TRPA1

Summary

Gene Symbol: TRPA1
Description: transient receptor potential cation channel subfamily A member 1
Alias: ANKTM1, FEPS, FEPS1, transient receptor potential cation channel subfamily A member 1, ankyrin-like with transmembrane domains 1, transformation-sensitive protein p120
Species: human
Products:     TRPA1

Top Publications

  1. Wang Y, Chang R, Waters H, McKemy D, Liman E. The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J Biol Chem. 2008;283:32691-703 pubmed publisher
    The transient receptor potential A1 (TRPA1) channel is the molecular target for environmental irritants and pungent chemicals, such as cinnamaldehyde and mustard oil...
  2. Chen J, Zhang X, Kort M, Huth J, Sun C, Miesbauer L, et al. Molecular determinants of species-specific activation or blockade of TRPA1 channels. J Neurosci. 2008;28:5063-71 pubmed publisher
    b>TRPA1 is an excitatory, nonselective cation channel implicated in somatosensory function, pain, and neurogenic inflammation...
  3. Atoyan R, Shander D, Botchkareva N. Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin. J Invest Dermatol. 2009;129:2312-5 pubmed publisher
  4. Jaquemar D, Schenker T, Trueb B. An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts. J Biol Chem. 1999;274:7325-33 pubmed
    ..Overexpression in eukaryotic cells appears to interfere with normal growth, suggesting that it might play a direct or indirect role in signal transduction and growth control. ..
  5. Hinman A, Chuang H, Bautista D, Julius D. TRP channel activation by reversible covalent modification. Proc Natl Acad Sci U S A. 2006;103:19564-8 pubmed
    Allyl isothiocyanate, the pungent principle of wasabi and other mustard oils, produces pain by activating TRPA1, an excitatory ion channel on sensory nerve endings...
  6. Nassini R, Pedretti P, Moretto N, Fusi C, Carnini C, Facchinetti F, et al. Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. PLoS ONE. 2012;7:e42454 pubmed publisher
    The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism...
  7. Spahn V, Stein C, Zöllner C. Modulation of transient receptor vanilloid 1 activity by transient receptor potential ankyrin 1. Mol Pharmacol. 2014;85:335-44 pubmed publisher
    ..Transient receptor potential ankyrin 1 (TRPA1) is coexpressed with TRPV1. It is activated by compounds that cause a burning sensation (e.g...
  8. Jordt S, Bautista D, Chuang H, McKemy D, Zygmunt P, Hogestatt E, et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature. 2004;427:260-5 pubmed
    ..Both allyl isothiocyanate and THC mediate their excitatory effects by activating ANKTM1, a member of the TRP ion channel family recently implicated in the detection of noxious cold...
  9. Garcia Anoveros J, Nagata K. TRPA1. Handb Exp Pharmacol. 2007;:347-62 pubmed
    The TRPA1 protein has up to 18 N-terminal and presumed cytoplasmic ankyrin repeats followed by the six membrane spanning and single pore-loop domains characteristic of all TRPs...

More Information

Publications108 found, 100 shown here

  1. Nozawa K, Kawabata Shoda E, Doihara H, Kojima R, Okada H, Mochizuki S, et al. TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells. Proc Natl Acad Sci U S A. 2009;106:3408-13 pubmed publisher
    ..Here, we demonstrate that the transient receptor potential (TRP) cation channel TRPA1, which is activated by pungent compounds or cold temperature, is highly expressed in EC cells...
  2. Kremeyer B, Lopera F, Cox J, Momin A, Rugiero F, Marsh S, et al. A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. Neuron. 2010;66:671-80 pubmed publisher
    ..Candidate gene sequencing identified a point mutation (N855S) in the S4 transmembrane segment of TRPA1, a key sensor for environmental irritants...
  3. Sadofsky L, Boa A, Maher S, Birrell M, Belvisi M, Morice A. TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids. Pharmacol Res. 2011;63:30-6 pubmed publisher
    The nociceptor TRPA1 is thought to be activated through covalent modification of specific cysteine residues on the N terminal of the channel...
  4. Nagatomo K, Ishii H, Yamamoto T, Nakajo K, Kubo Y. The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression. Biophys J. 2010;99:3609-18 pubmed publisher
    The transient receptor potential A1 channel (TRPA1) is activated by various compounds, including isothiocyanates, menthol, and cinnamaldehyde...
  5. Mukhopadhyay I, Gomes P, Aranake S, Shetty M, Karnik P, Damle M, et al. Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells. J Recept Signal Transduct Res. 2011;31:350-8 pubmed publisher
    The transient receptor potential subfamily A member 1 (TRPA1) is a non-selective cation channel implicated in the pathogenesis of several airway diseases like asthma and chronic obstructive pulmonary disease (COPD)...
  6. Cordero Morales J, Gracheva E, Julius D. Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli. Proc Natl Acad Sci U S A. 2011;108:E1184-91 pubmed publisher
    ..Mammalian TRPA1 channels are activated by chemically reactive irritants, whereas snake and Drosophila TRPA1 orthologs are ..
