TRPM8

Summary

Gene Symbol: TRPM8
Description: transient receptor potential cation channel subfamily M member 8
Alias: LTRPC6, LTrpC-6, TRPP8, trp-p8, transient receptor potential cation channel subfamily M member 8, TRPM8 cationic channel, transient receptor potential p8, transient receptor potential subfamily M member 8
Species: human
Products:     TRPM8

Top Publications

  1. Chasman D, Schürks M, Anttila V, de Vries B, Schminke U, Launer L, et al. Genome-wide association study reveals three susceptibility loci for common migraine in the general population. Nat Genet. 2011;43:695-8 pubmed publisher
    ..32, PRDM16), rs10166942 (2q37.1, TRPM8) and rs11172113 (12q13.3, LRP1) were among the top seven associations (P < 5 × 10(-6)) with migraine...
  2. Pedretti A, Marconi C, Bettinelli I, Vistoli G. Comparative modeling of the quaternary structure for the human TRPM8 channel and analysis of its binding features. Biochim Biophys Acta. 2009;1788:973-82 pubmed publisher
    The aim of this study was to generate a reliable model for the homotetrameric structure of the human TRPM8 cation channel, a temperature sensor involved in innocuous cold perceptions...
  3. Sabnis A, Shadid M, Yost G, Reilly C. Human lung epithelial cells express a functional cold-sensing TRPM8 variant. Am J Respir Cell Mol Biol. 2008;39:466-74 pubmed publisher
    ..Chemical agonists of TRP channels, including menthol and capsaicin, also elicit sensations of temperature change. TRPM8 is a cold- and menthol-sensing ion channel that converts thermal and chemical stimuli into neuronal signals and ..
  4. Bidaux G, Flourakis M, Thebault S, Zholos A, Beck B, Gkika D, et al. Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function. J Clin Invest. 2007;117:1647-57 pubmed
    In recent years, the transient receptor potential melastatin member 8 (TRPM8) channel has emerged as a promising prognostic marker and putative therapeutic target in prostate cancer (PCa)...
  5. Wondergem R, Ecay T, Mahieu F, Owsianik G, Nilius B. HGF/SF and menthol increase human glioblastoma cell calcium and migration. Biochem Biophys Res Commun. 2008;372:210-5 pubmed publisher
    This study explored the role of transient receptor potential melastatin 8 ion channels (TRPM8) in mechanisms of human glioblastoma (DBTRG) cell migration...
  6. Kühn F, Witschas K, Kühn C, Lückhoff A. Contribution of the S5-pore-S6 domain to the gating characteristics of the cation channels TRPM2 and TRPM8. J Biol Chem. 2010;285:26806-14 pubmed publisher
    The closely related cation channels TRPM2 and TRPM8 show completely different requirements for stimulation and are regulated by Ca(2+) in an opposite manner...
  7. Zakharian E, Thyagarajan B, French R, Pavlov E, Rohacs T. Inorganic polyphosphate modulates TRPM8 channels. PLoS ONE. 2009;4:e5404 pubmed publisher
    ..Here we investigated the role of polyP in the function of the transient receptor potential melastatin 8 (TRPM8) channel...
  8. De Blas G, Darszon A, Ocampo A, Serrano C, Castellano L, Hernández González E, et al. TRPM8, a versatile channel in human sperm. PLoS ONE. 2009;4:e6095 pubmed publisher
    ..Here we document with RT-PCR, western blot and immunocitochemistry analysis the presence of TRPM8 in human sperm...
  9. Yang Z, Wang X, Wang H, Hu L. Effects of TRPM8 on the proliferation and motility of prostate cancer PC-3 cells. Asian J Androl. 2009;11:157-65 pubmed publisher
    We investigated the effects of transient receptor potential M8 (TRPM8) channel on the proliferation and motility of androgen-independent prostate cancer PC-3 cells...

More Information

Publications100

  1. Yamamura H, Ugawa S, Ueda T, Morita A, Shimada S. TRPM8 activation suppresses cellular viability in human melanoma. Am J Physiol Cell Physiol. 2008;295:C296-301 pubmed publisher
    ..Among this subfamily, TRPM8 (also known as Trp-p8) is a Ca(2+)-permeable channel that was originally identified as a prostate-specific gene ..
  2. Mahieu F, Owsianik G, Verbert L, Janssens A, De Smedt H, Nilius B, et al. TRPM8-independent menthol-induced Ca2+ release from endoplasmic reticulum and Golgi. J Biol Chem. 2007;282:3325-36 pubmed
    ..induces Ca2+ influx in a subset of sensory neurons from dorsal root and trigeminal ganglia, due to activation of TRPM8, a Ca2+-permeable, cold-activated member of the TRP superfamily of cation channels...
  3. Valero M, Morenilla Palao C, Belmonte C, Viana F. Pharmacological and functional properties of TRPM8 channels in prostate tumor cells. Pflugers Arch. 2011;461:99-114 pubmed publisher
    Prostate cancer (PC) is a major health problem in adult males. TRPM8, a cationic TRP channel activated by cooling and menthol is upregulated in PC. However, the precise role of TRPM8 in PC is still unclear...
