TRIM63

Summary

Gene Symbol: TRIM63
Description: tripartite motif containing 63
Alias: IRF, MURF1, MURF2, RNF28, SMRZ, E3 ubiquitin-protein ligase TRIM63, RING-type E3 ubiquitin transferase TRIM63, iris ring finger protein, muscle specific ring finger protein 2, muscle-specific RING finger protein 1, ring finger protein 28, striated muscle RING zinc finger protein, tripartite motif containing 63, E3 ubiquitin protein ligase, tripartite motif-containing protein 63
Species: human
Products:     TRIM63

Top Publications

  1. Doucet M, Russell A, Leger B, Debigare R, Joanisse D, Caron M, et al. Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2007;176:261-9 pubmed
    ..The levels of atrogin-1 and MuRF1 mRNA, and of phosphorylated AKT and 4E-BP1 and FoxO-1 proteins, were increased in patients with COPD with muscle ..
  2. Lange S, Xiang F, Yakovenko A, Vihola A, Hackman P, Rostkova E, et al. The kinase domain of titin controls muscle gene expression and protein turnover. Science. 2005;308:1599-603 pubmed
    ..Nbr1 targets the ubiquitin-associated p62/SQSTM1 to sarcomeres, and p62 in turn interacts with MuRF2, a muscle-specific RING-B-box E3 ligase and ligand of the transactivation domain of the serum response ..
  3. Dai K, Liew C. A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain. J Biol Chem. 2001;276:23992-9 pubmed
    ..sequence tag data base for genes encoding the RING domain identified a novel cDNA, named striated muscle RING zinc finger protein (SMRZ). The SMRZ cDNA is 1...
  4. Eddins M, Marblestone J, Suresh Kumar K, Leach C, Sterner D, Mattern M, et al. Targeting the ubiquitin E3 ligase MuRF1 to inhibit muscle atrophy. Cell Biochem Biophys. 2011;60:113-8 pubmed publisher
    ..The ubiquitin E3 ligase Muscle-specific RING Finger E3 ligase (MuRF1) is upregulated and increases protein degradation and muscle wasting in numerous muscle atrophy models...
  5. Pizon V, Iakovenko A, van der Ven P, Kelly R, Fatu C, Furst D, et al. Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein. J Cell Sci. 2002;115:4469-82 pubmed
    ..We show here that the novel tubulin-associated RING/B-box protein MURF2 associates transiently with microtubules, myosin and titin during sarcomere assembly...
  6. Chen S, Czernuszewicz G, Tan Y, Lombardi R, Jin J, Willerson J, et al. Human molecular genetic and functional studies identify TRIM63, encoding Muscle RING Finger Protein 1, as a novel gene for human hypertrophic cardiomyopathy. Circ Res. 2012;111:907-19 pubmed publisher
    A delicate balance between protein synthesis and degradation maintains cardiac size and function. TRIM63 encoding Muscle RING Finger 1 (MuRF1) maintains muscle protein homeostasis by tagging the sarcomere proteins with ubiquitin for ..
  7. Franke B, Gasch A, Rodríguez D, Chami M, Khan M, Rudolf R, et al. Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1. Open Biol. 2014;4:130172 pubmed publisher
    b>MuRF1 is an E3 ubiquitin ligase central to muscle catabolism. It belongs to the TRIM protein family characterized by a tripartite fold of RING, B-box and coiled-coil (CC) motifs, followed by variable C-terminal domains...
  8. McElhinny A, Kakinuma K, Sorimachi H, Labeit S, Gregorio C. Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. J Cell Biol. 2002;157:125-36 pubmed
    ..The dual interactions of MURF-1 with titin and GMEB-1 may link myofibril signaling pathways (perhaps including titin's kinase domain) with muscle gene expression. ..
  9. Witt C, Witt S, Lerche S, Labeit D, Back W, Labeit S. Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2. EMBO J. 2008;27:350-60 pubmed
    The muscle-specific RING finger proteins MuRF1 and MuRF2 have been proposed to regulate protein degradation and gene expression in muscle tissues...

More Information

Publications125 found, 100 shown here

  1. Kedar V, McDonough H, Arya R, Li H, Rockman H, Patterson C. Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Proc Natl Acad Sci U S A. 2004;101:18135-40 pubmed
    Muscle-specific RING finger protein 1 (MuRF1) is a sarcomere-associated protein that is restricted to cardiac and skeletal muscle...
  2. Moriscot A, Baptista I, Bogomolovas J, Witt C, Hirner S, Granzier H, et al. MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance. J Struct Biol. 2010;170:344-53 pubmed publisher
    b>MuRF1 is a member of the RBCC (RING, B-box, coiled-coil) superfamily that has been proposed to act as an atrogin during muscle wasting. Here, we show that MuRF1 is preferentially induced in type-II muscle fibers after denervation...
