TRPV4

Summary

Gene Symbol: TRPV4
Description: transient receptor potential cation channel subfamily V member 4
Alias: BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC, transient receptor potential cation channel subfamily V member 4, OSM9-like transient receptor potential channel 4, osm-9-like TRP channel 4, osmosensitive transient receptor potential channel 4, transient receptor potential protein 12, vanilloid receptor-like channel 2, vanilloid receptor-related osmotically activated channel
Species: human

Top Publications

  1. pmc Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4
    Arun K Shukla
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 285:30115-25. 2010
  2. pmc Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor
    W Liedtke
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    Cell 103:525-35. 2000
  3. ncbi Trp12, a novel Trp related protein from kidney
    U Wissenbach
    Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, D 66421 Homburg, Germany
    FEBS Lett 485:127-34. 2000
  4. ncbi Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2
    N S Delany
    Genome Informatics and Analysis, Virology and Vaccine Systems, Ion Channel Section, Molecular Recognition, Molecular Genetics, Glaxo Wellcome Research and Development, Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, United Kingdom
    Physiol Genomics 4:165-74. 2001
  5. ncbi Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 277:13569-77. 2002
  6. ncbi TRPV3 is a temperature-sensitive vanilloid receptor-like protein
    G D Smith
    Neurology CEDD, GlaxoSmithKline, Third Avenue, Harlow CM19 5AW, UK
    Nature 418:186-90. 2002
  7. ncbi Molecular determinants of permeation through the cation channel TRPV4
    Thomas Voets
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 277:33704-10. 2002
  8. ncbi Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 277:47044-51. 2002
  9. ncbi Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site
    Rainer Strotmann
    Institut fur Pharmakologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Thielallee 67 73, 14195 Berlin, Germany
    J Biol Chem 278:26541-9. 2003
  10. ncbi Functional TRPV4 channels are expressed in human airway smooth muscle cells
    Yanlin Jia
    Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Am J Physiol Lung Cell Mol Physiol 287:L272-8. 2004

Research Grants

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
  2. David X Zhang; Fiscal Year: 2016
  3. Sven Eric Jordt; Fiscal Year: 2016
  4. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
  5. TRPV4 Initiates Ventilator Induced Lung Injury
    James C Parker; Fiscal Year: 2010
  6. PROTEINASE-ACTIVATED RECEPTORS/PERIPHERAL NERVOUS SYSTEM
    Nigel W Bunnett; Fiscal Year: 2010
  7. David Krizaj; Fiscal Year: 2016
  8. Mechanical and Osmotic Signaling in Chondrocytes
    Farshid Guilak; Fiscal Year: 2013
  9. Alpha2-adrenoceptors modulate TRPV4 and reduce inflammation-induced visceral pain
    MARTIN R WATTS; Fiscal Year: 2013
  10. Controlling mechanical signal transduction to treat osteoarthritis
    WOLFGANG B LIEDTKE; Fiscal Year: 2013

Detail Information

Publications196 found, 100 shown here

  1. pmc Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4
    Arun K Shukla
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 285:30115-25. 2010
    ..the angiotensin receptor (AT1aR) and a member of the transient receptor potential (TRP) ion channel family, TRPV4. AT1aR and TRPV4 form a constitutive complex in the plasma membrane, and angiotensin stimulation leads to ..
  2. pmc Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor
    W Liedtke
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    Cell 103:525-35. 2000
    ..The channel also occurs in other neurosensory cells, including inner-ear hair cells, sensory neurons, and Merkel cells...
  3. ncbi Trp12, a novel Trp related protein from kidney
    U Wissenbach
    Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, D 66421 Homburg, Germany
    FEBS Lett 485:127-34. 2000
    A novel member of the transient receptor potential (Trp) family of ion channels, Trp12, was identified. The Trp12 mRNA is abundantly expressed in mouse kidney and encodes a protein of 871 amino acid residues...
  4. ncbi Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2
    N S Delany
    Genome Informatics and Analysis, Virology and Vaccine Systems, Ion Channel Section, Molecular Recognition, Molecular Genetics, Glaxo Wellcome Research and Development, Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, United Kingdom
    Physiol Genomics 4:165-74. 2001
    ..At least four vanilloid receptor-like genes exist, the newest member, VRL-2 is found in airway and kidney epithelia and in the autonomic nervous system...
  5. ncbi Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 277:13569-77. 2002
    ..human VRL-2, and murine TRP12 channels, which are highly homologous to the human VR-OAC, and the human and murine OTRPC4 channel...
  6. ncbi TRPV3 is a temperature-sensitive vanilloid receptor-like protein
    G D Smith
    Neurology CEDD, GlaxoSmithKline, Third Avenue, Harlow CM19 5AW, UK
    Nature 418:186-90. 2002
    ..Hence, not only is VRL3 a thermosensitive ion channel but it may represent an additional vanilloid receptor subunit involved in the formation of heteromeric vanilloid receptor channels...
  7. ncbi Molecular determinants of permeation through the cation channel TRPV4
    Thomas Voets
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 277:33704-10. 2002
    We have studied the molecular determinants of ion permeation through the TRPV4 channel (VRL-2, TRP12, VR-OAC, and OTRPC4)...
  8. ncbi Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 277:47044-51. 2002
    We have compared activation by heat of TRPV4 channels, heterogeneously expressed in HEK293 cells, and endogenous channels in mouse aorta endothelium (MAEC)...
  9. ncbi Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site
    Rainer Strotmann
    Institut fur Pharmakologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Thielallee 67 73, 14195 Berlin, Germany
    J Biol Chem 278:26541-9. 2003
    ..that currents through the osmo-, heat- and phorbol ester-sensitive, Ca2+-permeable nonselective cation channel TRPV4 are potentiated by intracellular Ca2+...
  10. ncbi Functional TRPV4 channels are expressed in human airway smooth muscle cells
    Yanlin Jia
    Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Am J Physiol Lung Cell Mol Physiol 287:L272-8. 2004
    ..TRPV4 (also known as VR-OAC, VRL-2, TRP12, OTRPC4), an osmotic-sensitive cation channel in the transient receptor potential (TRP) channel family, was recently ..
  11. pmc TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity
    Yaniré N Andrade
    Grup de Fisiologia Cellular i Molecular, Unitat de Senyalització Cellular, Universitat Pompeu Fabra, Barcelona 08003, Spain
    J Cell Biol 168:869-74. 2005
    ..Hamster oviductal ciliated cells express the transient receptor potential vanilloid 4 (TRPV4) channel, which is activated by increased viscous load involving a phospholipase A(2)-dependent pathway...
  12. ncbi Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking
    Maite Arniges
    Grup de Canalopaties, Unitat de Senyalització Cellular, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    J Biol Chem 281:1580-6. 2006
    The TRPV4 cation channel exhibits a topology consisting of six predicted transmembrane domains (TM) with a putative pore loop between TM5 and TM6 and intracellular N- and C-tails, the former containing at least three ankyrin domains...
  13. ncbi PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4
    Math P Cuajungco
    Department of Otolaryngology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 281:18753-62. 2006
    b>TRPV4 is a cation channel that responds to a variety of stimuli including mechanical forces, temperature, and ligand binding...
  14. pmc The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels
    Tomasz Wegierski
    Renal Division, University Hospital Freiburg, Hugstetter Strasse 55, Freiburg 79106, Germany
    EMBO J 25:5659-69. 2006
    b>TRPV4 is a widely expressed member of the transient receptor potential (TRP) family that facilitates Ca(2+) entry into nonexcitable cells...
