trkA

Summary

Gene Symbol: trkA
Description: neurotrophic receptor tyrosine kinase 1
Alias: MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, high affinity nerve growth factor receptor, Oncogene TRK, TRK1-transforming tyrosine kinase protein, gp140trk, neurotrophic tyrosine kinase, receptor, type 1, tropomyosin-related kinase A, tyrosine kinase receptor A
Species: human
Products:     trkA

Top Publications

  1. Martin Zanca D, Hughes S, Barbacid M. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature. 1986;319:743-8 pubmed
  2. Schulte J, Schramm A, Klein Hitpass L, Klenk M, Wessels H, Hauffa B, et al. Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas. Oncogene. 2005;24:165-77 pubmed
    ..High expression of TrkA (NTRK1) is associated with a favorable biology and outcome of neuroblastoma, whereas TrkB (NTRK2) is expressed on ..
  3. Tacconelli A, Farina A, Cappabianca L, Desantis G, Tessitore A, Vetuschi A, et al. TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma. Cancer Cell. 2004;6:347-60 pubmed
    We identify a novel alternative TrkA splice variant, TrkAIII, with deletion of exons 6, 7, and 9 and functional extracellular IG-C1 and N-glycosylation domains, that exhibits expression restricted to undifferentiated early neural ..
  4. Lagadec C, Meignan S, Adriaenssens E, Foveau B, Vanhecke E, Romon R, et al. TrkA overexpression enhances growth and metastasis of breast cancer cells. Oncogene. 2009;28:1960-70 pubmed publisher
    ..Here, we show that breast tumors present high levels of TrkA and phospho-TrkA compared to normal breast tissues...
  5. Houlden H, King R, Hashemi Nejad A, Wood N, Mathias C, Reilly M, et al. A novel TRK A (NTRK1) mutation associated with hereditary sensory and autonomic neuropathy type V. Ann Neurol. 2001;49:521-5 pubmed
    ..DNA analysis showed that he was homozygous for a mutation in the NTRK1/high-affinity nerve growth factor (TrkA) gene, his parents being heterozygous...
  6. Martin Zanca D, Oskam R, Mitra G, Copeland T, Barbacid M. Molecular and biochemical characterization of the human trk proto-oncogene. Mol Cell Biol. 1989;9:24-33 pubmed
    Molecular analysis of the human trk oncogene, a transforming gene isolated from a colon carcinoma biopsy, revealed the existence of a novel member of the tyrosine kinase gene family...
  7. Bertrand T, Kothe M, Liu J, Dupuy A, Rak A, Berne P, et al. The crystal structures of TrkA and TrkB suggest key regions for achieving selective inhibition. J Mol Biol. 2012;423:439-53 pubmed publisher
    The Trk family of neurotrophin receptors, which includes the three highly homologous proteins TrkA, TrkB and TrkC, is strongly associated with central and peripheral nervous system processes...
  8. Miranda C, Greco A, Miele C, Pierotti M, Van Obberghen E. IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1. J Cell Physiol. 2001;186:35-46 pubmed
    TRK-T1 oncogene is generated by the rearrangement of the NGF receptor TrkA with TPR. This gives rise to the constitutive tyrosine autophosphorylation and activation of the kinase...
  9. Greco A, Pierotti M, Bongarzone I, Pagliardini S, Lanzi C, Della Porta G. TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. Oncogene. 1992;7:237-42 pubmed
    We have recently reported the frequent activation of the TRK oncogene in human papillary thyroid carcinoma. In this paper we describe the isolation and characterization of one of the thyroid TRK oncogenes, designated TRK-T1...

More Information

Publications85

  1. Farina A, Tacconelli A, Cappabianca L, Cea G, Panella S, Chioda A, et al. The alternative TrkAIII splice variant targets the centrosome and promotes genetic instability. Mol Cell Biol. 2009;29:4812-30 pubmed publisher
  2. Barker P, Lomen Hoerth C, Gensch E, Meakin S, Glass D, Shooter E. Tissue-specific alternative splicing generates two isoforms of the trkA receptor. J Biol Chem. 1993;268:15150-7 pubmed
    The trkA receptor functions as a signal transducing receptor for nerve growth factor. In this report, we show that alternative splicing results in the production of two distinct trkA isoforms in both rats and humans...
