Gene Symbol: TRRAP
Description: transformation/transcription domain associated protein
Alias: PAF350/400, PAF400, STAF40, TR-AP, Tra1, transformation/transcription domain-associated protein, 350/400 kDa PCAF-associated factor, tra1 homolog
Species: human
Products:     TRRAP

Top Publications

  1. Brand M, Yamamoto K, Staub A, Tora L. Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. J Biol Chem. 1999;274:18285-9 pubmed
    ..The recently described TRRAP cofactor for oncogenic transcription factor pathways was also characterized as a TFTC subunit...
  2. Cavusoglu N, Brand M, Tora L, Van Dorsselaer A. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis. Proteomics. 2003;3:217-23 pubmed
    ..This new characterization of TFTC complex confirmed the presence of already described subunits (TRRAP, GCN5, SAP130/KIA0017, TAF(II)150, TAF(II)135, TAF(II)100, TAF(II)80, TAF(II)20, SPT3 and PAF65beta)...
  3. Martinez E, Palhan V, Tjernberg A, Lymar E, Gamper A, Kundu T, et al. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Mol Cell Biol. 2001;21:6782-95 pubmed
  4. Cai Y, Jin J, Florens L, Swanson S, Kusch T, Li B, et al. The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. J Biol Chem. 2005;280:13665-70 pubmed
    The multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase (HAT) complex performs critical functions in a variety of cellular processes including transcriptional activation, double strand DNA break repair, and apoptosis...
  5. Frontini M, Soutoglou E, Argentini M, Bole Feysot C, Jost B, Scheer E, et al. TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9. Mol Cell Biol. 2005;25:4638-49 pubmed
    ..Taken together, these data demonstrate that TAF9 and TAF9b share some of their functions, but more importantly, they have distinct roles in the transcriptional regulatory process. ..
  6. Brand M, Moggs J, Oulad Abdelghani M, Lejeune F, Dilworth F, Stevenin J, et al. UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. EMBO J. 2001;20:3187-96 pubmed
    ..Thus, our experiments reveal a molecular link between DNA damage recognition and chromatin modification. ..
  7. Soutoglou E, Demény M, Scheer E, Fienga G, Sassone Corsi P, Tora L. The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners. Mol Cell Biol. 2005;25:4092-104 pubmed
  8. Doyon Y, Selleck W, Lane W, Tan S, Cote J. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol. 2004;24:1884-96 pubmed
    ..In conclusion, the NuA4 HAT complex is highly conserved in eukaryotes, in which it plays primary roles in transcription, cellular response to DNA damage, and cell cycle control. ..
  9. Helmlinger D, Hardy S, Sasorith S, Klein F, Robert F, Weber C, et al. Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes. Hum Mol Genet. 2004;13:1257-65 pubmed
    ..We demonstrate here that ataxin-7 is the human orthologue of the yeast SAGA SGF73 subunit and is a bona fide subunit of the human TFTC-like transcriptional complexes. ..

More Information

Publications128 found, 100 shown here

  1. Palhan V, Chen S, Peng G, Tjernberg A, Gamper A, Fan Y, et al. Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc Natl Acad Sci U S A. 2005;102:8472-7 pubmed
  2. Dumevska B, Chami O, McKernan R, Goel D, Schmidt U. Derivation of Genea043 human embryonic stem cell line. Stem Cell Res. 2016;16:152-4 pubmed publisher
    ..Pluripotency of Genea043 was demonstrated with 92% of cells expressing Nanog, 95% Oct4, 61% Tra1-60 and 99% SSEA4, a PluriTest Pluripotency score of 31.74, Novelty score of 1.2 and Alkaline Phosphatase activity...
  3. Giaimo B, Ferrante F, Vallejo D, Hein K, Gutiérrez Pérez I, Nist A, et al. Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response. Nucleic Acids Res. 2018;46:8197-8215 pubmed publisher
    ..Z leads to upregulation of canonical Notch target genes and that the H2A.Z-chaperone TRRAP/p400/Tip60 complex physically associates with RBP-J at Notch-dependent enhancers...
  4. Solar P, Sytkowski A. Differentially expressed genes associated with cisplatin resistance in human ovarian adenocarcinoma cell line A2780. Cancer Lett. 2011;309:11-8 pubmed publisher numerous and diverse cellular processes, such as inhibition of apoptosis (ARHGDIB), stress response (HSPCA, TRA1), chromatin condensation (CNAP1, RanBP2), invasiveness of cells (MMP10), alteration of Ca(2+) homeostasis (ASPH, ..
  5. Sanz Garcia A, Stojkovic M, Escobedo Lucea C. Growth of Human Pluripotent Stem Cells Using Functional Human Extracellular Matrix. Methods Mol Biol. 2016;1307:39-60 pubmed publisher
    ..of medium conditioned by fibroblast cells, and that these cells maintain expression of surface proteins (SSEA4, Tra1-60, Tra1-81), alkaline phosphatase activity, and specific intracellular markers (Nanog, Oct-4, Tert, FoxD3) in ..