  3. Mrosek M, Labeit D, Witt S, Heerklotz H, von Castelmur E, Labeit S, et al. Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin. FASEB J. 2007;21:1383-92 pubmed
  4. Centner T, Yano J, Kimura E, McElhinny A, Pelin K, Witt C, et al. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. J Mol Biol. 2001;306:717-26 pubmed
    ..kinase activity similar to other known kinase-associated proteins, whereas differential expression and heterodimerization of MURF1, 2 and 3 may link together titin kinase and microtubule-dependent signal pathways in striated muscles.
  5. de Boer M, Selby A, Atherton P, Smith K, Seynnes O, Maganaris C, et al. The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse. J Physiol. 2007;585:241-51 pubmed
  6. Bodine S, Latres E, Baumhueter S, Lai V, Nunez L, Clarke B, et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 2001;294:1704-8 pubmed
    ..Two of these genes encode ubiquitin ligases: Muscle RING Finger 1 (MuRF1), and a gene we designate Muscle Atrophy F-box (MAFbx), the latter being a member of the SCF family of E3 ..
  7. Sun Z, Wang B, Liu Y, Liu X, Mi Y, Gu M, et al. Genome organization and transcriptional regulation of Adenosine Deaminase Acting on RNA gene 1 (ADAR1) in grass carp (Ctenopharyngodon idella). Dev Comp Immunol. 2015;50:98-105 pubmed publisher
    ..two distinct regions, the proximal region containing three putative interferon regulatory factor binding elements (IRF-E) and the distal region containing only one IRF-E...
  8. Wang B, Liu Y, Sun Z, Liu X, Mi Y, Liu D, et al. A splicing isoform of Ctenopharyngodon idella ADAR1 (CiADAR1-like): Genome organization, tissue specific expression and transcriptional regulation. Fish Shellfish Immunol. 2015;47:535-44 pubmed publisher
    ..CiADAR1-like promoter is 1173 bp in length containing 3 ISRE and 8 IRF-E...
  9. Xie W, Lv A, Li R, Tang Z, Ma D, Huang X, et al. Agaricus blazei Murill Polysaccharides Protect Against Cadmium-Induced Oxidative Stress and Inflammatory Damage in Chicken Spleens. Biol Trace Elem Res. 2018;184:247-258 pubmed publisher
    ..ABP significantly reduced the accumulation of Cd in the chicken spleens and reduced the expression of MDA5, IPS-1, IRF-3, and NF-?B; their downstream inflammatory cytokines, IL-1?, IL-6, TNF-?, and IFN-?; and the protein levels of ..
  10. Kim K, Ku S, Lee K, Song C, An W. Muscle-protective effects of Schisandrae Fructus extracts in old mice after chronic forced exercise. J Ethnopharmacol. 2018;212:175-187 pubmed publisher
    ..PI3K) and muscle growth (A1R, TRPV4), while it downregulated mRNAs related to protein degradation (atrogin-1, MuRF1) and muscle growth inhibitor (myostatin, SIRT1)...
  11. Marino F, Risbridger G, Gold E. Activin-βC modulates cachexia by repressing the ubiquitin-proteasome and autophagic degradation pathways. J Cachexia Sarcopenia Muscle. 2015;6:365-80 pubmed publisher
    ..Western blot analysis for the specific E3 ubiquitin ligases, atrogin-1 and MuRF1, markers of the autophagic-lysosomal pathway, Beclin-1, p62, and LC3A/B, effectors Smad-2, Smad-3 and myostatin ..
  12. Vogelsang P, Karlsen M, Brun J, Jonsson R, Appel S. Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome. Arthritis Res Ther. 2014;16:R166 pubmed publisher
    ..Expression of Ro/Sjögren's syndrome-associated autoantigen A (Ro52/SSA), interferon regulatory factor 8 (IRF-8), Bim, signal transduction and activators of transcription (Stat) 1, p-Stat1 (Tyrosin 701), p-Stat1 (Serin 727), ..
  13. Xu X, Lai Q, Gu M, Liu D, Hou Q, Liu X, et al. Fish IRF3 up-regulates the transcriptional level of IRF1, IRF2, IRF3 and IRF7 in CIK cells. Fish Shellfish Immunol. 2015;47:978-85 pubmed publisher
    ..Phylogenetic tree analysis indicated that CiIRF3 gathers together with other IRF-3 from higher vertebrates in the same branch...
