TSLC1

Summary

Gene Symbol: TSLC1
Description: cell adhesion molecule 1
Alias: BL2, IGSF4, IGSF4A, NECL2, Necl-2, RA175, ST17, SYNCAM, TSLC1, sTSLC-1, sgIGSF, synCAM1, cell adhesion molecule 1, TSLC-1, TSLC1/Nectin-like 2/IGSF4, immunoglobulin superfamily member 4, immunoglobulin superfamily, member 4D variant 1, immunoglobulin superfamily, member 4D variant 2, nectin-like 2, nectin-like protein 2, spermatogenic immunoglobulin superfamily, synaptic cell adhesion molecule, truncated CADM1 protein, tumor suppressor in lung cancer 1
Species: human
Products:     TSLC1

Top Publications

  1. Allinen M, Peri L, Kujala S, Lahti Domenici J, Outila K, Karppinen S, et al. Analysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: indications of TSLC1 promoter hypermethylation. Genes Chromosomes Cancer. 2002;34:384-9 pubmed
    ..We examined 31 primary breast tumors showing LOH in 11q21-24 for mutations in the MRE11A, CHK1, PPP2R1B, and TSLC1 genes...
  2. Boles K, Barchet W, Diacovo T, Cella M, Colonna M. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. Blood. 2005;106:779-86 pubmed
    The tumor suppressor in lung cancer-1 (TSLC1) gene is frequently silenced in human lung carcinomas, and its expression suppresses tumorigenesis in nude mice...
  3. Yang W, Kaur D, Okayama Y, Ito A, Wardlaw A, Brightling C, et al. Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. J Immunol. 2006;176:1238-43 pubmed
    ..This supports the hypothesis that adhesion is important in the recruitment and retention of HLMC by the ASM in asthma, and for the functional interaction of these cells. ..
  4. Ito A, Okada M, Uchino K, Wakayama T, Koma Y, Iseki S, et al. Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma. Lab Invest. 2003;83:1175-83 pubmed
    b>TSLC1 (tumor suppressor in lung cancer-1) is an adhesion molecule of the Ig superfamily that binds homophilically and mediates cell-cell interactions...
  5. Inoue T, Hagiyama M, Yoneshige A, Kato T, Enoki E, Maenishi O, et al. Increased ectodomain shedding of cell adhesion molecule 1 from pancreatic islets in type 2 diabetic pancreata: correlation with hemoglobin A1c levels. PLoS ONE. 2014;9:e100988 pubmed publisher
    ..Respectively, the diseases affect lung alveolar and pancreatic islet cells, which express cell adhesion molecule 1 (CADM1), an immunoglobulin superfamily member...
  6. Nowacki S, Skowron M, Oberthuer A, Fagin A, Voth H, Brors B, et al. Expression of the tumour suppressor gene CADM1 is associated with favourable outcome and inhibits cell survival in neuroblastoma. Oncogene. 2008;27:3329-38 pubmed
    b>Cell adhesion molecule 1 (CADM1) is a putative tumour suppressor gene, which is downregulated in many solid tumours...
  7. Shingai T, Ikeda W, Kakunaga S, Morimoto K, Takekuni K, Itoh S, et al. Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. J Biol Chem. 2003;278:35421-7 pubmed
    ..nectins, have been identified, and we characterized here nectin-like molecule-2 (Necl-2)/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1. Necl-2 showed Ca2+-independent homophilic cell-cell adhesion activity...
  8. Mao X, Seidlitz E, Truant R, Hitt M, Ghosh H. Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth. Oncogene. 2004;23:5632-42 pubmed
    The TSLC1 tumor-suppressor gene is silenced in a number of human cancer tissues and cell lines, including lung, prostate, liver, stomach, pancreatic, and breast cancers...
  9. Ito A, Nishikawa Y, Ohnuma K, Ohnuma I, Koma Y, Sato A, et al. SgIGSF is a novel biliary-epithelial cell adhesion molecule mediating duct/ductule development. Hepatology. 2007;45:684-94 pubmed
    b>Spermatogenic immunoglobulin superfamily (SgIGSF) is an intercellular adhesion molecule of the nectin-like family. While screening its tissue distribution, we found that it was expressed in fetal liver but not adult liver...

