TSC1

Summary

Gene Symbol: TSC1
Description: TSC complex subunit 1
Alias: LAM, TSC, hamartin, tuberous sclerosis 1 protein
Species: human
Products:     TSC1

Top Publications

  1. Nellist M, Verhaaf B, Goedbloed M, Reuser A, van den Ouweland A, Halley D. TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex. Hum Mol Genet. 2001;10:2889-98 pubmed
    ..TSC1 and TSC2 encode two large novel proteins called hamartin and tuberin, respectively...
  2. Inoki K, Li Y, Xu T, Guan K. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 2003;17:1829-34 pubmed
    Tuberous sclerosis complex (TSC) is a genetic disease caused by mutation in either TSC1 or TSC2. The TSC1 and TSC2 gene products form a functional complex and inhibit phosphorylation of S6K and 4EBP1...
  3. Knowles M, Habuchi T, Kennedy W, Cuthbert Heavens D. Mutation spectrum of the 9q34 tuberous sclerosis gene TSC1 in transitional cell carcinoma of the bladder. Cancer Res. 2003;63:7652-6 pubmed
    ..by loss of heterozygosity (LOH) analysis, one of which encompasses one of the two loci for tuberous sclerosis, TSC1, at 9q34...
  4. Ballif B, Roux P, Gerber S, Mackeigan J, Blenis J, Gygi S. Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proc Natl Acad Sci U S A. 2005;102:667-72 pubmed
    ..in the ERK/p90 ribosomal S6 kinase-signaling targets, the tuberous sclerosis complex (TSC) tumor suppressors TSC1 and TSC2...
  5. Jansen F, Braams O, Vincken K, Algra A, Anbeek P, Jennekens Schinkel A, et al. Overlapping neurologic and cognitive phenotypes in patients with TSC1 or TSC2 mutations. Neurology. 2008;70:908-15 pubmed
    The purpose of this study was to systematically analyze the associations between different TSC1 and TSC2 mutations and the neurologic and cognitive phenotype in patients with tuberous sclerosis complex (TSC)...
  6. Han J, Sahin M. TSC1/TSC2 signaling in the CNS. FEBS Lett. 2011;585:973-80 pubmed publisher
    ..TSC is an autosomal dominant disorder that is due to inactivating mutations in TSC1 or TSC2 and characterized by benign tumors (hamartomas) involving multiple organ systems...
  7. Sun W, Zhu Y, Wang Z, Zhong Q, Gao F, Lou J, et al. Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Nat Commun. 2013;4:2135 pubmed publisher
    ..The TSC1 protein, also known as hamartin, has a critical role in controlling mTOR signalling...
  8. Nellist M, van Slegtenhorst M, Goedbloed M, van den Ouweland A, Halley D, van der Sluijs P. Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin. J Biol Chem. 1999;274:35647-52 pubmed
    ..Mutations to either the TSC1 or TSC2 gene are responsible for the disease. The TSC1 gene encodes hamartin, a 130-kDa protein without significant homology to other known mammalian proteins...
  9. Au K, Ward C, Northrup H. Tuberous sclerosis complex: disease modifiers and treatments. Curr Opin Pediatr. 2008;20:628-33 pubmed publisher
    ..The two causative genes, TSC1 and TSC2, which code for hamartin and tuberin respectively, play central roles in regulating cell survival and proliferation signaling pathways...

More Information

Publications67

  1. Dabora S, Jozwiak S, Franz D, Roberts P, Nieto A, Chung J, et al. Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am J Hum Genet. 2001;68:64-80 pubmed
    Tuberous sclerosis (TSC) is a relatively common hamartoma syndrome caused by mutations in either of two genes, TSC1 and TSC2...
  2. Neuman N, Henske E. Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis. EMBO Mol Med. 2011;3:189-200 pubmed publisher
    The protein products of the tuberous sclerosis complex (TSC) genes, TSC1 and TSC2, form a complex, which inhibits the small G-protein, Ras homolog enriched in brain (Rheb)...
