TRIM27

Summary

Gene Symbol: TRIM27
Description: tripartite motif containing 27
Alias: RFP, RNF76, RFP transforming protein, RING finger protein 76, ret finger protein, tripartite motif protein TRIM27, tripartite motif-containing 27, tripartite motif-containing protein 27
Species: human

Top Publications

  1. ncbi [Epidemiological study on factors affecting the hospitalization period of patients with active tuberculosis]
    Tadahiko Fujino
    Department of Respiratory Diseases, NHO Kanagawa National Hospital, 666 1, Ochiai, Hadano shi, Kanagawa 257 8585, Japan
    Kekkaku 83:567-72. 2008
  2. pmc ret transforming gene encodes a fusion protein homologous to tyrosine kinases
    M Takahashi
    Mol Cell Biol 7:1378-85. 1987
  3. ncbi Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities
    Yohei Shimono
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 278:51638-45. 2003
  4. ncbi PIAS proteins are involved in the SUMO-1 modification, intracellular translocation and transcriptional repressive activity of RET finger protein
    Tetsuo Matsuura
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Exp Cell Res 308:65-77. 2005
  5. ncbi Selective ablation of retinoblastoma protein function by the RET finger protein
    Maja Krützfeldt
    Centre for Cell and Molecular Biology, Chester Beatty Laboratories, 237 Fulham Road, SW3 6JB London, United Kingdom
    Mol Cell 18:213-24. 2005
  6. ncbi The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IkappaB kinase family members
    Jikun Zha
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, China
    J Immunol 176:1072-80. 2006
  7. pmc Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene
    M Takahashi
    Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Mol Cell Biol 8:1853-6. 1988
  8. ncbi RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions
    Y Shimono
    Departments of Pathology and Internal Medicine I, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 275:39411-9. 2000
  9. ncbi Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML
    T Cao
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston TX 77030, USA
    J Cell Sci 111:1319-29. 1998
  10. ncbi Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription
    Keiko Shimono
    Department of Pathology, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 280:39436-47. 2005

Detail Information

Publications207 found, 100 shown here

  1. ncbi [Epidemiological study on factors affecting the hospitalization period of patients with active tuberculosis]
    Tadahiko Fujino
    Department of Respiratory Diseases, NHO Kanagawa National Hospital, 666 1, Ochiai, Hadano shi, Kanagawa 257 8585, Japan
    Kekkaku 83:567-72. 2008
    ..We compared the time needed for sputum negative conversion of tubercle bacilli among patients with active tuberculosis to clarify factors affecting the hospitalization period...
  2. pmc ret transforming gene encodes a fusion protein homologous to tyrosine kinases
    M Takahashi
    Mol Cell Biol 7:1378-85. 1987
    ..The ret tyrosine kinase may thus represent a cell surface receptor which is expressed in a restricted range of human cells...
  3. ncbi Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities
    Yohei Shimono
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 278:51638-45. 2003
    ..beta have distinct transcriptional activities and bind to BRG1, a component of the SWI/SNF complex, and the RET finger protein (RFP), respectively...
  4. ncbi PIAS proteins are involved in the SUMO-1 modification, intracellular translocation and transcriptional repressive activity of RET finger protein
    Tetsuo Matsuura
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Exp Cell Res 308:65-77. 2005
    b>Ret finger protein (RFP) is a nuclear protein that is highly expressed in testis and in various tumor cell lines...
  5. ncbi Selective ablation of retinoblastoma protein function by the RET finger protein
    Maja Krützfeldt
    Centre for Cell and Molecular Biology, Chester Beatty Laboratories, 237 Fulham Road, SW3 6JB London, United Kingdom
    Mol Cell 18:213-24. 2005
    ..We present evidence here that the RET finger protein (RFP)/tripartite motif protein 27 (TRIM 27) inhibits gene transcription activation by Rb but does not affect ..
  6. ncbi The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IkappaB kinase family members
    Jikun Zha
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, China
    J Immunol 176:1072-80. 2006
    ..In yeast two-hybrid screens for potential IKKepsilon-interacting proteins, we identified Ret finger protein (RFP) as an IKKepsilon-interacting protein...
  7. pmc Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene
    M Takahashi
    Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Mol Cell Biol 8:1853-6. 1988
    ..This finger-containing gene may thus function in male germ cell development...
  8. ncbi RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions
    Y Shimono
    Departments of Pathology and Internal Medicine I, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 275:39411-9. 2000
    b>RET finger protein (RFP) belongs to the large B-box RING finger protein family and is known to become oncogenic by fusion with RET tyrosine kinase...
