TRPC6

Summary

Gene Symbol: TRPC6
Description: transient receptor potential cation channel subfamily C member 6
Alias: FSGS2, TRP6, short transient receptor potential channel 6, TRP-6, focal segmental glomerulosclerosis 2, transient receptor protein 6
Species: human
Products:     TRPC6

Top Publications

  1. El Boustany C, Bidaux G, Enfissi A, Delcourt P, Prevarskaya N, Capiod T. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation. Hepatology. 2008;47:2068-77 pubmed publisher
    ..Huh-7 and HepG2 cells express transient receptor potential canonical 1 (TRPC1) and TRPC6, as well as STIM1 and Orai1, and these 4 channels are the most likely candidates to account for the SOCE in these ..
  2. Reiser J, Polu K, Möller C, Kenlan P, Altintas M, Wei C, et al. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet. 2005;37:739-44 pubmed
    ..Here, we show that the canonical transient receptor potential 6 (TRPC6) ion channel is expressed in podocytes and is a component of the glomerular slit diaphragm...
  3. Heeringa S, Möller C, Du J, Yue L, Hinkes B, Chernin G, et al. A novel TRPC6 mutation that causes childhood FSGS. PLoS ONE. 2009;4:e7771 pubmed publisher
    b>TRPC6, encoding a member of the transient receptor potential (TRP) superfamily of ion channels, is a calcium-permeable cation channel, which mediates capacitive calcium entry into the cell...
  4. Gigante M, Caridi G, Montemurno E, Soccio M, D Apolito M, Cerullo G, et al. TRPC6 mutations in children with steroid-resistant nephrotic syndrome and atypical phenotype. Clin J Am Soc Nephrol. 2011;6:1626-34 pubmed publisher
    Mutations in the TRPC6 gene have been recently identified as the cause of late-onset autosomal-dominant focal segmental glomerulosclerosis (FSGS)...
  5. Boulay G, Brown D, Qin N, Jiang M, Dietrich A, Zhu M, et al. Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry. Proc Natl Acad Sci U S A. 1999;96:14955-60 pubmed
    ..IP3Rs, therefore, have the dual role of releasing Ca(2+) from stores and activating Ca(2+) influx in response to either increasing IP3 or decreasing luminal Ca(2+). ..
  6. Santin S, Ars E, Rossetti S, Salido E, Silva I, García Maset R, et al. TRPC6 mutational analysis in a large cohort of patients with focal segmental glomerulosclerosis. Nephrol Dial Transplant. 2009;24:3089-96 pubmed publisher
    Mutations in the TRPC6 gene have been reported in six families with adult-onset (17-57 years) autosomal dominant focal segmental glomerulosclerosis (FSGS)...
  7. Cai R, Ding X, Zhou K, Shi Y, Ge R, Ren G, et al. Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells. Int J Cancer. 2009;125:2281-7 pubmed publisher
    ..Through a phospholipase C (PLC)-dependent mechanism TRPC6, a member of TRPC subfamily, can be activated by receptor tyrosine kinases (RTK) or G protein-coupled receptors (..
  8. Cayouette S, Lussier M, Mathieu E, Bousquet S, Boulay G. Exocytotic insertion of TRPC6 channel into the plasma membrane upon Gq protein-coupled receptor activation. J Biol Chem. 2004;279:7241-6 pubmed
    ..To investigate the possible involvement of exocytosis in TRPC6 activation, we evaluated the location of TRPC6 at the plasma membrane by biotinylation labeling of cell surface ..
  9. Jardin I, Redondo P, Salido G, Rosado J. Phosphatidylinositol 4,5-bisphosphate enhances store-operated calcium entry through hTRPC6 channel in human platelets. Biochim Biophys Acta. 2008;1783:84-97 pubmed
    ..In summary, hTRPC6 plays a role both in store-operated and in non-capacitative Ca2+ entry. PIP2 enhances store-operated Ca2+ entry in human platelets, most probably by stimulation of hTRPC6 channels. ..

