TRP 185


Gene Symbol: TRP 185
Description: TAR (HIV-1) RNA binding protein 1
Alias: TRM3, TRMT3, TRP-185, TRP185, TAR (HIV) RNA-binding protein 1, TAR RNA loop binding protein, TAR RNA-binding protein 1, TAR RNA-binding protein of 185 kDa, tRNA methyltransferase 3 homolog
Species: human
Products:     TRP 185

Top Publications

  1. Christensen H, Daher A, Soye K, Frankel L, Alexander M, Lainé S, et al. Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production. J Virol. 2007;81:5121-31 pubmed
    ..These results suggest that, in the context of HIV replication, TRBP contributes mainly to the enhancement of virus production and that Dicer does not mediate HIV restriction by RNAi. ..
  2. Freund I, Buhl D, Boutin S, Kötter A, Pichot F, Marchand V, et al. 2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms. RNA. 2019;: pubmed publisher
    ..Using RiboMethSeq analysis we show that mutation of trmH in E. coli, trm3 in S. cereviase and CRISPR/Cas9 induced knockout of TARBP1 in H. sapiens results in loss of Gm18 within tRNA...
  3. Takashima T, Ohnuma T, Fukamizo T. NMR analysis of substrate binding to a two-domain chitinase: Comparison between soluble and insoluble chitins. Carbohydr Res. 2018;458-459:52-59 pubmed publisher
    ..Based on the chemical shift perturbations of 1H-15N HSQC signals of Gly26 (CBM18 domain) and Trp185 (GH19 domain), the association constants for individual domains of CJP-4(E108Q) toward soluble chitin hexamer (..
  4. Zoued A, Duneau J, Durand E, España A, Journet L, Guerlesquin F, et al. Tryptophan-mediated Dimerization of the TssL Transmembrane Anchor Is Required for Type VI Secretion System Activity. J Mol Biol. 2018;430:987-1003 pubmed publisher
    ..NMR hydrogen-deuterium exchange experiments demonstrated the existence of a dimer with the presence of Trp185 and Trp199 at the interface...
  5. Monzel C, Unden G. Transmembrane signaling in the sensor kinase DcuS of Escherichia coli: A long-range piston-type displacement of transmembrane helix 2. Proc Natl Acad Sci U S A. 2015;112:11042-7 pubmed publisher
    ..Replacement of Trp 185 by an Arg residue caused displacement of TM2 toward the outside of the membrane and a concomitant induction of ..
  6. Ye J, Wang J, Tan L, Yang S, Xu L, Wu X, et al. Expression of protein TARBP1 in human hepatocellular carcinoma and its prognostic significance. Int J Clin Exp Pathol. 2015;8:9089-96 pubmed
    ..542-4.985; P=0.019). TARBP1 is up-regulated in HCC, and the expression of TARBP1 was associated with the pathological grading and clinical stage. TARBP1 maybe is an independent prognostic marker of HCC patients. ..
  7. Daniels S, Melendez Peña C, Scarborough R, Daher A, Christensen H, El Far M, et al. Characterization of the TRBP domain required for dicer interaction and function in RNA interference. BMC Mol Biol. 2009;10:38 pubmed publisher
    ..TRBPs, but not TRBPsDeltaC4, rescue RNAi activity in RNAi-compromised cells, indicating that the binding of Dicer to TRBP is critical for RNAi function. ..
  8. Wu Baer F, Lane W, Gaynor R. The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA. EMBO J. 1995;14:5995-6009 pubmed
    ..analysis indicated that only two cellular factors, RNA polymerase II and the previously characterized TAR RNA loop binding protein TRP-185, were capable of binding specifically to TAR RNA...
  9. Elsemman I, Mardinoglu A, Shoaie S, Soliman T, Nielsen J. Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism. Mol Biosyst. 2016;12:1496-506 pubmed publisher
    ..Finally, we confirmed our predictions with the results of metabolomics studies and proposed that inhibiting the identified targets has the potential to provide an effective treatment strategy for HCV-associated liver disorders...

More Information


  1. Beech R, Leffert J, Lin A, Hong K, Hansen J, Umlauf S, et al. Stress-related alcohol consumption in heavy drinkers correlates with expression of miR-10a, miR-21, and components of the TAR-RNA-binding protein-associated complex. Alcohol Clin Exp Res. 2014;38:2743-53 pubmed publisher
    ..Alterations in miRNA expression may be one mechanism linking psychological stress with changes in gene expression and increased alcohol intake in binge/HD. ..
  2. Clerzius G, Gélinas J, Gatignol A. Multiple levels of PKR inhibition during HIV-1 replication. Rev Med Virol. 2011;21:42-53 pubmed publisher
    ..Enhancing PKR activation by counteracting its inhibitory partners could establish an increased innate immune antiviral pathway against HIV-1 and could enhance the efficacy of the IFN treatment. ..
  3. Lin J, Xia J, Chen Y, Zhang K, Zeng Y, Yang Q. H9N2 avian influenza virus enhances the immune responses of BMDCs by down-regulating miR29c. Vaccine. 2017;35:729-737 pubmed publisher
    ..Together, our data shed new light on the roles and mechanisms of miR29c in regulating DC function and suggest new strategies for combating AIVs. ..
  4. Sand M, Skrygan M, Georgas D, Arenz C, Gambichler T, Sand D, et al. Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer. Mol Carcinog. 2012;51:916-22 pubmed publisher
    ..05). This study indicates that major components of the miRNA pathway, such as the microprocessor complex and RISC, are dysregulated in epithelial skin cancer. ..
  5. Seshadri S, Destefano A, Au R, Massaro J, Beiser A, Kelly Hayes M, et al. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. BMC Med Genet. 2007;8 Suppl 1:S15 pubmed
    ..These hypothesis generating data illustrate the use of an unbiased approach to discover novel pathways that may be involved in brain aging, and could be used to replicate observations made in other studies. ..
  6. Wu F, Garcia J, Sigman D, Gaynor R. tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185. Genes Dev. 1991;5:2128-40 pubmed
    ..These results characterize a positively acting cellular RNA-binding factor, TRP-185, which is involved in the regulation of HIV gene expression. ..
  7. Sheline C, Milocco L, Jones K. Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin. Genes Dev. 1991;5:2508-20 pubmed
    ..These findings suggest that the TAR element is recognized by two different nuclear RNA-binding proteins that affect transcriptional regulation by Tat. ..
  8. Wu H, Min J, Zeng H, Plotnikov A. Crystal structure of the methyltransferase domain of human TARBP1. Proteins. 2008;72:519-25 pubmed publisher
  9. Yedavalli V, Benkirane M, Jeang K. Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1. J Biol Chem. 2003;278:6404-10 pubmed
    ..Thus, like cellular promoters, HIV-1 LTR can use P-TEFb function without a Tat/TAR RNA complex. This activity could explain recent findings of robust HIV-1 replication in rat cells that cannot form a P-TEFb/Tat/TAR moiety. ..
  10. Wu Baer F, Lane W, Gaynor R. Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. J Biol Chem. 1996;271:4201-8 pubmed
    ..These studies define a group of cellular factors that function in concert to stimulate the binding of TRP-185 and RNA polymerase II to HIV-1 TAR RNA. ..
  11. Wu Baer F, Sigman D, Gaynor R. Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat. Proc Natl Acad Sci U S A. 1995;92:7153-7 pubmed
    ..These results suggest that Tat may function to alter RNA polymerase II, which is paused due to its binding to HIV-1 TAR RNA with resultant stimulation of its transcriptional elongation properties. ..