Gene Symbol: TRIO
Description: trio Rho guanine nucleotide exchange factor
Alias: ARHGEF23, MEBAS, MRD44, tgat, triple functional domain protein, PTPRF-interacting protein, triple functional domain (PTPRF interacting)
Species: human
Products:     TRIO

Top Publications

  1. Seipel K, Medley Q, Kedersha N, Zhang X, O Brien S, Serra Pages C, et al. Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth. J Cell Sci. 1999;112 ( Pt 12):1825-34 pubmed
    ..b>Trio is a complex protein possessing two guanine nucleotide exchange factor domains, each with adjacent pleckstrin ..
  2. Medley Q, Serra Pages C, Iannotti E, Seipel K, Tang M, O Brien S, et al. The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain. J Biol Chem. 2000;275:36116-23 pubmed
    b>Trio is a complex protein containing two guanine nucleotide exchange factor domains each with associated pleckstrin homology domains, a serine/threonine kinase domain, two SH3 domains, an immunoglobulin-like domain, and spectrin-like ..
  3. Skowronek K, Guo F, Zheng Y, Nassar N. The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids. J Biol Chem. 2004;279:37895-907 pubmed
    The multidomain protein Trio regulates among others neuronal outgrowth and axonal guidance in vertebrates and invertebrates. Trio contains two Dbl-homology/pleckstrin homology (DH/PH) tandem domains that activate several RhoGTPases...
  4. Bellanger J, Astier C, Sardet C, Ohta Y, Stossel T, Debant A. The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin. Nat Cell Biol. 2000;2:888-92 pubmed
    ..Guanine nucleotide-exchange factors (GEFs) activate Rho GTPases by promoting their exchange of GDP for GTP. Trio is a unique Rho GEF, because it has separate GEF domains, GEFD1 and GEFD2, that control the GTPases RhoG/Rac1 and ..
  5. Ferraro F, Ma X, Sobota J, Eipper B, Mains R. Kalirin/Trio Rho guanine nucleotide exchange factors regulate a novel step in secretory granule maturation. Mol Biol Cell. 2007;18:4813-25 pubmed
    ..We show that Kalirin and Trio, homologous Rho guanine nucleotide exchange factors (GEFs), which interact with a secretory granule resident ..
  6. Moshfegh Y, Bravo Cordero J, Miskolci V, Condeelis J, Hodgson L. A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly. Nat Cell Biol. 2014;16:574-86 pubmed publisher
  7. Debant A, Serra Pages C, Seipel K, O BRIEN S, Tang M, Park S, et al. The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc Natl Acad Sci U S A. 1996;93:5466-71 pubmed
    ..transmembrane protein tyrosine phosphatase (PT-Pase), we isolated a cDNA encoding a 2861-amino acid protein termed Trio that contains three enzyme domains: two functional GEF domains and a protein serine/threonine kinase (PSK) domain...
  8. Medley Q, Buchbinder E, Tachibana K, Ngo H, Serra Pagès C, Streuli M. Signaling between focal adhesion kinase and trio. J Biol Chem. 2003;278:13265-70 pubmed
    The Trio guanine nucleotide exchange factor functions in neural development in Caenorhabditis elegans and Drosophila and in the development of neural tissues and skeletal muscle in mouse...
  9. Salhia B, Tran N, Chan A, Wolf A, Nakada M, Rutka F, et al. The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. Am J Pathol. 2008;173:1828-38 pubmed publisher
    ..Using a brain tumor expression database, we identified three GEFs, Trio, Ect2, and Vav3, that are expressed at higher levels in glioblastoma versus low-grade glioma...

More Information

Publications123 found, 100 shown here

  1. van Rijssel J, Hoogenboezem M, Wester L, Hordijk P, van Buul J. The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion. PLoS ONE. 2012;7:e29912 pubmed publisher
    The guanine-nucleotide exchange factor Trio encodes two DH-PH domains that catalyze nucleotide exchange on Rac1, RhoG and RhoA...
  2. Yi S, Kim H, Oh H, Shin H, Lee J, Park J, et al. Gene expression profiling of chondrogenic differentiation by dexamethasone-conjugated polyethyleneimine with SOX trio genes in stem cells. Stem Cell Res Ther. 2018;9:341 pubmed publisher
    ..Additionally, comprehensive examination of the gene expression was attempted to identify specific genes related to differentiation by microarray analysis. ..
  3. Agerholm J, McEvoy F, Heegaard S, Charlier C, Jagannathan V, Drogemuller C. A de novo missense mutation of FGFR2 causes facial dysplasia syndrome in Holstein cattle. BMC Genet. 2017;18:74 pubmed publisher
    ..linkage was obtained for three regions, including chromosome 26 where whole genome sequencing of a case-parent trio revealed two de novo variants perfectly associated with the disease: an intronic SNP in the DMBT1 gene and a single ..
  4. Jacobs F. [Lower respiratory tract infections in immunocompetent adult]. Rev Med Brux. 2017;38:313-319 pubmed
    ..If acute bronchitis is mainly of viral origin, acute exacerbations of COPD and pneumonia are mainly due to a trio of bacteria (Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis)...