More Information

Publications82

  1. Yue D, Wang Y, Xiao J, Wang P, Ren C. Expression of TRPC6 in benign and malignant human prostate tissues. Asian J Androl. 2009;11:541-7 pubmed publisher
    We investigated the expression of transient receptor potential canonical 6 (TRPC6) protein in benign and malignant human prostate tissues and in prostate cancer cell lines and the association with the stage, grade and androgen ..
  2. Lussier M, Cayouette S, Lepage P, Bernier C, Francoeur N, St Hilaire M, et al. MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. J Biol Chem. 2005;280:19393-400 pubmed
    ..Using a yeast two-hybrid interaction assay, we found that the second ankyrin-like repeat domain of TRPC6 interacted with MxA, a member of the dynamin superfamily...
  3. Bandyopadhyay B, Swaim W, Liu X, Redman R, Patterson R, Ambudkar I. Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx. J Biol Chem. 2005;280:12908-16 pubmed
    ..In contrast, TRPC1 was localized basolaterally, whereas TRPC6 was detected in both locations...
  4. Estacion M, Li S, Sinkins W, Gosling M, Bahra P, Poll C, et al. Activation of human TRPC6 channels by receptor stimulation. J Biol Chem. 2004;279:22047-56 pubmed
    The human TRPC6 channel was expressed in human embryonic kidney (HEK) cells, and activity was monitored using the giga-seal technique...
  5. Bousquet S, Monet M, Boulay G. Protein kinase C-dependent phosphorylation of transient receptor potential canonical 6 (TRPC6) on serine 448 causes channel inhibition. J Biol Chem. 2010;285:40534-43 pubmed publisher
    b>TRPC6 is a cation channel in the plasma membrane that plays a role in Ca(2+) entry following the stimulation of a G(q)-protein coupled or tyrosine kinase receptor...
  6. Monet M, Francoeur N, Boulay G. Involvement of phosphoinositide 3-kinase and PTEN protein in mechanism of activation of TRPC6 protein in vascular smooth muscle cells. J Biol Chem. 2012;287:17672-81 pubmed publisher
    b>TRPC6 is a cation channel in the plasma membrane that plays a role in Ca(2+) entry after the stimulation of a G(q)-protein-coupled or tyrosine-kinase receptor...
  7. Hofmann T, Schaefer M, Schultz G, Gudermann T. Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci U S A. 2002;99:7461-6 pubmed
    ..g., TRPC4/5 or TRPC3/6/7. The principles of TRPC channel formation offer the conceptual framework to assess the physiological role of distinct TRPC proteins in living cells. ..
  8. Tang J, Lin Y, Zhang Z, Tikunova S, Birnbaumer L, Zhu M. Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. J Biol Chem. 2001;276:21303-10 pubmed
    ..with calmodulin (CaM) in a Ca(2+)-dependent manner with affinities ranging from 10 nm for Trp2 to 290 nm for Trp6. In addition, other binding sites for CaM and IP(3)Rs are present in the alpha but not the beta isoform of Trp4...
  9. Ding X, He Z, Zhou K, Cheng J, Yao H, Lu D, et al. Essential role of TRPC6 channels in G2/M phase transition and development of human glioma. J Natl Cancer Inst. 2010;102:1052-68 pubmed publisher
    ..In this study, we investigated the role of TRPC6 in cell cycle progression and in the development of human glioma...
  10. Chigurupati S, Venkataraman R, Barrera D, Naganathan A, Madan M, Paul L, et al. Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness. Cancer Res. 2010;70:418-27 pubmed publisher
    ..that hypoxia increases Notch1 activation, which in turn induces the expression of transient receptor potential 6 (TRPC6) in primary samples and cell lines derived from GBM...
  11. Inoue R, Jensen L, Jian Z, Shi J, Hai L, Lurie A, et al. Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/diacylglycerol and phospholipase A2/omega-hydroxylase/20-HETE pathways. Circ Res. 2009;104:1399-409 pubmed publisher
    b>TRPC6 is a non-voltage-gated Ca(2+) entry/depolarization channel associated with vascular tone regulation and remodeling...