  15. ncbi OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum
    Yan Wang
    Renal Division, University Hospital Freiburg, Hugstetter Strasse 55, Freiburg 79106, Germany
    J Biol Chem 282:36561-70. 2007
    ..expressed endoplasmic reticulum (ER)-associated protein, interacts with the cytosolic N-terminal tail of TRPV4. Using a combination of co-expression and knockdown approaches we have found that OS-9 impedes the release of ..
  16. pmc Shear stress regulates aquaporin-5 and airway epithelial barrier function
    Venkataramana K Sidhaye
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:3345-50. 2008
    ..These findings have direct relevance to the regulation of epithelial barrier function, membrane permeability, and water homeostasis in the respiratory epithelia...
  17. doi The C-terminal domain of TRPV4 is essential for plasma membrane localization
    Daniel Becker
    Kinematic Cell Research, Institute for Cell Biology and Neuroscience, JW Goethe University, Frankfurt Main, Germany
    Mol Membr Biol 25:139-51. 2008
    ..For membrane localization of the non-selective cation channel TRPV4 specific domains in the N-terminus are required, but the role of the C-terminus in the oligomerization and ..
  18. pmc IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid
    Jacqueline Fernandes
    Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain
    J Cell Biol 181:143-55. 2008
    Mechanical and osmotic sensitivity of the transient receptor potential vanilloid 4 (TRPV4) channel depends on phospholipase A(2) (PLA(2)) activation and the subsequent production of the arachidonic acid metabolites, epoxyeicosatrienoic ..
  19. pmc Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia
    Matthew J Rock
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Nat Genet 40:999-1003. 2008
    ..1-12q24.2. Among the genes in the genetic interval, we selected TRPV4, which encodes a calcium permeable cation channel of the transient receptor potential (TRP) vanilloid family, as a ..
  20. doi Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation
    Annemarieke E Loot
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Cardiovasc Res 80:445-52. 2008
    ..We therefore hypothesized that the TRPV4 channel is involved in the flow-induced vasodilatation attributed to the endothelium-derived hyperpolarizing ..
  21. doi Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli
    Tomasz Wegierski
    Renal Division, University Hospital Freiburg, Freiburg, Germany
    J Biol Chem 284:2923-33. 2009
    ..potential (TRP) family members, yet their role in the regulation of the vanilloid subfamily member 4 protein (TRPV4) remains controversial. TRPV4 is a calcium-permeable channel activated by numerous physical and chemical stimuli...
  22. pmc Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia
    Deborah Krakow
    Department of Orthopedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
    Am J Hum Genet 84:307-15. 2009
    ..autosomal-dominant brachyolmia, which can result from heterozygosity for activating mutations in the gene encoding TRPV4, a calcium-permeable ion channel...
  23. doi Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease
    Guohua Zhu
    Genetics, GlaxoSmithKline R and D, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    Hum Mol Genet 18:2053-62. 2009
    ..Upon activation by a broad range of stimuli, transient receptor potential vanilloid 4 (TRPV4) functions to control airway epithelial cell volume and epithelial and endothelial permeability; it also triggers ..
  24. pmc TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling
    Charles K Thodeti
    Vascular Biology Program, Department of Surgery, 300 Longwood Avenue, Children s Hospital Harvard Medical School, Boston, MA 02115, USA
    Circ Res 104:1123-30. 2009
    ..capillary endothelial cells adherent to flexible extracellular matrix substrates activates mechanosensitive TRPV4 (transient receptor potential vanilloid 4) ion channels that, in turn, stimulate phosphatidylinositol 3-kinase-..
  25. pmc Activation of the TRPV4 ion channel is enhanced by phosphorylation
    Hueng Chuen Fan
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom
    J Biol Chem 284:27884-91. 2009
    The TRPV4 (transient receptor potential vanilloid 4) ion channel, a member of the vanilloid subfamily of the transient receptor potential channels, is activated by membrane stretch, by non-noxious warm temperatures, and by a range of ..
  26. pmc A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia
    Wei Tian
    Department of Medicine, Divisions of Nephrology and Hypertension, and Endocrinology and Metabolism, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 106:14034-9. 2009
    ..The transient receptor potential vanilloid 4 (TRPV4) channel is postulated to comprise an element of the central tonicity-sensing mechanism in the mammalian ..
  27. pmc Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C
    Guida Landoure
    Department of Medicine, University College London, UK
    Nat Genet 42:170-4. 2010
    ..11. We sequenced all genes in this region and identified two heterozygous missense mutations in the TRPV4 gene, C805T and G806A, resulting in the amino acid substitutions R269C and R269H...
  28. pmc Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4
    Han Xiang Deng
    Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Genet 42:165-9. 2010
    ..spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC, also known as HMSN2C or Charcot-Marie-Tooth disease type 2C (CMT2C)) are phenotypically heterogeneous disorders involving ..
  29. pmc Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C
    Michaela Auer-Grumbach
    Institute of Human Genetics, Medical University of Graz, Austria
    Nat Genet 42:160-4. 2010
    ..Here we report that mutations in the TRPV4 gene cause congenital distal SMA, scapuloperoneal SMA, HMSN 2C...
  30. pmc Dominant TRPV4 mutations in nonlethal and lethal metatropic dysplasia
    Natalia Camacho
    Department of Orthopedic Surgery, University of California at Los Angeles, Los Angeles, CA 90048, USA
    Am J Med Genet A 152:1169-77. 2010
    ..Dominant mutations in the gene encoding TRPV4, a calcium permeable ion channel, were identified all 10 of a series of metatropic dysplasia cases, ranging in ..
  31. doi Spondylo-epiphyseal dysplasia, Maroteaux type (pseudo-Morquio syndrome type 2), and parastremmatic dysplasia are caused by TRPV4 mutations
    Gen Nishimura
    Department of Radiology, Tokyo Metropolitan Kiyose Children s Hospital, Kiyose, Japan
    Am J Med Genet A 152:1443-9. 2010
    ..Recent discoveries have established the existence of a family of skeletal dysplasias caused by dominant mutations in TRPV4. This family comprises, in order of increasing severity, dominant brachyolmia, spondylo-metaphyseal dysplasia ..
  32. doi Novel and recurrent TRPV4 mutations and their association with distinct phenotypes within the TRPV4 dysplasia family
    J Dai
    Laboratory for Bone and Joint Diseases, Center for Genomic Medicine, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    J Med Genet 47:704-9. 2010
    Mutations in TRPV4, a gene that encodes a Ca(2+) permeable non-selective cation channel, have recently been found in a spectrum of skeletal dysplasias that includes brachyolmia, spondylometaphyseal dysplasia, Kozlowski type (SMDK) and ..
  33. pmc Wild-type and brachyolmia-causing mutant TRPV4 channels respond directly to stretch force
    Stephen Loukin
    Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 285:27176-81. 2010
    ..b>TRPV4, a key molecular model, can be activated by hypotonicity, but the mechanism of activation is unclear...
  34. pmc TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles
    Jinju Li
    Department of Medicine, Duke University, Durham, North Carolina 27710, USA
    Environ Health Perspect 119:784-93. 2011
    ..Human respiratory epithelia function in airway mucociliary clearance and barrier function and have recently been implicated in sensory functions...
  35. pmc Increased basal activity is a key determinant in the severity of human skeletal dysplasia caused by TRPV4 mutations
    Stephen Loukin
    Laboratory of Molecular Biology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 6:e19533. 2011
    b>TRPV4 is a mechanically activated Ca(2+)-passing channel implicated in the sensing of forces, including those acting on bones. To date, 33 mutations are known to affect human bone development to different extents...
