TRPM6

Summary

Gene Symbol: TRPM6
Description: transient receptor potential cation channel subfamily M member 6
Alias: CHAK2, HMGX, HOMG, HOMG1, HSH, transient receptor potential cation channel subfamily M member 6, channel kinase 2, melastatin-related TRP cation channel 6
Species: human
Products:     TRPM6

Top Publications

  1. Riazanova L, Pavur K, Petrov A, Dorovkov M, Riazanov A. [Novel type of signaling molecules: protein kinases covalently linked to ion channels]. Mol Biol (Mosk). 2001;35:321-32 pubmed
    ..This suggests that melanoma and kidney alpha-kinases, which represent a novel type of signaling molecule, are involved in the regulation of Ca2+ influx in mammalian cells. ..
  2. Schlingmann K, Weber S, Peters M, Niemann Nejsum L, Vitzthum H, Klingel K, et al. Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat Genet. 2002;31:166-70 pubmed
    ..Using a positional candidate gene approach, we identified mutations in TRPM6 (also known as CHAK2), encoding TRPM6, in autosomal-recessive hypomagnesemia with secondary hypocalcemia (HSH, ..
  3. Li M, Jiang J, Yue L. Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. J Gen Physiol. 2006;127:525-37 pubmed
    b>TRPM6 and TRPM7 are two known channel kinases that play important roles in various physiological processes, including Mg2+ homeostasis. Mutations in TRPM6 cause hereditary hypomagnesemia and secondary hypocalcemia (HSH)...
  4. Thebault S, Alexander R, Tiel Groenestege W, Hoenderop J, Bindels R. EGF increases TRPM6 activity and surface expression. J Am Soc Nephrol. 2009;20:78-85 pubmed publisher
    ..that EGF increases the activity of the epithelial magnesium (Mg2+) channel transient receptor potential M6 (TRPM6)...
  5. Shuen A, Wong B, Wei C, Liu Z, Li M, Cole D. Genetic determinants of extracellular magnesium concentration: analysis of multiple candidate genes, and evidence for association with the estrogen receptor alpha (ESR1) locus. Clin Chim Acta. 2009;409:28-32 pubmed publisher
    ..Genomic DNA was amplified and SNPs in candidate genes (CASR, VDR, ESR1, CLDN16, EGF1, TRPM6) genotyped by routine methods...
  6. Lainez S, Schlingmann K, van der Wijst J, Dworniczak B, van Zeeland F, Konrad M, et al. New TRPM6 missense mutations linked to hypomagnesemia with secondary hypocalcemia. Eur J Hum Genet. 2014;22:497-504 pubmed publisher
    ..Mutations in the TRPM6 gene, encoding the epithelial Mg(2+) channel TRPM6 (transient receptor potential melastatin 6), have been proven ..
  7. Ryazanov A, Pavur K, Dorovkov M. Alpha-kinases: a new class of protein kinases with a novel catalytic domain. Curr Biol. 1999;9:R43-5 pubmed
  8. Walder R, Landau D, Meyer P, Shalev H, Tsolia M, Borochowitz Z, et al. Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. Nat Genet. 2002;31:171-4 pubmed
    ..Here we report that mutation of TRPM6 causes hypomagnesemia with secondary hypocalcemia and show that individuals carrying mutations in this gene have ..
  9. Voets T, Nilius B, Hoefs S, Van Der Kemp A, Droogmans G, Bindels R, et al. TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem. 2004;279:19-25 pubmed
    ..Recently, it was shown that patients with mutations in TRPM6, a member of the transient receptor potential family of cation channels, suffer from hypomagnesemia with secondary ..

More Information

Publications113 found, 100 shown here

  1. Schmitz C, Dorovkov M, Zhao X, Davenport B, Ryazanov A, Perraud A. The channel kinases TRPM6 and TRPM7 are functionally nonredundant. J Biol Chem. 2005;280:37763-71 pubmed
    TRPM7 and its closest homologue, TRPM6, are the only known fusions of an ion channel pore with a kinase domain. Deletion of TRPM7 in DT40 B-lymphocytes causes growth arrest, Mg(2+) deficiency, and cell death within 24-48 h...
  2. Clark K, Middelbeek J, Morrice N, Figdor C, Lasonder E, van Leeuwen F. Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7. PLoS ONE. 2008;3:e1876 pubmed publisher
    b>TRPM6 and TRPM7 are bifunctional proteins expressing a TRP channel fused to an atypical alpha-kinase domain...
  3. Chubanov V, Waldegger S, Mederos y Schnitzler M, Vitzthum H, Sassen M, Seyberth H, et al. Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. Proc Natl Acad Sci U S A. 2004;101:2894-9 pubmed
    Impaired magnesium reabsorption in patients with TRPM6 gene mutations stresses an important role of TRPM6 (melastatin-related TRP cation channel) in epithelial magnesium transport...
  4. Bödding M. TRPM6: A Janus-like protein. Handb Exp Pharmacol. 2007;:299-311 pubmed
    b>TRPM6 and TRPM7 proteins share similar molecular structures and biophysical properties. Both proteins are Mg(2+)- and Ca(2+)-permeable cation channels with the typical topology of six transmembrane domains...
