TrkB

Summary

Gene Symbol: TrkB
Description: neurotrophic tyrosine kinase, receptor, type 2
Alias: GP145-TrkB, TRKB, trk-B, BDNF-tropomyosine receptor kinase B, BDNF/NT-3 growth factors receptor, trkB tyrosine kinase, tropomyosin-related kinase B, tyrosine kinase receptor B
Species: human

Top Publications

  1. ncbi TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma
    M E Kupferman
    Department of Head and Neck Surgery, Houston TX, USA
    Oncogene 29:2047-59. 2010
  2. ncbi Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
    Sirith Douma
    Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands
    Nature 430:1034-9. 2004
  3. ncbi Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Arch Gen Psychiatry 60:804-15. 2003
  4. ncbi Overexpression of BDNF and TrkB in human bladder cancer specimens
    Pei Chun Lai
    Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien 970, Taiwan, ROC
    Oncol Rep 24:1265-70. 2010
  5. ncbi Trk receptor expression and inhibition in neuroblastomas
    Garrett M Brodeur
    Division of Oncology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    Clin Cancer Res 15:3244-50. 2009
  6. ncbi A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival
    Roger N Pearse
    Division of Hematology, Cornell University Medical College, Rm C 606, 1300 York Ave, New York, NY 10021, USA
    Blood 105:4429-36. 2005
  7. ncbi Overexpression of TrkB promotes the progression of colon cancer
    Yingjiao Yu
    Department of Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, China
    APMIS 118:188-95. 2010
  8. ncbi Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome
    Christy W H Au
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Cancer Lett 281:151-61. 2009
  9. ncbi Inhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growth
    Nanami Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Endocrinology 151:3006-14. 2010
  10. ncbi Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients
    Martin A Kohli
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Arch Gen Psychiatry 67:348-59. 2010

Research Grants

  1. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Keqiang Ye; Fiscal Year: 2010
  2. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Keqiang Ye; Fiscal Year: 2010
  3. Brain-derived neurotrophic factor induced weight loss: neural mechanisms
    Chuanfeng Wang; Fiscal Year: 2010
  4. Brain-derived neurotrophic factor induced weight loss: neural mechanisms
    Chuanfeng Wang; Fiscal Year: 2009
  5. SYNAPTIC INTERACTIONS AND MECHANISMS IN THE RETINA
    DAVID RICHARD COPENHAGEN; Fiscal Year: 2010
  6. SYNAPTIC INTERACTIONS AND MECHANISMS IN THE RETINA
    David Copenhagen; Fiscal Year: 2009
  7. NEURAL CONTROL OF THE PREPUBERTAL OVARY
    Sergio R Ojeda; Fiscal Year: 2010
  8. NEURAL CONTROL OF THE PREPUBERTAL OVARY
    Sergio R Ojeda; Fiscal Year: 2010
  9. Antidepressants and Intracellular Signaling Linked to BDNF
    Lisa M Monteggia; Fiscal Year: 2010
  10. Neurotrophin receptor regulation of taste development
    Liliana Minichiello; Fiscal Year: 2010

Detail Information

Publications182 found, 100 shown here

  1. ncbi TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma
    M E Kupferman
    Department of Head and Neck Surgery, Houston TX, USA
    Oncogene 29:2047-59. 2010
    ..and here we present experimental evidence for a direct role of the cell surface receptor tyrosine kinase, TrkB, in HNSCC tumor progression...
  2. ncbi Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
    Sirith Douma
    Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands
    Nature 430:1034-9. 2004
    ..Here, we report the identification of TrkB, a neurotrophic tyrosine kinase receptor, as a potent and specific suppressor of caspase-associated anoikis of non-..
  3. ncbi Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Arch Gen Psychiatry 60:804-15. 2003
    ..BDNF), one of the most important neurotrophins, after binding with and activating receptor tyrosine kinase B (trk B), is directly involved in many physiological functions in the brain, including cell survival and synaptic ..
  4. ncbi Overexpression of BDNF and TrkB in human bladder cancer specimens
    Pei Chun Lai
    Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien 970, Taiwan, ROC
    Oncol Rep 24:1265-70. 2010
    BDNF (brain-derived neurotrophic factor) and TrkB (tropomyosin receptor kinase B) are expressed in several tumor types...
  5. ncbi Trk receptor expression and inhibition in neuroblastomas
    Garrett M Brodeur
    Division of Oncology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    Clin Cancer Res 15:3244-50. 2009
    ..In contrast, TrkB-expressing tumors frequently have MYCN amplification and are very aggressive and often fatal tumors...
  6. ncbi A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival
    Roger N Pearse
    Division of Hematology, Cornell University Medical College, Rm C 606, 1300 York Ave, New York, NY 10021, USA
    Blood 105:4429-36. 2005
    ..member of the neurotrophin family of growth factors, and its high-affinity receptor, tropomyosin receptor kinase B (TrkB), contribute to these survival cues...
  7. ncbi Overexpression of TrkB promotes the progression of colon cancer
    Yingjiao Yu
    Department of Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, China
    APMIS 118:188-95. 2010
    Studies have confirmed that TrkB plays important roles in facilitating metastasis in various types of malignant tumors...
  8. ncbi Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome
    Christy W H Au
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Cancer Lett 281:151-61. 2009
    In this report, we demonstrated that overexpression of tropomyosin-related kinase B (TrkB) was associated with shorter survival in ovarian cancer patients...
  9. ncbi Inhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growth
    Nanami Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Endocrinology 151:3006-14. 2010
    ..Here, we found the expression of BDNF and neurtropin-4/5 together with TrkB in human trophoblastic choriocarcinoma cells...
  10. ncbi Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients
    Martin A Kohli
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
    Arch Gen Psychiatry 67:348-59. 2010
    ..Especially in suicide victims, lower postmortem brain messenger RNA and protein levels of neurotrophins and their receptors have been reported...
  11. ncbi Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis
    Thomas R Geiger
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Cancer Res 67:6221-9. 2007
    ..We have previously shown that the neurotrophic receptor tyrosine kinase TrkB suppresses anoikis in rat intestinal epithelial cells and renders them highly tumorigenic and metastatic...