  4. Brauchi S, Orio P, Latorre R. Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8. Proc Natl Acad Sci U S A. 2004;101:15494-9 pubmed
    The cold and menthol receptor, TRPM8, also designated CMR1, is a member of the transient receptor potential (TRP) family of excitatory ion channels. TRPM8 is a channel activated by cold temperatures, voltage, and menthol...
  5. Bödding M, Wissenbach U, Flockerzi V. Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium. 2007;42:618-28 pubmed
    ..One member of the melastatin (M) group, namely TRPM8 is activated by cold and cooling compounds such as menthol and icilin, and its gene is up-regulated in prostate ..
  6. Voets T, Owsianik G, Nilius B. TRPM8. Handb Exp Pharmacol. 2007;:329-44 pubmed
    Originally cloned as a prostate-specific protein, TRPM8 is now best known as a cold- and menthol-activated channel implicated in thermosensation...
  7. Erler I, Al Ansary D, Wissenbach U, Wagner T, Flockerzi V, Niemeyer B. Trafficking and assembly of the cold-sensitive TRPM8 channel. J Biol Chem. 2006;281:38396-404 pubmed
    ..Common to each TRPM member is a prominent C-terminal coiled coil region. Here we have shown that TRPM8 channels assemble as multimers using the putative coiled coil region within the intracellular C terminus and that ..
  8. Voets T, Droogmans G, Wissenbach U, Janssens A, Flockerzi V, Nilius B. The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature. 2004;430:748-54 pubmed
    ..Here we show that temperature sensing is tightly linked to voltage-dependent gating in the cold-sensitive channel TRPM8 and the heat-sensitive channel TRPV1...
  9. Chodon D, Guilbert A, Dhennin Duthille I, Gautier M, Telliez M, Sevestre H, et al. Estrogen regulation of TRPM8 expression in breast cancer cells. BMC Cancer. 2010;10:212 pubmed publisher
    The calcium-permeable cation channel TRPM8 (melastatin-related transient receptor potential member 8) is over-expressed in several cancers...
  10. Thebault S, Lemonnier L, Bidaux G, Flourakis M, Bavencoffe A, Gordienko D, et al. Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells. J Biol Chem. 2005;280:39423-35 pubmed
    Recent cloning of a cold/menthol-sensitive TRPM8 channel (transient receptor potential melastatine family member 8) from rodent sensory neurons has provided the molecular basis for the cold sensation...
  11. Tsavaler L, Shapero M, Morkowski S, Laus R. Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res. 2001;61:3760-9 pubmed
  12. Gkika D, Flourakis M, Lemonnier L, Prevarskaya N. PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression. Oncogene. 2010;29:4611-6 pubmed publisher
    Although the transient receptor potential melastatin 8 (TRPM8) cold receptor is highly expressed in prostate cancer (PCa) and constitutes a promising diagnostic and prognostic indicator, the natural agonists of this channel in the ..
  13. Peier A, Moqrich A, Hergarden A, Reeve A, Andersson D, Story G, et al. A TRP channel that senses cold stimuli and menthol. Cell. 2002;108:705-15 pubmed
    ..Here we describe the cloning and characterization of TRPM8, a distant relative of VR1. TRPM8 is specifically expressed in a subset of pain- and temperature-sensing neurons...
  14. Bidaux G, Roudbaraki M, Merle C, Crepin A, Delcourt P, Slomianny C, et al. Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement. Endocr Relat Cancer. 2005;12:367-82 pubmed
    b>TRPM8 (melastatine-related transient receptor potential member 8), a member of the transient receptor potential (TRP) superfamily of cation channels, has been shown to be a calcium-channel protein...
  15. Kiessling A, Fussel S, Schmitz M, Stevanovic S, Meye A, Weigle B, et al. Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8. Prostate. 2003;56:270-9 pubmed
    ..Our results suggest this antigen as a suitable target for the T-cell-based immunotherapy of PCa. ..
  16. Bai V, Murthy S, Chinnakannu K, Muhletaler F, Tejwani S, Barrack E, et al. Androgen regulated TRPM8 expression: a potential mRNA marker for metastatic prostate cancer detection in body fluids. Int J Oncol. 2010;36:443-50 pubmed
    ..We identified an RNA transcript with sequence homology to TRPM8 (melastatin-related transient receptor potential member 8) that was overexpressed in tumor vs...
  17. Ebihara S, Ebihara T, Gui P, Osaka K, Sumi Y, Kohzuki M. Thermal taste and anti-aspiration drugs: a novel drug discovery against pneumonia. Curr Pharm Des. 2014;20:2755-9 pubmed
    ..Red wine polyphenols improved swallowing reflex by enhancing TRPV1 response. Food with menthol, agonist of TRPM8 which is a cold temperature receptor, also decreased the delay in swallowing reflex...
  18. Patel R, Bauer C, Nieto Rostro M, Margas W, Ferron L, Chaggar K, et al. α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage. J Neurosci. 2013;33:16412-26 pubmed publisher
    ..Furthermore, a significantly smaller number of DRG neurons respond to the TRPM8 agonist menthol...
