TSPO

Summary

Gene Symbol: TSPO
Description: translocator protein
Alias: BPBS, BZRP, DBI, IBP, MBR, PBR, PBS, PKBS, PTBR, mDRC, pk18, translocator protein, benzodiazepine peripheral binding site, mitochondrial benzodiazepine receptor, peripheral-type benzodiazepine receptor
Species: human
Products:     TSPO

Top Publications

  1. Costa B, Pini S, Gabelloni P, Da Pozzo E, Abelli M, Lari L, et al. The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals. Endocrinology. 2009;150:5438-45 pubmed publisher
    ..The C-terminal amino acid domain of the translocator protein (TSPO) has been demonstrated to bind cholesterol, thereby determining its mitochondrial translocation...
  2. Owen D, Yeo A, Gunn R, Song K, Wadsworth G, Lewis A, et al. An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28. J Cereb Blood Flow Metab. 2012;32:1-5 pubmed publisher
    11)C]PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron emission tomography (PET) to detect microglial activation...
  3. Owen D, Howell O, Tang S, Wells L, Bennacef I, Bergstrom M, et al. Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation. J Cereb Blood Flow Metab. 2010;30:1608-18 pubmed publisher
    11)C]PBR28, a radioligand targeting the translocator protein (TSPO), does not produce a specific binding signal in approximately 14% of healthy volunteers...
  4. Batarseh A, Papadopoulos V. Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. Mol Cell Endocrinol. 2010;327:1-12 pubmed publisher
    b>Translocator protein (TSPO) is an 18 kDa high affinity cholesterol- and drug-binding protein found primarily in the outer mitochondrial membrane...
  5. Veenman L, Shandalov Y, Gavish M. VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis. J Bioenerg Biomembr. 2008;40:199-205 pubmed publisher
    ..Other proteins also appear to be associated with the MPTP, for example, the 18 kDa mitochondrial Translocator Protein (TSPO), Bcl-2, hexokinase, cyclophylin D, and others...
  6. Han Z, Slack R, Li W, Papadopoulos V. Expression of peripheral benzodiazepine receptor (PBR) in human tumors: relationship to breast, colorectal, and prostate tumor progression. J Recept Signal Transduct Res. 2003;23:225-38 pubmed
    High levels of peripheral-type benzodiazepine receptor (PBR), the alternative-binding site for diazepam, are part of the aggressive human breast cancer cell phenotype in vitro...
  7. Kurumaji A, Nomoto H, Yamada K, Yoshikawa T, Toru M. No association of two missense variations of the benzodiazepine receptor (peripheral) gene and mood disorders in a Japanese sample. Am J Med Genet. 2001;105:172-5 pubmed
    The benzodiazepine receptor (peripheral) (BZRP) plays an important role in the steroid syntheses of the adrenal glands and brain, which is possibly involved in the pathophysiology of mood disorders...
  8. Galiegue S, Casellas P, Kramar A, Tinel N, Simony Lafontaine J. Immunohistochemical assessment of the peripheral benzodiazepine receptor in breast cancer and its relationship with survival. Clin Cancer Res. 2004;10:2058-64 pubmed
    The peripheral benzodiazepine receptor (PBR) expression has been shown dramatically increased in neoplastic tissues and tumor cell lines originated from ovary, liver, colon, breast, or brain relative to untransformed tissues...
  9. Papadopoulos V, Baraldi M, Guilarte T, Knudsen T, Lacapere J, Lindemann P, et al. Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci. 2006;27:402-9 pubmed
    ..b>Translocator protein (18kDa) is proposed as a new name, regardless of the subcellular localization of the protein.

More Information

Publications142 found, 100 shown here

  1. Chen M, Li T, Zhang R, Li L, Lu J, Bao Y, et al. [Clinical features of non-alcoholic fatty liver disease and its relationship with serum C-peptide levels in patients with latent autoimmune diabetes in adults]. Zhonghua Yi Xue Za Zhi. 2015;95:3575-8 pubmed
    ..01), but the serum total bilirubin (TBI) and direct bilirubin (DBI) level had no significant inter-group difference (P>0.05)...
  2. Pawlicki P, Milon A, Zarzycka M, Galas J, Tworzydlo W, Kaminska A, et al. Does signaling of estrogen-related receptors affect structure and function of bank vole Leydig cells?. J Physiol Pharmacol. 2017;68:459-476 pubmed
    ..05; P < 0.01 and P < 0.001) of steroidogenic (lutropin receptor (LHR), translocator protein (TSPO), steroidogenic acute regulatory protein (StAR)) and secretory (insulin-like protein 3 (INSL3) and ..
  3. Alves M, Boia R, Campos E, Martins J, Nunes S, Madeira M, et al. Subtle thinning of retinal layers without overt vascular and inflammatory alterations in a rat model of prediabetes. Mol Vis. 2018;24:353-366 pubmed
    ..Iba1 and MHC-II immunoreactivity and translocator protein (TSPO) mRNA levels were assessed to study the microglial number and activation state...
  4. Lassance L, Haghiac M, Minium J, Catalano P, Hauguel De Mouzon S. Obesity-induced down-regulation of the mitochondrial translocator protein (TSPO) impairs placental steroid production. J Clin Endocrinol Metab. 2015;100:E11-8 pubmed publisher
    ..Cholesterol trafficking is the limiting step in sex steroid biosynthesis and is mainly mediated by the translocator protein (TSPO), present in the mitochondrial outer membrane...
