TUBB3

Summary

Gene Symbol: TUBB3
Description: tubulin beta 3 class III
Alias: CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4, beta-4, tubulin beta-3 chain, class III beta-tubulin, tubulin beta-4 chain, tubulin beta-III, tubulin, beta 3
Species: human

Top Publications

  1. ncbi Expression pattern of the cell adhesion molecules. E-cadherin, P-cadherin and alpha 6 beta 4 intergrin is altered in pre-malignant skin tumors of p53-deficient mice
    A Cano
    Department of Bioquimica, Universidad Autonoma de Madrid, Spain
    Int J Cancer 65:254-62. 1996
  2. ncbi The melanocortin-1 receptor and human pigmentation
    Z Abdel-Malek
    Department of Dermatology, University of Cincinnati, Ohio 45267, USA
    Ann N Y Acad Sci 885:117-33. 1999
  3. ncbi Homologous regulation of melanocortin-1 receptor (MC1R) expression in melanoma tumor cells in vivo
    Sylvie Froidevaux
    Laboratory of Endocrinology, Department of Research, University Hospital and University Children s Hospital, CH 4031 Basel, Switzerland
    J Recept Signal Transduct Res 22:111-21. 2002
  4. ncbi The genetics of susceptibility to cutaneous melanoma
    Julia A Newton Bishop
    Division of Genetic Epidemiology, Cancer Research UK, St James s Hospital, Leeds, UK
    Drugs Today (Barc) 41:193-203. 2005
  5. doi Glycosylated DOTA-alpha-melanocyte-stimulating hormone analogues for melanoma targeting: influence of the site of glycosylation on in vivo biodistribution
    Jean Philippe Bapst
    Labor Department of Biomedicine, University Children s Hospital, Basel, Switzerland
    Bioconjug Chem 20:984-93. 2009
  6. pmc Hepatitis C virus core protein induces neuroimmune activation and potentiates Human Immunodeficiency Virus-1 neurotoxicity
    Pornpun Vivithanaporn
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 5:e12856. 2010
  7. doi The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells
    Yoshinori Sato
    Molecular Cellular Biology Laboratory, Yokohama City University Graduate School of Medical Life Science, 1 7 29 Suehirocho, Tsurumi, Yokohama 230 0045, Japan
    J Cell Sci 126:4671-83. 2013
  8. pmc Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and spread of human immunodeficiency virus type 1
    Clare Jolly
    The Sir William Dunn School of Pathology, The University of Oxford, Oxford OX1 3RE, United Kingdom
    J Virol 81:5547-60. 2007
  9. pmc HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim
    Dan Chen
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3206, USA
    EMBO J 21:6801-10. 2002
  10. ncbi The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis
    Grant R Campbell
    CNRS Formation de Recherche en Evolution 2737, Faculte de Pharmacie, Universite de la Mediterranee, 27, Boulevard Jean Moulin, 13385 Marseille, France
    J Biol Chem 279:48197-204. 2004

Research Grants

  1. David E Fisher; Fiscal Year: 2016
  2. Impact of MC1R Functional Variants on the DNA Damage Response of Human Melanocyte
    SANCY ANN LEACHMAN; Fiscal Year: 2013
  3. John A D'Orazio; Fiscal Year: 2016
  4. Coleus forskohlii extract: melanization and UV protection by a natural product
    JOHN DORAZIO; Fiscal Year: 2009
  5. Multimeric Ligands for Targeting Melanoma
    David L Morse; Fiscal Year: 2012
  6. Regressive evolution of pigmentation in the Mexican cavefish, Astyanax mexicanus
    Jessica A Lehoczky; Fiscal Year: 2010
  7. Endogenous G-Protein Coupled Receptor Antagonists
    Carrie Haskell-Luevano; Fiscal Year: 2012
  8. ATF2 in melanoma development and progression
    ZE apos EV A RONAI; Fiscal Year: 2012
  9. SIGNALING PATHWAYS FOR UV-INDUCED MELANOGENIC RESPONSE
    Zalfa Abdel-Malek; Fiscal Year: 2012
  10. A new approach to identify rare genetic variants influencing melanoma risk
    Fabienne Lesueur; Fiscal Year: 2013

Detail Information

Publications245 found, 100 shown here

  1. ncbi Expression pattern of the cell adhesion molecules. E-cadherin, P-cadherin and alpha 6 beta 4 intergrin is altered in pre-malignant skin tumors of p53-deficient mice
    A Cano
    Department of Bioquimica, Universidad Autonoma de Madrid, Spain
    Int J Cancer 65:254-62. 1996
    Expression of the cell adhesion molecules E-cadherin, P-cadherin and alpha 6 beta 4 integrin and of the keratin K13 has been analyzed in chemically induced benign skin papillomas with genetically pre-determined risks for malignant ..
  2. ncbi The melanocortin-1 receptor and human pigmentation
    Z Abdel-Malek
    Department of Dermatology, University of Cincinnati, Ohio 45267, USA
    Ann N Y Acad Sci 885:117-33. 1999
    ....
  3. ncbi Homologous regulation of melanocortin-1 receptor (MC1R) expression in melanoma tumor cells in vivo
    Sylvie Froidevaux
    Laboratory of Endocrinology, Department of Research, University Hospital and University Children s Hospital, CH 4031 Basel, Switzerland
    J Recept Signal Transduct Res 22:111-21. 2002
    ..These results demonstrate the importance of in vivo receptor regulation studies, in particular in view of the potential use of MC1R as a target for melanoma therapy...
  4. ncbi The genetics of susceptibility to cutaneous melanoma
    Julia A Newton Bishop
    Division of Genetic Epidemiology, Cancer Research UK, St James s Hospital, Leeds, UK
    Drugs Today (Barc) 41:193-203. 2005
    ..There is evidence of one at 1p22. The Melanoma Genetics Consortium (www.genomel.org) continues to explore this and the genetic epidemiology of the CDKN2A locus...
  5. doi Glycosylated DOTA-alpha-melanocyte-stimulating hormone analogues for melanoma targeting: influence of the site of glycosylation on in vivo biodistribution
    Jean Philippe Bapst
    Labor Department of Biomedicine, University Children s Hospital, Basel, Switzerland
    Bioconjug Chem 20:984-93. 2009
    ..34) by a factor of about 1.2 as compared to the parent DOTA-NAPamide (4-48 h AUC of 1.11), thus serving as new lead compound for MC1R-targeting molecules...
  6. pmc Hepatitis C virus core protein induces neuroimmune activation and potentiates Human Immunodeficiency Virus-1 neurotoxicity
    Pornpun Vivithanaporn
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 5:e12856. 2010
    ..Herein, we investigate HCV infectivity and effects on neuronal survival and neuroinflammation in conjunction with HIV infection...
  7. doi The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells
    Yoshinori Sato
    Molecular Cellular Biology Laboratory, Yokohama City University Graduate School of Medical Life Science, 1 7 29 Suehirocho, Tsurumi, Yokohama 230 0045, Japan
    J Cell Sci 126:4671-83. 2013
    ....
  8. pmc Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and spread of human immunodeficiency virus type 1
    Clare Jolly
    The Sir William Dunn School of Pathology, The University of Oxford, Oxford OX1 3RE, United Kingdom
    J Virol 81:5547-60. 2007
    ..Based on these data, we propose that HIV-1 requires both actin and tubulin components of the T-cell cytoskeleton to direct its assembly and budding and to elaborate a functional VS...