  12. ncbi A cross-talk between TrkB and Ret tyrosine kinases receptors mediates neuroblastoma cells differentiation
    Carla Lucia Esposito
    Istituto per l Endocrinologia e l Oncologia Sperimentale G Salvatore, Consiglio Nazionale delle Ricerche CNR, Naples, Italy
    PLoS ONE 3:e1643. 2008
    ..Retinoic acid (RA)-treatment of neuroblastoma (NB) cells implicates activation of Ret and TrkB RTKs as critical step to induce cell differentiation...
  13. ncbi Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression
    Eugene Lin
    Vita Genomics, Inc, Taipei, Taiwan
    Rejuvenation Res 12:387-93. 2009
    ..Analyses using logistic regression models confirmed the gene-gene interactions. The results suggest that the BDNF and NTRK2 genes may contribute to the risk of geriatric depression independently and in an interactive manner...
  14. ncbi Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung
    Antonio Marchetti
    Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    Hum Mutat 29:609-16. 2008
    ..Such mutational events could represent an important step in the cancerogenesis of these tumors and may have potential implications for the selection of patients for targeted therapy...
  15. ncbi TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells
    Siyang Zhang
    Center of Laboratory Technology and Experimental Medicine, China Medical University, Shenyang, China
    BMC Cancer 10:43. 2010
    Aberrant regulation in the invasion of cancer cells is closely associated with their metastatic potentials. TrkB functions as a receptor tyrosine kinase and is considered to facilitate tumor metastasis...
  16. ncbi BDNF mediated TrkB activation is a survival signal for transitional cell carcinoma cells
    Yen Ta Huang
    Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien 970, Taiwan, R O C
    Int J Oncol 36:1469-76. 2010
    ..Previously, brain-derived neurotrophic factor (BDNF) but not tropomyosin-related kinase B (TrkB) was found in normal urothelium...
  17. ncbi The Trk tyrosine kinase inhibitor K252a regulates growth of lung adenocarcinomas
    P Perez-Pinera
    Departamento de Morfologia y Biologia Celular, Facultad de Medicina, Universidad de Oviedo, Julian Claveria s n, Oviedo, Spain
    Mol Cell Biochem 295:19-26. 2007
    ..We showed that human lung adenocarcinomas express TrkA and TrkB, but not TrkC; A549 cells, derived from a human lung adenocarcinoma, express mRNA transcripts encoding nerve growth ..
  18. ncbi The neurotrophin receptor TrkB cooperates with c-Met in enhancing neuroblastoma invasiveness
    Monica Hecht
    Department of Pediatrics, University of Goettingen, Germany
    Carcinogenesis 26:2105-15. 2005
    ..However, amplification of the oncogene MYCN and expression of the neurotrophin receptor TrkB are known to contribute to a highly malignant phenotype...
  19. ncbi Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination
    Juan Carlos Arevalo
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology, and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Neuron 50:549-59. 2006
    ..Unexpectedly, Nedd4-2 does not bind or ubiquitinate related TrkB receptors, due to the lack of a consensus PPXY motif...
  20. ncbi Suppression of anoikis by the neurotrophic receptor TrkB in human ovarian cancer
    Xiaohui Yu
    Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated First People s Hospital, No 85 Wujin Road, Shanghai 200080, China
    Cancer Sci 99:543-52. 2008
    b>TrkB is a neurotrophic tyrosine kinase receptor (Trk)...
  21. ncbi Crosstalk between EGFR and TrkB enhances ovarian cancer cell migration and proliferation
    Lihua Qiu
    Department of Ob Gyn, Renji Hospital, Shanghai Jiaotong University, Shanghai 200001, P R China
    Int J Oncol 29:1003-11. 2006
    ..We investigated the crosstalk between EGFR and TrkB, both of which have been known to be important in cell survival and migration in response to EGF and BDNF...
  22. ncbi Identification of brain-derived neurotrophic factor as a novel angiogenic protein in multiple myeloma
    Yu Hu
    Institute of Hematology, Union Hospital, Tongji Medical College, Huanzhong University of Science and Technology, 1277 Jiefang Dadao, Wuhan 430022, P R China
    Cancer Genet Cytogenet 178:1-10. 2007
    ..The brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, TrkB, have been identified as critical factors in the regulation of vessel formation...
  23. ncbi Brain-derived neurotrophic factor and its receptor in the human and the sand rat intervertebral disc
    Helen E Gruber
    Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, NC 28232, USA
    Arthritis Res Ther 10:R82. 2008
    ....
  24. ncbi Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence
    K Xu
    Sections on Molecular Genetics and Human Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Pharmacogenomics J 7:368-79. 2007
    ..057). Taken together, these results support a role for the NTRK2 gene in addiction in a Caucasian population with AD and a subtype of ASPD...
  25. ncbi Extensive genotyping of the BDNF and NTRK2 genes define protective haplotypes against obsessive-compulsive disorder
    Pino Alonso
    OCD Clinical and Research Unit, Psychiatry Department, Hospital Universitari de Bellvitge, Barcelona, Spain
    Biol Psychiatry 63:619-28. 2008
    ..We used a linkage disequilibrium (LD)-mapping approach to investigate the role that BDNF and its specific receptor neurotrophic tyrosine kinase receptor type 2 (NTRK2) may play in increasing susceptibility to OCD...
  26. ncbi Up-regulation of Tropomyosin related kinase B contributes to resistance to detachment-induced apoptosis in hepatoma multicellular aggregations
    Zhiyong Zhang
    Institute of Immunology, Shandong University School of Medicine, Jinan, China
    Mol Biol Rep 36:1211-6. 2009
    ..Expression of TrkB on detached cells was much higher than that of attached ones...
  27. ncbi Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers
    Carl Ernst
    Departments ofNeurology and Neurosurgery, Douglas Hospital Research Institute, Montreal, QC H4H 1R3, Canada
    Arch Gen Psychiatry 66:22-32. 2009
    ..A truncated variant of the tropomyosin-related kinase B (TrkB.T1) is expressed in astrocytes, and brain-derived neurotrophic factor-TrkB signaling has been linked to mood ..