  9. ncbi Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML
    T Cao
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston TX 77030, USA
    J Cell Sci 111:1319-29. 1998
    The ret finger protein (rfp) is a member of the B-box zinc finger gene family many of which may function in growth regulation and in the appropriate context become oncogenic...
  10. ncbi Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription
    Keiko Shimono
    Department of Pathology, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 280:39436-47. 2005
    ..protein), we found that Mi-2beta, a component of a nucleosome remodeling and deacetylase (NuRD) complex, RET finger protein (RFP), and upstream binding factor (UBF) were associated with MCRS1...
  11. ncbi Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution
    T Cao
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Cell Sci 110:1563-71. 1997
    The ret finger protein (rfp) is a member of the B box zinc finger gene family which possesses a tripartite motif consisting of a RING finger, B box finger, and a coiled-coil domain...
  12. ncbi The Ret finger protein induces apoptosis via its RING finger-B box-coiled-coil motif
    So Hee Dho
    Laboratory of Functional Proteomics, Korea Research Institute of Bioscience and Biotechnology, Taejon 305 333, Korea
    J Biol Chem 278:31902-8. 2003
    The Ret finger protein (RFP) is a member of the tripartite motif family, which is characterized by a conserved RING finger, a B-box, and a coiled-coil domain (together called RBCC)...
  13. pmc SUMO E3 ligase activity of TRIM proteins
    Y Chu
    Department of Cancer Biology and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19096, USA
    Oncogene 30:1108-16. 2011
    ..Given the large number of TRIM proteins, our results may greatly expand the identified SUMO E3s. Furthermore, TRIM E3 activity may be an important contributor to SUMOylation specificity and the versatile functions of TRIM proteins...
  14. doi Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress
    Takuya Kato
    Department of Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Cancer Res 69:3597-604. 2009
    ..We found that the recruitment of HDAC1 to the TBP-2 promoter is mediated by a protein complex consisting of RET finger protein (RFP; also called TRIM27) and the trimeric transcription factor NF-Y...
  15. ncbi RFP represses transcriptional activation by bHLH transcription factors
    Adrian J C Bloor
    Department of Haematology, Cambridge Institute for Medical Research, Cambridge University, Hills Road, Cambridge CB2 2XY, UK
    Oncogene 24:6729-36. 2005
    ..Here we demonstrate for the first time that Ret finger protein (RFP), a member of the TRIM family of proteins initially identified as a recombined transforming gene from a ..
  16. ncbi [Isolation of MRSA from inpatients, staff and environment in the hospital]
    A Omori
    Department of Internal Medicine, Nagasaki University
    Kansenshogaku Zasshi 66:1396-403. 1992
    ..Concerning the drug sensitivity, many MRSA strains were highly resistant to DMPPC and FOM, but the sensitivity to RFP was 0.1 microgram/ml or less in all strains except for one highly resistant strain (200 micrograms/ml or above)...
  17. ncbi [Prospects for development of new antituberculous drugs]
    Haruaki Tomioka
    Department of Microbiology and Immunology, Shimane Medical University, 89 1, Enya cho, Izumo shi, Shimane 693 8501, Japan
    Kekkaku 77:573-84. 2002
    ..tuberculosis, which exhibit in vitro resistance to at least two major antituberculous drug (usually INH and RFP) and cause intractable TB, has greatly contributed to the increased incidence of TB...
  18. ncbi [Genetic evaluation for rifampicin-susceptibility of Mycobacterium tuberculosis]
    H Ohno
    Second Department of Internal Medicine, Nagasaki University School of Medicine
    Kansenshogaku Zasshi 71:323-8. 1997
    We evaluated the relationship between rifampicin (RFP)-susceptibility and genetic alterations in rpoB gene of clinically isolated Mycobacterium tuberculosis strains, collected from different geographic locations within Japan...
  19. ncbi Improvements to the hemagglutination inhibition test for serological assessment of recombinant fowlpox-H5-avian-influenza vaccination in chickens and its use along with an agar gel immunodiffusion test for differentiating infected from noninfected vaccina
    David E Swayne
    Southeast Poultry Research Laboratory, Agricultural Research Service, U S Department of Agriculture, 934 College Station Road, Athens, Georgia 30605, USA
    Avian Dis 51:697-704. 2007
    ..virus vaccine containing an H5 hemagglutinin gene from A/turkey/Ireland/83 (H5N8) avian influenza (AI) virus (rFP-H5) and evaluated for correlation of immunological response by hemagglutination inhibition (HI) or agar gel ..