  36. pmc TRPV4 related skeletal dysplasias: a phenotypic spectrum highlighted byclinical, radiographic, and molecular studies in 21 new families
    Elena Andreucci
    Genetic Health Services Victoria and Murdoch Childrens Research Institute, Parkville, Victoria, Australia
    Orphanet J Rare Dis 6:37. 2011
    The TRPV4 gene encodes a calcium-permeable ion-channel that is widely expressed, responds to many different stimuli and participates in an extraordinarily wide range of physiologic processes...
  37. pmc Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel
    Hitoshi Inada
    Department of Molecular and Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
    Biochemistry 51:6195-206. 2012
    The TRPV4 calcium-permeable cation channel plays important physiological roles in osmosensation, mechanosensation, cell barrier formation, and bone homeostasis...
  38. ncbi OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity
    R Strotmann
    Institut fur Pharmakologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Thielallee 67 73, 14195 Berlin, Germany
    Nat Cell Biol 2:695-702. 2000
    ..Here we identify a new TRP (transient receptor potential)-like channel protein, OTRPC4, that is expressed at high levels in the kidney, liver and heart...
  39. ncbi Impaired pressure sensation in mice lacking TRPV4
    Makoto Suzuki
    Department of Pharmacology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
    J Biol Chem 278:22664-8. 2003
    ..The ion channel TRPV4 is in the TRP family and is a candidate for a mechanosensitive calcium-permeable channel...
  40. ncbi Spectrally and spatially resolved fluorescence lifetime imaging in living cells: TRPV4-microfilament interactions
    Radhan Ramadass
    Kinematic Cell Research Group, Institute for Cell Biology and Neuroscience, JW Goethe University, Max von Laue Strasse 9, D 60438 Frankfurt Main, Germany
    Arch Biochem Biophys 463:27-36. 2007
    ..method has been used to demonstrate the interactions of cation channel "transient receptor potential vanilloid 4" (TRPV4) and microfilaments...
  41. doi Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines
    José M Fernández-Fernández
    Department of Experimental and Health Sciences, Universitat Pompeu Fabra, PRBB, C Dr Aiguader 88, Barcelona, 08003, Spain
    Pflugers Arch 457:149-59. 2008
    ..We now show molecular evidence for the presence of TRPV4, a calcium permeable channel sensitive to osmotic and mechanical stress, and its functional coupling to the large ..
  42. doi Functional interaction of the cation channel transient receptor potential vanilloid 4 (TRPV4) and actin in volume regulation
    Daniel Becker
    Institute for Cell Biology and Neuroscience, Center of Excellence Frankfurt Macromolecular Complexes, JW Goethe University, Frankfurt Main, Germany
    Eur J Cell Biol 88:141-52. 2009
    ..different cell lines demonstrated a participation of the cation channel transient receptor potential vanilloid 4 (TRPV4) as well as the actin cytoskeleton in volume regulation...
  43. pmc Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies
    Magdalena Zimon
    Neurogenetics Group, VIB Department of Molecular Genetics, University of Antwerp, Universiteitsplein 1, B 2610 Antwerpen, Belgium
    Brain 133:1798-809. 2010
    ..This finding is relatively unusual in the context of hereditary neuropathies and has important implications for diagnostic testing and genetic counselling...
  44. pmc Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma
    Gerard Cantero-Recasens
    Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain
    J Biol Chem 285:27532-5. 2010
    ..to be altered under pathophysiological conditions such as chronic cough and airway hypersensitivity, whereas TRPV4 single nucleotide polymorphisms (SNP) are associated with chronic obstructive pulmonary disease...
  45. pmc CMT2C with vocal cord paresis associated with short stature and mutations in the TRPV4 gene
    D H Chen
    Department of Neurology, University of Washington Medical School, Seattle, WA, USA
    Neurology 75:1968-75. 2010
    Recently, mutations in the transient receptor potential cation channel, subfamily V, member 4 gene (TRPV4) have been reported in Charcot-Marie-Tooth Type 2C (CMT2C) with vocal cord paresis...
  46. pmc TRPV4 mutations and cytotoxic hypercalcemia in axonal Charcot-Marie-Tooth neuropathies
    C J Klein
    Department of Neurology and Division of Peripheral Nerve Diseases, Mayo Clinic Foundation, Rochester, MN 55905, USA
    Neurology 76:887-94. 2011
    To improve understanding of TRPV4-associated axonal Charcot-Marie-Tooth (CMT) neuropathy phenotypes and their debated pathologic mechanism.
  47. pmc Mutant TRPV4-mediated toxicity is linked to increased constitutive function in axonal neuropathies
    Faisal Fecto
    Division of Neuromuscular Medicine, Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 286:17281-91. 2011
    Mutations in TRPV4 have been linked to three distinct axonal neuropathies. However, the pathogenic mechanism underlying these disorders remains unclear...
  48. doi Mutations in TRPV4 cause an inherited arthropathy of hands and feet
    Shireen R Lamande
    Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Nat Genet 43:1142-6. 2011
    ..Arg271Pro and p.Phe273Leu substitutions in the intracellular ankyrin-repeat domain of the cation channel TRPV4. Functional testing of mutant TRPV4 in HEK-293 cells showed that the mutant proteins have poor cell-surface ..
  49. doi Fetal akinesia in metatropic dysplasia: The combined phenotype of chondrodysplasia and neuropathy?
    Sheila Unger
    Service of Medical Genetics, University of Lausanne, Lausanne, Switzerland
    Am J Med Genet A 155:2860-4. 2011
    Dominant mutations in the receptor calcium channel gene TRPV4 have been associated with a family of skeletal dysplasias (metatropic dysplasia, pseudo-Morquio type 2, spondylometaphyseal dysplasia, Kozlowski type, brachyolmia, and ..
  50. doi Phosphorylation on the Ser 824 residue of TRPV4 prefers to bind with F-actin than with microtubules to expand the cell surface area
    Sung Hwa Shin
    Department of Biology Education, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea
    Cell Signal 24:641-51. 2012
    Previously, we demonstrated that the transient receptor potential vanilloid 4 (TRPV4) cation channel, a member of the TRP vanilloid subfamily, is one of the serum glucocorticoid-induced protein kinase1 (SGK1) authentic substrate proteins,..
  51. doi TRPV4 axonal neuropathy spectrum disorder
    Meriel McEntagart
    Department of Medical Genetics, Medical Genetics Unit, Floor 0, Jenner Wing, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    J Clin Neurosci 19:927-33. 2012
    The TRPV4-axonal neuropathy spectrum is a group of disorders presenting as a predominantly motor axonal peripheral neuropathy, frequently in association with vocal cord paralysis, and occasionally accompanied by sensorineural hearing ..
  52. ncbi Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4)
    Makoto Suzuki
    Department of Pharmacology, Jichi Medical School 3311 1, Yakushiji, Minamikawachi, Tochigi, 329 0498, Japan
    J Biol Chem 278:51448-53. 2003
    ..Transient receptor potential vanilloid 4 (TRPV4) is a candidate in the calcium-permeable, swelling-activated mechanosensitive channel in heterogeneously expressed ..
  53. ncbi Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia
    Maite Arniges
    Laboratori de Fisiologia Molecular, Unitat de Senyalització Cellular, Universitat Pompeu Fabra, C Dr Aiguader 80, Barcelona 08003, Spain
    J Biol Chem 279:54062-8. 2004
    The vertebrate transient receptor potential cationic channel TRPV4 has been proposed as an osmo- and mechanosensor channel...