  28. ncbi Retrograde axonal transport obstruction of brain-derived neurotrophic factor (BDNF) and its TrkB receptor in the retina and optic nerve of American Cocker Spaniel dogs with spontaneous glaucoma
    Simone Iwabe
    Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, DF, Mexico
    Vet Ophthalmol 10:12-9. 2007
    ..optic nerve axonal transport obstruction at the scleral lamina cribosa level by examining levels of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor type B (TrkB) in dogs presenting with high intraocular pressure.
  29. ncbi Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat
    I Ferrer
    Unitat de Neuropatologia, Servei d Anatomia Patològica, Hospital Princeps d Espanya, Campus de Bellvitge, 08907 Hospitalet de Llobregat, Spain
    Acta Neuropathol 101:229-38. 2001
    ..we found: (1) a permanent reduction of brain-derived neurotrophic factor (BDNF) and its full-length receptor, TrkB, in the infarcted core; (2) a transient increase in BDNF immunoreactivity in the internal region of the border of ..
  30. ncbi Distribution of brain-derived neurotrophic factor and TrkB receptor proteins in the fetal and postnatal hippocampus and cerebellum of the guinea pig
    Sandra Dieni
    Department of Anatomy and Cell Biology, The University of Melbourne, Parkville, 3010 Victoria, Australia
    J Comp Neurol 454:229-40. 2002
    This study investigates the distribution of brain-derived neurotrophic factor protein (BDNF) and its receptor, TrkB, during the development of hippocampus and cerebellum in a long-gestation species, the guinea pig...
  31. ncbi Long-term locomotor training up-regulates TrkB(FL) receptor-like proteins, brain-derived neurotrophic factor, and neurotrophin 4 with different topographies of expression in oligodendroglia and neurons in the spinal cord
    Malgorzata Skup
    Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St 02 093 Warsaw, Poland
    Exp Neurol 176:289-307. 2002
    ..In particular, brain-derived neurotrophic factor (BDNF), acting through full-length TrkB receptor (TrkB(FL)), is implicated in the stimulation of neurotransmission...
  32. ncbi A novel trimeric peptide, Neuropep-1-stimulating brain-derived neurotrophic factor expression in rat brain improves spatial learning and memory as measured by the Y-maze and Morris water maze
    Min Kyoo Shin
    Biochemistry Laboratory, Department of Biological Science, Sungkyunkwan University, Jangan gu, Suwon, Gyeonggi Do, Korea
    J Neurochem 116:205-16. 2011
    ..Pre-treatment of TrkB inhibitor (K252a) did not block Neuropep-1-induced BDNF up-regulation...
  33. ncbi Continuous exposure to brain-derived neurotrophic factor is required for persistent activation of TrkB receptor, the ERK signaling pathway, and the induction of neuropeptide Y production in cortical cultures
    Ayalla Barnea
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9032, USA
    Brain Res 1020:106-17. 2004
    ..In some studies, it was shown that BDNF leads to the downregulation of TrkB receptor and some of its downstream responses, whereas in others it does not...
  34. ncbi Involvement of brain-derived neurotrophic factor (BDNF) in the functional elimination of synaptic contacts at polyinnervated neuromuscular synapses during development
    N Garcia
    Unitat d Histologia i Neurobiologia UHN, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Carrer Sant Llorenç, Spain
    J Neurosci Res 88:1406-19. 2010
    ..use immunohistochemistry to describe the localization of brain-derived neurotrophic factor (BDNF) and its receptors trkB and p75(NTR) in the neuromuscular synapses of postnatal rats (P6-P7) during the synapse elimination period...
  35. ncbi Immunolocalization of pro- and mature-brain derived neurotrophic factor (BDNF) and receptor TrkB in the human brainstem and hippocampus
    Samantha Tang
    Department of Paediatrics and Child Health, University of Sydney, NSW 2006, Australia
    Brain Res 1354:1-14. 2010
    Brain-derived neurotrophic factor (BDNF) and its receptor TrkB are essential in promoting normal development of the central nervous system...
  36. ncbi Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons
    Antonio Postigo
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Genes Dev 16:633-45. 2002
    Signaling by brain-derived neurotrophic factor (BDNF) via the TrkB receptor, or by neurotrophin-3 (NT3) through the TrkC receptor support distinct populations of sensory neurons...
  37. ncbi Neocortical neurons lacking the protein-tyrosine kinase B receptor display abnormal differentiation and process elongation in vitro and in vivo
    M A Gates
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroscience 98:437-47. 2000
    The spatial and temporal expression of the protein-tyrosine kinase B (TrkB) receptor and its ligands has been correlated with the development of the neocortex...
  38. ncbi Early postnatal ethanol exposure selectively decreases BDNF and truncated TrkB-T2 receptor mRNA expression in the rat cerebellum
    K E Light
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
    Brain Res Mol Brain Res 93:46-55. 2001
    ..We hypothesize that disruption of TrkB and/or TrkC mediated neurotrophin communication is, in part, responsible for the ethanol-induced loss of Purkinje ..
  39. ncbi A role for the neurotrophin receptor TrkB on maturing dendritic cells
    Kai Bratke
    Department of Pneumology, University of Rostock, Germany
    J Neuroimmunol 189:88-94. 2007
    ..Neurotrophins are involved in neuroimmune interactions. However, the expression and role of neurotrophin receptors on dendritic cells have not been systematically studied...
  40. ncbi An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study
    Marzena Mackowiak
    Eli Lilly and Co Ltd, Lilly Corporate Center, Indianapolis, IN 46285 0814, USA
    Neuropharmacology 43:1-10. 2002
    ..potentiator (LY404187) and its active isomer (LY451646) on the expression of BDNF protein and mRNA, as well as TrkB mRNA in rat hippocampus...
  41. ncbi Expression of brain-derived neurotrophic factor and tyrosine kinase B receptor proteins in glioneuronal tumors from patients with intractable epilepsy: colocalization with N-methyl-D-aspartic acid receptor
    E Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Acta Neuropathol 101:383-92. 2001
    Recent evidence suggests that brain-derived neurotrophic factor (BDNF) and its tyrosine kinase B (TrkB) receptor, in addition to promoting neuronal survival and differentiation, modulates synaptic transmission by increasing N-methyl-D-..
