TrkB

Summary

Gene Symbol: TrkB
Description: neurotrophic receptor tyrosine kinase 2
Alias: EIEE58, GP145-TrkB, OBHD, TRKB, trk-B, BDNF/NT-3 growth factors receptor, BDNF-tropomyosine receptor kinase B, neurotrophic tyrosine kinase receptor type 2, tropomyosin-related kinase B, tyrosine kinase receptor B
Species: human
Products:     TrkB

Top Publications

  1. Yu Y, Zhang S, Wang X, Yang Z, Ou G. Overexpression of TrkB promotes the progression of colon cancer. APMIS. 2010;118:188-95 pubmed publisher
    Studies have confirmed that TrkB plays important roles in facilitating metastasis in various types of malignant tumors...
  2. Lai P, Chiu T, Huang Y. Overexpression of BDNF and TrkB in human bladder cancer specimens. Oncol Rep. 2010;24:1265-70 pubmed
    BDNF (brain-derived neurotrophic factor) and TrkB (tropomyosin receptor kinase B) are expressed in several tumor types...
  3. Xu K, Anderson T, Neyer K, Lamparella N, Jenkins G, Zhou Z, et al. Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence. Pharmacogenomics J. 2007;7:368-79 pubmed
    ..057). Taken together, these results support a role for the NTRK2 gene in addiction in a Caucasian population with AD and a subtype of ASPD. ..
  4. Okamura K, Harada T, Wang S, Ijichi K, Furuyama K, Koga T, et al. Expression of TrkB and BDNF is associated with poor prognosis in non-small cell lung cancer. Lung Cancer. 2012;78:100-6 pubmed publisher
    High expression levels of TrkB and BDNF are associated with aggressive malignant behavior in tumor cells and a poor prognosis in patients with various types of cancer...
  5. Huang Y, Lai P, Wu C, Hsu S, Cheng C, Lan Y, et al. BDNF mediated TrkB activation is a survival signal for transitional cell carcinoma cells. Int J Oncol. 2010;36:1469-76 pubmed
    ..Previously, brain-derived neurotrophic factor (BDNF) but not tropomyosin-related kinase B (TrkB) was found in normal urothelium...
  6. Gruber H, Ingram J, Hoelscher G, Zinchenko N, Norton H, Hanley E. Brain-derived neurotrophic factor and its receptor in the human and the sand rat intervertebral disc. Arthritis Res Ther. 2008;10:R82 pubmed publisher
    ..Our findings point to the need for further studies to define the role of BDNF in the human IVD and to investigate regulatory events within the disc that control the expression of BDNF and its receptor. ..
  7. Zhang Z, Han L, Liu Y, Liang X, Sun W. Up-regulation of Tropomyosin related kinase B contributes to resistance to detachment-induced apoptosis in hepatoma multicellular aggregations. Mol Biol Rep. 2009;36:1211-6 pubmed publisher
    ..Expression of TrkB on detached cells was much higher than that of attached ones...
  8. Lin E, Hong C, Hwang J, Liou Y, Yang C, Cheng D, et al. Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression. Rejuvenation Res. 2009;12:387-93 pubmed publisher
    ..Analyses using logistic regression models confirmed the gene-gene interactions. The results suggest that the BDNF and NTRK2 genes may contribute to the risk of geriatric depression independently and in an interactive manner. ..
  9. Nakagawara A, Liu X, Ikegaki N, White P, Yamashiro D, Nycum L, et al. Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2). Genomics. 1995;25:538-46 pubmed
    ..5-kb band encodes the full-length TRK-B mRNA and the 8.0-kb band encodes the truncated form of TRK-B mRNA. By fluorescence in situ hybridization and somatic cell hybrid mapping, the human TRK-B gene was localized to chromosome 9q22.1. ..

More Information

Publications63

  1. Arevalo J, Waite J, Rajagopal R, Beyna M, Chen Z, Lee F, et al. Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron. 2006;50:549-59 pubmed
    ..Unexpectedly, Nedd4-2 does not bind or ubiquitinate related TrkB receptors, due to the lack of a consensus PPXY motif...