  3. Liang M, Ma J, Chen L, Kozlowski P, Qin W, Li D, et al. TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity. Oncogene. 2010;29:1588-97 pubmed publisher
    Germline TSC1 or TSC2 mutations cause tuberous sclerosis complex (TSC), a hamartoma syndrome with lung involvement...
  4. Ramesh V. Aspects of tuberous sclerosis complex (TSC) protein function in the brain. Biochem Soc Trans. 2003;31:579-83 pubmed
    ..We have shown that hamartin interacts with neurofilament light chain (NF-L) and could integrate the neuronal cytoskeleton through its direct ..
  5. Jones A, Daniells C, Snell R, Tachataki M, Idziaszczyk S, Krawczak M, et al. Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis. Hum Mol Genet. 1997;6:2155-61 pubmed
    ..3 whilst the TSC1 gene, predicted to encode a novel protein termed hamartin, has recently been cloned from 9q34...
  6. Astrinidis A, Senapedis W, Henske E. Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner. Hum Mol Genet. 2006;15:287-97 pubmed
    Tuberous sclerosis complex (TSC) is a tumor suppressor gene syndrome caused by mutations in TSC1 and TSC2. Hamartin and tuberin, the products of TSC1 and TSC2, respectively, form heterodimers and inhibit the mammalian target of rapamycin...
  7. Au K, Williams A, Roach E, Batchelor L, Sparagana S, Delgado M, et al. Genotype/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States. Genet Med. 2007;9:88-100 pubmed
    ..We identified mutations in 72% (199/257) of de novo and 77% (53/68) of familial cases, with 17% of mutations in the TSC1 gene and 50% in the TSC2 gene. There were 4% unclassified variants and 29% with no mutation identified...
  8. Lee D, Kuo H, Chen C, Hsu J, Chou C, Wei Y, et al. IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell. 2007;130:440-55 pubmed
    ..The tuberous sclerosis 1 (TSC1)/TSC2 tumor suppressor complex serves as a repressor of the mTOR pathway, and disruption of TSC1/TSC2 complex ..
  9. Inoki K, Zhu T, Guan K. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003;115:577-90 pubmed
    Mutations in either the TSC1 or TSC2 tumor suppressor gene are responsible for Tuberous Sclerosis Complex...
  10. Huang J, Dibble C, Matsuzaki M, Manning B. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol. 2008;28:4104-15 pubmed publisher
    ..mTOR complex 1 (mTORC1) phosphorylates S6K1, while mTORC2 phosphorylates Akt. The TSC1-TSC2 complex is a critical negative regulator of mTORC1...
  11. Huang J, Manning B. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J. 2008;412:179-90 pubmed publisher
    ..The TSC1-TSC2 (hamartin-tuberin) complex, through its GAP (GTPase-activating protein) activity towards the small G-protein Rheb (Ras ..
  12. Hoogeveen Westerveld M, Exalto C, Maat Kievit A, van den Ouweland A, Halley D, Nellist M. Analysis of TSC1 truncations defines regions involved in TSC1 stability, aggregation and interaction. Biochim Biophys Acta. 2010;1802:774-81 pubmed publisher
    ..The disease is caused by mutations in either the TSC1 gene on chromosome 9q34, or the TSC2 gene on chromosome 16p13.3...
  13. Catania M, Mischel P, Vinters H. Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B. J Neuropathol Exp Neurol. 2001;60:711-23 pubmed
    ..TSC is associated with mutations in 2 genes, TSC1 and TSC2, which encode hamartin and tuberin, respectively. The functions of these proteins have yet to be determined...
  14. Zhang H, Nanba E, Yamamoto T, Ninomiya H, Ohno K, Mizuguchi M, et al. Mutational analysis of TSC1 and TSC2 genes in Japanese patients with tuberous sclerosis complex. J Hum Genet. 1999;44:391-6 pubmed
    We have surveyed the mutations of TSC1 and TSC2 from 38 (25 sporadic, 11 familial, and 2 unknown) Japanese patients with tuberous sclerosis complex...