  7. Komatsu T, Uchida K, Fujita F, Zhou Y, Tominaga M. Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner. Pflugers Arch. 2012;463:549-59 pubmed publisher
    Transient receptor potential ankyrin 1 (TRPA1) is a calcium-permeable non-selective cation channel that is mainly expressed in primary nociceptive neurons...
  8. Sura L, Zíma V, Marsakova L, Hynkova A, Barvik I, Vlachova V. C-terminal acidic cluster is involved in Ca2+-induced regulation of human transient receptor potential ankyrin 1 channel. J Biol Chem. 2012;287:18067-77 pubmed publisher
    The transient receptor potential ankyrin 1 (TRPA1) channel is a Ca(2+)-permeable cation channel whose activation results from a complex synergy between distinct activation sites, one of which is especially important for determining its ..
  9. Dai Y, Wang S, Tominaga M, Yamamoto S, Fukuoka T, Higashi T, et al. Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest. 2007;117:1979-87 pubmed
    ..Transient receptor potential A1 (TRPA1) is an excitatory ion channel on primary sensory nerves of pain pathway...
  10. Taylor Clark T, McAlexander M, Nassenstein C, Sheardown S, Wilson S, Thornton J, et al. Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal. J Physiol. 2008;586:3447-59 pubmed publisher
    ..One such alkenal, 4-hydroxynonenal (4HNE), activates TRPA1 in cultured sensory neurones...
  11. Eid S, Crown E, Moore E, Liang H, Choong K, Dima S, et al. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain. 2008;4:48 pubmed publisher
    ..The recent discovery and description of the transient receptor potential family of receptors including TRPV1 and TRPA1 has provided a number of potential new therapeutic targets for treating chronic pain...
  12. Taylor Clark T, Kiros F, Carr M, McAlexander M. Transient receptor potential ankyrin 1 mediates toluene diisocyanate-evoked respiratory irritation. Am J Respir Cell Mol Biol. 2009;40:756-62 pubmed publisher
    ..Recent studies have demonstrated that transient receptor potential ankyrin 1 (TRPA1), an ion channel largely restricted to a subset of capsaicin-sensitive sensory nerves, functions as a transducer ..
  13. Samad A, Sura L, Benedikt J, Ettrich R, Minofar B, Teisinger J, et al. The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1. Biochem J. 2011;433:197-204 pubmed publisher
    The ankyrin transient receptor potential channel TRPA1 is a non-selective cationic channel that is expressed by sensory neurons, where it can be activated by pungent chemicals, such as AITC (allyl isothiocyanate), cinnamon or allicin, by ..
  14. Jain A, Brönneke S, Kolbe L, Stäb F, Wenck H, Neufang G. TRP-channel-specific cutaneous eicosanoid release patterns. Pain. 2011;152:2765-72 pubmed publisher
    ..Herein we investigated the functional expression of TRPV1 and TRPA1 in human keratinocytes and fibroblasts and assessed proinflammatory lipid mediator release upon their stimulation ..
  15. Hatano N, Itoh Y, Suzuki H, Muraki Y, Hayashi H, Onozaki K, et al. Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release. J Biol Chem. 2012;287:31962-72 pubmed publisher
    Transient receptor potential ankyrin repeat 1 (TRPA1) forms calcium (Ca(2+))- and zinc (Zn(2+))-permeable ion channels that sense noxious substances...
  16. Choi J, Di Nardo A. Skin neurogenic inflammation. Semin Immunopathol. 2018;40:249-259 pubmed publisher
    ..The Mas-related G protein-coupled receptors (Mrgpr) family as well as transient receptor potential ankyrin 1 (TRPA1) and protease activated receptor 2(Par2) have important roles in itch and inflammation...
  17. Shi H, Liu C, Ding L, Zheng Y, Fei X, Lu L, et al. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. World J Gastroenterol. 2015;21:4852-63 pubmed publisher
    ..Blockers of transient receptor potential (TRP) vanilloid 1 (TRPV1) (Ruthenium Red) and TRP ankyrin-1 (TRPA1) (HC-030031) and activator of protease-activated receptor (PAR)4 increased the pain pressure threshold, whereas ..
  18. Kichko T, Neuhuber W, Kobal G, Reeh P. The roles of TRPV1, TRPA1 and TRPM8 channels in chemical and thermal sensitivity of the mouse oral mucosa. Eur J Neurosci. 2017;: pubmed publisher
    ..TRPV1 (vanilloid type 1), TRPA1 (ankyrin 1) and TRPM8 (melastatin 8) not only elicit action potential signaling through trigeminal nerves, ..
  19. Chen L, Zhang J, Suo H, Wang W, Wang H, Zhang Y, et al. Preventive Effects of Different Fermentation Times of Shuidouchi on Diphenoxylate-Induced Constipation in Mice. Foods. 2019;8: pubmed publisher
    ..72-SDC also raised ghrelin mRNA expression in gastric tissue and transient receptor potential ankyrin 1 (TRPA1) mRNA expression in colon tissue compared to the control group mice; these effects were stronger than those of ..