  2. Bibel M, Hoppe E, Barde Y. Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR. EMBO J. 1999;18:616-22 pubmed
    ..Many cells co-express trk receptors and p75(NTR), and we found that p75(NTR) was co-precipitated with trkA, trkB and trkC in cells transfected with both receptor types...
  3. Douma S, van Laar T, Zevenhoven J, Meuwissen R, Van Garderen E, Peeper D. Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature. 2004;430:1034-9 pubmed
    ..Here, we report the identification of TrkB, a neurotrophic tyrosine kinase receptor, as a potent and specific suppressor of caspase-associated anoikis of non-..
  4. Luberg K, Wong J, Weickert C, Timmusk T. Human TrkB gene: novel alternative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development. J Neurochem. 2010;113:952-64 pubmed publisher
    ..Misregulation of TrkB has been reported in many human diseases, including cancer, obesity and neurological and psychiatric disorders...
  5. Au C, Siu M, Liao X, Wong E, Ngan H, Tam K, et al. Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome. Cancer Lett. 2009;281:151-61 pubmed publisher
    In this report, we demonstrated that overexpression of tropomyosin-related kinase B (TrkB) was associated with shorter survival in ovarian cancer patients...
  6. Reichardt L. Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci. 2006;361:1545-64 pubmed
    ..one or more of the three members of the tropomyosin-related kinase (Trk) family of receptor tyrosine kinases (TrkA, TrkB and TrkC)...
  7. Kupferman M, Jiffar T, el Naggar A, Yilmaz T, Zhou G, Xie T, et al. TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma. Oncogene. 2010;29:2047-59 pubmed publisher
    ..and here we present experimental evidence for a direct role of the cell surface receptor tyrosine kinase, TrkB, in HNSCC tumor progression...
  8. Akil H, Perraud A, Mélin C, Jauberteau M, Mathonnet M. Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival. PLoS ONE. 2011;6:e25097 pubmed publisher
    ..In parallel, CRC cells expressed high- (TrkB) and low-affinity (p75(NTR)) receptors at the plasma membrane, whereas TrkA and TrkC, two other high affinity ..
  9. Perez Pinera P, Hernandez T, Garcia Suarez O, de Carlos F, Germana A, del Valle M, et al. The Trk tyrosine kinase inhibitor K252a regulates growth of lung adenocarcinomas. Mol Cell Biochem. 2007;295:19-26 pubmed
    ..We showed that human lung adenocarcinomas express TrkA and TrkB, but not TrkC; A549 cells, derived from a human lung adenocarcinoma, express mRNA transcripts encoding nerve growth ..
  10. Thompson Ray M, Weickert C, Wyatt E, Webster M. Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders. J Psychiatry Neurosci. 2011;36:195-203 pubmed publisher
    Brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor (trkB-TK+) and glutamic acid decarboxylase (GAD67) mRNA levels have previously been found to be reduced in the prefrontal cortex of patients with schizophrenia...
  11. Bremer T, Diamond C, McKinney R, Shehktman T, Barrett T, Herold C, et al. The pharmacogenetics of lithium response depends upon clinical co-morbidity. Mol Diagn Ther. 2007;11:161-70 pubmed
    ..A test that could predict response to lithium based upon genetic factors would have significant clinical value...
  12. Bao W, Qiu H, Yang T, Luo X, Zhang H, Wan X. Upregulation of TrkB promotes epithelial-mesenchymal transition and anoikis resistance in endometrial carcinoma. PLoS ONE. 2013;8:e70616 pubmed publisher
    ..Recent data support a role for the cell surface receptor tyrosine kinase TrkB in the progression of several human tumors. Here we present evidence for a direct role of TrkB in human EC...