  15. Niida Y, Lawrence Smith N, Banwell A, Hammer E, Lewis J, Beauchamp R, et al. Analysis of both TSC1 and TSC2 for germline mutations in 126 unrelated patients with tuberous sclerosis. Hum Mutat. 1999;14:412-22 pubmed
    ..With the cloning of two causative genes, TSC1 and TSC2 it is now possible to analyze both genes in TSC patients and identify germline mutations...
  16. Tee A, Fingar D, Manning B, Kwiatkowski D, Cantley L, Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A. 2002;99:13571-6 pubmed
    ..genetic disorder that occurs upon mutation of either the TSC1 or TSC2 genes, which encode the protein products hamartin and tuberin, respectively...
  17. Iyer G, Hanrahan A, Milowsky M, Al Ahmadie H, Scott S, Janakiraman M, et al. Genome sequencing identifies a basis for everolimus sensitivity. Science. 2012;338:221 pubmed publisher
    ..Among the somatic mutations was a loss-of-function mutation in TSC1 (tuberous sclerosis complex 1), a regulator of mTOR pathway activation...
  18. Nellist M, van den Heuvel D, Schluep D, Exalto C, Goedbloed M, Maat Kievit A, et al. Missense mutations to the TSC1 gene cause tuberous sclerosis complex. Eur J Hum Genet. 2009;17:319-28 pubmed publisher
    ..The disease is caused by mutations in either the TSC1 gene on chromosome 9q34 or the TSC2 gene on chromosome 16p13.3...
  19. Plank T, Yeung R, Henske E. Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. Cancer Res. 1998;58:4766-70 pubmed
    ..The function of hamartin, the product of TSC1, is not known...
  20. Jentarra G, Rice S, Olfers S, Saffen D, Narayanan V. Evidence for population variation in TSC1 and TSC2 gene expression. BMC Med Genet. 2011;12:29 pubmed publisher
    ..dominant neurogenetic disorder caused by mutations in one of two genes, TSC1 or TSC2, which encode the proteins hamartin and tuberin, respectively 123...
  21. Wu Q, Liu Y, Chen C, Ikenoue T, Qiao Y, Li C, et al. The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells. J Immunol. 2011;187:1106-12 pubmed publisher
    ..In this study, we report that T cell-specific deletion of Tsc1, a negative regulator of mammalian target of rapamycin, resulted in both spontaneous losses of quiescence and ..
  22. Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning B, et al. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell. 2008;29:541-51 pubmed publisher
    ..Loss of the tuberous sclerosis complex genes (TSC1 or TSC2) leads to constitutive activation of mTOR and downstream signaling elements, resulting in the development ..
  23. Hoogeveen Westerveld M, Ekong R, Povey S, Karbassi I, Batish S, den Dunnen J, et al. Functional assessment of TSC1 missense variants identified in individuals with tuberous sclerosis complex. Hum Mutat. 2012;33:476-9 pubmed publisher
    Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in the TSC1 or TSC2 genes...
  24. Chong Kopera H, Inoki K, Li Y, Zhu T, Garcia Gonzalo F, Rosa J, et al. TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J Biol Chem. 2006;281:8313-6 pubmed
    ..The TSC1 and TSC2 proteins, also called hamartin and tuberin, respectively, have been shown to regulate cell growth through inhibition of the mammalian target of ..
  25. Sancak O, Nellist M, Goedbloed M, Elfferich P, Wouters C, Maat Kievit A, et al. Mutational analysis of the TSC1 and TSC2 genes in a diagnostic setting: genotype--phenotype correlations and comparison of diagnostic DNA techniques in Tuberous Sclerosis Complex. Eur J Hum Genet. 2005;13:731-41 pubmed
    ..TSC is caused by mutations in either the TSC1 or TSC2 gene...
  26. Yamamoto Y, Jones K, Mak B, Muehlenbachs A, Yeung R. Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin. Arch Biochem Biophys. 2002;404:210-7 pubmed
    ..The function of the gene products, hamartin and tuberin, is not well understood but we have previously suggested a role in vesicular transport...