  20. Lin Y, Chen Z, Tang J, Cao P, Shi R. Acrolein Contributes to the Neuropathic Pain and Neuron Damage after Ischemic-Reperfusion Spinal Cord Injury. Neuroscience. 2018;384:120-130 pubmed publisher
    ..hyperalgesia through elevated activation, upregulating, and sensitizing transient receptor potential ankyrin 1 (TRPA1) in sensory neurons in dorsal root ganglia...
  21. Deak E, Rosta J, Boros K, Kis G, Santha P, Messlinger K, et al. Chronic adriamycin treatment impairs CGRP-mediated functions of meningeal sensory nerves. Neuropeptides. 2018;69:46-52 pubmed publisher
    ..receptor potential vanilloid 1 (TRPV1) receptor agonist, or acrolein, a transient receptor potential ankyrin 1 (TRPA1) receptor agonist, which induce the release of calcitonin gene-related peptide (CGRP) from meningeal afferents...
  22. Nucci Martins C, Martins D, Nascimento L, Venzke D, Oliveira A, Frederico M, et al. Ameliorative potential of standardized fruit extract of Pterodon pubescens Benth on neuropathic pain in mice: Evidence for the mechanisms of action. J Ethnopharmacol. 2015;175:273-86 pubmed publisher
    ..glutamate receptor agonists, proinflammatory cytokines such as IL-1β and TNF-α, as well as TRPV1 and TRPA1 agonists. In addition, we also investigated the safety profile of prolonged treatment with EEPp in mice...
  23. Foote J, Behe P, Frampton M, Levine A, Segal A. An Exploration of Charge Compensating Ion Channels across the Phagocytic Vacuole of Neutrophils. Front Pharmacol. 2017;8:94 pubmed publisher
    ..from knock-out mouse models including CLIC1, ClC3, ClC4, ClC7, KCC3, KCNQ1, KCNE3, KCNJ15, TRPC1/3/5/6, TRPA1/TRPV1, TRPM2, and TRPV2, and double knockouts of CLIC1, ClC3, KCC3, TRPM2, and KCNQ1 with HVCN1, and humans with ..
  24. Cevikbas F, Wang X, Akiyama T, Kempkes C, Savinko T, Antal A, et al. A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1. J Allergy Clin Immunol. 2014;133:448-60 pubmed publisher
    ..reduced in TRPV1-deficient and transient receptor channel potential cation channel ankyrin subtype 1 (TRPA1)-deficient mice but not in c-kit or proteinase-activated receptor 2 mice...
  25. Sághy Ã, SzÅ‘ke Ã, Payrits M, Helyes Z, Börzsei R, Erostyák J, et al. Evidence for the role of lipid rafts and sphingomyelin in Ca2+-gating of Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve terminals. Pharmacol Res. 2015;100:101-16 pubmed publisher
    ..Receptor Potential (TRP) cation channels, such as TRP Vanilloid 1 and TRP Ankyrin repeat domain 1 (TRPV1 and TRPA1) are nocisensors playing important role to signal pain...
  26. Albarrán L, Lopez J, Dionisio N, Smani T, Salido G, Rosado J. Transient receptor potential ankyrin-1 (TRPA1) modulates store-operated Ca(2+) entry by regulation of STIM1-Orai1 association. Biochim Biophys Acta. 2013;1833:3025-3034 pubmed publisher
    b>TRPA1 is a non-selective Ca(2+) permeable channel located in the plasma membrane that functions as a cellular sensor detecting mechanical, chemical and thermal stimuli, being a component of neuronal, epithelial, blood and smooth muscle ..
  27. Moilanen L, Hämäläinen M, Nummenmaa E, Ilmarinen P, Vuolteenaho K, Nieminen R, et al. Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis. Osteoarthritis Cartilage. 2015;23:2017-26 pubmed publisher
    ..MIA induces acute inflammation, cartilage degradation and joint pain. Transient Receptor Potential Ankyrin 1 (TRPA1) is an ion channel known to mediate nociception and neurogenic inflammation...
  28. Viana F. TRPA1 channels: molecular sentinels of cellular stress and tissue damage. J Physiol. 2016;594:4151-69 pubmed publisher
    b>TRPA1 is a non-selective cation channel expressed in mammalian peripheral pain receptors, with a major role in chemonociception. TRPA1 has also been implicated in noxious cold and mechanical pain sensation...
  29. Utsumi D, Matsumoto K, Tsukahara T, Amagase K, Tominaga M, Kato S. Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 contribute to the progression of colonic inflammation in dextran sulfate sodium-induced colitis in mice: Links to calcitonin gene-related peptide and substance P. J Pharmacol Sci. 2018;136:121-132 pubmed publisher
    Transient receptor potential (TRP) vanilloid 1 (TRPV1) and TRP ankyrin 1 (TRPA1), which are non-selective cation channels, play important roles in the sensation of pain...