  13. Ernst C, Deleva V, Deng X, Sequeira A, Pomarenski A, Klempan T, et al. Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Arch Gen Psychiatry. 2009;66:22-32 pubmed publisher
    ..A truncated variant of the tropomyosin-related kinase B (TrkB.T1) is expressed in astrocytes, and brain-derived neurotrophic factor-TrkB signaling has been linked to mood ..
  14. Puehringer D, Orel N, Lüningschrör P, Subramanian N, Herrmann T, Chao M, et al. EGF transactivation of Trk receptors regulates the migration of newborn cortical neurons. Nat Neurosci. 2013;16:407-15 pubmed publisher
    ..We found that TrkB and TrkC, the receptors for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are activated by ..
  15. Qiu L, Zhou C, Sun Y, Di W, Scheffler E, Healey S, et al. Crosstalk between EGFR and TrkB enhances ovarian cancer cell migration and proliferation. Int J Oncol. 2006;29:1003-11 pubmed
    ..We investigated the crosstalk between EGFR and TrkB, both of which have been known to be important in cell survival and migration in response to EGF and BDNF...
  16. Kawamura N, Kawamura K, Manabe M, Tanaka T. Inhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growth. Endocrinology. 2010;151:3006-14 pubmed publisher
    ..Here, we found the expression of BDNF and neurtropin-4/5 together with TrkB in human trophoblastic choriocarcinoma cells...
  17. Fujikawa H, Tanaka K, Toiyama Y, Saigusa S, Inoue Y, Uchida K, et al. High TrkB expression levels are associated with poor prognosis and EMT induction in colorectal cancer cells. J Gastroenterol. 2012;47:775-84 pubmed publisher
    The neurotrophic receptor tropomyosin related kinase (TrkB) is associated with tumor progression in neuroblastoma and certain human malignancies. Recent reports indicate TrkB may participate in the epithelial-mesenchymal transition (EMT)...
  18. Zhang S, Guo D, Luo W, Zhang Q, Zhang Y, Li C, et al. TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells. BMC Cancer. 2010;10:43 pubmed publisher
    Aberrant regulation in the invasion of cancer cells is closely associated with their metastatic potentials. TrkB functions as a receptor tyrosine kinase and is considered to facilitate tumor metastasis...
  19. Geiger T, Peeper D. Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis. Cancer Res. 2007;67:6221-9 pubmed
    ..We have previously shown that the neurotrophic receptor tyrosine kinase TrkB suppresses anoikis in rat intestinal epithelial cells and renders them highly tumorigenic and metastatic...
  20. Alonso P, Gratacos M, Menchon J, Saiz Ruiz J, Segalas C, Baca Garcia E, et al. Extensive genotyping of the BDNF and NTRK2 genes define protective haplotypes against obsessive-compulsive disorder. Biol Psychiatry. 2008;63:619-28 pubmed
    ..LD)-mapping approach to investigate the role that BDNF and its specific receptor neurotrophic tyrosine kinase receptor type 2 (NTRK2) may play in increasing susceptibility to OCD...
  21. Esposito C, D Alessio A, de Franciscis V, Cerchia L. A cross-talk between TrkB and Ret tyrosine kinases receptors mediates neuroblastoma cells differentiation. PLoS ONE. 2008;3:e1643 pubmed publisher
    ..Retinoic acid (RA)-treatment of neuroblastoma (NB) cells implicates activation of Ret and TrkB RTKs as critical step to induce cell differentiation...
  22. Harada T, Yatabe Y, Takeshita M, Koga T, Yano T, Wang Y, et al. Role and relevance of TrkB mutations and expression in non-small cell lung cancer. Clin Cancer Res. 2011;17:2638-45 pubmed publisher
    b>TrkB has been involved in poor cancer outcome. TrkB mutations have been reported in non-small cell lung cancer...
  23. Romanczyk T, Weickert C, Webster M, Herman M, Akil M, Kleinman J. Alterations in trkB mRNA in the human prefrontal cortex throughout the lifespan. Eur J Neurosci. 2002;15:269-80 pubmed
    Signalling through tyrosine kinase receptor B (trkB) influences neuronal survival, differentiation and synaptogenesis...