  42. ncbi Placental BDNF/TrkB signaling system is modulated by fetal growth disturbances in rat and human
    S Mayeur
    Univ Lille Nord de France, F 59000 Lille, France
    Placenta 31:785-91. 2010
    ..undernutrition (MU), during the perinatal life, modified both the BDNF and its functional receptor, the tyrosine kinase receptor B (TrkB) gene expression in the brain of growth-restricted rat offspring during sensitive developmental ..
  43. ncbi Theraputic targeting of Trk supresses tumor proliferation and enhances cisplatin activity in HNSCC
    Turker Yilmaz
    Department of Head and Neck Surgery, MD Anderson Cancer Center, University of Texas, Houston, TX, USA
    Cancer Biol Ther 10:644-53. 2010
    ..Several lines of evidence support the role of TrkB for invasion and metastasis in various solid tumor models, and we have shown an important function of this receptor ..
  44. ncbi Effects of trkB knockout on topography and ocular segregation of uncrossed retinal projections
    Jennifer Rodger
    Experimental and Regenerative Neurosciences, School of Animal Biology M317, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Exp Brain Res 195:35-44. 2009
    b>TrkB is an important receptor for brain-derived neurotrophic factor and NT4, members of the neurotrophin family. TrkB signaling is crucial in many activity-dependent and activity-independent processes of neural development...
  45. ncbi Cellular BRET assay suggests a conformational rearrangement of preformed TrkB/Shc complexes following BDNF-dependent activation
    Luc De Vries
    Department of Cellular and Molecular Biology, Institut de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81106 Castres, France
    Cell Signal 22:158-65. 2010
    We developed a cellular Bioluminescent Resonance Energy Transfer (BRET) assay based on the interaction of TrkB fused to Renilla luciferase with the intracellular adaptor protein Shc fused to Enhanced Yellow Fluorescent Protein (EYFP)...
  46. ncbi A positive change in energy balance modulates TrkB expression in the hypothalamus and nodose ganglia of rats
    Nadine Zeeni
    INRA, CNRH IdF, UMR914 Nutrition Physiology and Ingestive Behavior, AgroParisTech, 16 rue Claude Bernard, F 75005 Paris, France
    Brain Res 1289:49-55. 2009
    Brain-derived neurotrophic factor (BDNF) and its TrkB receptor play critical roles in the synaptic activity and plasticity of mature neurons and enhance adult neurogenesis...
  47. ncbi Gene dosage effect of the TrkB receptor on rod physiology and biochemistry in juvenile mouse retina
    B Rohrer
    Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, Charleston, SC 29425, USA
    Mol Vis 7:288-96. 2001
    To strengthen our understanding about the role of trkB in rod development by correlating functional and biochemical retinal phenotypes with levels of trkB expression in two independently created trkB transgenic lines.
  48. ncbi Locomotion induces changes in Trk B receptors in small diameter cells of the spinal cord
    M Skup
    Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland
    Acta Neurobiol Exp (Wars) 60:371. 2000
    ..If exercise enhances BDNF expression also in the spinal cord, upregulation of its receptor Trk B may occur. To verify this hypothesis we tested whether exercise influences TrkB receptor system in the spinal cord...
  49. ncbi The interaction between tropomyosin-related kinase B receptors and presynaptic muscarinic receptors modulates transmitter release in adult rodent motor nerve terminals
    Neus Garcia
    Unitat d Histologia i Neurobiologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, 43201 Reus, Spain
    J Neurosci 30:16514-22. 2010
    ..brain-derived neurotrophic factor (BDNF), neurotrophin-4 (NT-4) and the receptors tropomyosin-related kinase B (trkB) and p75(NTR) are present in the nerve terminals on the neuromuscular junctions (NMJs) of the levator auris longus ..
  50. ncbi Expression of TrkB in the murine kidney
    Olivia Garcia-Suarez
    Departamento de Morfologia y Biologia Celular, Universidad de Oviedo, Oviedo, and Servicio de Urologia, Hospital Clinico, Universidad de Valladolid, Spain
    Microsc Res Tech 69:1014-20. 2006
    ..study we used Western-blot and immunohistochemistry to investigate the occurrence and cellular localization of TrkB in the mouse kidney...
  51. ncbi Human TrkB gene: novel alternative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development
    Kristi Luberg
    Department of Gene Technology, Tallinn University of Technology, Tallinn, Estonia
    J Neurochem 113:952-64. 2010
    ..Misregulation of TrkB has been reported in many human diseases, including cancer, obesity and neurological and psychiatric disorders...
  52. ncbi Overexpression of the full-length neurotrophin receptor trkB regulates the expression of plasticity-related genes in mouse brain
    Eija Koponen
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Brain Res Mol Brain Res 130:81-94. 2004
    ..To specifically address the role of the trkB receptor, we have previously generated transgenic mice overexpressing the full-length trkB receptor and observed a ..
  53. ncbi Hippocampal mossy fiber sprouting and elevated trkB receptor expression following systemic administration of low dose domoic acid during neonatal development
    Paul B Bernard
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada
    Hippocampus 17:1121-33. 2007
    ..Herein we report further hippocampal changes, consisting of mossy fiber sprouting and associated changes in the trkB receptor population in young adult (3 months) rats, and further, report that these changes show regional variation ..
  54. ncbi Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling
    F F Eide
    Department of Neurology, University of Chicago, Illinois 60637, USA
    J Neurosci 16:3123-9. 1996
    b>trkB encodes a receptor tyrosine kinase activated by three neurotrophins--brain-derived neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4/5...
  55. ncbi Expression of TrkB receptor isoforms in the developing avian visual system
    A S Garner
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4975, USA
    J Neurosci 16:1740-52. 1996
    The expression of novel TrkB receptor transcripts has been characterized to understand the potentially diverse roles of brain-derived neurotrophic factor (BDNF) in the developing avian visual system...
  56. ncbi Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor
    Matthias Hartmann
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University Mainz, Duesbergweg 6, 55128 Mainz, Germany
    J Cell Sci 117:5803-14. 2004
    ..The neurotrophin BDNF and its cognate receptor tyrosine kinase, TrkB.FL, are highly expressed in neurons of the central nervous system...
