TSLP

Summary

Gene Symbol: TSLP
Description: thymic stromal lymphopoietin
Alias: thymic stromal lymphopoietin
Species: human
Products:     TSLP

Top Publications

  1. Liu Y. Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation. J Allergy Clin Immunol. 2007;120:238-44; quiz 245-6 pubmed
    It was demonstrated 5 years ago that thymic stromal lymphopoietin (TSLP), a IL-7-like cytokine produced by epithelial cells, could strongly activate human myeloid dendritic cells to induce an inflammatory T(H)2 response characterized by ..
  2. Ying S, O CONNOR B, Ratoff J, Meng Q, Fang C, Cousins D, et al. Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease. J Immunol. 2008;181:2790-8 pubmed
    ..The cytokine thymic stromal lymphopoietin (TSLP) promotes differentiation of Th2 T cells and secretion of chemokines which preferentially attract ..
  3. He J, Hallstrand T, Knight D, Chan Yeung M, Sandford A, Tripp B, et al. A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness. J Allergy Clin Immunol. 2009;124:222-9 pubmed publisher
    The epithelial cell-derived protein thymic stromal lymphopoietin stimulates dendritic and mast cells to promote proallergic T(H)2 responses...
  4. Smelter D, Sathish V, Thompson M, Pabelick C, Vassallo R, Prakash Y. Thymic stromal lymphopoietin in cigarette smoke-exposed human airway smooth muscle. J Immunol. 2010;185:3035-40 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is a newly identified IL-7-like cytokine known to be expressed in airway biopsies of patients with asthma and chronic obstructive pulmonary disease...
  5. Watanabe N, Hanabuchi S, Marloie Provost M, Antonenko S, Liu Y, Soumelis V. Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential. Blood. 2005;105:4749-51 pubmed
    ..We previously showed that human thymic stromal lymphopoietin (TSLP), highly expressed by keratinocytes of atopic dermatitis, activates CD11c(+) DCs to induce the ..
  6. Jessup H, Brewer A, Omori M, Rickel E, Budelsky A, Yoon B, et al. Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response. J Immunol. 2008;181:4311-9 pubmed
    The epithelial-derived cytokine thymic stromal lymphopoietin (TSLP) is sufficient to induce asthma or atopic dermatitis-like phenotypes when selectively overexpressed in transgenic mice, or when driven by topical application of vitamin D3 ..
  7. Lee K, Cho K, Kim J, Kim J, Baek J, Woo S, et al. Filaggrin knockdown and Toll-like receptor 3 (TLR3) stimulation enhanced the production of thymic stromal lymphopoietin (TSLP) from epidermal layers. Exp Dermatol. 2011;20:149-51 pubmed publisher
    ..keratinocytes, we transfected filaggrin siRNA into HaCaT human keratinocyte cells and determined that thymic stromal lymphopoietin (TSLP) and IL-6 secretion were increased by poly(I:C) stimulus...
  8. Yao W, Zhang Y, Jabeen R, Nguyen E, Wilkes D, Tepper R, et al. Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP. Immunity. 2013;38:360-72 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine important for the initiation and development of T helper (Th2) cell-mediated allergic inflammation...
  9. FERNANDEZ M, Heuzé M, Martinez Cingolani C, Volpe E, Donnadieu M, Piel M, et al. The human cytokine TSLP triggers a cell-autonomous dendritic cell migration in confined environments. Blood. 2011;118:3862-9 pubmed publisher
    ..In this study, we report the unexpected finding that the epithelial-derived cytokine TSLP triggers chemokinesis of resting primary human DCs in a cell-autonomous manner...

More Information

Publications69

  1. Rochman I, Watanabe N, Arima K, Liu Y, Leonard W. Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells. J Immunol. 2007;178:6720-4 pubmed
    b>Thymic stromal lymphopoietin (TSLP) is a cytokine that promotes CD4(+) T cell homeostasis and contributes to allergic and inflammatory responses...
  2. Hunninghake G, Soto Quiros M, Avila L, Kim H, Lasky Su J, Rafaels N, et al. TSLP polymorphisms are associated with asthma in a sex-specific fashion. Allergy. 2010;65:1566-75 pubmed publisher
    Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion...