  6. Xin X, Jiang X, Wang L, Stover M, Zhan S, Huang J, et al. A Site-Specific Integrated Col2.3GFP Reporter Identifies Osteoblasts Within Mineralized Tissue Formed In Vivo by Human Embryonic Stem Cells. Stem Cells Transl Med. 2014;3:1125-37 pubmed publisher
    ..The karyotype was normal, and pluripotency was demonstrated by Tra1-60 immunostaining, pluripotent low density reverse transcription-polymerase chain reaction array and embryoid body ..
  7. Ebmeier C, Taatjes D. Activator-Mediator binding regulates Mediator-cofactor interactions. Proc Natl Acad Sci U S A. 2010;107:11283-8 pubmed publisher
    ..VP16-Mediator. These data define an expanded role for activators in regulating gene expression in humans and suggest that distinct, activator-induced structural shifts regulate Mediator function in gene-specific ways. ..
  8. Han Y, Luo J, Ranish J, Hahn S. Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex. EMBO J. 2014;33:2534-46 pubmed publisher
    ..The large activator-binding subunit Tra1 primarily connects to the TFIID-like core via its FAT domain...
  9. Yamaguchi H, Kawazu M, Yasuda T, Soda M, Ueno T, Kojima S, et al. Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer. Cancer Sci. 2015;106:1687-92 pubmed publisher
    ..Most of these oncogenic mutations cluster at the interface between the kinase domain and the FAT (FRAP, ATM, TRRAP) domain in the 3-D structure of mTOR...
  10. McMahon S, Wood M, Cole M. The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. Mol Cell Biol. 2000;20:556-62 pubmed
    ..We demonstrate here that the recently described c-Myc cofactor TRRAP recruits histone acetylase activity, which is catalyzed by the human GCN5 protein...
  11. Silva M, Rodrigues A, Correia C, Sousa M, Brito C, Coroadinha A, et al. Robust Expansion of Human Pluripotent Stem Cells: Integration of Bioprocess Design With Transcriptomic and Metabolomic Characterization. Stem Cells Transl Med. 2015;4:731-42 pubmed publisher
    ..Both hESC lines maintained the expression of stemness markers such as Oct-4, Nanog, SSEA-4, and TRA1-60 and the ability to spontaneously differentiate into the three germ layers...
  12. Finkbeiner M, Sawan C, Ouzounova M, Murr R, Herceg Z. HAT cofactor TRRAP mediates beta-catenin ubiquitination on the chromatin and the regulation of the canonical Wnt pathway. Cell Cycle. 2008;7:3908-14 pubmed
    ..This mechanism is mediated by the histone acetyltransferase (HAT) complex component TRRAP and Skp1, an invariable component of the Skp-Cullin-F-box (SCF) ubiquitin ligase complex...
  13. Mouradov D, Sloggett C, Jorissen R, Love C, Li S, Burgess A, et al. Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer. Cancer Res. 2014;74:3238-47 pubmed publisher
    ..ARID1A, CHD6, and SRCAP) and histone methylation or acetylation (ASH1L, EP300, EP400, MLL2, MLL3, PRDM2, and TRRAP)...
  14. Imseng S, Aylett C, Maier T. Architecture and activation of phosphatidylinositol 3-kinase related kinases. Curr Opin Struct Biol. 2018;49:177-189 pubmed publisher
    ..have now facilitated structural analysis of the major examples of PIKKs, including mTOR, DNA-PK, ATM, ATR and TRAPP/Tra1. In these PIKKs, the carboxy-terminal kinase domains and their proximal regions are structurally conserved...
  15. Berg M, Genereaux J, Karagiannis J, Brandl C. The Pseudokinase Domain of Saccharomyces cerevisiae Tra1 Is Required for Nuclear Localization and Incorporation into the SAGA and NuA4 Complexes. G3 (Bethesda). 2018;8:1943-1957 pubmed publisher
    b>Tra1 is an essential component of the SAGA/SLIK and NuA4 complexes in S. cerevisiae, recruiting these co-activator complexes to specific promoters...
  16. Bruzzone M, Grünberg S, Kubik S, Zentner G, Shore D. Distinct patterns of histone acetyltransferase and Mediator deployment at yeast protein-coding genes. Genes Dev. 2018;32:1252-1265 pubmed publisher
    ..Relative dependence on Esa1 and Tra1, a shared component of NuA4 and SAGA, distinguishes two large groups of coregulated growth-promoting genes...
  17. Sy S, Huen M, Chen J. MRG15 is a novel PALB2-interacting factor involved in homologous recombination. J Biol Chem. 2009;284:21127-31 pubmed publisher
    ..Together, our study indicated that although PALB2 is required for proficient homologous recombination, it could also govern the choice of templates used in homologous recombination repair. ..