More Information

Publications70

  1. Hasstedt S, Bezemer I, Callas P, Vossen C, Trotman W, Hebbel R, et al. Cell adhesion molecule 1: a novel risk factor for venous thrombosis. Blood. 2009;114:3084-91 pubmed publisher
    ..polymorphisms in 6 genes tested in the larger family set, only single nucleotide polymorphisms in cell adhesion molecule 1 (CADM1) associated with VT...
  2. Biederer T, Sara Y, Mozhayeva M, Atasoy D, Liu X, Kavalali E, et al. SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science. 2002;297:1525-31 pubmed
    ..We now show that SynCAM is a brain-specific, immunoglobulin domain-containing protein that binds to intracellular PDZ-domain proteins and ..
  3. Moiseeva E, Roach K, Leyland M, Bradding P. CADM1 is a key receptor mediating human mast cell adhesion to human lung fibroblasts and airway smooth muscle cells. PLoS ONE. 2013;8:e61579 pubmed publisher
    ..The differential expression of CADM1 counter-receptors on HLFs compared to HASMCs may allow the specific targeting of either HLMC-HLF or HLMC-HASMC interactions in the lung parenchyma and airways. ..
  4. Fukami T, Fukuhara H, Kuramochi M, Maruyama T, Isogai K, Sakamoto M, et al. Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines. Int J Cancer. 2003;107:53-9 pubmed
    We previously identified TSLC1, a tumor suppressor gene in human nonsmall cell lung cancer (NSCLC). TSLC1 belongs to immunoglobulin superfamily molecules and is involved in cell adhesion...
  5. Minami A, Shimono Y, Mizutani K, Nobutani K, Momose K, Azuma T, et al. Reduction of the ST6 ?-galactosamide ?-2,6-sialyltransferase 1 (ST6GAL1)-catalyzed sialylation of nectin-like molecule 2/cell adhesion molecule 1 and enhancement of ErbB2/ErbB3 signaling by microRNA-199a. J Biol Chem. 2013;288:11845-53 pubmed publisher
    Nectin-like molecule 2 (Necl-2)/cell adhesion molecule 1 (CADM1) is shown to be down-regulated by the promoter hypermethylation and/or loss of heterozygosity at chromosome 11q23...
  6. Lung H, Cheung A, Xie D, Cheng Y, Kwong F, Murakami Y, et al. TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma. Cancer Res. 2006;66:9385-92 pubmed
    ..In up to 87% of nasopharyngeal carcinoma (NPC) clinical tumor specimens, there was either down-regulation or loss of TSLC1 gene expression...
  7. Sussan T, Pletcher M, Murakami Y, Reeves R. Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression. Mol Cancer. 2005;4:28 pubmed
    Introduction of cDNA or genomic clones of the tumor suppressor in lung cancer 1 (TSLC1) gene into the non-small cell lung cancer line, A549, reverses tumorigenic growth properties of these cells...
  8. Overmeer R, Henken F, Snijders P, Claassen Kramer D, Berkhof J, Helmerhorst T, et al. Association between dense CADM1 promoter methylation and reduced protein expression in high-grade CIN and cervical SCC. J Pathol. 2008;215:388-97 pubmed publisher
    We previously showed that silencing of TSLC1, recently renamed CADM1, is functionally involved in high-risk HPV-mediated cervical carcinogenesis. CADM1 silencing often results from promoter methylation...
  9. Steenbergen R, Kramer D, Braakhuis B, Stern P, Verheijen R, Meijer C, et al. TSLC1 gene silencing in cervical cancer cell lines and cervical neoplasia. J Natl Cancer Inst. 2004;96:294-305 pubmed
    ..We assessed the role of the gene encoding the adhesion molecule tumor suppressor in lung cancer 1 (TSLC1) in this progression...
  10. Kikuchi S, Iwai M, Sakurai Yageta M, Tsuboi Y, Ito T, Maruyama T, et al. Expression of a splicing variant of the CADM1 specific to small cell lung cancer. Cancer Sci. 2012;103:1051-7 pubmed publisher
    ..These findings suggest that CADM1 enhances the malignant features of SCLC, as is observed in ATL, and could provide a molecular marker specific to SCLC. ..