  19. Craighead D, Alexander L. Topical menthol increases cutaneous blood flow. Microvasc Res. 2016;107:39-45 pubmed publisher
    ..active ingredient in several topically applied analgesics, activates transient receptor potential melastatin 8 (TRPM8) receptors on sensory nerves and on the vasculature inducing a cooling sensation on the skin...
  20. Amato A, Serio R, Mulè F. Involvement of cholinergic nicotinic receptors in the menthol-induced gastric relaxation. Eur J Pharmacol. 2014;745:129-34 pubmed publisher
    ..with neural receptors or ionic channels proteins, such as transient receptor potential (TRP)-melastatin8 (TRPM8), TRP-ankyrin 1 (TRPA1), 5-hydroxytriptamine 3 (5-HT3) receptor or cholinergic nicotinic receptors...
  21. Morenilla Palao C, Luis E, Fernández Peña C, Quintero E, Weaver J, Bayliss D, et al. Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation. Cell Rep. 2014;8:1571-82 pubmed publisher
    Animals sense cold ambient temperatures through the activation of peripheral thermoreceptors that express TRPM8, a cold- and menthol-activated ion channel...
  22. da Silva Serra I, Husson Z, Bartlett J, Smith E. Characterization of cutaneous and articular sensory neurons. Mol Pain. 2016;12: pubmed publisher
    ..1 (TRPV1), transient receptor potential ankyrin 1 (TRPA1), and transient receptor potential melastatin 8 (TRPM8), respectively. By contrast, significantly more articular neurons responded to ATP than cutaneous neurons...
  23. Rosendahl J, Braun H, Schrapers K, Martens H, Stumpff F. Evidence for the functional involvement of members of the TRP channel family in the uptake of Na(+) and NH4 (+) by the ruminal epithelium. Pflugers Arch. 2016;468:1333-52 pubmed publisher
    ..No bands were detected for TRPV1, TRPV5, or TRPM8. Functional and molecular biological data suggest that the transport of NH4 (+), Na(+), and Ca(2+) across the ..
  24. Simões R, Dos Santos Coelho I, do Espírito Santo C, Morel A, Zanchet E, Santos A. Oral treatment with methanolic extract of the root bark of Condalia buxifolia Reissek alleviates acute pain and inflammation in mice: Potential interactions with PGE2, TRPV1/ASIC and PKA signaling pathways. J Ethnopharmacol. 2016;185:319-26 pubmed publisher
    ..g.) to mice on nociception induced by capsaicin (TRPV1 agonist), cinnamaldehyde (TRPA1 agonist), menthol (TRPM8 agonist), acidified saline (ASIC agonist), PMA (protein kinase C activator), PGE2 and forskolin (protein kinase A ..
  25. Liu B, Tai Y, Caceres A, Achanta S, Balakrishna S, Shao X, et al. Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice. PLoS ONE. 2016;11:e0165200 pubmed publisher
    ..channels expressed in HEK293 cells in vitro, without any effect on other TRP channels, including TRPV1, TRPV4 and TRPM8. OxPAPC agonist activity was dependent on essential cysteine and lysine residues within the N-terminus of the ..
  26. Paschke M, Tkachenko A, Ackermann K, Hutzler C, Henkler F, Luch A. Activation of the cold-receptor TRPM8 by low levels of menthol in tobacco products. Toxicol Lett. 2017;271:50-57 pubmed publisher
    Activation of the cold-receptor TRPM8 by menthol or other tobacco additives can suppress natural defense reactions such as coughing that usually would become effective as involuntary resistance against the inhalation of fumes...
  27. Hsieh Y, Chen H, Yang C, Yang C. Analgesic Effects of Transcutaneous Ultrasound Nerve Stimulation in a Rat Model of Oxaliplatin-Induced Mechanical Hyperalgesia and Cold Allodynia. Ultrasound Med Biol. 2017;43:1466-1475 pubmed publisher
    ..Sensory behavioral examinations, protein levels of transient receptor potential channels (TRPM8 and TRPV1) in dorsal root ganglia (DRG) and substance P (SP) in spinal dorsal horn were examined...
  28. Andersson K. Potential Future Pharmacological Treatment of Bladder Dysfunction. Basic Clin Pharmacol Toxicol. 2016;119 Suppl 3:75-85 pubmed publisher
    ..tract have indicated that several transient receptor potential (TRP) channels, including TRPV1, TRPV2, TRPV4, TRPM8 and TRPA1, are expressed in the bladder and may act as sensors of stretch and/or chemical irritation...
  29. Beccari A, Gemei M, Lo Monte M, Menegatti N, Fanton M, Pedretti A, et al. Publisher Correction: Novel selective, potent naphthyl TRPM8 antagonists identified through a combined ligand- and structure-based virtual screening approach. Sci Rep. 2018;8:4250 pubmed publisher
    ..A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ..
