TRPV4

Summary

Gene Symbol: TRPV4
Description: transient receptor potential cation channel subfamily V member 4
Alias: BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC, transient receptor potential cation channel subfamily V member 4, OSM9-like transient receptor potential channel 4, osm-9-like TRP channel 4, osmosensitive transient receptor potential channel 4, transient receptor potential protein 12, vanilloid receptor-like channel 2, vanilloid receptor-related osmotically activated channel
Species: human
Products:     TRPV4

Top Publications

  1. Auer Grumbach M, Olschewski A, Papić L, Kremer H, McEntagart M, Uhrig S, et al. Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C. Nat Genet. 2010;42:160-4 pubmed publisher
    ..Here we report that mutations in the TRPV4 gene cause congenital distal SMA, scapuloperoneal SMA, HMSN 2C...
  2. Fecto F, Shi Y, Huda R, Martina M, Siddique T, Deng H. Mutant TRPV4-mediated toxicity is linked to increased constitutive function in axonal neuropathies. J Biol Chem. 2011;286:17281-91 pubmed publisher
    Mutations in TRPV4 have been linked to three distinct axonal neuropathies. However, the pathogenic mechanism underlying these disorders remains unclear...
  3. Ramadass R, Becker D, Jendrach M, Bereiter Hahn J. Spectrally and spatially resolved fluorescence lifetime imaging in living cells: TRPV4-microfilament interactions. Arch Biochem Biophys. 2007;463:27-36 pubmed
    ..been used to demonstrate the interactions of cation channel "transient receptor potential vanilloid 4" (TRPV4) and microfilaments...
  4. Li J, Kanju P, Patterson M, Chew W, Cho S, Gilmour I, et al. TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. Environ Health Perspect. 2011;119:784-93 pubmed publisher
    ..possess proteolytic signaling machinery, whereby proteinase-activated receptor-2 (PAR-2) activates Ca2+-permeable TRPV4, which leads to activation of human respiratory disease-enhancing matrix metalloproteinase-1 (MMP-1), a signaling ..
  5. Zhu G, Gulsvik A, Bakke P, Ghatta S, Anderson W, Lomas D, et al. Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease. Hum Mol Genet. 2009;18:2053-62 pubmed publisher
    ..Upon activation by a broad range of stimuli, transient receptor potential vanilloid 4 (TRPV4) functions to control airway epithelial cell volume and epithelial and endothelial permeability; it also triggers ..
  6. Tian W, Fu Y, Garcia Elias A, Fernández Fernández J, Vicente R, Kramer P, et al. A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia. Proc Natl Acad Sci U S A. 2009;106:14034-9 pubmed publisher
    ..The transient receptor potential vanilloid 4 (TRPV4) channel is postulated to comprise an element of the central tonicity-sensing mechanism in the mammalian ..
  7. Loukin S, Su Z, Kung C. Increased basal activity is a key determinant in the severity of human skeletal dysplasia caused by TRPV4 mutations. PLoS ONE. 2011;6:e19533 pubmed publisher
    b>TRPV4 is a mechanically activated Ca(2+)-passing channel implicated in the sensing of forces, including those acting on bones. To date, 33 mutations are known to affect human bone development to different extents...
  8. Fernandes J, Lorenzo I, Andrade Y, Garcia Elias A, Serra S, Fernández Fernández J, et al. IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid. J Cell Biol. 2008;181:143-55 pubmed publisher
    Mechanical and osmotic sensitivity of the transient receptor potential vanilloid 4 (TRPV4) channel depends on phospholipase A(2) (PLA(2)) activation and the subsequent production of the arachidonic acid metabolites, epoxyeicosatrienoic ..
  9. Arniges M, Fernández Fernández J, Albrecht N, Schaefer M, Valverde M. Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem. 2006;281:1580-6 pubmed
    The TRPV4 cation channel exhibits a topology consisting of six predicted transmembrane domains (TM) with a putative pore loop between TM5 and TM6 and intracellular N- and C-tails, the former containing at least three ankyrin domains...