  5. Balaram P, Hackett T, Polley D. Synergistic Transcriptional Changes in AMPA and GABAA Receptor Genes Support Compensatory Plasticity Following Unilateral Hearing Loss. Neuroscience. 2018;: pubmed publisher the system toward perceptual hypersensitivity, degraded temporal processing and the irrepressible perception of non-existent environmental stimuli, a trio of perceptual impairments that often accompany chronic sensory deprivation.
  6. Kuroda Y, Yuki T, Takahashi Y, Sakaguchi H, Matsunaga K, Itagaki H. Long form of thymic stromal lymphopoietin of keratinocytes is induced by protein allergens. J Immunotoxicol. 2017;14:178-187 pubmed publisher
    ..Additionally, TSLP production was induced by exposure to ovalbumin, WG, and acid-HWG in combination with a trio of cytokines, i.e. interleukin (IL)-4, IL-13, and tumor necrosis factor (TNF)-?...
  7. García de la serrana D, Devlin R, Johnston I. RNAseq analysis of fast skeletal muscle in restriction-fed transgenic coho salmon (Oncorhynchus kisutch): an experimental model uncoupling the growth hormone and nutritional signals regulating growth. BMC Genomics. 2015;16:564 pubmed publisher
    ..with 22 significantly downregulated in TR relative to WT fish, including 10 (vaspa, cdh15, graf1, crk, crkl, dock1, trio, plekho1a, cdc42a and dock5) associated with signaling through the cell surface protein cadherin...
  8. Wu D, Zhu X, Jimenez Cowell K, Mold A, Sollecito C, Lombana N, et al. Identification of the GTPase-activating protein DEP domain containing 1B (DEPDC1B) as a transcriptional target of Pitx2. Exp Cell Res. 2015;333:80-92 pubmed publisher
    ..RAC1 activation and interfered with actin polymerization induced by the guanine nucleotide exchange factor TRIO. Moreover, DEPDC1B interacted with various signaling molecules such as U2af2, Erh, and Salm...
  9. Kong Y, Xu K, Yuan K, Zhu J, Gu W, Liang L, et al. Digenetic inheritance of SLC12A3 and CLCNKB genes in a Chinese girl with Gitelman syndrome. BMC Pediatr. 2019;19:114 pubmed publisher
    ..patient, younger brother, parents, and grandparents were screened for gene variations and pedigree analysis using trio whole exome sequencing (WES). The candidate variants were validated by Sanger sequencing...
  10. Wheeler A, Czado N, Gangitano D, Turnbough M, Hughes Stamm S. Comparison of DNA yield and STR success rates from different tissues in embalmed bodies. Int J Legal Med. 2017;131:61-66 pubmed publisher
    ..DNA was purified from all samples using the QIAamp® FFPE Tissue Kit (Qiagen), quantified using the QuantiFiler® Trio DNA Quantification kit (Life Technologies), and genotyped using the GlobalFiler® PCR Amplification Kit (Life ..
  11. Kosfeld A, Brand F, Weiss A, Kreuzer M, Goerk M, Martens H, et al. Mutations in the leukemia inhibitory factor receptor (LIFR) gene and Lifr deficiency cause urinary tract malformations. Hum Mol Genet. 2017;26:1716-1731 pubmed publisher
    ..Using whole-exome sequencing and trio-based de novo analysis, we identified a novel heterozygous de novo frameshift variant in the leukemia inhibitory ..
  12. Mroske C, Rasmussen K, Shinde D, Huether R, Powis Z, Lu H, et al. Germline activating MTOR mutation arising through gonadal mosaicism in two brothers with megalencephaly and neurodevelopmental abnormalities. BMC Med Genet. 2015;16:102 pubmed publisher
    ..We report the successful application of family-trio Diagnostic Exome Sequencing (DES) to identify the underlying molecular etiology in two brothers with multiple ..
  13. Wise N, Frangos E, Komisaruk B. Brain Activity Unique to Orgasm in Women: An fMRI Analysis. J Sex Med. 2017;14:1380-1391 pubmed publisher
    ..Ten women experienced orgasm elicited by self- and partner-induced genital stimulation in a Siemens 3-T Trio fMRI scanner. Brain activity gradually increased leading up to orgasm, peaked at orgasm, and then decreased...
  14. Bramble M, Goldstein E, Lipson A, Ngun T, Eskin A, Gosschalk J, et al. A novel follicle-stimulating hormone receptor mutation causing primary ovarian failure: a fertility application of whole exome sequencing. Hum Reprod. 2016;31:905-14 pubmed publisher
    ..The affected siblings and both parents were sequenced (trio-WES)...
  15. Kurata K, Hosono K, Hikoya A, Kato A, Saitsu H, Minoshima S, et al. Clinical characteristics of a Japanese patient with Bardet-Biedl syndrome caused by BBS10 mutations. Jpn J Ophthalmol. 2018;62:458-466 pubmed publisher
    ..b>Trio-based whole-exome sequencing was performed to identify potential pathogenic mutations, confirmed by Sanger ..