  3. Ziegler S, Artis D. Sensing the outside world: TSLP regulates barrier immunity. Nat Immunol. 2010;11:289-93 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like cytokine originally characterized by its ability to promote the activation of B cells and dendritic cells (DCs)...
  4. Ziegler S, Liu Y. Thymic stromal lymphopoietin in normal and pathogenic T cell development and function. Nat Immunol. 2006;7:709-14 pubmed
    b>Thymic stromal lymphopoietin, a four helix-bundle cytokine, is expressed mainly by barrier epithelial cells and is a potent activator of several cell types, particularly myeloid dendritic cells...
  5. Torii Y, Ito T, Amakawa R, Sugimoto H, Amuro H, Tanijiri T, et al. Imidazoquinoline acts as immune adjuvant for functional alteration of thymic stromal lymphopoietin-mediated allergic T cell response. J Immunol. 2008;181:5340-9 pubmed
    ..Recently, it has been demonstrated that interaction between thymic stromal lymphopoietin (TSLP) and human DCs plays an essential role in evoking inflammatory Th2 responses in allergy through ..
  6. Zhu D, Zhu X, Jiang X, Dong Z. Thymic stromal lymphopoietin expression is increased in nasal epithelial cells of patients with mugwort pollen sensitive-seasonal allergic rhinitis. Chin Med J (Engl). 2009;122:2303-7 pubmed
    Excessive expression of thymic stromal lymphopoietin (TSLP) has been demonstrated in asthmatic airway epithelia and in nasal epithelia from animal models of allergic rhinitis (AR), but the evidence of expression of TSLP in nasal ..
  7. Mou Z, Xia J, Tan Y, Wang X, Zhang Y, Zhou B, et al. Overexpression of thymic stromal lymphopoietin in allergic rhinitis. Acta Otolaryngol. 2009;129:297-301 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) played an important role in the pathogenesis of allergic rhinitis (AR) and can be regarded a potential therapeutic target for the management of AR...
  8. Liu Y, Soumelis V, Watanabe N, Ito T, Wang Y, Malefyt R, et al. TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu Rev Immunol. 2007;25:193-219 pubmed
    ..Recent studies of TSLP (thymic stromal lymphopoietin), an epithelial cell-derived cytokine that strongly activates DCs, provide evidence at a molecular ..
  9. Hirano R, Hasegawa S, Hashimoto K, Haneda Y, Ohsaki A, Ichiyama T. Human thymic stromal lymphopoietin enhances expression of CD80 in human CD14+ monocytes/macrophages. Inflamm Res. 2011;60:605-10 pubmed publisher
    Human thymic stromal lymphopoietin (TSLP), an epithelial cell-derived cytokine, promotes inflammatory T helper type 2 cell (Th2) differentiation of naive CD4(+) T cells...
  10. Liu Y. TSLP in epithelial cell and dendritic cell cross talk. Adv Immunol. 2009;101:1-25 pubmed publisher
    ..Recent studies of TSLP (thymic stromal lymphopoietin), an epithelial cell-derived cytokine that strongly activates DCs, provide strong evidence at a ..
  11. Headley M, Zhou B, Shih W, Aye T, Comeau M, Ziegler S. TSLP conditions the lung immune environment for the generation of pathogenic innate and antigen-specific adaptive immune responses. J Immunol. 2009;182:1641-7 pubmed
    b>Thymic stromal lymphopoietin (TSLP) is crucial for the development of atopic diseases in humans and mice...
  12. Bhowmick S, Chatterjee D, Chaudhuri K. Human epithelial cells stimulated with Vibrio cholerae produce thymic stromal lymphopoietin and promote dendritic cell-mediated inflammatory Th2 response. Int J Biochem Cell Biol. 2012;44:1779-90 pubmed publisher
    ..An EC-derived cytokine thymic stromal lymphopoietin (TSLP) has been found a critical regulator of several human inflammatory conditions...
  13. He R, Geha R. Thymic stromal lymphopoietin. Ann N Y Acad Sci. 2010;1183:13-24 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine expressed in skin, gut, lungs, and thymus. TSLP signals via a TSLP receptor (TSLPR), a heterodimer of the IL-7 receptor alpha chain and the TSLPR chain...