  9. pmc HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim
    Dan Chen
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3206, USA
    EMBO J 21:6801-10. 2002
    ..Our findings reveal a strategy by which Tat induces apoptosis by targeting the microtubule network. Thus HIV-1 Tat joins a growing list of pathogen-derived proteins that target the cytoskeleton of host cells...
  10. ncbi The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis
    Grant R Campbell
    CNRS Formation de Recherche en Evolution 2737, Faculte de Pharmacie, Universite de la Mediterranee, 27, Boulevard Jean Moulin, 13385 Marseille, France
    J Biol Chem 279:48197-204. 2004
    ..The glutamine-rich region of Tat appears to be involved in the Tat-mediated apoptosis of T-cells...
  11. ncbi Class III beta-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients
    Simona Mozzetti
    Laboratory of Antineoplastic Pharmacology, Universita Cattolica Sacro Cuore, Rome, Italy
    Clin Cancer Res 11:298-305. 2005
    ..By a direct comparison of the three main known mechanisms of paclitaxel resistance, this study indicates that overexpression of class III beta-tubulin is the most prominent mechanism of paclitaxel resistance in ovarian cancer...
  12. ncbi Expression of class III {beta}-tubulin is predictive of patient outcome in patients with non-small cell lung cancer receiving vinorelbine-based chemotherapy
    Pascal Seve
    Service de Medecine Interne, Hotel Dieu, Hospices Civils de Lyon, Lyon, France
    Clin Cancer Res 11:5481-6. 2005
    ..To determine the prevalence and the prognostic value of microtubule component expression in tumors of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)...
  13. ncbi Class III beta-tubulin overexpression is a marker of poor clinical outcome in advanced ovarian cancer patients
    Gabriella Ferrandina
    Department of Oncology, Catholic University, Campobasso, Italy
    Clin Cancer Res 12:2774-9. 2006
    ..We also investigated whether beta III tubulin expression could be modified after the selective pressure represented by chemotherapy in vivo...
  14. doi Hypoxia induces class III beta-tubulin gene expression by HIF-1alpha binding to its 3' flanking region
    Giuseppina Raspaglio
    Department of Oncology, Catholic University of the Sacred Heart, Campobasso, Italy
    Gene 409:100-8. 2008
    Class III beta-tubulin (TUBB3) overexpression represents a major mechanism of drug resistance to microtubule interacting agents such as taxanes and Vinca alkaloids. Here, we tested hypoxia as a possible inducer of TUBB3...
  15. doi Expression of ERCC1 and class IIIbeta tubulin for predicting effect of carboplatin/paclitaxel in patients with advanced inoperable non-small cell lung cancer
    Satoshi Ikeda
    Department of Pathology, Tsuchiura Kyodo General Hospital, Ibaraki, Japan
    Pathol Int 59:863-7. 2009
    ..485; 95% confidence interval: 1.123-10.818, P= 0.031). It was concluded that determination of the expression of these proteins is useful to predict the effects of platinum-based anticancer drugs...
  16. doi [The correlation between chemotherapeutic efficacy and breast cancer susceptibility gene 1 and class IIIβ-tubulin protein expression in non-small cell lung cancer patients]
    Yi Yuan Wan
    Department of Medical Oncology, the First Hospital of Huai an City Affiliated Nanjing Medical College, Jiangsu Province, Huai an, China
    Zhonghua Nei Ke Za Zhi 50:469-73. 2011
    ....
  17. doi The role of βIII-tubulin in non-small cell lung cancer patients treated by taxane-based chemotherapy
    Kyoichi Kaira
    Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi cho, Sunto gun, Shizuoka, 411 8777, Japan
    Int J Clin Oncol 18:371-9. 2013
    The aim of this study is to evaluate whether class III β-tubulin (TUBB3) expression could predict progression-free survival or overall survival in relapsed non-small cell lung cancer (NSCLC) patients treated with taxene-based ..
  18. pmc HIV-1 rev depolymerizes microtubules to form stable bilayered rings
    N R Watts
    Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    J Cell Biol 150:349-60. 2000
    ..These results suggest that Rev may interact with MTs to induce their destabilization, a proposition consistent with the previously described disruption of MTs after HIV-1 infection...
  19. ncbi Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer
    Rafael Rosell
    Department of Oncology, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
    Oncogene 22:3548-53. 2003
    ..The predictive value of beta-tubulin III, stathmin and RRM1 should be tested in prospective customized chemotherapy trials, the results of which will help tailor chemotherapy to improve patient survival...
  20. pmc HIV-1 Tat protein enhances microtubule polymerization
    Jean de Mareuil
    UMR Univ, Med, CNRS FRE 2737, Faculte de Pharmacie, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille, France
    Retrovirology 2:5. 2005
    ..We compared the effect on tubulin polymerization of these Tat variants and peptides corresponding to different parts of the Tat sequence, with paclitaxel, an anti-cancer drug that targets microtubules...
  21. pmc HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?
    Mauro Giacca
    Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    Retrovirology 2:7. 2005
    ..Two papers now published in Retrovirology provide possible molecular mechanisms for the pro-apoptotic effect of Tat, which involve the cell's microtubular network and the mitochondrial pathway of apoptosis...
  22. ncbi Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression
    Mayte Coiras
    AIDS Immunopathology Unit, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    Proteomics 6:S63-73. 2006
    ..In conclusion, in addition to its role in viral mRNA elongation, the proteomic approach has provided insight into the way that Tat modifies host cell gene expression...
  23. ncbi Class III beta-tubulin expression and benefit from adjuvant cisplatin/vinorelbine chemotherapy in operable non-small cell lung cancer: analysis of NCIC JBR.10
    Pascal Seve
    Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada
    Clin Cancer Res 13:994-9. 2007
    ..We sought to determine the effect of bTubIII on patient outcome and benefit from adjuvant chemotherapy in the JBR.10 trial...
  24. pmc Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat
    Caroline Egelé
    Universite Louis Pasteur, Strasbourg 1, Institut Gilbert Laustriat, CNRS, UMR 7175, Département Photophysique des Interactions Biomoléculaires, Illkirch, Cedex, France
    Retrovirology 5:62. 2008
    ..Tat binds two Zn2+ ions through its conserved cysteine-rich region in vitro, but the role of zinc in the structure and properties of Tat is still controversial...
  25. doi Expression of ERCC1 and class III beta-tubulin in non-small cell lung cancer patients treated with carboplatin and paclitaxel
    Koichi Azuma
    Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Lung Cancer 64:326-33. 2009
    ....
  26. doi Expression of excision repair cross-complementation group 1, breast cancer susceptibility 1, and β III-tubulin in thymic epithelial tumors
    Kyoichi Kaira
    Division of Thoracic Oncology, Shizuoka Cancer Center, Sunto gun, Shizuoka, Japan
    J Thorac Oncol 6:606-13. 2011
    We investigated the clinical significance of excision repair cross-complementation group 1 (ERCC1), breast cancer susceptibility 1 (BRCA1), and class III β-tubulin (TUBB3) expression in thymic epithelial tumors.