  54. ncbi Tryptase from rat skin: purification and properties
    V J Braganza
    Department of Molecular and Cellular Biochemistry, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 60153
    Biochemistry 30:4997-5007. 1991
    ..The N-terminal amino acid sequence was Ile1-Val2-Gly3-Gly4-Gln5-Glu6-Ala7-+ ++Ser8-Gly9-Asn10-Lys11-Trp12-Pro13- Trp14- Gln15-Val16-Ser17-Leu18-Arg19-Val20- --21-Asp-22Thr23-Tyr24-Typ25-, with a putative glycosylation ..
  55. pmc A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation
    N Vergnolle
    INSERM, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    Br J Pharmacol 159:1161-73. 2010
    ..Here, we investigated whether the osmosensitive channel, transient receptor potential vanilloid 4 (TRPV4), mediates inflammation to hypotonic stimuli by a neurogenic mechanism.
  56. pmc Hypotension induced by activation of the transient receptor potential vanilloid 4 channels: role of Ca2+-activated K+ channels and sensory nerves
    Feng Gao
    Division of Nanomedicine and Molecular Intervention, Department of Medicine, Michigan State University, East Lansing, Michigan, USA
    J Hypertens 28:102-10. 2010
    To examine the mechanisms involved in hypotension induced by transient receptor potential vanilloid 4 (TRPV4) activation.
  57. ncbi Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels
    Sherkheli Ma
    Department of Cell Physiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, University Street 150, Bochum 44801, Germany
    Pak J Pharm Sci 21:370-8. 2008
    ..Any of the other described thermo-sensitive TRP ion channel including TRPV1, TRPV2, TRPV3, TRPV4 and TRPA1 were not activated at a concentration (1 mM) optimally effective for TRPM8 responses; a characteristic ..
  58. pmc Changes in osmolality modulate voltage-gated sodium channels in trigeminal ganglion neurons
    Lei Chen
    Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, No 13, Hangkong Road, Wuhan 430030, PR China
    Neurosci Res 64:199-207. 2009
    ..Transient Receptor Potential Vanilloid 4 (TRPV4) receptor activator mimicked the inhibition of TTX-R current by hypotonicity and the inhibition by hypotonicity ..
  59. ncbi Topical review. Dental pain and odontoblasts: facts and hypotheses
    Henry Magloire
    University of Lyon, Lyon, France
    J Orofac Pain 24:335-49. 2010
    ..express mechano- and/or thermosensitive transient receptor potential ion channels (TRPV1, TRPV2, TRPV3, TRPV4, TRPM3, KCa, TREK-1) that are likely to sense heat and/or cold or movements of dentinal fluid within tubules...
  60. pmc Ion channel diversity, channel expression and function in the choroid plexuses
    Ian D Millar
    Faculty of Life Sciences, Core Technology Facility, University of Manchester, Manchester M13 9NT, UK
    Cerebrospinal Fluid Res 4:8. 2007
    ..choroid plexus also expresses the non-selective cation channels such as transient receptor potential channels (TRPV4 and TRPM3) and purinoceptor type 2 (P2X) receptor operated channels...
  61. pmc Intra-cochlear trafficking of aminoglycosides
    Peter S Steyger
    Oregon Hearing Research Center Oregon Health and Science University Portland, Oregon USA
    Commun Integr Biol 1:140-2. 2008
    ..recent work demonstrates that the stria vascularis exhibits high expression of the cation-selective ion channel TRPV4, and that this channel is permeable to aminoglycosides...
  62. ncbi Maxi K+ channel mediates regulatory volume decrease response in a human bronchial epithelial cell line
    José M Fernández-Fernández
    Unitat de Senyalització Cellular, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Am J Physiol Cell Physiol 283:C1705-14. 2002
    ..The presence of the recently cloned swelling-activated, Gd3+-sensitive cation channels (TRPV4, also known as OTRPC4, TRP12, or VR-OAC) was detected by RT-PCR in HBE cells...
  63. pmc Conserved residues Asp16 and Pro24 of TnaC-tRNAPro participate in tryptophan induction of Tna operon expression
    Luis R Cruz-Vera
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    J Bacteriol 190:4791-7. 2008
    ..Replacing Trp12 of TnaC with any other amino acid residue was previously shown to prevent tryptophan binding and induction of tna ..
  64. ncbi Evolution of thermoTRP ion channel homologs in vertebrates
    Shigeru Saito
    Laboratory of Bioscience, Faculty of Engineering, Iwate University, 4 3 5 Ueda, Morioka 020 8551, Japan
    Physiol Genomics 27:219-30. 2006
    ..to the transient receptor potential (TRP) superfamily and are referred to as "thermoTRPs" (TRPV1, TRPV2, TRPV3, TRPV4, TRPM2, TRPM4, TRPM5, TRPM8, and TRPA1)...
  65. ncbi Hyposmotic stimulation-induced nitric oxide production in outer hair cells of the guinea pig cochlea
    Hiroko Takeda-Nakazawa
    Hearing Research Laboratory, Department of Otolaryngology, Kansai Medical University, Fumizonocho 10 15, Moriguchi, Osaka 570 8507, Japan
    Hear Res 227:59-70. 2007
    ..Transient receptor potential vanilloid 4 (TRPV4), an osmo- and mechanosensitive channel was expressed in the OHCs by means of immunohistochemistry...
  66. ncbi Hyposmotic stimulation-induced nitric oxide production in outer hair cells of the guinea pig cochlea
    Hiroko Takeda-Nakazawa
    Hearing Research Laboratory, Department of Otolaryngology, Kansai Medical University, Fumizonocho 10 15, Moriguchi, Osaka 570 8507, Japan
    Hear Res 230:93-104. 2007
    ..Transient receptor potential vanilloid 4 (TRPV4), an osmo- and mechanosensitive channel was expressed in the OHCs by means of immunohistochemistry...
  67. doi Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture
    Ji Zhong Bai
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Auckland, New Zealand
    Neurotoxicology 31:204-14. 2010
    ..Ca(2+) permeability and gating by reactive oxygen species (TRPM2), or cell swelling, low pH and high temperature (TRPV4), they are likely to be involved in cell damage associated with various brain pathologies...
  68. doi Trpv4 induces collateral vessel growth during regeneration of the arterial circulation
    Christian Troidl
    Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    J Cell Mol Med 13:2613-21. 2009
    ..FSS), showed increased transcription of the transient receptor potential cation channel, subfamily V, member 4 (Trpv4)...
  69. pmc Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication
    Feng Gao
    Department of Medicine, Michigan State University, East Lansing, MI 48824, USA
    Hypertension 53:228-35. 2009
    To test the hypothesis that activation of the transient receptor potential vanilloid 4 (TRPV4) channel conveys a hypotensive effect that is enhanced during salt load, male Wistar rats fed a normal-sodium (0...
  70. ncbi Bisandrographolide from Andrographis paniculata activates TRPV4 channels
    Paula L Smith
    Department of Cardiology, Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 281:29897-904. 2006
    ..of extracts from 50 Chinese herbal plants using a calcium-imaging assay to find compounds active on TRPV3 and TRPV4 channels. An extract from the plant Andrographis paniculata potently activated TRPV4 channels...