  3. Meakin S, MacDonald J, Gryz E, Kubu C, Verdi J. The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. J Biol Chem. 1999;274:9861-70 pubmed
    ..kinase substrate p13(suc1), and the Src homology 3 (SH3) domain of Src, providing a functional link between TrkA, cell cycle, and multiple NGF signaling effectors...
  4. MacDonald J, Gryz E, Kubu C, Verdi J, Meakin S. Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA. J Biol Chem. 2000;275:18225-33 pubmed
    We demonstrate that the signaling adapter, Grb2, binds directly to the neurotrophin receptor tyrosine kinase, TrkA. Grb2 binding to TrkA is independent of Shc, FRS-2, phospholipase Cgamma-1, rAPS, and SH2B and is observed in in vitro ..
  5. Wooten M, Seibenhener M, Mamidipudi V, Diaz Meco M, Barker P, Moscat J. The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. J Biol Chem. 2001;276:7709-12 pubmed
    Nerve growth factor (NGF) binding to both p75 and TrkA neurotrophin receptors activates the transcription factor nuclear factor kappaB (NF-kappaB)...
  6. Indo Y, Mardy S, Miura Y, Moosa A, Ismail E, Toscano E, et al. Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency. Hum Mutat. 2001;18:308-18 pubmed
    ..The human TRKA gene (NTRK1), located on chromosome 1q21-q22 encodes the receptor tyrosine kinase for nerve growth factor...
  7. Zhang Z, Yang Y, Gong A, Wang C, Liang Y, Chen Y. Localization of NGF and TrkA at mitotic apparatus in human glioma cell line U251. Biochem Biophys Res Commun. 2005;337:68-74 pubmed
    It has previously been implicated that nerve growth factor (NGF) with its high-affinity receptor tyrosine kinase A (TrkA) could play an important role in the growth modulation of human tumor cells, such as glioblastoma multiform cell ..
  8. Brodeur G, Minturn J, Ho R, Simpson A, Iyer R, Varela C, et al. Trk receptor expression and inhibition in neuroblastomas. Clin Cancer Res. 2009;15:3244-50 pubmed publisher
    ..Neuroblastomas expressing TrkA are biologically favorable and prone to spontaneous regression or differentiation, depending on the absence or ..
  9. Gimm O, Greco A, Hoang Vu C, Dralle H, Pierotti M, Eng C. Mutation analysis reveals novel sequence variants in NTRK1 in sporadic human medullary thyroid carcinoma. J Clin Endocrinol Metab. 1999;84:2784-7 pubmed
    ..pathogenesis of PTC, the obvious parallels between RET and NTRK1 and between PTC and medullary thyroid carcinoma (MTC), NTRK1 seemed to be an excellent candidate gene to play a role in the genesis of MTC...
  10. Liu D, Zhang Y, Dang C, Ma Q, Lee W, Chen W. siRNA directed against TrkA sensitizes human pancreatic cancer cells to apoptosis induced by gemcitabine through an inactivation of PI3K/Akt-dependent pathway. Oncol Rep. 2007;18:673-7 pubmed
    ..may be due to the aberrant expression of nerve growth factor (NGF) and its high-affinity receptor, proto-oncogene TrkA. In this study, we sought to determine the effect of suppressing TrkA expression on pancreatic cancer ..
  11. Brahimi F, Liu J, Malakhov A, Chowdhury S, Purisima E, Ivanisevic L, et al. A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist. Biochim Biophys Acta. 2010;1800:1018-26 pubmed publisher
    ..our report of a small molecule monovalent ligand "D3" that is a partial agonist of the NGF receptor TrkA. A bivalent "D3-linker-D3" was expected to increase agonism...
  12. Ong S, Guy G, Hadari Y, Laks S, Gotoh N, Schlessinger J, et al. FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. Mol Cell Biol. 2000;20:979-89 pubmed
    ..interacts with FRS2 constitutively, independent of ligand stimulation and tyrosine phosphorylation, NGF receptor (TrkA) binding to FRS2 is strongly dependent on receptor activation...