  27. ncbi The functions of laminins: lessons from in vivo studies
    M C Ryan
    Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Matrix Biol 15:369-81. 1996
    ..Current evidence supports this view, as the absence of integrin alpha 6 beta 4 (Vidal et al., 1995; Dowling et al., 1996; Georges-Labouesse et al., 1996; van der Neut et al...
  28. ncbi The tympanic membrane: a biochemical updating of structural components
    D Broekaert
    Laboratory of Physiological Chemistry, University of Ghent, Belgium
    Acta Otorhinolaryngol Belg 49:127-37. 1995
    ..be associated with intermediate filaments, and the transmembrane components in the dense plaque (BPAG2 and alpha 6 beta 4 integrin), whose extracellular domains directly interact with basement membrane components...
  29. pmc Validity of (-)-[3H]-CGP 12177A as a radioligand for the 'putative beta4-adrenoceptor' in rat atrium
    D Sarsero
    Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia
    Br J Pharmacol 123:371-80. 1998
    ..4. The catecholamines competed with (-)-[3H]-CGP 12177A at the 'putative beta 4-adrenoceptor' in a stereoselective manner, (-)-noradrenaline (pKiH 6.3+/-0.3, pKiL 3.5+/-0...
  30. ncbi Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes
    L E Chavez-Noriega
    SIBIA Neurosciences, Inc, La Jolla, California, USA
    J Pharmacol Exp Ther 280:346-56. 1997
    Human neuronal nicotinic acetylcholine receptors (nAChRs) h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 were expressed in Xenopus oocytes and tested for their ..
  31. ncbi The synthesis of no-carrier-added DL-4-[18F]fluorodeprenyl via the nucleophilic aromatic substitution reaction
    A Plenevaux
    Liege University, Cyclotron Research Center, Belgium
    Int J Rad Appl Instrum A 42:121-7. 1991
    ..Clearance of radioactivity from brain after injection of DL-4-[18F]fluorodeprenyl was more rapid than that previously observed for [11C]L-deprenyl...
  32. pmc Crucial role of the melanocortin receptor MC1R in experimental colitis
    C Maaser
    Department of Medicine B, University of Munster, Albert Schweitzer Str 33, D 48129 Munster, Germany
    Gut 55:1415-22. 2006
    ..The aim of this study was therefore to determine whether a breakdown of the alpha MSH-MC1R pathway leads to worsening of disease...
  33. ncbi A gallium-labeled DOTA-alpha-melanocyte- stimulating hormone analog for PET imaging of melanoma metastases
    Sylvie Froidevaux
    Laboratory of Endocrinology, Department of Research, University Hospital and University Children s Hospital, Basel, Switzerland
    J Nucl Med 45:116-23. 2004
    ..The aim of this study was to develop a positron emitter-labeled alpha-MSH analog suitable for PET imaging of melanoma metastases...
  34. ncbi Polymerisation of chemically cross-linked actin:thymosin beta(4) complex to filamentous actin: alteration in helical parameters and visualisation of thymosin beta(4) binding on F-actin
    Edda Ballweber
    Department of Anatomy and Cell Biology, Ruhr University, Bochum, Germany
    J Mol Biol 315:613-25. 2002
    ..However, parts of the difference map might represent subtle conformational changes of both proteins occurring upon complex formation...
  35. ncbi Minimization of MC1R selectivity by modification of the core structure of alpha-MSH-ND
    S Lim
    Division of Endocrinology, Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, South Korea
    Chem Biol 8:857-70. 2001
    ....
  36. ncbi Mesothelial cells in suspension expose an enriched integrin repertoire capable of capturing soluble fibronectin and laminin
    Thomas F E Barth
    Institute of Pathology, Ulm University, Ulm, Germany
    Cell Commun Adhes 9:1-14. 2002
    ..The distribution of beta 1-, beta 3-, beta 4-integrins and fibronectin and laminin in normal and chronically inflamed pleura and in/on MC from pleural ..
  37. ncbi Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord
    E Hellström-Lindahl
    Department of Clinical Neuroscience and Family Medicine, Karolinska Institutet, Huddinge University Hospital, Sweden
    Brain Res Dev Brain Res 108:147-60. 1998
    ..Expression of alpha 3, alpha 4, alpha 5, alpha 7, beta 2, beta 3 and beta 4 mRNA were all detected in the prenatal spinal cord, medulla oblongata, pons, cerebellum, mesencephalon, ..
  38. doi Curcumin inhibition of integrin (alpha6beta4)-dependent breast cancer cell motility and invasion
    Hong Im Kim
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Cancer Prev Res (Phila) 1:385-91. 2008
    ....
  39. ncbi A novel DOTA-alpha-melanocyte-stimulating hormone analog for metastatic melanoma diagnosis
    Sylvie Froidevaux
    Laboratory of Endocrinology, Department of Research, University Hospital and University Children s Hospital, Basel, Switzerland
    J Nucl Med 43:1699-706. 2002
    ..The aim of this study was to develop a melanoma-selective radiolabeled alpha-MSH analog suitable for melanoma diagnosis...
  40. pmc Thymosin beta(4) and beta(10) levels in pre-term newborn oral cavity and foetal salivary glands evidence a switch of secretion during foetal development
    Sonia Nemolato
    Dipartimento di Citomorfologia, Universita di Cagliari, Cagliari, Italy
    PLoS ONE 4:e5109. 2009
    ..Thymosin beta(4), its sulfoxide, and thymosin beta(10) were detected in whole saliva of human pre-term newborns by reversed-phase high performance chromatography coupled to electrospray ion-trap mass spectrometry...
  41. ncbi Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines
    M E Hemler
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 264:6529-35. 1989
    ..colon carcinoma cell lines and other epithelial cells the alpha 6 subunit associates with a novel protein (called beta 4) rather than the VLA beta 1 subunit...
  42. ncbi Adhesive and proteolytic phenotype of migrating endothelial cells induced by thymosin beta-4
    Czeslaw S Cierniewski
    Department of Molecular and Medical Biophysics, Medical University, 6 8 Mazowiecka Street, Lodz 92 215, Poland
    Ann N Y Acad Sci 1112:123-39. 2007
    ....
  43. ncbi Identification of cross-reactive T cell restriction epitopes located on the DR7 beta 1 and DR beta 4 molecules
    G Bismuth
    Laboratoire d Immunologie Cellulaire et Tissulaire, CNRS UA 186, , Paris, France
    Hum Immunol 28:271-83. 1990
    ..Both the DR alpha:DR7 beta 1 and DR alpha:DR beta 4 (DR omega 53) molecules of the DR7 allotype serve as restriction elements for the diphtheria toxoid-specific T-..
  44. pmc Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo
    M M Ollmann
    Department of Pediatrics, and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5428, USA
    Genes Dev 12:316-30. 1998
    ....
  45. ncbi Effect of two thymosin fraction 5 polypeptides on human peripheral blood lymphocytes
    D Kokkinopoulos
    Laboratory of Immunobiology, Hellenic Anticancer Institute, Athens, Greece
    Immunopharmacol Immunotoxicol 9:409-19. 1987
    Thymosin fraction 5 polypeptides beta 4 and alpha 1 were tested for their ability to affect certain immunological parameters of human peripheral blood lymphocytes (PBL)...