More Information

Publications73

  1. Fan H, Zhang X, McNaughton P. Activation of the TRPV4 ion channel is enhanced by phosphorylation. J Biol Chem. 2009;284:27884-91 pubmed publisher
    The TRPV4 (transient receptor potential vanilloid 4) ion channel, a member of the vanilloid subfamily of the transient receptor potential channels, is activated by membrane stretch, by non-noxious warm temperatures, and by a range of ..
  2. Lamande S, Yuan Y, Gresshoff I, Rowley L, Belluoccio D, Kaluarachchi K, et al. Mutations in TRPV4 cause an inherited arthropathy of hands and feet. Nat Genet. 2011;43:1142-6 pubmed publisher
    ..Arg271Pro and p.Phe273Leu substitutions in the intracellular ankyrin-repeat domain of the cation channel TRPV4. Functional testing of mutant TRPV4 in HEK-293 cells showed that the mutant proteins have poor cell-surface ..
  3. Wegierski T, Lewandrowski U, Muller B, Sickmann A, Walz G. Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli. J Biol Chem. 2009;284:2923-33 pubmed publisher
    ..potential (TRP) family members, yet their role in the regulation of the vanilloid subfamily member 4 protein (TRPV4) remains controversial. TRPV4 is a calcium-permeable channel activated by numerous physical and chemical stimuli...
  4. Smith G, Gunthorpe M, Kelsell R, Hayes P, Reilly P, Facer P, et al. TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature. 2002;418:186-90 pubmed
    ..Hence, not only is VRL3 a thermosensitive ion channel but it may represent an additional vanilloid receptor subunit involved in the formation of heteromeric vanilloid receptor channels. ..
  5. Watanabe H, Davis J, Smart D, Jerman J, Smith G, Hayes P, et al. Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem. 2002;277:13569-77 pubmed
    ..human VRL-2, and murine TRP12 channels, which are highly homologous to the human VR-OAC, and the human and murine OTRPC4 channel...
  6. Loukin S, Zhou X, Su Z, Saimi Y, Kung C. Wild-type and brachyolmia-causing mutant TRPV4 channels respond directly to stretch force. J Biol Chem. 2010;285:27176-81 pubmed publisher
    ..b>TRPV4, a key molecular model, can be activated by hypotonicity, but the mechanism of activation is unclear...
  7. Becker D, Bereiter Hahn J, Jendrach M. Functional interaction of the cation channel transient receptor potential vanilloid 4 (TRPV4) and actin in volume regulation. Eur J Cell Biol. 2009;88:141-52 pubmed publisher
    ..different cell lines demonstrated a participation of the cation channel transient receptor potential vanilloid 4 (TRPV4) as well as the actin cytoskeleton in volume regulation...
  8. Zimon M, Baets J, Auer Grumbach M, Berciano J, Garcia A, Lopez Laso E, et al. Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies. Brain. 2010;133:1798-809 pubmed publisher
    ..This finding is relatively unusual in the context of hereditary neuropathies and has important implications for diagnostic testing and genetic counselling. ..
  9. Watanabe H, Vriens J, Suh S, Benham C, Droogmans G, Nilius B. Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem. 2002;277:47044-51 pubmed
    We have compared activation by heat of TRPV4 channels, heterogeneously expressed in HEK293 cells, and endogenous channels in mouse aorta endothelium (MAEC)...
  10. Chen D, Sul Y, Weiss M, Hillel A, Lipe H, Wolff J, et al. CMT2C with vocal cord paresis associated with short stature and mutations in the TRPV4 gene. Neurology. 2010;75:1968-75 pubmed publisher
    Recently, mutations in the transient receptor potential cation channel, subfamily V, member 4 gene (TRPV4) have been reported in Charcot-Marie-Tooth Type 2C (CMT2C) with vocal cord paresis...
  11. Wissenbach U, Bödding M, Freichel M, Flockerzi V. Trp12, a novel Trp related protein from kidney. FEBS Lett. 2000;485:127-34 pubmed
    A novel member of the transient receptor potential (Trp) family of ion channels, Trp12, was identified. The Trp12 mRNA is abundantly expressed in mouse kidney and encodes a protein of 871 amino acid residues...
