Gene Symbol: TTC1
Description: tetratricopeptide repeat domain 1
Alias: TPR1, tetratricopeptide repeat protein 1, TPR repeat protein 1
Species: human
Products:     TTC1

Top Publications

  1. Marty C, Browning D, Ye R. Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras. Mol Cell Biol. 2003;23:3847-58 pubmed
    ..Using Saccharomyces cerevisiae two-hybrid screening, we identified tetratricopeptide repeat 1 (TPR1), a 292-amino-acid protein with three TPR motifs, as a Galpha16-binding protein...
  2. Niu D, Lin X, Kong X, Qu G, Cai B, Lee J, et al. SIZ1-Mediated SUMOylation of TPR1 Suppresses Plant Immunity in Arabidopsis. Mol Plant. 2019;12:215-228 pubmed publisher
    ..Overexpression of TOPLESS-RELATED 1 (TPR1), a SUPPRESSOR OF npr1-1, CONSTITUTIVE 1 (SNC1)-interacting protein, results in autoimmunity that reduces plant ..
  3. Cai Q, Liang C, Wang S, Hou Y, Gao L, Liu L, et al. The disease resistance protein SNC1 represses the biogenesis of microRNAs and phased siRNAs. Nat Commun. 2018;9:5080 pubmed publisher
    ..SNC1 represses the transcription of miRNA and phasiRNA loci, probably through the transcriptional corepressor TPR1. Intriguingly, nuclear SNC1 reduces the accumulation of phasiRNAs from three source R genes and concomitantly, the ..
  4. Cockburn J, Hesketh S, Mulhair P, Thomsen M, O Connell M, Way M. Insights into Kinesin-1 Activation from the Crystal Structure of KLC2 Bound to JIP3. Structure. 2018;26:1486-1498.e6 pubmed publisher
    ..with biophysical and molecular evolutionary analyses, reveals a kinesin-1 cargo binding site, located on KLC TPR1, which is conserved in homologs from sponges to humans...
  5. Cheng X, Zhang S, Tao W, Zhang X, Liu J, Sun J, et al. INDETERMINATE SPIKELET1 Recruits Histone Deacetylase and a Transcriptional Repression Complex to Regulate Rice Salt Tolerance. Plant Physiol. 2018;178:824-837 pubmed publisher
    ..Our findings illustrate an epigenetic mechanism by which IDS1 modulates salt stress signaling as well as salt tolerance in rice. ..
  6. Xu F, Kapos P, Cheng Y, Li M, Zhang Y, Li X. NLR-associating transcription factor bHLH84 and its paralogs function redundantly in plant immunity. PLoS Pathog. 2014;10:e1004312 pubmed publisher
    ..Together with previous finding that SNC1 associates with repressor TPR1 to repress negative regulators, we hypothesize that nuclear NLR proteins may interact with both transcriptional ..
  7. Chang Y, Chang C, Huang H, Lin C, Yeh K, Chang J. Detection of Molecular Alterations in Taiwanese Patients with Medullary Thyroid Cancer Using Whole-Exome Sequencing. Endocr Pathol. 2018;29:324-331 pubmed publisher
    ..We detected new somatic mutations in the BICD2, DLG1, FSD2, IL17RD, KLHL25, PAPPA2, PRDM2, PSEN1, SCRN1, and TTC1 genes...
  8. Röhl A, Wengler D, Madl T, Lagleder S, Tippel F, Herrmann M, et al. Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules. Nat Commun. 2015;6:6655 pubmed publisher
    ..The protein exhibits one binding site for Hsp90 (TPR2A) and two binding sites for Hsp70 (TPR1 and TPR2B). How these sites are used remained enigmatic...
  9. Takayanagi H, Yuzawa S, Sumimoto H. Structural basis for the recognition of the scaffold protein Frmpd4/Preso1 by the TPR domain of the adaptor protein LGN. Acta Crystallogr F Struct Biol Commun. 2015;71:175-83 pubmed publisher
    ..of the LGN-Frmpd1, LGN-mInsc and LGN-NuMA complexes reveals that these partner proteins interact with LGN TPR1-6 via a common core binding region with consensus sequence (E/Q)XEX4-5(E/D/Q)X1-2(K/R)X0-1(V/I)...