  13. Wu C, Lai C, Mobley W. Nerve growth factor activates persistent Rap1 signaling in endosomes. J Neurosci. 2001;21:5406-16 pubmed
    ..NGF induced the formation of a long-lived complex containing C3G/CrkL/Shp2/Gab2/TrkA. Linking the complex to Rap1 activation, we coprecipitated activated TrkA and activated MAPK with activated Rap1 in ..
  14. Indo Y. Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve gr. Clin Auton Res. 2002;12 Suppl 1:I20-32 pubmed
    ..The human TRKA (NTRKI) gene located on chromosome 1 (1q21-q22) encodes a receptor tyrosine kinase (RTK) which is ..
  15. Tomasson M, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T, et al. Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. Blood. 2008;111:4797-808 pubmed publisher
    ..Additional studies will be required to define the roles that these somatic and germline TK gene variants play in AML pathogenesis. ..
  16. Greco A, Mariani C, Miranda C, Lupas A, Pagliardini S, Pomati M, et al. The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. Mol Cell Biol. 1995;15:6118-27 pubmed
    Oncogenic rearrangements of the NTRK1 gene (also designated TRKA), encoding one of the receptors for the nerve growth factor, are frequently detected in thyroid carcinomas...
  17. Com E, Lagadec C, Page A, El Yazidi Belkoura I, Slomianny C, Spencer A, et al. Nerve growth factor receptor TrkA signaling in breast cancer cells involves Ku70 to prevent apoptosis. Mol Cell Proteomics. 2007;6:1842-54 pubmed
    The nerve growth factor (NGF)-tyrosine kinase receptor TrkA plays a critical role in various neuronal and non-neuronal cell types by regulating cell survival, differentiation, and proliferation...
  18. Yamashita H, Avraham S, Jiang S, Dikic I, Avraham H. The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells. J Biol Chem. 1999;274:15059-65 pubmed
    ..Using PC12 cells as a model system of neuronal cells, we show that CHK participates in signaling mediated by TrkA receptors...
  19. Indo Y, Tsuruta M, Hayashida Y, Karim M, Ohta K, Kawano T, et al. Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. Nat Genet. 1996;13:485-8 pubmed
    ..Mice lacking the gene for TrkA, a receptor tyrosine kinase for NGF, share dramatic phenotypic features of CIPA, including loss of responses to ..
  20. Stephens R, Loeb D, Copeland T, Pawson T, Greene L, Kaplan D. Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses. Neuron. 1994;12:691-705 pubmed
    In response to NGF, the Trk receptor tyrosine kinase forms a complex with SHC, a protein that couples receptor tyrosine kinases to p21ras...
  21. Pajtler K, Rebmann V, Lindemann M, Schulte J, Schulte S, Stauder M, et al. Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cells. Int J Cancer. 2013;133:908-19 pubmed publisher
    High levels of the NTRK1/TrkA receptor are expressed in low-stage neuroblastomas, which are characterized by a good patient prognosis and often undergo spontaneous regression...
  22. Verpoorten N, Claeys K, Deprez L, Jacobs A, Van Gerwen V, Lagae L, et al. Novel frameshift and splice site mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with hereditary sensory neuropathy type IV. Neuromuscul Disord. 2006;16:19-25 pubmed
    ..NTRK1 mutations are only rarely reported in the European population. This report extends the spectrum of NTRK1 mutations observed in patients diagnosed with HSAN IV...
  23. Tuysuz B, Bayrakli F, DiLuna M, Bilguvar K, Bayri Y, Yalcinkaya C, et al. Novel NTRK1 mutations cause hereditary sensory and autonomic neuropathy type IV: demonstration of a founder mutation in the Turkish population. Neurogenetics. 2008;9:119-25 pubmed publisher
    ..This report broadens the spectrum of mutations in NTRK1 that cause HSAN IV and demonstrates a founder mutation in the Turkish population...
  24. Festuccia C, Muzi P, Gravina G, Millimaggi D, Speca S, Dolo V, et al. Tyrosine kinase inhibitor CEP-701 blocks the NTRK1/NGF receptor and limits the invasive capability of prostate cancer cells in vitro. Int J Oncol. 2007;30:193-200 pubmed
    ..However, the role of NGF and its receptors including the high-affinity p-140 TrkA and the low-affinity p75 NTR receptors remains controversial...