  5. Cao G, Thebault S, van der Wijst J, van der Kemp A, Lasonder E, Bindels R, et al. RACK1 inhibits TRPM6 activity via phosphorylation of the fused alpha-kinase domain. Curr Biol. 2008;18:168-76 pubmed publisher
    ..Recently, the transient receptor potential melastatin 6 (TRPM6) was identified as the gatekeeper of active Mg(2+) transport and therefore plays a crucial role in the regulation ..
  6. Thebault S, Cao G, Venselaar H, Xi Q, Bindels R, Hoenderop J. Role of the alpha-kinase domain in transient receptor potential melastatin 6 channel and regulation by intracellular ATP. J Biol Chem. 2008;283:19999-20007 pubmed publisher
    Transient receptor potential melastatin 6 (TRPM6) plays an essential role in epithelial Mg(2+) transport. TRPM6 and its closest homologue, TRPM7, both combine a cation channel with an alpha-kinase domain...
  7. Zhang Z, Yu H, Huang J, Faouzi M, Schmitz C, Penner R, et al. The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels. J Biol Chem. 2014;289:5217-27 pubmed publisher
    The transient receptor potential melastatin member 7 (TRPM7) and member 6 (TRPM6) are divalent cation channel kinases essential for magnesium (Mg(2+)) homeostasis in vertebrates...
  8. Nair A, Hocher B, Verkaart S, van Zeeland F, Pfab T, Slowinski T, et al. Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy. Proc Natl Acad Sci U S A. 2012;109:11324-9 pubmed publisher
    ..Two single nucleotide polymorphisms (SNPs) in the epithelial magnesium channel TRPM6 (V(1393)I, K(1584)E) were predicted to confer susceptibility for DM2...
  9. Kolisek M, Sponder G, Pilchova I, Cibulka M, Tatarkova Z, Werner T, et al. Magnesium Extravaganza: A Critical Compendium of Current Research into Cellular Mg2+ Transporters Other than TRPM6/7. Rev Physiol Biochem Pharmacol. 2019;176:65-105 pubmed publisher
    ..of the molecular entities behind cellular Mg2+ homeostasis in mammalian/human cells other than TRPM6/7 chanzymes, which have been universally accepted as being unspecific cation channel kinases allowing the flux of ..
  10. Verschuren E, Hoenderop J, Peters D, Arjona F, Bindels R. Tubular flow activates magnesium transport in the distal convoluted tubule. FASEB J. 2019;33:5034-5044 pubmed publisher
    ..FSS did not affect the expression of magnesiotropic genes, including Cnnm2, Kcna1, Proegf, Trpm6, and Trpm7...
  11. Nie M, Bal M, Liu J, Yang Z, Rivera C, Wu X, et al. Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6). J Biol Chem. 2018;293:16488-16502 pubmed publisher
    ..in the distal convoluted tubule (DCT) via the apical magnesium channel transient receptor potential melastatin 6 (TRPM6). We observed decreased apical Trpm6 staining in the DCT of Umod -/- mice...
  12. Inoue R, Kurahara L, Hiraishi K. TRP channels in cardiac and intestinal fibrosis. Semin Cell Dev Biol. 2018;: pubmed publisher
    ..Available evidence suggests that several TRP channels such as TRPC3, TRPC6, TRPV1, TRPV3, TRPV4, TRPA1, TRPM6 and TRPM7 may play central roles in the progression and/or prevention of fibroproliferative disorders in vital ..
  13. Menè P, Punzo G, Pirozzi N. TRP channels as therapeutic targets in kidney disease and hypertension. Curr Top Med Chem. 2013;13:386-97 pubmed
    ..Similar to Ca2+, Mg2+ transcellular reabsorption occurs in the distal convoluted tubule via apical TRPM6/TRPM7 channels...
  14. Thongon N, Penguy J, Kulwong S, Khongmueang K, Thongma M. Omeprazole suppressed plasma magnesium level and duodenal magnesium absorption in male Sprague-Dawley rats. Pflugers Arch. 2016;468:1809-1821 pubmed
    ..for systemic Mg2+ deficiency, the expressions of duodenal transient receptor potential melastatin 6 (TRPM6), cyclin M4 (CNNM4), claudin (Cldn)-2, Cldn-7, Cldn-12, and Cldn-15 proteins were enhanced in omeprazole-treated ..
  15. Luongo F, Pietropaolo G, Gautier M, Dhennin Duthille I, Ouadid Ahidouch H, Wolf F, et al. TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon. Nutrients. 2018;10: pubmed publisher
    ..To explore the functional role of TRPM6 and TRPM7 in the colon, we used human colon cell lines that innately express both channels and analyzed the ..
  16. Lameris A, Nevalainen P, Reijnen D, Simons E, Eygensteyn J, Monnens L, et al. Segmental transport of Ca²⁺ and Mg²⁺ along the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2015;308:G206-16 pubmed publisher
    ..in the proximal intestinal segments, whereas Mg(2+) channel transient receptor potential melastatin subtype 6 (TRPM6) is expressed in the distal parts of the intestine...
  17. Just F, Oster M, Büsing K, Borgelt L, Murani E, Ponsuksili S, et al. Lowered dietary phosphorus affects intestinal and renal gene expression to maintain mineral homeostasis with immunomodulatory implications in weaned piglets. BMC Genomics. 2018;19:207 pubmed publisher
    ..The regulation of mineral homeostasis was reflected via altered mRNA abundances of CYP24A1, CYP27A1, TRPM6, SPP1, and VDR in jejunum and kidney...