More Information


  1. Feghoul L, Mercier Delarue S, Salmona M, Ntsiba N, Dalle J, Baruchel A, et al. Genetic diversity of the human adenovirus species C DNA polymerase. Antiviral Res. 2018;156:1-9 pubmed publisher
    ..Mutations in the exonuclease domain accounted for 27.8%. The binding domains for the terminal protein (TPR), TPR1 and TPR2, presented a limited number of mutations, which were nonetheless frequently observed (62.5% and 58...
  2. Batista F, Seraphim T, Santos C, Gonzaga M, Barbosa L, Ramos C, et al. Low sequence identity but high structural and functional conservation: The case of Hsp70/Hsp90 organizing protein (Hop/Sti1) of Leishmania braziliensis. Arch Biochem Biophys. 2016;600:12-22 pubmed publisher
    ..This multi-domain protein comprises three tetratricopeptides domains (TPR1, TPR2A and TPR2B) and two Asp/Pro-rich domains...
  3. Shi L, Zhang W, Zou F, Mei L, Wu G, Teng Y. KLHL21, a novel gene that contributes to the progression of hepatocellular carcinoma. BMC Cancer. 2016;16:815 pubmed
    ..Up-regulation of VPS45, WIPI1, TTC1, IGBP1 and KLHL21 genes and down-regulation of FCGRT gene were confirmed in clinical HCC samples...
  4. Tsai C, Chao A, Jung S, Lin C, Chao A, Wang T. Stress-induced phosphoprotein 1 acts as a scaffold protein for glycogen synthase kinase-3 beta-mediated phosphorylation of lysine-specific demethylase 1. Oncogenesis. 2018;7:31 pubmed publisher
    ..Here, we show that STIP1 acts as a scaffold promoting the interaction between LSD1 and GSK3β. Specifically, the TPR1 and TPR2B domains of STIP1 are capable of binding with the AOL domain of LSD1, whereas the TPR2A and TPR2B domains ..
  5. Thebault P, Chirgadze D, Dou Z, Blundell T, Elowe S, Bolanos Garcia V. Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint). Biochem J. 2012;448:321-8 pubmed publisher
    ..The results of the present study provide an important insight into the molecular details of the mitotic functions of Mps1 including features that dictate substrate selectivity and kinetochore docking. ..
  6. Kwan D, Yung L, Ye R, Wong Y. Activation of Ras-dependent signaling pathways by G(14) -coupled receptors requires the adaptor protein TPR1. J Cell Biochem. 2012;113:3486-97 pubmed publisher
    ..may possess the ability to activate Ras/ERK by interacting with the adaptor protein tetratricopeptide repeat 1 (TPR1). Within the G?(q) family, the highly promiscuous G?(14) can relay signals from numerous receptors...
  7. Liu A, Lo R, Guo E, Ho M, Ye R, Wong Y. G?16 interacts with tetratricopeptide repeat 1 (TPR1) through its ?3 region to activate Ras independently of phospholipase C? signaling. BMC Struct Biol. 2011;11:17 pubmed publisher
    ..Using G?16 as a model, we asked if its recently discovered adaptor protein tetratricopeptide repeat 1 (TPR1) binds to the same region as its canonical effector, phospholipase C? (PLC?)...
  8. Ligon L, Tokito M, Finklestein J, Grossman F, Holzbaur E. A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity. J Biol Chem. 2004;279:19201-8 pubmed
    ..There is also a vesicle population with both dynein and kinesin I bound that may be capable of bi-directional motility along cellular microtubules. ..
  9. Maciejewski A, Ostapchenko V, Beraldo F, Prado V, Prado M, Choy W. Domains of STIP1 responsible for regulating PrPC-dependent amyloid-? oligomer toxicity. Biochem J. 2016;473:2119-30 pubmed publisher
    ..In contrast, multiple binding sites on STIP1 (DP1, TPR1 and TPR2A) contribute to PrP binding...