  5. Vasiliadou I, Sánchez Vázquez R, Molina R, Martinez F, Melero J, Bautista L, et al. Biological removal of pharmaceutical compounds using white-rot fungi with concomitant FAME production of the residual biomass. J Environ Manage. 2016;180:228-37 pubmed publisher
    ..of individual and combined strains showed a total removal (100%) of diclofenac (DCF), gemfibrozil (GFZ), ibuprofen (IBP), progesterone (PGT) and ranitidine (RNT)...
  6. Cole T, Coburn J, Dao K, Roqué P, Chang Y, Kalia V, et al. Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain. Toxicology. 2016;374:1-9 pubmed publisher
    ..as measured by increased Iba1 (ionized calcium-binding adapter molecule 1) expression, and of TSPO (translocator protein) binding...
  7. Scholz R, Sobotka M, Caramoy A, Stempfl T, Moehle C, Langmann T. Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration. J Neuroinflammation. 2015;12:209 pubmed publisher
    ..alerted microglia in the outer retina and down-regulated the expression of the microglial activation marker translocator protein (18 kDa) (TSPO), CD68, and activated microglia/macrophage whey acidic protein (AMWAP) already 1 day after ..
  8. Beattie M, Adekola L, Papadopoulos V, Chen H, Zirkin B. Leydig cell aging and hypogonadism. Exp Gerontol. 2015;68:87-91 pubmed publisher
    ..cAMP production, the cholesterol transport proteins steroidogenic acute regulatory (STAR) protein and translocator protein (TSPO), and downstream steroidogenic enzymes of the mitochondria and smooth endoplasmic reticulum...
  9. Ramirez K, Niraula A, Sheridan J. GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations. Brain Behav Immun. 2016;51:154-68 pubmed publisher
    ..the central benzodiazepine binding site (CBBS) in the central nervous system (CNS), lorazepam binds to the translocator protein (TSPO) with high affinity causing immunomodulation...
  10. Caridis A, Lightbody R, Tarlton J, Dolan S, Graham A. Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells. Biosci Rep. 2019;: pubmed publisher
    ..the roles of mitochondrial cholesterol trafficking (steroidogenic acute regulatory protein [StAR] and 18kDa translocator protein [TSPO]) and metabolizing proteins in insulin-secreting cells remain wholly uncharacterised...
  11. Namsi A, Nury T, Hamdouni H, Yammine A, Vejux A, Vervandier Fasseur D, et al. Induction of Neuronal Differentiation of Murine N2a Cells by Two Polyphenols Present in the Mediterranean Diet Mimicking Neurotrophins Activities: Resveratrol and Apigenin. Diseases. 2018;6: pubmed publisher
    ..Moreover, RSV and API do not stimulate the expression of the diazepam-binding inhibitor (DBI), the precursor of ODN...
  12. Kitazawa T, Kitazawa K. Prolonged bed rest impairs rapid CPI-17 phosphorylation and contraction in rat mesenteric resistance arteries to cause orthostatic hypotension. Pflugers Arch. 2017;469:1651-1662 pubmed publisher
    Prolonged bed rest (PBR) causes orthostatic hypotension (OH)...
  13. Hur J, Lee J. A new enterotoxigenic Escherichia coli vaccine candidate constructed using a Salmonella ghost delivery system: comparative evaluation with a commercial vaccine for neonatal piglet colibacillosis. Vet Immunol Immunopathol. 2015;164:101-9 pubmed publisher
    ..FasA, and F41 fimbrial proteins were individually cloned into an expression/ghost plasmid (pJHLP184) carrying the pBR origin, asd, the ompA signal sequence to direct antigens to the cell membrane, cI857/λPR promoter, araC ParaBAD, ..
  14. Vidanapathirana P, Hasan F, Mussio K, Pande A, Brands M, Siraj N, et al. Cationic ionic liquid surfactant-polyacrylamide gel electrophoresis for enhanced separation of acidic and basic proteins with single-step ribonuclease b glycoforms separation. J Chromatogr A. 2017;1515:245-251 pubmed publisher
    Cationic ionic liquids-based surfactants (ILS), such as 4-methyl pyridinium bromide (CnPBr, where n=4,6,8), were used in preparation of polyacrylamide gels, sample buffer, and running buffer for cationic ILS polyacrylamide gel ..
  15. Thomas M, Burk O, Klumpp B, Kandel B, Damm G, Weiss T, et al. Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα). Mol Pharmacol. 2013;83:709-18 pubmed publisher
    ..mobility shift and luciferase reporter-gene assays, we identified three functional PPARα-binding regions (PBR-I, -II, and -III) within ∼12 kb of the CYP3A4 upstream sequence...
  16. García García L, Shiha A, Fernández de la Rosa R, Delgado M, Silván Ã, Bascuñana P, et al. Metyrapone prevents brain damage induced by status epilepticus in the rat lithium-pilocarpine model. Neuropharmacology. 2017;123:261-273 pubmed publisher
    ..and, for a marker of activated microglia by in vitro autoradiography with the TSPO (18 kDa translocator protein) radioligand [18F]GE180...