  30. Fernandez J, Skryma R, Bidaux G, Magleby K, Scholfield C, McGeown J, et al. Short isoforms of the cold receptor TRPM8 inhibit channel gating by mimicking heat action rather than chemical inhibitors. J Biol Chem. 2012;287:2963-70 pubmed publisher
    ..They also integrate multiple stimuli through their typically polymodal activation. Thus, although the TRPM8 channel has been extensively investigated as the major neuronal cold sensor, it is also regulated by various ..
  31. Beckmann H, Richter J, Hill K, Urban N, Lemoine H, Schaefer M. A benzothiadiazine derivative and methylprednisolone are novel and selective activators of transient receptor potential canonical 5 (TRPC5) channels. Cell Calcium. 2017;66:10-18 pubmed publisher
    ..On the main sensory TRP channels (TRPA1, TRPV1, TRPM3, TRPM8) BTD exerts only minor activity...
  32. Su L, Shu R, Song C, Yu Y, Wang G, Li Y, et al. Downregulations of TRPM8 expression and membrane trafficking in dorsal root ganglion mediate the attenuation of cold hyperalgesia in CCI rats induced by GFR?3 knockdown. Brain Res Bull. 2017;135:8-24 pubmed publisher
    ..have previously demonstrated the contribution of enhanced activity of transient receptor potential melastatin 8 (TRPM8) to cold hyperalgesia in neuropathic pain using a rat model of chronic constriction injury (CCI) to the sciatic ..
  33. Gong K, Jasmin L. Sustained Morphine Administration Induces TRPM8-Dependent Cold Hyperalgesia. J Pain. 2017;18:212-221 pubmed publisher
    ..Here we present evidence that the cold sensor TRPM8 channel is involved in opioid-induced hyperalgesia...
  34. Shah A, Montagne J, Oh S, Wigley F, Casciola Rosen L. Pilot study to determine whether transient receptor potential melastatin type 8 (TRPM8) antibodies are detected in scleroderma. Clin Exp Rheumatol. 2015;33:S123-6 pubmed
    A key mediator in cold-sensation is the protein transient receptor potential melastatin 8 (TRPM8), which is expressed on sensory nerves and cutaneous blood vessels...
  35. Genova T, Grolez G, Camillo C, Bernardini M, Bokhobza A, Richard E, et al. TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1. J Cell Biol. 2017;216:2107-2130 pubmed publisher
    ..The TRPM8 channel has recently been proposed to play a protective role in prostate cancer by impairing cell motility...
  36. Corcoran P, Hollander D, Ousler G, Angjeli E, Rimmer D, Lane K, et al. Dynamic Sensitivity of Corneal TRPM8 Receptors to Menthol Instillation in Dry Eye Versus Normal Subjects. J Ocul Pharmacol Ther. 2017;33:686-692 pubmed publisher
    To assess the sensitivity of corneal cold receptors to a known transient receptor potential melastatin 8 (TRPM8) agonist, menthol, in dry eye and normals, and to determine whether factors such as disease duration or age affect responses.
  37. Yajima T, Sato T, Hosokawa H, Kondo T, Saito M, Shimauchi H, et al. Distribution of transient receptor potential melastatin-8-containing nerve fibers in rat oral and craniofacial structures. Ann Anat. 2015;201:1-5 pubmed publisher
    The transient receptor potential melastatin-8 (TRPM8) is a cold and menthol receptor located in the sensory ganglia. Immunohistochemistry for TRPM8 was performed on oral and craniofacial structures of the rat...
  38. Qin D, Zou Z, Zhou C, Mu F. [Role of transient receptor potential melastatin 8 channels in migraine mechanism in rats]. Zhongguo Dang Dai Er Ke Za Zhi. 2015;17:515-9 pubmed
    To investigate the role of transient receptor potential melastatin 8 (TRPM8) channels in migraine mechanism in rats by measuring the changes in expression of TRPM8 in the trigeminal nerve of rats with migraine...
  39. Urata T, Mori N, Fukuwatari T. Vagus nerve is involved in the changes in body temperature induced by intragastric administration of 1,8-cineole via TRPM8 in mice. Neurosci Lett. 2017;650:65-71 pubmed publisher
    Transient Receptor Potential Melastatin 8 (TRPM8) is a cold receptor activated by mild cold temperature (<28°C). TRPM8 expressed in cutaneous sensory nerves is involved in cold sensation and thermoregulation...
  40. Kozyreva T, Tkachenko E, Potapova T, Voevoda M. [Respiratory system response to cooling in subjects with single nucleotide polymorphism rs11562975 in gene of thermosensitive TRPM8 ion channel]. Fiziol Cheloveka. 2014;40:94-8 pubmed
    ..nucleotide polymorphism rs11562975, located in 6 exon of the gene encoding the temperature-sensitive ion channel TRPM8. Subjects with heterozygous genotype GC were characterized by not only increased sensation to cold but also ..
  41. Yu X, Yu M, Liu Y, Yu S. TRP channel functions in the gastrointestinal tract. Semin Immunopathol. 2016;38:385-96 pubmed publisher
    ..In this review, we focus on the expressions and functions of TRPV1, TRPA1, and TRPM8 in primary extrinsic afferent nerves innervated in the esophagus, stomach, intestine, and colon and briefly ..
