits...
  30. Wilson J, Khan Perez J, Marley D, Buttress S, Walton M, Li B, et al. Can shoulder range of movement be measured accurately using the Microsoft Kinect sensor?plus Medical Interactive Recovery Assistant (MIRA) software?. J Shoulder Elbow Surg. 2017;26:e382-e389 pubmed publisher
    ..There were 1670 measurements analyzed. The MIRA evaluations of all 4 cardinal shoulder movements were significantly more precise, with narrower limits of agreement, than the measurements of ..
  31. Lambova S, Müller Ladner U. Mosaic capillaroscopic findings in systemic sclerosis. Wien Med Wochenschr. 2018;168:248-249 pubmed publisher
    ..The generalized microangiopathy is a cardinal feature of SSc, but the underlying endothelial damage of the capillaries varies in the different compartments of ..
  32. Mathieu C, Beltra J, Charpentier T, Bourbonnais S, Di Santo J, Lamarre A, et al. IL-2 and IL-15 regulate CD8+ memory T-cell differentiation but are dispensable for protective recall responses. Eur J Immunol. 2015;45:3324-38 pubmed publisher
    The ability to mount effective secondary responses is a cardinal feature of memory CD8(+) T cells. An understanding of the factors that regulate the generation and recall capacities of memory T cells remains to be ascertained...
  33. Barnawi R, Al Khaldi S, Majed Sleiman G, Sarkar A, Al Dhfyan A, Al Mohanna F, et al. Fascin Is Critical for the Maintenance of Breast Cancer Stem Cell Pool Predominantly via the Activation of the Notch Self-Renewal Pathway. Stem Cells. 2016;34:2799-2813 pubmed publisher
    ..that we have previously demonstrated to be a major regulator of breast cancer chemoresistance and metastasis, two cardinal features of CSCs...
  34. Obeso I, Casabona E, Rodríguez Rojas R, Bringas M, Macías R, Pavón N, et al. Unilateral subthalamotomy in Parkinson's disease: Cognitive, psychiatric and neuroimaging changes. Cortex. 2017;94:39-48 pubmed publisher
    Unilateral subthalamotomy is an effective treatment for the cardinal motor features of Parkinson's disease (PD). However, non-motor changes possibly associated with right or left subthalamotomy remain unknown...
  35. Geyer F, Pareja F, Weigelt B, Rakha E, Ellis I, Schnitt S, et al. The Spectrum of Triple-Negative Breast Disease: High- and Low-Grade Lesions. Am J Pathol. 2017;187:2139-2151 pubmed publisher
    ..of usual triple-negative breast cancer, and the salivary gland-like tumors of the breast, lacking all the cardinal molecular features of conventional triple-negative breast cancer and underpinned by specific fusion genes or ..
  36. Govoni M, Bortoluzzi A, Rossi D, Modena V. How I treat patients with adult onset Still's disease in clinical practice. Autoimmun Rev. 2017;16:1016-1023 pubmed publisher
    ..onset Still's disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by four cardinal signs which are almost always present in patients: high spiking fever, arthralgia (with or without synovitis), ..
  37. Martinez Rios V, Østergaard N, Gkogka E, Rosshaug P, Dalgaard P. Modelling and predicting growth of psychrotolerant pseudomonads in milk and cottage cheese. Int J Food Microbiol. 2016;216:110-20 pubmed publisher
    ..The mathematical models include the effect of temperature, pH, NaCl, lactic acid and sorbic acid. A simplified cardinal parameter growth rate model was developed based on growth in broth...
  38. Rasheed M, Tripathi S, Mishra S, Singh M. Coherent and Contradictory Facts, Feats and Fictions Associated with Metal Accumulation in Parkinson's Disease: Epicenter or Outcome, Yet a Demigod Question. Mol Neurobiol. 2017;54:4738-4755 pubmed publisher
    ..accumulation has never been overlooked due to noteworthy similitude between metal-exposure symptoms and a few cardinal features of disease...
  39. Brown E, Polsky D, Barbu C, Seymour J, Grande D. Racial Disparities In Geographic Access To Primary Care In Philadelphia. Health Aff (Millwood). 2016;35:1374-81 pubmed publisher
    ..Because of primary care's cardinal importance, adequate access is an important health policy priority...