  11. Mao X, Seidlitz E, Ghosh K, Murakami Y, Ghosh H. The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer. Cancer Res. 2003;63:7979-85 pubmed
    The tumor suppressor gene in lung cancer (TSLC1) encodes a membrane glycoprotein containing extensive homology in the extracellular domain with the immunoglobulin-superfamily cell adhesion molecules...
  12. Momose K, Minami A, Shimono Y, Mizutani K, Nobutani K, Azuma T, et al. miR-214 and hypoxia down-regulate Necl-2/CADM1 and enhance ErbB2/ErbB3 signaling. Genes Cells. 2013;18:195-202 pubmed publisher
    ..These results indicate that miR-214 and hypoxia are novel regulators that down-regulate Necl-2 and enhance ErbB2/ErbB3 signaling. ..
  13. Fukuhara H, Masuda M, Yageta M, Fukami T, Kuramochi M, Maruyama T, et al. Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg. Oncogene. 2003;22:6160-5 pubmed
    We have previously identified the tumor suppressor in lung cancer 1 (TSLC1) gene as a novel tumor suppressor in human non-small cell lung cancer (NSCLC) by functional complementation...
  14. Berginc G, Bracko M, Glavac D. MS-MLPA reveals progressive age-dependent promoter methylation of tumor suppressor genes and possible role of IGSF4 gene in colorectal carcinogenesis of microsatellite instable tumors. Cancer Invest. 2010;28:94-102 pubmed publisher
    ..CpG methylation was detected in 12 tumor suppressor genes. Our findings suggest a potential role of IGSF4 gene in the development of colorectal tumors...
  15. Liang Q, Chen G, Li Z, Wang B. Function and histopathology of a cell adhesion molecule TSLC1 in cancer. Cancer Invest. 2011;29:107-12 pubmed
    Even less than a decade since the discovery of TSLC1, overwhelming evidence demonstrates that the loss of TSLC1 expression by methylation-mediated epigenetic silencing or LOH is crucially implicated in various processes during ..
  16. Masuda M, Yageta M, Fukuhara H, Kuramochi M, Maruyama T, Nomoto A, et al. The tumor suppressor protein TSLC1 is involved in cell-cell adhesion. J Biol Chem. 2002;277:31014-9 pubmed
    b>TSLC1 is a tumor suppressor gene encoding a member of the immunoglobulin (Ig) superfamily...
  17. Faraji F, Pang Y, Walker R, Nieves Borges R, Yang L, Hunter K. Cadm1 is a metastasis susceptibility gene that suppresses metastasis by modifying tumor interaction with the cell-mediated immunity. PLoS Genet. 2012;8:e1002926 pubmed publisher
  18. Chen P, Yeh S, Liu W, Lin C, Huang H, Chen C, et al. Androgen pathway stimulates microRNA-216a transcription to suppress the tumor suppressor in lung cancer-1 gene in early hepatocarcinogenesis. Hepatology. 2012;56:632-43 pubmed publisher
    ..One target of miR-216a was shown to be the tumor suppressor in lung cancer-1 gene (TSLC1) messenger RNA (mRNA) through the three target sites at its 3' untranslated region...
  19. Sasaki H, Nishikata I, Shiraga T, Akamatsu E, Fukami T, Hidaka T, et al. Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia. Blood. 2005;105:1204-13 pubmed
    ..alpha were up-regulated more than 2-fold compared with CD4(+) and CD4(+)CD45RO(+) T cells, and tumor suppressor in lung cancer 1 (TSLC1), caveolin 1, and prostaglandin D2 synthase showed increased expression of more than 30-fold...
  20. Mizutani K, Kawano S, Minami A, Waseda M, Ikeda W, Takai Y. Interaction of nectin-like molecule 2 with integrin alpha6beta4 and inhibition of disassembly of integrin alpha6beta4 from hemidesmosomes. J Biol Chem. 2011;286:36667-76 pubmed publisher
    ..These results indicate that tumor-suppressive functions of Necl-2 are mediated by the stabilization of the hemidesmosome structure in addition to the inhibition of the ErbB3/ErbB2 signaling...