  12. Zhu B, Chen N, Wang Z, Pan X, Ren H, Zhang W, et al. Identification and functional analysis of a novel TRPC6 mutation associated with late onset familial focal segmental glomerulosclerosis in Chinese patients. Mutat Res. 2009;664:84-90 pubmed publisher
    Mutations in the TRPC6 gene are responsible for a late onset form of familial focal segmental glomerulosclerosis (FSGS). However, the role of TRPC6 variation in Chinese patients with late onset familial FSGS remains unclear...
  13. Kim E, Alvarez Baron C, Dryer S. Canonical transient receptor potential channel (TRPC)3 and TRPC6 associate with large-conductance Ca2+-activated K+ (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes. Mol Pharmacol. 2009;75:466-77 pubmed publisher
    ..by coimmunoprecipitation and GST pull-down assays that BK(Ca) channels can associate with endogenous TRPC3 and TRPC6 channels in differentiated cells of a podocyte cell line...
  14. Kanda S, Harita Y, Shibagaki Y, Sekine T, Igarashi T, Inoue T, et al. Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC-?1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis. Mol Biol Cell. 2011;22:1824-35 pubmed publisher
    ..Mutations in the TRPC6 gene are found in patients with focal segmental glomerulosclerosis (FSGS), a proteinuric disease characterized by ..
  15. Gottlieb P, Folgering J, Maroto R, Raso A, Wood T, Kurosky A, et al. Revisiting TRPC1 and TRPC6 mechanosensitivity. Pflugers Arch. 2008;455:1097-103 pubmed
    This article addresses whether TRPC1 or TRPC6 is an essential component of a mammalian stretch-activated mechano-sensitive Ca(2+) permeable cation channel (MscCa)...
  16. Lussier M, Lepage P, Bousquet S, Boulay G. RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. Cell Calcium. 2008;43:432-43 pubmed
    ..approach, we found that RNF24, a new membrane RING-H2 protein, interacted with the ankyrin-like repeat domain of TRPC6. GST pull-down and co-immunoprecipitation assays showed that RNF24 interacted with all TRPCs...
  17. Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T, et al. Regulation of TRPC6 channel activity by tyrosine phosphorylation. J Biol Chem. 2004;279:18887-94 pubmed
    ..direct tyrosine phosphorylation by Src family protein-tyrosine kinases (PTKs) is a novel mechanism for modulating TRPC6 channel activity...
  18. Kwon Y, Hofmann T, Montell C. Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6. Mol Cell. 2007;25:491-503 pubmed
    ..To analyze the role of PI/TRP interactions, we used a biochemical approach, focusing on TRPC6. TRPC6 bound directly to PIs, and with highest potency to phosphatidylinositol 3,4,5-trisphosphate (PIP(3))...
  19. Liao C, Yang H, Zhang R, Sun H, Zhao B, Gao C, et al. The upregulation of TRPC6 contributes to Ca²? signaling and actin assembly in human mesangial cells after chronic hypoxia. Biochem Biophys Res Commun. 2012;421:750-6 pubmed publisher
    ..In the present study, we found that chronic hypoxia enhanced the expression of TRPC6 and TRPC6-dependent Ca(2+) entry, and TRPC6 knockdown inhibited the chronic hypoxia-induced increase in [Ca(2+)]i, ..
  20. Hofstra J, Lainez S, van Kuijk W, Schoots J, Baltissen M, Hoefsloot L, et al. New TRPC6 gain-of-function mutation in a non-consanguineous Dutch family with late-onset focal segmental glomerulosclerosis. Nephrol Dial Transplant. 2013;28:1830-8 pubmed publisher
    ..structural podocyte proteins, including the slit diaphragm-associated transient receptor potential channel C6 (TRPC6)...
  21. Goel M, Sinkins W, Schilling W. Selective association of TRPC channel subunits in rat brain synaptosomes. J Biol Chem. 2002;277:48303-10 pubmed
    ..These results demonstrate that TRPC channels are present in nerve terminals and provide the first direct evidence for selective assembly of channel subunits in vivo. ..
  22. Kini V, Chavez A, Mehta D. A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesis. J Biol Chem. 2010;285:33082-91 pubmed publisher
    ..unrecognized role for PTEN in regulating Ca(2+) entry through transient receptor potential canonical channel 6 (TRPC6) that does not require PTEN phosphatase activity...