  24. Stoilov P, Castren E, Stamm S. Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism. Biochem Biophys Res Commun. 2002;290:1054-65 pubmed
    We determined the gene structure of the human TrkB gene. The gene is unusually large and spans at least 590 kbp. It contains 24 exons...
  25. Sasahira T, Ueda N, Kurihara M, Matsushima S, Ohmori H, Fujii K, et al. Tropomyosin receptor kinases B and C are tumor progressive and metastatic marker in colorectal carcinoma. Hum Pathol. 2013;44:1098-106 pubmed publisher
    ..The role of Trks in cancer is still controversial. The expression and role of TrkB and TrkC were examined in colorectal cancer (CRC)...
  26. Hecht M, Schulte J, Eggert A, Wilting J, Schweigerer L. The neurotrophin receptor TrkB cooperates with c-Met in enhancing neuroblastoma invasiveness. Carcinogenesis. 2005;26:2105-15 pubmed
    ..However, amplification of the oncogene MYCN and expression of the neurotrophin receptor TrkB are known to contribute to a highly malignant phenotype...
  27. Hashimoto T, Bergen S, Nguyen Q, Xu B, Monteggia L, Pierri J, et al. Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J Neurosci. 2005;25:372-83 pubmed
    ..the involvement of signaling mediated by brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase TrkB in producing the altered GABA-related gene expression in schizophrenia...
  28. Geetha T, Wooten M. Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling. J Biol Chem. 2003;278:4730-9 pubmed
    ..Here we show that p62 interacts not only with TrkA but also with TrkB and TrkC, which are the primary receptors for brain-derived neurotrophic factor and neurotrophin-3...
  29. Ip N, Stitt T, Tapley P, Klein R, Glass D, Fandl J, et al. Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron. 1993;10:137-49 pubmed
    ..represents the functional counterpart of Xenopus neurotrophin-4 and is a "preferred" ligand for TrkB. However, its interactions with TrkB can be distinguished from those of brain-derived neurotrophic factor (BDNF) ..
  30. Banfield M, Naylor R, Robertson A, Allen S, Dawbarn D, Brady R. Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5. Structure. 2001;9:1191-9 pubmed
    ..7 A crystal structure of neurotrophin-4/5 bound to the neurotrophin binding domain of its high-affinity receptor TrkB (TrkB-d5)...
  31. Smith E, Bloss C, Badner J, Barrett T, Belmonte P, Berrettini W, et al. Genome-wide association study of bipolar disorder in European American and African American individuals. Mol Psychiatry. 2009;14:755-63 pubmed publisher
    ..3 (P=4.1 x 10(-6)), and rs7078071 in BTBD16 at 10q26.13 (P=4.5 x 10(-6)). This study is the first to conduct GWA of BD in individuals of AA and suggests that genetic variations that contribute to BD may vary as a function of ancestry. ..
  32. Dwivedi Y, Rizavi H, Conley R, Roberts R, Tamminga C, Pandey G. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry. 2003;60:804-15 pubmed
    ..BDNF), one of the most important neurotrophins, after binding with and activating receptor tyrosine kinase B (trk B), is directly involved in many physiological functions in the brain, including cell survival and synaptic ..
  33. Pearse R, Swendeman S, Li Y, Rafii D, Hempstead B. A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival. Blood. 2005;105:4429-36 pubmed
    ..member of the neurotrophin family of growth factors, and its high-affinity receptor, tropomyosin receptor kinase B (TrkB), contribute to these survival cues...
  34. Wong J, Rothmond D, Webster M, Weickert C. Increases in two truncated TrkB isoforms in the prefrontal cortex of people with schizophrenia. Schizophr Bull. 2013;39:130-40 pubmed publisher
    The truncated brain-derived neurotrophic factor (BDNF) receptors (truncated TrkB [TrkB-TK-] and sarc homology containing TrkB [TrkB-Shc]) are alternative transcripts of the full-length TrkB receptor (TrkB-TK+) that produce isoforms ..