  21. Li Q, Zhou L, Yang F, Wang G, Zheng H, Wang D, et al. MicroRNA-10b promotes migration and invasion through CADM1 in human hepatocellular carcinoma cells. Tumour Biol. 2012;33:1455-65 pubmed publisher
    ..These results suggest that miR-10b may positively regulate the invasion and metastasis of HCC through targeting CADM1. ..
  22. Mazumder Indra D, Mitra S, Roy A, Mondal R, Basu P, Roychoudhury S, et al. Alterations of ATM and CADM1 in chromosomal 11q22.3-23.2 region are associated with the development of invasive cervical carcinoma. Hum Genet. 2011;130:735-48 pubmed publisher
    ..Thus, our data suggest that inactivation of ATM-CHEK1-associated DNA damage response pathway and CADM1-associated signaling network might have an important role in the development of CACX. ..
  23. Murakami S, Sakurai Yageta M, Maruyama T, Murakami Y. Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg. PLoS ONE. 2014;9:e82894 pubmed publisher
    CADM1 (Cell adhesion molecule 1), a cell adhesion molecule belonging to the immunoglobulin superfamily, is involved in cell-cell interaction and the formation and maintenance of epithelial structure...
  24. Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, et al. Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J Immunol. 2008;181:2772-80 pubmed
    ..Targeting these interactions in asthma might offer a new strategy for the treatment of this common disease. ..
  25. Liu Z, Zhu L, Qin H, Li D, Xie Z, Ke X, et al. Re-expression of cell adhesion molecule inhibits growth and induces apoptosis of human pancreatic cancer cell line PANC-1. J Huazhong Univ Sci Technolog Med Sci. 2011;31:762-767 pubmed publisher
    This study examined the expression of cell adhesion molecule 1 (CADM1) in pancreatic cancer and the possible mechanism...
  26. Kuipers J, Coenen E, Balgobind B, Stary J, Baruchel A, de Haas V, et al. High IGSF4 expression in pediatric M5 acute myeloid leukemia with t(9;11)(p22;q23). Blood. 2011;117:928-35 pubmed publisher
    ..b>IGSF4, a cell-cell adhesion molecule, was found to be highly expressed in t(9;11)(p22;q23) patients, which was confirmed ..
  27. He G, Lei W, Wang S, Xiao R, Guo K, Xia Y, et al. Overexpression of tumor suppressor TSLC1 by a survivin-regulated oncolytic adenovirus significantly inhibits hepatocellular carcinoma growth. J Cancer Res Clin Oncol. 2012;138:657-70 pubmed publisher
    ..b>TSLC1, a novel tumor suppressor gene, was loss in many human cancers including HCC, not in normal cells...
  28. Dewan M, Takamatsu N, Hidaka T, Hatakeyama K, Nakahata S, Fujisawa J, et al. Critical role for TSLC1 expression in the growth and organ infiltration of adult T-cell leukemia cells in vivo. J Virol. 2008;82:11958-63 pubmed publisher
    ..The tumor suppressor lung cancer 1 (TSLC1) gene was previously identified as a novel cell surface marker for ATL, and this study demonstrated the ..
  29. Biederer T. Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules. Genomics. 2006;87:139-50 pubmed
    SynCAM 1 (synaptic cell adhesion molecule 1, alternatively named Tslc1 and nectin-like protein 3) belongs to the immunoglobulin superfamily and is an adhesion molecule that operates in a variety of important contexts...
  30. Uchino K, Ito A, Wakayama T, Koma Y, Okada T, Ohbayashi C, et al. Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung. Cancer. 2003;98:1002-7 pubmed
    Recently, the TSLC1 (tumor suppressor in lung cancer 1) gene has been identified as a novel tumor suppressor in human nonsmall cell lung carcinoma...
  31. Fukuhara H, Kuramochi M, Fukami T, Kasahara K, Furuhata M, Nobukuni T, et al. Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer. Jpn J Cancer Res. 2002;93:605-9 pubmed
    We recently identified TSLC1, a tumor suppressor gene in human lung cancer. Gene silencing by promoter methylation has been observed frequently in adenocarcinoma of the lung, liver, and pancreas...