  23. Winn M, Conlon P, Lynn K, Farrington M, Creazzo T, Hawkins A, et al. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science. 2005;308:1801-4 pubmed
    ..Here we show that a large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on chromosome 11q, encoding the ion-channel protein transient receptor potential cation channel 6 (TRPC6)...
  24. Chen W, Chen S, Chen C, Chen H, Lin Y, Ho T, et al. Lack of association between transient receptor potential cation channel 6 polymorphisms and primary membranous glomerulonephritis. Ren Fail. 2010;32:666-72 pubmed publisher
    ..Transient receptor potential cation channel 6 (TRPC6) has been identified as causing a familial form of progressive focal and segmental glomerulosclerosis...
  25. SCHLONDORFF J, Pollak M. TRPC6 in glomerular health and disease: what we know and what we believe. Semin Cell Dev Biol. 2006;17:667-74 pubmed
    Mutations in TRPC6, a member of the transient receptor potential (TRP) superfamily of non-selective cation channels, have been identified as causing a familial form of focal segmental glomerulosclerosis, a disease characterized by ..
  26. Schlondorff J, Del Camino D, Carrasquillo R, Lacey V, Pollak M. TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription. Am J Physiol Cell Physiol. 2009;296:C558-69 pubmed publisher
    Mutations in the canonical transient receptor potential channel TRPC6 lead to an autosomal dominant form of human kidney disease characterized histologically by focal and segmental glomerulosclerosis...
  27. Takahashi S, Lin H, Geshi N, Mori Y, Kawarabayashi Y, Takami N, et al. Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6. J Physiol. 2008;586:4209-23 pubmed publisher
    ..the inhibitory role of the nitric oxide (NO)-cGMP-protein kinase G (PKG) pathway on receptor-activated TRPC6 channels in both a heterologous expression system (HEK293 cells) and A7r5 vascular myocytes...
  28. Maruyama Y, Nakanishi Y, Walsh E, Wilson D, Welsh D, Cole W. Heteromultimeric TRPC6-TRPC7 channels contribute to arginine vasopressin-induced cation current of A7r5 vascular smooth muscle cells. Circ Res. 2006;98:1520-7 pubmed
    ..A7r5 cells expressed transcripts encoding TRPC1, TRPC4beta, TRPC6, and TRPC7...
  29. Hofmann T, Obukhov A, Schaefer M, Harteneck C, Gudermann T, Schultz G. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999;397:259-63 pubmed
    ..Thus, hTRPC3 and hTRPC6 represent the first members of a new functional family of second-messenger-operated cation channels, which are activated by diacylglycerol. ..
  30. Mir S, Yavascan O, Berdeli A, Sozeri B. TRPC6 gene variants in Turkish children with steroid-resistant nephrotic syndrome. Nephrol Dial Transplant. 2012;27:205-9 pubmed publisher
    ..FSGS) has been the discovery of a mutant form of canonical transient receptor potential channel 6 (TRPC6) leading to FSGS through unclear mechanisms...
  31. Müller M, Essin K, Hill K, Beschmann H, Rubant S, Schempp C, et al. Specific TRPC6 channel activation, a novel approach to stimulate keratinocyte differentiation. J Biol Chem. 2008;283:33942-54 pubmed publisher
    ..Because we have recently identified hyperforin as a specific TRPC6 activator, we investigated the contribution of TRPC6 to keratinocyte differentiation and proliferation...
  32. Wieder N, Greka A. Calcium, TRPC channels, and regulation of the actin cytoskeleton in podocytes: towards a future of targeted therapies. Pediatr Nephrol. 2016;31:1047-54 pubmed publisher
    ..The identification of the two Ca(2+) permeant channels TRPC5 and TRPC6 as mediators of this pathway not only bolstered the importance of podocyte cytoskeleton dynamics but also revealed ..
  33. Ma R, Liu L, Jiang W, Yu Y, Song H. FK506 ameliorates podocyte injury in type 2 diabetic nephropathy by down-regulating TRPC6 and NFAT expression. Int J Clin Exp Pathol. 2015;8:14063-74 pubmed
    ..The expressions of the canonical transient receptor potential 6 (TRPC6), nuclear factor of activated T-cells (NFAT) and nephrin were detected by Western blotting and qPCR...