  18. Obri A, Ouararhni K, Papin C, Diebold M, Padmanabhan K, Marek M, et al. ANP32E is a histone chaperone that removes H2A.Z from chromatin. Nature. 2014;505:648-53 pubmed publisher
    ..Z at specific chromatin control regions, in particular at enhancers and insulators. ..
  19. Dumevska B, McKernan R, Goel D, Schmidt U. Derivation of Trisomy 21 affected human embryonic stem cell line Genea053. Stem Cell Res. 2016;16:500-2 pubmed publisher
    ..The hESC line had pluripotent cell morphology and expressed pluripotent cell markers including 83% Nanog positive, 87% Oct4, 88% Tra1-60 and 98% SSEA4. The cell line was negative for Mycoplasma and visible contamination.
  20. Li H, Liu J. The novel function of HINFP as a co-activator in sterol-regulated transcription of PCSK9 in HepG2 cells. Biochem J. 2012;443:757-68 pubmed publisher form a functional complex, and NPAT may subsequently recruit the HAT (histone acetyltransferase) cofactor TRRAP (transformation/transactivation domain-associated protein) to facilitate the histone H4 acetylation of the PCSK9 ..
  21. Miki T, Wong W, Zhou E, Gonzalez A, Garcia I, Grubbs B. Biological impact of xeno-free chemically defined cryopreservation medium on amniotic epithelial cells. Stem Cell Res Ther. 2016;7:8 pubmed publisher
    ..were observed on the expression of stem cell marker genes (OCT4, SOX2, and NANOG) and a cell surface marker (TRA1-60) following cryopreservation in different chemically defined XF media, however, these were not statistically ..
  22. Dumevska B, Main H, McKernan R, Goel D, Schmidt U. Derivation of DM1 affected human embryonic stem cell line Genea067. Stem Cell Res. 2016;16:437-9 pubmed publisher
    ..The hESC line had pluripotent cell morphology, 85% of cells expressed Nanog, 97% Oct4, 73% Tra1-60 and 98% SSEA4 and gave a Pluritest Pluripotency score of 25.75, Novelty of 1.46...
  23. Gupta A, Westphal A, Yang D, Sullivan C, Eilbott J, Zaidi S, et al. Neurogenetic analysis of childhood disintegrative disorder. Mol Autism. 2017;8:19 pubmed publisher
    ..genes that were found to be most conserved at variant position and most intolerant of variation, such as TRRAP, ZNF236, and KIAA2018, play a role or may be involved in transcription...
  24. Wang Z, Plasschaert L, Aryal S, Renaud N, Yang Z, Choo Wing R, et al. TRRAP is a central regulator of human multiciliated cell formation. J Cell Biol. 2018;217:1941-1955 pubmed publisher
    ..Here, we used a pool-based short hairpin RNA screening approach and identified TRRAP, an essential component of multiple histone acetyltransferase complexes, as a central regulator of MCC formation...
  25. Smith J, Haberstroh F, White E, Livingston D, DeCaprio J, Howley P. SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter. Virology. 2014;468-470:311-21 pubmed publisher
    ..Here we show that TIP60, a component of the TIP60/TRRAP histone acetyltransferase complex, also contributes to the E2 repression function, and we extend our studies on ..
  26. Takai H, Wang R, Takai K, Yang H, de Lange T. Tel2 regulates the stability of PI3K-related protein kinases. Cell. 2007;131:1248-59 pubmed
    ..with morphological effect on genitalia 1 (SMG1), and transformation/transcription domain-associated protein (TRRAP), and curbed mTOR signaling, indicating that Tel2 affects all six mammalian PIKKs...
  27. Dumevska B, McKernan R, Goel D, Schmidt U. Derivation of NEM2 affected human embryonic stem cell line Genea080. Stem Cell Res. 2016;16:443-5 pubmed publisher
    ..The hESC line had pluripotent cell morphology, 90% of cells expressed Nanog, 95% Oct4, 54% Tra1-60 and 99% SSEA4 and gave a PluriTest Pluripotency score of 32.08, Novelty of 1.3...
  28. Dumevska B, Schaft J, McKernan R, Hu J, Schmidt U. Derivation of Huntington Disease affected Genea091 human embryonic stem cell line. Stem Cell Res. 2016;16:449-51 pubmed publisher
    ..The hESC line had pluripotent cell morphology, 92% of cells expressed Nanog, 97% Oct4, 79% Tra1-60 and 98% SSEA4 and gave a Pluritest pluripotency score of 38.36, Novelty of 1.35...
  29. Jaenicke L, von Eyss B, Carstensen A, Wolf E, Xu W, Greifenberg A, et al. Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation. Mol Cell. 2016;61:54-67 pubmed publisher
    ..In contrast, MYC turnover is essential for recruitment of TRRAP, histone acetylation, and binding of BRD4 and P-TEFb to target promoters, leading to phosphorylation of RNAPII and ..