  16. Kunz D, Oliveira G, Uchoa A, Samuels R, Macedo M, Silva C. Receptor mediated endocytosis of vicilin in Callosobruchus maculatus (Coleoptera: Chrysomelidae) larval midgut epithelial cells. Comp Biochem Physiol B Biochem Mol Biol. 2017;210:39-47 pubmed publisher
    ..The putative vicilin receptor showed high homology to proteins with the CRAL-TRIO domain, specifically the Sec14 superfamily member ?-tocopherol transfer protein...
  17. Auburn S, Fry A, Clark T, Campino S, Diakite M, Green A, et al. Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis. PLoS ONE. 2010;5:e10017 pubmed publisher
    ..Using meta-analysis across case-control and family trio (affected child and parental controls) studies of severe malaria from The Gambia and Malawi, we sought evidence of ..
  18. Lan X, Gao H, Wang F, Feng J, Bai J, Zhao P, et al. Whole-exome sequencing identifies variants in invasive pituitary adenomas. Oncol Lett. 2016;12:2319-2328 pubmed
    ..containing 2, with ZNF domain, RIZ1 (PRDM2), PR domain containing 8 (PRDM8), SPANX family member N2 (SPANXN2), TRIO and F-actin binding protein and zinc finger protein 717 in IPA specimens were 50% decreased compared with nIPA ..
  19. Shen Q, Eun J, Lee K, Kim H, Yang H, Kim S, et al. BANF1, PLOD3, SF3B4 as Early-stage Cancer Decision Markers and Drivers of Hepatocellular Carcinoma. Hepatology. 2017;: pubmed publisher
    ..capability to diagnose early-stage HCC in a large cohort of HCC patients, as compared to the currently popular trio of HCC diagnostic markers: glypican 3, glutamine synthetase, and heat-shock protein 70...
  20. Gerald B, Ramsey K, Belnap N, Szelinger S, Siniard A, Balak C, et al. Neonatal epileptic encephalopathy caused by de novo GNAO1 mutation misdiagnosed as atypical Rett syndrome: Cautions in interpretation of genomic test results. Semin Pediatr Neurol. 2018;26:28-32 pubmed publisher
    ..Whole exome sequencing was performed in this family trio, leading to the discovery of a rare, de novo, missense mutation in GNAO1 (p. Leu284Ser)...
  21. Altmann H, Tester D, Will M, Middha S, Evans J, Eckloff B, et al. Homozygous/Compound Heterozygous Triadin Mutations Associated With Autosomal-Recessive Long-QT Syndrome and Pediatric Sudden Cardiac Arrest: Elucidation of the Triadin Knockout Syndrome. Circulation. 2015;131:2051-60 pubmed publisher
    ..We performed whole-exome sequencing child-parent trio analysis followed by recessive and sporadic inheritance modeling and disease-network candidate analysis gene ..
  22. Li Y, Zhai Y, Song Q, Zhang H, Cao P, Ping J, et al. Genome-Wide Association Study Identifies a New Locus at 7q21.13 Associated with Hepatitis B Virus-Related Hepatocellular Carcinoma. Clin Cancer Res. 2018;24:906-915 pubmed publisher
    ..b>Experimental Design: GWAS scan is performed in a collection of 205 HBV-related HCC trios (each trio includes an affected proband and his/her both parents), and 355 chronic HBV carriers with HCC (cases) and 360 ..
  23. Zech M, Lam D, Weber S, Berutti R, Poláková K, Havrankova P, et al. A unique de novo gain-of-function variant in CAMK4 associated with intellectual disability and hyperkinetic movement disorder. Cold Spring Harb Mol Case Stud. 2018;: pubmed publisher
    ..We performed trio-whole-exome sequencing to identify a de novo essential splice-site variant (c...
  24. Seki Y, Miyasaka Y, Suzuki S, Wada K, Yasuda S, Matsuoka K, et al. A novel splice site mutation of myosin VI in mice leads to stereociliary fusion caused by disruption of actin networks in the apical region of inner ear hair cells. PLoS ONE. 2017;12:e0183477 pubmed publisher
    ..Interestingly, the expression of the stereociliary rootlet-specific TRIO and F-actin binding protein (TRIOBP) was altered in ksv/ksv mice...
  25. Baarda B, Emerson S, Proteau P, Sikora A. Deciphering the Function of New Gonococcal Vaccine Antigens Using Phenotypic Microarrays. J Bacteriol. 2017;199: pubmed publisher
    ..compounds, respectively, revealed three separate phenotype groups: NGO2121 and NGO1985; NGO1344 and BamE; and the trio of NGO1205, NGO2111, and NGO2054, with the last protein forming an independent branch of this cluster...
  26. Theis J, Hrstka S, Evans J, O Byrne M, de Andrade M, O Leary P, et al. Compound heterozygous NOTCH1 mutations underlie impaired cardiogenesis in a patient with hypoplastic left heart syndrome. Hum Genet. 2015;134:1003-11 pubmed publisher
    ..Dermal fibroblast-derived induced pluripotent stem cells (iPSC) were procured from the proband-parent trio and bioengineered into cardiomyocytes...