  46. ncbi Association of MC1R variants and risk of melanoma in melanoma-prone families with CDKN2A mutations
    Alisa M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
    Cancer Epidemiol Biomarkers Prev 14:2208-12. 2005
    ..Additional studies are needed to confirm these findings and to explore the mechanisms that may contribute to this relationship...
  47. ncbi Contribution of melanocortin-1 receptor gene variants to sporadic cutaneous melanoma risk in a population in central Italy: a case-control study
    Maria Concetta Fargnoli
    Departments of Dermatology, University of L Aquila, L Aquila, Italy
    Melanoma Res 16:175-82. 2006
    ..These results support the contribution of high-penetrance MC1R variant alleles to genetic predisposition to sporadic cutaneous melanoma in a population in central Italy...
  48. ncbi [D-Trp8]-gamma-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse)
    Stephen J Getting
    The William Harvey Research Institute, Charterhouse Square, London, United Kingdom
    Mol Pharmacol 70:1850-5. 2006
    ....
  49. pmc Distinct pigmentary and melanocortin 1 receptor-dependent components of cutaneous defense against ultraviolet radiation
    Craig S April
    Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 3:e9. 2007
    ....
  50. pmc Small-animal PET of melanocortin 1 receptor expression using a 18F-labeled alpha-melanocyte-stimulating hormone analog
    Zhen Cheng
    Molecular Imaging Program at Stanford, Stanford University, Stanford, California 94305, USA
    J Nucl Med 48:987-94. 2007
    ..It is a promising molecular target for diagnosis and therapy of melanomas. However, (18)F compounds have not been successfully developed for imaging the MC1R...
  51. ncbi The subcellular distribution of the high molecular mass protein, HD1, is determined by the cytoplasmic domain of the integrin beta 4 subunit
    P Sánchez-Aparicio
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Cell Sci 110:169-78. 1997
    ..possess HD1 but not BP230 or BP180; two other hemidesmosomal constituents, and express only traces of the alpha 6 beta 4 integrin...
  52. ncbi DNA polymorphism and selection at the melanocortin-1 receptor gene in normally pigmented southern African individuals
    Premila R John
    Department of Human Genetics, School of Pathology, National Health Laboratory Service and University of the Witwatersrand, Johannesburg 2000, South Africa
    Ann N Y Acad Sci 994:299-306. 2003
    ....
  53. ncbi Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival
    S M Smits
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Neuroscience 136:171-9. 2005
    ..The mGluR1-signaling downstream-effector phospholipase C beta 4 was identified in a suppression subtractive hybridization screen comparing wild-type and Pit x 3-deficient Aphakia ..
  54. ncbi Melanocortin-1 receptor (MC1R) gene variants and dysplastic nevi modify penetrance of CDKN2A mutations in French melanoma-prone pedigrees
    Valerie Chaudru
    Institut National de la Sante et de la Recherche Medicale, Université d Evry, EMI 0006, Tour Evry 2, 523 Place des Terrasses de l Agora, 91034 Evry, France
    Cancer Epidemiol Biomarkers Prev 14:2384-90. 2005
    ..21; P = 0.03] and dysplastic nevi (OR, 2.93; P < 0.01). Such results may have important consequences to improve the prediction of melanoma risk in families...
  55. ncbi Melanocytes expressing MC1R polymorphisms associated with red hair color have altered MSH-ligand activated pigmentary responses in coculture with keratinocytes
    Donald W Roberts
    Melanogenix Group, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
    J Cell Physiol 215:344-55. 2008
    ....
  56. doi Class III beta-tubulin shows unique expression patterns in a variety of neoplastic and non-neoplastic lymphoproliferative disorders
    Sun Och Yoon
    Department of Pathology, Seoul National University Hospital, Seoul, Korea
    Am J Surg Pathol 34:645-55. 2010
    Class III beta-tubulin (TUBB3) expression in carcinoma is associated with resistance to tubulin-binding chemotherapeutic agents. Recently, follicular dendritic cells (FDCs) were reported to express TUBB3 under physiologic conditions...
  57. ncbi Flavonoids and terpenoids from Luma gayana (Barn.) Burret
    G A Wächter
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson 85721, USA
    Z Naturforsch C 54:1140-2. 1999
    ..Burret. This is the first report on the chemistry of this species...
  58. doi A retro-inverso α-melanocyte stimulating hormone analog with MC1R-binding selectivity
    Timothy Weeden
    Transplant and Immunology Research, 49 New York Avenue, Framingham, MA 01701, USA
    J Pept Sci 17:47-55. 2011
    ..A number of other structural modifications of the RI peptide were found to differ in effect from those reported for the L-form α-MSH, suggesting a significantly altered interaction with the MC1R...
  59. ncbi Subcellular distribution of thymosin beta4
    Robert E Zoubek
    Institute of Biochemistry, University Erlangen Nuremberg, Fahrstr 17, Erlangen, Germany
    Ann N Y Acad Sci 1112:442-50. 2007
    ..A passive but regulated diffusion could explain the described ability of thymosin beta(4) to shuttle into the nucleus...
  60. ncbi Alpha 6 beta 4 and alpha 6 beta 1 integrins associate with ErbB-2 in human carcinoma cell lines
    R Falcioni
    Laboratorio Oncogenesi Molecolare, Istituto Regina Elena, Centro Ricerca Sperimentale, Rome, Italy
    Exp Cell Res 236:76-85. 1997
    ..analyses of purified immune complexes, we studied the association of laminin receptors (alpha 6 beta 1 and alpha 6 beta 4) with ErbB-2 tyrosine kinase in human carcinoma cell lines...
  61. ncbi Epidermolysis bullosa with congenital pyloric atresia: novel mutations in the beta 4 integrin gene (ITGB4) and genotype/phenotype correlations
    A Nakano
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Pediatr Res 49:618-26. 2001
    ..Mutations in the genes encoding subunit polypeptides of the alpha 6 beta 4 integrin (ITGA6 and ITGB4) have been demonstrated in EB-PA patients...
  62. ncbi Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains
    Q A Yuan
    Department of Molecular Medicine, School of Medicine, University of Auckland, New Zealand
    Int Immunol 2:1097-108. 1990
    ..The recent discovery of beta 4 and beta 5 subunits, and the sharing of alpha subunits between beta subfamilies reflects a greater structural and ..
  63. ncbi Genomic organization of the integrin beta 4 gene (ITGB4): a homozygous splice-site mutation in a patient with junctional epidermolysis bullosa associated with pyloric atresia
    L Pulkkinen
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Lab Invest 76:823-33. 1997
    Integrin beta 4 is expressed primarily within the epithelial basement membranes, and it contributes to the stable association of epidermis with the underlying basement membrane...
  64. pmc Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival
    J Dowling
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA
    J Cell Biol 134:559-72. 1996
    The integrin heterodimer alpha 6 beta 4 is expressed in many epithelia and in Schwann cells...
  65. ncbi Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins
    Y Kikkawa
    Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi, Osaka 594 1101, Japan
    J Cell Sci 113:869-76. 2000
    ..K562 cells transfected with alpha 6 and beta 4 subunits were also capable of adhering to laminin-10/11, indicating that integrin alpha 6 beta 4 is another ..