  27. Roux P, Ballif B, Anjum R, Gygi S, Blenis J. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A. 2004;101:13489-94 pubmed
    ..is a genetic disorder caused by mutations in either of the two tumor suppressor genes TSC1 or TSC2, which encode hamartin and tuberin, respectively...
  28. van Slegtenhorst M, Verhoef S, Tempelaars A, Bakker L, Wang Q, Wessels M, et al. Mutational spectrum of the TSC1 gene in a cohort of 225 tuberous sclerosis complex patients: no evidence for genotype-phenotype correlation. J Med Genet. 1999;36:285-9 pubmed
    Tuberous sclerosis complex is an inherited tumour suppressor syndrome, caused by a mutation in either the TSC1 or TSC2 gene...
  29. Kozlowski P, Roberts P, Dabora S, Franz D, Bissler J, Northrup H, et al. Identification of 54 large deletions/duplications in TSC1 and TSC2 using MLPA, and genotype-phenotype correlations. Hum Genet. 2007;121:389-400 pubmed
    Tuberous sclerosis (TSC) is an autosomal dominant disorder caused by mutations in either of two genes, TSC1 and TSC2. Point mutations and small indels account for most TSC1 and TSC2 mutations...
  30. Kwiatkowska J, Jozwiak S, Hall F, Henske E, Haines J, McNamara P, et al. Comprehensive mutational analysis of the TSC1 gene: observations on frequency of mutation, associated features, and nonpenetrance. Ann Hum Genet. 1998;62:277-85 pubmed
    We performed a comprehensive analysis for mutations in the TSC1 gene using Southern blot analysis, and SSCP and heteroduplex analysis of amplified exons in 13 families with genetic linkage to the TSC1 region, 22 small families without ..
  31. Li Y, Inoki K, Guan K. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Mol Cell Biol. 2004;24:7965-75 pubmed
    Tuberous sclerosis complex (TSC) is a genetic disease caused by a mutation in either the tsc1 or tsc2 tumor suppressor gene...
  32. Yamashita Y, Ono J, Okada S, Wataya Kaneda M, Yoshikawa K, Nishizawa M, et al. Analysis of all exons of TSC1 and TSC2 genes for germline mutations in Japanese patients with tuberous sclerosis: report of 10 mutations. Am J Med Genet. 2000;90:123-6 pubmed
    ..All mutations were expected to result in a truncated hamartin gene product...
  33. Benvenuto G, Li S, Brown S, Braverman R, Vass W, Cheadle J, et al. The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene. 2000;19:6306-16 pubmed
    We report here that overexpression of the tuberous sclerosis-1 (TSC1) gene product hamartin results in the inhibition of growth, as well as changes in cell morphology...
  34. Astrinidis A, Senapedis W, Coleman T, Henske E. Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B. J Biol Chem. 2003;278:51372-9 pubmed
    ..b>Hamartin and tuberin, the products of the TSC1 and TSC2 genes, respectively, form a complex and inhibit signaling by the ..
  35. van Slegtenhorst M, Nellist M, Nagelkerken B, Cheadle J, Snell R, van den Ouweland A, et al. Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. Hum Mol Genet. 1998;7:1053-7 pubmed
    ..The TSC1 gene was recently identified and codes for hamartin, a novel protein with no significant homology to tuberin or any other known vertebrate protein...
  36. Ma L, Chen Z, Erdjument Bromage H, Tempst P, Pandolfi P. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell. 2005;121:179-93 pubmed
    Tuberous sclerosis (TSC) is a tumor syndrome caused by mutation in TSC1 or TSC2 genes. TSC tumorigenesis is not always accompanied by loss of heterozygosity (LOH)...
  37. Goto J, Talos D, Klein P, Qin W, Chekaluk Y, Anderl S, et al. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci U S A. 2011;108:E1070-9 pubmed publisher
    ..Here, we report that mosaic induction of Tsc1 loss in neural progenitor cells in Tsc1(cc) Nestin-rtTA(+) TetOp-cre(+) embryos by doxycycline leads to multiple ..