  12. Krakow D, Vriens J, Camacho N, Luong P, Deixler H, Funari T, et al. Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia. Am J Hum Genet. 2009;84:307-15 pubmed publisher
    ..autosomal-dominant brachyolmia, which can result from heterozygosity for activating mutations in the gene encoding TRPV4, a calcium-permeable ion channel...
  13. Deng H, Klein C, Yan J, Shi Y, Wu Y, Fecto F, et al. Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4. Nat Genet. 2010;42:165-9 pubmed publisher
    ..spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC, also known as HMSN2C or Charcot-Marie-Tooth disease type 2C (CMT2C)) are phenotypically heterogeneous disorders involving ..
  14. Cuajungco M, Grimm C, Oshima K, D hoedt D, Nilius B, Mensenkamp A, et al. PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. J Biol Chem. 2006;281:18753-62 pubmed
    b>TRPV4 is a cation channel that responds to a variety of stimuli including mechanical forces, temperature, and ligand binding...
  15. Klein C, Shi Y, Fecto F, Donaghy M, Nicholson G, McEntagart M, et al. TRPV4 mutations and cytotoxic hypercalcemia in axonal Charcot-Marie-Tooth neuropathies. Neurology. 2011;76:887-94 pubmed publisher
    ..A total of 17 CMT2C phenotypic families with vocal cord and diaphragmatic involvement and 36 clinically undifferentiated CMT2 subjects ..
  16. Unger S, Lausch E, Stanzial F, Gillessen Kaesbach G, Stefanova I, Di Stefano C, et al. Fetal akinesia in metatropic dysplasia: The combined phenotype of chondrodysplasia and neuropathy?. Am J Med Genet A. 2011;155A:2860-4 pubmed publisher
    Dominant mutations in the receptor calcium channel gene TRPV4 have been associated with a family of skeletal dysplasias (metatropic dysplasia, pseudo-Morquio type 2, spondylometaphyseal dysplasia, Kozlowski type, brachyolmia, and ..
  17. Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant T. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol. 2000;2:695-702 pubmed
    ..Here we identify a new TRP (transient receptor potential)-like channel protein, OTRPC4, that is expressed at high levels in the kidney, liver and heart...
  18. Landoure G, Zdebik A, Martinez T, Burnett B, Stanescu H, Inada H, et al. Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C. Nat Genet. 2010;42:170-4 pubmed publisher
    Charcot-Marie-Tooth disease type 2C (CMT2C) is an autosomal dominant neuropathy characterized by limb, diaphragm and laryngeal muscle weakness. Two unrelated families with CMT2C showed significant linkage to chromosome 12q24.11...
  19. Andreucci E, Aftimos S, Alcausin M, Haan E, Hunter W, Kannu P, et al. TRPV4 related skeletal dysplasias: a phenotypic spectrum highlighted byclinical, radiographic, and molecular studies in 21 new families. Orphanet J Rare Dis. 2011;6:37 pubmed publisher
    The TRPV4 gene encodes a calcium-permeable ion-channel that is widely expressed, responds to many different stimuli and participates in an extraordinarily wide range of physiologic processes...
  20. Shin S, Lee E, Hyun S, Chun J, Kim Y, Kang S. Phosphorylation on the Ser 824 residue of TRPV4 prefers to bind with F-actin than with microtubules to expand the cell surface area. Cell Signal. 2012;24:641-51 pubmed publisher
    Previously, we demonstrated that the transient receptor potential vanilloid 4 (TRPV4) cation channel, a member of the TRP vanilloid subfamily, is one of the serum glucocorticoid-induced protein kinase1 (SGK1) authentic substrate proteins,..
  21. Liedtke W, Choe Y, Martí Renom M, Bell A, Denis C, Sali A, et al. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell. 2000;103:525-35 pubmed
    ..The channel also occurs in other neurosensory cells, including inner-ear hair cells, sensory neurons, and Merkel cells. ..
  22. Rock M, Prenen J, Funari V, Funari T, Merriman B, Nelson S, et al. Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nat Genet. 2008;40:999-1003 pubmed publisher
    ..1-12q24.2. Among the genes in the genetic interval, we selected TRPV4, which encodes a calcium permeable cation channel of the transient receptor potential (TRP) vanilloid family, as a ..