  34. Meng K, Xu J, Zhang C, Zhang R, Yang H, Liao C, et al. Calcium sensing receptor modulates extracellular calcium entry and proliferation via TRPC3/6 channels in cultured human mesangial cells. PLoS ONE. 2014;9:e98777 pubmed publisher
    ..Furthermore, stimulation of CaSR by high [Ca2+]o enhanced the expression of TRPC3 and TRPC6 but not TRPC1 and TRPC4, and siRNA targeting TRPC3 and TRPC6 attenuated the CaSR activation-induced [Ca2+]i ..
  35. Riccio A, Medhurst A, Mattei C, Kelsell R, Calver A, Randall A, et al. mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. Brain Res Mol Brain Res. 2002;109:95-104 pubmed
    ..TaqMan real-time quantitative RT-PCR, to investigate the mRNA distribution of human TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7 (hTRPCs) in discrete human brain areas, peripheral tissues as well as a panel of cell-lines...
  36. Ilatovskaya D, Palygin O, Levchenko V, Endres B, Staruschenko A. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci Rep. 2017;7:299 pubmed publisher
    ..influx, and we have previously shown that angiotensin II (Ang II) via canonical transient receptor potential 6 (TRPC6) channels caused increased intracellular Ca2+ flux in podocytes...
  37. Kim E, Roshanravan H, Dryer S. Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: An essential role for integrin signaling. Biochim Biophys Acta. 2015;1853:2610-20 pubmed publisher
    ..We have confirmed that overexpression of Sdc4 core protein increases surface abundance of TRPC6 channels in cultured podocytes, whereas Sdc4 knockdown has the opposite effect...
  38. Wajdner H, Farrington J, Barnard C, Peachell P, Schnackenberg C, Marino J, et al. Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells. Physiol Rep. 2017;5: pubmed publisher
    ..of a TRPC3/6 selective antagonist and agonist (GSK-3503A and GSK-2934A, respectively) did not reveal evidence for TRPC6 contribution to FcεRI-mediated calcium signaling in human mast cells...
  39. Shirakawa H, Katsumoto R, Iida S, Miyake T, Higuchi T, Nagashima T, et al. Sphingosine-1-phosphate induces Ca2+ signaling and CXCL1 release via TRPC6 channel in astrocytes. Glia. 2017;65:1005-1016 pubmed publisher
    ..inhibition of Ca2+ mobilization, MAPK pathway inhibitors, or knockdown of the TRPC channel isoform TRPC6. Taken together, these results demonstrate that S1P induces Ca2+ signaling in astrocytes via Gq
  40. Chung H, Kim G, Holewinski R, Venkatraman V, Zhu G, Bedja D, et al. Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2017;114:E10763-E10771 pubmed publisher
    ..coupled to hyperactivation of the nonselective cation channel, transient receptor potential canonical channel 6 (Trpc6), in isolated myocytes...
  41. Shin H, Hong Y, Jang S, Chae H, Paek S, Moon H, et al. A role of canonical transient receptor potential 5 channel in neuronal differentiation from A2B5 neural progenitor cells. PLoS ONE. 2010;5:e10359 pubmed publisher
    ..Among TRPC subtypes (TRPC1-7), marked expression of TRPC5 and TRPC6 with turned-off TRPC1 expression was observed in neuronal cells differentiated from proliferating A2B5(+) NPCs...
  42. Yang J, Dettmar A, Kronbichler A, Gee H, Saleem M, Kim S, et al. Recent advances of animal model of focal segmental glomerulosclerosis. Clin Exp Nephrol. 2018;22:752-763 pubmed publisher
    ..engineering techniques targeting podocyte expression molecules, such as podocin, CD2-associated protein, and TRPC6 channels. More detailed information about podocytopathy and FSGS can be expected in the coming decade...
  43. Zhang L, Ji T, Wang Q, Meng K, Zhang R, Yang H, et al. Calcium-Sensing Receptor Stimulation in Cultured Glomerular Podocytes Induces TRPC6-Dependent Calcium Entry and RhoA Activation. Cell Physiol Biochem. 2017;43:1777-1789 pubmed publisher
    ..This protective action may be attributed to the RhoA-dependent stabilization of the actin cytoskeleton. However, the underlying mechanisms remain unclear...