  38. Knowles M, Hornigold N, Pitt E. Tuberous sclerosis complex (TSC) gene involvement in sporadic tumours. Biochem Soc Trans. 2003;31:597-602 pubmed
    In tuberous sclerosis patients, inactivation of the tuberous sclerosis complex tumour-suppressor genes TSC1 and TSC2 contributes to the development of a wide range of hamartomatous lesions...
  39. Hodges A, Li S, Maynard J, Parry L, Braverman R, Cheadle J, et al. Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin. Hum Mol Genet. 2001;10:2899-905 pubmed
    Critical functions of hamartin and tuberin, encoded by the TSC1 and TSC2 genes, are likely to be closely linked...
  40. Hoogeveen Westerveld M, Wentink M, van den Heuvel D, Mozaffari M, Ekong R, Povey S, et al. Functional assessment of variants in the TSC1 and TSC2 genes identified in individuals with Tuberous Sclerosis Complex. Hum Mutat. 2011;32:424-35 pubmed publisher
    ..We have used this strategy to characterize variants identified in the TSC1 and TSC2 genes in individuals with, or suspected of having, Tuberous Sclerosis Complex (TSC)...
  41. van den Ouweland A, Elfferich P, Zonnenberg B, Arts W, Kleefstra T, Nellist M, et al. Characterisation of TSC1 promoter deletions in tuberous sclerosis complex patients. Eur J Hum Genet. 2011;19:157-63 pubmed publisher
    ..Most TSC patients carry a pathogenic mutation in either TSC1 or TSC2...
  42. Orlova K, Crino P. The tuberous sclerosis complex. Ann N Y Acad Sci. 2010;1184:87-105 pubmed publisher
    Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that results from mutations in the TSC1 or TSC2 genes and is associated with hamartoma formation in multiple organ systems...
  43. Adachi H, Igawa M, Shiina H, Urakami S, Shigeno K, Hino O. Human bladder tumors with 2-hit mutations of tumor suppressor gene TSC1 and decreased expression of p27. J Urol. 2003;170:601-4 pubmed
    ..known to be the most common finding in human bladder tumors, we studied the mutation of the tumor suppressor gene TSC1 (chromosome 9q34) in bladder tumors. Since another tumor suppressor gene, TSC2 (chromosome 16p13...
  44. Pymar L, Platt F, Askham J, Morrison E, Knowles M. Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms. Hum Mol Genet. 2008;17:2006-17 pubmed publisher
    More than 50% of transitional cell carcinomas of the bladder show loss of heterozygosity of a region spanning the TSC1 locus at 9q34 and mutations of TSC1 have been identified in 14.5% of tumours...
  45. Cai S, Tee A, Short J, Bergeron J, Kim J, Shen J, et al. Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J Cell Biol. 2006;173:279-89 pubmed
    ..known how repression of mTOR signaling is relieved to activate this pathway in response to growth factors and how hamartin participates in this process...
  46. van Slegtenhorst M, de Hoogt R, Hermans C, Nellist M, Janssen B, Verhoef S, et al. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science. 1997;277:805-8 pubmed
    ..The 8.6-kilobase TSC1 transcript is widely expressed and encodes a protein of 130 kilodaltons (hamartin) that has homology to a putative yeast protein of unknown function...
  47. Chan J, Zhang H, Roberts P, Jozwiak S, Wieslawa G, Lewin Kowalik J, et al. Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. J Neuropathol Exp Neurol. 2004;63:1236-42 pubmed
    ..of biallelic mutation of TSC1 or TSC2, suggesting that SEGAs develop due to complete loss of a functional tuberin-hamartin complex...
  48. Garami A, Zwartkruis F, Nobukuni T, Joaquin M, Roccio M, Stocker H, et al. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell. 2003;11:1457-66 pubmed
    ..sclerosis (TSC) is a potentially devastating disease associated with mutations in two tumor suppressor genes, TSC1 and 2, that function as a complex to suppress signaling in the mTOR/S6K/4E-BP pathway...