  25. Farina A, Tacconelli A, Cappabianca L, Cea G, Chioda A, Romanelli A, et al. The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells. Oncogene. 2009;28:4075-94 pubmed publisher
    ..Alternative splicing of the neurotrophin receptor tyrosine kinase TrkA may have a pivotal function in regulating NB behaviour, with reports suggesting that tumour-suppressing signals ..
  26. Robinson K, Manto K, Buchsbaum R, MacDonald J, Meakin S. Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA. J Biol Chem. 2005;280:225-35 pubmed
    ..we demonstrated a novel interaction between the intracellular domain of the nerve growth factor-regulated TrkA receptor tyrosine kinase and an N-terminal fragment of RasGrf1...
  27. Mardy S, Miura Y, Endo F, Matsuda I, Indo Y. Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor. Hum Mol Genet. 2001;10:179-88 pubmed
    Human TRKA (NTRK1) encodes the receptor tyrosine kinases (RTKs) for nerve growth factor (NGF) and is the gene responsible for congenital insensitivity to pain with anhidrosis (CIPA), an autosomal recessive disorder characterized by a lack ..
  28. Shatzky S, Moses S, Levy J, Pinsk V, Hershkovitz E, Herzog L, et al. Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies. Am J Med Genet. 2000;92:353-60 pubmed
    ..the linkage analysis approach, we linked the disease in 9 of 10 unrelated Israeli-Bedouin families with CIPA to the TrkA gene, which encodes the receptor for nerve growth factor...
  29. Weier H, Rhein A, Shadravan F, Collins C, Polikoff D. Rapid physical mapping of the human trk protooncogene (NTRK1) to human chromosome 1q21-q22 by P1 clone selection, fluorescence in situ hybridization (FISH), and computer-assisted microscopy. Genomics. 1995;26:390-3 pubmed
    ..Here, we demonstrate the scheme by mapping the human protooncogene trk (NTRK1), a tyrosine kinase receptor type I gene that has earlier been assigned to two different cytogenetic loci...
  30. Meldolesi J. Neurotrophin Trk Receptors: New Targets for Cancer Therapy. Rev Physiol Biochem Pharmacol. 2018;174:67-79 pubmed publisher
    ..b>TrkA, TrkB, and TrkC, activated by distinct neurotrophins, are high affinity stimulatory receptors...
  31. Calvo L, Anta B, López Benito S, Martín Rodriguez C, Lee F, Pérez P, et al. Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription. J Neurosci. 2015;35:7190-202 pubmed publisher
    ..Here, we show that rat Bex3 protein specifically regulates TrkA expression by acting at the trkA gene promoter level...
  32. Kuhlee A, Raunser S, Ungermann C. Functional homologies in vesicle tethering. FEBS Lett. 2015;589:2487-97 pubmed publisher
    The HOPS multisubunit tethering factor (MTC) is a macromolecular protein complex composed of six different subunits. It is one of the key components in the perception and subsequent fusion of multivesicular bodies and vacuoles...
  33. Abe Y, Tsukano S. Detection of early stage medullary thyroid carcinoma by measuring serum calcitonin using an electro chemiluminescence immuno-assay: A case report of a young Japanese woman with a high-risk RET mutation. Clin Pediatr Endocrinol. 2017;26:243-249 pubmed publisher
    Medullary thyroid carcinoma (MTC) in multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant disorder caused by the mutation of the RET proto-oncogene, that shows nearly complete penetration...
  34. Cohen M, Johnson W, Pilat J, Kiselar J, DeFrancesco Lisowitz A, Zigmond R, et al. Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons. Mol Cell Biol. 2015;35:4238-52 pubmed publisher
    ..TRPV2 colocalized with Rab7, a late endosome protein, in addition to TrkA and activated extracellular signal-regulated kinase (ERK) in neurites, indicating that the channel is closely ..
  35. Rajabi S, Hedayati M. Medullary Thyroid Cancer: Clinical Characteristics and New Insights into Therapeutic Strategies Targeting Tyrosine Kinases. Mol Diagn Ther. 2017;21:607-620 pubmed publisher
    Medullary thyroid carcinoma (MTC) is a hyperplasia of thyroid C-cells, accounting for 5-10% of all thyroid cancers...