  14. Shikotra A, Choy D, Ohri C, Doran E, Butler C, Hargadon B, et al. Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma. J Allergy Clin Immunol. 2012;129:104-11.e1-9 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is a cytokine implicated in the pathophysiology of asthma through 2 distinct pathways: a TSLP-OX40 ligand (OX40L)-T cell axis and a TSLP-mast cell axis...
  15. Bleck B, Tse D, Curotto de Lafaille M, Zhang F, Reibman J. Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturation and polarization via thymic stromal lymphopoietin. J Clin Immunol. 2008;28:147-56 pubmed
    ..We show that diesel exhaust particles upregulate thymic stromal lymphopoietin in human bronchial epithelial cells in an oxidant-dependent manner...
  16. Rothenberg M, Spergel J, Sherrill J, Annaiah K, Martin L, Cianferoni A, et al. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet. 2010;42:289-91 pubmed publisher
    ..We report association of EoE with variants at chromosome 5q22 encompassing TSLP and WDR36 (rs3806932, combined P = 3.19 x 10(-9))...
  17. Liu W, Xu L, Liu Q, Dong F, Qiu R, Wen M, et al. Two single nucleotide polymorphisms in TSLP gene are associated with asthma susceptibility in Chinese Han population. Exp Lung Res. 2012;38:375-82 pubmed publisher
    Asthma is a chronic inflammatory disease of the airway that is mediated by T-helper 2(TH2) cells. Thymic stromal lymphopoietin (TSLP) can aggravate asthmatic lung inflammation by activating dendritic cells (DCs) to promote TH2 ..
  18. Kinoshita H, Takai T, Le T, Kamijo S, Wang X, Ushio H, et al. Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J Allergy Clin Immunol. 2009;123:179-86 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) plays a key role in allergic diseases, such as atopic dermatitis (AD) and asthma...
  19. Semlali A, Jacques E, Koussih L, Gounni A, Chakir J. Thymic stromal lymphopoietin-induced human asthmatic airway epithelial cell proliferation through an IL-13-dependent pathway. J Allergy Clin Immunol. 2010;125:844-50 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) plays a pivotal role in the initiation of allergic airway inflammation. This cytokine is produced by several cell types, including human epithelial cells...
  20. Torgerson D, Ampleford E, Chiu G, Gauderman W, Gignoux C, Graves P, et al. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 2011;43:887-92 pubmed publisher
    ..We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in ..
  21. Yadava K, Sichelstiel A, Luescher I, Nicod L, Harris N, Marsland B. TSLP promotes influenza-specific CD8+ T-cell responses by augmenting local inflammatory dendritic cell function. Mucosal Immunol. 2013;6:83-92 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is a mucosal tissue-associated cytokine that has been widely studied in the context of T helper type 2 (Th2)-driven inflammatory disorders...
  22. Ziegler S, Roan F, Bell B, Stoklasek T, Kitajima M, Han H. The biology of thymic stromal lymphopoietin (TSLP). Adv Pharmacol. 2013;66:129-55 pubmed publisher
    Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic and nonhematopoietic cell lineages, including dendritic cells, basophils,..
  23. Harada M, Hirota T, Jodo A, Hitomi Y, Sakashita M, Tsunoda T, et al. Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma. Am J Respir Cell Mol Biol. 2011;44:787-93 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) triggers dendritic cell--mediated T helper (Th) 2 inflammatory responses...
  24. Ying S, O CONNOR B, Ratoff J, Meng Q, Mallett K, Cousins D, et al. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol. 2005;174:8183-90 pubmed
    b>Thymic stromal lymphopoietin (TSLP) is said to increase expression of chemokines attracting Th2 T cells...
  25. Lee E, Kim K, Hong J, Jee H, Sohn M, Kim K. Increased serum thymic stromal lymphopoietin in children with atopic dermatitis. Pediatr Allergy Immunol. 2010;21:e457-60 pubmed publisher
    The present study investigated the relationship between serum thymic stromal lymphopoietin (TSLP) levels and the presence and severity of atopic dermatitis (AD)...
  26. Gilliet M, Soumelis V, Watanabe N, Hanabuchi S, Antonenko S, de Waal Malefyt R, et al. Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells. J Exp Med. 2003;197:1059-63 pubmed
    Human thymic stromal lymphopoietin (TSLP) is a novel epithelial cell-derived cytokine, which induces dendritic cell (DC)-mediated CD4+ T cell responses with a proallergic phenotype...