  30. Zhang X, Li L, McNaughton P. Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150. Neuron. 2008;59:450-61 pubmed publisher
    ..If binding is prevented, then sensitization by both bradykinin and PGE(2) is abrogated. AKAP79/150 is therefore a final common element in heat hyperalgesia, on which the effects of multiple proinflammatory mediators converge. ..
  31. Billeter A, Galbraith N, Walker S, Lawson C, Gardner S, Sarojini H, et al. TRPA1 mediates the effects of hypothermia on the monocyte inflammatory response. Surgery. 2015;158:646-54 pubmed publisher
    ..Specific inhibitors of TRPA1 (HC- 030031) and a specific activator of TRPV1 (capsaicin) were used to block or activate TRPA1 and TRPV1, ..
  32. Eberhardt M, Schillers F, Eberhardt E, Risser L, de la Roche J, Herzog C, et al. Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1. Sci Rep. 2017;7:12775 pubmed publisher
    The irritant receptor TRPA1 was suggested to mediate analgesic, antipyretic but also pro-inflammatory effects of the non-opioid analgesic acetaminophen, presumably due to channel activation by the reactive metabolites parabenzoquinone (..
  33. Anand U, Otto W, Facer P, Zebda N, Selmer I, Gunthorpe M, et al. TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons. Neurosci Lett. 2008;438:221-7 pubmed publisher
    b>TRPA1 is a receptor expressed by sensory neurons, that is activated by low temperature (<17 degrees C) and plant derivatives such as cinnamaldehyde and isoeugenol, to elicit sensations including pain...
  34. Marmiroli P, Cavaletti G, Carozzi V, Riva B, Lim D, Genazzani A. Calcium-related neurotoxicity of oxaliplatin: understanding the mechanisms to drive therapy. Curr Med Chem. 2015;22:3682-94 pubmed
    ..In particular, we will focus on the pre-clinical evidence suggesting that TRPV1, TRPM8 or TRPA1 might be involved, as these appear particularly amenable to pharmacological modulation.
  35. Derouiche S, Mariot P, Warnier M, Vancauwenberghe E, Bidaux G, Gosset P, et al. Activation of TRPA1 Channel by Antibacterial Agent Triclosan Induces VEGF Secretion in Human Prostate Cancer Stromal Cells. Cancer Prev Res (Phila). 2017;10:177-187 pubmed publisher
    ..the first time that environmentally relevant concentrations of TCS activate a cation channel of the TRP family, TRPA1 (Transient Receptor Potential Ankirin 1), in primary cultured human prostate cancer stromal cells...
  36. Jaramillo I, Sturrock A, Ghiassi H, Woller D, Deering Rice C, Lighty J, et al. Effects of fuel components and combustion particle physicochemical properties on toxicological responses of lung cells. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2017;:1-12 pubmed publisher
    ..Finally, AD and RD were more potent activators of TRPA1 than BD, and while neither the TRPA1 antagonist HC-030031 nor the antioxidant N-acetylcysteine (NAC) affected ..
  37. Cruz Orengo L, Dhaka A, Heuermann R, Young T, Montana M, Cavanaugh E, et al. Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. Mol Pain. 2008;4:30 pubmed publisher
    ..and allyl isothiocyanate (AITC), derivatives of cinnamon and mustard oil respectively, activate thermoTRP member TRPA1 via direct modification of channel cysteine residues...
  38. Logashina Y, Mosharova I, Korolkova Y, Shelukhina I, Dyachenko I, Palikov V, et al. Peptide from Sea Anemone Metridium senile Affects Transient Receptor Potential Ankyrin-repeat 1 (TRPA1) Function and Produces Analgesic Effect. J Biol Chem. 2017;292:2992-3004 pubmed publisher
    The transient receptor potential ankyrin-repeat 1 (TRPA1) is an important player in pain and inflammatory pathways. It is a promising target for novel drug development for the treatment of a number of pathological states...
  39. Kaur R, Chaudhary S, Kumar K, Gupta M, Rawal R. Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review. Eur J Med Chem. 2017;132:108-134 pubmed publisher
    ..anti-tubercular, antifungal anticancer, antibacterial, antifilarial, antihyperglycemic, antihypertensive, analgesic, anti-convulsant, antioxidant, anti-TRPA1, anti-SARS, and anti-cancer activity and ?1a binding affinity.
  40. Oda M, Kubo Y, Saitoh O. Sensitivity of Takifugu TRPA1 to thermal stimulations analyzed in oocytes expression system. Neuroreport. 2017;: pubmed publisher
    ..The results indicated that these thermal sensitivities of fish TRPA1 are clearly different from those of TRPA1s of tetrapod vertebrates.
  41. May D, Baastrup J, Nientit M, Binder A, Schünke M, Baron R, et al. Differential expression and functionality of TRPA1 protein genetic variants in conditions of thermal stimulation. J Biol Chem. 2012;287:27087-94 pubmed publisher
    The role of genetic modifications of the TRPA1 receptor has been well documented in inflammatory and neuropathic pain...