  14. Wang Y, Bettaieb A, Sun C, Deverse J, Radecke C, Mathew S, et al. Triglyceride-rich lipoprotein modulates endothelial vascular cell adhesion molecule (VCAM)-1 expression via differential regulation of endoplasmic reticulum stress. PLoS ONE. 2013;8:e78322 pubmed publisher
    ..Modulation of ER stress sensors also correlated with changes in expression of interferon regulatory factor 1 (IRF-1), a transcription factor of Vcam-1 responsible for regulation of its expression...
  15. Sanz Garcia C, Poulsen K, BELLOS D, Wang H, McMullen M, Li X, et al. The non-transcriptional activity of IRF3 modulates hepatic immune cell populations in acute-on-chronic ethanol administration in mice. J Hepatol. 2019;70:974-984 pubmed publisher
    ..that IRF3 also has critical non-transcriptional functions, including activating RIG-I-like receptors-induced IRF-3-mediated pathway of apoptosis (RIPA) and restricting activity of NF-κB...
  16. Xu Q, Jiang Y, Wangkahart E, Zou J, Chang M, Yang D, et al. Sequence and Expression Analysis of Interferon Regulatory Factor 10 (IRF10) in Three Diverse Teleost Fish Reveals Its Role in Antiviral Defense. PLoS ONE. 2016;11:e0147181 pubmed publisher
    Interferon regulatory factor (IRF) 10 was first found in birds and is present in the genome of other tetrapods (but not humans and mice), as well as in teleost fish...
  17. Huang Y, Yang M, Yu Y, Yang Y, Zhou L, Huang X, et al. Grouper TRIM13 exerts negative regulation of antiviral immune response against nodavirus. Fish Shellfish Immunol. 2016;55:106-15 pubmed publisher
    ..of EcTRIM13 not only negatively regulated the interferon promoter activity induced by interferon regulator factor (IRF) 3, IRF7, and melanoma differentiation-associated protein 5 (MDA5), but also decreased the expression of several ..
  18. Liu X, Huang K, Hou Q, Sun Z, Wang B, Lin G, et al. Identification and characterization of a constitutively expressed Ctenopharyngodon idella ADAR1 splicing isoform (CiADAR1a). Dev Comp Immunol. 2016;63:10-7 pubmed publisher
    ..CiADAR1a promoter is 1303 bp in length containing 4 IRF-Es. In the present study, we constructed pcDNA3...
  19. Zhu Y, Qi C, Shan S, Zhang F, Li H, An L, et al. Characterization of common carp (Cyprinus carpio L.) interferon regulatory factor 5 (IRF5) and its expression in response to viral and bacterial challenges. BMC Vet Res. 2016;12:127 pubmed publisher
    ..4-90.0 %) with other fish IRF5s and contains a DNA binding domain (DBD), a middle region (MR), an IRF-associated domain (IAD), a virus activated domain (VAD) and two nuclear localization signals (NLSs) similar to ..
  20. Zheng Z, Yang J, Jiang X, Liu Y, Zhang X, Li M, et al. Tick-Borne Encephalitis Virus Nonstructural Protein NS5 Induces RANTES Expression Dependent on the RNA-Dependent RNA Polymerase Activity. J Immunol. 2018;201:53-68 pubmed publisher
    ..TBEV NS5 appears to activate the IFN regulatory factor 3 (IRF-3) signaling pathway in a manner dependent on RIG-I/MDA5, which leads to the nuclear translocation of IRF-3 to bind ..
  21. Lussi C, Schweizer M. What can pestiviral endonucleases teach us about innate immunotolerance?. Cytokine Growth Factor Rev. 2016;29:53-62 pubmed publisher
    ..Hence, the viral non-structural protease N(pro) heads the transcription factor IRF-3 for proteasomal degradation, whereas an extracellularly secreted, soluble form of the envelope glycoprotein E(rns)..
  22. Dupré Aucouturier S, Castells J, Freyssenet D, Desplanches D. Trichostatin A, a histone deacetylase inhibitor, modulates unloaded-induced skeletal muscle atrophy. J Appl Physiol (1985). 2015;119:342-51 pubmed publisher
    ..However, TSA suppressed the rise in muscle-specific RING finger protein 1 (MuRF1) caused by unloading without affecting the forkhead box (Foxo3) transcription factor...
  23. Niu L, Chen Q, Hua C, Geng Y, Cai L, Tao S, et al. Effects of chronic dexamethasone administration on hyperglycemia and insulin release in goats. J Anim Sci Biotechnol. 2018;9:26 pubmed publisher
    ..markers of muscle atrophy, namely F-box protein 32 (FBXO32/Atrogin1) and muscle RING-finger protein 1 (MuRF1), was not altered by Dex...