  17. Graham A. Mitochondrial regulation of macrophage cholesterol homeostasis. Free Radic Biol Med. 2015;89:982-92 pubmed publisher
    ..even in steroidogenic tissues, but may include steroidogenic acute regulatory protein and the 18 kDa translocator protein, together with voltage-dependent anion channels, ATPase AAA domain containing protein 3A, and optic atrophy ..
  18. Schaller S, Paradis S, Ngoh G, Assaly R, Buisson B, Drouot C, et al. TRO40303, a new cardioprotective compound, inhibits mitochondrial permeability transition. J Pharmacol Exp Ther. 2010;333:696-706 pubmed publisher
    ..TRO40303 binds specifically to the mitochondrial translocator protein 18 kDa (TSPO) at the cholesterol site...
  19. Flannery B, Bruun D, Rowland D, Banks C, Austin A, Kukis D, et al. Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication. J Neuroinflammation. 2016;13:267 pubmed
    ..tomography (PET) imaging of [11C]-(R)-PK11195, a ligand for the 18-kDa mitochondrial membrane translocator protein (TSPO)...
  20. Shimizu S, Shimizu T, Tsounapi P, Higashi Y, Martin D, Nakamura K, et al. Effect of Silodosin, an Alpha1A-Adrenoceptor Antagonist, on Ventral Prostatic Hyperplasia in the Spontaneously Hypertensive Rat. PLoS ONE. 2015;10:e0133798 pubmed publisher
    ..There was a significant increase in blood pressure, prostate weight, prostate body weight ratio (PBR), tissue levels of MDA, IL-6, CXCL1/CINC1, TNF-α, TGF-β1, bFGF and α-SMA in the SHR compared to the WKY ..
  21. Berge R, Ramsvik M, Bohov P, Svardal A, Nordrehaug J, Rostrup E, et al. Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study. Lipids Health Dis. 2015;14:163 pubmed publisher
    ..Krill oil intake increased the antioxidant capacity, double bond index (DBI) and the fatty acid anti-inflammatory index...
  22. Wu Y, Kazumura K, Maruyama W, Osawa T, Naoi M. Rasagiline and selegiline suppress calcium efflux from mitochondria by PK11195-induced opening of mitochondrial permeability transition pore: a novel anti-apoptotic function for neuroprotection. J Neural Transm (Vienna). 2015;122:1399-407 pubmed publisher
    ..by rasagiline and selegiline was examined in apoptosis induced by PK11195, a ligand of the outer membrane translocator protein 18 kDa (TSPO) in SH-SY5Y cells...
  23. Maranho L, Baena Nogueras R, Lara Martín P, DelValls T, Martín Díaz M. Bioavailability, oxidative stress, neurotoxicity and genotoxicity of pharmaceuticals bound to marine sediments. The use of the polychaete Hediste diversicolor as bioindicator species. Environ Res. 2014;134:353-65 pubmed publisher
    ..some of the most representative pharmaceutical products found in the environment: carbamazepine (CBZ), ibuprofen (IBP), fluoxetine (FX), 17α-ethynylestradiol (EE2) and propranolol (PRO), including the environmental concentrations...
  24. Horiguchi Y, Ohta N, Yamamoto S, Koide M, Fujino Y. Midazolam suppresses the lipopolysaccharide-stimulated immune responses of human macrophages via translocator protein signaling. Int Immunopharmacol. 2019;66:373-382 pubmed publisher
    ..We analyzed the involvement of translocator protein (TSPO) in the immunomodulatory effects of midazolam using TSPO ligands...
  25. Bazylińska U, Saczko J. Nanoemulsion-templated polylelectrolyte multifunctional nanocapsules for DNA entrapment and bioimaging. Colloids Surf B Biointerfaces. 2016;137:191-202 pubmed publisher
    ..stabilized by gemini-type ammonium salts: N,N,N',N'-tetramethyl-N,N'-di(dodecyl)-ethylenediammonium bromide, d(DDA)PBr and N,N,N',N'-tetramethyl-N,N'-di(dodecyl)-butylenediammonium d(DDA)BBr...
  26. Bahdoudi S, Ghouili I, Hmiden M, Do Rego J, Lefranc B, Leprince J, et al. Neuroprotective effects of the gliopeptide ODN in an in vivo model of Parkinson's disease. Cell Mol Life Sci. 2018;75:2075-2091 pubmed publisher
    ..The octadecaneuropeptide (ODN) is a diazepam-binding inhibitor (DBI)-derived peptide, expressed by astrocytes, which protects neurons against oxidative cell damages and apoptosis in ..
  27. Bai M, Bornhop D. Recent advances in receptor-targeted fluorescent probes for in vivo cancer imaging. Curr Med Chem. 2012;19:4742-58 pubmed
    ..CCK(2)) receptor, gastrin-releasing peptide (GRP) receptor, endothelin A (ET(A)) receptor, translocator protein (TSPO) receptor, epidermal growth factor (EGF) receptor, human epidermal growth factor receptor 2 (HER2), ..
  28. Bredow M, Vanderbeld B, Walker V. Knockdown of Ice-Binding Proteins in Brachypodium distachyon Demonstrates Their Role in Freeze Protection. PLoS ONE. 2016;11:e0167941 pubmed publisher
    ..grass and model crop, Brachypodium distachyon, we characterized putative IBPs (BdIRIs) and generated the first 'IBP-knockdowns'...