  40. Yamashita T, Yamamoto S, Zhang J, Kometani M, Tomiyama D, Kohno K, et al. Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury. PLoS ONE. 2016;11:e0165189 pubmed publisher
    ..of duloxetine in a model of neuropathic pain produced a reversal of nerve injury-induced mechanical allodynia, a cardinal symptom of neuropathic pain...
  41. Dore P, Dumani A, Wyatt G, Shepherd A. Links between global and local shape perception, coloured backgrounds, colour discrimination, and non-verbal IQ. Vision Res. 2018;151:31-40 pubmed publisher
    ..the local and global shape tasks that were tailored for the cone-opponent pathways early in the visual system (cardinal colour directions: L-M, loosely, reddish-greenish; and S-(L + M), or tritan colours, loosely, blueish-..
  42. Liu Y, Liu Y, Yip P, Akanuma K, Meguro K. More Delusions May Be Observed in Low-Proficient Multilingual Alzheimer's Disease Patients. PLoS ONE. 2015;10:e0140714 pubmed publisher
    ..with Alzheimer's disease (AD), according to the DSM-IV and NINCDS-ADRDA criteria, from the memory clinic of the Cardinal Tien Hospital in Taipei, Taiwan...
  43. Rodriguez J, Haskins I, Strong A, Plescia R, Allemang M, Butler R, et al. Per oral endoscopic pyloromyotomy for refractory gastroparesis: initial results from a single institution. Surg Endosc. 2017;31:5381-5388 pubmed publisher
    ..gastric emptying scintigraphy study and were asked to rate their symptoms using the Gastroparesis Cardinal Symptom Index (GCSI) at their pre-procedure visit and at 3 months post-procedure...
  44. Kim S, Lee B, Choi J, Kim J, Kim C, Shin H. Deficiency of a brain-specific chemokine-like molecule, SAM3, induces cardinal phenotypes of autism spectrum disorders in mice. Sci Rep. 2017;7:16503 pubmed publisher
  45. Mar G, Barrington M, McGuirk B. Acute compartment syndrome of the lower limb and the effect of postoperative analgesia on diagnosis. Br J Anaesth. 2009;102:3-11 pubmed publisher
    ..Pain is often described as the cardinal symptom of compartment syndrome, but many authors consider it unreliable...
  46. Brunyé T, Burte H, Houck L, Taylor H. The Map in Our Head Is Not Oriented North: Evidence from a Real-World Environment. PLoS ONE. 2015;10:e0135803 pubmed publisher
    ..is not a necessary feature of cognitive maps and instead may arise due to coincidental alignment between cardinal directions and the built and natural environment...
  47. Mohamed A, Ngom G, Sow M, Mbaye P, Camara S, Seck N, et al. [Scooter accidents in children at Aristide Le Dantec, Unversity Hospital of Dakar: a study of 74 cases]. Pan Afr Med J. 2016;23:32 pubmed publisher
    Scooter accidents are becoming more frequent in Dakar. The purpose of this study is to report the epidemiological and lesional aspects of these accidents on children in Dakar...
  48. Averill L, Purohit P, Averill C, Boesl M, Krystal J, Abdallah C. Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies. Neurosci Lett. 2017;649:147-155 pubmed publisher
    ..anxiety, and trauma-related disorders and dysfunction in glutamate neurotransmission is increasingly considered a cardinal feature of stress-related psychiatric disorders including PTSD...
  49. Rehulka J, Kolařík M, Hubka V. Disseminated infection due to Exophiala pisciphila in Cardinal tetra, Paracheirodon axelrodi. J Fish Dis. 2017;40:1015-1024 pubmed publisher
    b>Cardinal tetra, Paracheirodon axelrodi (Schultz, 1956), kept in an ornamental tank, was found to be affected by severe invasive mycosis...
  50. Skorecki K, Horton R. Israel: health and beyond. Lancet. 2017;389:2551-2562 pubmed publisher
    ..which is characterised by robust debate and discussion about the nation's future; national legislation governing cardinal health-care processes; cultural and religious histories that respect and revere scholarship, learning, research, ..