  10. Oh W, Song J. Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation. Mol Cells. 2003;16:84-91 pubmed
    Hsp40 and TPR1 are chaperone adaptors that regulate Hsp70-dependent folding processes by interacting with the amino terminal and carboxy terminal domains of Hsp70, respectively...
  11. Mesbah Uddin M, Guldbrandtsen B, Iso Touru T, Vilkki J, de Koning D, Boichard D, et al. Genome-wide mapping of large deletions and their population-genetic properties in dairy cattle. DNA Res. 2017;: pubmed publisher
    ..We observed higher differentiation among breeds for deletions in some genic-regions, such as ABCA12, TTC1, VWA3B, TSHR, DST/BPAG1, and CD1D...
  12. Nguyen T, Chenon M, Vilela F, Velours C, Aumont Nicaise M, Andreani J, et al. Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain. PLoS ONE. 2017;12:e0186354 pubmed publisher
    ..analysis reveals that the N-terminal capping helix is always involved in crystal packing contacts, especially in a TPR1:TPR1' contact which highlights its propensity to be a protein-protein interaction site...
  13. Liu F, Wu S, Hu S, Hsiao C, Wang C. Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats. J Biol Chem. 1999;274:34425-32 pubmed
    ..Using deletion mutants of these proteins, we demonstrated either by two-hybrid or in vitro binding assays that the tetratricopeptide repeat domains in these proteins are necessary and sufficient for mediating the interaction with hsc70. ..
  14. Durech M, Trcka F, Man P, Blackburn E, Hernychova L, Dvořáková P, et al. Novel Entropically Driven Conformation-specific Interactions with Tomm34 Protein Modulate Hsp70 Protein Folding and ATPase Activities. Mol Cell Proteomics. 2016;15:1710-27 pubmed publisher
    ..Tomm34 binds Hsp70 in a complex process; anchorage of the Hsp70 C terminus by the TPR1 domain is accompanied by additional contacts formed exclusively in the ATP-bound state of Hsp70 resulting in a high ..
  15. Murthy A, Bernards A, Church D, Wasmuth J, Gusella J. Identification and characterization of two novel tetratricopeptide repeat-containing genes. DNA Cell Biol. 1996;15:727-35 pubmed
    ..The first, represented by cDNA tpr1, is located in chromosome 5q32-33.2. It is ubiquitously expressed as a 1...
  16. Zhao S, Sancar A. Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity. Photochem Photobiol. 1997;66:727-31 pubmed
    ..We found that the tetratricopeptide repeat protein 1, Tpr1, and the protein serine/threonine phosphatase 5 (PP5) that contains the TPR motif specifically ..
  17. Liou S, Wang C. Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions. Arch Biochem Biophys. 2005;435:253-63 pubmed
    ..Moreover, in the presence of SGT, the degradation of the transporter in reticulocyte lysates is inhibited. Taking together, SGT can be separated into three structural units with distinct functions. ..
  18. Tartas A, Zarkadas C, Palaiomylitou M, Gounalaki N, Tzamarias D, Vlassi M. Ssn6-Tup1 global transcriptional co-repressor: Role of the N-terminal glutamine-rich region of Ssn6. PLoS ONE. 2017;12:e0186363 pubmed publisher
    ..that the N-terminal domain of Ssn6 comprising TPRs 1 to 3 is necessary and sufficient for this interaction and that TPR1 plays critical role...
  19. Maciejewski A, Prado V, Prado M, Choy W. Molecular basis for the interaction between stress-inducible phosphoprotein 1 (STIP1) and S100A1. Biochem J. 2017;474:1853-1866 pubmed publisher
    ..Isothermal titration calorimetry revealed that individual STIP1 TPR domains, TPR1, TPR2A and TPR2B, bind a single S100A1 dimer with significantly different affinities and that the TPR2B domain ..
  20. Goulas T, Garcia Ferrer I, Hutcherson J, Potempa B, Potempa J, Scott D, et al. Structure of RagB, a major immunodominant outer-membrane surface receptor antigen of Porphyromonas gingivalis. Mol Oral Microbiol. 2016;31:472-485 pubmed publisher
    ..It consists of four tetratrico peptide repeats (TPR1-4), each arranged as two helices connected by a linker, plus two extra downstream capping helices...