  29. Li H, Li M, Shi E, Jin W, Wood K, Gonzales R, et al. A translocator protein 18 kDa agonist protects against cerebral ischemia/reperfusion injury. J Neuroinflammation. 2017;14:151 pubmed publisher
    ..b>Translocator protein 18 kDa (TSPO) mainly localized to the mitochondrial outer membrane is predominantly expressed in glia ..
  30. Collste K, Forsberg A, Varrone A, Amini N, Aeinehband S, Yakushev I, et al. Test-retest reproducibility of [(11)C]PBR28 binding to TSPO in healthy control subjects. Eur J Nucl Med Mol Imaging. 2016;43:173-183 pubmed publisher
    The PET radioligand [(11)C]PBR28 binds to the translocator protein (TSPO), a marker of brain immune activation...
  31. Di Bella G, Di Prima N, Di Trapani D, Freni G, Giustra M, Torregrossa M, et al. Performance of membrane bioreactor (MBR) systems for the treatment of shipboard slops: Assessment of hydrocarbon biodegradation and biomass activity under salinity variation. J Hazard Mater. 2015;300:765-778 pubmed publisher
    ..Nevertheless, a slight adaptation of the biomass to the new conditions was observed, with increasing removal efficiencies, despite the significant slops percentage. ..
  32. Ensano B, Borea L, Naddeo V, de Luna M, Belgiorno V. Control of emerging contaminants by the combination of electrochemical processes and membrane bioreactors. Environ Sci Pollut Res Int. 2019;26:1103-1112 pubmed publisher
    ..A conventional membrane bioreactor (MBR) was operated as a control test...
  33. Cheng B, Wang J, Liu W, Cui Z, Bi F, Jia H, et al. Membrane fouling reduction in a cost-effective integrated system of microbial fuel cell and membrane bioreactor. Water Sci Technol. 2017;76:653-661 pubmed publisher
    Microbial fuel cells (MFC) and membrane bioreactors (MBR) are promising technologies for wastewater treatment. However, both of them have some drawbacks and application limitations...
  34. Gyengesi E, Liang H, Millington C, Sonego S, Sirijovski D, Gunawardena D, et al. Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice. Pharm Res. 2018;35:22 pubmed publisher
    ..Total numbers of Iba-1+ microglia, TSPO+ cells were determined using an unbiased stereological method...
  35. Galiano F, Friha I, Deowan S, Hoinkis J, Xiaoyun Y, Johnson D, et al. Novel low-fouling membranes from lab to pilot application in textile wastewater treatment. J Colloid Interface Sci. 2018;515:208-220 pubmed publisher
    ..The PBM membranes were finally successfully scaled-up (total membrane area 0.33?m2) and applied in a pilot membrane bioreactor (MBR) unit for the treatment of real textile wastewater.
  36. Chaudhry R, Holloway R, Cath T, Nelson K. Impact of virus surface characteristics on removal mechanisms within membrane bioreactors. Water Res. 2015;84:144-52 pubmed publisher
    ..similar size and shape but with different external surface capsid proteins by a bench-scale membrane bioreactor (MBR)...
  37. Elkamhawy A, Viswanath A, Pae A, Kim H, Heo J, Park W, et al. Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM). Eur J Med Chem. 2015;103:210-22 pubmed publisher
    ..Compounds 11, 20, and 24 bound to the translocator protein 18 kDa (TSPO) in submicromolar range using [(3)H] PK-11195 binding affinity assay...
  38. Le Roy A, Wang K, Schaack B, Schuck P, Breyton C, Ebel C. AUC and Small-Angle Scattering for Membrane Proteins. Methods Enzymol. 2015;562:257-86 pubmed publisher
    ..nibib.nih.gov/software) and Gussi (http://biophysics.swmed.edu/MBR/software...
  39. Qi C, Wang J, Lin Y. New insight into influence of mechanical stirring on membrane fouling of membrane bioreactor: Mixed liquor properties and hydrodynamic conditions. Bioresour Technol. 2016;211:654-63 pubmed publisher
    ..of the gel layer increased significantly under low stirring rates, which indicated that the fouling rates of MBR in different stages were attributed to gel layer variation...
  40. Del Giudice P, Belardin L, Camargo M, Zylbersztejn D, Carvalho V, Cardozo K, et al. Determination of testicular function in adolescents with varicocoele - a proteomics approach. Andrology. 2016;4:447-55 pubmed publisher
    ..The suggested biomarkers are Cab45/SDF4 (Q9BRK5), protein lefty-1 (O75610), DNase I (P24855), PAP2-alpha (O14494), IBP-7 (Q16270), HDC (P01860), and CRISP-3 (P54108)...
  41. Niu Z, Zhang Z, Liu S, Miyoshi T, Matsuyama H, Ni J. Discrepant membrane fouling of partial nitrification and anammox membrane bioreactor operated at the same nitrogen loading rate. Bioresour Technol. 2016;214:729-736 pubmed publisher
    ..fouling was found in anammox membrane bioreactor, compared to partial nitrification membrane bioreactor (PN-MBR) operated at the same nitrogen loading rate...