  18. Li Y, Wang O, Quan T, Xia W, Jiang Y, Li M, et al. [A genomic study of adult-onset idiopathic hypoparathyroidism in Chinese by targeted next-generation sequencing]. Zhonghua Nei Ke Za Zhi. 2016;55:604-8 pubmed publisher
    ..to screen 11 related genes, including AIRE, AP2S1, CASR, CLDN16, FAM111A, GATA3, GCM2, PTH, TBCE, TBX1 and TRPM6. A novel homozygosis mutation of GCMB gene[c.130G>A (p...
  19. Chubanov V, Ferioli S, Wisnowsky A, Simmons D, Leitzinger C, Einer C, et al. Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. elife. 2016;5: pubmed publisher
    ..regulation of organismal Mg2+ balance during prenatal development and in adult mice by the ion channel TRPM6. We show that TRPM6 activity in the placenta and yolk sac is essential for embryonic development...
  20. Takashina Y, Manabe A, Hasegawa H, Matsunaga T, Endo S, Ikari A. Sodium Citrate Increases Expression and Flux of Mg2+ Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells. Nutrients. 2018;10: pubmed publisher
    ..the expression levels of Mg2+ transport carriers including transient receptor potential melastatin 6 (TRPM6) channel and cyclin M2 (CNNM2)...
  21. Nestler A, Rylander R, Kolisek M, Nielsen T, Ödman N, Vormann J, et al. Blood pressure in pregnancy and magnesium sensitive genes. Pregnancy Hypertens. 2014;4:41-5 pubmed publisher
    ..Urinary magnesium excretion and expression of MgSGs in leukocytes were determined. The expression of the gene TRPM6 was higher among pregnant women compared to non-pregnant controls at week 12...
  22. Choi H, Sun D, Jakobs T. Astrocytes in the optic nerve head express putative mechanosensitive channels. Mol Vis. 2015;21:749-66 pubmed
    ..Single-cell RT-PCR revealed that many TRP isoforms, TRPC1-2, TRPC6, TRPV2, TRPV4, TRPM2, TRPM4, TRPM6-7, TRPP1-2, and Piezo1-2, are expressed in astrocytes of the optic nerve head, and that most astrocytes express ..
  23. Won J, Kim J, Oh S. Molecular expression of Mg2+ regulator TRPM7 and CNNM4 in rat odontoblasts. Arch Oral Biol. 2018;96:182-188 pubmed publisher
    ..Expressions of TRPM6, TRPM7, CNNM1, CNNM2, CNNM3, CNNM4 were screened in acutely dissociated rat odontoblasts by single cell RT-PCR...
  24. Sánchez Rubio Ferrández J, Martínez Sesmero J. Pre-exposure prophylaxis for the prevention of HIV infection: a new prevention paradigm?. Farm Hosp. 2016;40:219-24 pubmed publisher
    ..este uso no está aprobado en nuestro país, varias guías recomiendan la PrEP como una opción de prevención en HSH adultos, hombres y mujeres heterosexuales, y los usuarios de drogas parenterales en riesgo de adquirir la infecció..
  25. Rodríguez Ramírez M, Rodriguez Moran M, Reyes Romero M, Guerrero Romero F. Effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1 in individuals newly diagnosed of pre-hypertension. A randomized, double-blind, placebo-controlled trial. Magnes Res. 2017;30:80-87 pubmed publisher
    ..With this regard, we evaluate the effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1, in individuals with incident pre-hypertension (preHTN)...
  26. Hess M, de Baaij J, Gommers L, Hoenderop J, Bindels R. Dietary Inulin Fibers Prevent Proton-Pump Inhibitor (PPI)-Induced Hypocalcemia in Mice. PLoS ONE. 2015;10:e0138881 pubmed publisher
    ..Additionally, intestinal and renal mRNA levels of the Trpm6 gene were reduced after inulin intake...
  27. Pasha Hosseinbor A, Chung M, Wu Y, Bendlin B, Alexander A. A 4D hyperspherical interpretation of q-space. Med Image Anal. 2015;21:15-28 pubmed publisher
    ..by projecting it onto a hypersphere and subsequently modeling the q-space signal via 4D hyperspherical harmonics (HSH)...
  28. Geng Y, Feng B. Mesendogen, a novel inhibitor of TRPM6, promotes mesoderm and definitive endoderm differentiation of human embryonic stem cells through alteration of magnesium homeostasis. Heliyon. 2015;1:e00046 pubmed
    ..hetero-tetrameric channel complexes formed by transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) (collectively referred to as TRPM6/TRPM7 channels in this study) are the major regulators of ..
  29. Kladnitsky O, Rozenfeld J, Azulay Debby H, Efrati E, Zelikovic I. The claudin-16 channel gene is transcriptionally inhibited by 1,25-dihydroxyvitamin D. Exp Physiol. 2015;100:79-94 pubmed publisher
    ..treated HEK 293 cells showed similar changes in claudin-16 mRNA, but 1,25(OH)2 VitD did not alter mRNA of the TRPM6 Mg(2+) channel. A luciferase reporter vector containing 2...
