Gene Symbol: TTLL12
Description: tubulin tyrosine ligase like 12
Alias: dJ526I14.2, tubulin--tyrosine ligase-like protein 12, tubulin tyrosine ligase-like family, member 12
Wasylyk C, Zambrano A, Zhao C, Brants J, Abecassis J, Schalken J, et al
. Tubulin tyrosine ligase like 12 links to prostate cancer through tubulin posttranslational modification and chromosome ploidy. Int J Cancer. 2010;127:2542-53 pubmed publisher
..This study focused on 1 identified gene, TTLL12, which was predicted to modify tubulins, an established target for tumor therapy...
Janke C, Rogowski K, Wloga D, Regnard C, Kajava A, Strub J, et al
. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Science. 2005;308:1758-62 pubmed
..In the model protist Tetrahymena thermophila, two conserved types of polyglutamylases were characterized that differ in substrate preference and subcellular localization. ..
Brants J, Semenchenko K, Wasylyk C, Robert A, Carles A, Zambrano A, et al
. Tubulin tyrosine ligase like 12, a TTLL family member with SET- and TTL-like domains and roles in histone and tubulin modifications and mitosis. PLoS ONE. 2012;7:e51258 pubmed publisher
..These results suggest that hTTLL12 has non-catalytic functions related to tubulin and histone modification, which could be linked to its effects on mitosis and chromosome number stability. ..
Kuhnisch J, Thiering E, Heitmüller D, Tiesler C, Grallert H, Heinrich Weltzien R, et al
. Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH). Clin Oral Investig. 2014;18:677-82 pubmed publisher
Wen R, Xiao Y, Zhang Y, Yang M, Lin Y, Tang J. Identification of a novel transcript isoform of the TTLL12 gene in human cancers. Oncol Rep. 2016;36:3172-3180 pubmed publisher
Tubulin tyrosine ligase like 12 (TTLL12), a member of the tubulin tyrosine ligase (TTLL) family, has not been completely characterized to date...
Ju L, Zhu Y, Lei P, Yan D, Zhu K, Wang X, et al
. TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS. J Immunol. 2017;198:1274-1284 pubmed publisher
..methylation in the antiviral signaling pathway, we screened all the SET domain-containing proteins and identified TTLL12 as a negative regulator of RIG-I signaling...