  44. Chen Y, Chen J, Wan J, Gao N, Cui J, You D, et al. Bone marrow-derived mesenchymal stem cells ameliorate nephrosis through repair of impaired podocytes. Clin Invest Med. 2017;40:E13-E24 pubmed
    ..and the rest of the kidney was used for detecting the protein and mRNA expression of nephrin, CD2AP, synaptopodin, TRPC6 by real-time quantitative PCR, Western-blot and immunohistochemistry...
  45. Sonneveld R, Hoenderop J, Isidori A, Henique C, Dijkman H, Berden J, et al. Sildenafil Prevents Podocyte Injury via PPAR-γ-Mediated TRPC6 Inhibition. J Am Soc Nephrol. 2017;28:1491-1505 pubmed publisher
    Transient receptor potential channel C6 (TRPC6) gain-of-function mutations and increased TRPC6 expression in podocytes induce glomerular injury and proteinuria...
  46. Diez Bello R, Jardin I, Salido G, Rosado J. Orai1 and Orai2 mediate store-operated calcium entry that regulates HL60 cell migration and FAK phosphorylation. Biochim Biophys Acta Mol Cell Res. 2017;1864:1064-1070 pubmed publisher
    ..On the other hand, the expression of TRPC1, TRPC3 and TRPC6 is almost absent at the transcript and protein level...
  47. Bouron A, Chauvet S, DRYER S, Rosado J. Second Messenger-Operated Calcium Entry Through TRPC6. Adv Exp Med Biol. 2016;898:201-49 pubmed publisher
    Canonical transient receptor potential 6 (TRPC6) proteins assemble into heteromultimeric structures forming non-selective cation channels...
  48. Wu D, Yang H, Winham S, Natanzon Y, Koestler D, Luo T, et al. Mediation analysis of alcohol consumption, DNA methylation, and epithelial ovarian cancer. J Hum Genet. 2018;63:339-348 pubmed publisher
    ..those who did not. cg11016563 resides in TRPC6 which has been previously shown to be overexpressed in EOC...
  49. Li S, Wang J, Wei Y, Liu Y, Ding X, Dong B, et al. Crucial role of TRPC6 in maintaining the stability of HIF-1α in glioma cells under hypoxia. J Cell Sci. 2015;128:3317-29 pubmed publisher
    ..b>TRPC6 was rapidly activated by IGF-1R-PLCγ-IP3R pathway upon hypoxia...
  50. Dionisio N, Albarran L, Berna Erro A, Hernandez Cruz J, Salido G, Rosado J. Functional role of the calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) site of TRPC6 in human platelet activation. Cell Signal. 2011;23:1850-6 pubmed publisher
    ..To assess the basis of CaM/IP(3)Rs binding to the CIRB site of TRPC6 and its role in platelet physiology...
  51. Cayouette S, Bousquet S, Francoeur N, Dupré E, Monet M, Gagnon H, et al. Involvement of Rab9 and Rab11 in the intracellular trafficking of TRPC6. Biochim Biophys Acta. 2010;1803:805-12 pubmed publisher
    TRPC proteins become involved in Ca2+ entry following the activation of Gq-protein coupled receptors. TRPC6 is inserted into the plasma membrane upon stimulation and remains in the plasma membrane as long as the stimulus is present...
  52. Seo K, Rainer P, Shalkey Hahn V, Lee D, Jo S, Andersen A, et al. Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy. Proc Natl Acad Sci U S A. 2014;111:1551-6 pubmed publisher
    ..Increasing evidence supports a role for the transient receptor potential canonical channels TRPC3 and TRPC6 in this pathophysiology...
  53. Qu C, Ding M, Zhu Y, Lu Y, Du J, Miller M, et al. Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. J Med Chem. 2017;60:4680-4692 pubmed publisher
    ..high throughput screening approach, a lead compound with the pyrazolopyrimidine skeleton was identified as a TRPC6 agonist...