  30. Cuffe J, Steane S, Moritz K, Paravicini T. Differential mRNA expression and glucocorticoid-mediated regulation of TRPM6 and TRPM7 in the heart and kidney throughout murine pregnancy and development. PLoS ONE. 2015;10:e0117978 pubmed publisher
    The transient receptor potential (TRP) channels TRPM6 and TRPM7 are critically involved in maintaining whole body and cellular Mg2+ homeostasis and ensuring the normal function of organs such as the heart and kidney...
  31. Rapisarda F, Portale G, Ferrario S, Sessa C, Aliotta R, Zanoli L, et al. [Magnesium, calcium and potassium: "no one was born alone"]. G Ital Nefrol. 2016;33: pubmed
    ..with renal transplantation in therapy with calcineurin inhibitors ICN, due to the effects of such drugs on the TRPM6 transporter present in the kidney distal convoluted tubule...
  32. Rosendahl J, Braun H, Schrapers K, Martens H, Stumpff F. Evidence for the functional involvement of members of the TRP channel family in the uptake of Na(+) and NH4 (+) by the ruminal epithelium. Pflugers Arch. 2016;468:1333-52 pubmed publisher
    ..On the level of messenger RNA (mRNA), ovine and bovine ruminal epithelium expressed TRPA1, TRPV3, TRPV4, TRPM6, and TRPM7, with any expression of TRPV6 marginal. No bands were detected for TRPV1, TRPV5, or TRPM8...
  33. Miyata T, Beppu T, Kuramoto K, Nakagawa S, Imai K, Hashimoto D, et al. Hepatic sclerosed hemangioma with special attention to diffusion-weighted magnetic resonance imaging. Surg Case Rep. 2018;4:3 pubmed publisher
    A hepatic sclerosed hemangioma (HSH) is a very rare benign liver tumor...
  34. Fredin S, Akins M, Ferraretto L, Shaver R. Effects of corn-based diet starch content and neutral detergent fiber source on lactation performance, digestibility, and bacterial protein flow in dairy cows. J Dairy Sci. 2015;98:554-65 pubmed publisher
    ..Treatment diets were high corn grain (HCG; 38% corn silage, 19% dry ground corn, and 4% soy hulls), high soy hulls (HSH; 38% corn silage, 11% dry ground corn, and 13% soy hulls), high corn silage (HCS; 50% corn silage, 6% dry ground ..
  35. Isman E, Aras M, Cengiz B, Bayraktar R, Yolcu U, Topcuoglu T, et al. Effects of laser irradiation at different wavelengths (660, 810, 980, and 1064 nm) on transient receptor potential melastatin channels in an animal model of wound healing. Lasers Med Sci. 2015;30:1489-95 pubmed publisher
    ..05). In 980-nm group, TRPM4, TRPM6, and TRPM7 were significantly higher than in the control group (p < 0.005)...
  36. Suzuki Y, Watanabe M, Saito C, Tominaga M. Expression of the TRPM6 in mouse placental trophoblasts; potential role in maternal-fetal calcium transport. J Physiol Sci. 2017;67:151-162 pubmed publisher
    ..In an attempt to clarify the molecular basis of Ca2+ entry for this transport, we identified TRPM6 as a candidate for apical Ca2+ entry pathway...
  37. Bilgin Y, Hot S, Barlas Ä, Akan A, Eryavuz Y. Short- and long-term results of harmonic scalpel hemorrhoidectomy versus stapler hemorrhoidopexy in treatment of hemorrhoidal disease. Asian J Surg. 2015;38:214-9 pubmed publisher
    ..randomized study, our aim is to compare the short- and long-term results of harmonic scalpel hemorrhoidectomy (HSH) and stapler hemorrhoidopexy (SH) methods in the surgical treatment of Grade III and Grade IV hemorrhoidal disease...
  38. Blanchard M, de Baaij J, Verkaart S, Lameris A, Basmadjian C, Zhao Q, et al. Flavaglines Stimulate Transient Receptor Potential Melastatin Type 6 (TRPM6) Channel Activity. PLoS ONE. 2015;10:e0119028 pubmed publisher
    ..entry of Mg2+ in (re)absorbing epithelial cells is mediated by the transient receptor potential melastatin type 6 (TRPM6) ion channel. Here, flavaglines are described as a novel class of stimulatory compounds for TRPM6 activity...
  39. Redondo Domínguez D, Picazo L, Docavo Barrenechea Moxo M, González del Castillo J. Chemsex: are we prepared?. Adicciones. 2018;30:158-159 pubmed publisher
    ..prevalencia del consumo de drogas en el contexto de la actividad sexual en hombres que mantienen sexo con hombres (HSH) en Europa Occidental (Fernández-Dávila et al,. 2016)...
  40. Astor M, Løvås K, Wolff A, Nedrebø B, Bratland E, Steen Johnsen J, et al. Hypomagnesemia and functional hypoparathyroidism due to novel mutations in the Mg-channel TRPM6. Endocr Connect. 2015;4:215-22 pubmed publisher
    ..Homozygous mutations in the magnesium transporter gene transient receptor potential cation channel member 6 (TRPM6) cause the disease. HSH can be misdiagnosed as primary hypoparathyroidism...