  42. El Karim I, McCrudden M, McGahon M, Curtis T, Jeanneau C, Giraud T, et al. Biodentine Reduces Tumor Necrosis Factor Alpha-induced TRPA1 Expression in Odontoblastlike Cells. J Endod. 2016;42:589-95 pubmed publisher
    ..TRP) ion channels have emerged as important cellular sensors in both neuronal and non-neuronal cells, with TRPA1 playing a central role in nociception and neurogenic inflammation...
  43. Clark M, McCumsey S, Lopez Darwin S, Heckscher E, Doe C. Functional Genetic Screen to Identify Interneurons Governing Behaviorally Distinct Aspects of Drosophila Larval Motor Programs. G3 (Bethesda). 2016;6:2023-31 pubmed publisher
    ..lines-chosen for sparse neuronal expression-to ectopically express the warmth-inducible neuronal activator TrpA1, and screened for locomotor defects...
  44. De Logu F, Nassini R, Materazzi S, Carvalho Gonçalves M, Nosi D, Rossi Degl Innocenti D, et al. Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice. Nat Commun. 2017;8:1887 pubmed publisher
    It is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by nociceptors, contribute to neuropathic pain. Here we show that TRPA1 is also expressed in Schwann cells...
  45. Than J, Li L, Hasan R, Zhang X. Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel-expressing sensory neurons by the pruritogen chloroquine. J Biol Chem. 2013;288:12818-27 pubmed publisher
    ..Pain inhibits itch, whereas cold inhibits both pain and itch. TRPV1 and TRPA1 channels transduce pain and itch, whereas TRPM8 transduces cold...
  46. Nassini R, Fusi C, Materazzi S, Coppi E, Tuccinardi T, Marone I, et al. The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives. Br J Pharmacol. 2015;172:3397-411 pubmed publisher
    ..The transient receptor potential ankyrin 1 (TRPA1) channel, expressed by nociceptors, is emerging as a major pain transduction pathway...
  47. Nagarajan Y, Rychkov G, Peet D. Modulation of TRP Channel Activity by Hydroxylation and Its Therapeutic Potential. Pharmaceuticals (Basel). 2017;10: pubmed publisher
    Two transient receptor potential (TRP) channels-TRPA1 and TRPV3-are post-translationally hydroxylated, resulting in oxygen-dependent regulation of channel activity...
  48. Walker J, Ley J, Schwerzler J, Lieder B, Beltrán L, Ziemba P, et al. Nonivamide, a capsaicin analogue, exhibits anti-inflammatory properties in peripheral blood mononuclear cells and U-937 macrophages. Mol Nutr Food Res. 2017;61: pubmed publisher
    ..In addition, cotreatment of U-937 with the trigeminally active compound and an antagonist of TRPV1 or TRPA1 abolished the anti-inflammatory activity...
  49. Moran M. TRP Channels as Potential Drug Targets. Annu Rev Pharmacol Toxicol. 2018;58:309-330 pubmed publisher
    ..Compounds that modulate TRP vanilloid 1 (TRPV1), TRPV3, TRPV4, TRP ankyrin 1 (TRPA1), and TRP melastatin 8 (TRPM8) have all entered clinical trials...
  50. Du S, Araki I, Kobayashi H, Zakoji H, Sawada N, Takeda M. Differential expression profile of cold (TRPA1) and cool (TRPM8) receptors in human urogenital organs. Urology. 2008;72:450-5 pubmed publisher
    ..In addition to TRPM8, a cool receptor, TRPA1 is recently recognized as a cold receptor. TRPA1 is also a candidate for mechanosensor and/or nociceptor...
  51. Kaimoto T, Hatakeyama Y, Takahashi K, Imagawa T, Tominaga M, Ohta T. Involvement of transient receptor potential A1 channel in algesic and analgesic actions of the organic compound limonene. Eur J Pain. 2016;20:1155-65 pubmed publisher
    b>TRPA1 is a Ca-permeable nonselective cation channel expressed in sensory neurons and acts as a nocisensor. Recent reports show that some monoterpenes, a group of naturally occurring organic compounds, modulate TRP channel activity...
  52. Stueber T, Eberhardt M, Caspi Y, Lev S, Binshtok A, Leffler A. Differential cytotoxicity and intracellular calcium-signalling following activation of the calcium-permeable ion channels TRPV1 and TRPA1. Cell Calcium. 2017;68:34-44 pubmed publisher
    ..The closely related ion channel TRPA1 is also activated by irritants, but it is unclear if and how TRPA1 mediates cell death...
  53. Du G, Li J, Liu W, Liu Y, Zhao B, Li H, et al. The combination of TRPM8 and TRPA1 expression causes an invasive phenotype in lung cancer. Tumour Biol. 2014;35:1251-61 pubmed publisher
    ..progression and that the molecular sensors for cold are the transient receptor potential (TRP) channels TRPM8 and TRPA1. To evaluate the contribution of TRPM8 and TRPA1 to cancer malignancy, we screened cell subpopulations from Lewis ..