  36. Rao R, Nalluri S, Fiskus W, Balusu R, Joshi A, Mudunuru U, et al. Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells. Mol Cancer Ther. 2010;9:2232-42 pubmed publisher
    ..induces autophosphorylation and downstream progrowth and prosurvival signaling from the receptor tyrosine kinase TrkA. Overexpression or activating mutation of TrkA has been described in human acute myeloid leukemia cells...
  37. Priya S, Dravid C, Digumarti R, Dandekar M. Targeted Therapy for Medullary Thyroid Cancer: A Review. Front Oncol. 2017;7:238 pubmed publisher
    ..Two drugs-vandetanib and cabozantinib-have been approved for use in progressive or metastatic MTC. In addition, several drugs acting on other steps of the molecular pathway are being investigated with promising ..
  38. Bano G, Hodgson S. Diagnosis and Management of Hereditary Thyroid Cancer. Recent Results Cancer Res. 2016;205:29-44 pubmed publisher
    Thyroid cancers are largely divided into medullary (MTC) and non-medullary (NMTC) cancers , depending on the cell type of origin...
  39. Restivo G, Diener J, Cheng P, Kiowski G, Bonalli M, Biedermann T, et al. low neurotrophin receptor CD271 regulates phenotype switching in melanoma. Nat Commun. 2017;8:1988 pubmed publisher
    ..intracellular domain of CD271 controls proliferation, while the interaction of CD271 with the neurotrophin receptor Trk-A modulates cell adhesiveness through dynamic regulation of a set of cholesterol synthesis genes relevant for ..
  40. Li M, Liang J, Sun Z, Zhang H, Yao Z. Novel nonsense and frameshift NTRK1 gene mutations in Chinese patients with congenital insensitivity to pain with anhidrosis. Genet Mol Res. 2012;11:2156-62 pubmed publisher
    ..Thirty-four among the 62 mutations (55%) are located within the tyrosine kinase domain of the NTRK1 protein. We concluded that the tyrosine kinase domain is a hot spot for mutations...
  41. Fang Z, Han B, Jung K, Lee J, El Damasy A, Gadhe C, et al. A novel tropomyosin-related kinase A inhibitor, KK5101 to treat pancreatic cancer. Cancer Lett. 2018;426:25-36 pubmed publisher
    Tropomyosin-related kinase A (TrkA) plays important roles in tumor cell growth and survival signaling and contributes to chemo-resistance in pancreatic cancer...
  42. Marler K, Becker Barroso E, MARTINEZ A, Llovera M, Wentzel C, Poopalasundaram S, et al. A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis. J Neurosci. 2008;28:12700-12 pubmed publisher
    ..The ephrinA/Trk interaction is neurotrophin induced and specifically augments the PI-3 kinase/Akt pathway generally known to be ..
  43. Hansen K, Wagner B, Hamel W, Schweizer M, Haag F, Westphal M, et al. Autophagic cell death induced by TrkA receptor activation in human glioblastoma cells. J Neurochem. 2007;103:259-75 pubmed
    The neurotrophin receptor tropomyosin-related kinase A (TrkA) and its ligand nerve growth factor (NGF) are expressed in astrocytomas, and an inverse association of TrkA expression with malignancy grade was described...
  44. Kuo E, Sho S, Li N, Zanocco K, Yeh M, Livhits M. Risk Factors Associated With Reoperation and Disease-Specific Mortality in Patients With Medullary Thyroid Carcinoma. JAMA Surg. 2017;: pubmed publisher
    The association of initial neck dissection with recurrence in medullary thyroid carcinoma (MTC) has not been evaluated on a population level to date.
  45. Fai P, Mbida M, Demefack J, Yamssi C. Potential of the microbial assay for risk assessment (MARA) for assessing ecotoxicological effects of herbicides to non-target organisms. Ecotoxicology. 2015;24:1915-22 pubmed publisher
    ..85 to 468 mg/l with an overall mean MTC of 101.82 mg/l for glyphosate and from 74.67 to 13,333 mg/l for 2,4-D giving an overall mean MTC of 2855.88 mg/l...
  46. Fujimoto M, Kitazawa R, Maeda S, Kitazawa S. Methylation adjacent to negatively regulating AP-1 site reactivates TrkA gene expression during cancer progression. Oncogene. 2005;24:5108-18 pubmed
    Nerve growth factor and its high-affinity receptor TrkA are thought to be involved in the progression of various cancers...