  42. Sakai K, Sanders K, Youssef M, Yanushefski K, JENSEN L, Yosipovitch G, et al. Mouse model of imiquimod-induced psoriatic itch. Pain. 2016;157:2536-2543 pubmed
    ..TRPV4 mRNA expression was transiently increased in the DRG cells, whereas TRPM8 mRNA was significantly decreased...
  43. Uchida K, Dezaki K, Yoneshiro T, Watanabe T, Yamazaki J, Saito M, et al. Involvement of thermosensitive TRP channels in energy metabolism. J Physiol Sci. 2017;67:549-560 pubmed publisher
    ..Moreover, TRPA1- and TRPM8-expressing sensory nerves also contribute to potentiation of BAT thermogenesis and energy expenditure in mice...
  44. Wang S, Zhang D, Hu J, Jia Q, Xu W, Su D, et al. A clinical and mechanistic study of topical borneol-induced analgesia. EMBO Mol Med. 2017;9:802-815 pubmed publisher
    ..Using mouse models of pain, we identified the TRPM8 channel as a molecular target of borneol and showed that topical borneol-induced analgesia was almost exclusively ..
  45. Huang F, Ni M, Zhang J, Li D, Shen F. TRPM8 downregulation by angiotensin II in vascular smooth muscle cells is involved in hypertension. Mol Med Rep. 2017;15:1900-1908 pubmed publisher
    ..Transient receptor potential melastatin 8 (TRPM8) is a thermally?regulated Ca2+?permeable channel that is activated by reduced body temperature...
  46. Louhivuori L, Bart G, Larsson K, Louhivuori V, Näsman J, Nordström T, et al. Differentiation dependent expression of TRPA1 and TRPM8 channels in IMR-32 human neuroblastoma cells. J Cell Physiol. 2009;221:67-74 pubmed publisher
    TRPA1 and TRPM8 are transient receptor potential (TRP) channels involved in sensory perception. TRPA1 is a non-selective calcium permeable channel activated by irritants and proalgesic agents...
  47. Xiong M, Wang J, Guo M, Zhou Q, Lu W. TRPM8 genetic variations associated with COPD risk in the Chinese Han population. Int J Chron Obstruct Pulmon Dis. 2016;11:2563-2571 pubmed
    i>TRPM8 plays a key role in COPD. The development of pulmonary hypertension (PH) in COPD adversely affects survival and exercise capacity...
  48. Sághy Ã, SzÅ‘ke Ã, Payrits M, Helyes Z, Börzsei R, Erostyák J, et al. Evidence for the role of lipid rafts and sphingomyelin in Ca2+-gating of Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve terminals. Pharmacol Res. 2015;100:101-16 pubmed publisher
    ..Two "melastatin" TRP receptors, like TRPM8 and TRPM3 are also expressed in a subgroup of primary sensory neurons...
  49. Zheng W, Hu R, Cai R, Hofmann L, Hu Q, Fatehi M, et al. Identification and characterization of hydrophobic gate residues in TRP channels. FASEB J. 2017;: pubmed publisher
    ..strategy, we identified a hydrophobic single-residue gate in TRPV4Iso715, TRPC4Iso617, and TRPM8Val976 In support of the hydrophobic gate theory, hydrophilic substitution at the gate site, which ..
  50. Mistretta F, Russo A, Castiglione F, Bettiga A, Colciago G, Montorsi F, et al. DFL23448, A Novel Transient Receptor Potential Melastin 8-Selective Ion Channel Antagonist, Modifies Bladder Function and Reduces Bladder Overactivity in Awake Rats. J Pharmacol Exp Ther. 2016;356:200-11 pubmed publisher
    The transient receptor potential melastin 8 ion channel (TRPM8) is implicated in bladder sensing but limited information on TRPM8 antagonists in bladder overactivity is available...
  51. Naziroglu M, Blum W, Jósvay K, Ciğ B, Henzi T, Olah Z, et al. Menthol evokes Ca2+ signals and induces oxidative stress independently of the presence of TRPM8 (menthol) receptor in cancer cells. Redox Biol. 2018;14:439-449 pubmed publisher
    ..50-500µM) was predicted to be mediated by the transient receptor potential ion channel melastatin subtype 8 (TRPM8)...
  52. Mergler S, Derckx R, Reinach P, Garreis F, Böhm A, Schmelzer L, et al. Calcium regulation by temperature-sensitive transient receptor potential channels in human uveal melanoma cells. Cell Signal. 2014;26:56-69 pubmed publisher
    ..In UM cells, TRPV1 and TRPM8 gene expression was identified...
  53. Yin Y, Wu M, Zubcevic L, Borschel W, Lander G, Lee S. Structure of the cold- and menthol-sensing ion channel TRPM8. Science. 2018;359:237-241 pubmed publisher
    ..Within the TRPM family, member 8 (TRPM8) is the primary cold and menthol sensor in humans...