  23. Suzuki M, Hirao A, Mizuno A. Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J Biol Chem. 2003;278:51448-53 pubmed
    ..Transient receptor potential vanilloid 4 (TRPV4) is a candidate in the calcium-permeable, swelling-activated mechanosensitive channel in heterogeneously expressed ..
  24. Loot A, Popp R, Fisslthaler B, Vriens J, Nilius B, Fleming I. Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation. Cardiovasc Res. 2008;80:445-52 pubmed publisher
    ..We therefore hypothesized that the TRPV4 channel is involved in the flow-induced vasodilatation attributed to the endothelium-derived hyperpolarizing ..
  25. Fernández Fernández J, Andrade Y, Arniges M, Fernandes J, Plata C, Rubio Moscardo F, et al. Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines. Pflugers Arch. 2008;457:149-59 pubmed publisher
    ..We now show molecular evidence for the presence of TRPV4, a calcium permeable channel sensitive to osmotic and mechanical stress, and its functional coupling to the large ..
  26. Voets T, Prenen J, Vriens J, Watanabe H, Janssens A, Wissenbach U, et al. Molecular determinants of permeation through the cation channel TRPV4. J Biol Chem. 2002;277:33704-10 pubmed
    We have studied the molecular determinants of ion permeation through the TRPV4 channel (VRL-2, TRP12, VR-OAC, and OTRPC4)...
  27. Jia Y, Wang X, Varty L, Rizzo C, Yang R, Correll C, et al. Functional TRPV4 channels are expressed in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2004;287:L272-8 pubmed
    ..TRPV4 (also known as VR-OAC, VRL-2, TRP12, OTRPC4), an osmotic-sensitive cation channel in the transient receptor potential (TRP) channel family, was recently ..
  28. Becker D, Müller M, Leuner K, Jendrach M. The C-terminal domain of TRPV4 is essential for plasma membrane localization. Mol Membr Biol. 2008;25:139-51 pubmed publisher
    ..For membrane localization of the non-selective cation channel TRPV4 specific domains in the N-terminus are required, but the role of the C-terminus in the oligomerization and ..
  29. Wang Y, Fu X, Gaiser S, Köttgen M, Kramer Zucker A, Walz G, et al. OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum. J Biol Chem. 2007;282:36561-70 pubmed
    ..expressed endoplasmic reticulum (ER)-associated protein, interacts with the cytosolic N-terminal tail of TRPV4. Using a combination of co-expression and knockdown approaches we have found that OS-9 impedes the release of ..
  30. Delany N, Hurle M, Facer P, Alnadaf T, Plumpton C, Kinghorn I, et al. Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2. Physiol Genomics. 2001;4:165-74 pubmed
    ..At least four vanilloid receptor-like genes exist, the newest member, VRL-2 is found in airway and kidney epithelia and in the autonomic nervous system...
  31. Nishimura G, Dai J, Lausch E, Unger S, Megarbane A, Kitoh H, et al. Spondylo-epiphyseal dysplasia, Maroteaux type (pseudo-Morquio syndrome type 2), and parastremmatic dysplasia are caused by TRPV4 mutations. Am J Med Genet A. 2010;152A:1443-9 pubmed publisher
    ..Recent discoveries have established the existence of a family of skeletal dysplasias caused by dominant mutations in TRPV4. This family comprises, in order of increasing severity, dominant brachyolmia, spondylo-metaphyseal dysplasia ..
  32. Dai J, Kim O, Cho T, Schmidt Rimpler M, Tonoki H, Takikawa K, et al. Novel and recurrent TRPV4 mutations and their association with distinct phenotypes within the TRPV4 dysplasia family. J Med Genet. 2010;47:704-9 pubmed publisher
    Mutations in TRPV4, a gene that encodes a Ca(2+) permeable non-selective cation channel, have recently been found in a spectrum of skeletal dysplasias that includes brachyolmia, spondylometaphyseal dysplasia, Kozlowski type (SMDK) and ..
  33. Suzuki M, Mizuno A, Kodaira K, Imai M. Impaired pressure sensation in mice lacking TRPV4. J Biol Chem. 2003;278:22664-8 pubmed
    ..The ion channel TRPV4 is in the TRP family and is a candidate for a mechanosensitive calcium-permeable channel...