  66. pmc Melanocortin-1 receptor gene variants determine the risk of nonmelanoma skin cancer independently of fair skin and red hair
    M T Bastiaens
    Department of Dermatology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Am J Hum Genet 68:884-94. 2001
    ..These findings indicate that MC1R gene variants are important independent risk factors for nonmelanoma skin cancer...
  67. ncbi Deficiency of nicotinic acetylcholine receptor beta 4 subunit causes autonomic cardiac and intestinal dysfunction
    Ningshan Wang
    Department of Physiology and Pharmacology, Sackler Medical School, Genetic Institute, Tel Aviv University, Ramat Aviv, Israel
    Mol Pharmacol 63:574-80. 2003
    Neuronal nicotinic acetylcholine receptors (nAChR) are composed of 12 subunits (alpha 2-alpha 10 and beta 2-beta 4), which play the central role in autonomic transmission...
  68. ncbi MC1R, ASIP, and DNA repair in sporadic and familial melanoma in a Mediterranean population
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7236, USA
    J Natl Cancer Inst 97:998-1007. 2005
    ..We examined MC1R and ASIP genotypes in relation to phenotypic characteristics, sporadic and familial melanoma risk, and melanoma thickness as an indicator of disease progression in a Mediterranean population...
  69. pmc Diminishment of alpha-MSH anti-inflammatory activity in MC1r siRNA-transfected RAW264.7 macrophages
    Dayu Li
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    J Leukoc Biol 84:191-8. 2008
    ..The results imply that although all of the MCr are G-coupled proteins, they may not necessarily function through the same intracellular pathways in macrophages...
  70. ncbi Thymosin beta 4Xen: a new thymosin beta 4-like peptide in oocytes of Xenopus laevis
    E Hannappel
    Abteilung für Physikalische Biochemie, Universitat Tubingen, West Germany
    Arch Biochem Biophys 260:546-51. 1988
    Two new thymosin beta 4-like peptides have been detected in ovaries of Xenopus laevis and Rana esculenta. Previously, it was reported that thymosin beta 4 can be found in various species, from mammals to amphibians, e.g., in X. laevis [S...
  71. ncbi Structure of the C-terminal RNA-binding domain of hnRNP D0 (AUF1), its interactions with RNA and DNA, and change in backbone dynamics upon complex formation with DNA
    M Katahira
    Department of Environment and Natural Sciences, Graduate School of Environment and Information Sciences, 79 7 Tokiwadai, Hodogaya ku, Yokohama, 240 8501, Japan
    J Mol Biol 311:973-88. 2001
    ..In addition to the four beta-strands commonly found in RNP-type RBDs, an extra beta-strand, termed beta 4(-), was found just before the fourth beta-strand, yielding a five-stranded beta-sheet...
  72. ncbi Differential localization of laminin gamma and integrin beta in primary cultures of the rat gingival epithelium
    Michie Tanno
    Department of Periodontics, Tokyo Dental College, Chiba, Japan
    J Periodontal Res 41:15-22. 2006
    ..The aim of this study was to investigate the differential immunolocalization of laminin gamma(2) and integrin beta(4) in primary cultures of the rat gingival epithelium...
  73. ncbi High diversity in functional properties of melanocortin 1 receptor (MC1R) in divergent primate species is more strongly associated with phylogeny than coat color
    Tatjana Haitina
    Department of Neuroscience, Division of Pharmacology, Biomedical Center, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 24:2001-8. 2007
    ..This diversity of function is broadly associated with primate phylogeny and does not have a simple relation to coat color phenotype within primate clades...
  74. ncbi Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy
    G Smith
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Br J Dermatol 157:1230-4. 2007
    ..Inheritance of various MC1R alleles has been associated with a red hair/fair skin phenotype, increased incidence of skin cancer and altered sensitivity to ultraviolet (UV) radiation...
  75. ncbi [Acid-base equilibrium of hydrazone derivatives 4-R-3R1-thazol-2-one. I. Ionization constants of alpha-methyl-beta-(4-R-thiazol-2-yl)- and alpha-methyl-beta-(4-R-3-R1-thiazol-2-ylidene)-hydrazides of benzoic acid]
    L Bielak
    , Akademia Medyczna w Lublinie
    Ann Univ Mariae Curie Sklodowska Med 47:5-14. 1992
    ....
  76. ncbi Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation
    M Cathy Scott
    Department of Dermatology, University of Cincinnati College of Medicine, PO Box 670592, Cincinnati, Ohio 45267 0592, USA
    J Cell Sci 115:2349-55. 2002
    ..We conclude that loss-of-function mutations in the MC1R gene sensitize human melanocytes to the DNA damaging effects of UV radiation, which may increase skin cancer risk...
  77. ncbi Adaptive reptile color variation and the evolution of the Mc1r gene
    Erica Bree Rosenblum
    Museum of Vertebrate Zoology, University of California, Berkeley, California 94720, USA
    Evolution 58:1794-808. 2004
    ..This study provides comparative data on a nuclear gene in reptiles and highlights the utility of a candidate-gene approach for understanding the evolution of genes involved in vertebrate adaptation...
  78. ncbi The eumelanin and pheomelanin contents in dorsal hairs of female recessive yellow mice are greater than in male
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Dermatol Sci 45:55-62. 2007
    ....
  79. ncbi Excess tyrosine rescues the reduced activity of proliferation and differentiation of cultured recessive yellow melanocytes derived from neonatal mouse epidermis
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Eur J Cell Biol 86:315-30. 2007
    ....
  80. ncbi Expression of thymosin beta 4 gene during Xenopus laevis embryogenesis
    M Yamamoto
    Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 184:93-9. 1992
    ..The amino acid sequence of enzymic digests showed the peptide is extremely similar to mammalian thymosin beta 4. The peptide was capable of binding actin monomers like mammalian counterparts...
  81. ncbi Homo- and heterotetrameric forms of the membrane-bound metalloendopeptidases meprin A and B
    C M Gorbea
    Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061 0308
    Arch Biochem Biophys 290:549-53. 1991
    ..C3H/He mice expressed only the 110-kDa beta subunits and the beta 4 oligomer. This type of multimeric organization of disulfide-linked subunits is unique for the known endopeptidases.
  82. ncbi Identification of a region of UDP-galactose:N-acetylglucosamine beta 4-galactosyltransferase involved in UDP-galactose binding by differential labeling
    S Yadav
    Department of Biochemistry and Molecular Biology, University of Miami, Florida 33136 1015
    J Biol Chem 265:14163-9. 1990
    The location of regions in the primary structure of UDP-galactose:N-acetylglucosamine beta 4-galactosyl-transferase (GT) that are involved in binding UDP-galactose has been investigated by differential chemical modification with two ..
  83. ncbi A proteoglycan (aggrecan)-specific T cell hybridoma induces arthritis in BALB/c mice
    E I Buzás
    Department of Biochemistry, Rush Medical University at Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Immunol 155:2679-87. 1995
    ..The PG-specific and arthritogenic T cell hybridoma (5/4E8) expressed TCR-alpha beta + (V beta 4), CD4+, and CD8- phenotypes and belonged to the Th1 subset, as the cells secreted IL-2 and IFN-gamma, but not IL-4 ..
  84. pmc Genetic enhancement of RNA-processing defects by a dominant mutation in B52, the Drosophila gene for an SR protein splicing factor
    X Peng
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Mol Cell Biol 15:6273-82. 1995
    ..of B52ED with the B52+ allele from which it was derived revealed a single change in a conserved amino acid in the beta 4 strand of the first RNA-binding domain of B52, which suggests that altered RNA binding is responsible for the ..