  42. Zhang D, Eng C, Stuckey D, Zhou Y. Effects of ZnO nanoparticle exposure on wastewater treatment and soluble microbial products (SMPs) in an anoxic-aerobic membrane bioreactor. Chemosphere. 2017;171:446-459 pubmed publisher
    ..effect of zinc oxide nanoparticles (ZnO NPs) on the performance of an anoxic-aerobic submerged membrane bioreactor (MBR), and the characterization of the soluble microbial products (SMPs) produced in the presence of ZnO NPs was ..
  43. Odriozola J, Beltrán S, Dalmau M, Sancho L, Comas J, Rodriguez Roda I, et al. Model-based methodology for the design of optimal control strategies in MBR plants. Water Sci Technol. 2017;75:2546-2553 pubmed publisher
    ..The obtained optimal control strategies have shown a significant improvement in performance in comparison with fixed operation for the studied case, reducing the total nitrogen by 40%. ..
  44. Luo J, Lv P, Zhang J, Fane A, McDougald D, Rice S. Succession of biofilm communities responsible for biofouling of membrane bio-reactors (MBRs). PLoS ONE. 2017;12:e0179855 pubmed publisher
    ..This study investigated the composition and changes in the microbial communities fouling MBR membranes over time and correlated those changes with an increase in transmembrane pressure (TMP)...
  45. Jean Bart E, Moutet C, Dauphinot V, Krolak Salmon P, Mouchoux C. Exposure to anticholinergic and sedative medicines as indicators of high-risk prescriptions in the elderly. Int J Clin Pharm. 2017;39:1237-1247 pubmed publisher
    ..and sedation-related ADRs in an elderly hospitalized patient population using the Drug Burden Index (DBI), Anticholinergic Drug Scale (ADS), and Sedative Load Model (SLM)...
  46. Liu X, Liu H, Xu S, Tang Z, Xia W, Cheng Z, et al. Spinal translocator protein alleviates chronic neuropathic pain behavior and modulates spinal astrocyte-neuronal function in rats with L5 spinal nerve ligation model. Pain. 2016;157:103-16 pubmed publisher
    Recent studies reported the translocator protein (TSPO) to play critical roles in several kinds of neurological diseases including the inflammatory and neuropathic pain. However, the precise mechanism remains unclear...
  47. Yin Z, Tarabara V, Xagoraraki I. Effect of pressure relaxation and membrane backwash on adenovirus removal in a membrane bioreactor. Water Res. 2016;88:750-757 pubmed publisher
    ..permeate backwash are two commonly used physical methods for membrane fouling mitigation in membrane bioreactor (MBR) systems...
  48. Leyva Díaz J, Poyatos J. Start-up of membrane bioreactor and hybrid moving bed biofilm reactor-membrane bioreactor: kinetic study. Water Sci Technol. 2015;72:1948-53 pubmed publisher
    A hybrid moving bed biofilm reactor-membrane bioreactor (hybrid MBBR-MBR) system was studied as an alternative solution to conventional activated sludge processes and membrane bioreactors...
  49. Daugherty D, Chechneva O, Mayrhofer F, Deng W. The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis. Sci Rep. 2016;6:22556 pubmed publisher
    The mitochondrial translocator protein (TSPO) has been implicated in CNS diseases...
  50. Song C, Xia X, Hu Z, Liang Y, Wang J. Characteristics of Plasmonic Bragg Reflectors with Graphene-Based Silicon Grating. Nanoscale Res Lett. 2016;11:419 pubmed publisher
    We propose a plasmonic Bragg reflector (PBR) composed of a single-layer graphene-based silicon grating and numerically study its performance. An external voltage gating has been applied to graphene to tune its optical conductivity...
  51. Wu T, Englehardt J. Mineralizing urban net-zero water treatment: Field experience for energy-positive water management. Water Res. 2016;106:352-363 pubmed publisher
    ..The system comprised septic tank, denitrifying membrane bioreactor (MBR), iron-mediated aeration (IMA) reactor, vacuum ultrafilter, and peroxone or UV/H2O2 advanced ..
  52. Qian Q, Liang Y, Liang Y, Shao H, Zhang M, Xiao T, et al. Tunable Multiple-Step Plasmonic Bragg Reflectors with Graphene-Based Modulated Grating. Sensors (Basel). 2016;16: pubmed
    We propose a novel plasmonic Bragg reflector (PBR) based on graphene with multiple-step silicon structure...
  53. Yuan C, Hung C, Huang T. Application of RuO2/Ni foam electrodes for remediation of ibuprofen in soil matrix-the effect of electrokinetic parameters. Environ Sci Pollut Res Int. 2018;25:5181-5190 pubmed publisher
    ..Among the PPCPs, ibuprofen (IBP) is one of the most known non-steroidal anti-inflammatory drugs, which has been found at a high concentration in ..
  54. Duke Novakovski T, Ambros B, Feng C, Carr A. The effect of anesthetic drug choice on accuracy of high-definition oscillometry in laterally recumbent horses. Vet Anaesth Analg. 2017;44:589-593 pubmed publisher
    ..Invasive blood pressure (IBP), SAP, MAP, DAP and HR were recorded during HDO cycling...
  55. Wang Y, Lin H, Tong X, Hou Y, Chang Y, Zhang J. DNA demethylation activates genes in seed maternal integument development in rice (Oryza sativa L.). Plant Physiol Biochem. 2017;120:169-178 pubmed publisher
    ..genes revealed extensive occurrence of DNA hypomethylation triggered by double fertilization at IAP compared with IBP, suggesting that DNA demethylation might be a key mechanism to activate numerous maternal controlling genes...