  20. ncbi A new genetic assay for rifampicin susceptibility of Mycobacterium tuberculosis
    S Kusunoki
    Diagnostic Science Department, Shionogi and Co, Ltd, Osaka, Japan
    Kansenshogaku Zasshi 69:1342-7. 1995
    A new method for testing rifampicin (RFP) susceptibility of Mycobacterium tuberculosis was developed...
  21. ncbi [Leukopenia due to anti-tuberculous chemotherapy including rifampicin and isoniazid]
    Naohiro Nagayama
    Division of Respiratory Disease, National Organization Tokyo Hospital, 3 1 1, Takeoka, Kiyose shi, Tokyo 204 8585, Japan
    Kekkaku 79:341-8. 2004
    To examine the incidence rate by age and gender of leukopenia caused by chemotherapy including rifampicin (RFP) and isoniazid (INH), and to study the relationships between the leukopenia and the hepatic side effect or other ..
  22. ncbi Preparing a business justification for going electronic
    A Orlando Ortiz
    Radiology Department, Winthrop University Hospital, Mineola, New York, USA
    Radiol Manage 24:14-21. 2002
    ..A request for proposal (RFP) may facilitate this step...
  23. ncbi [External quality assessment of drug susceptibility testing for Mycobacterium tuberculosis]
    Satoshi Mitarai
    Bacteriology Division, Mycobacterium Reference Centre, Research Institute of Tuberculosis, JATA, 3 1 24, Matsuyama, Kiyose shi, Tokyo 204 8533, Japan
    Kekkaku 81:501-9. 2006
    ..The Committee for Mycobacterial Examinations has planned and implemented the third external quality assessment of drug susceptibility testing for Mycobacterium tuberculosis to the hospital and private laboratories...
  24. ncbi [Non-tuberculous mycobacteriosis. What has been coming out]
    Akira Kajiki
    Department of Respiratory Medicine, National Hospital Organization Ohmuta National Hospital, Fukuoka, Japan
    Kekkaku 86:113-25. 2011
    ..and Allergic Diseases) Mycobacterium avium complex (MAC) is refractory to therapy, containing rifampicin (RFP), ethambutol (EB), and clarithromycin (CAM)...
  25. ncbi [Drug-induced hepatotoxicity caused by anti-tuberculosis drugs in tuberculosis patients complicated with chronic hepatitis]
    Yugo Kaneko
    Department of Pulmonary Medicine, Jikei University School of Medicine, 4 11 1, Izumihoncho, Komae shi, Tokyo 201 8601, Japan
    Kekkaku 83:13-9. 2008
    ..incidence of drug-induced hepatitis (DIH) caused by antituberculosis drugs including isoniazid (INH), rifampicin (RFP), with and without pyrazinamide (PZA), and to evaluate risk factors for DIH in tuberculosis patients complicated ..
  26. ncbi [Treatment of non-tuberculous pulmonary mycobacteriosis]
    Mitsunori Sakatani
    National Hospital Organization Kinki chuo Chest Medical Center, 1180, Nagasone cho, Sakai shi, Osaka 591 8555, Japan
    Kekkaku 81:35-50. 2006
    ..The pulmonary diseases caused by M. kansasii or M. szulgai are usually treated by RFP, EB and INH, the same regimens with tuberculosis, which generally lead to sufficient results for patients...
  27. pmc Single molecule analysis of a red fluorescent RecA protein reveals a defect in nucleoprotein filament nucleation that relates to its reduced biological functions
    Naofumi Handa
    Departments of Microbiology, University of California, Davis, California 95616, USA
    J Biol Chem 284:18664-73. 2009
    ..RecA protein (RecA803 protein) to monomeric red fluorescent protein (mRFP1) to produce a functional protein (RecA-RFP) that is suitable for in vivo and in vitro analysis...
  28. ncbi Effects of lung surfactants on rifampicin release rate from monodisperse rifampicin-loaded PLGA microspheres
    Keishiro Tomoda
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Colloids Surf B Biointerfaces 55:115-24. 2007
    ..The effects of pulmonary surfactant on the rifampicin (RFP) release rate from RFP-loaded poly (lactide-co-glycolide) microspheres were studied...