  41. Vanka R, Kuppusamy G, Praveen Kumar S, Baruah U, Karri V, Pandey V, et al. Ameliorating the in vivo antimalarial efficacy of artemether using nanostructured lipid carriers. J Microencapsul. 2018;35:121-136 pubmed publisher
    ..NLCs of ARM were prepared by a combination of high speed homogenisation (HSH) and probe sonication techniques...
  42. Azim M, Mehnaz A, Ahmed J, Mujtaba G. Exome sequencing identifies a novel frameshift variant causing hypomagnesemia with secondary hypocalcemia. CEN Case Rep. 2019;8:42-47 pubmed publisher
    ..Mutations in the TRPM6 gene, encoding the epithelial Mg2+ channel TRPM6, have been proven to be the molecular cause of this ..
  43. Rodríguez E, Bach A, Devant M, Aris A. Is calcitonin an active hormone in the onset and prevention of hypocalcemia in dairy cattle?. J Dairy Sci. 2016;99:3023-3030 pubmed publisher
    ..5 and 8.5mg/dL, or as high subclinical hypocalcemia (HSH) when blood Ca concentrations were between 6.0 and 7.6 mg/dL...
  44. Kim J, Kim D, Lee Y, Suh K. Long-term follow-up of Starion™ versus Harmonic Scalpel™ hemorrhoidectomy for grade III and IV hemorrhoids. Asian J Surg. 2019;42:367-372 pubmed publisher
    ..114 patients in the SH group (Starion™ hemorrhoidectomy) and 107 patients in the HSH group (Harmonic Scalpel™) were contacted for cumulative inspection 1 week, 4 weeks, and 3 years post-operatively ..
  45. Kampik N, Gehring N, Schnitzbauer U, Hennings J, Hübner C, Wagner C. The murine Cl⁻/HCO⁻₃ exchanger Ae3 (Slc4a3) is not required for acid-base balance but is involved in magnesium handling by the kidney. Cell Physiol Biochem. 2014;34:1566-77 pubmed publisher
    ..high and low magnesium diets and found no differences in renal magnesium excretion but elevated expression of the Trpm6 magnesium channel in Ae3 KO mice. In conclusion, Ae3 is expressed in murine kidney at very low levels...
  46. Takayanagi K, Shimizu T, Tayama Y, Ikari A, Anzai N, Iwashita T, et al. Downregulation of transient receptor potential M6 channels as a cause of hypermagnesiuric hypomagnesemia in obese type 2 diabetic rats. Am J Physiol Renal Physiol. 2015;308:F1386-97 pubmed publisher
    ..The results of the semiquantitative analysis of immunohistochemistry were consistent with these findings (TRPM6: 0.49 ± 0.04% in 16-wk-old LETO rats, 0.10 ± 0.01% in 16-wk-old OLETF rats, 0.52 ± 0...
  47. de Baaij J, Arjona F, van den Brand M, Lavrijsen M, Lameris A, Bindels R, et al. Identification of SLC41A3 as a novel player in magnesium homeostasis. Sci Rep. 2016;6:28565 pubmed publisher
    ..mice, although Slc41a3(-/-) animals exhibited increased intestinal mRNA expression of Mg(2+) transporters Trpm6 and Slc41a1. Remarkably, some of the Slc41a3(-/-) mice developed severe unilateral hydronephrosis...
  48. Coulter M, Colvin C, Korf B, Messiaen L, Tuanama B, Crowley M, et al. Hypomagnesemia due to two novel TRPM6 mutations. J Pediatr Endocrinol Metab. 2015;28:1373-8 pubmed publisher
    ..As his clinical presentation suggested primary renal magnesium wastage, TRPM6 gene mutations were suspected; subsequent genetic testing revealed the child to be compound heterozygous for TRPM6 ..
  49. Keller I, Flöter C, Ragoschke Schumm A, Faßbender K. [The Homburg clinic for nervous diseases in the National Socialist Era. Special features in the Saarland border region]. Nervenarzt. 2016;87:195-202 pubmed publisher
    ..The analysis is based on medical records of the Homburg State Hospital's (HSH) clinic for nervous diseases from 1929 to 1945 (n =7,816) found in the Saarland University Medical Centre...
  50. Jansen C, Sahni J, Suzuki S, Horgen F, Penner R, Fleig A. The coiled-coil domain of zebrafish TRPM7 regulates Mg·nucleotide sensitivity. Sci Rep. 2016;6:33459 pubmed publisher
    ..This is reminiscent of the pharmacological profile of human TRPM6, the sister channel kinase of TRPM7...
  51. Lamorte A, Boero E, Crida P, Conteh A, Foletti M, Narcisi P. The Sierra Leone Ultrasound Rainbow4Africa Project (SLURP): an observational study of ultrasound effectiveness in developing countries. Crit Ultrasound J. 2016;8:14 pubmed
    ..This is a prospective, observational study on outpatients presenting at the HSH. We enrolled continually for 1 month 105 patients asked for ultrasound examination by the caring physician that ..
  52. Lee C, Ng H, Lee Y, Lai L, Lien Y. The role of calbindin-D28k on renal calcium and magnesium handling during treatment with loop and thiazide diuretics. Am J Physiol Renal Physiol. 2016;310:F230-6 pubmed publisher
    ..Urine Mg excretion was increased and transient receptor potential subfamily M, member 6 (TRPM6) was upregulated by both CTZ and FSM in WT and KO mice...