  30. Cowling V, Chandriani S, Whitfield M, Cole M. A conserved Myc protein domain, MBIV, regulates DNA binding, apoptosis, transformation, and G2 arrest. Mol Cell Biol. 2006;26:4226-39 pubmed
    ..Thus, this conserved domain has an unexpected role in Myc DNA binding activity. These data also provide a novel separation of Myc functions linked to the modulation of DNA binding activity. ..
  31. Suzuki C, Takahashi K, Hayama S, Ishikawa N, Kato T, Ito T, et al. Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer. Mol Cancer Ther. 2007;6:542-51 pubmed
  32. Jethwa A, Słabicki M, Hüllein J, Jentzsch M, Dalal V, Rabe S, et al. TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma. Blood. 2018;: pubmed publisher
    ..We identified TRRAP, a constituent of several histone acetyltransferase (HAT) complexes, as a critical positive regulator of both ..
  33. Dumevska B, Chami O, Main H, McKernan R, Goel D, Schmidt U. Derivation of FSHD1 affected human embryonic stem cell line Genea050. Stem Cell Res. 2016;16:503-6 pubmed publisher
    ..The hESC line had pluripotent cell morphology, 92% of cells expressed Nanog, 97% Oct4, 79% Tra1-60 and 99% SSEA4, gave a Pluritest Pluripotency score of 25.45, Novelty of 1...
  34. Park J, Yang J, Wenzel A, Ramachandran A, Lee W, Daniels J, et al. Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E). Blood. 2017;130:1430-1440 pubmed publisher
    ..These novel mutations are predicted to affect chromatin (BCOR, KDM6A, SMARCB1, TRRAP), immune surveillance (CD58, RFXAP), MAPK signaling (MAP2K1, NF1), NF-?B signaling ..
  35. Dumevska B, Main H, McKernan R, Goel D, Schmidt U. Derivation of NEM2 affected human embryonic stem cell line Genea078. Stem Cell Res. 2016;16:427-9 pubmed publisher
    ..The hESC line had pluripotent cell morphology, 76% of cells expressed Nanog, 93% Oct4, 67% Tra1-60 and 97% SSEA4 and gave a Pluritest Pluripotency score of 42.18, Novelty of 1.37...
  36. Lang S, McMahon S, Cole M, Hearing P. E2F transcriptional activation requires TRRAP and GCN5 cofactors. J Biol Chem. 2001;276:32627-34 pubmed
    ..domain and show that E2F-1 and E2F-4 transactivation domains bind the acetyltransferase GCN5 and cofactor TRRAP in vivo...
  37. Moorhead G, Trinkle Mulcahy L, Nimick M, De Wever V, Campbell D, Gourlay R, et al. Displacement affinity chromatography of protein phosphatase one (PP1) complexes. BMC Biochem. 2008;9:28 pubmed publisher
    ..functions and proteins, including Ki-67, Rif-1, topoisomerase IIalpha, several nuclear helicases, NUP153 and the TRRAP complex...
  38. Vijayalingam S, Subramanian T, Zhao L, Chinnadurai G. The Cellular Protein Complex Associated with a Transforming Region of E1A Contains c-MYC. J Virol. 2016;90:1070-9 pubmed publisher the N-terminal half of E1A, which interacts with three different major cellular protein complexes, p300/CBP, TRRAP/p400, and pRb family members...
  39. Baretić D, Williams R. PIKKs--the solenoid nest where partners and kinases meet. Curr Opin Struct Biol. 2014;29:134-42 pubmed publisher
    ..for understanding all of the phosphoinositide 3-kinase (PI3K)-related kinases (PIKKs): mTOR, ATM, ATR, SMG-1, TRRAP and DNA-PK. The PIKK kinase domain is encircled by the FAT domain, a helical solenoid that is present in all PIKKs...
  40. Vdovin A, Lupatov A, Kholodenko I, Yarygin K. Comparison of the Efficiency of Viral Transduction and Episomal Transfection in Human Fibroblast Reprogramming. Bull Exp Biol Med. 2015;160:123-8 pubmed publisher
    ..Colonies of induced pluripotent cells obtained by these two methods expressed pluripotency marker Tra1-60.
  41. Dumevska B, Chami O, McKernan R, Goel D, Schmidt U. Derivation of Genea047 human embryonic stem cell line. Stem Cell Res. 2016;16:322-6 pubmed publisher
    ..Pluripotency of Genea047 was demonstrated with 88% of cells expressing Nanog, 95% Oct4, 59% Tra1-60 and 99% SSEA4, a PluriTest Pluripotency score of 30.86, Novelty score of 1.23 and tri-lineage teratoma formation...
  42. Sharov G, Voltz K, Durand A, Kolesnikova O, Papai G, Myasnikov A, et al. Structure of the transcription activator target Tra1 within the chromatin modifying complex SAGA. Nat Commun. 2017;8:1556 pubmed publisher
    ..The 430 kDa Tra1 subunit and its human homolog the transformation/transcription domain-associated protein TRRAP are members of the phosphatidyl 3-kinase-related kinase (PIKK) family...