  29. ncbi [Nosocomial infections due to methicillin-resistant S. aureus (MRSA) at the Kagoshima University Hospital (2). Susceptibility to antibiotics]
    J Nishi
    Department of Pediatrics, Faculty of Medicine, Kagoshima University
    Kansenshogaku Zasshi 65:1130-5. 1991
    ..The results were as follows: 1) Susceptibility of MRSA strains was excellent to VCM, MINO, and RFP, followed by IMP, CLDM, and CPFX...
  30. ncbi [Management of adverse effects with antituberculosis chemotherapy]
    Kazunari Tsuyuguchi
    National Hospital Organization Kinki chuo Chest Medical Center, 1180, Nagasone cho, Kita ku, Sakai shi, Osaka 591 8555, Japan
    Kekkaku 86:87-99. 2011
    ..As isoniazid (INH) and rifampicin (RFP) are key drugs for the cure, readministration of these drugs is often attempted by desensitization therapy...
  31. ncbi [Isolation of methicillin-resistant Staphylococcus aureus (MRSA) at the Hokusho Central Hospital--observation during the recent 4 years]
    H Mukae
    Department of Internal Medicine, Hokusyou Central Hospital
    Kansenshogaku Zasshi 64:1275-86. 1990
    ..4%). Patients with cerebrovascular disease were 55.9% of all of the cases. But most of the MRSA strains were resistant to CZX, FOM, DMPPC, CMX, CEZ, CZON, CZX, most of the MRSA strains were sensitive to RFP, VCM, MINO, IPM/CS.
  32. ncbi [Characteristics and treatment outcomes of INH-resistant or RFP-resistant tuberculosis]
    Wakana Saito
    Department of Respiratory Medicine, Tokyo National Hospital, 3 1 1, Takeoka, Kiyoseshi, Tokyo 204 8585, Japan
    Kekkaku 78:611-7. 2003
    ..In Japan the standard regimen has not been established even for INHr-TB, and the treatment has been done by each physician on the empirical bases...
  33. pmc Subcellular localization of ammonium transporters in Dictyostelium discoideum
    Janet H Kirsten
    Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, TN 37235 1634, USA
    BMC Cell Biol 9:71. 2008
    ....
  34. pmc Requirement of vasculogenesis and blood circulation in late stages of liver growth in zebrafish
    Svetlana Korzh
    Department of Biological Sciences, National University of Singapore, Singapore
    BMC Dev Biol 8:84. 2008
    ..In zebrafish, although it has been found that ECs are not required for liver budding, how and when the spatio-temporal pattern of liver growth is coordinated with ECs remains to be elucidated...
  35. doi Therapeutic effects of various initial combinations of chemotherapy including clarithromycin against Mycobacterium avium complex pulmonary disease
    Naoki Hasegawa
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Chest 136:1569-75. 2009
    ....
  36. pmc The Relationship between Characteristics of Home Care Nursing Service Contracts under Managed Competition and Continuity of Care and Client Outcomes: Evidence from Ontario
    Diane Doran
    Lawrence Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON
    Healthc Policy 2:97-113. 2007
    The purpose of this study was to investigate the impact of the Request for Proposal (RFP) process - specifically, the profit status of provider agencies awarded contracts, the service volume awarded and contract duration - on the quality ..
  37. ncbi Confocal fluorescence microscopy study of interaction between lens MIP26/AQP0 and crystallins in living cells
    Bing Fen Liu
    Ophthalmic Research Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biochem 104:51-8. 2008
    ..a donor and a crystallin (alphaA-, alphaB-, betaB2-, or gammaC-crystallin) tagged with a red fluorescence protein (RFP) as an acceptor. The two plasmids were cotransfected to HeLa cells...
  38. ncbi Efficacy of an inactivated and a fowlpox-vectored vaccine in Muscovy ducks against an Asian H5N1 highly pathogenic avian influenza viral challenge
    M Steensels
    Veterinary and Agrochemical Research Center, Groeselenberg 99, 1180 Ukkel, Belgium
    Avian Dis 51:325-31. 2007
    ..isolate A/chicken/Italy/22A/98 H5N9 (H5N9-It) was compared with that of the fowlpox-vectored TROVACTM-AIV H5 (rFP-AIV-H5) vaccine against an H5N1 highly pathogenic avian influenza challenge...
  39. ncbi [A case of pulmonary Mycobacterium fortuitum infection successfully treated with Kampo treatments]
    Tatsuya Nogami
    Department of Japanese Oriental Kampo Medicine, Aso Iizuka Hospital
    Kekkaku 81:525-9. 2006
    ..suffering from these symptoms since 1982, though the intensive anti-mycobacterial chemotherapy such as three-drug (RFP, SM, and INH), twice two-drug (KM and SM and cycloserine and enviomycin) and four-drug (CAM, EB, RFP, and KM) ..