  35. Pandya C, Kutiyanawalla A, Pillai A. BDNF-TrkB signaling and neuroprotection in schizophrenia. Asian J Psychiatr. 2013;6:22-8 pubmed publisher
    ..known to mediate its action through various intracellular signaling pathways triggered by activation of tyrosine kinase receptor B (TrkB)...
  36. Yilmaz T, Jiffar T, de la Garza G, Lin H, Milas Z, Takahashi Y, et al. Theraputic targeting of Trk supresses tumor proliferation and enhances cisplatin activity in HNSCC. Cancer Biol Ther. 2010;10:644-53 pubmed publisher
    ..Several lines of evidence support the role of TrkB for invasion and metastasis in various solid tumor models, and we have shown an important function of this receptor ..
  37. Hackett S, Friedman Z, Freund J, Schoenfeld C, Curtis R, DiStefano P, et al. A splice variant of trkB and brain-derived neurotrophic factor are co-expressed in retinal pigmented epithelial cells and promote differentiated characteristics. Brain Res. 1998;789:201-12 pubmed
    ..RT-PCR with primers spanning the transmembrane domain demonstrated that RPE cells express trkB mRNA lacking a region homologous to exon 9 of chicken trkB, a splice variant that has been demonstrated to ..
  38. Soontornniyomkij B, Everall I, Chana G, Tsuang M, Achim C, Soontornniyomkij V. Tyrosine kinase B protein expression is reduced in the cerebellum of patients with bipolar disorder. J Affect Disord. 2011;133:646-54 pubmed publisher
    ..Brain-derived neurotrophic factor (BDNF)-induced activation of tyrosine kinase B (TrkB) is essential to synaptic plasticity...
  39. Squinto S, Stitt T, Aldrich T, Davis S, Bianco S, Radziejewski C, et al. trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Cell. 1991;65:885-93 pubmed
    ..both BDNF and NT-3, but not NGF, bind to full-length and truncated forms of a receptor-like tyrosine kinase, trkB, for which no ligand had previously been identified...
  40. Yu X, Liu L, Cai B, He Y, Wan X. Suppression of anoikis by the neurotrophic receptor TrkB in human ovarian cancer. Cancer Sci. 2008;99:543-52 pubmed publisher
    b>TrkB is a neurotrophic tyrosine kinase receptor (Trk)...
  41. Marchetti A, Felicioni L, Pelosi G, Del Grammastro M, Fumagalli C, Sciarrotta M, et al. Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung. Hum Mutat. 2008;29:609-16 pubmed publisher
    ..Such mutational events could represent an important step in the cancerogenesis of these tumors and may have potential implications for the selection of patients for targeted therapy. ..
  42. Tanaka K, Mohri Y, Nishioka J, Kobayashi M, Ohi M, Miki C, et al. Neurotrophic receptor, tropomyosin-related kinase B as an independent prognostic marker in gastric cancer patients. J Surg Oncol. 2009;99:307-10 pubmed publisher
    Neurotrophic receptor tyrosine kinase TrkB has been associated with clinical outcome and chemotherapy resistance in neuroblastoma and certain human malignancies...
  43. Brodeur G, Minturn J, Ho R, Simpson A, Iyer R, Varela C, et al. Trk receptor expression and inhibition in neuroblastomas. Clin Cancer Res. 2009;15:3244-50 pubmed publisher
    ..In contrast, TrkB-expressing tumors frequently have MYCN amplification and are very aggressive and often fatal tumors...
  44. Minichiello L. TrkB signalling pathways in LTP and learning. Nat Rev Neurosci. 2009;10:850-60 pubmed publisher
    ..The receptor tyrosine kinase TrkB (also known as NTRK2), known primarily for its function during PNS and CNS development, has emerged in recent years ..
  45. Kohli M, Salyakina D, Pfennig A, Lucae S, Horstmann S, Menke A, et al. Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients. Arch Gen Psychiatry. 2010;67:348-59 pubmed publisher
    ..Our results suggest that a combination of several independent risk alleles within the NTRK2 locus is associated with SA in depressed patients, further supporting a role of neurotrophins in the pathophysiology of suicide. ..