  27. Liu M, Rogers L, Cheng Q, Shao Y, Fernandez Beros M, Hirschhorn J, et al. Genetic variants of TSLP and asthma in an admixed urban population. PLoS ONE. 2011;6:e25099 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP), an IL7-like cytokine produced by bronchial epithelial cells is upregulated in asthma and induces dendritic cell maturation supporting a Th2 response...
  28. Reche P, Soumelis V, Gorman D, Clifford T, Liu Mr -, Travis M, et al. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J Immunol. 2001;167:336-43 pubmed
    ..cytokine was discovered in a computational screen of genomic databases, and its homology to mouse thymic stromal lymphopoietin (TSLP) suggests that it is the human orthologue...
  29. Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Doi S, et al. Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. Nat Genet. 2011;43:893-6 pubmed publisher
    ..In addition to the major histocompatibility complex and TSLP-WDR36 loci previously reported, we identified three additional loci: a USP38-GAB1 locus on chromosome 4q31 (..
  30. Zhou B, Headley M, Aye T, Tocker J, Comeau M, Ziegler S. Reversal of thymic stromal lymphopoietin-induced airway inflammation through inhibition of Th2 responses. J Immunol. 2008;181:6557-62 pubmed
    Lung-specific thymic stromal lymphopoietin (TSLP) expression is sufficient for the development of an asthma-like chronic airway inflammatory disease...
  31. Ramasamy A, Curjuric I, Coin L, Kumar A, McArdle W, Imboden M, et al. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. J Allergy Clin Immunol. 2011;128:996-1005 pubmed publisher
    ..genes previously thought to be important, we found variants in 3 further genes that may be of interest: thymic stromal lymphopoietin (TSLP), Toll-like receptor 6 (TLR6) and nucleotide-binding oligomerization domain containing 1 (NOD1/..
  32. Allakhverdi Z, Comeau M, Jessup H, Yoon B, Brewer A, Chartier S, et al. Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J Exp Med. 2007;204:253-8 pubmed
    Compelling evidence suggests that the epithelial cell-derived cytokine thymic stromal lymphopoietin (TSLP) may initiate asthma or atopic dermatitis through a dendritic cell-mediated T helper (Th)2 response...
  33. Quentmeier H, Drexler H, Fleckenstein D, Zaborski M, Armstrong A, Sims J, et al. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. Leukemia. 2001;15:1286-92 pubmed
    b>Thymic stromal lymphopoietin (TSLP) is a novel cytokine that was found to promote the development of murine B cells in vitro. Here we describe the cloning and characterization of the human homologue of murine TSLP...
  34. Kashyap M, Rochman Y, Spolski R, Samsel L, Leonard W. Thymic stromal lymphopoietin is produced by dendritic cells. J Immunol. 2011;187:1207-11 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is a type 1 cytokine that contributes to lymphopoiesis and the development of asthma and atopic dermatitis...
  35. Soumelis V, Reche P, Kanzler H, Yuan W, Edward G, Homey B, et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol. 2002;3:673-80 pubmed
    ..We show here that human thymic stromal lymphopoietin (TSLP) potently activated CD11c(+) dendritic cells (DCs) and induced production of the T(H)2-attracting ..
  36. Arima K, Watanabe N, Hanabuchi S, Chang M, Sun S, Liu Y. Distinct signal codes generate dendritic cell functional plasticity. Sci Signal. 2010;3:ra4 pubmed publisher
    ..Here, we found that the cytokine thymic stromal lymphopoietin (TSLP) potently transduced a unique T helper type 2 (T(H)2)-inducing compound signal in DCs...
  37. Harada M, Hirota T, Jodo A, Doi S, Kameda M, Fujita K, et al. Functional analysis of the thymic stromal lymphopoietin variants in human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2009;40:368-74 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine that triggers dendritic cell-mediated T helper (Th)2 inflammatory responses, and is implicated in the pathogenesis of allergic diseases in humans...
  38. Liu Y. Thymic stromal lymphopoietin: master switch for allergic inflammation. J Exp Med. 2006;203:269-73 pubmed
    b>Thymic stromal lymphopoietin (TSLP) is an interleukin (IL) 7-like cytokine that triggers dendritic cell-mediated T helper (Th)2 inflammatory responses...