  85. ncbi The agouti-related protein decapeptide (Yc[CRFFNAFC]Y) possesses agonist activity at the murine melanocortin-1 receptor
    C Haskell-Luevano
    Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610, USA
    Peptides 21:683-9. 2000
    ..8) and, unexpectedly, MC1R agonist activity (EC(50) = 2.89 microM). This study characterizes the first AGRP-based peptide agonist at the melanocortin receptors...
  86. pmc Identification of key amino acids of the mouse mammary tumor virus superantigen involved in the specific interaction with T-cell receptor V(beta) domains
    F Baribaud
    Institute of Microbiology, University of Lausanne, CH 1011 Lausanne, CH 1066 Epalinges, Switzerland
    J Virol 75:7453-61. 2001
    ....
  87. ncbi Molecular cloning, genomic organization, and mapping of beta 4GalT-VIb, a brain abundant member of beta 4-galactosyltransferase gene family, to human chromosome 18q12.1
    Yuxin Fan
    State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University, 220 Handan Road, Shanghai 200433, People s Republic of China
    DNA Seq 13:1-8. 2002
    In the present study, a brain abundant member of beta 4-galactosyltransferase gene family with an open reading frame encoding 343 amino acids was cloned and identified from a human leukemia cell cDNA library...
  88. ncbi No reduction of dopamine transporter binding sites in mice following treatment with the TIQ analogue 1-benzyl-1,2,3,4-tetrahydroisoquinoline
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi, Tokyo 173 0022, Japan
    Brain Res 960:282-5. 2003
    ..p., twice per day for 10 days) induced a 14% decrease. These results indicate that 1-BnTIQ does not affect the density of DATs on dopaminergic neurons, and that it is not clear whether or not 2-methyl-TIQ is an active form of TIQ...
  89. ncbi Genetic epidemiology of melanoma
    V Bataille
    Dermatology and Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Eur J Cancer 39:1341-7. 2003
    ..For the primary and secondary prevention of this tumour, efforts need to be sustained in public health campaigns on sun exposure and the recognition of individuals at high risk...
  90. ncbi Gene structure of the goldfish agouti-signaling protein: a putative role in the dorsal-ventral pigment pattern of fish
    Jose Miguel Cerdá-Reverter
    Department of Fish Reproductive Physiology, Instituto de Acuicultura de Torre de la Sal, Consejo Superior de Investigaciones Cientificas, 12595 Torre de la Sal, Ribera de Cabanes, Castellon, Spain
    Endocrinology 146:1597-610. 2005
    ..Our studies support agouti signaling protein as the melanization inhibition factor, a key factor in the development of the dorsal-ventral pigment pattern in fish...
  91. ncbi A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats
    Hansen M Hsiung
    Division of Endocrine Research, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    Endocrinology 146:5257-66. 2005
    ....
  92. ncbi Levels of G-protein alpha q/11 subunits and of phospholipase C-beta(1-4), -gamma, and -delta1 isoforms in postmortem human brain caudate and cortical membranes: potential functional implications
    Maider López de Jesús
    Department of Pharmacology, Faculty of Pharmacy, University of the Basque Country, Spain
    Neurochem Int 49:72-9. 2006
    ....
  93. doi Patchy distributions belie morphological and genetic homogeneity in rosy-finches
    Sergei V Drovetski
    CIBIO, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Campus Agrário de Vairão, Rua Padre Armando Quintas, Crasto 4485 661 Vairão, Portugal
    Mol Phylogenet Evol 50:437-45. 2009
    ..Our analyses showed that DNA and phenotypic data are not in conflict, but rather complement each other, and together help clarify species limits. Our data are consistent with a single species in North America, not three...
  94. pmc HIV-1 Tat protein-induced rapid and reversible decrease in [3H]dopamine uptake: dissociation of [3H]dopamine uptake and [3H]2beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane (WIN 35,428) binding in rat striatal synaptosomes
    Jun Zhu
    Program in Behavioral Neuroscience, Department of Psychology, University of South Carolina, 1512 Pendleton St, Columbia, SC 29208, USA
    J Pharmacol Exp Ther 329:1071-83. 2009
    ..These findings provide new insight into understanding the pharmacological mechanisms of Tat-induced dysfunction of the DAT in the dopaminergic system in HIV-infected patients...
  95. pmc Genome-wide association study identifies three loci associated with melanoma risk
    D Timothy Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James s University Hospital, Leeds, UK
    Nat Genet 41:920-5. 2009
    ..Despite wide variation in allele frequency, these genetic variants show notable homogeneity of effect across populations of European ancestry living at different latitudes and show independent association to disease risk...
  96. doi Melanocortin 1 receptor mutations impact differentially on signalling to the cAMP and the ERK mitogen-activated protein kinase pathways
    Cecilia Herraiz
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Murcia, 30100 Espinardo, Spain
    FEBS Lett 583:3269-74. 2009
    ..Thus, the melanoma-associated MC1R mutations impact differently on cAMP and ERK signalling, suggesting that cAMP is not responsible for functional coupling of MC1R to the ERK cascade...
  97. doi Integrin receptors play a role in the internalin B-dependent entry of Listeria monocytogenes into host cells
    Clementina Auriemma
    Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici, Italy
    Cell Mol Biol Lett 15:496-506. 2010
    ..Our findings provide the first evidence that beta(3)- and beta(1)-integrin receptors play a role in the inlB-dependent internalization of L. monocytogenes into host cells...
  98. doi In vitro differentiation of human parthenogenetic stem cells into neural lineages
    Dmitry A Isaev
    International Stem Cell Corporation, Carlsbad, CA, USA
    Regen Med 7:37-45. 2012
    ..for at least 30 passages and can be spontaneously differentiated into cells with neuron morphology that express TUBB3 and MAP2, and fire action potentials...
  99. pmc MC1R is a potent regulator of PTEN after UV exposure in melanocytes
    Juxiang Cao
    Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA
    Mol Cell 51:409-22. 2013
    ..These studies establish the MC1R-PTEN axis as a central regulator for melanocytes' response to UVB exposure and reveal the molecular basis underlying the association between MC1R variants and melanomagenesis. ..
  100. doi Anti-melanogenic effects of δ-tocotrienol are associated with tyrosinase-related proteins and MAPK signaling pathway in B16 melanoma cells
    Lean Teik Ng
    Department of Agricultural Chemistry, National Taiwan University, Taipei, Taiwan
    Phytomedicine 21:978-83. 2014
    ..These data provide insight to δT3's effect and the targeting of ERK signaling for treatment against melanogenesis...
  101. pmc Functional Characterization of MC1R-TUBB3 Intergenic Splice Variants of the Human Melanocortin 1 Receptor
    Cecilia Herraiz
    Department of Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Murcia, Campus de Espinardo, Murcia and IMIB Arrixaca, El Palmar, Murcia, Spain
    PLoS ONE 10:e0144757. 2015
    ..MC1R has an inefficient poly(A) site allowing intergenic splicing with its downstream neighbour Tubulin-β-III (TUBB3)...