  57. ncbi Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity
    J Gray
    Department of Clinical Biochemistry, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Int J Obes (Lond) 31:359-64. 2007
    The neurotrophin receptor TrkB has been implicated in the regulation of energy homeostasis in rodents...
  58. ncbi Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain
    Silvia Gines
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Casanova 143, E 08036 Barcelona, Spain
    Eur J Neurosci 23:649-58. 2006
    ..However, the effectiveness of BDNF may depend on the proper expression of its receptor TrkB. In this study, we analysed the expression of TrkB in several HD models and in postmortem HD brains...
  59. ncbi Role of accumbens BDNF and TrkB in cocaine-induced psychomotor sensitization, conditioned-place preference, and reinstatement in rats
    Amine Bahi
    Department of Psychiatry, Yale University School of Medicine, 301 Cedar Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 199:169-82. 2008
    ..BDNF action is mediated by the TrkB receptor-tyrosine kinase, and both BDNF and TrkB transcripts are widely expressed in the rat mesolimbic pathway, ..
  60. ncbi Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator of the TrkB neurotrophin receptor gene
    Lina K Martens
    Institut für Vegetative Physiologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Biol Chem 282:14379-88. 2007
    ..High expression levels of the neurotrophin receptor TrkB and its ligands in neuroblastomas are associated with an unfavorable outcome...
  61. ncbi Essential role of Hrs in endocytic recycling of full-length TrkB receptor but not its isoform TrkB.T1
    Shu Hong Huang
    Department of Neurobiology, Key Laboratory of Medical Neurobiology, School of Medicine, Jinan, Shandong 250012, China
    J Biol Chem 284:15126-36. 2009
    Brain-derived neurotrophic factor (BDNF) signaling through its receptor, TrkB, modulates survival, differentiation, and synaptic activity of neurons. Both full-length TrkB (TrkB-FL) and its isoform T1 (TrkB...
  62. ncbi Circadian variations in expression of the trkB receptor in adult rat hippocampus
    Claudia Dolci
    Dipartimento di Anatomia Umana, Universita di Milano, Via Mangiagalli 31, Milan I 20133, Italy
    Brain Res 994:67-72. 2003
    ..neurotrophic factor (BDNF) in the central nervous system (CNS) and the expression of its high-affinity trkB receptor on neuron surfaces are known to depend on neuron activity...
  63. ncbi Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus
    Michael H Donovan
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Hippocampus 18:435-9. 2008
    ..BDNF) is implicated in the regulation of adult hippocampal neurogenesis, presumably via its primary receptor, TrkB. However, controversy exists about how BDNF affects neurogenesis (e.g., proliferation vs. survival/differentiation)...
  64. ncbi [Expression of the neurotrophin-receptor TrkB predicts outcome in nephroblastomas: results of a pilot-study]
    A Eggert
    Universitätskinderklinik Essen, Abteilung für Hämatologie Onkologie, Germany
    Klin Padiatr 213:191-6. 2001
    The neurotrophin-receptor TrkB plays an important role in pathogenesis, biology and prognosis of neuroblastoma...
  65. ncbi Mechanism underlying activity-dependent insertion of TrkB into the neuronal surface
    Ling Zhao
    Department of Neurobiology, Key Laboratory of Medical Neurobiology, School of Medicine, Shandong University, Shandong, P R China
    J Cell Sci 122:3123-36. 2009
    Activity-dependent insertion of tyrosine kinase receptor type 2 (TrkB receptor) into the plasma membrane can explain, in part, the preferential effect of brain-derived neurotrophic factor (BDNF) on active neurons; however, the detailed ..
  66. ncbi TrkB signaling is required for behavioral sensitization and conditioned place preference induced by a single injection of cocaine
    Kristy R Crooks
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropharmacology 58:1067-77. 2010
    ..However, it is unclear whether BDNF signaling through the TrkB receptor can mediate these behavioral responses when animals are given a single cocaine exposure...
  67. ncbi Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus
    Xiao Ping He
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 22:7502-8. 2002
    Genetic and pharmacological perturbations suggest that tyrosine receptor kinase B (trkB) receptor activation promotes limbic epileptogenesis, but whether or where trkB activation occurs during epileptogenesis is uncertain...
  68. ncbi TrkB gene transfer does not alter hippocampal neuronal loss and cognitive deficits following traumatic brain injury in mice
    Valeria Conte
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
    Restor Neurol Neurosci 26:45-56. 2008
    ..Because TBI can result in decreased expression of the trkB receptor, thereby preventing BDNF from exerting potential neuroprotective effects, the contribution of both BDNF ..
  69. ncbi Regional- and age-dependent reduction in trkB receptor expression in the hippocampus is associated with altered spine morphologies
    Oliver Von Bohlen Und Halbach
    Department of Neuroanatomy, Interdisciplinary Center for Neurosciences, University of Heidelberg, Heidelberg, Germany
    Biol Psychiatry 59:793-800. 2006
    ..Decreased brain-derived neurotrophic factor (BDNF) levels seem to contribute to depression. Through its receptor trkB, BDNF is also involved in hippocampal LTP and hippocampus-dependent learning...
  70. ncbi Decreased neurotrophin TrkB receptor expression reduces lesion size in the apolipoprotein E-null mutant mouse
    Rosemary Kraemer
    Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Circulation 112:3644-53. 2005
    ..the Trk receptor tyrosine kinases, are potent chemotactic factors for smooth muscle cells, and the expression of brain-derived neurotrophic factor (BDNF) and its cognate receptor, TrkB, is upregulated in human atherosclerotic lesions.
  71. ncbi Regulation by nicotine of Gpr51 and Ntrk2 expression in various rat brain regions
    Dongxiao Sun
    Section of Neurobiology, Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22911, USA
    Neuropsychopharmacology 32:110-6. 2007
    ....
  72. ncbi Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro
    Mauricio G Martin
    VIB and Department of Human Genetics, Catholic University of Leuven, B 3000 Leuven, Belgium
    Mol Biol Cell 19:2101-12. 2008
    Binding of the neurotrophin brain-derived neurotrophic factor (BDNF) to the TrkB receptor is a major survival mechanism during embryonic development...