  54. Fischer L, Lavoranti M, de Oliveira Borges M, Miksza A, Sardi N, Martynhak B, et al. TRPA1, substance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception. Inflamm Res. 2017;66:311-322 pubmed publisher
    Although TRPA1, SP, histamine and 5-hydroxytryptamine (5-HT) have recognized contribution to nociceptive mechanisms, little is known about how they interact with each other to mediate inflammatory pain in vivo...
  55. Arenas O, Zaharieva E, Para A, Vásquez Doorman C, Petersen C, Gallio M. Activation of planarian TRPA1 by reactive oxygen species reveals a conserved mechanism for animal nociception. Nat Neurosci. 2017;20:1686-1693 pubmed publisher
    ..elicit robust escape behaviors in the planarian Schmidtea mediterranea and that the conserved ion channel TRPA1 is required for these responses. TRPA1-mutant Drosophila flies are also defective in noxious-heat responses...
  56. Paulsen C, Armache J, Gao Y, Cheng Y, Julius D. Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature. 2015;520:511-7 pubmed publisher
    The TRPA1 ion channel (also known as the wasabi receptor) is a detector of noxious chemical agents encountered in our environment or produced endogenously during tissue injury or drug metabolism...
  57. Tsagareli M, Nozadze I, Tsiklauri N, Gurtskaia G. Non-steroidal anti-inflammatory drugs attenuate agonist-evoked activation of transient receptor potential channels. Biomed Pharmacother. 2018;97:745-751 pubmed publisher
    ..NSAIDs (diclofenac, ketorolac, and xefocam) affect thermal and mechanical hyperalgesia following the activation of TRPA1 and TRPV1 channels...
  58. Nagata K. TRP channels as target sites for insecticides: physiology, pharmacology and toxicology. Invert Neurosci. 2007;7:31-7 pubmed
    ..Our group has focused on TRPA1 channels and revealed their expression pattern, ion channel kinetics and pharmacological characteristics...
  59. Wang X, Tian B, Huang Y, Peng X, Chen L, Li J, et al. Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice. Sci Rep. 2015;5:16768 pubmed publisher
    ..Moreover, local application of capsaizapine (TRPV1 blocker) or HC-030031 (TRPA1 blocker) had no effects on NaHS-evoked scratching. Strikingly, pharmacological blockade and silencing of Cav3...
  60. Bang S, Hwang S. Polymodal ligand sensitivity of TRPA1 and its modes of interactions. J Gen Physiol. 2009;133:257-62 pubmed publisher
  61. Ohkawara S, Tanaka Kagawa T, Furukawa Y, Jinno H. Methylglyoxal activates the human transient receptor potential ankyrin 1 channel. J Toxicol Sci. 2012;37:831-5 pubmed
    ..In the present study, we investigated the effect of MG on transient receptor potential ankyrin 1 (TRPA1) activation in human TRPA1-expressing HEK293 cells...
  62. Liu B, Tai Y, Caceres A, Achanta S, Balakrishna S, Shao X, et al. Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice. PLoS ONE. 2016;11:e0165200 pubmed publisher
    ..Here, we observed that OxPAPC dose-dependently and selectively activated human TRPA1 nociceptive ion channels expressed in HEK293 cells in vitro, without any effect on other TRP channels, including ..
  63. Zíma V, Witschas K, Hynkova A, Zímová L, Barvík I, Vlachova V. Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state. Neuropharmacology. 2015;93:294-307 pubmed publisher
    The ankyrin transient receptor potential channel TRPA1 is a polymodal sensor for noxious stimuli, and hence a promising target for treating chronic pain...
  64. Nakajima S, Hira T, Iwaya H, Hara H. Zinc directly stimulates cholecystokinin secretion from enteroendocrine cells and reduces gastric emptying in rats. Mol Cell Endocrinol. 2016;430:108-14 pubmed publisher
    ..Upon inhibition of transient receptor potential ankyrin 1 (TRPA1), extracellular zinc failed to increase intracellular Ca(2+) and subsequent CCK secretion...
  65. Tominaga M. [Thermosensitive TRP channels and brain function]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2016;36:37-41 pubmed
    Capsaicin receptor TRPV1 and wasabi receptor TRPA1 are expressed in the unmyelinated C fiber nociceptors and activated by various nociceptive stimuli causing pain in our body...
  66. Zappia K, O Hara C, Moehring F, Kwan K, Stucky C. Sensory Neuron-Specific Deletion of TRPA1 Results in Mechanical Cutaneous Sensory Deficits. Eneuro. 2017;4: pubmed publisher
    The nonselective cation channel transient receptor potential ankyrin 1 (TRPA1) is known to be a key contributor to both somatosensation and pain...
  67. Nummenmaa E, Hamalainen M, Moilanen L, Paukkeri E, Nieminen R, Moilanen T, et al. Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in primary human osteoarthritic chondrocytes. Arthritis Res Ther. 2016;18:185 pubmed publisher
    Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel, widely expressed in neuronal cells and involved in nociception and neurogenic inflammation...