  51. Jung H, Castranova D, Swift M, Pham V, Venero Galanternik M, Isogai S, et al. Development of the larval lymphatic system in zebrafish. Development. 2017;144:2070-2081 pubmed publisher
    ..assembly of the major vessels of the trunk lymphatic vascular network, including the later-developing collateral cardinal, spinal, superficial lateral and superficial intersegmental lymphatics...
  52. Mu J, Chaudhuri K, Bielza C, de Pedro Cuesta J, Larrañaga P, Martinez Martin P. Parkinson's Disease Subtypes Identified from Cluster Analysis of Motor and Non-motor Symptoms. Front Aging Neurosci. 2017;9:301 pubmed publisher
    ..and well-characterized cohort of Parkinson's disease patients across all motor stages, using a combination of cardinal motor features (bradykinesia, rigidity, tremor, axial signs) and, for the first time, specific validated rater-..
  53. Deftereos G, Corrie S, Feng Q, Morihara J, Stern J, Hawes S, et al. Expression of mir-21 and mir-143 in cervical specimens ranging from histologically normal through to invasive cervical cancer. PLoS ONE. 2011;6:e28423 pubmed publisher
    ..142 formalin-fixed, paraffin embedded (FFPE) cervical biopsy tissue blocks, collected from Dantec Oncology Clinic, Dakar, Senegal. MicroRNA expression analysis was performed using Taqman-based real-time PCR assays...
  54. Itani H, Xiao L, Saleh M, Wu J, Pilkinton M, Dale B, et al. CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli. Circ Res. 2016;118:1233-43 pubmed publisher
    ..Formation of memory T cells, which requires the costimulatory molecule CD70 on antigen-presenting cells, is a cardinal feature of adaptive immunity...
  55. Yang Y, Castano C, Gupton B, Reber A, Khanna S. A fundamental analysis of enhanced cross-coupling catalytic activity for palladium clusters on graphene supports. Nanoscale. 2016;8:19564-19572 pubmed
    ..with the high activity of ligated homogeneous catalysts for the production of complex organic molecules is a cardinal goal of catalyst development...
  56. Kortüm F, Marquardt I, Alawi M, Korenke G, Spranger S, Meinecke P, et al. Acute Liver Failure Meets SOPH Syndrome: A Case Report on an Intermediate Phenotype. Pediatrics. 2017;139: pubmed publisher
    ..5741G>A [p.(Arg1914His)]. We present the case of a 4-year-old girl with the cardinal features of SOPH syndrome: characteristic facial dysmorphism, postnatal growth retardation, delay of bone age, ..
  57. Benedusi M, Frigato E, Beltramello M, Bertolucci C, Valacchi G. Circadian clock as possible protective mechanism to pollution induced keratinocytes damage. Mech Ageing Dev. 2018;172:13-20 pubmed publisher
    ..Moreover, analysis of clock gene expression profiles reveals a more rapid induction of the cardinal clock gene Bmal1 in entrained cells...
  58. Khan S, Ali S, Naeem M, Khan S, Husnain T, Butt N, et al. Splice-site mutations identified in PDE6A responsible for retinitis pigmentosa in consanguineous Pakistani families. Mol Vis. 2015;21:871-82 pubmed
    ..we report two splice acceptor site variations in PDE6A in consanguineous Pakistani families who manifested cardinal symptoms of RP...
  59. Wang J, Zheng Y, Hu H, Li J, Zhang L, Chen B, et al. Coupling of soil prokaryotic diversity and plant diversity across latitudinal forest ecosystems. Sci Rep. 2016;6:19561 pubmed publisher
    The belowground soil prokaryotic community plays a cardinal role in sustaining the stability and functions of forest ecosystems...
  60. Patten P, Ferrer G, Chen S, Simone R, Marsilio S, Yan X, et al. Chronic lymphocytic leukemia cells diversify and differentiate in vivo via a nonclassical Th1-dependent, Bcl-6-deficient process. JCI Insight. 2016;1: pubmed
    ..in B cell maturation, defects in T cell action, and absence of antigen-receptor diversification, which are often cardinal characteristics of CLL, are not inherent but imposed by external signals and the microenvironment...