  73. ncbi Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx
    Jing Du
    Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892 4480, USA
    J Cell Biol 163:385-95. 2003
    ..Electric stimulation also potentiates TrkB tyrosine kinase activity...
  74. ncbi Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice
    Maxime Cazorla
    Neurobiology and Molecular Pharmacology, Centre de Psychiatrie et de Neurosciences, UMR 894 INSERM Université Paris Descartes, Paris, France
    PLoS ONE 5:e9777. 2010
    ..Numerous studies suggest that targeting BDNF and its TrkB receptor could be a promising therapeutic strategy for the treatment of brain disorders...
  75. ncbi Brain-derived neurotrophic factor effects on oligodendrocyte progenitors of the basal forebrain are mediated through trkB and the MAP kinase pathway
    Ashlee Van't Veer
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci Res 87:69-78. 2009
    ..increases the differentiation of basal forebrain (BF) oligodendrocytes (OLGs) in culture through the mediation of trkB and the MAPK pathway (Du et al. [ 2006a, b] Mol. Cell. Neurosci. 31:366-375; J. Neurosci. Res. 84:1692-1702)...
  76. ncbi A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
    Sung Wuk Jang
    Department of Pathology, Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:2687-92. 2010
    Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis...
  77. ncbi Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons
    A Meyer Franke
    Stanford University School of Medicine, Department of Neurobiology, California 94305, USA
    Neuron 21:681-93. 1998
    Here, we describe a novel mechanism for the rapid regulation of surface levels of the neurotrophin receptor TrkB. Unlike nodose ganglion neurons, both retinal ganglion cells (RGCs) and spinal motor neurons (SMNs) in culture display only ..
  78. ncbi Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival
    Hussein Akil
    Universite de Limoges, Laboratoire EA 3842, Homéostasie Cellulaire et Pathologies, Faculte de Medecine et de Pharmacie, Limoges, France
    PLoS ONE 6:e25097. 2011
    ..They were recently detected in some cancers in association with invasiveness, but the function of these tyrosine kinase receptors was not previously investigated in colorectal cancer (CRC) cells...
  79. ncbi Amyloid beta selectively modulates neuronal TrkB alternative transcript expression with implications for Alzheimer's disease
    J Wong
    Illawarra Health and Medical Research Institute, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia
    Neuroscience 210:363-74. 2012
    Dysregulation in brain-derived neurotrophic factor (BDNF)/full-length TrkB (TrkB-TK+) signaling is implicated in promoting neurodegeneration in Alzheimer's disease (AD)...
  80. ncbi A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome
    Danielle A Schmid
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 32:1803-10. 2012
    ..the hypotheses that BDNF deficits in Mecp2 mutants are associated with reduced activation of the BDNF receptor, TrkB, and that pharmacologic activation of TrkB would improve respiratory function...
  81. ncbi N-acetylserotonin activates TrkB receptor in a circadian rhythm
    Sung Wuk Jang
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:3876-81. 2010
    Brain-derived neurotrophic factor (BDNF) is a cognate ligand for the TrkB receptor. BDNF and serotonin often function in a cooperative manner to regulate neuronal plasticity, neurogenesis, and neuronal survival...
  82. ncbi Activation of adenosine A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts: implications for neuromodulation
    Natália Assaife-Lopes
    Institute of Pharmacology and Neuroscience, Faculty of Medicine, University of Lisbon, 1649 028 Lisbon, Portugal
    J Neurosci 30:8468-80. 2010
    ..Recruitment of TrkB receptors to lipid rafts has been shown to be necessary for the activation of specific signaling pathways and ..
  83. ncbi Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptor
    D S Middlemas
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186
    J Biol Chem 269:5458-66. 1994
    The TrkB receptor protein-tyrosine kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3...
  84. ncbi Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence
    Ming D Li
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 22911, USA
    Biol Psychiatry 64:951-7. 2008
    ....
  85. ncbi Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder
    Shiro Takei
    Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    J Psychiatr Res 45:460-8. 2011
    ..Brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine kinase receptor B (TrkB), are crucial for hippocampal-dependent learning and memory...
  86. ncbi Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice
    Yu Fan Liu
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
    Neurobiol Learn Mem 90:81-9. 2008
    ..for quantifying the hippocampal levels of brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB, the BDNF receptor), synaptotagmin (a Ca(2+)-dependent synaptic vesicle protein), and SNAP-25 (a presynaptic ..
  87. ncbi Brain-derived neurotrophic factor/TrkB signaling in memory processes
    Kiyofumi Yamada
    Laboratory of Experimental Therapeutics, Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920 0934, Japan
    J Pharmacol Sci 91:267-70. 2003
    ..and consolidation are associated with an increase in BDNF mRNA expression and the activation of its receptor TrkB. Genetic as well as pharmacologic deprivation of BDNF or TrkB impairs learning and memory...
  88. ncbi Characterization of trkB immunoreactive cells in the intermediolateral cell column of the rat spinal cord
    Annemarie M McCartney
    Center for Neuroscience and Behavior, Department of Zoology, Miami University, 280 Pearson Hall, Oxford, OH 45056, United States
    Neurosci Lett 440:103-8. 2008
    The objective of the present study was to characterize the trkB receptor immunoreactive (-ir) cells in the intermediolateral cell column (IML) of the upper thoracic spinal cord. Small trkB-ir cells (area=56.1+/-4...
  89. ncbi TrkB receptors are required for follicular growth and oocyte survival in the mammalian ovary
    Alfonso Paredes
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006 3448, USA
    Dev Biol 267:430-49. 2004
    ..We now report that neurotrophins (NTs) signaling via TrkB receptors are required for the growth of newly formed follicles...
  90. ncbi Increased truncated TrkB receptor expression and decreased BDNF/TrkB signaling in the frontal cortex of reeler mouse model of schizophrenia
    Anilkumar Pillai
    Department of Psychiatry and Health Behavior, Medical College of Georgia and Medical Research Service, Veterans Affairs Medical Center, Augusta, GA 30907, USA
    Schizophr Res 100:325-33. 2008
    ..BDNF, TrkB receptor isoforms (full-length and truncated), reelin, GAD67, GAD65, p75NTR, and NRH-2 levels were measured in the ..