  24. Dias Teixeira K, Calegari Silva T, Dos Santos G, Vitorino Dos Santos J, Lima C, Medina J, et al. The integrated endoplasmic reticulum stress response in Leishmania amazonensis macrophage infection: the role of X-box binding protein 1 transcription factor. FASEB J. 2016;30:1557-65 pubmed publisher
    ..proliferation associated with impaired translocation of phosphorylated IFN regulatory transcription factor (IRF)-3 to the nucleus and a decrease in IFN1-β expression...
  25. Homma S, Hayashi K, Yoshida K, Sagawa Y, Kamata Y, Ito M. Nafamostat mesilate, a serine protease inhibitor, suppresses interferon-gamma-induced up-regulation of programmed cell death ligand 1 in human cancer cells. Int Immunopharmacol. 2018;54:39-45 pubmed publisher
    ..of signal transducer and activator of transcription (STAT) 1 or the induction of interferon regulatory factor (IRF)-1 expression in IFN-gamma-treated HLC-1 cells...
  26. Thom C, Traxler E, Khandros E, Nickas J, Zhou O, Lazarus J, et al. Trim58 degrades Dynein and regulates terminal erythropoiesis. Dev Cell. 2014;30:688-700 pubmed publisher
    ..Thus, we propose that Trim58 promotes this process by eliminating dynein. Our findings identify an erythroid-specific regulator of enucleation and elucidate a previously unrecognized mechanism for controlling dynein activity. ..
  27. Grajales Reyes G, Iwata A, Albring J, Wu X, Tussiwand R, Kc W, et al. Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor. Nat Immunol. 2015;16:708-17 pubmed publisher
    ..of Irf8 became Batf3 dependent at a CD8α(+) cDC-specific enhancer with multiple transcription factor AP1-IRF composite elements (AICEs) within the Irf8 superenhancer...
  28. Kotla S, Gustin K. Proteolysis of MDA5 and IPS-1 is not required for inhibition of the type I IFN response by poliovirus. Virol J. 2015;12:158 pubmed publisher
    ..initiates a signal transduction pathway leading to activation of the transcription factors NF-κB, ATF-2 and IRF-3 that coordinately upregulate transcription of type I IFN genes, such as that encoding IFN-β...
  29. Wang F, Qiao L, Chen L, Zhang C, Wang Y, Wang Y, et al. The immunomodulatory activities of pullulan and its derivatives in human pDC-like CAL-1 cell line. Int J Biol Macromol. 2016;86:764-71 pubmed publisher
    ..nuclear factor kappa B (NF-κB) and the nuclear translocations of interferon regulation factors (IRFs), including IRF-3 and IRF-5, exhibited pivotal roles in the immune responses induced by pullulan, SUPL and AMPL...
  30. Lohse K, Bland M, Lang C. Quantifying Change During Outpatient Stroke Rehabilitation: A Retrospective Regression Analysis. Arch Phys Med Rehabil. 2016;97:1423-1430.e1 pubmed publisher
    ..time (days poststroke), age (y), and inpatient status (if the patient went to an inpatient rehabilitation facility [IRF]). A patient with average age and time started at 37 points on the BBS with a change of 1...
  31. Crossland H, Constantin Teodosiu D, Gardiner S, Greenhaff P. Peroxisome proliferator-activated receptor γ agonism attenuates endotoxaemia-induced muscle protein loss and lactate accumulation in rats. Clin Sci (Lond). 2017;131:1437-1447 pubmed publisher
    ..AKT and phosphorylated Forkhead box O (FOXO) 1 protein, as well as the up-regulation of muscle RING finger 1 (MuRF1; P<0.01) mRNA and the LPS-induced increase in 20S proteasome activity (P<0.05)...
  32. Liu C, Wang M, Chen M, Zhang K, Gu L, Li Q, et al. miR-18a induces myotubes atrophy by down-regulating IgfI. Int J Biochem Cell Biol. 2017;90:145-154 pubmed publisher
    ..Functional studies show that forced expression of miR-18a induces myotubes atrophy and increases the expression of MuRF1, Atrogin-1 and CTSL...
  33. Landgraf Rauf K, Boeck A, Raedler D, Klucker E, Vogelsang V, Schmidt S, et al. IRF-1 SNPs influence the risk for childhood allergic asthma: a critical role for pro-inflammatory immune regulation. Pediatr Allergy Immunol. 2017;: pubmed publisher
    ..While interferon regulating factor 1 (IRF-1) polymorphisms (SNPs) influence atopy risk, the effect of SNPs on asthma phenotype-specific immune mechanisms is ..