  34. Andrade Y, Fernandes J, Vazquez E, Fernández Fernández J, Arniges M, Sánchez T, et al. TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J Cell Biol. 2005;168:869-74 pubmed
    ..Hamster oviductal ciliated cells express the transient receptor potential vanilloid 4 (TRPV4) channel, which is activated by increased viscous load involving a phospholipase A(2)-dependent pathway...
  35. Thodeti C, Matthews B, Ravi A, Mammoto A, Ghosh K, Bracha A, et al. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res. 2009;104:1123-30 pubmed publisher
    ..capillary endothelial cells adherent to flexible extracellular matrix substrates activates mechanosensitive TRPV4 (transient receptor potential vanilloid 4) ion channels that, in turn, stimulate phosphatidylinositol 3-kinase-..
  36. Inada H, Procko E, Sotomayor M, Gaudet R. Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry. 2012;51:6195-206 pubmed
    The TRPV4 calcium-permeable cation channel plays important physiological roles in osmosensation, mechanosensation, cell barrier formation, and bone homeostasis...
  37. Strotmann R, Schultz G, Plant T. Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site. J Biol Chem. 2003;278:26541-9 pubmed
    ..that currents through the osmo-, heat- and phorbol ester-sensitive, Ca2+-permeable nonselective cation channel TRPV4 are potentiated by intracellular Ca2+...
  38. Sidhaye V, Schweitzer K, Caterina M, Shimoda L, King L. Shear stress regulates aquaporin-5 and airway epithelial barrier function. Proc Natl Acad Sci U S A. 2008;105:3345-50 pubmed publisher
    ..These findings have direct relevance to the regulation of epithelial barrier function, membrane permeability, and water homeostasis in the respiratory epithelia. ..
  39. Wegierski T, Hill K, Schaefer M, Walz G. The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels. EMBO J. 2006;25:5659-69 pubmed
    b>TRPV4 is a widely expressed member of the transient receptor potential (TRP) family that facilitates Ca(2+) entry into nonexcitable cells...
  40. Arniges M, Vazquez E, Fernández Fernández J, Valverde M. Swelling-activated Ca2+ entry via TRPV4 channel is defective in cystic fibrosis airway epithelia. J Biol Chem. 2004;279:54062-8 pubmed
    The vertebrate transient receptor potential cationic channel TRPV4 has been proposed as an osmo- and mechanosensor channel...
  41. Camacho N, Krakow D, Johnykutty S, Katzman P, Pepkowitz S, Vriens J, et al. Dominant TRPV4 mutations in nonlethal and lethal metatropic dysplasia. Am J Med Genet A. 2010;152A:1169-77 pubmed publisher
    ..Dominant mutations in the gene encoding TRPV4, a calcium permeable ion channel, were identified all 10 of a series of metatropic dysplasia cases, ranging in ..
  42. McEntagart M. TRPV4 axonal neuropathy spectrum disorder. J Clin Neurosci. 2012;19:927-33 pubmed publisher
    The TRPV4-axonal neuropathy spectrum is a group of disorders presenting as a predominantly motor axonal peripheral neuropathy, frequently in association with vocal cord paralysis, and occasionally accompanied by sensorineural hearing ..
  43. Nishida T, Kubota S, Aoyama E, Yamanaka N, Lyons K, Takigawa M. Low-intensity pulsed ultrasound (LIPUS) treatment of cultured chondrocytes stimulates production of CCN family protein 2 (CCN2), a protein involved in the regeneration of articular cartilage: mechanism underlying this stimulation. Osteoarthritis Cartilage. 2017;25:759-769 pubmed publisher
    ..MAPK) and extracellular signal-regulated kinase (ERK)1/2 were increased by LIPUS treatment, and the stability of TRPV4 and BKca channel mRNAs was decreased by siRNA against CCN2...
  44. Dietrich A, Steinritz D, Gudermann T. Transient receptor potential (TRP) channels as molecular targets in lung toxicology and associated diseases. Cell Calcium. 2017;67:123-137 pubmed publisher
    ..In this review we will summarize recent evidence for an involvement of TRP channels (TRPA1, TRPC4, TRPC6, TRPV1, TRPV4, TRPM2 and TRPM8) expressed in the lung in pathways of toxin sensing and as mediators of lung inflammation and ..