  91. ncbi Brain-derived neurotrophic factor reduces TrkB protein and mRNA in the normal retina and following optic nerve crush in adult rats
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Ave, Memphis, TN 38163, USA
    Brain Res 1011:99-106. 2004
    ..These limitations might reflect either injury- or BDNF-induced retinal changes in TrkB, the high affinity tyrosine kinase receptor used by BDNF...
  92. ncbi Overexpression of tyrosine kinase B protein as a predictor for distant metastases and prognosis in gastric carcinoma
    Yong Zhang
    Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Oncology 75:17-26. 2008
    Tyrosine kinase B (TrkB) is associated with aggressive behavior and poor prognosis in various cancers. Here we examined the association between TrkB expression and distant metastases/prognosis in gastric carcinoma (GC).
  93. ncbi SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population
    Arianna Cozza
    Department of Experimental Pathology, Medical Biotechnology, Infectious Diseases and Epidemiology, University of Pisa, Pisa, Italy
    J Alzheimers Dis 15:61-70. 2008
    ..047). A trend to association with sAD and/or fAD was observed for other SNPs. Our results suggest that genetic variants of neurotrophin system genes might confer susceptibility to AD...
  94. ncbi [Effect of electroacupuncture of different acupoints on the excitability of detrusor muscle and the expression of BDNF and TrkB in the spinal cord of rats with urinary retention due to spinal cord injury]
    Jun Hua Wang
    Department of Rehabilitation of Taihe Hospital Affiliated to Yunyang Medical College, Shiyan 442000, China
    Zhen Ci Yan Jiu 34:387-92. 2009
    ..acupoints on the expression of brain-derived neurotrophic factor (BDNF) and tropomyosine receptor kinase B (TrkB) in the spinal cord and the excitability of detrusor muscle of the uninary bladder in rats with urinary retention ..
  95. ncbi Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina
    B Rohrer
    Howard Hughes Medical Institute, School of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    J Neurosci 19:8919-30. 1999
    Brain-derived neurotrophic factor (BDNF) acts through TrkB, a receptor with kinase activity, and mitigates light-induced apoptosis in adult mouse rod photoreceptors...
  96. ncbi Neurotrophic effect of a novel TrkB agonist on retinal ganglion cells
    Ying Hu
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 51:1747-54. 2010
    ..Recently, novel tropomyosin-related kinase B (TrkB) monoclonal antibodies have been shown to activate TrkB receptors and exert neuroprotective and neurotrophic ..
  97. ncbi TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections
    A Martinez
    Department of Animal and Plant Cell Biology, University of Barcelona, Barcelona 08028, Spain
    J Neurosci 18:7336-50. 1998
    ..in the development of neural connections in the CNS, we studied the ontogeny of hippocampal afferents in trkB (-/-) and trkC (-/-) mice...
  98. ncbi Co-infusion with a TrkB-Fc receptor body carrier enhances BDNF distribution in the adult rat brain
    S D Croll
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, New York, 10591, USA
    Exp Neurol 152:20-33. 1998
    ..We have generated a fusion protein using the ectodomain of TrkB (TrkB-Fc)...
  99. ncbi Neonatal maternal separation increases brain-derived neurotrophic factor and tyrosine kinase receptor B expression in the descending pain modulatory system
    Elaine K Y Chung
    School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, SAR, China
    Neurosignals 17:213-21. 2009
    ..The present study aimed to investigate changes in the expression of BDNF and its receptor tyrosine kinase receptor B (TrkB) in the amygdala and the rostral ventromedial medulla (RVM) after NMS and colorectal distention (..
  100. ncbi Identification and structure of the nerve growth factor binding site on TrkA
    A G Robertson
    Molecular Neurobiology Unit, URCN, Bristol, BS2 8HW, United Kingdom
    Biochem Biophys Res Commun 282:131-41. 2001
    ..We also present the three-dimensional structure of the TrkAIg(2) domain in a new crystal form, refined to 2.0 A resolution...
  101. ncbi TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain
    Xidao Wang
    Department of Anatomy and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 29:5508-15. 2009
    ..a chemical-genetic and pharmacological approach to study the contribution of the receptor tyrosine kinase, type 2 (TrkB) to the generation and maintenance of injury-induced persistent pain...

Research Grants71

  1. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Keqiang Ye; Fiscal Year: 2010
    ..These compounds readily crossed the blood brain barrier and into the cochlea. They activated TrkB receptors at extremely low concentrations...
  2. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Keqiang Ye; Fiscal Year: 2010
    ..These compounds readily crossed the blood brain barrier and into the cochlea. They activated TrkB receptors at extremely low concentrations...
  3. Brain-derived neurotrophic factor induced weight loss: neural mechanisms
    Chuanfeng Wang; Fiscal Year: 2010
    ..Our preliminary data on potential mechanisms of BDNF effects indicate that: 1) blockade of BDNF binding to TrkB receptor attenuates BDNF-inhibited feeding;2) blockade of CRH receptor (CRHR) signaling attenuates BDNF-inhibited ..
  4. Brain-derived neurotrophic factor induced weight loss: neural mechanisms
    Chuanfeng Wang; Fiscal Year: 2009
    ..Our preliminary data on potential mechanisms of BDNF effects indicate that: 1) blockade of BDNF binding to TrkB receptor attenuates BDNF-inhibited feeding; 2) blockade of CRH receptor (CRHR) signaling attenuates BDNF-inhibited ..
  5. SYNAPTIC INTERACTIONS AND MECHANISMS IN THE RETINA
    DAVID RICHARD COPENHAGEN; Fiscal Year: 2010
    ..Factor) is down regulated by visual deprivation and it plays a critical role, through activation of the TrkB receptor, in governing the refinement of more diffuse dendritic arbors of ON-OFF type ganglion cells into more ..
  6. SYNAPTIC INTERACTIONS AND MECHANISMS IN THE RETINA
    David Copenhagen; Fiscal Year: 2009
    ..Factor) is down regulated by visual deprivation and it plays a critical role, through activation of the TrkB receptor, in governing the refinement of more diffuse dendritic arbors of ON-OFF type ganglion cells into more ..