  34. Hayakawa N, Fukumura J, Yasuno H, Fujimoto Ouchi K, Kitamura H. 1α,25(OH)2D3 downregulates gene expression levels of muscle ubiquitin ligases MAFbx and MuRF1 in human myotubes. Biomed Res. 2015;36:71-80 pubmed publisher
    ..treatment significantly inhibited the expression of muscle atrophy F-box (MAFbx) and muscle RING finger 1 (MuRF1), ubiquitin ligases involved in muscle atrophy...
  35. Girgis C, Cha K, Houweling P, Rao R, Mokbel N, Lin M, et al. Vitamin D Receptor Ablation and Vitamin D Deficiency Result in Reduced Grip Strength, Altered Muscle Fibers, and Increased Myostatin in Mice. Calcif Tissue Int. 2015;97:602-10 pubmed publisher
    ..Vitamin D-deficient mice also showed increases in myostatin and the atrophy marker E3-ubiqutin ligase MuRF1. As a potential explanation for grip strength weakness, both groups of mice had down-regulation of genes encoding ..
  36. Ni M, Xu T, Wang Y, He Y, Zhou Q, Huang C, et al. Inhibition of IRF3 expression reduces TGF-β1-induced proliferation of hepatic stellate cells. J Physiol Biochem. 2016;72:9-23 pubmed publisher
    ..Interferon regulatory factor 3 (IRF3), one member of the interferon regulatory factor (IRF) family, is recently proven to be a critical modulator in cardiac fibrosis...
  37. Dang K, Li Y, Gong L, Xue W, Wang H, Goswami N, et al. Stable atrogin-1 (Fbxo32) and MuRF1 (Trim63) gene expression is involved in the protective mechanism in soleus muscle of hibernating Daurian ground squirrels (Spermophilus dauricus). Biol Open. 2016;5:62-71 pubmed publisher
    ..in the protein expression and activation states of Akt, mTOR and FoxO1 and the mRNA expression of atrogin-1 and MuRF1. Compared with the control groups, autumn and winter HU significantly lowered SOL muscle wet mass and muscle-to-..
  38. Mangner N, Bowen T, Werner S, Fischer T, Kullnick Y, Oberbach A, et al. Exercise Training Prevents Diaphragm Contractile Dysfunction in Heart Failure. Med Sci Sports Exerc. 2016;48:2118-2124 pubmed
    ..7 versus 26.7 ± 1.4 and 25.4 ± 1.4 N·cm, respectively (P < 0.05). Xanthine oxidase enzyme activity and MuRF1 protein expression, markers of oxidative stress and protein degradation, were ~20% and ~70% higher in sedentary HF ..
  39. Okpeku M, Esmailizadeh A, Adeola A, Shu L, Zhang Y, Wang Y, et al. Genetic Variation of Goat Interferon Regulatory Factor 3 Gene and Its Implication in Goat Evolution. PLoS ONE. 2016;11:e0161962 pubmed publisher
    ..The interferon regulatory factor (IRF) gene family control many different aspects of the innate and adaptive immune responses in vertebrates...
  40. Du K, Zhong Z, Fang C, Dai W, Shen Y, Gan X, et al. Ancient duplications and functional divergence in the interferon regulatory factors of vertebrates provide insights into the evolution of vertebrate immune systems. Dev Comp Immunol. 2018;81:324-333 pubmed publisher
    ..Using IRF HMM profile and HMMER searches, we identified 148 IRFs in 11 vertebrates and 4 protochordates...
  41. Dong V, Tu P, Tsai P, Lin Y, Chang H, Kuo T, et al. Expression of Toll-like receptor signaling-related genes in pigs co-infected with porcine reproductive and respiratory syndrome virus and porcine circovirus type 2. Res Vet Sci. 2015;101:180-6 pubmed publisher
    ..of TLR, including A20, Bcl-3, IRAK-M, MKP-1, SARM1 and SIGIRR, as well as the TLR downstream transcription factors IRF-1 and IRF-3...
  42. Kang C, Yeo D, Ji L. Muscle immobilization activates mitophagy and disrupts mitochondrial dynamics in mice. Acta Physiol (Oxf). 2016;218:188-197 pubmed publisher
    ..80% (P < 0.05 for 2w-IM; P < 0.01 for 3w-IM), along with activation of FoxO3a, atrogin-1 and MuRF1 following 2w- and 3w-IM (P < 0.01). Protein markers of autophagy/mitophagy, such as beclin 1 (approx. 2...
  43. Martinelli G, Olivari D, Re Cecconi A, Talamini L, Ottoboni L, Lecker S, et al. Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia. Oncogene. 2016;35:6212-6222 pubmed publisher
    ..and CXCR4 was inversely correlated with that of two ubiquitin ligases induced in muscle wasting, atrogin-1 and MuRF1, suggesting a possible clinical relevance of this pathway...