Research Grants63

  1. David E Fisher; Fiscal Year: 2016
    ..Collectively we extend our deep analyses of MITF biology into a translational direction that relates melanocytic homeostasis to melanomagenesis and novel prevention strategies. ! ..
  2. Impact of MC1R Functional Variants on the DNA Damage Response of Human Melanocyte
    SANCY ANN LEACHMAN; Fiscal Year: 2013
    ..These studies will improve risk assessment of melanoma susceptible individuals and development of effective strategies for melanoma prevention and early detection. ..
  3. John A D'Orazio; Fiscal Year: 2016
    ..Together, these studies will lay the foundation for future translational studies designed to develop novel small molecule-based approaches for UV and cancer protection to prevent many cases of melanoma. ..
  4. Coleus forskohlii extract: melanization and UV protection by a natural product
    JOHN DORAZIO; Fiscal Year: 2009
    ..Our proposed research includes both in vivo and in vitro analyses of UV effects in whole skin and in melanocytes derived from our animal model, respectively. ..
  5. Multimeric Ligands for Targeting Melanoma
    David L Morse; Fiscal Year: 2012
    ..They also have advantages over other multifunctional agents in that they are produced via convergent synthesis and hence are relatively small with acceptable ADME characteristics. ..
  6. Regressive evolution of pigmentation in the Mexican cavefish, Astyanax mexicanus
    Jessica A Lehoczky; Fiscal Year: 2010
    ..Regulatory mutations and dominant mutations identified from this proposal will provide sequences that could be screened in human patients, for whom no mutations have yet been identified. ..
  7. Endogenous G-Protein Coupled Receptor Antagonists
    Carrie Haskell-Luevano; Fiscal Year: 2012
    ..This research project proposes to generate knowledge for the rational design of molecules as potential therapeutic agents to prevent or treat the diseases associated with over or under eating. ..
  8. ATF2 in melanoma development and progression
    ZE apos EV A RONAI; Fiscal Year: 2012
    ..Our proposed studies will extend the use of relevant mouse melanoma models to assess ATF2 role in melanoma development and to identify and characterize the mechanisms underlying ATF2 role in the development of this tumor type. ..
  9. SIGNALING PATHWAYS FOR UV-INDUCED MELANOGENIC RESPONSE
    Zalfa Abdel-Malek; Fiscal Year: 2012
    ..The incidence of melanoma in the U.S. and Eastern countries continues to rise with no effective treatment for advanced disease;hence the relevance of this project for public health. ..
  10. A new approach to identify rare genetic variants influencing melanoma risk
    Fabienne Lesueur; Fiscal Year: 2013
    ....
  11. Response to Burn Injury: Role of the Melanocortin System in Wound Repair
    NICOLE SIMONE GIBRAN; Fiscal Year: 2013
    ..We will also determine the effect of loss of function and gain of function for the melanocortin 1 receptor on fibroblast responses including proliferation, migration, differentiation, and protein synthesis. ..
  12. A MODEL FOR GENETIC SUSCEPTIBILITY: MELANOMA
    Marianne Berwick; Fiscal Year: 2003
    ..It has substantial potential for application to other areas of cancer susceptibility. ..
  13. Hensin Tsao; Fiscal Year: 2016
    ....
  14. Targeted Polymer Micelles for Treatment of Metastatic Melanoma
    Kevin N Sill; Fiscal Year: 2013
    ..Completion of these aims will provide essential preclinical data for the further advancement of a taxane loaded, MC1R targeted micelle formulation into IND-enabling Phase 2 studies. ..
  15. Molecular signatures of melanoma histology and progression: A Population Based A
    Abrar A Qureshi; Fiscal Year: 2013
    ..Evaluate genome-wide (6,000 genes) association with BRAF/NRAS/MC1R status and melanoma recurrence and mortality due to melanoma ..
  16. Lei Wang; Fiscal Year: 2016
    ..In this proposal, I also elucidate the molecular mechanism by which T[unreadable]4 is therapeutically effective. This research will provide the essential pre-clinical data for translation to a phase 1 clinical trial. ..
  17. Melanocyte-Keratinocyte Cross-Talk In Relation To Barrier Function
    Peter M Elias; Fiscal Year: 2013
    ..Conversely, they should pinpoint epidermal-derived signals that regulate the development of interfollicular pigmentation in response to exogenous stress. ..
  18. Molecular control of melanocortin receptor signaling
    Glenn L Millhauser; Fiscal Year: 2013
    ..Analogous strategies will be used with members of the 2-defensin family to advance the understanding of the defensin fold and to produce useful protein for pharmacological and structural studies. ..
  19. Elizabeth C Engle; Fiscal Year: 2015
    ..During the previous grant cycle, we identified the CFEOM3 gene to be TUBB3, which encodes the neuron-specific [unreadable]-tubulin isotype III, and defined this as a fourth ..
  20. Longitudinal Population-Based Study of Vulvodynia
    Barbara D Reed; Fiscal Year: 2012
    ....
  21. The effect of pathological mutations in beta-III tubulin on microtubules and axon
    ADRIANNE LYNN KOLPAK; Fiscal Year: 2012
    ..In one of these disorders, congenital fibrosis of the extraocular muscles type 3 (CFEOM3), patients exhibit ocular motility defects due to failed cranial nerve innervation of the extraocular muscles...
  22. Fifth International Melanocortin Meeting
    ROGER CONE; Fiscal Year: 2002
    ..To facilitate the gathering of a large international audience, funds are specifically requested to cover travel expenses for 17 speakers. ..
  23. Role of Thymosin Beta-4 during Cardiac Development and Myocardial Cell Survival
    Ildiko Bock Marquette; Fiscal Year: 2009
    ....
  24. Richard P Phipps; Fiscal Year: 2016
    ..We will assess an anti-inflammatory melanocortin derivative with therapeutic potential for vulvodynia and investigate the underlying molecular mechanism(s). ..
  25. Dental Anxiety, Pain & Melanocortin-1 Receptor Mutations
    Edwin Liem; Fiscal Year: 2005
    ....
  26. Discovery of Alpha-MSH Analogs for Skin Cancer Prevention
    Zalfa Abdel Malek; Fiscal Year: 2009
    ..abstract_text> ..
  27. Sex-Related Genetic Influences on Pain and Analgesia
    Roger Fillingim; Fiscal Year: 2009
    ....
  28. Neurosteroid Modulation of Extrasynaptic GABAA Receptors
    EYDITH JANICE COMENENCIA ORTIZ; Fiscal Year: 2012
    ..The studies in this application will provide insight into neurosteroid-mediated alterations in neuronal excitability an might contribute to the development of novel treatments for postpartum depression, epilepsy and anxiety disorders. ..
  29. Molecular Epidemiology of Melanoma
    Peter Kanetsky; Fiscal Year: 2006
    ..Analyses will be undertaken to evaluate the role of candidate genotypes and other risk factors in melanoma etiology, including genotype by environment interactions. ..
  30. The role of signal transduction cascades in mediating papillomavirus infection.
    CYNTHIA YVONNE ABBAN; Fiscal Year: 2012
    ..To approach this study, I plan to use re-expressed Wild-Type (WT) beta 4 keratinocytes and beta 4 null keratinocytes to determine if the virus receptor interaction in aim 1 is needed for ..