  54. Han X, Ross J, Kolumam G, Pi M, Sonoda J, KING G, et al. Cardiovascular Effects of Renal Distal Tubule Deletion of the FGF Receptor 1 Gene. J Am Soc Nephrol. 2018;29:69-80 pubmed publisher
    ..mice showed increased expression of the transient receptor potential cation channel, subfamily C, member 6 (TRPC6), consistent with cardiac effects of soluble Klotho deficiency...
  55. Ambrus L, Oláh A, Oláh T, Balla G, Saleem M, Orosz P, et al. Inhibition of TRPC6 by protein kinase C isoforms in cultured human podocytes. J Cell Mol Med. 2015;19:2771-9 pubmed publisher
    Transient receptor potential canonical-6 (TRPC6) ion channels, expressed at high levels in podocytes of the filtration barrier, are recently implicated in the pathogenesis of various forms of proteinuric kidney diseases...
  56. Pousada G, Baloira A, Valverde D. Molecular and clinical analysis of TRPC6 and AGTR1 genes in patients with pulmonary arterial hypertension. Orphanet J Rare Dis. 2015;10:1 pubmed publisher
    ..The aim of this study was to analyze 5'UTR region in canonical transient receptor potential isoform 6 (TRPC6) and 3'UTR region in Angiotensin II type I receptor (AGTR1) genes in patients with idiopathic and associated PAH...
  57. So I, Chae M, Kim S, Lee S. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces the change of calcium mobilization via TRPC ion channels in cultured human corporal smooth muscle cells. Int J Impot Res. 2005;17:475-83 pubmed
    ..The size of ILPC at -60 mV was -55.3+/-6.3 pA (n=8). The transcript of transient receptor potential channel 6 (TRPC6) was detected in human corporal myocytes. We also found one splicing variant of TRPC6, TRPC6alpha...
  58. Nishida M, Watanabe K, Nakaya M, Kurose H. [Mechanism of cardiac hypertrophy via diacylglycerol-sensitive TRPC channels]. Yakugaku Zasshi. 2010;130:295-302 pubmed
    ..of diacylglycerol (DAG)-responsive canonical transient receptor potential (TRPC) subfamily channels (TRPC3 and TRPC6) mediate membrane depolarization induced by G(q) protein-coupled receptor stimulation...
  59. Hirschler Laszkiewicz I, Tong Q, Waybill K, Conrad K, Keefer K, Zhang W, et al. The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin. J Biol Chem. 2011;286:30636-46 pubmed publisher
    ..Transient receptor potential (TRP) channels TRPC3 and homologous TRPC6 are expressed on normal human erythroid precursors, but Epo stimulates an increase in [Ca(2+)](i) through TRPC3 ..
  60. Chaudhuri P, Colles S, Bhat M, Van Wagoner D, Birnbaumer L, Graham L. Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement. Mol Biol Cell. 2008;19:3203-11 pubmed publisher
    ..Here, we report a novel mechanism for opening TRPC channels in which TRPC6 activation initiates a cascade resulting in TRPC5 translocation...
  61. Song J, Wang Y, Li X, Shen Y, Yin M, Guo Y, et al. Critical role of TRPC6 channels in the development of human renal cell carcinoma. Mol Biol Rep. 2013;40:5115-22 pubmed publisher
    ..In this study, we investigated the role of TRPC6 in the development of human RCC...
  62. Chen W, Oberwinkler H, Werner F, Gaßner B, Nakagawa H, Feil R, et al. Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels. Arterioscler Thromb Vasc Biol. 2013;33:2121-9 pubmed publisher
    ..Conversely, direct activation of TRPC6 with hyperforin replicated the hyperpermeability responses to histamine...
  63. Kalwa H, Storch U, Demleitner J, Fiedler S, Mayer T, Kannler M, et al. Phospholipase C epsilon (PLCε) induced TRPC6 activation: a common but redundant mechanism in primary podocytes. J Cell Physiol. 2015;230:1389-99 pubmed publisher
    ..Patients with focal segmental glomerulosclerosis (FSGS) express gain-of-function mutants of TRPC6, while others carry loss-of-function mutants of PLCε, raising the intriguing possibility that both proteins ..