  40. doi Rapid tip-directed movement of Golgi equivalents in growing Aspergillus nidulans hyphae suggests a mechanism for delivery of growth-related materials
    Michelle A Hubbard
    Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, SK S7N 5E2, Canada
    Microbiology 154:1544-53. 2008
    ..body/GE marker established in other systems, alpha-2,6-sialyltransferase, tagged with red fluorescent protein (ST-RFP). CopA-GFP and ST-RFP distributions responded similarly to brefeldin A, which impairs Golgi/GE trafficking...
  41. ncbi [Anti-tuberculosis chemotherapy]
    Masako Wada
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose shi, Tokyo
    Kekkaku 82:771-81. 2007
    ..Introduction of rifampicin (RFP) in 1966 and re-evaluation of pyrazinamide (PZA) in early 1970's have brought a revolutionary change in the concept ..
  42. ncbi 331 blood antigen-compatibility between cloned beagles and transgenic cloned beagles
    G A Kim
    Department of Theriogenology and Biotechnology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, South Korea
    Reprod Fertil Dev 23:261-2. 2011
    ..engineered from the same donor cell, BF3, although with the transfection of the red fluorescent protein (RFP) gene. All 6 beagles shared the same genetic background except for RFP gene insertion in their genome...
  43. pmc Specific residues of the influenza A virus hemagglutinin viral RNA are important for efficient packaging into budding virions
    Glenn A Marsh
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Virol 81:9727-36. 2007
    ..the deltaHA virus with an artificial segment containing green fluorescent protein (GFP) or red fluorescent protein (RFP) with HA packaging regions (45 3' and 80 5' nucleotides) partially restored the growth of this virus to wild-type ..
  44. pmc Interaction of Autographa californica multiple nucleopolyhedrovirus cathepsin protease progenitor (proV-CATH) with insect baculovirus chitinase as a mechanism for proV-CATH cellular retention
    Jeffrey J Hodgson
    Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Road East, Guelph, ON N1G 2W1, Canada
    J Virol 85:3918-29. 2011
    ..Furthermore, the CHIA-green fluorescent protein (GFP) and proV-CATH-red fluorescent protein (RFP) fusion proteins colocalize in the ER...
  45. ncbi [Survey of anti-tuberculosis drug-induced severe liver injury in Japan]
    Eriko Shigeto
    Department of Respiratory Medicine, National Hospital Organization, Higashihiroshima Medical Center, Hiroshima, Japan
    Kekkaku 82:467-73. 2007
    ..To clarify the incidence and clinical significance of anti-tuberculosis drug-induced liver injury...
  46. ncbi Breeding patterns of the JE vector Culex gelidus and its insect predators in rice cultivation areas of northern peninsular Malaysia
    A Abu Hassan
    School of Biological Sciences, Universiti Sains Malaysia, Penang
    Trop Biomed 27:404-16. 2010
    ..Six rice fields proper (RFP) and related drainage canals (DC) were visited through three cultivation cycles (CCs) over 17 months...
  47. doi The treatment of mice infected with multi-drug-resistant Mycobacterium tuberculosis using DNA vaccines or in combination with rifampin
    Yan Liang
    The Institute for Tuberculosis Research, the Second Affiliated Hospital of Chinese PLA General Hospital, Beijing 100091, China
    Vaccine 26:4536-40. 2008
    ..In this study, the effects of Ag85A DNA or ESAT6/Ag85A chimeric DNA vaccines alone or in combination with rifampin (RFP) were studied for the treatment of mice with MDR-TB...
  48. ncbi [Clinical efficacy of kanamycin for Mycobacterium avium complex disease]
    Ayumi Suzuki
    Course of Clinical Pharmacy, Graduate School of Pharmaceutical Science, Meiji Pharmaceutical University, Tokyo, Japan
    Yakugaku Zasshi 128:451-60. 2008
    No previous reports have compared clarithromycin (CAM), rifampicin (RFP) and ethambutol (EB) containing regimens with and without an aminoglycoside antibiotic kanamycin (KM) for the treatment of pulmonary Mycobacterium avium complex (MAC)..