  31. Variants in CHRNA5/CHRNA3/CHRNB4 and nicotine dependence
    Xiangning Chen; Fiscal Year: 2010
    ..large scale genetic studies have found that several variants in the nicotinic receptor alpha 5, alpha 3 and beta 4 genes are significantly associated with heavy smoking and nicotine dependence, including one functional ..
  32. Na Channel beta4 as a Gene Therapy Target for Epilepsy
    Edward Perez-Reyes; Fiscal Year: 2013
    ..The overall goal is to develop a delivery system for the shRNA that can be used in the clinic and to test its efficacy in animal models of TLE. ..
  33. Mouse model of vestibulodynia using recurrent vulvovaginal Candidiasis
    MELISSA ANNE FARMER; Fiscal Year: 2010
    ..g., topical capsaicin) and to stimulate the development of new pharmacological interventions. ..
  34. Integrin Beta 4 in Vascular Inflammatory Responses
    Jeffrey R Jacobson; Fiscal Year: 2013
    ..Accordingly, we now hypothesize that integrin [unreadable]4 mediates EC inflammatory responses in ALI and may serve as a highly novel therapeutic target in this setting. ..
  35. STEVEN SANSOM; Fiscal Year: 2015
    ..Such understanding may help prevent the large number of deaths occurring each year from treating heart failure subjects with aldosterone receptor blockers that lead to hyperkalemia-induced ventricular arrhythmias. ..
  36. REGULATION OF PROLYL HYDROXYLASE
    Richard Berg; Fiscal Year: 1992
    ....
  37. PROGRAM PROJECT GRANT
    Jouni Uitto; Fiscal Year: 2006
    ..abstract_text> ..
  38. Development and Applications of Novel SERT PET Ligands
    Mark Goodman; Fiscal Year: 2006
    ..Once SERT binding is determined in depressed patients, we will be able to assess the relationship of SERT binding and treatment response to SSRIs. ..
  39. Development and Applications of Novel SERT PET Ligands
    Mark Goodman; Fiscal Year: 2004
    ..Once SERT binding is determined in depressed patients, we will be able to assess the relationship of SERT binding and treatment response to SSRIs. ..
  40. SPECT IMAGING IN PARKINSONIAN MODEL
    John Seibyl; Fiscal Year: 2000
    ..This study will serve as a useful paradigm for evaluating other methods for restoring brain dopamine systems if and when they become available. ..
  41. LAMININ PEPTIDES/RECEPTORS IN METASTATIC CELL FUNCTION
    LEO FURCHT; Fiscal Year: 1999
    ..We will use peptides from #1 above, free, coupled to various carriers, or "constrained" peptides we designed that may have greater effects and perhaps have greater half lives in vivo. ..
  42. GALACTOSYLTRANSFERASES--STRUCTURE AND REGULATION
    Keith Brew; Fiscal Year: 2003
    ..The activity and structure will be investigated using a recombinant form of this protein. ..
  43. CHRONIC NICOTINE-INFUSION INDUCED MEMORY IMPROVEMENT
    Edward Levin; Fiscal Year: 2000
    ..These studies will further our understanding of the neural systems underlying cognitive function and dysfunction. This will be of critical importance for the development of nicotinic-based therapeutics for cognitive dysfunction. ..
  44. RUTHENIUM-97 DIAGNOSTIC RADIOPHARMACEUTICALS
    Carol Meyer; Fiscal Year: 1980
    ....
  45. CELL ADHESION IN TISSUE MORPHOGENESIS
    William Carter; Fiscal Year: 2001
    ..these results will define the molecular mechanism through which cell adhesion regulates gene expression and wound repair in epithelium. ..
  46. MELANOMA T CELL DEFINED ANTIGEN IDENTIFICATION
    KEVIN HOGAN; Fiscal Year: 2005
    ....
  47. ENDOCRINE CONTROL OF TESTIS FUNCTION
    STEVEN MONFORT; Fiscal Year: 1992
    ....
  48. NICOTINE ADDICTION IN MICE LACKING THE NEURONAL NACHR
    MARINA PICCIOTTO; Fiscal Year: 2004
    ..also attempt to compensate for deficits in animals lacking the Beta 2 subunit of the nAChR by overexpressing the Beta 4 subunit in the brains of these mice, allowing a molecular dissection of the roles of the different subunits of the ..
  49. INTERFERON-ALPHA/BETA IN RESPIRATORY VIRUS PATHOGENESIS
    Joan Durbin; Fiscal Year: 2004
    ..3) Alteration of RSV pathology by priming in the presence of IFN- alpha/beta. 4) Development of a vaccine strategy promoting strong induction of IFN- alpha/beta. ..
  50. Gene-environment Cancer Risks in Melanoma
    Melissa Gonzales; Fiscal Year: 2009
    ..abstract_text> ..
  51. NICOTINIC CHOLINERGIC SYSTEMS IN MUTANT MICE
    JOHN DANI; Fiscal Year: 2003
    ..The Mouse Core, headed by Dr. Beaudet, has already produced null mice lacking alpha3, alpha5, alpha7, beta3, or beta 4, and a mouse expressing in alpha7 L247T mutation that diminishes desensitization...
  52. RADIATION SIGNALING THROUGH THE ALPHA6 BETA 4 INTEGRIN
    Anne Cress; Fiscal Year: 2005
    ....
  53. Thymosin beta 4 and Autoimmune Ocular Surface Disease
    Gabriel Sosne; Fiscal Year: 2004
    ..Thymosin beta 4 (Tb4) promotes corneal wound healing and reduces inflammation in mice after chemical injury to the eye...
  54. Thymosin beta 4 and Corneal Wound Healing
    Gabriel Sosne; Fiscal Year: 2005
    ..abstract_text> ..
  55. 19th International Pigment Cell Conference - 2005
    Zalfa Abdel Malek; Fiscal Year: 2005
    ..abstract_text> ..
  56. Human Melanocortin-4 Receptor Polymorphisms
    Carrie Haskell Luevano; Fiscal Year: 2007
    ..Understanding obesity related mechanisms may ultimately result in therapeutic agents to prevent or treat the diseases associated with over eating. ..
  57. STRUCTURAL DETERMINANTS OF NEUROENDOCRINE RECEPTORS
    Carrie Haskell Luevano; Fiscal Year: 2008
    ..abstract_text> ..
  58. MELANOMA AND ALLELIC VARIATION IN THE MCIR GENE
    Peter Kanetsky; Fiscal Year: 2005
    ..Result from this project may provide valuable insight into the genetic predisposition to melanoma seen in some families, and may lead to more efficient mechanisms of primary prevention and clinical follow-up within these families. ..
  59. REGULATION OF ENERGY BALANCE BY MELANOCORTIN ANTAGONISTS
    Gregory Barsh; Fiscal Year: 2003
    ..abstract_text> ..
  60. Genetics of Dark Skin in Mice
    Gregory Barsh; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  61. Attractin and Mahoganoid in Spongy Neurodegeneration
    Gregory Barsh; Fiscal Year: 2007
    ..Investigating the biochemical, cellular, and genetic relationships between Atrn, Mahoganoid, and PrP is likely to provide general insight into the pathogenesis of spongy degeneration. [unreadable] [unreadable]..
  62. Peptide Hormone Structure Function
    Victor J Hruby; Fiscal Year: 2010
    ....