  71. pmc Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA
    Shenggen Yao
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Biochemistry 47:10940-9. 2008
    ..The Trp12 and His16 side chains are close together, as in the related conotoxin mu-SmIIIA, but Asn2 is more distant...
  72. doi Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats
    Xin Li Ding
    Department of Physical Medicine and Rehabilitation, Qilu Hospital, Medical School of Shandong University, Jinan 250012, China
    Behav Brain Res 208:194-201. 2010
    The aim of the present study was to test the hypothesis that the TRPV4-NO-cGMP-PKG cascade is involved in the maintenance of thermal hyperalgesia following chronic compression of the dorsal root ganglion (DRG) (the procedure hereafter ..
  73. ncbi PLA2 and TRPV4 channels regulate endothelial calcium in cerebral arteries
    Sean P Marrelli
    Department of Anesthesiology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 292:H1390-7. 2007
    ..dilation, specifically whether PLA(2) is involved in endothelial Ca(2+) regulation through stimulation of TRPV4 channels...
  74. doi Epoxyeicosatrienoic acids function as selective, endogenous antagonists of native thromboxane receptors: identification of a novel mechanism of vasodilation
    David J Behm
    Metabolic Pathways Center of Excellence for Drug Discovery, GlaxoSmithKline, King of Prussia, Pennsylvania 19406 0939, USA
    J Pharmacol Exp Ther 328:231-9. 2009
    ..Ca(2+)-activated K(+) (BK(Ca)) and/or transient receptor potential cation channel, subfamily V, member 4 (TRPV4) channel-mediated, 14,15-EET-induced vasodilation [reversal of contractile tone established with the thromboxane ..
  75. doi Differential effects of TRPV channel block on polymodal activation of rat cutaneous nociceptors in vitro
    Michael St Pierre
    Department of Physiology and Pathophysiology, Friedrich Alexander University Erlangen Nuremberg, Universitatsstrasse 17, 91054 Erlangen, Germany
    Exp Brain Res 196:31-44. 2009
    ..other TRPV channels were cloned with polymodal properties and sensitivity to noxious heat, named TRPV2, TRPV3 and TRPV4. While TRPV3 and TRPV4 are predominantly warm sensors, TRPV2's threshold is in the noxious range (>52 degrees C)..
  76. pmc Impairment in function and expression of transient receptor potential vanilloid type 4 in Dahl salt-sensitive rats: significance and mechanism
    Feng Gao
    Department of Medicine, Michigan State University, East Lansing, Mich 48824, USA
    Hypertension 55:1018-25. 2010
    To examine the role of transient receptor potential vanilloid type 4 (TRPV4) channels in the development of salt-sensitive hypertension, male Dahl salt-sensitive (DS) and -resistant (DR) rats were fed a low-salt (LS) or high-salt (HS) ..
  77. doi Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms
    Nicolas Cenac
    Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada
    Gastroenterology 135:937-46, 946.e1-2. 2008
    The transient receptor potential vanilloid-4 (TRPV4) is an osmosensitive channel that responds to mechanical stimulation. We hypothesized that TRPV4 could be important in visceral nociception and in the development of hypersensitivity.
  78. ncbi Evidence for a functional role of endothelial transient receptor potential V4 in shear stress-induced vasodilatation
    Ralf Köhler
    Department of Internal Medicine Nephrology, Philipps University, Baldingerstrasse, 35033 Marburg, Germany
    Arterioscler Thromb Vasc Biol 26:1495-502. 2006
    ..Here, we investigated the role of the putatively mechanosensitive TRPV4 channel in the mechanisms of endothelium-dependent vasodilatation.
  79. ncbi Effects of cinnamaldehyde on PGE2 release and TRPV4 expression in mouse cerebral microvascular endothelial cells induced by interleukin-1beta
    Yue ying Ma
    Tang Center for Herbal Medicine Research, Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China
    Biol Pharm Bull 31:426-30. 2008
    ..Transient receptor potential vanilloid subtype 4 (TRPV4) is expressed in the anterior hypothalamus and may act as thermosensor...
  80. pmc The modulation of voltage-gated potassium channels by anisotonicity in trigeminal ganglion neurons
    L Chen
    Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, No 13, Hangkong Road, Wuhan, PR China
    Neuroscience 154:482-95. 2008
    ..The increase of IK by hypotonicity was mimicked by transient receptor potential vanilloid 4 (TRPV4) receptor activator 4alpha-phorbol-12,13-didecanoate (4alpha-PDD) but hypotonicity did not exhibit increase in ..
  81. pmc Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice
    Eugene Ceppa
    Departments of Surgery, University of California, San Francisco, 94143 0660, USA
    Am J Physiol Gastrointest Liver Physiol 299:G556-71. 2010
    ..We report a major role for TRPV4, which detects osmotic pressure and arachidonic acid metabolites, and TRPA1, which responds to 4-hydroxynonenal ..
  82. pmc Expression of store-operated Ca2+ entry and transient receptor potential canonical and vanilloid-related proteins in rat distal pulmonary venous smooth muscle
    Gongyong Peng
    Guangzhou Institute of Respiratory Diseases, State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, China
    Am J Physiol Lung Cell Mol Physiol 299:L621-30. 2010
    ..real-time PCR revealed mRNA expression of TRPC1 > TRPC6 > TRPC4 > TRPC2 ≈ TRPC5 > TRPC3, TRPV2 > TRPV4 > TRPV1 in distal PVSMC, and TRPC1 > TRPC6 > TRPC3 > TRPC4 ≈ TRPC5, TRPV2 ≈ TRPV4 > TRPV1 in ..
  83. pmc Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium
    Weiqun Yu
    Department of Medicine, Renal Electrolyte Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Am J Physiol Renal Physiol 300:F49-59. 2011
    ..Western blots confirmed urothelial expression of TRPC1, TRPC4, TRPV1, TRPV2, TRPV4, TRPM4, TRPM7, TRPML1, and polycystins 1 and 2 (PKD1 and PKD2) proteins...
  84. ncbi A FAAH-regulated class of N-acyl taurines that activates TRP ion channels
    Alan Saghatelian
    Department of Cell Biology, The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 45:9007-15. 2006
    ..multiple members of the transient receptor potential (TRP) family of calcium channels, including TRPV1 and TRPV4, which are both expressed in kidney...
  85. ncbi Effects of low power laser irradiation on intracellular calcium and histamine release in RBL-2H3 mast cells
    Wen Zhong Yang
    Surface Physics Laboratory National Key Laboratory, Department of Physics, Fudan University, Shanghai, China
    Photochem Photobiol 83:979-84. 2007
    ..of the extracellular buffer solution through the cation channel protein, transient receptor potential vanilloid 4 (TRPV4)...
  86. doi Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia
    Nicole Alessandri-Haber
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco, San Francisco, California 94143 0440, USA
    J Neurosci 28:1046-57. 2008
    Although the transient receptor potential vanilloid 4 (TRPV4) has been implicated in the process of osmomechanical transduction, it appears to make little contribution to the normal somatosensory detection of mechanical stimuli...
  87. pmc The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures
    Tsutomu Mochizuki
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409 3898, Japan
    J Biol Chem 284:21257-64. 2009
    ..In this study, we investigated the role of transient receptor potential vanilloid 4 (TRPV4) channels in a stretch sensing mechanism in mouse primary urothelial cell cultures...
  88. pmc A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea
    Yukako Asai
    Departments of Neuroscience and Otolaryngology, University of Virginia School of Medicine, MR4, Room 5122, Box 801392, Charlottesville, VA 22908 1392, USA
    J Assoc Res Otolaryngol 11:27-37. 2010
    ..At least four TRP genes are known to be expressed in hair cells: TRPC3, TRPV4, TRPA1, and TRPML3...