  27. Garg M, Nagata Y, Kanojia D, Mayakonda A, Yoshida K, Haridas Keloth S, et al. Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse. Blood. 2015;126:2491-501 pubmed publisher
    ..Of note, all AML matched trio samples shared at least 1 genomic alteration at diagnosis and relapse, suggesting common ancestral clones...
  28. Cook I, Wang T, Girvin M, Leyh T. The structure of the catechin-binding site of human sulfotransferase 1A1. Proc Natl Acad Sci U S A. 2016;113:14312-14317 pubmed
    ..mapped to the protein surface by triangulation using the T2 values to calculate their distances to a trio of spin-labeled Cys mutants. The final structure was obtained using distance-constrained molecular dynamics docking...
  29. Morales E, Vilahur N, Salas L, Motta V, Fernandez M, Murcia M, et al. Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy. Int J Epidemiol. 2016;45:1644-1655 pubmed
    ..related to birthweight in genome-wide association studies; cg20340720 (WBP1L); and cg25585967 and cg12294026 (TRIO). Dose-response relationships with maternal urine cotinine concentration during pregnancy were confirmed...
  30. Ji J, Quindipan C, Parham D, Shen L, Ruble D, Bootwalla M, et al. Inherited germline ATRX mutation in two brothers with ATR-X syndrome and osteosarcoma. Am J Med Genet A. 2017;173:1390-1395 pubmed publisher
    ..Both developed osteosarcoma. Trio exome sequencing (using blood samples from the younger brother and both parents) was performed and a nonsense ..
  31. Fischman R, Ruhl J. Judging adaptive management practices of U.S. agencies. Conserv Biol. 2016;30:268-75 pubmed publisher
    ..This trio of agency shortcuts around critical, iterative steps characterizes what we call AM-lite...
  32. Stevens S, van Essen A, van Ravenswaaij C, Elias A, Haven J, Lelieveld S, et al. Truncating de novo mutations in the Krüppel-type zinc-finger gene ZNF148 in patients with corpus callosum defects, developmental delay, short stature, and dysmorphisms. Genome Med. 2016;8:131 pubmed
    ..Our study illustrates the advantage of whole exome sequencing in a large cohort using a parent-offspring trio approach for identifying novel genes involved in rare human diseases.
  33. Li B, Ababon M, MATTESON P, Lin Y, Nanda V, Millonig J. Congenital Cataract in Gpr161vl/vl Mice Is Modified by Proximal Chromosome 15. PLoS ONE. 2017;12:e0170724 pubmed publisher
    ..polymorphisms, and the biological relevancy of the genes in the interval identified three genes (Cdh6, Ank and Trio) that likely contribute to the rescue of the lens phenotype...
  34. Shao L, Lu B, Wen Z, Teng S, Wang L, Zhao Y, et al. Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways. Hum Mol Genet. 2017;26:2634-2648 pubmed publisher
    ..We found that three pathways that include the homologs of Drosophila Dys, Trio, and Shot were downregulated by introducing a C-terminal truncated mutant DISC1...
  35. Campabadal A, Uribe C, Segura B, Baggio H, Abos A, Garcia Diaz A, et al. Brain correlates of progressive olfactory loss in Parkinson's disease. Parkinsonism Relat Disord. 2017;41:44-50 pubmed publisher
    ..Structural magnetic resonance imaging data, obtained with a 3-T Siemens Trio scanner, were analyzed using FreeSurfer software. Analysis of variance showed significant group (F = 53...
  36. Ramírez Chau C, Blanco R, Colombo A, Pardo R, Suazo J. MTHFR c.677C>T is a risk factor for non-syndromic cleft lip with or without cleft palate in Chile. Oral Dis. 2016;22:703-8 pubmed publisher
    ..We assessed this association in a Chilean population using a combined analysis of case-control and case-parent trio samples. Samples of 165 cases and 291 controls and 121 case-parent trios (sharing the cases) were genotyped...
  37. Braverman J, Hamilton M, Johnson B. Patterns of Substitution Rate Variation at Many Nuclear Loci in Two Species Trios in the Brassicaceae Partitioned with ANOVA. J Mol Evol. 2016;83:97-109 pubmed
    ..have faster rates of substitution on the branch leading to the annual than to the perennial for one three-species trio but not another...
  38. Wong J, Campbell D, Ngo N, Yeung F, Cheng G, Tang C, et al. Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes. BMC Med Genomics. 2016;9:75 pubmed
    ..To our knowledge, no genetic study has ever been conducted. We aim to identify genetic risk factors by a "trio-based" exome-sequencing approach, whereby 31 CDD probands and their unaffected parents were exome-sequenced...
  39. Lee H, Langham M, Rodriguez Soto A, Wehrli F. Multiplexed MRI methods for rapid estimation of global cerebral metabolic rate of oxygen consumption. Neuroimage. 2017;149:393-403 pubmed publisher
    ..The two sequences were implemented on 3T scanners (Siemens TIM Trio and Prisma) and their performance was evaluated in comparison to Conv-OxFlow in ten healthy subjects for baseline ..