  32. Nakahata S, Morishita K. CADM1/TSLC1 is a novel cell surface marker for adult T-cell leukemia/lymphoma. J Clin Exp Hematop. 2012;52:17-22 pubmed
    CADM1/TSLC1 (Cell adhesion molecule 1/Tumor suppressor in lung cancer 1) is a cell adhesion molecule that was originally identified as a tumor suppressor in lung cancer...
  33. Moiseeva E, Leyland M, Bradding P. CADM1 is expressed as multiple alternatively spliced functional and dysfunctional isoforms in human mast cells. Mol Immunol. 2013;53:345-54 pubmed publisher
    b>Cell adhesion molecule 1 (CADM1) is implicated in the pathogenesis of several diseases and is responsible for adhesion and survival of mast cells (MCs). Differential expression of CADM1 isoforms was found in different species...
  34. Zhiling Y, Fujita E, Tanabe Y, Yamagata T, Momoi T, Momoi M. Mutations in the gene encoding CADM1 are associated with autism spectrum disorder. Biochem Biophys Res Commun. 2008;377:926-9 pubmed publisher
    ..RA175/SynCAM1/CADM1(CADM1), a member of immunoglobulin superfamily, is another synaptic cell adhesion molecule. To clarify the idea that impaired synaptogenesis underlies the pathogenesis of ASD, we examined the ..
  35. Sakurai Yageta M, Masuda M, Tsuboi Y, Ito A, Murakami Y. Tumor suppressor CADM1 is involved in epithelial cell structure. Biochem Biophys Res Commun. 2009;390:977-82 pubmed publisher
    ..These findings suggest that CADM1 is involved in the formation of epithelia-like cell structure with 4.1B and MPP2, while loss of its function could cause morphological transformation of cancer cells. ..
  36. Kawano S, Ikeda W, Kishimoto M, Ogita H, Takai Y. Silencing of ErbB3/ErbB2 signaling by immunoglobulin-like Necl-2. J Biol Chem. 2009;284:23793-805 pubmed publisher
    ..We describe here this novel mechanism for silencing of the ErbB3/ErbB2 signaling by Necl-2. ..
  37. Hui A, Lo K, Kwong J, Lam E, Chan S, Chow L, et al. Epigenetic inactivation of TSLC1 gene in nasopharyngeal carcinoma. Mol Carcinog. 2003;38:170-8 pubmed
    ..b>TSLC1 (tumor suppressor in lung cancer) is recently reported to be a putative TSG on 11q23...
  38. Galibert L, Diemer G, Liu Z, Johnson R, Smith J, Walzer T, et al. Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. J Biol Chem. 2005;280:21955-64 pubmed
    ..We demonstrate that anti-1F12 scFv binds Nectin-like protein 2 (Necl2, Tslc1, SynCaM, SgIGSF, or Igsf4), an adhesion molecule involved in tumor suppression, synapse formation, and spermatogenesis...
  39. Overmeer R, Louwers J, Meijer C, van Kemenade F, Hesselink A, Daalmeijer N, et al. Combined CADM1 and MAL promoter methylation analysis to detect (pre-)malignant cervical lesions in high-risk HPV-positive women. Int J Cancer. 2011;129:2218-25 pubmed publisher
    ..Here, we tested whether combined methylation analysis for cell adhesion molecule 1 (CADM1) and T-lymphocyte maturation associated protein (MAL), both functionally involved in cervical ..
  40. Ito T, Shimada Y, Hashimoto Y, Kaganoi J, Kan T, Watanabe G, et al. Involvement of TSLC1 in progression of esophageal squamous cell carcinoma. Cancer Res. 2003;63:6320-6 pubmed
    ..b>TSLC1 was identified on chromosome 11q23...
  41. Surace E, Lusis E, Murakami Y, Scheithauer B, Perry A, Gutmann D. Loss of tumor suppressor in lung cancer-1 (TSLC1) expression in meningioma correlates with increased malignancy grade and reduced patient survival. J Neuropathol Exp Neurol. 2004;63:1015-27 pubmed
    ..1B genes. Recently, 4.1B was shown to interact with the tumor suppressor in lung cancer-1 (TSLC1) protein, prompting us to examine the expression of TSLC1 in meningiomas...