  56. Kudryashov N, Kalinina T, Shimshirt A, Korolev A, Volkova A, Voronina T. Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice. Behav Pharmacol. 2017;: pubmed publisher
    ..The influence of the mitochondrial translocator protein (TSPO) activity on the antidepressant-like effect of fluoxetine (20?mg/kg i.p.) in the FST was also studied...
  57. Bloch Shilderman E, Rabinovitz I, Egoz I, Yacov G, Allon N, Nili U. Determining a threshold sub-acute dose leading to minimal physiological alterations following prolonged exposure to the nerve agent VX in rats. Arch Toxicol. 2018;92:873-892 pubmed publisher
    ..were neither accompanied by observable signs of intoxication nor by changes in motor function, circadian rhythm or TSPO level (a reliable marker of brain damage). Following exposure to lower doses of 2.25 and 0...
  58. Liu J, Zhang P, Li H, Tian Y, Wang S, Song Y, et al. Denitrification of landfill leachate under different hydraulic retention time in a two-stage anoxic/oxic combined membrane bioreactor process: Performances and bacterial community. Bioresour Technol. 2018;250:110-116 pubmed publisher
    Two-stage anoxic/oxic combined membrane bioreactor (A/O-A/O-MBR) process was used to treat leachate generated from Shenyang Laohuchong landfill, and the effect of hydraulic retention time (HRT) was studied...
  59. Levran O, Peles E, Randesi M, Correa Da Rosa J, Ott J, Rotrosen J, et al. Glutamatergic and GABAergic susceptibility loci for heroin and cocaine addiction in subjects of African and European ancestry. Prog Neuropsychopharmacol Biol Psychiatry. 2016;64:118-23 pubmed publisher
    ..In addition, SNPs GABRB3 rs7165224; DBI rs12613135; GAD1 SNPs rs2058725, rs1978340, rs2241164; and GRIN2A rs1650420 were previously reported in ..
  60. Harb M, Hong P. Molecular-based detection of potentially pathogenic bacteria in membrane bioreactor (MBR) systems treating municipal wastewater: a case study. Environ Sci Pollut Res Int. 2017;24:5370-5380 pubmed publisher
    Although membrane bioreactor (MBR) systems provide better removal of pathogens compared to conventional activated sludge processes, they do not achieve total log removal...
  61. Kalk N, Guo Q, Owen D, Cherian R, Erritzoe D, Gilmour A, et al. Decreased hippocampal translocator protein (18 kDa) expression in alcohol dependence: a [11C]PBR28 PET study. Transl Psychiatry. 2017;7:e996 pubmed publisher
    ..patients (ADP), using [11C]PBR28 positron emission tomography (PET), selective for the 18kDa translocator protein (TSPO) highly expressed in activated microglia and astrocytes...
  62. Hosoya T, Fukumoto D, Kakiuchi T, Nishiyama S, Yamamoto S, Ohba H, et al. In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study. J Neuroinflammation. 2017;14:69 pubmed publisher
    Upregulated levels of 18-kDa translocator proteins (TSPO) and type 2 endocannabinoid receptors (CB2) are considered to reflect different aspects of microglia-related neuroinflammatory responses in the brain...
  63. Tang J, Wang X, Hu Y, Ngo H, Li Y, Zhang Y. Applying fermentation liquid of food waste as carbon source to a pilot-scale anoxic/oxic-membrane bioreactor for enhancing nitrogen removal: Microbial communities and membrane fouling behaviour. Bioresour Technol. 2017;236:164-173 pubmed publisher
    ..of food waste (FLFW) was applied as an external carbon source in a pilot-scale anoxic/oxic-membrane bioreactor (A/O-MBR) system to enhance nitrogen removal for treating low COD/TN ratio domestic wastewater...
  64. Roukens R, Lauster F, Bara M, Eifert B, Willemsen D, Randall T, et al. [Costs associated with multiresistant bacteria in neurorehabilitation]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2017;60:1075-1082 pubmed publisher
    ..To analyze the added costs associated with the rehabilitation of patients with MBR, the DGNR Hygiene Commission identified criteria for a cost assessment...
  65. Fernández Hurst N, Zanetti S, Baez N, Bibolini M, Bouzat C, Roth G. Diazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis. J Neuroimmunol. 2017;313:145-151 pubmed publisher
    ..Also, we evaluated the expression of Translocator Protein (18kDa) (TSPO), which is a biomarker of neuroinflammatory diseases...
  66. Xi X, Tang M, Luo Z. Feature-Level Fusion of Surface Electromyography for Activity Monitoring. Sensors (Basel). 2018;18: pubmed publisher
    ..The Davies-Bouldin index (DBI) based on fuzzy c-means algorithms of the space obtained the lowest value compared with several fusion methods...
  67. Hosseinzadeh M, Bidhendi G, Torabian A, Mehrdadi N, Pourabdullah M. A new flat sheet membrane bioreactor hybrid system for advanced treatment of effluent, reverse osmosis pretreatment and fouling mitigation. Bioresour Technol. 2015;192:177-84 pubmed publisher
    ..treatment of effluent by simultaneously integrating electrical coagulation (EC) with a membrane bioreactor (MBR) and its performance was compared with conventional MBR...