  53. Stone Brown K, Naji M, Francioni A, Myers K, Samarendra H, Mushtaq Chaudhry H, et al. Psychotropic prescribing in seriously violent men with schizophrenia or personality disorder in a UK high security hospital. CNS Spectr. 2016;21:60-9 pubmed publisher
    To analyze antipsychotic prescribing patterns in a UK high security hospital (HSH) that treats seriously violent men with either schizophrenia or personality disorder and examine how different groups consented to treatment and ..
  54. de Baaij J, Kompatscher A, Viering D, Bos C, Bindels R, Hoenderop J. P2X6 Knockout Mice Exhibit Normal Electrolyte Homeostasis. PLoS ONE. 2016;11:e0156803 pubmed publisher
    ..changes in renal expression levels of other P2x subunits and electrolyte transporters, including P2x1-5, P2x7, Trpm6, Ncc, Egf, Cldn16, Scnn1, Slc12a3, Slc41a1, Slc41a3, Cnnm2, Kcnj10 and Fxyd2...
  55. Bijsmans I, Milona A, Ijssennagger N, Willemsen E, Ramos Pittol J, Jonker J, et al. Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology. Biochim Biophys Acta Mol Basis Dis. 2017;1863:687-700 pubmed publisher
    ..Finally, using organoids we identify Trpm6, Slc26a3, Ang1, and Rnase4, as novel Fxr target genes...
  56. Kieboom B, Ligthart S, Dehghan A, Kurstjens S, de Baaij J, Franco O, et al. Serum magnesium and the risk of prediabetes: a population-based cohort study. Diabetologia. 2017;60:843-853 pubmed publisher
    ..12 [95% CI 1.01, 1.25]). Genetic variation in CLDN19, CNNM2, FXYD2, SLC41A2, and TRPM6 significantly influenced diabetes risk (p < 0...
  57. Hua X, Xu S, Wang M, Chen Y, Yang H, Yang R. Effects of high-speed homogenization and high-pressure homogenization on structure of tomato residue fibers. Food Chem. 2017;232:443-449 pubmed publisher
    Tomato residue fibers obtained after derosination and deproteinization were processed by high-speed homogenization (HSH) and high-pressure homogenization (HPH), and their effects on fiber structure was investigated, respectively...
  58. Beggs M, Appel I, Svenningsen P, Skjødt K, Alexander R, Dimke H. Expression of transcellular and paracellular calcium and magnesium transport proteins in renal and intestinal epithelia during lactation. Am J Physiol Renal Physiol. 2017;313:F629-F640 pubmed publisher
    ..Colonic Trpm6 expression increased during lactation, while renal Trpm6 remained unaltered...
  59. van Angelen A, van der Kemp A, Hoenderop J, Bindels R. Increased expression of renal TRPM6 compensates for Mg(2+) wasting during furosemide treatment. Clin Kidney J. 2012;5:535-44 pubmed publisher
    ..Next, renal mRNA levels of the epithelial Mg(2+) channel (TRPM6), the Na(+), Cl(-) cotransporter (NCC), the epithelial Ca(2+) channel (TRPV5), the cytosolic Ca(2+)-binding ..
  60. Blanchard M, Kittikulsuth W, Nair A, de Baaij J, Latta F, Genzen J, et al. Regulation of Mg2+ Reabsorption and Transient Receptor Potential Melastatin Type 6 Activity by cAMP Signaling. J Am Soc Nephrol. 2016;27:804-13 pubmed publisher
    The transient receptor potential melastatin type 6 (TRPM6) epithelial Mg(2+) channels participate in transcellular Mg(2+) transport in the kidney and intestine...
  61. Inose R, Takahashi K, Nishikawa T, Nagayama K. [Analysis of Factors Influencing the Development of Hypomagnesemia in Patients Receiving Cetuximab Therapy for Head and Neck Cancer]. Yakugaku Zasshi. 2015;135:1403-7 pubmed publisher
    ..034). Magnesium is reabsorbed by transient receptor potential subfamily melastatin 6 (TRPM6) in the distal convoluted tubule...
  62. Cai N, Bai Z, Nanda V, Runnels L. Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases. Sci Rep. 2017;7:42739 pubmed publisher
    TRPM7 and TRPM6 were the first identified bifunctional channels to contain their own kinase domains, but how these channel-kinases are regulated is poorly understood...
  63. Song Y, Hsu Y, Niu T, Manson J, Buring J, Liu S. Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women. BMC Med Genet. 2009;10:4 pubmed publisher
    Ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7) play a central role in magnesium homeostasis, which is critical for maintaining glucose and insulin metabolism...
  64. Cao G, van der Wijst J, van der Kemp A, van Zeeland F, Bindels R, Hoenderop J. Regulation of the epithelial Mg2+ channel TRPM6 by estrogen and the associated repressor protein of estrogen receptor activity (REA). J Biol Chem. 2009;284:14788-95 pubmed publisher
    ..The Transient Receptor Potential Melastatin 6 (TRPM6) functions as the gatekeeper of transepithelial Mg(2+) transport...