  44. Polak M, Ung C, Masapust J, Freeman T, Ardern Jones M. Petri Net computational modelling of Langerhans cell Interferon Regulatory Factor Network predicts their role in T cell activation. Sci Rep. 2017;7:668 pubmed publisher
    ..Applying Boolean logic we assembled a Petri net-based model of the IRF-GRN which provides molecular pathway predictions for the induction of different transcriptional programmes in LCs...
  45. Moskwa S, Piotrowski W, Marczak J, Pawełczyk M, Lewandowska Polak A, Jarzębska M, et al. Innate Immune Response to Viral Infections in Primary Bronchial Epithelial Cells is Modified by the Atopic Status of Asthmatic Patients. Allergy Asthma Immunol Res. 2018;10:144-154 pubmed publisher
    ..Gene expression of IFNs, chemokines, and IFN-regulatory factors (IRF-3 and IRF-7) was determined by using quantitative PCR...
  46. Senf S, Dodd S, Judge A. FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70. Am J Physiol Cell Physiol. 2010;298:C38-45 pubmed publisher
    ..Specifically, Hsp70 inhibited FOXO3a-induced promoter activation of atrogin-1, but not MuRF1. Further studies showed that a FOXO3a DNA-binding mutant can activate MuRF1, but not atrogin-1, suggesting that ..
  47. Awuh J, Haug M, Mildenberger J, Marstad A, Do C, Louet C, et al. Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages. Proc Natl Acad Sci U S A. 2015;112:E4272-80 pubmed publisher
    ..Keap1 knockdown led to increased nuclear translocation of transcription factors NF-κB, IFN regulatory factor (IRF) 1, and IRF5 driving the expression of inflammatory cytokines and IFN-β...
  48. Cao L, Ge X, Gao Y, Herrler G, Ren Y, Ren X, et al. Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-β production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathway. Virol J. 2015;12:127 pubmed publisher
    ..As the key IFN-β transcription factors, we found that dsRNA-induced activation of IFN regulatory factor 3 (IRF-3) was inhibited after PEDV infection, but not nuclear factor-kappaB (NF-κB)...
  49. Zhu D, Yang N, Liu Y, Zheng J, Ji C, Zuo P. M2 Macrophage Transplantation Ameliorates Cognitive Dysfunction in Amyloid-?-Treated Rats Through Regulation of Microglial Polarization. J Alzheimers Dis. 2016;52:483-95 pubmed publisher
    ..We observed an increased interferon regulatory factor (IRF) 5/IRF4 ratio, resulting in greater production of classically activated (M1) versus M2 microglia...
  50. Ramírez Carvajal L, Diaz San Segundo F, Ramirez Medina E, Rodriguez L, de Los Santos T. Constitutively Active IRF7/IRF3 Fusion Protein Completely Protects Swine against Foot-and-Mouth Disease. J Virol. 2016;90:8809-21 pubmed publisher
    ..studies have shown that a constitutively active fusion protein of porcine interferon (IFN) regulatory factors (IRF) 7 and 3 [IRF7/3(5D)] strongly induced type I IFN and antiviral genes in vitro and prevented mortality in an FMD ..
  51. Sun K, Wu Z, Ji Y, Wu G. Glycine Regulates Protein Turnover by Activating Protein Kinase B/Mammalian Target of Rapamycin and by Inhibiting MuRF1 and Atrogin-1 Gene Expression in C2C12 Myoblasts. J Nutr. 2016;146:2461-2467 pubmed
    ..rapamycin complex 1 (mTORC1), AMPK signaling, mRNA levels of atrogin-1 and muscle-specific ring finger protein 1 (MuRF1), and protein synthesis and degradation were measured in the absence or presence of an Akt inhibitor, LY294002, or ..
  52. Netherby C, Messmer M, Burkard Mandel L, Colligan S, Miller A, Cortes Gomez E, et al. The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production. J Immunol. 2017;198:4129-4139 pubmed publisher
    ..One integral player is IFN regulatory factor (IRF)-8, which promotes monocyte/dendritic cell differentiation while limiting granulocyte development...
  53. Zele A, Feigl B, Kambhampati P, Aher A, McKeefry D, Parry N, et al. A Temporal White Noise Analysis for Extracting the Impulse Response Function of the Human Electroretinogram. Transl Vis Sci Technol. 2017;6:1 pubmed publisher
    We introduce a method for determining the impulse response function (IRF) of the ERG derived from responses to temporal white noise (TWN) stimuli.