  42. Chen K, Wang G, Peng L, Liu S, Fu X, Zhou Y, et al. CADM1/TSLC1 inactivation by promoter hypermethylation is a frequent event in colorectal carcinogenesis and correlates with late stages of the disease. Int J Cancer. 2011;128:266-73 pubmed publisher
    b>Cell adhesion molecule 1 (CADM1/TSLC1), a putative tumor suppressor involving in cell adhesion, proliferation and apoptosis, is frequently inactivated in several carcinomas due to promoter hypermethylation...
  43. van den Berg R, Snijders P, Grunberg K, Kooi C, Spreeuwenberg M, Meijer C, et al. Comprehensive CADM1 promoter methylation analysis in NSCLC and normal lung specimens. Lung Cancer. 2011;72:316-21 pubmed publisher
    ..Hence, CADM1 methylation analysis is unlikely to have diagnostic value for the early detection of lung cancer in an unselected population. However, a diagnostic value for selected subjects, such as females, cannot be excluded. ..
  44. Zhang W, Zhou L, Ding S, Xie H, Xu X, Wu J, et al. Aberrant methylation of the CADM1 promoter is associated with poor prognosis in hepatocellular carcinoma treated with liver transplantation. Oncol Rep. 2011;25:1053-62 pubmed publisher
    ..The aim of the present study was to investigate the methylation status and expression levels of cell adhesion molecule 1 (CADM1) in HCC; to elucidate its regulation mechanisms; and finally, to evaluate the potential predictive ..
  45. Mimae T, Hagiyama M, Inoue T, Yoneshige A, Kato T, Okada M, et al. Increased ectodomain shedding of lung epithelial cell adhesion molecule 1 as a cause of increased alveolar cell apoptosis in emphysema. Thorax. 2014;69:223-31 pubmed publisher
    ..b>Cell adhesion molecule 1 (CADM1) is a lung epithelial cell adhesion molecule in the immunoglobulin superfamily...
  46. Honda T, Tamura G, Waki T, Jin Z, Sato K, Motoyama T, et al. Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines. Jpn J Cancer Res. 2002;93:857-60 pubmed
    The TSLC1 (tumor suppressor in lung cancer-1) gene is a novel tumor suppressor gene on chromosomal region 11q23...
  47. Watabe K, Ito A, Koma Y, Kitamura Y. IGSF4: a new intercellular adhesion molecule that is called by three names, TSLC1, SgIGSF and SynCAM, by virtue of its diverse function. Histol Histopathol. 2003;18:1321-9 pubmed publisher
    ..has been characterized by several independent research groups, this molecule is called by three names, TSLC1, SgIGSF and SynCAM...
  48. Takahashi Y, Iwai M, Kawai T, Arakawa A, Ito T, Sakurai Yageta M, et al. Aberrant expression of tumor suppressors CADM1 and 4.1B in invasive lesions of primary breast cancer. Breast Cancer. 2012;19:242-52 pubmed publisher
    The tumor suppressor genes CADM1/TSLC1 and DAL-1/4.1B are frequently inactivated by promoter methylation in non-small cell lung cancer. The proteins they encode, CADM1 and 4...
  49. Murray P, Fan Y, Davies G, Ying J, Geng H, Ng K, et al. Epigenetic silencing of a proapoptotic cell adhesion molecule, the immunoglobulin superfamily member IGSF4, by promoter CpG methylation protects Hodgkin lymphoma cells from apoptosis. Am J Pathol. 2010;177:1480-90 pubmed publisher
    ..b>IGSF4/CADM1/TSLC1, a pro-apoptotic cell adhesion molecule of the immunoglobulin superfamily, was identified together ..
  50. Yageta M, Kuramochi M, Masuda M, Fukami T, Fukuhara H, Maruyama T, et al. Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer. Cancer Res. 2002;62:5129-33 pubmed
    The tumor suppressor gene TSLC1, which we recently identified in human non-small cell lung cancer, encodes a membrane glycoprotein of the immunoglobulin superfamily...