  89. pmc Functional characterization of transient receptor potential channels in mouse urothelial cells
    Wouter Everaerts
    Department of Molecular Cell Biology, Laboratory Ion Channel Research, Campus Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Physiol Renal Physiol 298:F692-701. 2010
    ..Urothelial cells from control and trpv4-/- mice were isolated, cultured (12-48 h), and used for quantitative real-time PCR, immunocytochemistry, calcium ..
  90. doi TRPV channel expression in human skin and possible role in thermally induced cell death
    Christine Radtke
    Department of Plastic, Hand and Reconstructive Surgery, Burn Center, Hannover Medical School, Germany
    J Burn Care Res 32:150-9. 2011
    ..TRPV1, TRPV2, TRPV3, and TRPV4 immunoreactivity was differentially identified on basal and suprabasal keratinocytes of healthy human skin...
  91. ncbi Glucose-evoked alterations in connexin43-mediated cell-to-cell communication in human collecting duct: a possible role in diabetic nephropathy
    Claire E Hills
    Molecular Physiology, Biomedical Research Institute, Dept of Biological Sciences, Univ of Warwick, Coventry, CV4 7AL, UK
    Am J Physiol Renal Physiol 291:F1045-51. 2006
    ..express Cx43 mRNA and protein, as well as that for the mechanosensitive transient receptor potential receptor (TRPV4)...
  92. pmc TRP channels in neurogastroenterology: opportunities for therapeutic intervention
    Werend Boesmans
    TARGID Translational Research Center for Gastrointestinal Disorders, KULeuven, Leuven, Belgium
    Br J Pharmacol 162:18-37. 2011
    ..implicated in smooth muscle cell contractility (TRPC4, TRPC6), visceral sensitivity and hypersensitivity (TRPV1, TRPV4, TRPA1), tends to be well established...
  93. doi Whole genome network analysis of ion channels and connexins in myocardial infarction
    Rui Zhou
    Institute of Clinical Pharmacology of the Second Hospital, Harbin Medical University, Harbin, People s Republic of China
    Cell Physiol Biochem 27:299-304. 2011
    ..analysis highlighted the important role of connexin 43 in MI and also identified the important biological roles of TRPV4, SCN5A, CACNA1C and TRPC6...
  94. pmc Neurophysiological characterization of mammalian osmosensitive neurones
    Charles W Bourque
    Centre for Research in Neuroscience, Montreal General Hospital and McGill University, 1650 Cedar Avenue, Montreal QC, Canada H3G 1A4
    Exp Physiol 92:499-505. 2007
    ..members of the transient receptor potential vanilloid (TRPV) family of cation channel proteins, notably TRPV1 and TRPV4. Osmotically evoked changes in the firing rate of OVLT neurones then regulate the electrical activity of ..
  95. pmc Rat Merkel cells are mechanoreceptors and osmoreceptors
    Nicholas Boulais
    University of Brest, European University of Brittany, Laboratory on Nervous Factors and Tissular Structure, EA4326, CHU, Brest, France
    PLoS ONE 4:e7759. 2009
    ..Furthermore, we found that activation of the osmoreceptor TRPV4 in FM1-43-labeled MCs provoked neurosecretory granule exocytosis...
  96. pmc Pharmacology of inflammatory pain: local alteration in receptors and mediators
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute for Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Dig Dis 27:24-30. 2009
    ..Basically, all primary afferent neurons supplying the gut can be sensitized in response to pro-inflammatory mediators, and the mechanisms whereby hypersensitivity is initiated and maintained are, thus, of prime therapeutic interest...
  97. pmc Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes
    Mimi N Phan
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 60:3028-37. 2009
    Transient receptor potential vanilloid 4 (TRPV4) is a Ca(2+)-permeable channel that can be gated by tonicity (osmolarity) and mechanical stimuli...
  98. ncbi A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators
    Nicole Alessandri-Haber
    Division of Neurosciences, Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143 0440, USA
    J Neurosci 26:3864-74. 2006
    The transient receptor potential vanilloid 4 (TRPV4) is a primary afferent transducer that plays a crucial role in neuropathic hyperalgesia for osmotic and mechanical stimuli, as well as in inflammatory mediator-induced hyperalgesia for ..
  99. ncbi Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation
    Shuji Muramatsu
    Laboratory for Drug Discovery, Research Center, Asahi Kasei Pharma Corp, 2 1 Samejima, Fuji, Shizuoka 416 8501, Japan
    J Biol Chem 282:32158-67. 2007
    ..Screening revealed that TRPV4 (transient receptor potential vanilloid 4), a cation channel molecule, significantly elevates SOX9-dependent ..
  100. pmc Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion
    Sergio A Gradilone
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 104:19138-43. 2007
    ..b>TRPV4, a Ca(2+)-permeable ion channel, has been implicated in signal transduction of osmotic stimuli...
  101. doi Inhibition of the expression and function of TRPV4 by RNA interference in dorsal root ganglion
    Ting Ting Liu
    Department of Physical Medicine and Rehabilitation, Qilu Hospital, Medical School of Shandong University, Jinan, China
    Neurol Res 32:466-71. 2010
    Transient receptor potential vanilloid 4 (TRPV4) calcium channel is an essential mediator of spinal nociceptive transmission in dorsal root ganglion (DRG), but its mechanism in pain transmission is poorly understood...

Research Grants64

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. David X Zhang; Fiscal Year: 2016
    ..The present proposal will test a central hypothesis that the transient receptor potential vanilloid 4 (TRPV4) channel serves as a common mechanism for the release of two otherwise diversely regulated relaxing factors (NO ..
  3. Sven Eric Jordt; Fiscal Year: 2016
    ..In our recent work we identified TRPV4, an ion channel expressed in the lung epithelium and vasculature, as an additional mediator of oxidant-induced ..
  4. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
    ..pain via the release of neuropeptides both in the pancreas and spinal cord, whether the newer ion channels TRPV4 and TRPA1 participate in pancreatic inflammation and pain is unknown...
  5. TRPV4 Initiates Ventilator Induced Lung Injury
    James C Parker; Fiscal Year: 2010
    ..prevented in mice by deletion of the calcium-permeable stretch-activated transient receptor potential vanilloid-4 (TRPV4) ion channel...
  6. PROTEINASE-ACTIVATED RECEPTORS/PERIPHERAL NERVOUS SYSTEM
    Nigel W Bunnett; Fiscal Year: 2010
    ..Aim 2 defines the signaling pathway by which PAR2 sensitizes TRPV4, and uses TRPV4-deficient mice to determine the role of this channel in inflammation and pain to mechanical and ..
  7. David Krizaj; Fiscal Year: 2016
    ..We found that a mechanosensitive cation channel, TRPV4, is selectively localized to retinal ganglion cells (RGCs) and in Muller glial cells...
  8. Mechanical and Osmotic Signaling in Chondrocytes
    Farshid Guilak; Fiscal Year: 2013
    ..The transient receptor potential vanilloid 4 (TRPV4) ion channel, a non-selective cation channel with a preference for Ca++, has been found to be involved in signal ..
  9. Alpha2-adrenoceptors modulate TRPV4 and reduce inflammation-induced visceral pain
    MARTIN R WATTS; Fiscal Year: 2013
    ..Transient receptor potential vanilloid 4 (TRPV4), which has been implicated in inflammatory hyperalgesia and visceral pain and is upregulated in the colons of IBD ..