  65. Meyer T, Verwoert G, Hwang S, Glazer N, Smith A, van Rooij F, et al. Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. PLoS Genet. 2010;6: pubmed publisher
    ..The association of common variants at six genomic regions (in or near MUC1, ATP2B1, DCDC5, TRPM6, SHROOM3, and MDS1) with serum magnesium levels was genome-wide significant when meta-analyzed with the ..
  66. Romero J, Castonguay A, Barton N, Germer S, Martin M, Zee R. Gene variation of the transient receptor potential cation channel, subfamily M, members 6 (TRPM6) and 7 (TRPM7), and type 2 diabetes mellitus: a case-control study. Transl Res. 2010;156:235-41 pubmed publisher
    Transient receptor potential cation channel, subfamily M, members 6 (TRPM6) and 7 (TRPM7), have been implicated in inflammatory disorders including diabetes, a major source of morbidity and mortality in developing and Western society...
  67. Castiglioni S, Cazzaniga A, Trapani V, Cappadone C, Farruggia G, Merolle L, et al. Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin. Sci Rep. 2015;5:16538 pubmed publisher
    ..Accordingly, resistant cells express lower amounts of the TRPM6 and 7, both involved in magnesium transport...
  68. Chubanov V, Gudermann T, Schlingmann K. Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. Pflugers Arch. 2005;451:228-34 pubmed
    ..and renal magnesium conservation, have identified "transient receptor potential (melastatin) 6" (TRPM6) as the first component involved directly in epithelial magnesium reabsorption...
  69. Flach C, Qadri F, Bhuiyan T, Alam N, Jennische E, Holmgren J, et al. Differential expression of intestinal membrane transporters in cholera patients. FEBS Lett. 2007;581:3183-8 pubmed
    ..Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, ..
  70. van der Wijst J, Blanchard M, Woodroof H, MacArtney T, Gourlay R, Hoenderop J, et al. Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction. Biochem J. 2014;460:165-75 pubmed publisher
    Mutations in the gene that encodes the atypical channel-kinase TRPM6 (transient receptor potential melastatin 6) cause HSH (hypomagnesaemia with secondary hypocalcaemia), a disorder characterized by defective intestinal Mg2+ transport ..
  71. Brandao K, Deason Towne F, Zhao X, Perraud A, Schmitz C. TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions. Cell Mol Life Sci. 2014;71:4853-67 pubmed publisher
    The channel kinases TRPM6 and TRPM7 are both members of the melastatin-related transient receptor potential (TRPM) subfamily of ion channels and the only known fusions of an ion channel pore with a kinase domain...
  72. Krapivinsky G, Krapivinsky L, Renthal N, Santa Cruz A, Manasian Y, Clapham D. Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression. Proc Natl Acad Sci U S A. 2017;114:E7092-E7100 pubmed publisher
    b>TRPM6 and TRPM7 are members of the melastatin-related transient receptor potential (TRPM) subfamily of ion channels. Deletion of either gene in mice is embryonically lethal...
  73. Touyz R. Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension. Am J Physiol Heart Circ Physiol. 2008;294:H1103-18 pubmed publisher
    ..receptor potential melastatin (TRPM) cation channel family have now been identified as magnesium transporters, TRPM6 and TRPM7...
  74. Wolf F, Trapani V. Magnesium and its transporters in cancer: a novel paradigm in tumour development. Clin Sci (Lond). 2012;123:417-27 pubmed publisher
  75. Düzen I, Yavuz F, Vuruşkan E, Saraçoğlu E, Poyraz F, Goksuluk H, et al. Leukocyte TRP channel gene expressions in patients with non-valvular atrial fibrillation. Sci Rep. 2017;7:9272 pubmed publisher
    ..marked increases in MCOLN1 (TRPML1), MCOLN2 (TRPML2), MCOLN3 (TRPML3), TRPA1, TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8, TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, TRPC7, TRPV1, TRPV2, TRPV3, TRPV4, TRPV5, TRPV6, and PKD2 ..
  76. Walder R, Shalev H, Brennan T, Carmi R, Elbedour K, Scott D, et al. Familial hypomagnesemia maps to chromosome 9q, not to the X chromosome: genetic linkage mapping and analysis of a balanced translocation breakpoint. Hum Mol Genet. 1997;6:1491-7 pubmed
    Familial hypomagnesemia with secondary hypocalcemia (HSH) (MIM 307600) was studied in three inbred Bedouin kindreds from Israel...
  77. Quamme G. Recent developments in intestinal magnesium absorption. Curr Opin Gastroenterol. 2008;24:230-5 pubmed publisher
    ..The predominant Mg transporters include TRPM6 and TRPM7, members of the transient receptor potential melastatin family of cation channels...
  78. Guran T, Akcay T, Bereket A, Atay Z, Turan S, Haisch L, et al. Clinical and molecular characterization of Turkish patients with familial hypomagnesaemia: novel mutations in TRPM6 and CLDN16 genes. Nephrol Dial Transplant. 2012;27:667-73 pubmed publisher
    ..Genetic studies revealed familial hypomagnesaemia with secondary hypocalcaemia (HSH) due to a TRPM6 mutation in six patients and familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC) due to a ..
  79. Xu L, Maalouf N. Effect of acute hyperinsulinemia on magnesium homeostasis in humans. Diabetes Metab Res Rev. 2017;33: pubmed publisher
    ..shift of magnesium from plasma into red blood cells and platelets, and in vitro, it stimulates the activity of the TRPM6 channel, a key regulator of renal magnesium reabsorption...