  54. Pan Y, Chen F, Huang S, Cai Z, Lan H, Tong Y, et al. TRPA1 and TRPM8 Receptors May Promote Local Vasodilation that Aggravates Oxaliplatin-Induced Peripheral Neuropathy Amenable to 17?-Estradiol Treatment. Curr Neurovasc Res. 2016;13:309-317 pubmed
    ..transient receptor potential ankyrin 1 (TRPA1) antagonist HC033031 or transient receptor potential melastatin 8 (TRPM8) antagonist AMTB using laser Doppler flowmetry...
  55. Tai Y, Wang C, Wang Z, Liang Y, Du J, He D, et al. Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone. Sci Rep. 2017;7:7532 pubmed publisher
    ..HQ failed to activate TRPV1, TRPV4 or TRPM8. HQ-induced TRPA1 activation was dependent on essential redox-sensitive cysteine and lysine residues within N-..
  56. Jankowski M, Rau K, Koerber H. Cutaneous TRPM8-expressing sensory afferents are a small population of neurons with unique firing properties. Physiol Rep. 2017;5: pubmed publisher
    It has been well documented that the transient receptor potential melastatin 8 (TRPM8) receptor is involved in environmental cold detection...
  57. Moraes M, de Assis L, Henriques F, Batista M, Guler A, Castrucci A. Cold-sensing TRPM8 channel participates in circadian control of the brown adipose tissue. Biochim Biophys Acta Mol Cell Res. 2017;1864:2415-2427 pubmed publisher
    Transient receptor potential (TRP) channels are known to regulate energy metabolism, and TRPM8 has become an interesting player in this context...
  58. Xiong S, Wang B, Lin S, Zhang H, Li Y, Wei X, et al. Activation of Transient Receptor Potential Melastatin Subtype 8 Attenuates Cold-Induced Hypertension Through Ameliorating Vascular Mitochondrial Dysfunction. J Am Heart Assoc. 2017;6: pubmed publisher
    ..Transient receptor potential melastatin subtype 8 (TRPM8) is a mild cold-sensing nonselective cation channel that is activated by menthol...
  59. Takashima Y, Daniels R, Knowlton W, Teng J, Liman E, McKemy D. Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons. J Neurosci. 2007;27:14147-57 pubmed
    ..cold responses in vivo are dependent on the cold and menthol receptor transient receptor potential melastatin 8 (TRPM8)...
  60. El Karim I, Linden G, Curtis T, About I, McGahon M, Irwin C, et al. Human dental pulp fibroblasts express the "cold-sensing" transient receptor potential channels TRPA1 and TRPM8. J Endod. 2011;37:473-8 pubmed publisher
    ..b>TRPM8 and TRPA1 are cold-sensing TRP channels activated by moderate cooling and noxious cold temperatures, respectively...
  61. Than J, Li L, Hasan R, Zhang X. Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel-expressing sensory neurons by the pruritogen chloroquine. J Biol Chem. 2013;288:12818-27 pubmed publisher
    ..TRPV1 and TRPA1 channels transduce pain and itch, whereas TRPM8 transduces cold. The pruritogen chloroquine (CQ) was reported to excite TRPA1, leading to the sensation of itch...
  62. Düzen I, Yavuz F, Vuruşkan E, Saraçoğlu E, Poyraz F, Goksuluk H, et al. Leukocyte TRP channel gene expressions in patients with non-valvular atrial fibrillation. Sci Rep. 2017;7:9272 pubmed publisher
    ..in MCOLN1 (TRPML1), MCOLN2 (TRPML2), MCOLN3 (TRPML3), TRPA1, TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8, TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, TRPC7, TRPV1, TRPV2, TRPV3, TRPV4, TRPV5, TRPV6, and PKD2 (TRPP2) gene ..
  63. Pollastro F, Caprioglio D, Marotta P, Moriello A, De Petrocellis L, Taglialatela Scafati O, et al. Iodine-Promoted Aromatization of p-Menthane-Type Phytocannabinoids. J Nat Prod. 2017;: pubmed publisher
    ..thermo-TRPs) biological end-points of phytocannabinoids, retained the submicromolar TRPA1-activating and TRPM8-inhibiting properties of CBN, while also potently activating TRPV2...
  64. Bidaux G, Borowiec A, Prevarskaya N, Gordienko D. Fine-tuning of eTRPM8 expression and activity conditions keratinocyte fate. Channels (Austin). 2016;10:320-31 pubmed publisher
    Recently, we reported the cloning and characterization of short isoform of the icilin-activated cold receptor TRPM8 channel in keratinocytes, dubbed eTRPM8...
  65. Xiao N, Jiang L, Ge B, Zhang T, Zhao X, Zhou X. Over-expression of TRPM8 is associated with poor prognosis in urothelial carcinoma of bladder. Tumour Biol. 2014;35:11499-504 pubmed publisher
    ..We firstly investigated TRP channel melastatin 8 (TRPM8) expression in urothelial carcinoma of bladder (UCB) and its correlation with UCB clinicopathological features and ..