  64. Ramkumar N, Gao Y, Kohan D. Characterization of flow-regulated cortical collecting duct endothelin-1 production. Physiol Rep. 2017;5: pubmed publisher
    ..b>TRPC6, but not other CD-expressed TRP channels (TRPC3, 4, and 5, or TRPV4) played a role in the ET-1 flow response...
  65. Madan E, Gogna R, Keppler B, Pati U. p53 increases intra-cellular calcium release by transcriptional regulation of calcium channel TRPC6 in GaQ3-treated cancer cells. PLoS ONE. 2013;8:e71016 pubmed publisher
    ..there is an increase in intracellular calcium levels by transcriptional regulation of a novel calcium channel gene TRPC6. p53 directly binds to a 22 bp response element in the TRPC6 gene promoter and increase its mRNA and protein ..
  66. Carrillo C, Hichami A, Andreoletti P, Cherkaoui Malki M, Del Mar Cavia M, Abdoul Azize S, et al. Diacylglycerol-containing oleic acid induces increases in [Ca(2+)](i) via TRPC3/6 channels in human T-cells. Biochim Biophys Acta. 2012;1821:618-26 pubmed publisher
    ..Furthermore, POG-induced increases in [Ca(2+)](i) were due to the opening of TRPC3/TRPC6 channels as silencing of TRPC3 and TRPC6 genes by shRNA abolished calcium entry...
  67. Thilo F, Liu Y, Krueger K, Förste N, Wittstock A, Scholze A, et al. Do cysteine residues regulate transient receptor potential canonical type 6 channel protein expression?. Antioxid Redox Signal. 2012;16:452-7 pubmed publisher
    The regulation of calcium influx through transient receptor potential canonical type 6 (TRPC6) channel is mandatory for the activity of human monocytes...
  68. Nishioka K, Nishida M, Ariyoshi M, Jian Z, Saiki S, Hirano M, et al. Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel. Arterioscler Thromb Vasc Biol. 2011;31:2278-86 pubmed publisher
    ..Cilostazol specifically suppressed diacylglycerol-activated TRPC channels (TRPC3/TRPC6/TRPC7) through protein kinase A (PKA)-dependent phosphorylation of TRPC channels in HEK293 cells...
  69. Strielkov I, Pak O, Sommer N, Weissmann N. Recent advances in oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction. J Appl Physiol (1985). 2017;:jap.00103.2017 pubmed publisher
    ..Other essential components are voltage-dependent potassium, and possibly L-type, TRPC6 and TRPV4 channels. The release of arachidonic acid metabolites appears also to be involved in HPV regulation...
  70. Kuang X, Huang W, Xu H, Shi Y, Zhang X, Niu X, et al. 254C>G: a TRPC6 promoter variation associated with enhanced transcription and steroid-resistant nephrotic syndrome in Chinese children. Pediatr Res. 2013;74:511-6 pubmed publisher
    Mutations in canonical transient receptor potential channel 6 (TRPC6) have been identified as responsible for the development of focal segmental glomerulosclerosis, a proteinuric disease with steroid resistance and poor prognosis...
  71. Graham S, Gorin Y, Abboud H, Ding M, Lee D, Shi H, et al. Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes. Am J Physiol Cell Physiol. 2011;301:C304-15 pubmed publisher
    ..oxygen species (ROS) and protein kinase C (PKC), in the diabetes-induced canonical transient receptor potential 6 (TRPC6) downregulation...
  72. Graham S, Ding M, Sours Brothers S, Yorio T, Ma J, Ma R. Downregulation of TRPC6 protein expression by high glucose, a possible mechanism for the impaired Ca2+ signaling in glomerular mesangial cells in diabetes. Am J Physiol Renal Physiol. 2007;293:F1381-90 pubmed
    ..Western blots and real-time PCR were used to evaluate the expression level of TRPC6 protein and mRNA, respectively...
  73. Wang J, Fu X, Yang K, Jiang Q, Chen Y, Jia J, et al. Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs. Cardiovasc Res. 2015;107:108-18 pubmed publisher
    ..HIF-1) and bone morphogenetic protein-4 (BMP4) up-regulate transient receptor potential canonical (TRPC) 1 and TRPC6, resulting in increased basal intracellular Ca(2+) concentration ([Ca(2+)]i) in pulmonary arterial smooth muscle ..