  68. Jensen P, Feng L, Law I, Svarer C, Knudsen G, Mikkelsen J, et al. TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging. J Nucl Med. 2015;56:1386-90 pubmed publisher
    Here we compare translocator protein (TSPO) imaging using 6-chloro-2-(4'-(123)I-iodophenyl)-3-(N,N-diethyl)-imidazo[1,2-a]pyridine-3-acetamide SPECT ((123)I-CLINDE) and amino acid transport imaging using O-(2-(18)F-fluoroethyl)-l-tyrosine ..
  69. Himori N, Kunikata H, Shiga Y, Omodaka K, Maruyama K, Takahashi H, et al. The association between systemic oxidative stress and ocular blood flow in patients with normal-tension glaucoma. Graefes Arch Clin Exp Ophthalmol. 2016;254:333-41 pubmed publisher
    ..This study included 73 eyes of 73 patients with NTG. We assessed ocular blood flow by measuring mean blur rate (MBR) in the optic nerve head using laser speckle flowgraphy, both overall and separately in the vessel and tissue areas...
  70. Ravikumar B, Crawford D, Dellovade T, Savinainen A, Graham D, Liere P, et al. Differential efficacy of the TSPO ligands etifoxine and XBD-173 in two rodent models of Multiple Sclerosis. Neuropharmacology. 2016;108:229-37 pubmed publisher
    ..a rate-limiting step of cholesterol transport through the outer mitochondrial membrane via the transporter translocator protein (TSPO)...
  71. Matar G, Bagchi S, Zhang K, Oerther D, Saikaly P. Membrane biofilm communities in full-scale membrane bioreactors are not randomly assembled and consist of a core microbiome. Water Res. 2017;123:124-133 pubmed publisher
    ..due to the presence of large number of unique but rare operational taxonomic units (?13% of total reads in each MBR) in each sample...
  72. Thackeray J, Hupe H, Wang Y, Bankstahl J, Berding G, Ross T, et al. Myocardial Inflammation Predicts Remodeling and Neuroinflammation After Myocardial Infarction. J Am Coll Cardiol. 2018;71:263-275 pubmed publisher
    ..ligation or sham surgery, mice (n = 49) underwent serial whole-body PET imaging of the mitochondrial translocator protein (TSPO) as a marker of activated macrophages and microglia...
  73. Zhang Y, Xue J, Liu Y, Gamal El Din M. The role of ozone pretreatment on optimization of membrane bioreactor for treatment of oil sands process-affected water. J Hazard Mater. 2018;347:470-477 pubmed publisher
    Previously, anoxic-aerobic membrane bioreactor (MBR) coupled with mild ozonation pretreatment has been applied to remove toxic naphthenic acids (NAs) in oil sands process-affected water (OSPW)...
  74. Kurumaji A, Nomoto H, Yoshikawa T, Okubo Y, Toru M. An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample. J Neural Transm (Vienna). 2000;107:491-500 pubmed
    The benzodiazepine receptor (peripheral) (BZRP) mainly localized on glial cells plays a role in neurosteroid synthesis, and increases with glial proliferation...
  75. Zhang J. Mapping neuroinflammation in frontotemporal dementia with molecular PET imaging. J Neuroinflammation. 2015;12:108 pubmed publisher
    ..The first-generation translocator protein (TSPO) ligand ([(11)C]-PK11195) has been used to detect microglia activation in FTD, and the second-..
  76. Vaes R, Wouda R, Teijink J, Scheltinga M. Venous Side Branch Ligation as a First Step Treatment for Haemodialysis Access Induced Hand Ischaemia: Effects on Access Flow Volume and Digital Perfusion. Eur J Vasc Endovasc Surg. 2015;50:810-4 pubmed publisher
    ..a brachial artery based AVF were studied using a questionnaire quantifying hand ischemia, digital brachial index (DBI, finger plethysmography), and Duplex analysis...
  77. Alba M, Suarez C, Varela Y, Patarroyo M, Bermudez A, Patarroyo M. TCR-contacting residues orientation and HLA-DR?* binding preference determine long-lasting protective immunity against malaria. Biochem Biophys Res Commun. 2016;477:654-660 pubmed publisher
    ..5 Å ± 1.5 Å) between residues perfectly fitting into HLA-DR?1*PBR pockets 1 and 9, a gauche(-) rotamer orientation in p8 TCR-contacting polar residue and a larger volume of polar p2 ..
  78. Zhao L, Wang F, Weng X, Li R, Zhou X, Lin H, et al. Novel indicators for thermodynamic prediction of interfacial interactions related with adhesive fouling in a membrane bioreactor. J Colloid Interface Sci. 2017;487:320-329 pubmed publisher
    This study focused on developing indicators to predict adhesive membrane fouling in a membrane bioreactor (MBR)...
  79. Luo W, Phan H, Xie M, Hai F, Price W, Elimelech M, et al. Osmotic versus conventional membrane bioreactors integrated with reverse osmosis for water reuse: Biological stability, membrane fouling, and contaminant removal. Water Res. 2017;109:122-134 pubmed publisher
    ..of osmotic membrane bioreactor - reverse osmosis (OMBR-RO) and conventional membrane bioreactor - reverse osmosis (MBR-RO) for advanced wastewater treatment and water reuse...