  45. Thoppil R, Cappelli H, Adapala R, Kanugula A, Paruchuri S, Thodeti C. TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway. Oncotarget. 2016;7:25849-61 pubmed publisher
    ..shown that expression and activity of mechanosensitive ion channel transient receptor potential vanilloid 4 (TRPV4) is suppressed in tumor endothelial cells and restoring TRPV4 expression or activation induces vascular ..
  46. Kim K, Ramiro Diaz J, Iddings J, Filosa J. Vasculo-Neuronal Coupling: Retrograde Vascular Communication to Brain Neurons. J Neurosci. 2016;36:12624-12639 pubmed
    ..However, VNC was abrogated by TRPV4 channel, GABAB, as well as an adenosine A1 receptor blocker...
  47. Ruigrok H, Shahid G, Goudeau B, Poulletier de Gannes F, Poque Haro E, Hurtier A, et al. Full-Spectral Multiplexing of Bioluminescence Resonance Energy Transfer in Three TRPV Channels. Biophys J. 2017;112:87-98 pubmed publisher
    ..The BRET assay, based on the interaction with Calmodulin, was successfully extended to TRPV3 and TRPV4 channels...
  48. Teng J, Loukin S, Anishkin A, Kung C. A competing hydrophobic tug on L596 to the membrane core unlatches S4-S5 linker elbow from TRP helix and allows TRPV4 channel to open. Proc Natl Acad Sci U S A. 2016;113:11847-11852 pubmed
    ..interaction between an amino acid and inner-leaflet lipid that governs the gating transformations of TRPV4 (transient receptor potential vanilloid type 4)...
  49. Mihara H, Suzuki N, Muhammad J, Nanjo S, Ando T, Fujinami H, et al. Transient receptor potential vanilloid 4 (TRPV4) silencing in Helicobacter pylori-infected human gastric epithelium. Helicobacter. 2017;22: pubmed publisher
    ..Various stimuli activate the nonselective cation channel TRPV4, which is expressed in gastric epithelium where it detects mechanical stimuli and promotes ATP release...
  50. Ryskamp D, Frye A, Phuong T, Yarishkin O, Jo A, Xu Y, et al. TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye. Sci Rep. 2016;6:30583 pubmed publisher
    ..Here, biochemical and functional analyses localized the putative mechanosensitive cation channel TRPV4 to the plasma membrane of primary and immortalized human TM (hTM) cells, and to human and mouse TM tissue...
  51. Mistretta F, Russo A, Castiglione F, Bettiga A, Colciago G, Montorsi F, et al. DFL23448, A Novel Transient Receptor Potential Melastin 8-Selective Ion Channel Antagonist, Modifies Bladder Function and Reduces Bladder Overactivity in Awake Rats. J Pharmacol Exp Ther. 2016;356:200-11 pubmed publisher
    ..cold, but it had limited activity (IC50 > 10 μM) at transient receptor potential vanilloids TRPV1, TRPA1, or TRPV4 or at various G protein-coupled receptors...
  52. Kowal J, Yegutkin G, Novak I. ATP release, generation and hydrolysis in exocrine pancreatic duct cells. Purinergic Signal. 2015;11:533-50 pubmed publisher
    ..to drugs affecting exocytosis, pannexin-1, connexins, maxi-anion channels and transient receptor potential cation channel subfamily V member 4 (TRPV4) channels, and corresponding transcripts were expressed in duct cells...
  53. Rakers C, Schmid M, Petzold G. TRPV4 channels contribute to calcium transients in astrocytes and neurons during peri-infarct depolarizations in a stroke model. Glia. 2017;65:1550-1561 pubmed publisher
    ..In this study, we investigated the role of two astroglial membrane channels, transient receptor vanilloid 4 (TRPV4) channel and aquaporin-4 (AQP4)...
  54. Sidhaye V, Guler A, Schweitzer K, D Alessio F, Caterina M, King L. Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions. Proc Natl Acad Sci U S A. 2006;103:4747-52 pubmed
    ..Several observations indicate that TRPV4 participates in hypotonic reduction of AQP5, including a requirement for extracellular calcium to achieve AQP5 ..