  61. Zhao X, Gu C, Yan C, Zhang X, Li Y, Wang L, et al. NALP3-Inflammasome-Related Gene Polymorphisms in Patients with Prehypertension and Coronary Atherosclerosis. Biomed Res Int. 2016;2016:7395627 pubmed publisher
    ..This work suggests that the CTACATAA and CCACATAG haplotypes were associated with CHD in prehypertension patients in the NOD2 locus. ..
  62. Mbaye A, Gaye A, Dieye B, Ndiaye Y, Bei A, Affara M, et al. Ex vivo susceptibility and genotyping of Plasmodium falciparum isolates from Pikine, Senegal. Malar J. 2017;16:250 pubmed publisher
    ..In Senegal, the first cases of chloroquine resistance were reported in the Dakar region in 1988 with nearly 7% population prevalence, reaching 47% by 1990...
  63. Schroeder P, Nuerk H, Plewnia C. Prefrontal neuromodulation reverses spatial associations of non-numerical sequences, but not numbers. Biol Psychol. 2017;128:39-49 pubmed publisher
    ..to the universal origin of different SNARC effects and whether their underpinning is a spatial arrangement of cardinal magnitude (mental number line) or a sequential arrangement of ordinal elements in working memory...
  64. Carey S, Shusterman A, Haward P, Distefano R. Do analog number representations underlie the meanings of young children's verbal numerals?. Cognition. 2017;168:243-255 pubmed publisher
    Children learn to count, and even learn the cardinal meanings of the first three or four verbal numerals ("one" through "three" or "four"), before they master the numerical significance of counting...
  65. Spella M, Marazioti A, Arendt K, Stathopoulos G. RAS oncogenes direct metastasis. Mol Cell Oncol. 2017;4:e1345711 pubmed publisher
    i>RAS genes are cardinal driver oncogenes frequently and differentially mutated across bodily tumors. Their tumorigenic potential has been mainly ascribed to autonomous promotion of tumor cell proliferation and survival...
  66. Diongue K, Diallo M, Ndiaye M, Seck M, Badiane A, Ndiaye D. [Interdigital tinea pedis resulting from Fusarium spp. in Dakar, Senegal]. J Mycol Med. 2018;28:227-231 pubmed publisher
    ..Fusarium sp. is rarely incriminated in the genesis of intertrigo. In Dakar, a recent study conducted in 2016 on fungal ITP showed that Fusarium were more involved in the etiology of ITP ..
  67. Zielonka M, Garbade S, Kölker S, Hoffmann G, Ries M. A cross-sectional quantitative analysis of the natural history of Farber disease: an ultra-orphan condition with rheumatologic and neurological cardinal disease features. Genet Med. 2017;: pubmed publisher
    ..GENETICS in MEDICINE advance online publication, 19 October 2017; doi:10.1038/gim.2017.133...
  68. Distler M, Schlachetzki J, Kohl Z, Winkler J, Schenk T. Paradoxical kinesia in Parkinson's disease revisited: Anticipation of temporal constraints is critical. Neuropsychologia. 2016;86:38-44 pubmed publisher
    Slowness of movement, called bradykinesia is the cardinal symptom of Parkinson's disease. Under distinct but not yet well-defined circumstances, patients with Parkinson's disease are able to overcome bradykinesia...
  69. Burge J, McCann B, Geisler W. Estimating 3D tilt from local image cues in natural scenes. J Vis. 2016;16:2 pubmed publisher
    ..Rich results emerge: (a) typical tilt estimates are only moderately accurate and strongly influenced by the cardinal bias in the prior probability distribution; (b) when cue values are similar, or when slant is greater than 40°, ..
  70. Hochrainer Stigler S, Lorant A. Evaluating Partnerships to Enhance Disaster Risk Management using Multi-Criteria Analysis: An Application at the Pan-European Level. Environ Manage. 2018;61:24-33 pubmed publisher
    ..approach to determine set of options for new partnerships and test them in a high-level workshop via a novel cardinal ranking based multi-criteria approach...
  71. Range R, Wei Z. An anterior signaling center patterns and sizes the anterior neuroectoderm of the sea urchin embryo. Development. 2016;143:1523-33 pubmed publisher
    ..development, the sea urchin ANE territory separates into inner and outer regulatory domains that express the cardinal ANE transcriptional regulators FoxQ2 and Six3, respectively...