  39. Tanaka J, Watanabe N, Kido M, Saga K, Akamatsu T, Nishio A, et al. Human TSLP and TLR3 ligands promote differentiation of Th17 cells with a central memory phenotype under Th2-polarizing conditions. Clin Exp Allergy. 2009;39:89-100 pubmed publisher
    BACKGROUND" Human thymic stromal lymphopoietin (TSLP) is expressed in the human asthmatic lung and activates dendritic cells (DCs) to strongly induce proallergic T-helper type 2 (Th2) cell responses, suggesting that TSLP plays a ..
  40. Rochman Y, Leonard W. Thymic stromal lymphopoietin: a new cytokine in asthma. Curr Opin Pharmacol. 2008;8:249-54 pubmed publisher
    ..Following activation, these cells produce a wide range of cytokines including thymic stromal lymphopoietin (TSLP)...
  41. Ito T, Liu Y, Arima K. Cellular and molecular mechanisms of TSLP function in human allergic disorders--TSLP programs the "Th2 code" in dendritic cells. Allergol Int. 2012;61:35-43 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) has been recently implicated as a key molecule for initiating allergic inflammation at the epithelial cell-dendritic cell (DC) interface...
  42. Wang Y, Liu Y. Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses. Clin Exp Allergy. 2009;39:798-806 pubmed publisher
    ..Studies of thymic stromal lymphopoietin (TSLP), an epithelial cells-derived cytokine, that can strongly activate DCs, provide important ..
  43. Hunninghake G, Lasky Su J, Soto Quiros M, Avila L, Liang C, Lake S, et al. Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans. Am J Respir Crit Care Med. 2008;177:830-6 pubmed publisher
    ..An analysis of the association between single-nucleotide polymorphisms in thymic stromal lymphopoietin (TSLP) and IgE measurements was conducted in 417 parent-child trios in Costa Rica...
  44. Rochman Y, Kashyap M, Robinson G, Sakamoto K, Gomez Rodriguez J, Wagner K, et al. Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. Proc Natl Acad Sci U S A. 2010;107:19455-60 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is a type I cytokine that plays essential roles in allergic/inflammatory skin and airway disorders, in helminth infections, and in regulating intestinal immunity...
  45. Wang Y, Angkasekwinai P, Lu N, Voo K, Arima K, Hanabuchi S, et al. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med. 2007;204:1837-47 pubmed
    ..promotes cell expansion and Th2 cytokine production when Th2 central memory cells are stimulated with thymic stromal lymphopoietin (TSLP)-activated dendritic cells (DCs), homeostatic cytokines, or T cell receptor for antigen ..
  46. Di Claudio F, Muglia C, Smaldini P, Orsini Delgado M, Trejo F, Grigera J, et al. Use of a Collagen Membrane to Enhance the Survival of Primary Intestinal Epithelial Cells. J Cell Physiol. 2017;232:2489-2496 pubmed publisher
    ..The secretion of the homeostatic (IL-25 and TSLP), inhibitory (IL-10 and TGF-?), or pro-inflammatory mediators (IL-1? and TNF) were induced...
  47. Mahmutovic Persson I, Akbarshahi H, Menzel M, Brandelius A, Uller L. Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation. J Transl Med. 2016;14:52 pubmed publisher
    ..Lung homogenates were analysed for mRNA expression (RT-qPCR) of TNF-α, CCL2, CCL5, IL-1β, IL-33, thymic stromal lymphopoietin (TSLP), and IL-25 as well as pattern recognition receptors (PRRs) RIG-I, MDA5 and TLR3...
  48. Fahey L, Chandramouleeswaran P, Guan S, Benitez A, Furuta G, Aceves S, et al. Food allergen triggers are increased in children with the TSLP risk allele and eosinophilic esophagitis. Clin Transl Gastroenterol. 2018;9:139 pubmed publisher
    b>TSLP has been shown to be associated with eosinophilic esophagitis (EoE). Specifically, children with EoE often have the nucleotides AA or AG instead of GG at the single nucleotide polymorphism position RS3806932...