  47. Bae Y, Schaab M, Kratzsch J. Calcitonin as Biomarker for the Medullary Thyroid Carcinoma. Recent Results Cancer Res. 2015;204:117-37 pubmed publisher
    ..the influence of these factors, there is a high variability in assay-dependent cutoffs used to discriminate between MTC, C-cell hyperplasia (CCH), and the absence of the pathological impairment of C-cells...
  48. Ernani V, Kumar M, Chen A, Owonikoko T. Systemic treatment and management approaches for medullary thyroid cancer. Cancer Treat Rev. 2016;50:89-98 pubmed publisher
    Although rare, medullary thyroid cancer (MTC) exemplifies the value that ever-expanding knowledge of molecular pathways and mechanisms brings to managing challenging cancers...
  49. Yu L, Jiang Y, Tang B. Lin28a functionally modulates bupivacaine-induced dorsal root ganglion neuron apoptosis through TrkA activation. Biomed Pharmacother. 2018;98:63-68 pubmed publisher
    ..1?mM)-induced DRGN apoptosis was also measured. Finally, WB was used to examine Caspase-3/9 and TrkA protein expressions in Lin28a-downregualted and BUP-injured DRGN to explore Lin28a-associated signaling pathways...
  50. Liu Q, Tong D, Yuan W, Liu G, Yuan G, Lan W, et al. Different RET gene mutation-induced multiple endocrine neoplasia type 2A in 3 Chinese families. Medicine (Baltimore). 2017;96:e5967 pubmed publisher
    ..during transfection) gene that predisposes the carrier to extremely high risk of medullary thyroid cancer (MTC) and other MEN2A-associated tumors such as parathyroid cancer and/or pheochromocytoma...
  51. Davidson B, Lazarovici P, Ezersky A, Nesland J, Berner A, Risberg B, et al. Expression levels of the nerve growth factor receptors TrkA and p75 in effusions and solid tumors of serous ovarian carcinoma patients. Clin Cancer Res. 2001;7:3457-64 pubmed
    ..of this study was to analyze the expression of the high- and low-affinity nerve growth factor (NGF) receptors TrkA and p75 in effusions and in primary and metastatic tumors of serous ovarian carcinoma patients, as well as to ..
  52. Cheng Y, Loh Y, Birch N. Neuroserpin Attenuates H2O2-Induced Oxidative Stress in Hippocampal Neurons via AKT and BCL-2 Signaling Pathways. J Mol Neurosci. 2017;61:123-131 pubmed publisher
    ..level of neuroprotection over levels seen in neurons transduced with a BCL-2 expression vector, and an inhibitor of Trk receptors, K252a, did not block neuroserpin's effect...
  53. Spitschak A, Meier C, Kowtharapu B, Engelmann D, Pützer B. MiR-182 promotes cancer invasion by linking RET oncogene activated NF-?B to loss of the HES1/Notch1 regulatory circuit. Mol Cancer. 2017;16:24 pubmed publisher
    ..RET proto-oncogene, a receptor tyrosine kinase, are responsible for the development of medullary thyroid carcinoma (MTC) and causative for multiple endocrine neoplasia (MEN) type 2A and 2B...
  54. Joe R, Flores A, Doche M, Cline J, Clutter E, Vander P, et al. Phosphorylation of the Unique C-Terminal Tail of the Alpha Isoform of the Scaffold Protein SH2B1 Controls the Ability of SH2B1α To Enhance Nerve Growth Factor Function. Mol Cell Biol. 2018;38: pubmed publisher
    ..expression, phosphorylation of Akt and phospholipase C-gamma (PLC-γ), and autophosphorylation of the NGF receptor TrkA. These functions were restored when Tyr753 in the α tail was mutated to phenylalanine...
  55. Hayashi K, Storesund T, Schreurs O, Khuu C, Husvik C, Karatsaidis A, et al. Nerve growth factor beta/pro-nerve growth factor and their receptors in normal human oral mucosa. Eur J Oral Sci. 2007;115:344-54 pubmed
    ..Cultured normal human oral mucosal keratinocytes expressed mRNA for NGF-beta/proNGF and for their receptors TrkA and p75(NTR)...