  40. Lee W, Chatterjee S, Yap S, Lim S, Xing X, Kraus P, et al. An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos. Biomed Res Int. 2017;2017:8932583 pubmed publisher
    ..Some of the key transcription factors controlling specific cell types are the Sox trio, namely, Sox5, Sox6, and Sox9, which play crucial roles in organogenesis working in a ..
  41. Ferrandez Y, Zhang W, Peurois F, Akendengué L, Blangy A, Zeghouf M, et al. Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule. Sci Rep. 2017;7:14409 pubmed publisher
    ..In contrast, another Dock inhibitor, CPYPP, inhibits both DOCK5 and an unrelated GEF, Trio. To gain insight into structural features of the inhibitory mechanism of C21, we used SAXS analysis of DOCK5..
  42. Langlois S, Tarailo Graovac M, Sayson B, Drögemöller B, Swenerton A, Ross C, et al. De novo dominant variants affecting the motor domain of KIF1A are a cause of PEHO syndrome. Eur J Hum Genet. 2016;24:949-53 pubmed publisher
    ..followed by Sanger confirmation identified nine candidate genes harboring nonsynonymous rare variants identified by trio whole-exome sequencing. The de novo variant, a missense variant (c.296C>T, p...
  43. McEntagart M, Williamson K, Rainger J, Wheeler A, Seawright A, De Baere E, et al. A Restricted Repertoire of De Novo Mutations in ITPR1 Cause Gillespie Syndrome with Evidence for Dominant-Negative Effect. Am J Hum Genet. 2016;98:981-992 pubmed publisher
    ..b>Trio-based exome sequencing identified de novo mutations in ITPR1 in three unrelated individuals with GS recruited to ..
  44. Mukherji D, Marques C, Kremer K. Collapse in two good solvents, swelling in two poor solvents: defying the laws of polymer solubility?. J Phys Condens Matter. 2017;: pubmed publisher
    ..A broad range of polymers is therefore expected to exhibit these phenomena where specific chemical details play a lesser role than the appropriate combination of interactions between the trio of molecular components.
  45. Herring B, Nicoll R. Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP. Proc Natl Acad Sci U S A. 2016;113:2264-9 pubmed publisher
    ..of molecular, electrophysiological, and imaging techniques, we show that the RhoGEF Kalirin and its paralog Trio play critical and redundant roles in excitatory synapse structure and function...
  46. Petrescu Mag R, Petrescu D, Oroian I, Safirescu O, Bican Brișan N. Environmental Equity through Negotiation: A Case Study on Urban Landfills and the Roma Community. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..How can it be attained?", and "To what extent can it be brought to the targeted people?" It was shown how a trio of factors tailors the destiny of Roma inhabitants: being a minority, their ethnicity, and the fact they are living ..
  47. Reuter M, Riess A, Moog U, Briggs T, Chandler K, Rauch A, et al. FOXP2 variants in 14 individuals with developmental speech and language disorders broaden the mutational and clinical spectrum. J Med Genet. 2017;54:64-72 pubmed publisher
    ..Chromosomal microarray testing, trio exome sequencing, multigene panel sequencing and targeted sequencing of FOXP2 were performed in individuals with ..
  48. Macias Muñoz A, McCulloch K, Briscoe A. Copy number variation and expression analysis reveals a non-orthologous pinta gene family member involved in butterfly vision. Genome Biol Evol. 2017;: pubmed publisher
    Vertebrate (CRALBP) and Drosophila (PINTA) proteins with a CRAL-TRIO domain transport retinal-based chromophores that bind to opsin proteins and are necessary for phototransduction...
  49. O Brien N, Fiorentino A, Curtis D, Rayner C, Petrosellini C, Al Eissa M, et al. Rare variant analysis in multiply affected families, association studies and functional analysis suggest a role for the ITGΒ4 gene in schizophrenia and bipolar disorder. Schizophr Res. 2018;199:181-188 pubmed publisher
    ..A gene-wise weighted burden test was performed on a trio sample of schizophrenia cases and their parents. rs750367954 was seen in two Swedish cases and in no controls...
  50. Tang M, Liang Y, Chan J, Wong S, Chen E, Yao Y, et al. Promyelocytic leukemia (PML) protein plays important roles in regulating cell adhesion, morphology, proliferation and migration. PLoS ONE. 2013;8:e59477 pubmed publisher
    ..Nine proteins (PML, NDRG1, CACYBP, CFL1, RSU1, TRIO, CTRO, ANXA4 and UBE2M) were determined to be down-regulated in PML(-/-) MEFs...
  51. Guérin A, Bussières J, Boulkedid R, Bourdon O, Prot Labarthe S. Development of a consensus-base list of criteria for prescribing medication in a pediatric population. Int J Clin Pharm. 2015;37:883-94 pubmed publisher
    ..Multicenter with a trio of experts from eight university hospitals...
  52. Hamlet S, Haggerty C, Suever J, Wehner G, Grabau J, Andres K, et al. An interactive videogame designed to improve respiratory navigator efficiency in children undergoing cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2016;18:54 pubmed publisher
    ..Using a 3T Siemens Tim Trio, 50 children (Age: 14 ± 3 years, 48 % female) with no significant past medical history underwent a ..
