Gene Symbol: TSPYL
Description: TSPY like 1
Alias: TSPYL, testis-specific Y-encoded-like protein 1, TSPY-like protein 1
Species: human
Products:     TSPYL

Top Publications

  1. Puffenberger E, Hu Lince D, Parod J, Craig D, Dobrin S, Conway A, et al. Mapping of sudden infant death with dysgenesis of the testes syndrome (SIDDT) by a SNP genome scan and identification of TSPYL loss of function. Proc Natl Acad Sci U S A. 2004;101:11689-94 pubmed
    ..1-q22.31. This interval contained 27 genes, including two testis-specific Y-like genes (TSPYL and TSPYL4) of unknown function...
  2. Bansal S, Gupta N, Sankhwar S, Rajender S. Differential Genes Expression between Fertile and Infertile Spermatozoa Revealed by Transcriptome Analysis. PLoS ONE. 2015;10:e0127007 pubmed publisher
    ..Differences between comparison groups suggest that sperm RNA has strong potential of acting as markers for fertility evaluation. ..
  3. Na H, Yeum C, Kim H, Lee J, Kim J, Cho Y. TSPYL5-mediated inhibition of p53 promotes human endothelial cell function. Angiogenesis. 2019;22:281-293 pubmed publisher
    Testis-specific protein, Y-encoded like (TSPYL) family proteins (TSPYL1-6), which are members of the nucleosome assembly protein superfamily, have been determined to be involved in the regulation of various cellular functions...
  4. Hering R, Frade Martinez R, Bajanowski T, Poets C, Tschentscher F, Riess O. Genetic investigation of the TSPYL1 gene in sudden infant death syndrome. Genet Med. 2006;8:55-8 pubmed
    ..No association of sequence variations in the TSPYL1 gene and SIDS has been found in a German cohort. Genetic analysis of TSPYL1 seems to be of limited significance in the differential diagnosis of SIDS without dysgenesis of the testes. ..
  5. De Andrade T, Peterson K, Cunha A, Moreira L, Fattori A, Saad S, et al. Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster. Blood Cells Mol Dis. 2006;37:82-90 pubmed
    ..Interestingly, alpha-globin mRNA levels were decreased, similar to beta-globin in all reticulocyte samples analyzed. ..
  6. Vinci G, Brauner R, Tar A, Rouba H, Sheth J, Sheth F, et al. Mutations in the TSPYL1 gene associated with 46,XY disorder of sex development and male infertility. Fertil Steril. 2009;92:1347-50 pubmed publisher
    ..R89H mutation, and this data supports the hypothesis that mutations in TSPYL1 may contribute to anomalies of testicular development/function...
  7. Laguette N, Brégnard C, Hue P, Basbous J, Yatim A, Larroque M, et al. Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing. Cell. 2014;156:134-45 pubmed publisher
    ..Thus, our work not only reveals the identity of the cellular factors required for Vpr-mediated G2/M arrest but also identifies the SLX4com as a regulator of innate immunity. ..
  8. Schubert S, Haas C, Bartsch C, Mirshekarnejad M, Kohrs S, Roettinger I, et al. Variants in TSPYL1 are not associated with sudden infant death syndrome in a cohort of deceased infants from Switzerland. Mol Cell Probes. 2015;29:31-4 pubmed publisher
    ..The Amish founder mutation was not detected in the analyzed SIDS cases and controls. Mutations and polymorphisms in the TSPYL1 gene were not associated with SIDS in a cohort of 165 deceased Swiss infants. ..
  9. Qin S, Liu D, Kohli M, Wang L, VEDELL P, Hillman D, et al. TSPYL Family Regulates CYP17A1 and CYP3A4 Expression: Potential Mechanism Contributing to Abiraterone Response in Metastatic Castration-Resistant Prostate Cancer. Clin Pharmacol Ther. 2017;: pubmed publisher
    The testis-specific Y-encoded-like protein (TSPYL) gene family includes TSPYL1 to TSPYL6. We previously reported that TSPYL5 regulates cytochrome P450 (CYP) 19A1 expression...

More Information


  1. Vogel T, Dittrich O, Mehraein Y, Dechend F, Schnieders F, Schmidtke J. Murine and human TSPYL genes: novel members of the TSPY-SET-NAP1L1 family. Cytogenet Cell Genet. 1998;81:265-70 pubmed
    ..Because of a significant homology to TSPY, the novel genes were designated TSPY-Like (TSPYL) and were assigned as new members of the TSPY-SET-NAP1L1 family...
  2. Javaher P, Stuhrmann M, Wilke C, Frenzel E, Manukjan G, Grosshenig A, et al. Should TSPYL1 mutation screening be included in routine diagnostics of male idiopathic infertility?. Fertil Steril. 2012;97:402-6 pubmed publisher