  56. Kohsaka S, Saito T, Akaike K, Suehara Y, Hayashi T, Takagi T, et al. Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion. Hum Pathol. 2018;72:167-173 pubmed publisher
    ..RNA sequencing and subsequent reverse-transcription polymerase chain reaction revealed alternative splicing forms of LMNA-NTRK1 fusion (Ex2-Ex10 and Ex2-Ex15). ..
  57. Woo C, Lucarelli E, Thiele C. NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number. Oncogene. 2004;23:1522-30 pubmed
    In neuroblastoma (NB), expression of the TrkA receptor is correlated with good prognosis while N-myc amplification is correlated with poor prognosis...
  58. Emami A, Nazem M, SHEKARRIZ R, Hedayati M. Micronutrient status (calcium, zinc, vitamins D and E) in patients with medullary thyroid carcinoma: A cross-sectional study. Nutrition. 2017;41:86-89 pubmed publisher
    The aim of this study was to evaluate the micronutrient status of Iranian patients with medullary thyroid carcinoma (MTC) and to analyze potential relationships with respect to MTC risk...
  59. Chmelařová M, Dvorakova E, Spacek J, Laco J, Mžik M, Palicka V. Promoter methylation of GATA4, WIF1, NTRK1 and other selected tumour suppressor genes in ovarian cancer. Folia Biol (Praha). 2013;59:87-92 pubmed
    ..These findings could potentially be used in screening of ovarian cancer, and may have implications for future chemotherapy based on epigenetic changes. ..
  60. Caobelli F, Chiaravalloti A, Evangelista L, Saladini G, Schillaci O, Vadrucci M, et al. Predictive and prognostic value of 18F-DOPA PET/CT in patients affected by recurrent medullary carcinoma of the thyroid. Ann Nucl Med. 2018;32:7-15 pubmed publisher
    Medullary thyroid carcinoma (MTC) is a malignancy accounting for about 5-8% of thyroid cancers. Serum calcitonin and carcinoembryonic antigen (CEA) levels are widely used to monitor disease progression...
  61. Valenciaga A, Grubbs E, Porter K, Wakely P, Williams M, Cote G, et al. REDUCED RETINOBLASTOMA PROTEIN EXPRESSION IS ASSOCIATED WITH DECREASED PATIENT SURVIVAL IN MEDULLARY THYROID CANCER. Thyroid. 2017;: pubmed publisher
    ..Murine models develop medullary thyroid carcinoma (MTC) after generalized loss of RB; however, RB expression in MTC has been evaluated only in a small number of tumors ..
  62. Mihara T, Ueda A, Hirayama M, Takeuchi T, Yoshida S, Naito K, et al. Detection of new anti-neutral glycosphingolipids antibodies and their effects on Trk neurotrophin receptors. FEBS Lett. 2006;580:4991-5 pubmed
    ..glycosphingolipids are resident in membrane lipid rafts where high affinity nerve growth factor (NGF) receptor, Trk is co-localized...
  63. Eliav U, Navon G. The role of magnetization transfer in the observed contrast in T1 weighted imaging under clinical setups. NMR Biomed. 2017;30: pubmed publisher
    ..implemented selective saturation recovery alone and together with the conventional magnetization transfer contrast (MTC) method...
  64. Shelton D, Sutherland J, Gripp J, Camerato T, Armanini M, Phillips H, et al. Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. J Neurosci. 1995;15:477-91 pubmed
    Using molecular cloning techniques, human homologs of the known members of the trk family of neurotrophin receptors have been cloned and sequenced...
  65. Assimakopoulou M, Zolota V, Chondrogianni C, Gatzounis G, Varakis J. p75 and TrkC neurotrophin receptors demonstrate a different immunoreactivity profile in comparison to TrkA and TrkB receptors in human normal pituitary gland and adenomas. Neuroendocrinology. 2008;88:127-34 pubmed publisher
    ..indicates that neurotrophins play a significant role in neuroendocrine systems through their specific receptors TrkA, TrkB, TrkC and low-affinity p75(NTR) receptor...