  54. Rengachari S, Groiss S, Devos J, Caron E, Grandvaux N, Panne D. Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function. Proc Natl Acad Sci U S A. 2018;115:E601-E609 pubmed publisher
    ..in the gene regulatory repertoire controlled by JAK/STAT signaling occurs through the interaction of STATs with IRF transcription factors to form ISGF3, a complex that contains STAT1, STAT2, and IRF9 and regulates expression of IFN-..
  55. Lee H, Kang K, Chung H, Kim H. Prognostic Factors for Functional and Anatomic Outcomes in Patients with Diabetic Macular Edema Treated with Dexamethasone Implant. Korean J Ophthalmol. 2018;32:116-125 pubmed publisher
    ..best-corrected visual acuity (BCVA), central macular thickness, and height and width of both intraretinal fluid (IRF) and subretinal fluid...
  56. Fu X, Li N, Lin Q, Guo H, Liu L, Huang Z, et al. Early protein ORF086 is an effective vaccine candidate for infectious spleen and kidney necrosis virus in mandarin fish Siniperca chuatsi. Fish Shellfish Immunol. 2015;46:200-5 pubmed publisher
    ..Transcriptional analysis of non-specific and specific immune related genes revealed that the expression levels of IRF-7, IRAK1, Mx, Viperin, and IgM were strongly up-regulated in the vaccinated groups post-immunization...
  57. Remesh S, Santosh V, Escalante C. Structural Studies of IRF4 Reveal a Flexible Autoinhibitory Region and a Compact Linker Domain. J Biol Chem. 2015;290:27779-90 pubmed publisher
    IRF4 is a unique member of the interferon regulatory factor (IRF) family playing critical regulatory roles in immune cell development, regulation of obesity-induced inflammation, and control of thermogenic gene expression...
  58. Rambow F, Job B, Petit V, Gesbert F, Delmas V, Seberg H, et al. New Functional Signatures for Understanding Melanoma Biology from Tumor Cell Lineage-Specific Analysis. Cell Rep. 2015;13:840-853 pubmed publisher
    ..The signature obtained was associated with phenotypic characteristics in vitro, and the core genes CAPN3 and TRIM63 were implicated in melanoma cell migration/invasion...
  59. Mao Y, Luo W, Zhang L, Wu W, Yuan L, Xu H, et al. STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity. Arterioscler Thromb Vasc Biol. 2017;37:920-929 pubmed publisher
    ..STING may be a potential therapeutic target for preventing cardiovascular diseases and insulin resistance in obese individuals. ..
  60. Ribeiro M, Guzzoni V, Hord J, Lopes G, Marqueti R, de Andrade R, et al. Resistance training regulates gene expression of molecules associated with intramyocellular lipids, glucose signaling and fiber size in old rats. Sci Rep. 2017;7:8593 pubmed publisher
    ..These responses were also linked to decreased catabolic (TNF-α, TWEAK/Fn14 axis; FOXO-1, Atrogin-1 and MuRF1; Myostatin) and increased anabolic intracellular pathways (IGF-1-mTOR-p70S6sk-1 axis; MyoD) in muscles of trained ..
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  64. Wan Q, Yang C, Rao Y, Liao Z, Su J. MDA5 Induces a Stronger Interferon Response than RIG-I to GCRV Infection through a Mechanism Involving the Phosphorylation and Dimerization of IRF3 and IRF7 in CIK Cells. Front Immunol. 2017;8:189 pubmed publisher
    ..CiMDA5 and CiRIG-I facilitate the expression and total phosphorylation levels of grass carp IFN regulatory factor (IRF) 3 (CiIRF3) and CiIRF7 upon GCRV infection or poly(I:C) stimulation...
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  67. Czerkies M, Korwek Z, Prus W, Kochanczyk M, Jaruszewicz Błońska J, Tudelska K, et al. Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways. Nat Commun. 2018;9:493 pubmed publisher
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    ..Furthermore, mRNA expression of immune related genes such as TNF-? (6.2-fold), IL-10 (5.0-fold), IL-12 (9.2-fold), IRF-1 (5.2-fold), Defbl1 (3-fold), Lyz (5...
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    ..Given previous evidence of MuRF2 interaction, we propose that the cellular role of TK is to act as a conformationally regulated scaffold that ..
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    ..In addition, DEX regulation of multiple genes, including two important atrophy markers, MuRF1 and MAFbx, is eliminated completely in the MGR(e3)KO mice...
  75. Seneviratne A, Edsfeldt A, Cole J, Kassiteridi C, Swart M, Park I, et al. Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis. Circulation. 2017;136:1140-1154 pubmed publisher
    ..The transcription factor interferon regulatory factor (IRF)-5 is an important modulator of myeloid function and programming...
