Gene Symbol: TRIM6
Description: tripartite motif containing 6
Alias: RNF89, tripartite motif-containing protein 6, RING finger protein 89, RING-type E3 ubiquitin transferase TRIM6
Species: human
Products:     TRIM6

Top Publications

  1. Zhang F, Hatziioannou T, Perez Caballero D, Derse D, Bieniasz P. Antiretroviral potential of human tripartite motif-5 and related proteins. Virology. 2006;353:396-409 pubmed
    ..However, endogenous owl monkey TRIMCyp potently inhibited an SIV(AGM) strain. Overall, sporadic examples of intrinsic antiretroviral activity exist in this panel of TRIM proteins...
  2. Li X, Gold B, O hUigin C, Diaz Griffero F, Song B, Si Z, et al. Unique features of TRIM5alpha among closely related human TRIM family members. Virology. 2007;360:419-33 pubmed
    ..TRIM5alpha turned over more rapidly than related TRIM proteins. TRIM5alpha, TRIM34 and TRIM6 associated with HIV-1 capsid-nucleocapsid complexes assembled in vitro; the TRIM5alpha and TRIM34 interactions ..
  3. Luijk R, Wu H, Ward Caviness C, Hannon E, Carnero Montoro E, Min J, et al. Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation. Nat Commun. 2018;9:3738 pubmed publisher
    ..Through cis-eQTL expression analysis, we map these loci to the genes SMCHD1/METTL4, TRIM6/HBG2, and ZSCAN9...
  4. Ju L, Lin X, Yan D, Li Q, Wu M, Li L. Characterization of WDR20: A new regulator of the ERAD machinery. Biochim Biophys Acta Mol Cell Res. 2018;1865:970-980 pubmed publisher
    ..We further confirmed four proteins, FBOX2, TRIM6, UFL1 and WDR20, are novel regulators for ERAD...
  5. Nenasheva V, Novosadova E, Makarova I, Lebedeva O, Grefenshtein M, Arsenyeva E, et al. The Transcriptional Changes of trim Genes Associated with Parkinson's Disease on a Model of Human Induced Pluripotent Stem Cells. Mol Neurobiol. 2017;54:7204-7211 pubmed publisher
    ..Moreover, the transcription of the trim6 and trim24 genes was different between cells, derived from PD patients, and control cells at all stages...
  6. Li X, Yeung D, Fiegen A, Sodroski J. Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins. J Biol Chem. 2011;286:27959-70 pubmed publisher
    ..These results support a model in which both ends of the core TRIM dimer (RING-B-box 2 at one end and Linker 2 at the other) contribute to the formation of higher order arrays. ..
  7. Mandell M, Jain A, Arko Mensah J, Chauhan S, Kimura T, Dinkins C, et al. TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. Dev Cell. 2014;30:394-409 pubmed publisher
    ..Thus, our study establishes that TRIMs can function both as regulators of autophagy and as autophagic cargo receptors, and reveals a basis for selective autophagy in mammalian cells. ..
  8. Yang Y, Brandariz Nu ez A, Fricke T, IVANOV D, Sarnak Z, Diaz Griffero F. Binding of the rhesus TRIM5? PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restriction. Virology. 2014;448:217-28 pubmed publisher
    ..that some human tripartite motif proteins bind the HIV-1 capsid but do not restrict HIV-1 infection, such as human TRIM6 and TRIM34...
  9. Bharaj P, Wang Y, Dawes B, Yun T, Park A, Yen B, et al. The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKK? Kinase-Mediated Type-I IFN Antiviral Response. PLoS Pathog. 2016;12:e1005880 pubmed publisher
    ..We previously showed that the E3-ubiquitin ligase TRIM6 catalyzes the synthesis of unanchored K48-linked polyubiquitin chains, which are not covalently attached to any ..

More Information


  1. Sato T, Okumura F, Ariga T, Hatakeyama S. TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells. J Cell Sci. 2012;125:1544-55 pubmed publisher
    ..In this study, we showed that tripartite motif containing 6 (TRIM6), one of the TRIM family ubiquitin ligases, was selectively expressed in ES cells and interacted with Myc followed ..
  2. Sawyer S, Emerman M, Malik H. Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals. PLoS Pathog. 2007;3:e197 pubmed publisher
    ..Here, we present an evolutionary comparison of the TRIM5 gene to its closest human paralogs: TRIM22, TRIM34, and TRIM6. We show that TRIM5 and TRIM22 have a dynamic history of gene expansion and loss during the evolution of mammals...
  3. Li X, Li Y, Stremlau M, Yuan W, Song B, Perron M, et al. Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. J Virol. 2006;80:6198-206 pubmed
    ..2(SPRY) domains. Here we investigated the abilities of domains from TRIM proteins (TRIM6, TRIM34, and TRIM21) that do not restrict HIV-1 infection to substitute for the domains of rhesus monkey ..
  4. Woo J, Imm J, Min C, Kim K, Cha S, Oh B. Structural and functional insights into the B30.2/SPRY domain. EMBO J. 2006;25:1353-63 pubmed
    ..2/SPRY domains, suggesting that these domains are protein-interacting modules, which recognize a specific individual partner protein rather than a consensus sequence motif. ..
  5. Rajsbaum R, Versteeg G, Schmid S, Maestre A, Belicha Villanueva A, Martínez Romero C, et al. Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKK? kinase-mediated antiviral response. Immunity. 2014;40:880-95 pubmed publisher
    ..However, the mechanism of IKK? activation upon IFN receptor signaling has remained elusive. Here we show that TRIM6, a member of the E3-ubiquitin ligase tripartite motif (TRIM) family of proteins, interacted with IKK? and promoted ..
  6. Orimo A, Tominaga N, Yoshimura K, Yamauchi Y, Nomura M, Sato M, et al. Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem. Genomics. 2000;69:143-9 pubmed
    ..These findings suggest that RNF21 is a downstream gene that may mediate interferon's biological action. ..
  7. Chauhan S, Kumar S, Jain A, Ponpuak M, Mudd M, Kimura T, et al. TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis. Dev Cell. 2016;39:13-27 pubmed publisher
    ..The cooperation between TRIM16 and Galectin-3 in targeting and activation of selective autophagy protects cells from lysosomal damage and Mycobacterium tuberculosis invasion. ..
  8. Bharaj P, Atkins C, Luthra P, Giraldo M, Dawes B, Miorin L, et al. The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication. J Virol. 2017;91: pubmed publisher
    ..We also found that VP35 interacts with TRIM6, a member of the E3-ubiquitin ligase tripartite motif (TRIM) family...