  43. Wang X, Ahmad S, Zhang Z, Cote J, Cai G. Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex. Nat Commun. 2018;9:1147 pubmed publisher
    ..Here, we report the 4.7 Å cryo-electron microscopy (cryo-EM) structure of a NuA4/TIP60 TEEAA assembly (Tra1, Eaf1, Eaf5, actin and Arp4) and the 7...
  44. Demény M, Soutoglou E, Nagy Z, Scheer E, Janoshazi A, Richardot M, et al. Identification of a small TAF complex and its role in the assembly of TAF-containing complexes. PLoS ONE. 2007;2:e316 pubmed
  45. Dumevska B, Schaft J, McKernan R, Goel D, Schmidt U. Derivation of FSHD1 affected human embryonic stem cell line Genea096. Stem Cell Res. 2016;16:531-3 pubmed publisher
    ..The hESC line had pluripotent cell morphology, 64% of cells expressed Nanog, 93% Oct4, 58% Tra1-60 and 93% SSEA4 and a Pluritest Pluripotency score of 39.41, Novelty of 1.25...
  46. Pagano A, Araújo S, Macovei A, Leonetti P, Balestrazzi A. The Seed Repair Response during Germination: Disclosing Correlations between DNA Repair, Antioxidant Response, and Chromatin Remodeling in Medicago truncatula. Front Plant Sci. 2017;8:1972 pubmed publisher
    ..b>TRRAP is a transcriptional adaptor, so far characterized only in human cells where it is needed for the recruitment of ..
  47. Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, et al. The p400 complex is an essential E1A transformation target. Cell. 2001;106:297-307 pubmed
    ..Other components include the myc- and p/CAF-associated cofactor, TRRAP/PAF400, the DNA helicases TAP54alpha/beta, actin-like proteins, and the human homolog of the Drosophila Enhancer of ..
  48. Dumevska B, Chami O, McKernan R, Goel D, Schmidt U. Derivation of Huntington Disease affected Genea046 human embryonic stem cell line. Stem Cell Res. 2016;16:446-8 pubmed publisher
    ..The hESC line had pluripotent cell morphology, 85% of cells expressed Nanog, 92% Oct4, 75% Tra1-60 and 99% SSEA4 and demonstrated Alkaline Phosphatase activity...
  49. Dumevska B, Chami O, McKernan R, Goel D, Schmidt U. Derivation of FSHD1 affected human embryonic stem cell line Genea049. Stem Cell Res. 2016;16:469-71 pubmed publisher
    ..The hESC line had pluripotent cell morphology, 90% of cells expressed Nanog, 96% Oct4, 80% Tra1-60 and 99% SSEA4, gave a Pluritest Pluripotency score of 23.16, Novelty of 1...
  50. Liang Q, Yin Z, Zhao Y, Liang L, Feng J, Zhan Z, et al. Sequencing and comparative genomics analysis of the IncHI2 plasmids pT5282-mphA and p112298-catA and the IncHI5 plasmid pYNKP001-dfrA. Int J Antimicrob Agents. 2017;49:709-718 pubmed publisher
    ..However, the conjugal transfer regions tra1 and tra2 as well as the tellurium resistance gene cluster ter were present in all five plasmids...
  51. Wei X, Walia V, Lin J, Teer J, Prickett T, Gartner J, et al. Exome sequencing identifies GRIN2A as frequently mutated in melanoma. Nat Genet. 2011;43:442-6 pubmed publisher
    ..Most importantly, we discovered that TRRAP harbored a recurrent mutation that clustered in one position (p...
  52. Ogi H, Goto G, Ghosh A, Zencir S, Henry E, Sugimoto K. Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition. Mol Biol Cell. 2015;26:3480-8 pubmed publisher
    ..PIKKs contain a highly conserved extreme C-terminus called the FRAP-ATM-TRRAP-C-terminal (FATC) domain. In budding yeast, ATM and ATR correspond to Tel1 and Mec1, respectively...
  53. Marinowic D, Majolo F, Sebben A, da Silva V, Lopes T, Paglioli E, et al. Induced pluripotent stem cells from patients with focal cortical dysplasia and refractory epilepsy. Mol Med Rep. 2017;15:2049-2056 pubmed publisher
    ..were characterized by immunohistochemical staining for the pluripotent markers homeobox protein NANOG, SOX2, OCT4, TRA1?60 and TRA1?81...
  54. Sugimoto K. Branching the Tel2 pathway for exact fit on phosphatidylinositol 3-kinase-related kinases. Curr Genet. 2018;64:965-970 pubmed publisher
    ..PIKKs include ATM, ATR, DNA-PK, mTOR and SMG1, key regulators of cell proliferation and genome maintenance. TRRAP, which is devoid of protein kinase activity, is the sixth member of the PIKK family...