  7. NEURAL CONTROL OF THE PREPUBERTAL OVARY
    Sergio R Ojeda; Fiscal Year: 2010
    ..Employing gene targeting approaches we identified trkB, the high-affinity receptor for neurotrophin-4/5 (NT-4/5) and brain-derived neurotrophic factor (BDNF), as a ..
  8. NEURAL CONTROL OF THE PREPUBERTAL OVARY
    Sergio R Ojeda; Fiscal Year: 2010
    ..Employing gene targeting approaches we identified trkB, the high-affinity receptor for neurotrophin-4/5 (NT-4/5) and brain-derived neurotrophic factor (BDNF), as a ..
  9. Antidepressants and Intracellular Signaling Linked to BDNF
    Lisa M Monteggia; Fiscal Year: 2010
    ..neurotrophic factor (BDNF) is the most prevalent neurotrophin in brain;via actions on its high affinity trkB receptor it enhances the survival of many types of central neurons and is implicated in several forms of neural ..
  10. Neurotrophin receptor regulation of taste development
    Liliana Minichiello; Fiscal Year: 2010
    ..two neurotrophins, BDNF and NT4, can influence various aspects of neural innervation through the same receptors, TrkB and p75...
  11. ROLE OF BDNF IN THE PHOTIC CONTROL OF CIRCADIAN RHYTHMS
    David Earnest; Fiscal Year: 2003
    ..whether retinohypothalamic tract (RHT) fibers innervating the SCN or cells receiving RHT input express TrkB tyrosine kinase receptors, the cognate receptor for BDNF, using imunochistochemical and tract tracing methods and whether ..
  12. A universal photoswitch system for optical control of neuronal receptors
    Richard H Kramer; Fiscal Year: 2010
    ..We will test the effectiveness of the Universal Photoswitch approach on two example receptors: the TrkB receptor for brain-derived growth factor (BDNF), a member of the neurotrophin family of receptor tyrosine kinases, ..
  13. Recovery of Respiratory Function After Spinal Cord Injury
    GARY C contact SIECK; Fiscal Year: 2010
    ..g., brain- derived neurotrophic factor - BDNF) acting through tropomyosin related kinase receptors (e.g., TrkB) play an important role in neuroplasticity...
  14. CELL/CELL INTERACTIONS IN CEREBELLAR DEVELOPMENT
    Rosalind Segal; Fiscal Year: 2001
    ..Specific aim 2 is to test the hypothesis that both TrkB and the p75 receptor mediate the effects of BDNF in developing Purkinje cells...
  15. Influence of Innervation on Diaphragm Muscle Growth
    Gary Sieck; Fiscal Year: 2007
    ..mechanisms regulating MHC protein expression during postnatal growth of DIAm fibers, 2) to explore the effects of TrkB receptor activation on MHC protein expression, 3) to explore the effects of DNV (i.e...
  16. Neonatal Modulation of Airway Contractility
    RICHARD JOHN MARTIN; Fiscal Year: 2010
    ..that ASM from hyperoxia-exposed rat pups exhibits increased expression of BDNF together with its high affinity TrkB receptor at both message and protein levels...
  17. Neonatal Modulation of Airway Contractility
    Richard Martin; Fiscal Year: 2009
    ..that ASM from hyperoxia-exposed rat pups exhibits increased expression of BDNF together with its high affinity TrkB receptor at both message and protein levels...
  18. Visualizing synaptic circuitry in the retina
    Xandra Breakefield; Fiscal Year: 2006
    ..virion will be replaced with BDNF to increase infection of retinal ganglion cells that express high levels of the TrkB receptor on their cell surface...
  19. TrkB & Synapse Elimination in the Developing Cerebellum
    Erin Johnson; Fiscal Year: 2007
    ..on investigating the maturation of the climbing fiber-Purkinje cell synapse and to test the hypothesis that the TrkB receptor plays a role in regulating the switch from multiple to single climbing fiber innervation of Purkinje cells ..
  20. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2009
    ..use human ASM and the ovalbumin (OVA) mouse model to examine the relative role of the BDNF receptors (high affinity TrkB vs. low affinity p75NTR) vis-vis ASM contractility...
  21. MECHANISMS OF INCONTINENCE FOLLOWING VAGINAL DISTENSION
    Margot S Damaser; Fiscal Year: 2010
    ..to determine the time course and extent of changes in local blood flow, tissue hypoxia, NMJs, and BDNF, NT-4, and trkB (the receptor for both BDNF and NT-4) expression in the genitourinary organs due to vaginal distensions of ..
  22. MECHANISMS OF INCONTINENCE FOLLOWING VAGINAL DISTENSION
    Margot Damaser; Fiscal Year: 2007
    ..to determine the time course and extent of changes in local blood flow, tissue hypoxia, NMJs, and BDNF, NT-4, and trkB (the receptor for both BDNF and NT-4) expression in the genitourinary organs due to vaginal distensions of ..
  23. MECHANISMS OF INCONTINENCE FOLLOWING VAGINAL DISTENSION
    Margot Damaser; Fiscal Year: 2009
    ..to determine the time course and extent of changes in local blood flow, tissue hypoxia, NMJs, and BDNF, NT-4, and trkB (the receptor for both BDNF and NT-4) expression in the genitourinary organs due to vaginal distensions of ..
  24. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2010
    ..use human ASM and the ovalbumin (OVA) mouse model to examine the relative role of the BDNF receptors (high affinity TrkB vs. low affinity p75NTR) vis-vis ASM contractility...
  25. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2009
    ..use human ASM and the ovalbumin (OVA) mouse model to examine the relative role of the BDNF receptors (high affinity TrkB vs. low affinity p75NTR) vis-vis ASM contractility...
  26. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2009
    ..to increased expression of brain-derived neurotrophic factor (BDNF) in colonic afferents and increases in BDNF and TrkB in bladder afferent neurons...
  27. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2010
    ..to increased expression of brain-derived neurotrophic factor (BDNF) in colonic afferents and increases in BDNF and TrkB in bladder afferent neurons...