  66. Eguchi H, Hiura A, Nakagawa H, Kusaka S, Shimomura Y. Corneal Nerve Fiber Structure, Its Role in Corneal Function, and Its Changes in Corneal Diseases. Biomed Res Int. 2017;2017:3242649 pubmed publisher
    ..Besides the corneal nerve fibers, the expressions of TRPV (1, 3, and 4), TRPC (canonical) 4, and TRPM8 are demonstrated in the corneal epithelial cell membrane...
  67. Veliz L, Toro C, Vivar J, Arias L, Villegas J, Castro M, et al. Near-membrane dynamics and capture of TRPM8 channels within transient confinement domains. PLoS ONE. 2010;5:e13290 pubmed publisher
    The cold and menthol receptor, TRPM8, is a non-selective cation channel expressed in a subset of peripheral neurons that is responsible for neuronal detection of environmental cold stimuli...
  68. Mergler S, Strowski M, Kaiser S, Plath T, Giesecke Y, Neumann M, et al. Transient receptor potential channel TRPM8 agonists stimulate calcium influx and neurotensin secretion in neuroendocrine tumor cells. Neuroendocrinology. 2007;85:81-92 pubmed
    b>TRPM8 is a member of the melastatin-type transient receptor potential ion channel family. Activation by cold or by agonists (menthol, icilin) induces a transient rise in intracellular free calcium concentration ([Ca(2+)](i))...
  69. Chen J, Kim D, Bianchi B, Cavanaugh E, Faltynek C, Kym P, et al. Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol Pain. 2009;5:3 pubmed publisher
    Abundantly expressed in pain-sensing neurons, TRPV1, TRPA1 and TRPM8 are major cellular sensors of thermal, chemical and mechanical stimuli...
  70. Harrison E, Biswas L, Avusula R, Zhang M, Gong Y, Liu X. Effects of menthol and its interaction with nicotine-conditioned cue on nicotine-seeking behavior in rats. Psychopharmacology (Berl). 2017;234:3443-3453 pubmed publisher
    ..In a subset of nicotine-trained rats, a transient receptor potential melastatin 8 (TRPM8) antagonist RQ-00203078 was given prior to menthol administration...
  71. Gkika D, Lemonnier L, Shapovalov G, Gordienko D, Poux C, Bernardini M, et al. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. J Cell Biol. 2015;208:89-107 pubmed publisher
    b>TRPM8 is a cold sensor that is highly expressed in the prostate as well as in other non-temperature-sensing organs, and is regulated by downstream receptor-activated signaling pathways...
  72. Luo X, Li M, Zhan K, Yang W, Zhang L, Wang K, et al. Selective inhibition of TRPM2 channel by two novel synthesized ADPR analogues. Chem Biol Drug Des. 2017;: pubmed publisher
    ..7 and 5.4 ?m, respectively. Both 7i and 8a inhibited TRPM2 current without affecting TRPM7, TRPM8, TRPV1 and TRPV3...
  73. Namer B, Kleggetveit I, Handwerker H, Schmelz M, Jorum E. Role of TRPM8 and TRPA1 for cold allodynia in patients with cold injury. Pain. 2008;139:63-72 pubmed publisher
    Local cold injury often induces hypersensitivity to cold and cold allodynia. Sensitisation of TRPM8 or TRPA1 could be the underlying mechanisms...
  74. Van Haute C, De Ridder D, Nilius B. TRP channels in human prostate. ScientificWorldJournal. 2010;10:1597-611 pubmed publisher
    ..Controversial data regarding the expression pattern and the potential impact of TRP channels in prostate function, and their involvement in prostate cancer and other prostate diseases, will be discussed. ..
  75. Fujita T, Liu Y, Higashitsuji H, Itoh K, Shibasaki K, Fujita J, et al. Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins. Biochem Biophys Res Commun. 2018;495:935-940 pubmed publisher
    ..We herein report that in addition to TRPV4, TRPV3 and TRPM8 are necessary for the induction of CIPs...
  76. Lamb J, Romero E, Lu Z, Marcus S, Peterson H, Veranth J, et al. Activation of Human Transient Receptor Potential Melastatin-8 (TRPM8) by Calcium-Rich Particulate Materials and Effects on Human Lung Cells. Mol Pharmacol. 2017;92:653-664 pubmed publisher
    ..We report that human transient receptor potential melastatin-8 (TRPM8) and an N-terminally truncated TRPM8 variant (TRPM8-?801) are activated by CFA and calcium-rich nanoparticles and/..
  77. Hui K, Guo Y, Feng Z. Biophysical properties of menthol-activated cold receptor TRPM8 channels. Biochem Biophys Res Commun. 2005;333:374-82 pubmed
    The temperature-sensitive transient receptor potential channel, TRPM8, was recently cloned and found to be activated by cold and menthol...
  78. Rath P, Hilton J, Sisco N, Van Horn W. Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain. Biochemistry. 2016;55:114-24 pubmed publisher
    The transient receptor potential melastatin 8 (TRPM8) ion channel is the primary cold sensor in humans...
  79. Yu X, Hu Y, Ru F, Kollarik M, Undem B, Yu S. TRPM8 function and expression in vagal sensory neurons and afferent nerves innervating guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2015;308:G489-96 pubmed publisher
    Sensory transduction in esophageal afferents requires specific ion channels and receptors. TRPM8 is a new member of the transient receptor potential (TRP) channel family and participates in cold- and menthol-induced sensory transduction, ..