  10. Controlling mechanical signal transduction to treat osteoarthritis
    WOLFGANG B LIEDTKE; Fiscal Year: 2013
    ..provided by applicant): Controlling mechanical signal transduction to treat osteoarthritis Abstract The TRPV4 calcium (Ca++) permeable ion channel has been shown to be expressed and functional in chondrocytes, the cells ..
  11. Tasuku Akiyama; Fiscal Year: 2014
    ..One of these, TRPV4, is activated by innocuous warmth...
  12. Han Xiang Deng; Fiscal Year: 2015
    ..by applicant): Through collaborative work over the past 20 years, we have discovered that mutations in the TRPV4 gene cause two allelic neuromuscular disorders, scapuloperoneal spinal muscular atrophy (SPSMA) and Charcot- Marie-..
  13. REGULATION OF SIGNALING BY CELL SURFACE PROTEOLYSIS
    Nigel W Bunnett; Fiscal Year: 2011
    ..and ion channels, including protease-activated receptor 2 (PAR2), transient receptor potential vanilloid 4 (TRPV4) and the epithelial sodium channel (ENaC)...
  14. Ca2+ Regulation in Chronic Hypoxic Pulmonary Hypertention
    JAMES SK SHAM; Fiscal Year: 2013
    ..In addition, we found that the mechanosensitive TRPV4 is highly expressed in PAs;and is the only channel, among all members of TRPM and TRPV subfamilies, being up-..
  15. COPAS BIOSORT Worm Sorter
    WOLFGANG B LIEDTKE; Fiscal Year: 2010
    ..Dr. Liedtke, the PI, will be using a mammalianized worm model to study transduction mechanisms of the mammalian TRPV4 cation channel directed to the ASH nociceptive head neuron, the cellular equivalent of the trigeminal ganglion of ..
  16. Peter M Elias; Fiscal Year: 2014
    ..aberrant xeric stress-mediated-signaling of acylCer production via the external humidity and osmotic sensors, TRPV4 and TonEBP, respectively. Together, these signaling defects account for deficiency of acylCer in AD...
  17. Andrew P Feranchak; Fiscal Year: 2016
    ..The Specific Aims are: 1) To evaluate the role of TRPV4 in the initiation of flow-induced mechanosensitive Ca2+ signaling;and to define the specific roles of shear force, ..
  18. Intracellular calcium in the treatment of polycystic kidney and liver diseases
    Sergio A Gradilone; Fiscal Year: 2010
    ..Specific Aim 2 is to evaluate the potential role of TRPV4, a calcium entry channel, as therapeutic target...
  19. CHRISTOPHER JOSEPH O'CONOR; Fiscal Year: 2015
    ..Recently, the transient receptor potential vanilloid 4 (TRPV4) ion channel, a Ca++ preferred cation channel, has emerged as a central focus in chondrocyte osmotic and ..
  20. KARIN N WESTLUND-HIGH; Fiscal Year: 2014
    ..indicate that high fat diet and alcohol induce increased expression of transient receptor potential vanilloid 4 (TRPV4) channels on pancreas cells...
  21. Endothelin mechanisms in metastic prostate cancer pain
    Gary Strichartz; Fiscal Year: 2009
    ..determine if the ET receptors in skin cells are able to modulate keratinocye TRPV1, and other TRP channels (TRPV3, TRPV4). 4...
  22. Gary R Strichartz; Fiscal Year: 2014
    ..determine if the ET receptors in skin cells are able to modulate keratinocye TRPV1, and other TRP channels (TRPV3, TRPV4). 4...
  23. Effects of shear stress on regulation of epithelial permeability
    Venkataramana K Sidhaye; Fiscal Year: 2012
    ..Our preliminary studies indicate that shear stress induces TRPV4 activation with subsequent L-type voltage gated channel activation with subsequent increases in intracellular ..
  24. MARGARET ANN VIZZARD; Fiscal Year: 2016
    ..of neurochemical mediators and the sensory transducer, transient receptor potential (TRPV) family member TRPV4, in the sensory limb of the urinary bladder reflex...
  25. The mechanism of a Chinese herbal formula on cancer pain
    Ling Xu; Fiscal Year: 2012
    ..Transient receptor potential channels, vanilloid subfamily member 1 (TRPV1), and TRPA1, and TRPV4 are also involved persistent pain...
  26. Pathologic Roles of TRP channels in Idiopathic Pulmonary Arterial Hypertension
    JAMES SK SHAM; Fiscal Year: 2013
    ..Moverover, the mechanosensitive TRPV4 channel is also up-regulated and mechanosensitive cation entry (MSCE) is enhanced in PASMCs of chronic hypoxia ..
  27. Group III mGLURs: Mechanisms of Analgesia
    Susan M Carlton; Fiscal Year: 2013
    ..on primary sensory neurons and are co-localized with TRP receptors that participate in heat (TRPV1), mechanical (TRPV4), and cold (TRPA1) transduction (aim 1)...
  28. Ching Kung; Fiscal Year: 2014
    ..We are using the rat TRP channel V4 subtype, to help fill this knowledge gap. We have now shown TRPV4's direct response to membrane stretch under Xenopus oocyte patch clamp...
  29. Reconstituting Purified Rat TRPV4 in Lipid Bilayer to Test Its Mechanosensitivity
    Ching Kung; Fiscal Year: 2010
    ..Transient-receptor-potential channel TRPV4 responds to osmotic swelling when expressed in HEK cell and in yeast...
  30. Melanocyte-Keratinocyte Cross-Talk In Relation To Barrier Function
    Peter M Elias; Fiscal Year: 2013
    ..e., tyrosinase, tyrosinase hydroxylase, and/or melanosome acidification. Finally, we will assess whether TRPV4, the epidermal sensor or external humidity, regulates pigmentary responses to decreased environmental humidity...
  31. Nicholas A Delamere; Fiscal Year: 2016
    ..Our studies in the last funding period indicate TRPV4 channels are able to trigger an increase of Na,K-ATPase activity, effectively making the Na,K-ATPase ..
  32. Importance of TRPV channels in hippocampal synaptic depression
    TRAVIS EUGENE BROWN; Fiscal Year: 2012
    ..receptor potential, vanilloid (TRPV), group 1 subfamily of channels includes four members: TRPV1, TRPV2, TRPV3 and TRPV4. TRPV channels are thermosensitive non- selective cation channels gated by a variety of endogenous ligands...
  33. RNA Aptamers Selective for TPRV Channels
    ROGER O NEIL; Fiscal Year: 2009
    ..Two isoforms of the vanilloid receptor subfamily of TRP channels, TRPV1 (the capsaicin receptor) and TRPV4 (an osmoreceptor), display polymodal gating behavior with sensitivity to numerous noxious stimuli...
  34. Aminoglycoside uptake and clearance in mammalian cells
    Takatoshi Karasawa; Fiscal Year: 2007
    ..to enter hair cells, how do aminoglycosides enter the endolymph from the vasculature? A TRPV channel, TRPV4, is expressed at the luminal membrane of marginal and endothelial cells in the stria vascularis...
  35. Molecular Studies of Osmotic Neural Sensing
    Wolfgang Liedtke; Fiscal Year: 2006
    ..The current application describes a set of experiments that will characterize the Vroac gene further. Most importantly, Vroac-/- mice will be generated by gene-targeting...
