TUBB8

Summary

Gene Symbol: TUBB8
Description: tubulin, beta 8 class VIII
Alias: bA631M21.2, HSA10p15 beta-tubulin 4Q, class VIII beta-tubulin, tubulin beta-8 chain
Species: human

Top Publications

  1. pmc HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim
    Dan Chen
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3206, USA
    EMBO J 21:6801-10. 2002
  2. pmc HIV-1 rev depolymerizes microtubules to form stable bilayered rings
    N R Watts
    Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    J Cell Biol 150:349-60. 2000
  3. ncbi Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression
    Mayte Coiras
    AIDS Immunopathology Unit, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Proteomics 6:S63-73. 2006
  4. ncbi Identification of a novel beta-tubulin subfamily with one member (TUBB4Q) located near the telomere of chromosome region 4q35
    M van Geel
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cytogenet Cell Genet 88:316-21. 2000
  5. pmc A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes
    Michel van Geel
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Am J Hum Genet 70:269-78. 2002

Detail Information

Publications5

  1. pmc HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim
    Dan Chen
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3206, USA
    EMBO J 21:6801-10. 2002
    ..Our findings reveal a strategy by which Tat induces apoptosis by targeting the microtubule network. Thus HIV-1 Tat joins a growing list of pathogen-derived proteins that target the cytoskeleton of host cells...
  2. pmc HIV-1 rev depolymerizes microtubules to form stable bilayered rings
    N R Watts
    Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    J Cell Biol 150:349-60. 2000
    ..These results suggest that Rev may interact with MTs to induce their destabilization, a proposition consistent with the previously described disruption of MTs after HIV-1 infection...
  3. ncbi Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression
    Mayte Coiras
    AIDS Immunopathology Unit, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Proteomics 6:S63-73. 2006
    ..In conclusion, in addition to its role in viral mRNA elongation, the proteomic approach has provided insight into the way that Tat modifies host cell gene expression...
  4. ncbi Identification of a novel beta-tubulin subfamily with one member (TUBB4Q) located near the telomere of chromosome region 4q35
    M van Geel
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cytogenet Cell Genet 88:316-21. 2000
    ..Although the chromosome 4q35 tubulin-member probably represents a pseudogene, ectopic expression due to a postulated position effect variegation (PEV), makes TUBB4Q an ideal dominant-negative candidate gene for FSHD1...
  5. pmc A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes
    Michel van Geel
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Am J Hum Genet 70:269-78. 2002
    ..Our analysis emphasizes the dynamic nature of duplication-mediated genome evolution and the delicate balance between gene acquisition and silencing...