  49. Gela A, Bhongir R, Mori M, Keenan P, Morgelin M, Erjefalt J, et al. Osteopontin That Is Elevated in the Airways during COPD Impairs the Antibacterial Activity of Common Innate Antibiotics. PLoS ONE. 2016;11:e0146192 pubmed publisher
    ..secretory leukocyte peptidase inhibitor (SLPI), midkine, human beta defensin-3 (hBD-3), and thymic stromal lymphopoietin (TSLP) but showed low or no affinity for lysozyme and LL-37...
  50. Angelova Fischer I, Fernández I, Donnadieu M, Bulfone Paus S, Zillikens D, Fischer T, et al. Injury to the stratum corneum induces in vivo expression of human thymic stromal lymphopoietin in the epidermis. J Invest Dermatol. 2010;130:2505-7 pubmed publisher
  51. Usategui A, Criado G, Izquierdo E, del Rey M, Carreira P, Ortiz P, et al. A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis. Ann Rheum Dis. 2013;72:2018-23 pubmed publisher
    ..We have analysed the expression and function of thymic stromal lymphopoietin (TSLP), a central regulator of Th2-mediated allergic inflammation, in human SSc, primary lung fibrosis ..
  52. Froidure A, Shen C, Gras D, Van Snick J, Chanez P, Pilette C. Myeloid dendritic cells are primed in allergic asthma for thymic stromal lymphopoietin-mediated induction of Th2 and Th9 responses. Allergy. 2014;69:1068-76 pubmed publisher
    ..To evaluate whether mDCs from AA patients are primed for thymic stromal lymphopoietin (TSLP)-driven responses...
  53. Wang J, Xing F. Human TSLP-educated DCs. Cell Mol Immunol. 2008;5:99-106 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP), an IL-7-related cytokine, is widely expressed by epithelial cells in many tissues with different biological effects...
  54. Yi L, Cheng D, Zhang K, Huo X, Mo Y, Shi H, et al. Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis. Mucosal Immunol. 2017;10:1491-1503 pubmed publisher
    The epithelial and epidermal innate cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) have pivotal roles in the initiation of allergic inflammation in asthma and atopic dermatitis (AD)...
  55. Bae C, Choi Y, Song S, Kim Y. Effect of thymic stromal lymphopoietin on MUC5B expression in human airway epithelial cells. Biochem Biophys Res Commun. 2014;448:231-5 pubmed publisher
    b>Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine and a potent factor for B- and T-cell growth and differentiation. Recent studies have demonstrated an association of TSLP with allergic and inflammatory airway diseases...
  56. Zhang K, Shan L, Rahman M, Unruh H, Halayko A, Gounni A. Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2007;293:L375-82 pubmed
    b>Thymic stromal lymphopoietin (TSLP) is a novel cytokine that triggers dendritic cell-mediated T helper (Th)-2 inflammatory responses...
  57. Park J, Jeong D, Peyrin Biroulet L, Eisenhut M, Shin J. Insight into the role of TSLP in inflammatory bowel diseases. Autoimmun Rev. 2017;16:55-63 pubmed publisher
    ..b>Thymic stromal lymphopoietin (TSLP), which has been studied in various allergic diseases such as asthma, atopic dermatitis (AD) and ..
  58. Wang B, Liu F, Dong J, You M, Fu Y, Li C, et al. Maternal exposure to environmental DEHP exacerbated OVA-induced asthmatic responses in rat offspring. Sci Total Environ. 2018;615:253-261 pubmed publisher
    ..lung pathological changes were observed, Th2 type cytokines expressions were checked, and the expression of TSLP signaling pathway were examined...
  59. Hanabuchi S, Ito T, Park W, Watanabe N, Shaw J, Roman E, et al. Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus. J Immunol. 2010;184:2999-3007 pubmed publisher
    ..We previously showed that mDCs, educated by thymic stromal lymphopoietin (TSLP) produced by the epithelial cells of the Hassall's corpuscles, induced differentiation of CD4(+)..
  60. Chai R, Liu B, Qi F. The significance of the levels of IL-4, IL-31 and TLSP in patients with asthma and/or rhinitis. Immunotherapy. 2017;9:331-337 pubmed publisher
    To investigate the clinical significance of the levels of IL-4, IL-33 and thymic stromal lymphopoietin (TLSP) in patients with asthma and/or rhinitis, then do the simple verification in animals...