  55. Lee S, Han S, Kim M, Shim S, Shin H, Lee S, et al. Post-irradiation promotes susceptibility to reprogramming to pluripotent state in human fibroblasts. Cell Cycle. 2017;16:2119-2127 pubmed publisher the induction of reprogramming compared to that in non-irradiated cells as observed by an increased number of Tra1-81-stained colonies as well as enhanced alkaline phosphatase and Oct4 promoter activity...
  56. Assou S, Pourret E, Péquignot M, Rigau V, Kalatzis V, Aït Ahmed O, et al. Cultured Cells from the Human Oocyte Cumulus Niche Are Efficient Feeders to Propagate Pluripotent Stem Cells. Stem Cells Dev. 2015;24:2317-27 pubmed publisher
    ..for their pluripotency potential by their expression of pluripotency-associated genes such as Oct4, Nanog, and TRA1-60 and their competence to differentiate into the three germ layers in vitro (embryoid bodies) as well as in vivo (..
  57. De Cicco M, Rahim M, Dames S. Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting. Membranes (Basel). 2015;5:553-75 pubmed publisher
    ..suppressor of morphogenesis in genitalia-1 (SMG-1), and transformation/transcription domain-associated protein (TRRAP)...
  58. Zhao L, Loewenstein P, Green M. The adenoviral E1A N-terminal domain represses MYC transcription in human cancer cells by targeting both p300 and TRRAP and inhibiting MYC promoter acetylation of H3K18 and H4K16. Genes Cancer. 2016;7:98-109 pubmed publisher
    ..Deletion mutant analysis of E1A 1-80 suggests that both p300/CBP and TRRAP are involved in E1A 1-80 repression of MYC transcription...
  59. Dumevska B, Peura T, McKernan R, Goel D, Schmidt U. Derivation of Huntington disease affected Genea020 human embryonic stem cell line. Stem Cell Res. 2016;16:430-3 pubmed publisher
    ..The hESC line had pluripotent cell morphology, 89% of cells expressed Nanog, 95% Oct4, 29% Tra1-60 and 99% SSEA4, gave a Pluritest pluripotency score of 27.51, novelty of 1...
  60. Dumevska B, McKernan R, Hu J, Schmidt U. Derivation of Huntington Disease affected Genea089 human embryonic stem cell line. Stem Cell Res. 2016;16:434-6 pubmed publisher
    ..The hESC line had pluripotent cell morphology, 91% of cells expressed Nanog, 95% Oct4, 90% Tra1-60 and 100% SSEA4 and gave a PluriTest Pluripotency score of 39.28, Novelty of 1.2...
  61. Smith R, Savoian M, Weber L, Park J. Ataxia telangiectasia mutated (ATM) interacts with p400 ATPase for an efficient DNA damage response. BMC Mol Biol. 2016;17:22 pubmed
    Ataxia telangiectasia mutated (ATM) and TRRAP proteins belong to the phosphatidylinositol 3-kinase-related kinase family and are involved in DNA damage repair and chromatin remodeling...
  62. Zou Y, Deng W, Wang F, Yu X, Liu F, Yang B, et al. A novel somatic MAPK1 mutation in primary ovarian mixed germ cell tumors. Oncol Rep. 2016;35:725-30 pubmed publisher
    ..L22 (RPL22), DNA methyltransferase 3α (DNMT3A), transformation/transcription domain‑associated protein (TRRAP), isocitrate dehydrogenase (IDH)1 and IDH2 were not detected in ovarian mixed germ cell tumors, implicating these ..
  63. Asadi F, Michalski D, Karagiannis J. A Genetic Screen for Fission Yeast Gene Deletion Mutants Exhibiting Hypersensitivity to Latrunculin A. G3 (Bethesda). 2016;6:3399-3408 pubmed publisher
    ..We also identified genes with roles in histone modification (tra1, ngg1), intracellular transport (apl5, aps3), and glucose-mediated signaling (git3, git5, git11, pka1, cgs2)...
  64. McMahon S, Van Buskirk H, Dugan K, Copeland T, Cole M. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell. 1998;94:363-74 pubmed
    ..This report describes the isolation of a novel, highly conserved 434 kDa protein, designated TRRAP, which interacts specifically with the c-Myc N terminus and has homology to the ATM/PI3-kinase family...
  65. Holmlund T, Lindberg M, Grander D, Wallberg A. GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia. Leukemia. 2013;27:578-85 pubmed publisher
    ..In addition, we show that the E3 ubiquitin ligase HDM2 potentiates the degradation of E2A-PBX1. We suggest that dynamic regulation of E2A-PBX1 protein levels in vivo has a fundamental role in ALL. ..
  66. Robert F, Hardy S, Nagy Z, Baldeyron C, Murr R, Déry U, et al. The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair. Mol Cell Biol. 2006;26:402-12 pubmed
    Transactivation-transformation domain-associated protein (TRRAP) is a component of several multiprotein histone acetyltransferase (HAT) complexes implicated in transcriptional regulation...