  53. Gorman K, Aird J, Conroy J, Devaney D, Farrell M, King M. Symmetrical thalamic calcification: A trio whole exome sequencing negative series. Brain Dev. 2017;39:426-430 pubmed publisher
    ..We performed trio whole exome sequencing, the first in this cohort of patients, and did not identify a pathogenic variant...
  54. Reznik E, Wang Q, La K, Schultz N, Sander C. Mitochondrial respiratory gene expression is suppressed in many cancers. elife. 2017;6: pubmed publisher
    ..Several cancers exhibit a trio of mutually consistent evidence suggesting a drop in respiratory activity: depletion of mtDNA copy number, ..
  55. Scimone C, Donato L, Esposito T, Rinaldi C, D Angelo R, Sidoti A. A novel RLBP1 gene geographical area-related mutation present in a young patient with retinitis punctata albescens. Hum Genomics. 2017;11:18 pubmed publisher
    ..involves the exon 6 and leads to a premature stop codon, resulting in a truncated protein entirely missing of CRAL-TRIO lipid-binding domain...
  56. Yoo H, Thayer J, Greening S, Lee T, Ponzio A, Min J, et al. Brain structural concomitants of resting state heart rate variability in the young and old: evidence from two independent samples. Brain Struct Funct. 2018;223:727-737 pubmed publisher
    ..MRI scans were performed on a 3.0-T Siemens Magnetom Trio scanner...
  57. Portales Casamar E, Briançon Marjollet A, Fromont S, Triboulet R, Debant A. Identification of novel neuronal isoforms of the Rho-GEF Trio. Biol Cell. 2006;98:183-93 pubmed
    ..The multidomain protein Trio is the founding member of an intriguing subfamily of Rho-GEFs exhibiting two Rho-GEF and numerous additional ..
  58. Boraska V, Zeggini E, Groves C, Rayner N, Skrabić V, Diakite M, et al. Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia. Hum Immunol. 2009;70:195-9 pubmed publisher
    ..11 TNF/LTA tag polymorphisms, designed to capture the majority of common variation in the region, in 160 trio families from South Croatia...
  59. Barclay S, Rand C, Borch L, Nguyen L, Gray P, Gibson W, et al. Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD): exome sequencing of trios, monozygotic twins and tumours. Orphanet J Rare Dis. 2015;10:103 pubmed publisher
    ..The analysis of the trio-based exomes found 13 de novo variants...
  60. Xiong W, Wang D, Gao Y, Gao Y, Wang H, Guan J, et al. Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment. Sci China Life Sci. 2015;58:829-38 pubmed publisher
    ..At the 13th week of gestation, genomic DNA (gDNA) from the trio family and cell-free DNA (cfDNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy ..
  61. Balliu B, Zaitlen N. A Novel Test for Detecting SNP-SNP Interactions in Case-Only Trio Studies. Genetics. 2016;202:1289-97 pubmed publisher
    ..In this work we develop a new SNP-SNP interaction test for use in case-only trio studies called the trio correlation (TC) test...
  62. Lyons L, Creighton E, Alhaddad H, Beale H, Grahn R, Rah H, et al. Whole genome sequencing in cats, identifies new models for blindness in AIPL1 and somite segmentation in HES7. BMC Genomics. 2016;17:265 pubmed publisher
    ..The first WGS in cats was conducted on a trio segregating for LCA and the bobbed tail abnormality...
  63. Godel T, Pham M, Heiland S, Bendszus M, Bäumer P. Human dorsal-root-ganglion perfusion measured in-vivo by MRI. Neuroimage. 2016;141:81-87 pubmed publisher
    ..without known peripheral neuropathies or pain syndromes were examined by a 3Tesla MRI scanner (Magnetom VERIO or TRIO, Siemens AG, Erlangen, Germany) with a VIBE (Volume-Interpolated-Breathhold-Examination) dynamic-contrast-enhanced (..
  64. Liu N, Yang Y, Ge L, Liu M, Colecraft H, Liu X. Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca2+ channels. elife. 2017;6: pubmed publisher
    ..g., by constitutive fusion, facilitates the trio to form the complex, compete against calmodulin, and alter the gating...
  65. Archer N, Pérez Andreu V, Stoltze U, Scheurer M, Wilkinson A, Lin T, et al. Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility. PLoS ONE. 2017;12:e0180488 pubmed publisher
    ..We used a case-parent trio study design; unlike more commonly used case-control studies, this study design is ideal for avoiding issues with ..
  66. Nguyen H, Bryois J, Kim A, Dobbyn A, Huckins L, Muñoz Manchado A, et al. Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders. Genome Med. 2017;9:114 pubmed publisher
    Integrating rare variation from trio family and case-control studies has successfully implicated specific genes contributing to risk of neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASD), intellectual disability ..
  67. Braden G, Rasmussen S, Monette S, Tolwani R. Effects of Breeding Configuration on Maternal and Weanling Behavior in Laboratory Mice. J Am Assoc Lab Anim Sci. 2017;56:369-376 pubmed
    ..2 We sought to determine the effects of pair, trio, and harem breeding configurations on the maternal and weanling behavior of C57BL/6J (B6) and 129S6/SvEvTac (129) ..