  80. Chubanov V, Mittermeier L, Gudermann T. Role of kinase-coupled TRP channels in mineral homeostasis. Pharmacol Ther. 2018;184:159-176 pubmed publisher
    Transient receptor potential (TRP) proteins TRPM6 and TRPM7 are α-kinase-coupled divalent cation-selective channels activated upon a reduction of cytosolic levels of Mg2+ and Mg·ATP...
  81. Dietrich A, Chubanov V, Gudermann T. Renal TRPathies. J Am Soc Nephrol. 2010;21:736-44 pubmed publisher
    ..This review focuses on two TRP members--TRPC6 and TRPM6--and their functions in the kidney...
  82. Ikari A, Sanada A, Sawada H, Okude C, Tonegawa C, Sugatani J. Decrease in transient receptor potential melastatin 6 mRNA stability caused by rapamycin in renal tubular epithelial cells. Biochim Biophys Acta. 2011;1808:1502-8 pubmed publisher
    ..Here, we investigated the effect of rapamycin on the expression of transient receptor potential melastatin 6 (TRPM6), a Mg2+ channel...
  83. van der Wijst J, Bindels R, Hoenderop J. Mg2+ homeostasis: the balancing act of TRPM6. Curr Opin Nephrol Hypertens. 2014;23:361-9 pubmed publisher
    ..This review aims to give an up-to-date overview of transient receptor potential melastatin 6 (TRPM6) regulation and its role in the maintenance of Mg homeostasis...
  84. Zhang Z, Faouzi M, Huang J, Geerts D, Yu H, Fleig A, et al. N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation. Oncotarget. 2014;5:7625-34 pubmed
    ..The channel kinases TRPM6 and TRPM7 are gatekeepers of human Ca2+/Mg2+ metabolism...
  85. Cabezas Bratesco D, Brauchi S, González Teuber V, Steinberg X, Valencia I, Colenso C. The Different Roles of The Channel-Kinases TRPM6 and TRPM7. Curr Med Chem. 2015;22:2943-53 pubmed
    Melastatin-related Transient Receptor Potential 6 and 7 (TRPM6 and TRPM7) are cation channels with the almost unique trait of each possessing a kinase domain in its C terminus...
  86. Zhang Y, Mathewson P, Zhang Q, Porter W, Ran J. An ecophysiological perspective on likely giant panda habitat responses to climate change. Glob Chang Biol. 2017;: pubmed publisher
    ..We combined SAA with bamboo forest distribution to yield highly suitable habitat (HSH) and seasonal suitable habitat (SSH), and their temporal dynamics under climate change were predicted...
  87. Altıncık A, Schlingmann K, Tosun M. A Novel Homozygous Mutation in the Transient Receptor Potential Melastatin 6 Gene: A Case Report. J Clin Res Pediatr Endocrinol. 2016;8:101-4 pubmed publisher
    ..HSH) is a rare autosomal recessive disease caused by mutations in the transient receptor potential melastatin 6 (TRPM6) gene...
  88. Furukawa C, Fujii N, Manabe A, Matsunaga T, Endo S, Hasegawa H, et al. Up-Regulation of Transient Receptor Potential Melastatin 6 Channel Expression by Tumor Necrosis Factor-? in the Presence of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor. J Cell Physiol. 2017;232:2841-2850 pubmed publisher
    ..The transient receptor potential melastatin 6 (TRPM6) channel is involved in the reabsorption of Mg2+ in the renal tubule...
  89. Corre T, Arjona F, Hayward C, Youhanna S, de Baaij J, Belge H, et al. Genome-Wide Meta-Analysis Unravels Interactions between Magnesium Homeostasis and Metabolic Phenotypes. J Am Soc Nephrol. 2018;29:335-348 pubmed publisher
    ..4×10-13) near TRPM6, which encodes an epithelial Mg2+ channel, and rs35929 (P=2...
  90. Tang M, Chen X, Sun Z, Xie Y, Schaefer H. The Hydrogen Abstraction Reaction H2S + OH ? H2O + SH: Convergent Quantum Mechanical Predictions. J Phys Chem A. 2017;: pubmed publisher
    ..For the reactant (entrance) complex, the CCSD(T) method predicts a HSH···OH hydrogen-bonded structure to be lowest-lying, and the other lower-lying isomers, including the two-center ..
  91. Saade S, Kutlu B, Draba V, Forster K, Schumann E, Tester M, et al. A donor-specific QTL, exhibiting allelic variation for leaf sheath hairiness in a nested association mapping population, is located on barley chromosome 4H. PLoS ONE. 2017;12:e0189446 pubmed publisher
    ..We detected the major hairy leaf sheath locus Hs (syn. Hsh) on chromosome 4H (111.3 cM) with high precision...
  92. Ikari A, Sanada A, Okude C, Sawada H, Yamazaki Y, Sugatani J, et al. Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells. J Cell Physiol. 2010;222:481-7 pubmed publisher
    Transient receptor potential melastatin 6 (TRPM6) channel is involved in the reabsorption of magnesium in the kidney. We recently found that TRPM6 expression is up-regulated by EGF, but the regulatory mechanism has not been clear...