  67. Hoffman K, Duennwald M, Karagiannis J, Genereaux J, McCarton A, Brandl C. Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response. G3 (Bethesda). 2016;6:1649-59 pubmed publisher
    ..levels of phosphatidylinositol 3-kinase-related kinase (PIKK) proteins, including mTOR, ATM/Tel1, ATR/Mec1, and TRRAP/Tra1, all of which serve as regulators of critical cell signaling pathways...
  68. Dumevska B, Bosman A, McKernan R, Goel D, Schmidt U, Peura T. Derivation of human embryonic stem cell line Genea023. Stem Cell Res. 2016;16:456-9 pubmed publisher
    ..Pluripotency of Genea023 was demonstrated with 85% of cells expressed Nanog, 98% Oct4, 55% Tra1-60 and 98% SSEA4, gave a Pluritest Pluripotency score of 42.76, Novelty of 1...
  69. Zhang H, Huang D, Wei Q, Hua T, Li F, Huang J. [Expression and its clinicopathological features of tumor rejective antigen 1 in human tissues of hepatocellular carcinoma and liver cirrhosis]. Zhonghua Gan Zang Bing Za Zhi. 2010;18:661-5 pubmed publisher
    ..The expressions of TRA1 mRNA and its protein were detected by reverse transcription polymerase chain reaction (RT-PCR) and Western blot ..
  70. Ikura T, Ogryzko V, Grigoriev M, Groisman R, Wang J, Horikoshi M, et al. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell. 2000;102:463-73 pubmed
    ..These results indicate that the histone acetylase TIP60-containing complex plays a role in DNA repair and apoptosis. ..
  71. Kaizuka T, Hara T, Oshiro N, Kikkawa U, Yonezawa K, Takehana K, et al. Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. J Biol Chem. 2010;285:20109-16 pubmed publisher
    ..interacts with and stabilizes all six members of the PIKK family of proteins (mTOR, ATM, ATR, DNA-PKcs, SMG-1, and TRRAP)...
  72. Kinyamu H, Archer T. Estrogen receptor-dependent proteasomal degradation of the glucocorticoid receptor is coupled to an increase in mdm2 protein expression. Mol Cell Biol. 2003;23:5867-81 pubmed
    ..Our study shows that cross talk between the GR and ER involves multiple signaling pathways, indicative of the mechanistic diversity within steroid receptor-regulated transcription. ..
  73. Huang S, Li X, Yusufzai T, Qiu Y, Felsenfeld G. USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier. Mol Cell Biol. 2007;27:7991-8002 pubmed
    ..These results show that USF1 plays a direct role in maintaining the barrier, supporting a model in which the insulator works as a barrier by maintaining a local environment of active chromatin. ..
  74. Zhang N, Ichikawa W, Faiola F, Lo S, Liu X, Martinez E. MYC interacts with the human STAGA coactivator complex via multivalent contacts with the GCN5 and TRRAP subunits. Biochim Biophys Acta. 2014;1839:395-405 pubmed publisher
    ..TAD-interacting coactivators have been identified, including the transcription/transformation-associated protein (TRRAP), a subunit of different histone acetyltransferase (HAT) complexes such as the human "SPT3-TAF9-GCN5 ..
  75. Liu X, Tesfai J, Evrard Y, Dent S, Martinez E. c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. J Biol Chem. 2003;278:20405-12 pubmed
    ..transformation by Myc involves its association with the transformation-transactivation domain-associated protein (TRRAP) and the human histone acetyltransferase (HAT) GCN5...
  76. Herceg Z, Wang Z. Rendez-vous at mitosis: TRRAPed in the chromatin. Cell Cycle. 2005;4:383-7 pubmed
    ..Recent genetic and cellular studies have shown that Trrap, a common component of HAT complexes, regulates the mitotic checkpoint function by modulation of mitotic ..
  77. Brès V, Yoshida T, Pickle L, Jones K. SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation. Mol Cell. 2009;36:75-87 pubmed publisher
    ..RNAi-ChIP experiments reveal that SKIP acts downstream of Tat:P-TEFb to recruit c-Myc and its partner TRRAP, a scaffold for histone acetyltransferases, to the HIV-1 promoter...
  78. Wurdak H, Zhu S, Romero A, Lorger M, Watson J, Chiang C, et al. An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation. Cell Stem Cell. 2010;6:37-47 pubmed publisher
    ..In particular, knockdown of the adaptor protein TRRAP significantly increased differentiation of cultured BTICs, sensitized the cells to apoptotic stimuli, and ..
  79. Nikiforov M, Chandriani S, Park J, Kotenko I, Matheos D, Johnsson A, et al. TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins. Mol Cell Biol. 2002;22:5054-63 pubmed
    We demonstrate that transformation-transactivation domain-associated protein (TRRAP) binding and the recruitment of histone H3 and H4 acetyltransferase activities are required for the transactivation of a silent telomerase reverse ..