  68. Xiao Y, Xiong J, Mao D, Liu L, Li J, Li X, et al. Early-onset epileptic encephalopathy with de novo SCN8A mutation. Epilepsy Res. 2018;139:9-13 pubmed publisher
    ..Epilepsy Gene Panel Testing (containing 511 epilepsy-related genes) was performed in a parent-offspring trio. In this family, the son had refractory seizures, intellectual disability, and motor abnormalities, and he was ..
  69. Adamowicz M, Radlwimmer B, Rieker R, Mertens D, Schwarzbach M, Schraml P, et al. Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas. Genes Chromosomes Cancer. 2006;45:829-38 pubmed
    ..From these regions, genes TERT, TRIO, SKP2, FBXO32, NKD2, SLC6A3, IRX2, POLS, FYB, PTGER4, and FGF10 were selected for detailed quantitative expression ..
  70. van Rijssel J, Kroon J, Hoogenboezem M, van Alphen F, de Jong R, Kostadinova E, et al. The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation. Mol Biol Cell. 2012;23:2831-44 pubmed publisher
    ..In this study, our data reveal that both full-length Trio and the first DH-PH (TrioD1) domain of Trio, which can activate Rac1 and RhoG, interact with ICAM-1 and are ..
  71. Wang B, Fang J, Qu L, Cao Z, Zhou J, Deng B. Upregulated TRIO expression correlates with a malignant phenotype in human hepatocellular carcinoma. Tumour Biol. 2015;36:6901-8 pubmed publisher
    b>Triple functional domain protein (TRIO) is an evolutionarily conserved Dbl family guanine nucleotide exchange factors (GEFs) involved in cell proliferation and progression of some types of cancer...
  72. Timmerman I, Heemskerk N, Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, et al. A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1. J Cell Sci. 2015;128:3041-54 pubmed publisher
    ..Here, we identify a crucial role for the Rho-GEF Trio in stabilizing junctions based around vascular endothelial (VE)-cadherin (also known as CDH5)...
  73. Ba W, Yan Y, Reijnders M, Schuurs Hoeijmakers J, Feenstra I, Bongers E, et al. TRIO loss of function is associated with mild intellectual disability and affects dendritic branching and synapse function. Hum Mol Genet. 2016;25:892-902 pubmed publisher
    Recently, we marked TRIO for the first time as a candidate gene for intellectual disability (ID). Across diverse vertebrate species, TRIO is a well-conserved Rho GTPase regulator that is highly expressed in the developing brain...
  74. Charpentier T, Waldo G, Lowery Gionta E, Krajewski K, Strahl B, Kash T, et al. Potent and Selective Peptide-based Inhibition of the G Protein G?q. J Biol Chem. 2016;291:25608-25616 pubmed
    ..of effectors, the phospholipase C (PLC)-? isozymes and Rho guanine nucleotide exchange factors (RhoGEFs) related to Trio, in a strikingly similar fashion: a continuous helix-turn-helix of the effectors engages G?q within its ..
  75. Kloth K, Denecke J, Hempel M, Johannsen J, Strom T, Kubisch C, et al. First de novo ANK3 nonsense mutation in a boy with intellectual disability, speech impairment and autistic features. Eur J Med Genet. 2017;60:494-498 pubmed publisher
    ..By trio-whole-exome sequencing, we identified the first de novo nonsense mutation affecting all ANK3 transcripts...
  76. Dove K, Kemp H, Di Bona K, Reiter K, Milburn L, Camacho D, et al. Two functionally distinct E2/E3 pairs coordinate sequential ubiquitination of a common substrate in Caenorhabditis elegans development. Proc Natl Acad Sci U S A. 2017;114:E6576-E6584 pubmed publisher
    ..the crucial posttranslational modification that regulates the eukaryotic proteome, is carried out by a trio of enzymes, known as E1 [ubiquitin (Ub)-activating enzyme], E2 (Ub-conjugating enzyme), and E3 (Ub ligase)...
  77. Cavallin M, Rujano M, Bednarek N, Medina Cano D, Bernabe Gelot A, Drunat S, et al. WDR81 mutations cause extreme microcephaly and impair mitotic progression in human fibroblasts and Drosophila neural stem cells. Brain. 2017;140:2597-2609 pubmed publisher
    ..We performed trio-based whole exome sequencing in seven subjects from five non-consanguineous families who presented with either ..
  78. Flaherty E, Deranieh R, Artimovich E, Lee I, Siegel A, Levy D, et al. Patient-derived hiPSC neurons with heterozygous CNTNAP2 deletions display altered neuronal gene expression and network activity. NPJ Schizophr. 2017;3:35 pubmed publisher
    ..We previously reprogrammed fibroblasts from a family trio consisting of two carriers of heterozygous intragenic CNTNAP2 deletions into human induced pluripotent stem cells (..
  79. Li R, Zhang C, Li H, Wu R, Li H, Tang Z, et al. SNP typing using the HID-Ion AmpliSeq™ Identity Panel in a southern Chinese population. Int J Legal Med. 2018;132:997-1006 pubmed publisher
    ..81 × 10-34 and the combined power of exclusion (CPE) was 0.99989 and 0.99999992 for duo and trio paternity testing, respectively...