  68. Lu Y, Piplani H, McAllister S, Hurt C, Gross E. Transient Receptor Potential Ankyrin 1 Activation within the Cardiac Myocyte Limits Ischemia-reperfusion Injury in Rodents. Anesthesiology. 2016;125:1171-1180 pubmed
    ..Here, the authors address whether the transient receptor potential ankyrin 1 (TRPA1) channel, important in pain signaling, is present in cardiac myocytes and regulates cardiac ischemia-reperfusion ..
  69. Araújo D, Miya Coreixas V, Pandolfo P, Calaza K. Cannabinoid receptors and TRPA1 on neuroprotection in a model of retinal ischemia. Exp Eye Res. 2017;154:116-125 pubmed publisher
    ..cannabinoids may also activate transient receptor potential (TRP) channels, we investigated the involvement of TRPA1 receptors (TRPA1) in retinal cell death induced by ischemic events...
  70. Oi Kano Y, Iwasaki Y, Nakamura T, Watanabe T, Goto T, Kawada T, et al. Oleuropein aglycone enhances UCP1 expression in brown adipose tissue in high-fat-diet-induced obese rats by activating ?-adrenergic signaling. J Nutr Biochem. 2017;40:209-218 pubmed publisher
    ..by examining the agonistic activity of oleuropein and OA toward the transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1)...
  71. Meents J, Fischer M, McNaughton P. Sensitization of TRPA1 by Protein Kinase A. PLoS ONE. 2017;12:e0170097 pubmed publisher
    The TRPA1 ion channel is expressed in nociceptive (pain-sensitive) somatosensory neurons and is activated by a wide variety of chemical irritants, such as acrolein in smoke or isothiocyanates in mustard...
  72. Gouin O, L Herondelle K, Lebonvallet N, Le Gall Ianotto C, Sakka M, Buhé V, et al. TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization. Protein Cell. 2017;8:644-661 pubmed publisher
    ..Transient receptor potential vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively) are non-selective cation channels known to specifically participate in pain and CNI...
  73. Roessingh S, Stanewsky R. The Drosophila TRPA1 Channel and Neuronal Circuits Controlling Rhythmic Behaviours and Sleep in Response to Environmental Temperature. Int J Mol Sci. 2017;18: pubmed publisher
    i>trpA1 encodes a thermosensitive transient receptor potential channel (TRP channel) that functions in selection of preferred temperatures and noxious heat avoidance...
  74. Tominaga M. [Activation and regulation of nociceptive transient receptor potential (TRP) channels, TRPV1 and TRPA1]. Yakugaku Zasshi. 2010;130:289-94 pubmed
    ..We found that alkaline pH activates TRPA1 and that the TRPA1 activation is involved in nociception, using Ca(2+)-imaging and patch-clamp methods...
  75. Alenmyr L, Herrmann A, Hogestatt E, Greiff L, Zygmunt P. TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo. Clin Physiol Funct Imaging. 2011;31:435-44 pubmed publisher
    ..were subjected to nasal challenges with TRPV1 agonists (capsaicin, olvanil and anandamide), TRP ankyrin 1 (TRPA1) agonists (cinnamaldehyde and mustard oil) and a TRP melastatin 8 (TRPM8) agonist (menthol)...
  76. Kim S, Barry D, Liu X, Yin S, Munanairi A, Meng Q, et al. Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations. Sci Signal. 2016;9:ra71 pubmed publisher
    ..TRPV1 responds to the itch-inducing endogenous signal histamine, and TRPA1 responds to the itch-inducing chemical chloroquine...
  77. Piao L, Fujita T, Yu T, Kumamoto E. Presynaptic facilitation by tetracaine of glutamatergic spontaneous excitatory transmission in the rat spinal substantia gelatinosa - Involvement of TRPA1 channels. Brain Res. 2017;1657:245-252 pubmed publisher
    The amide-type local anesthetic (LA) lidocaine activates transient receptor potential (TRP) ankyrin-1 (TRPA1) channels to facilitate spontaneous l-glutamate release onto spinal substantia gelatinosa (SG) neurons, which play a crucial ..
  78. Gil F, Giegling I, Reisch N, Hartmann A, Konte B, Schwarz M, et al. Association of somatoform disorder symptoms with genetic variants potentially involved in the modulation of nociception. Psychiatr Genet. 2011;21:50 pubmed publisher
  79. Andersen H, Gazerani P, Arendt Nielsen L. High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde. J Pain. 2016;17:919-29 pubmed publisher
    ..provoked by topical application of the transient receptor potential cation channel, subfamily A, member 1 (TRPA1) agonist trans-cinnamaldehyde (CA)...
  80. Sokabe T, Chen H, Luo J, Montell C. A Switch in Thermal Preference in Drosophila Larvae Depends on Multiple Rhodopsins. Cell Rep. 2016;17:336-344 pubmed publisher
    ..However, the Bolwig organ was dispensable for the thermal preference. Rather, Rh5 and Rh6 were required in trpA1-expressing neurons in the brain, ventral nerve cord, and body wall...