  80. Notter T, Coughlin J, Sawa A, Meyer U. Reconceptualization of translocator protein as a biomarker of neuroinflammation in psychiatry. Mol Psychiatry. 2017;: pubmed publisher
    ..Positron emission tomography (PET) using radiolabeled ligands selective for the 18?kDa translocator protein (TSPO) has become the most widely used technique to assess putative neuroimmune abnormalities in vivo...
  81. Deussing M, Blume T, Vomacka L, Mahler C, Focke C, Todica A, et al. Coupling between physiological TSPO expression in brain and myocardium allows stabilization of late-phase cerebral [18F]GE180 PET quantification. Neuroimage. 2018;165:83-91 pubmed publisher
    PET imaging of the 18 kDa translocator protein (TSPO), a biomarker of microglial activity, receives growing interest in clinical and preclinical applications of neuroinflammatory and neurodegenerative brain diseases...
  82. Fuertes I, Gómez Lavín S, Elizalde M, Urtiaga A. Perfluorinated alkyl substances (PFASs) in northern Spain municipal solid waste landfill leachates. Chemosphere. 2017;168:399-407 pubmed publisher
    ..Two of the landfill sites applied on-site treatment using membrane bioreactors (MBR), and its effect on PFASs occurrence is also reported. Total PFASs (?PFASs) in raw leachates reached 1378...
  83. Joo H, Lee Y, Lim S, Lee E, Choi S, Cho E, et al. Peripheral benzodiazepine receptor regulates vascular endothelial activations via suppression of the voltage-dependent anion channel-1. FEBS Lett. 2012;586:1349-55 pubmed publisher
    Peripheral benzodiazepine receptor (PBR) is a multifunctional protein mainly found on the outer mitochondrial membrane. PBR expression is increased by tumor necrosis factor-? (TNF-?) in endothelial cells...
  84. Klubo Gwiezdzinska J, Jensen K, Bauer A, Patel A, Costello J, Burman K, et al. The expression of translocator protein in human thyroid cancer and its role in the response of thyroid cancer cells to oxidative stress. J Endocrinol. 2012;214:207-16 pubmed publisher
    The translocator protein (TSPO), formerly known as a peripheral benzodiazepine receptor, exerts pro-apoptotic function via regulation of mitochondrial membrane potential...
  85. Petibon Y, Guehl N, Reese T, Ebrahimi B, Normandin M, Shoup T, et al. Impact of motion and partial volume effects correction on PET myocardial perfusion imaging using simultaneous PET-MR. Phys Med Biol. 2017;62:326-343 pubmed publisher
    ..Myocardium-to-blood concentration ratios (MBR) and apparent wall thickness were calculated to assess image quality for static MPI...
  86. Bode J, Veenman L, Caballero B, Lakomek M, Kugler W, Gavish M. The 18 kDa translocator protein influences angiogenesis, as well as aggressiveness, adhesion, migration, and proliferation of glioblastoma cells. Pharmacogenet Genomics. 2012;22:538-50 pubmed publisher
    It is known that the mitochondrial 18 kDa translocator protein (TSPO) is present in almost all peripheral tissues and also in glial cells in the brain...
  87. Heintz S, Börner T, Ringborg R, Rehn G, Grey C, Nordblad M, et al. Development of in situ product removal strategies in biocatalysis applying scaled-down unit operations. Biotechnol Bioeng. 2017;114:600-609 pubmed publisher
    ..manual sample handling and to semi-automatically characterize ?-transaminases in a scaled-down packed-bed reactor (PBR) module, showing MPPA as a strong inhibitor...
  88. O Brien S, Cook A, Robinson R. Implicit assumptions underlying simple harvest models of marine bird populations can mislead environmental management decisions. J Environ Manage. 2017;201:163-171 pubmed publisher
    ..Potential Biological Removal (PBR) is a simple harvest model that estimates the number of additional mortalities that a population can theoretically ..
  89. Dev S, Roy S, Bhattacharya J. Optimization of the operation of packed bed bioreactor to improve the sulfate and metal removal from acid mine drainage. J Environ Manage. 2017;200:135-144 pubmed publisher
    The present study discusses the potentiality of using anaerobic Packed Bed Bioreactor (PBR) for the treatment of acid mine drainage (AMD)...
  90. Drira N, Dhouibi N, Hammami S, Piras A, Rosa A, Porcedda S, et al. Fatty acids from high rate algal pond's microalgal biomass and osmotic stress effects. Bioresour Technol. 2017;244:860-864 pubmed publisher
    ..This same wild biomass was cultivated in a photobioreactor (PBR) and the effect of osmotic stress was studied...
  91. Costa B, Salvetti A, Rossi L, Spinetti F, Lena A, Chelli B, et al. Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells. Mol Pharmacol. 2006;69:37-44 pubmed
    Peripheral benzodiazepine receptor (PBR) has been considered a promising drug target for cancer therapy, and several ligands have been developed for this purpose...
  92. Ujjainwala A, Courtney C, Rhoads S, Rhodes J, Christian C. Genetic loss of diazepam binding inhibitor in mice impairs social interest. Genes Brain Behav. 2017;: pubmed publisher
    ..The protein diazepam binding inhibitor (DBI) can act as an endogenous benzodiazepine, but a role for DBI in social behavior has not been described...