  80. Potapova T, Babenko V, Kobzev V, Romashchenko A, Maksimov V, Voevoda M. Associations of cold receptor TRPM8 gene single nucleotide polymorphism with blood lipids and anthropometric parameters in Russian population. Bull Exp Biol Med. 2014;157:757-61 pubmed publisher
    ..R247T), rs11562975 (L250L), rs7593557 (S419N), rs11563208 (I1016I), and rs11563071 (V1058V) of the cold receptor TRPM8 (2q37...
  81. Du G, Li J, Liu W, Liu Y, Zhao B, Li H, et al. The combination of TRPM8 and TRPA1 expression causes an invasive phenotype in lung cancer. Tumour Biol. 2014;35:1251-61 pubmed publisher
    ..tumor progression and that the molecular sensors for cold are the transient receptor potential (TRP) channels TRPM8 and TRPA1...
  82. Li M, Perelman J, Kolosov V, Zhou X. [Effects of transient receptor potential melastatin 8 cation channels on inflammatory reaction induced by cold temperatures in human airway epithelial cells]. Zhonghua Jie He He Hu Xi Za Zhi. 2011;34:757-61 pubmed
    To explore the role of transient receptor potential melastatin 8 cation channels (TRPM8) in cold-induced production of inflammatory factors in airway epithelial cells and related signal transduction mechanism...
  83. Yudin Y, Lutz B, Tao Y, Rohacs T. Phospholipase C ?4 regulates cold sensitivity in mice. J Physiol. 2016;594:3609-28 pubmed publisher
    The cold- and menthol-activated transient receptor potential melastatin 8 (TRPM8) channels are thought to be regulated by phospholipase C (PLC), but neither the specific PLC isoform nor the in vivo relevance of this regulation has been ..
  84. Craighead D, Alexander L. Menthol-Induced Cutaneous Vasodilation Is Preserved in Essential Hypertensive Men and Women. Am J Hypertens. 2017;30:1156-1162 pubmed publisher
    Menthol is a selective transient receptor potential melastatin 8 (TRPM8) channel agonist that induces cutaneous vasodilation in young, normotensive men and women through nitric oxide synthase (NOS)-, endothelium-derived hyperpolarizing ..
  85. Liu Y, Qin N. TRPM8 in health and disease: cold sensing and beyond. Adv Exp Med Biol. 2011;704:185-208 pubmed publisher
    This review focuses on TRPM8, one of the approximately 30 members of the diverse family of transient receptor potential (TRP) ion channels...
  86. Klasen K, Hollatz D, Zielke S, Gisselmann G, Hatt H, Wetzel C. The TRPM8 ion channel comprises direct Gq protein-activating capacity. Pflugers Arch. 2012;463:779-97 pubmed publisher
    ..Investigating cascades stimulated downstream of the cold and menthol receptor TRPM8, we found evidence for both, functional and structural interaction of TRPM8 with G?q...
  87. Bidaux G, Beck B, Zholos A, Gordienko D, Lemonnier L, Flourakis M, et al. Regulation of activity of transient receptor potential melastatin 8 (TRPM8) channel by its short isoforms. J Biol Chem. 2012;287:2948-62 pubmed publisher
    ..This study focuses on the TRPM8, which functions as a cold receptor in sensory neurons but is also expressed in tissues not exposed to ambient ..
  88. Sabnis A, Reilly C, Veranth J, Yost G. Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures. Am J Physiol Lung Cell Mol Physiol. 2008;295:L194-200 pubmed publisher
    ..Transient receptor potential melastatin family member 8 (TRPM8) is a well-established cold- and menthol-sensing cation channel...
  89. Fernandez J, Skryma R, Bidaux G, Magleby K, Scholfield C, McGeown J, et al. Voltage- and cold-dependent gating of single TRPM8 ion channels. J Gen Physiol. 2011;137:173-95 pubmed publisher
    ..The TRPM8 cation channel has been extensively investigated as a major neuronal cold sensor but is also activated by voltage, ..
  90. Winchester W, Gore K, Glatt S, Petit W, Gardiner J, Conlon K, et al. Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. J Pharmacol Exp Ther. 2014;351:259-69 pubmed publisher
    The transient receptor potential (subfamily M, member 8; TRPM8) is a nonselective cation channel localized in primary sensory neurons, and is a candidate for cold thermosensing, mediation of cold pain, and bladder overactivity...
  91. Mergler S, Mertens C, Valtink M, Reinach P, Székely V, Slavi N, et al. Functional significance of thermosensitive transient receptor potential melastatin channel 8 (TRPM8) expression in immortalized human corneal endothelial cells. Exp Eye Res. 2013;116:337-49 pubmed publisher
    ..is modulated by temperature changes, we probed for thermosensitive transient receptor potential melastatin 8 (TRPM8) functional activity in immortalized human corneal endothelial cells (HCEC-12) and freshly isolated human corneal ..