  36. Genetic determinants of water balance in the elderly
    David Cohen; Fiscal Year: 2009
    ..The cation channel TRPV4 is believed to be the long-sought central sensor of systemic hypotonicity: it is activated by relative water ..
  37. Endothelial KCa channels, Ca2+ signaling & arteriolar function in the brain
    Mark T Nelson; Fiscal Year: 2010
    ..Ca2+ signaling and the Ca2+-sensitive K+ channels, IK and SK, and TRPV4 channels in endothelial cells (ECs) activate pathways that transmit vasoregulatory signals to adjacent smooth ..
  38. Mechanisms of Vanilloid Receptor-Induced Cell Death
    Christopher Reilly; Fiscal Year: 2005
    ..Outcomes of these investigations can be utilized to predict human responses to respiratory irritants in self-defense weaponry and define the functions of vanilloid receptors lung epithelial cells. ..
  39. A Renal Epithelial Urea Sensor
    David Cohen; Fiscal Year: 2005
    ..In addition, the sufficiency of these and related signaling elements for urea signaling will be examined in models of heterologous expression. ..
  40. Expression of TRPV1 and variant TRPV1 in the kidney
    David Cohen; Fiscal Year: 2005
    ..In addition, such a reagent might have potential therapeutic utility with respect to this important pathway mediating nociception. ..
  41. TRPM4 Channels in the Control of Cerebral Artery Tone
    Scott Earley; Fiscal Year: 2005
    ..It is anticipated that these studies will generate significant new information regarding the role of mechanosensitive cation channels in the regulation of VSM membrane potential and the regulation of cerebral blood flow. ..
  42. A study of mechanosensation using microbial TRP channels
    Ching Kung; Fiscal Year: 2008
    ..Taking advantage of the facile and powerful genetic manipulations, we plan to use forward and reverse genetics to find the parts of the TrpY1 molecule that are important in mechanosensation. [unreadable] [unreadable] [unreadable]..
  43. MOLECULAR GENETICS OF PARAMECIUM
    Ching Kung; Fiscal Year: 2002
    ..Because a convenient transformation method with facilitate research of the whole community, we also plan to perfect methods of transforming paramecia en masse. ..
  44. Vanilloid Receptors in Diabetic Peripheral Neuropathy
    LOUIS PREMKUMAR; Fiscal Year: 2006
    ....
  45. T-Lymphocyte role in Lung Ischemia-Reperfusion Injury
    Mary Townsley; Fiscal Year: 2004
    ..The results of these studies will provide novel insight as to the role of lymphocytes in acute I/R-induced lung damage with the overall goal of improving success rates for clinical lung transplantation procedures. ..
  46. CA++ INHIBITION OF CAMP IN LUNG ENDOTHELIAL PERMEABILITY
    Troy Stevens; Fiscal Year: 2001
    ..It is hoped completion of these studies will improve our understanding of mechanisms which regulate endothelial barrier properties so that effective therapies can be developed for treatment of non-cardiogenic pulmonary edema. ..
  47. Determinants of Pulmonary Endothelial Cell Function Conf
    Troy Stevens; Fiscal Year: 2004
    ..At the conclusion of this meeting and as part of the published report, we will have identified areas of need for future investigation in lung vascular biology. ..
  48. 3D Woven Scaffolds for Tissue Engineering
    Farshid Guilak; Fiscal Year: 2003
    ..An improved level of biomechanical function will increase the level of success in the engineered repair of various tissues of the musculoskeletal system as well as other organ systems of the body. ..
  49. GENETIC RESCUE OF PRO-LHRH PROCESSING IN CPE FAT MICE
    William Wetsel; Fiscal Year: 2002
    ....
  50. TRANSGENIC STUDIES OF AMYOTROPHIC LATERAL SCLEROSIS
    Han Xiang Deng; Fiscal Year: 2004
    ..To achieve this goal we propose to develop additional transgenic mouse lines that over express successively smaller fragments of SOD 1 polypeptide to determine the smallest segment of SOD 1 that causes ALS. ..
  51. Agonist-evoked changes in TRPV ion channel selectivity
    Michael J Caterina; Fiscal Year: 2011
    ..Several of these channels (TRPV1, TRPV3, TRPV4) have been shown to participate in heat-evoked pain sensation in mice...
  52. INTERACTIONS OF TRPV1 AND TRPA1 AND INFLAMMATORY PAIN
    Armen N Akopian; Fiscal Year: 2010
    ..abstract_text> ..
  53. TRPV4 in Regulation of Lung Endothelial Permeability
    Mary Townsley; Fiscal Year: 2006
    ..Our preliminary data suggests a novel candidate -TRPV4-a member of the vanilloid subfamily of TRP proteins that is diversely regulated by endocannabinoids, arachidonic ..
  54. Mechanisms of resistance artery contraction
    JOSEPH ELLIOTT BRAYDEN; Fiscal Year: 2010
    ..Aim 1);TRPC3 transduces vasoconstrictor receptor responses (Aim 2);TRPV4 has a unique role in endothelial/smooth muscle communication (Aim 3)...
  55. Role of Vanilloid Receptors in Diabetic Peripheral Neuropathy
    LOUIS PREMKUMAR; Fiscal Year: 2008
    ..chemical, thermal and mechanical sensation, it is likely that TRP Vanilloid 1 (TRPV1) and TRP Vanilloid 4 (TRPV4) are involved DPN...
  56. Store Operated Calcium Entry: Lung Endothelial Permeability
    Troy Stevens; Fiscal Year: 2009
    ....
  57. Role of TRPV channels in pain and temperature sensation
    Michael Caterina; Fiscal Year: 2009
    ..Three related channels, TRPV2, TRPV3, and TRPV4, can also be activated by elevated temperatures and therefore may contribute to the detection of painful heat...
  58. 2008 Musculoskeletal Biology and Bioengineering Gordon Research Conference
    Farshid Guilak; Fiscal Year: 2008
    ..The meeting will consist of 9 separate sessions, consisting of invited speakers and selected attendees at various levels of career development. [unreadable] [unreadable] [unreadable] [unreadable]..
  59. Training in Biomolecular and Tissue Engineering
    Farshid Guilak; Fiscal Year: 2007
    ..We will also take advantage of several long-standing and successful initiatives at Duke University to enhance the recruitment of underrepresented minorities as part of this post-doctoral training program. ..
  60. Regulation of spinal NK1R expression by chronic stress
    Sylvie Bradesi; Fiscal Year: 2006
    ..This proposal is expected to provide new insights into the mechanisms by which stress affects the processing of visceral nociception. ..
  61. Mechanisms of Nociceptive Neuronal Plasticity
    ARMEN AKOPIAN; Fiscal Year: 2004
    ..abstract_text> ..
  62. Endogenous Activators of Vanilloid Receptor
    LOUIS PREMKUMAR; Fiscal Year: 2004
    ..In this way a range of normally benign stimuli will become potent activators of VRs. This research has important implications for understanding the role of VRs in hyperalgesia, chronic pain and other non-sensory functions. ..
  63. Nitric oxide in bladder neural-epithelial signaling
    Lori Birder; Fiscal Year: 2005
    ..Elucidation of mechanisms impacting on urothelial function may provide insights into the pathology of bladder dysfunction. ..
  64. REGULATION OF PULMONARY ENDOTHELIAL PERMEABILITY
    Mary Townsley; Fiscal Year: 2002
    ..Fura PE3, a ratiometric dye, will be used to measure Ca2+ transients, while patch clamp techniques will allow direct measurement of store operated Ca2+ channel activity. ..