  66. Peng W, Maintz L, Allam J, Raap U, Gütgemann I, Kirfel J, et al. Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis. Blood. 2013;122:1779-88 pubmed publisher
    ..We could demonstrate expression of high-affinity NT receptors tropomyosin-related kinase A (TrkA) for nerve growth factor (NGF)-?, TrkB for brain-derived neurotrophic factor, and NT-4 and TrkC for NT-3 on skin ..
  67. Yamashita N, Joshi R, Zhang S, Zhang Z, Kuruvilla R. Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors. Dev Cell. 2017;42:626-639.e5 pubmed publisher
    ..that retrograde signaling by target-derived nerve growth factor (NGF) is necessary for soma-to-axon transcytosis of TrkA receptors in sympathetic neurons, and we define the molecular underpinnings of this positive feedback regulation ..
  68. Perini G, Della Bianca V, Politi V, Della Valle G, Dal Pra I, Rossi F, et al. Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines. J Exp Med. 2002;195:907-18 pubmed
    ..Together, our results indicate that neurons expressing p75(NTR), mostly if expressing also proinflammatory cytokine receptors, might be preferential targets of the cytotoxic action of Abeta in AD. ..
  69. Klein R, Jing S, Nanduri V, O ROURKE E, Barbacid M. The trk proto-oncogene encodes a receptor for nerve growth factor. Cell. 1991;65:189-97 pubmed
    ..In this study we show that the product of the human trk proto-oncogene (gp140trk) binds NGF with high affinity...
  70. Kaplan D, Miller F. Signal transduction by the neurotrophin receptors. Curr Opin Cell Biol. 1997;9:213-21 pubmed
    ..For example, TrkA activation induces cell death of neural tumor cells, and survival and differentiation of neurons...
  71. Greco A, Villa R, Pierotti M. Genomic organization of the human NTRK1 gene. Oncogene. 1996;13:2463-6 pubmed
    ..The sequence of the 5' flanking region indicates a high content in C/G, the absence of TATA box, the presence of several putative binding sites for Sp1, AP1, AP2, AP3, ATF and GCF transcription factors. ..
  72. Bernard Gauthier V, Mahringer A, Vesnaver M, Fricker G, Schirrmacher R. Design and synthesis of a fluorinated quinazoline-based type-II Trk inhibitor as a scaffold for PET radiotracer development. Bioorg Med Chem Lett. 2017;27:2771-2775 pubmed publisher
    ..Tyrosine kinase inhibitors (TKIs) of the tropomyosin receptor kinase family TrkA/B/C (encoded by NTRK1/2/3) are showing promises in the clinic for the treatment of cancer patients whose diseases ..
  73. Ho R, Minturn J, Simpson A, Iyer R, Light J, Evans A, et al. The effect of P75 on Trk receptors in neuroblastomas. Cancer Lett. 2011;305:76-85 pubmed publisher
    Neuroblastomas (NBs) with favorable outcome usually express TrkA, whereas unfavorable NBs frequently express TrkB and its cognate ligand BDNF...
  74. Ojiaku C, Cao G, Zhu W, Yoo E, Shumyatcher M, Himes B, et al. TGF-β1 Evokes Human Airway Smooth Muscle Cell Shortening and Hyperresponsiveness via Smad3. Am J Respir Cell Mol Biol. 2017;: pubmed publisher
    ..lung slices (hPCLS) and in isolated HASM cells using supravital microscopy and magnetic twisting cytometry (MTC), respectively...
  75. Schlosser A, Hamann A, Bossemeyer D, Schneider E, Bakker E. NAD+ binding to the Escherichia coli K(+)-uptake protein TrkA and sequence similarity between TrkA and domains of a family of dehydrogenases suggest a role for NAD+ in bacterial transport. Mol Microbiol. 1993;9:533-43 pubmed
    The nucleotide sequence of trkA, a gene encoding a surface component of the constitutive K(+)-uptake systems TrkG and TrkH from Escherichia coli, was determined...
  76. Guo Y, Liao K, Soong B, Tsai C, Niu D, Lee H, et al. Congenital insensitivity to pain with anhidrosis in Taiwan: a morphometric and genetic study. Eur Neurol. 2004;51:206-14 pubmed
    ..In conclusion, the neuropathy of our CIPA patients included a marked reduction of small myelinated and unmyelinated fibers and a relatively increased axon size. This is the first CIPA family encountered in Taiwan. ..