TUBB6

Summary

Gene Symbol: TUBB6
Description: tubulin beta 6 class V
Alias: FPVEPD, HsT1601, TUBB-5, tubulin beta-6 chain, class V beta-tubulin, tubulin beta MGC4083, tubulin beta class V, tubulin, beta 6
Species: human
Products:     TUBB6

Top Publications

  1. Coiras M, Camafeita E, Ureña T, Lopez J, Caballero F, Fernández B, et al. Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression. Proteomics. 2006;6 Suppl 1:S63-73 pubmed
    ..In conclusion, in addition to its role in viral mRNA elongation, the proteomic approach has provided insight into the way that Tat modifies host cell gene expression. ..
  2. Beggs A, Mehta S, Deeks J, James J, Caldwell G, Dilworth M, et al. Validation of epigenetic markers to identify colitis associated cancer: Results of module 1 of the ENDCAP-C study. EBioMedicine. 2019;39:265-271 pubmed publisher
    ..A retrospective analysis using bisulphite pyrosequencing of an 11 marker panel (SFRP1, SFRP2, SRP4, SRP5, WIF1, TUBB6, SOX7, APC1A, APC2, MINT1, RUNX3) in samples from 35 patients with cancer, 78 with dysplasia and 343 without ..
  3. Qadir F, Aziz M, Sari C, Ma H, Dai H, Wang X, et al. Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation. Mol Cancer. 2018;17:97 pubmed publisher
    ..derived, exosomes altered molecular programmes involved in matrix modulation (MMP9), cytoskeletal remodelling (TUBB6, FEZ1, CCT6A), viral/dsRNA-induced interferon (OAS1, IFI6), anti-inflammatory (TSC22D3), deubiquitin (OTUD1), ..
  4. Nami B, Wang Z. Genetics and Expression Profile of the Tubulin Gene Superfamily in Breast Cancer Subtypes and Its Relation to Taxane Resistance. Cancers (Basel). 2018;10: pubmed publisher
    ..i>TUBA1A, TUBA1C, TUBB and TUBB3 and downregulation of TUBB2A, TUBB2B, TUBB6, TUBB7P pseudogene, and TUBGCP2 in the tumor tissues compared to the normal breast tissues...
  5. Pisanic T, Cope L, Lin S, Yen T, Athamanolap P, Asaka R, et al. Methylomic Analysis of Ovarian Cancers Identifies Tumor-Specific Alterations Readily Detectable in Early Precursor Lesions. Clin Cancer Res. 2018;24:6536-6547 pubmed publisher
    ..A panel of the 3 top-performing genes (c17orf64, IRX2, and TUBB6) was able to perfectly discriminate HGSOC (AUC 1.0)...
  6. Phadwal K, Kurian D, Salamat M, Macrae V, Diack A, Manson J. Spermine increases acetylation of tubulins and facilitates autophagic degradation of prion aggregates. Sci Rep. 2018;8:10004 pubmed publisher
    ..that spermine facilitates selective autophagic degradation of prion aggregates by binding to microtubule protein Tubb6. This is the first report in which spermine and the pathways regulated by it are applied as a novel approach ..
  7. Watts N, Sackett D, Ward R, Miller M, Wingfield P, Stahl S, et al. HIV-1 rev depolymerizes microtubules to form stable bilayered rings. J Cell Biol. 2000;150:349-60 pubmed
    ..These results suggest that Rev may interact with MTs to induce their destabilization, a proposition consistent with the previously described disruption of MTs after HIV-1 infection. ..
  8. He M, Zhang L, Wang X, Huo L, Sun L, Feng C, et al. Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity. PLoS ONE. 2013;8:e67186 pubmed publisher
    ..Our findings suggest that Tat may regulate diverse cellular activities through binding to different proteins and that the acetylation of distinct lysine residues in Tat may modulate its interaction with various partners. ..
  9. Vande Walle L, Van Damme P, Lamkanfi M, Saelens X, Vandekerckhove J, Gevaert K, et al. Proteome-wide Identification of HtrA2/Omi Substrates. J Proteome Res. 2007;6:1006-15 pubmed
    ..Our results suggest that HtrA2/Omi has a rather narrow cleavage site preference and that cytoskeletal proteins are prime targets of this protease. ..