  49. Goncharova E, Goncharov D, Spaits M, Noonan D, Talovskaya E, Eszterhas A, et al. Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2. Am J Respir Cell Mol Biol. 2006;34:561-72 pubmed
    The TSC1 and TSC2 proteins, which function as a TSC1/TSC2 tumor suppressor complex, are associated with lymphangioleiomyomatosis (LAM), a genetic disorder characterized by the abnormal growth of smooth muscle-like cells in the lungs...
  50. Ahamed M, Akhtar M, Alhadlaq H, Khan M, Alrokayan S. Comparative cytotoxic response of nickel ferrite nanoparticles in human liver HepG2 and breast MFC-7 cancer cells. Chemosphere. 2015;135:278-88 pubmed publisher
    ..This study warrants further investigation to explore the potential mechanisms of different cytotoxic responses of nickel ferrite NPs in different cell lines. ..
  51. Mehta M, Vazquez A, Kulkarni D, Kerrigan J, Atwal G, Metsugi S, et al. Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes. Breast Cancer Res Treat. 2011;125:861-8 pubmed publisher
    b>TSC1 acts coordinately with TSC2 in a complex to inhibit mTOR, an emerging therapeutic target and known promoter of cell growth and cell cycle progression...
  52. Reczek C, Shakya R, Miteva Y, Szabolcs M, Ludwig T, Baer R. The DNA resection protein CtIP promotes mammary tumorigenesis. Oncotarget. 2016;7:32172-83 pubmed publisher
    ..Consequently, inhibition of CtIP-mediated MMEJ may prove effective against tumor types, such as human breast cancer, that display MMEJ-dependent chromosomal rearrangements. ..
  53. Guo J, Fan K, Xie L, Xiao J, Chen K, Hui L, et al. Effect and prognostic significance of the KAI1 gene in human gastric carcinoma. Oncol Lett. 2015;10:2035-2042 pubmed
    ..It was concluded that the tumor suppressor gene KAI1 inhibits the migration and invasion of gastric carcinoma cells, possibly by suppressing the expression of uPA. Patients that expressed KAI1 may demonstrate an improved prognosis. ..
  54. Yu J, Zhang W, Gao F, Liu Y, Chen Z, Cheng L, et al. FBW7 increases chemosensitivity in hepatocellular carcinoma cells through suppression of epithelial-mesenchymal transition. Hepatobiliary Pancreat Dis Int. 2014;13:184-91 pubmed
    ..This study aimed to evaluate the role of FBW7 in chemosensitivity and epithelial-mesenchymal transition (EMT) in different hepatocellular carcinoma (HCC) cell lines and to investigate the relevant underlying mechanisms...
  55. Basova P, Pesta M, Sochor M, Stopka T. Prediction Potential of Serum miR-155 and miR-24 for Relapsing Early Breast Cancer. Int J Mol Sci. 2017;18: pubmed publisher
    ..Our approach can be translated into medical practice to estimate individual relapse risk of EBC patients. ..
  56. Wang L, Huang J, Wu C, Huang L, Cui J, Xing Z, et al. Downregulation of miR?29b targets DNMT3b to suppress cellular apoptosis and enhance proliferation in pancreatic cancer. Mol Med Rep. 2017;: pubmed publisher
    ..The results of the present study suggested that miR?29b, as a tumor suppressor, may be a novel target for the development of treatments for pancreatic cancer...
  57. Fritsche M, Knopf A. The Tumor Suppressor p53 in Mucosal Melanoma of the Head and Neck. Genes (Basel). 2017;8: pubmed publisher
    ..The current review illustrates the role of p53 and its pathway in MM. ..
  58. Paris L, Magni R, Zaidi F, Araujo R, Saini N, Harpole M, et al. Urine lipoarabinomannan glycan in HIV-negative patients with pulmonary tuberculosis correlates with disease severity. Sci Transl Med. 2017;9: pubmed publisher
    ..Past attempts failed to reliably detect the mycobacterial glycan antigen lipoarabinomannan (LAM), a marker of active TB, in HIV-negative, pulmonary TB-infected patients' urine (85% of 9.6 million patients)...