  80. Oak P, Hilgendorff A. The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease. Mol Cell Pediatr. 2017;4:11 pubmed publisher
    ..We emphasize the shared and distinct role of these pathways as well as their interconnection in disease initiation and progression, generating important knowledge for the development of future treatment strategies. ..
  81. Milner J. Sunlight and Other Disinfectants: Disclosure Obligations under the Federal Securities and Drug Regulatory Regimes. Food Drug Law J. 2017;72:141-88 pubmed
    ..Moreover, a trio of federal statutes requires FDA to keep sensitive information submitted by drug companies confidential...
  82. Del Campo J, James E, Hirakawa Y, Fiorito R, Kolisko M, Irwin N, et al. Pseudotrichonympha leei, Pseudotrichonympha lifesoni, and Pseudotrichonympha pearti, new species of parabasalian flagellates and the description of a rotating subcellular structure. Sci Rep. 2017;7:16349 pubmed publisher
    ..hertwigi. Pseudotrichonympha pearti is the outlier of the trio, more distantly related to P. leei and P...
  83. Zheng M, Simon R, Mirlacher M, Maurer R, Gasser T, Forster T, et al. TRIO amplification and abundant mRNA expression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer. Am J Pathol. 2004;165:63-9 pubmed
    ..In this study seven genes (TAS2R, ADCY2, DNAH5, CTNND2, TRIO, ANKH, and MYO10) located to 5p15.31-5p15...
  84. Liu X, Bera T, Kahue C, Escobar T, Fei Z, Raciti G, et al. ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. PLoS ONE. 2012;7:e38130 pubmed publisher
    ..We identified by yeast two-hybrid and immunoprecipitation assays the triple functional domain protein (TRIO), the G protein pathway suppressor 2 (GPS2), the delta-interacting protein A (DIPA) and the ..
  85. Dove K, Klevit R. RING-Between-RING E3 Ligases: Emerging Themes amid the Variations. J Mol Biol. 2017;429:3363-3375 pubmed publisher
    ..The process is carried out by a trio of enzymes: a Ub-activating (E1) enzyme, a Ub-conjugating (E2) enzyme, and a Ub ligase (E3) enzyme...
  86. Katrancha S, Wu Y, Zhu M, Eipper B, Koleske A, Mains R. Neurodevelopmental disease-associated de novo mutations and rare sequence variants affect TRIO GDP/GTP exchange factor activity. Hum Mol Genet. 2017;26:4728-4740 pubmed publisher, we identified an enrichment of de novo mutations in the gene encoding the 330-kDa triple functional domain (TRIO) protein associated with neurodevelopmental disorders...
  87. Flaherty E, Deranieh R, Artimovich E, Lee I, Siegel A, Levy D, et al. Patient-derived hiPSC neurons with heterozygous CNTNAP2 deletions display altered neuronal gene expression and network activity. NPJ Schizophr. 2017;3:35 pubmed publisher
    ..We previously reprogrammed fibroblasts from a family trio consisting of two carriers of heterozygous intragenic CNTNAP2 deletions into human induced pluripotent stem ..
  88. Lin W, Chen W, Liu C, Hwu H, McCarroll S, Glatt S, et al. Adaptive combination of Bayes factors as a powerful method for the joint analysis of rare and common variants. Sci Rep. 2017;7:13858 pubmed publisher
    ..We also analyzed 1,109 case-parent trios from the Schizophrenia Trio Genomic Research in Taiwan. Three genes on chromosome 19p13...
  89. Zhang Y, Liu Y, Zarrei M, Tong W, Dong R, Wang Y, et al. Association of IMMP2L deletions with autism spectrum disorder: A trio family study and meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2017;: pubmed publisher
    ..Here we genotyped 100 trio families with an index proband with autism spectrum disorder in Han Chinese population and found three cases with ..
  90. Holmes A, Houston R, Elwick K, Gangitano D, Hughes Stamm S. Evaluation of four commercial quantitative real-time PCR kits with inhibited and degraded samples. Int J Legal Med. 2018;132:691-701 pubmed publisher
    ..compares the results from four commercial qPCR kits: (1) Investigator® Quantiplex® Pro Kit, (2) Quantifiler® Trio DNA Quantification Kit, (3) PowerQuant® System, and (4) InnoQuant® HY with high molecular weight DNA, low ..
  91. Hou C, Zhuang Z, Deng X, Xu Y, Zhang P, Zhu L. Knockdown of Trio by CRISPR/Cas9 suppresses migration and invasion of cervical cancer cells. Oncol Rep. 2017;: pubmed publisher
    b>Triple functional domain protein (Trio) is an evolutionarily conserved protein with guanine nucleotide exchange factors that regulate different physiological processes in some types of cancer...
  92. Gross A, Tonjes A, Scholz M. On the impact of relatedness on SNP association analysis. BMC Genet. 2017;18:104 pubmed publisher
    ..We apply the developed theory to the publicly available HapMap trio data (N=129), the Sorbs (a self-contained population with N=977 characterised by a cryptic relatedness structure) ..