More Information

Publications22

  1. Mariani M, Zannoni G, Sioletic S, Sieber S, Martino C, Martinelli E, et al. Gender influences the class III and V ?-tubulin ability to predict poor outcome in colorectal cancer. Clin Cancer Res. 2012;18:2964-75 pubmed publisher
    ..To predict the outcome of therapy, we assessed the role of class III (TUBB3) and class V ?-tubulin (TUBB6) as predictive biomarkers...
  2. Mosbech A, Gibbs Seymour I, Kagias K, Thorslund T, Beli P, Povlsen L, et al. DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. Nat Struct Mol Biol. 2012;19:1084-92 pubmed publisher
    ..Our findings establish DVC1 as a DNA damage-targeting p97 adaptor that protects cells from deleterious consequences of replication blocks and suggest an important role of p97 in ubiquitin-dependent regulation of TLS...
  3. Verdier Pinard P, Shahabi S, Wang F, Burd B, Xiao H, Goldberg G, et al. Detection of human betaV-tubulin expression in epithelial cancer cell lines by tubulin proteomics. Biochemistry. 2005;44:15858-70 pubmed
    ..Therefore, both betaIII- and betaV-tubulin expression levels should be systematically determined to assess the role of differential tubulin isotype expression in the response of tumors to drugs targeting microtubules. ..
  4. Law B, Spain V, Leinster V, Chia R, Beilina A, Cho H, et al. A direct interaction between leucine-rich repeat kinase 2 and specific ?-tubulin isoforms regulates tubulin acetylation. J Biol Chem. 2014;289:895-908 pubmed publisher
    ..LRRK2 selectively interacts with three ?-tubulin isoforms: TUBB, TUBB4, and TUBB6, one of which (TUBB4) is mutated in the movement disorder dystonia type 4 (DYT4)...
  5. Gigot D, Caplier I, Strosberg D, Pierard A, Glansdorff N. Amino-proximal sequences of the argF and argI ornithine carbamoyltransferases from Escherichia coli K-12 [proceedings]. Arch Int Physiol Biochim. 1978;86:913-5 pubmed
  6. Salinas R, Ogohara C, Thomas M, Shukla K, Miller S, Ko D. A cellular genome-wide association study reveals human variation in microtubule stability and a role in inflammatory cell death. Mol Biol Cell. 2014;25:76-86 pubmed publisher
    ..polymorphism on chromosome 18 is associated with decreased pyroptosis and increased expression of TUBB6 (tubulin, ? 6 class V)...
  7. Chen D, Wang M, Zhou S, Zhou Q. HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim. EMBO J. 2002;21:6801-10 pubmed
    ..Our findings reveal a strategy by which Tat induces apoptosis by targeting the microtubule network. Thus HIV-1 Tat joins a growing list of pathogen-derived proteins that target the cytoskeleton of host cells. ..
  8. Leandro García L, Leskela S, Landa I, Montero Conde C, López Jiménez E, Leton R, et al. Tumoral and tissue-specific expression of the major human beta-tubulin isotypes. Cytoskeleton (Hoboken). 2010;67:214-23 pubmed publisher
    ..In the nontumoral tissues, we found that, overall, TUBB (I), TUBB2C (IVb), and TUBB6 (V) were ubiquitous, TUBB1(VI) was hematopoietic cell-specific, and TUBB2A (IIa), TUBB2B (IIb), TUBB3 (III), and ..
  9. Chao S, Wang Y, Verdier Pinard P, Yang C, Liu L, Rodriguez Gabin A, et al. Characterization of a human ?V-tubulin antibody and expression of this isotype in normal and malignant human tissue. Cytoskeleton (Hoboken). 2012;69:566-76 pubmed publisher
    ..Thus, ?V-tubulin expression is a potentially promising prognostic marker of malignancy. ..
  10. Fazeli W, Herkenrath P, Stiller B, Neugebauer A, Fricke J, Lang Roth R, et al. A TUBB6 mutation is associated with autosomal dominant non-progressive congenital facial palsy, bilateral ptosis and velopharyngeal dysfunction. Hum Mol Genet. 2017;26:4055-4066 pubmed publisher
    ..In a five-generation pedigree, we identified a heterozygous mutation of TUBB6, a gene encoding a class V tubulin which has not been linked to a human hereditary disease so far...
  11. Campbell G, Pasquier E, Watkins J, Bourgarel Rey V, Peyrot V, Esquieu D, et al. The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis. J Biol Chem. 2004;279:48197-204 pubmed
    ..The glutamine-rich region of Tat appears to be involved in the Tat-mediated apoptosis of T-cells. ..
  12. Cucchiarelli V, Hiser L, Smith H, Frankfurter A, Spano A, Correia J, et al. Beta-tubulin isotype classes II and V expression patterns in nonsmall cell lung carcinomas. Cell Motil Cytoskeleton. 2008;65:675-85 pubmed publisher
    ..Furthermore, the ratio of MAP4 to stathmin mRNA was found to be higher in diseased lung tissues compared to normal lung tissues, suggesting this ratio might also be used as a clinically relevant biomarker for NSCLCs. ..
  13. Xu W, Liu L, Hornby D. c-IAP1 binds and processes PCSK9 protein: linking the c-IAP1 in a TNF-α pathway to PCSK9-mediated LDLR degradation pathway. Molecules. 2012;17:12086-101 pubmed publisher
    ..The novel pathway described here will open new avenues for exploring novel disease treatments. ..