  72. MacDonald K, Moran A, Scherman A, McEvoy C, Platteau A. Maternal high-fat diet in mice leads to innate airway hyperresponsiveness in the adult offspring. Physiol Rep. 2017;5: pubmed publisher
    ..to investigate the effect of maternal high-fat diet (HFD) on adult offspring airway hyperreactivity (AHR), a cardinal feature of asthma...
  73. Nguyen Van Long N, Rigalma K, Coroller L, Dadure R, Debaets S, Mounier J, et al. Modelling the effect of water activity reduction by sodium chloride or glycerol on conidial germination and radial growth of filamentous fungi encountered in dairy foods. Food Microbiol. 2017;68:7-15 pubmed publisher
    ..The estimated cardinal values were then used for growth prediction and compared to growth kinetics observed on commercial fresh cheese...
  74. Sohail S, Yu L, Schneider J, Bennett D, Buchman A, Lim A. Sleep fragmentation and Parkinson's disease pathology in older adults without Parkinson's disease. Mov Disord. 2017;: pubmed publisher
    ..However, there are few data concerning the relationship between objectively quantified sleep disruption and the cardinal histopathological features of PD, especially in individuals without clinical PD.
  75. Kempermann G. Cynefin as Reference Framework to Facilitate Insight and Decision-Making in Complex Contexts of Biomedical Research. Front Neurosci. 2017;11:634 pubmed publisher
    ..and especially the brain and its diseases, are complex to the extent that complexity could be considered their cardinal feature, complex problems in biomedicine are often treated as if they were actually not more than the complicated ..
  76. Kastbom A, Verma D, Eriksson P, Skogh T, Wingren G, Soderkvist P. Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project). Rheumatology (Oxford). 2008;47:415-7 pubmed publisher
    ..We investigated whether two polymorphisms in the genes encoding cryopyrin (CIAS1) and TUCAN (CARD8) influence susceptibility and disease course in RA...
  77. Klapoetke N, Nern A, Peek M, Rogers E, Breads P, Rubin G, et al. Ultra-selective looming detection from radial motion opponency. Nature. 2017;551:237-241 pubmed publisher
    ..they each terminate in one of four retinotopic layers, such that each layer responds to motion in a different cardinal direction...
  78. Sturman N, Deckx L, Van Driel M. Methylphenidate for children and adolescents with autism spectrum disorder. Cochrane Database Syst Rev. 2017;11:CD011144 pubmed publisher
    ..spectrum disorder (ASD) frequently present with inattention, impulsivity and hyperactivity, which are the cardinal symptoms of attention deficit hyperactivity disorder (ADHD)...
  79. Pietra F. On the Dynamical Behavior of the Cysteine Dioxygenase-l-Cysteine Complex in the Presence of Free Dioxygen and l-Cysteine. Chem Biodivers. 2017;14: pubmed publisher
    ..These models pave the way to free energy studies of ligand associations, devised to better clarify how this cardinal enzyme behaves in human metabolism.
  80. Klinge M, Pedersen J, Schelde B, Lund S, Krogh K. [Workup and treatment of gastroparesis]. Ugeskr Laeger. 2017;179: pubmed
    Gastroparesis is defined as impaired gastric emptying without mechanical obstruction and cardinal symptoms including vomiting, nausea, early satiety, and upper abdominal pain...
  81. Paul A, Crow M, Raudales R, He M, Gillis J, Huang Z. Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity. Cell. 2017;171:522-539.e20 pubmed publisher
    ..We discovered that cardinal GABAergic neuron types are delineated by a transcriptional architecture that encodes their synaptic communication ..
  82. Jin D, Zhu D, Fang Y, Chen Y, Yu G, Pan W, et al. Vegfa signaling regulates diverse artery/vein formation in vertebrate vasculatures. J Genet Genomics. 2017;44:483-492 pubmed publisher
    ..embryos are embryonic lethal, and display a complete loss of the dorsal aorta (DA) and expansion of the cardinal vein...
  83. Zaki M, Issa M, Elbendary H, El Karaksy H, Hosny H, Ghobrial C, et al. Hypermanganesemia with dystonia, polycythemia and cirrhosis in 10 patients: Six novel SLC30A10 mutations and further phenotype delineation. Clin Genet. 2017;: pubmed publisher
    ..on T1W images, and variable degrees of extrapyramidal manifestations with or without liver disease were cardinal features in all patients. Eight patients presented with striking early diseased onset (<2 years)...