  80. Giorgio G, Alfieri M, Prattichizzo C, Zullo A, Cairo S, Franco B. Functional characterization of the OFD1 protein reveals a nuclear localization and physical interaction with subunits of a chromatin remodeling complex. Mol Biol Cell. 2007;18:4397-404 pubmed
    ..On the basis of these results, we hypothesize that OFD1 may be part of a multi-protein complex and could play different biological functions in the centrosome-primary cilium organelles as well as in the nuclear compartment. ..
  81. Sustmann C, Flach H, Ebert H, Eastman Q, Grosschedl R. Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin. Mol Cell Biol. 2008;28:3526-37 pubmed publisher
    ..beta-catenin that are important for its function and association with the histone acetyltransferases CBP/p300 and TRRAP/GCN5...
  82. Lee Y, Chung T, Yoon Y, Lee M, Han S, Seong G, et al. The role of functional MR imaging in patients with ischemia in the visual cortex. AJNR Am J Neuroradiol. 2001;22:1043-9 pubmed
    ..fMR imaging of the visual cortex may be a sensitive method for the detection of vascular-compromised status in the occipital lobe. ..
  83. Ard P, Chatterjee C, Kunjibettu S, Adside L, Gralinski L, McMahon S. Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes. Mol Cell Biol. 2002;22:5650-61 pubmed
    ..Here we show that the ATM-related TRRAP protein functionally cooperates with p53 to activate mdm2 transcription...
  84. Cai Y, Jin J, Tomomori Sato C, Sato S, Sorokina I, Parmely T, et al. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. J Biol Chem. 2003;278:42733-6 pubmed
    The mammalian ATM/PI 3-kinase-related TRRAP protein was previously found to be a component of a multi-protein histone acetyltransferase (HAT) complex containing the HAT TIP60...
  85. Park J, Wood M, Cole M. BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. Mol Cell Biol. 2002;22:1307-16 pubmed
    ..We have previously reported the identification and functional characterization of four different c-Myc cofactors: TRRAP, hGCN5, TIP49, and TIP48...
  86. Sierra J, Yoshida T, Joazeiro C, Jones K. The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev. 2006;20:586-600 pubmed
    ..The beta-cat C-terminal activation domain associates with TRRAP/TIP60 and mixed-lineage-leukemia (MLL1/MLL2) SET1-type chromatin-modifying complexes in vitro, and we show that ..
  87. Zhang X, Varthi M, Sykes S, Phillips C, Warzecha C, Zhu W, et al. The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Mol Cell. 2008;29:102-11 pubmed publisher
    ..In support of a functional role within the Polycomb/cancer stem cell signature, USP22 is required for appropriate progression through the cell cycle. ..
  88. Helmlinger D, Hardy S, Abou Sleymane G, Eberlin A, Bowman A, Gansmuller A, et al. Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction. PLoS Biol. 2006;4:e67 pubmed
    ..We show here that TFTC/STAGA complexes purified from SCA7 mice have normal TRRAP, GCN5, TAF12, and SPT3 levels and that their histone or nucleosomal acetylation activities are unaffected...
  89. Ikeda T, Uno M, Honjoh S, Nishida E. The MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF-16/FOXO transcription factors. EMBO Rep. 2017;: pubmed publisher
    ..Remarkably, we also find that the human MYST family Tip60/TRRAP complex promotes oxidative stress resistance by up-regulating the expression of FOXO transcription factors in ..
  90. Feng Y, Xiang J, Liu S, Guo T, Yan G, Feng Y, et al. H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions. Nucleic Acids Res. 2017;45:10614-10633 pubmed publisher
    ..Epistasis analysis revealed that ataxia telangiectasia mutated (ATM) and the chromatin remodeling complex Tip60/TRRAP/P400 are essential for this H2AX function...
  91. Ichim G, Mola M, Finkbeiner M, Cros M, Herceg Z, Hernandez Vargas H. The histone acetyltransferase component TRRAP is targeted for destruction during the cell cycle. Oncogene. 2014;33:181-92 pubmed publisher
    ..Here, we show that the anaphase-promoting complex or cyclosome (APC/C) is involved in the mitotic turnover of TRRAP (TRansformation/tRanscription domain-Associated Protein), a common component of histone acetyltransferase (HAT) ..
  92. Lee M, Mantel C, Lee S, Moon S, Broxmeyer H. MiR-31/SDHA Axis Regulates Reprogramming Efficiency through Mitochondrial Metabolism. Stem Cell Reports. 2016;7:1-10 pubmed publisher
    ..consumption rates to that of fully reprogrammed iPSCs, but did not increase the proportion of fully reprogrammed TRA1-60(+) cells in colonies unless miR-31 was co-transduced with Yamanaka factors, which resulted in a 2...