  46. Iwasaki Y, Gay B, Wada K, Koizumi S. Association of the Src family tyrosine kinase Fyn with TrkB. J Neurochem. 1998;71:106-11 pubmed
    ..The Fyn-Src homology domain 2 (SH2) was observed to associate in vitro with the intracellular domain of TrkB (ICD-TrkB). This association was dependent on the autophosphorylation of ICD-TrkB...
  47. Li Z, Zhang Y, Wang Z, Chen J, Fan J, Guan Y, et al. The role of BDNF, NTRK2 gene and their interaction in development of treatment-resistant depression: data from multicenter, prospective, longitudinal clinic practice. J Psychiatr Res. 2013;47:8-14 pubmed publisher
    ..These results suggest that the interactions of BDNF (rs6265) with NTRK2 (rs1387923, rs2769605 and rs1565445) gene polymorphisms likely play an essential role in the development of TRD in Han Chinese MDD patients. ..
  48. Geiger T, Song J, Rosado A, Peeper D. Functional characterization of human cancer-derived TRKB mutations. PLoS ONE. 2011;6:e16871 pubmed publisher
    ..In human colorectal tumors, the neurotrophic receptor TRKB has been found mutated on two different sites in its kinase domain (TRKB(T695I) and TRKB(D751N))...
  49. Anger D, Zhang B, Boutross Tadross O, Foster W. Tyrosine receptor kinase B (TrkB) protein expression in the human endometrium. Endocrine. 2007;31:167-73 pubmed
    b>Tyrosine kinase receptor B (TrkB) gene expression, a neurotrophic factor receptor expressed in the brain and ovary, has recently been identified in deep infiltrating endometriosis by gene array...
  50. de Farias C, Heinen T, dos Santos R, Abujamra A, Schwartsmann G, Roesler R. BDNF/TrkB signaling protects HT-29 human colon cancer cells from EGFR inhibition. Biochem Biophys Res Commun. 2012;425:328-32 pubmed
    ..The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor TrkB have recently emerged as anticancer targets, and we have previously shown increased BDNF levels in CRC tumor ..
  51. Robinson K, Manto K, Buchsbaum R, MacDonald J, Meakin S. Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA. J Biol Chem. 2005;280:225-35 pubmed
    ..These studies identify RasGrf1 as a novel target of neurotrophin activation and suggest an additional pathway whereby neurotrophin-stimulated neurite outgrowth may be regulated. ..
  52. Hu Y, Wang Y, Guo T, Wei W, Sun C, Zhang L, et al. Identification of brain-derived neurotrophic factor as a novel angiogenic protein in multiple myeloma. Cancer Genet Cytogenet. 2007;178:1-10 pubmed
    ..The brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, TrkB, have been identified as critical factors in the regulation of vessel formation...
  53. Zhang Z, Hong J, Zhang S, Zhang T, Sha S, Yang R, et al. Postpartum estrogen withdrawal impairs hippocampal neurogenesis and causes depression- and anxiety-like behaviors in mice. Psychoneuroendocrinology. 2016;66:138-49 pubmed publisher
    ..The hippocampal BDNF levels were reduced in EW mice and OVX mice. TrkB receptor inhibitor K252a reduced the density of DCX(+) fibers in HSP mice without the reduction of 28-day-old BrdU(+..
  54. Zhao M, Ding S, Liu L, Wang Y, Zhang J, Zhang H, et al. [Predicative value of expression of TrkB and TRIM29 in biopsy tissues from preoperative gastroscopy in lymph node metastasis of gastric cancer]. Zhonghua Yi Xue Za Zhi. 2012;92:376-9 pubmed
    To analyze the expressions of TrkB and TRIM29 in biopsy tissues from preoperative gastroscopy in patients with gastric cancer and investigate the relationship between their expression and rate of lymph node metastasis...