  51. Moiseeva E, Leyland M, Bradding P. CADM1 isoforms differentially regulate human mast cell survival and homotypic adhesion. Cell Mol Life Sci. 2012;69:2751-64 pubmed publisher
    b>Cell adhesion molecule 1 (CADM1), expressed by human lung mast cells (HLMCs), mediates their adhesion to airway smooth muscle (ASM), and contributes to ASM-dependent HLMC proliferation and survival...
  52. Koma Y, Furuno T, Hagiyama M, Hamaguchi K, Nakanishi M, Masuda M, et al. Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions. Gastroenterology. 2008;134:1544-54 pubmed publisher
    b>Cell adhesion molecule 1 (CADM1), mediates nerve-mast cell attachment and communication through homophilic binding. An immunohistochemical screen showed that CADM1 is expressed in pancreatic islets...
  53. Gomyo H, Arai Y, Tanigami A, Murakami Y, Hattori M, Hosoda F, et al. A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2. Genomics. 1999;62:139-46 pubmed
    ..The novel gene, which we call IGSF4 (immunoglobulin superfamily 4), is transcribed into a 1.6- or 4.4-kb RNA encoding a 442-amino-acid protein...
  54. Giangreco A, Jensen K, Takai Y, Miyoshi J, Watt F. Necl2 regulates epidermal adhesion and wound repair. Development. 2009;136:3505-14 pubmed publisher
    ..We show that the intercellular adhesion protein nectin-like molecule 2 (Necl2) is highly expressed in bulge stem cells of adult human and mouse hair follicles...
  55. Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, et al. CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells. J Biol Chem. 2010;285:15511-22 pubmed publisher
    ..Our results indicate that Tiam1 integrates signals from CADM1 to regulate the actin cytoskeleton through Rac activation, which may lead to tissue infiltration of leukemic cells in ATL patients. ..
  56. Furuno T, Ito A, Koma Y, Watabe K, Yokozaki H, Bienenstock J, et al. The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves. J Immunol. 2005;174:6934-42 pubmed
    ..The molecules that sustain this association have not been identified. Because synaptic cell adhesion molecule (SynCAM), alternatively named spermatogenic Ig superfamily (SgIGSF), is expressed on both nerves and ..
  57. Heller G, Geradts J, Ziegler B, Newsham I, Filipits M, Markis Ritzinger E, et al. Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. Breast Cancer Res Treat. 2007;103:283-91 pubmed
    b>TSLC1 and DAL-1 are tumor suppressor genes involved in cell adhesion. In this study, we examined the expression and methylation pattern of these genes in breast cancer cell lines and primary breast carcinomas...
  58. Yang G, He W, Cai M, Luo F, Kung H, Guan X, et al. Loss/Down-regulation of tumor suppressor in lung cancer 1 expression is associated with tumor progression and is a biomarker of poor prognosis in ovarian carcinoma. Int J Gynecol Cancer. 2011;21:486-93 pubmed publisher
    The tumor suppressor in lung cancer 1 (TSLC1) has been identified as a putative tumor suppressor gene in non-small cell lung cancer...
  59. Hesselink A, Heideman D, Steenbergen R, Coupé V, Overmeer R, Rijkaart D, et al. Combined promoter methylation analysis of CADM1 and MAL: an objective triage tool for high-risk human papillomavirus DNA-positive women. Clin Cancer Res. 2011;17:2459-65 pubmed publisher
    ..Here, we developed an objective assay assessing the methylation status of the promoter regions of CADM1 and MAL to triage hrHPV-positive women for CIN3(+)...
  60. You Y, Ma L, You M, Li X, Wang S, Li H, et al. TSLC1 gene silencing in cutaneous melanoma. Melanoma Res. 2010;20:179-83 pubmed publisher
    b>Tumor suppressor in lung cancer 1 (TSLC1) is a tumor suppressor gene that encodes a member of the immunoglobulin superfamily, which is involved in the progression of some types of cancer...
  61. Kuramochi M, Fukuhara H, Nobukuni T, Kanbe T, Maruyama T, Ghosh H, et al. TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Nat Genet. 2001;27:427-30 pubmed
    ..Here we report that this region contains a single confirmed gene, TSLC1, whose expression is reduced or absent in A549 and several other NSCLC, hepatocellular carcinoma (HCC) and ..