  55. Matsumoto K, Yamaba R, Inoue K, Utsumi D, Tsukahara T, Amagase K, et al. Transient receptor potential vanilloid 4 channel regulates vascular endothelial permeability during colonic inflammation in dextran sulphate sodium-induced murine colitis. Br J Pharmacol. 2018;175:84-99 pubmed publisher
    The transient receptor potential vanilloid 4 (TRPV4) channel is a non-selective cation channel involved in physical sensing in various tissue types...
  56. Fujita T, Liu Y, Higashitsuji H, Itoh K, Shibasaki K, Fujita J, et al. Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins. Biochem Biophys Res Commun. 2018;495:935-940 pubmed publisher
    ..We herein report that in addition to TRPV4, TRPV3 and TRPM8 are necessary for the induction of CIPs...
  57. Szarka N, Pabbidi M, Amrein K, Czeiter E, Berta G, Pohoczky K, et al. Traumatic brain injury impairs myogenic constriction of cerebral arteries: role of mitochondria-derived H2O2 and TRPV4-dependent activation of BKCa channels. J Neurotrauma. 2017;: pubmed publisher
    ..antioxidant (mitoTEMPO), by scavenging of H2O2 (PEG-catalase) and by blocking both BKCa channels (paxilline) and TRPV4 channels (HC067047)...
  58. Taylor L, Arnér K, Ghosh F. Specific inhibition of TRPV4 enhances retinal ganglion cell survival in adult porcine retinal explants. Exp Eye Res. 2017;154:10-21 pubmed publisher
    Signaling through the polymodal cation channel Transient Receptor Potential Vanilloid 4 (TRPV4) has been implicated in retinal neuronal degeneration...
  59. Kobayakawa T, Takahashi N, Sobue Y, Terabe K, Ishiguro N, Kojima T. Mechanical stress loading induces CD44 cleavage in human chondrocytic HCS-2/8 cells. Biochem Biophys Res Commun. 2016;478:1230-5 pubmed publisher
    ..Chemical inhibition of transient receptor potential vanilloid 4 (TRPV4) significantly suppressed CTS loading-induced ADAM10 expression and CD44 cleavage...
  60. Köttgen M, Benzing T, Simmen T, Tauber R, Buchholz B, Feliciangeli S, et al. Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J. 2005;24:705-16 pubmed
    ..Furthermore, PACS proteins may represent a novel molecular mechanism for ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. ..
  61. Benfenati V, Caprini M, Dovizio M, Mylonakou M, Ferroni S, Ottersen O, et al. An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes. Proc Natl Acad Sci U S A. 2011;108:2563-8 pubmed publisher
    ..Here we show that a complex containing aquaporin-4 (AQP4) and transient receptor potential vanilloid 4 (TRPV4) is essential for RVD in astrocytes...
  62. Ueda T, Shikano M, Kamiya T, Joh T, Ugawa S. The TRPV4 channel is a novel regulator of intracellular Ca2+ in human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2011;301:G138-47 pubmed publisher
    ..Transient receptor potential vanilloid 4 (TRPV4) is a Ca(2+)-permeable channel that is activated by extracellular hypotonicity, polyunsaturated fatty acids, ..
  63. Walter B, Purmessur D, Moon A, Occhiogrosso J, Laudier D, Hecht A, et al. Reduced tissue osmolarity increases TRPV4 expression and pro-inflammatory cytokines in intervertebral disc cells. Eur Cell Mater. 2016;32:123-36 pubmed
    ..This study tested the hypothesis that changes in osmo-sensation by the transient receptor potential vallinoid-4 (TRPV4) ion channel occur with disease and contribute to the inflammatory environment found during degeneration...
  64. Greenberg H, Carlton Carew S, Khan D, Zargaran A, Jahan K, Vanessa Ho W, et al. Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced nitric oxide production and vasorelaxation in rabbit mesenteric arteries. Vascul Pharmacol. 2017;96-98:53-62 pubmed publisher
    ..The present study investigates the potential role of heteromeric TRPV4-TRPC1 channels in mediating these CaSR-induced vascular responses...