  81. Deering Rice C, Stockmann C, Romero E, Lu Z, Shapiro D, Stone B, et al. Characterization of Transient Receptor Potential Vanilloid-1 (TRPV1) Variant Activation by Coal Fly Ash Particles and Associations with Altered Transient Receptor Potential Ankyrin-1 (TRPA1) Expression and Asthma. J Biol Chem. 2016;291:24866-24879 pubmed
    ..This effect may be due in part to increased transient receptor potential ankyrin-1 (TRPA1) expression by lung epithelial cells expressing the TRPV1-I585V variant...
  82. Inui K, Chen C, Pauli J, Kuroki C, Tashiro S, Kanmura Y, et al. Nasal TRPA1 mediates irritant-induced bradypnea in mice. Physiol Rep. 2016;4: pubmed publisher
    Transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily, exists in sensory neurons such as trigeminal neurons innervating the nasal cavity and vagal neurons innervating the trachea and the lung...
  83. Ibarra Y, Blair N. Benzoquinone reveals a cysteine-dependent desensitization mechanism of TRPA1. Mol Pharmacol. 2013;83:1120-32 pubmed publisher
    The transient receptor potential ankyrin 1 (TRPA1) nonselective cation channel has a conserved function as a noxious chemical sensor throughout much of Metazoa...
  84. Oh M, Oh S, Lu J, Lou H, Myers A, Zhu Z, et al. TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis. J Immunol. 2013;191:5371-82 pubmed publisher
    ..Transient receptor potential ankyrin 1 (TRPA1) is essential in the signaling pathways that promote histamine-independent itch...
  85. Boukalova S, Touska F, Marsakova L, Hynkova A, Sura L, Chvojka S, et al. Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful?. Physiol Res. 2014;63 Suppl 1:S205-13 pubmed
    ..of some GOF mutants in polymodal ion channels specifically involved in transduction of painful stimuli--TRPV1 and TRPA1, which are scrutinized by scientists due to their important role in development of some pathological pain states...
  86. Jha A, Sharma P, Anaparti V, Ryu M, Halayko A. A role for transient receptor potential ankyrin 1 cation channel (TRPA1) in airway hyper-responsiveness?. Can J Physiol Pharmacol. 2015;93:171-6 pubmed publisher
    ..Recent research on ion channels, particularly transient receptor potential cation channel, subfamily A, member 1 (TRPA1), is uncovering new understanding of altered airway function...
  87. Witschas K, Jobin M, Korkut D, Vladan M, Salgado G, Lecomte S, et al. Interaction of a peptide derived from C-terminus of human TRPA1 channel with model membranes mimicking the inner leaflet of the plasma membrane. Biochim Biophys Acta. 2015;1848:1147-56 pubmed publisher
    The transient receptor potential ankyrin 1 channel (TRPA1) belongs to the TRP cation channel superfamily that responds to a panoply of stimuli such as changes in temperature, calcium levels, reactive oxygen and nitrogen species and lipid ..
  88. Brozmanova M, Mazurova L, Ru F, Tatar M, Hu Y, Yu S, et al. Mechanisms of the adenosine A2A receptor-induced sensitization of esophageal C fibers. Am J Physiol Gastrointest Liver Physiol. 2016;310:G215-23 pubmed publisher
    ..induces mechanical sensitization of esophageal C fibers by a mechanism involving transient receptor potential A1 (TRPA1)...
  89. Chepurny O, Holz G, Roe M, Leech C. GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion. Mol Endocrinol. 2016;30:614-29 pubmed publisher
    ..the STC-1 intestinal cell line by directly promoting Ca(2+) influx through transient receptor potential ankyrin 1 (TRPA1) cation channels...
  90. Castellanos A, Andres A, Bernal L, Callejo G, Comes N, Gual A, et al. Pyrethroids inhibit K2P channels and activate sensory neurons: basis of insecticide-induced paraesthesias. Pain. 2018;159:92-105 pubmed publisher
    ..we show that a high percentage of TM-responding neurons were nociceptors, which were also activated by TRPA1 and/or TRPV1 agonists...
  91. Oda M, Saito K, Hatta S, Kubo Y, Saitoh O. Chemical and thermal sensitivity of medaka TRPA1 analyzed in heterologous expression system. Biochem Biophys Res Commun. 2017;494:194-201 pubmed publisher
    b>TRPA1 of insects and several tetrapod vertebrates except for those of rodents have been reported to be activated by noxious chemicals and also by high temperature with a relatively clear threshold...
  92. Louhivuori L, Bart G, Larsson K, Louhivuori V, Näsman J, Nordström T, et al. Differentiation dependent expression of TRPA1 and TRPM8 channels in IMR-32 human neuroblastoma cells. J Cell Physiol. 2009;221:67-74 pubmed publisher
    b>TRPA1 and TRPM8 are transient receptor potential (TRP) channels involved in sensory perception. TRPA1 is a non-selective calcium permeable channel activated by irritants and proalgesic agents...