  84. Buning C, Schmidt H, Molnar T, Drenth J, Fiedler T, Gentz E, et al. No association of the CARD8 (TUCAN) c.30T>A (p.C10X) variant with Crohn's disease: a study in 3 independent European cohorts. Inflamm Bowel Dis. 2008;14:332-7 pubmed
    A recent study reported that the c.30T>A (p.Cys10Ter; rs2043211) variant, in the CARD8 (TUCAN) gene, is associated with Crohn's disease (CD). The aim of this study was to analyze the frequency of p...
  85. Sahdo B, Fransen K, Asfaw Idosa B, Eriksson P, Söderquist B, Kelly A, et al. Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome. PLoS ONE. 2013;8:e75457 pubmed publisher
    ..In spite of this, it could also represent the mechanisms by which the inflammatory loop is triggered into a long-term inflammatory phenotype. ..
  86. Lee C, Lin C, Leu S, Lee Y. Overexpression of Notch ligand Delta-like-1 by dendritic cells enhances their immunoregulatory capacity and exerts antiallergic effects on Th2-mediated allergic asthma in mice. Clin Immunol. 2018;187:58-67 pubmed publisher
    ..Furthermore, adoptive transfer of OVA-stimulated DLL1-DCs into asthmatic mice alleviated the cardinal features of allergic asthma, including immunoglobulin E (IgE) production, airway hyperresponsiveness (AHR), ..
  87. Fall B, Madamet M, Diawara S, Briolant S, Wade K, Lo G, et al. Ex vivo activity of Proveblue, a methylene blue, against field isolates of Plasmodium falciparum in Dakar, Senegal from 2013-2015. Int J Antimicrob Agents. 2017;50:155-158 pubmed publisher
    ..falciparum. In this context, the use of Proveblue as part of the triple ACT treatment for multidrug-resistant malaria warrants further investigation. ..
  88. Renard J, Szkudlarek H, Kramar C, Jobson C, Moura K, Rushlow W, et al. Adolescent THC Exposure Causes Enduring Prefrontal Cortical Disruption of GABAergic Inhibition and Dysregulation of Sub-Cortical Dopamine Function. Sci Rep. 2017;7:11420 pubmed publisher
    ..GABAergic hypofunction in the prefrontal cortex (PFC) is a cardinal pathological feature of schizophrenia and may be a mechanism by which the PFC loses its ability to regulate sub-..
  89. Mascarenhas J, Tchourbanov A, Danilov S, Zhou T, Wang T, Garcia J. The Splicing Factor hnRNPA1 Regulates Alternate Splicing of the MYLK Gene. Am J Respir Cell Mol Biol. 2017;: pubmed publisher
    Profound lung vascular permeability is a cardinal feature of Acute Respiratory Distress Syndrome (ARDS) and Ventilator-Induced Lung injury (VILI), two syndromes known to centrally involve the non-muscle isoform of myosin light chain ..
  90. Hutchinson D, Hines S, Vijayaraghavan N, Sammond A, Metzler Wilson K, Kuchera M. Interexaminer reliability study of a standardized myofascial diagnostic technique of the superior thoracic inlet. J Bodyw Mov Ther. 2017;21:658-663 pubmed publisher
    ..6 for each cardinal plane. The agreement phase comprised of testing 52 participants acquired agreements of 92.3% (rotation), 88...
  91. Karmouch J, Zhou Q, Miyake C, Lombardi R, Kretzschmar K, Bannier Hélaouët M, et al. Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes. Circ Res. 2017;121:1346-1359 pubmed publisher
    ..Ventricular arrhythmias are the cardinal and typically early manifestations, whereas myocardial fibroadiposis is the pathological hallmark...
  92. Demir K, Yildiz M, Bahat H, Goldman M, Hassan N, Tzur S, et al. Clinical Heterogeneity and Phenotypic Expansion of NaPi-IIa-Associated Disease. J Clin Endocrinol Metab. 2017;102:4604-4614 pubmed publisher
    NaPi-IIa, encoded by SLC34A1, is a key phosphate transporter in the mammalian proximal tubule and plays a cardinal role in renal phosphate handling...