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    ..The transcription factor interferon regulatory factor 1 (IRF-1) has a demonstrated role in shaping innate and adaptive antiviral immunity by inducing the expression of IFN-..
  77. Mearini G, Gedicke C, Schlossarek S, Witt C, Kramer E, Cao P, et al. Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms. Cardiovasc Res. 2010;85:357-66 pubmed publisher
    ..ligases, we investigated whether the muscle-specific E3 ligases atrogin-1 or muscle ring finger protein-1 (MuRF1) mediate degradation of truncated cMyBP-C...
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    ..II induces skeletal muscle atrophy in part by increased muscle-enriched E3 ubiquitin ligase muscle RING-finger-1 (MuRF1) expression, which may involve protein kinase D1 (PKD1)...
  79. Elkaim R, Bugueno Valdebenito I, Benkirane Jessel N, Tenenbaum H. Porphyromonas gingivalis and its lipopolysaccharide differently modulate epidermal growth factor-dependent signaling in human gingival epithelial cells. J Oral Microbiol. 2017;9:1334503 pubmed publisher
    ..is, EGF-receptor (EGFR), suppressor of cytokine signaling-3 (SOCS-3), interferon regulatory factor-1 (IRF-1), and signal transducers and activators of transcription (STAT-3)-are modified...
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    ..such as diabetes and starvation, a family of ubiquitin ligases, including muscle-specific RING-finger protein 1 (MuRF1), are induced to target muscle proteins for degradation via ubiquitination...
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    ..The role of the transcriptional factor interferon regulatory factor-5 (IRF-5) in endothelial physiology remains unknown...
  83. Vogl W, Waldstein S, Gerendas B, Schlegl T, Langs G, Schmidt Erfurth U. Analyzing and Predicting Visual Acuity Outcomes of Anti-VEGF Therapy by a Longitudinal Mixed Effects Model of Imaging and Clinical Data. Invest Ophthalmol Vis Sci. 2017;58:4173-4181 pubmed publisher
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    ..Interferon regulatory factor-8 (IRF-8), an important member in the IRF family, plays a key role in regulating the inflammation-related signaling ..
  85. Gröschel M, Sayes F, Shin S, Frigui W, Pawlik A, Orgeur M, et al. Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection. Cell Rep. 2017;18:2752-2765 pubmed publisher
    ..a low-virulence, ESX-1-proficient, recombinant BCG (BCG::ESX-1Mmar) that induces the cGas/STING/TBK1/IRF-3/type I interferon axis and enhances AIM2 and NLRP3 inflammasome activity, resulting in both higher proportions of ..
  86. Yang Q, Cui J, Song W, Zhao X, Xu T. The evolution and functional characterization of miiuy croaker interferon regulatory factor 9 involved in immune response. Fish Shellfish Immunol. 2017;66:524-530 pubmed publisher
    ..IRF9 is one of the IRF family gene members which belongs to the IRF4 subfamily...
  87. Pattwell S, Holland E. Putting Glioblastoma in Its Place: IRF3 Inhibits Invasion. Trends Mol Med. 2017;23:773-776 pubmed publisher
    ..New research suggests that altering a subset of extracellular matrix factors, including interferon regulatory factor (IRF)3 and casein kinase (CK)2, may decrease the migratory potential of these aggressive tumors.
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    ..not IL-1 beta, induced signal transducer and activator of transcription (STAT) 1 and interferon regulatory factor (IRF)-1 binding. In a -1...
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    ..Using loss-of-function approaches for various molecules, we demonstrate that the IRF-3-, IRF-5-, IRF-7-independent pathway predominantly utilizes IFN-? and, to a lesser degree, type I IFNs...
  90. Qi D, Chao Y, Liang J, Gao Q, Wu R, Mather I, et al. Adaptive evolution of interferon regulatory factors is not correlated with body scale reduction or loss in schizothoracine fish. Fish Shellfish Immunol. 2018;73:145-151 pubmed publisher
    ..We obtained 11 IRF genes (IRF1-11) from 14 of schizothoracine fish representing primitive, specialized, and highly specialized species,..
  91. White L, Wright K, Felix N, Ruffner H, Reis L, Pine R, et al. Regulation of LMP2 and TAP1 genes by IRF-1 explains the paucity of CD8+ T cells in IRF-1-/- mice. Immunity. 1996;5:365-76 pubmed
    ..In vivo footprinting indicates IFN gamma up-regulates protein-DNA contacts at an IRF-E that is essential for the up-regulation of TAP1 and LMP2 by IFN gamma...
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    ..In conclusion, muscle-specific E3 ubiquitin ligases were upregulated during cancer cachexia, and atrogin-1 may be a potential molecular target for treating muscle atrophy induced by cancer cachexia. ..