  49. pmc The Arabidopsis small G protein ROP2 is activated by light in guard cells and inhibits light-induced stomatal opening
    Byeong Wook Jeon
    POSTECH UZH Global Research Laboratories, Division of Molecular Life Sciences, POSTECH, Pohang 790 784, Korea
    Plant Cell 20:75-87. 2008
    ..of Vicia faba expressing Arabidopsis thaliana constitutively active (CA) ROP2 fused to red fluorescent protein (RFP-CA-ROP2), fluorescence localized exclusively at the plasma membrane, whereas a dominant negative version of RFP-..
  50. doi Rifampicin-loaded liposomes for the passive targeting to alveolar macrophages: in vitro and in vivo evaluation
    Marco Zaru
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Cagliari, Cagliari, Italy
    J Liposome Res 19:68-76. 2009
    ..agents to macrophages, in this work we have prepared and characterized re-dispersible freeze-dried rifampicin (RFP)-loaded vesicles by using soy lecithin (SL) and a commercial, enriched mixture of soy phosphatidylcholine (..
  51. ncbi Function of the rfb gene cluster and the rfe gene in the synthesis of O antigen by Shigella dysenteriae 1
    J D Klena
    Department of Microbiology, Arizona State University, Tempe 85287
    Mol Microbiol 9:393-402. 1993
    ..DNA insert containing genes from the rfb cluster of Shigella dysenteriae 1 and a smaller insert containing the rfp gene from a S...
  52. pmc 52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart
    E K Chan
    W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037, USA
    J Exp Med 182:983-92. 1995
    ..Exon 7 is the longest and encodes the rfp-like domain and the 3' untranslated region...
  53. pmc How to satisfy both clinical and information technology goals in designing a successful picture archiving and communication system
    L C Beird
    Veterans Affairs Ann Arbor Healthcare System, MI 48105, USA
    J Digit Imaging 13:10-2. 2000
    ..This needs assessment needs to be made before issuing a request for proposal (RFP) and interviewing vendors. (3) The team needs to be small to be effective...
  54. ncbi Presumptive pre-Sertoli cells express genes involved in cell proliferation and cell signalling during a critical window in early testis differentiation
    Aron T Cory
    Faculty of Veterinary Medicine, University of Montreal, Saint Hyacinthe, Quebec, Canada
    Mol Reprod Dev 74:1491-504. 2007
    ..A mouse model expressing Red Fluorescent Protein (RFP) under the control of a hybrid mouse/pig SRY promoter (HybSRYp-RFP) was used to purify cells from embryonic day 12...
  55. doi Hansen's disease in Portugal: multibacillary patients treated between 1988 and 2003
    S Medeiros
    Dermatology Department, Curry Cabral Hospital, Lisbon, Portugal
    J Eur Acad Dermatol Venereol 23:29-35. 2009
    ..Patients were then treated with rifampicine (RFP), clofazimine (CLF) and dapsone (DDS) for a minimum of 2 years or until smear negativity...
  56. doi Posterior lateral hypothalamic axon terminals are in contact with trigeminal premotor neurons in the parvicellular reticular formation of the rat medulla oblongata
    Kazuki Notsu
    Department of Oral and Maxillofacial Surgery, Shimane University School of Medicine, Izumo 693 8501, Japan
    Brain Res 1244:71-81. 2008
    ..After cholera toxin B subunit (CTb) injection into the parvicellular reticular formation (RFp) of the rat medulla oblongata, where many trigeminal premotor neurons have been known to exist, numerous CTb-..
  57. ncbi Amygdaloid axon terminals are in contact with trigeminal premotor neurons in the parvicellular reticular formation of the rat medulla oblongata
    Yukihiko Yasui
    Department of Anatomy and Morphological Neuroscience, Shimane University School of Medicine, Izumo 693 8501, Japan
    Brain Res 1016:129-34. 2004
    ..were distributed bilaterally with a clear-cut ipsilateral dominance in the parvicellular reticular formation (RFp), where many CTb-labeled neurons existed bilaterally with slightly ipsilateral dominance...
  58. doi One-step preparation of rifampicin/poly(lactic-co-glycolic acid) nanoparticle-containing mannitol microspheres using a four-fluid nozzle spray drier for inhalation therapy of tuberculosis
    Katsuya Ohashi
    Laboratory of Pharmaceutics and Drug Delivery, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo, Japan
    J Control Release 135:19-24. 2009
    We prepared rifampicin (RFP)/poly(lactic-co-glycolic acid) (PLGA) nanoparticle-containing mannitol (MAN) microspheres for inhalation therapy of tuberculosis using a four-fluid nozzle spray drier in one step...
  59. ncbi Dobutamine echocardiography in idiopathic dilated cardiomyopathy: clinical and prognostic implications
    Bruno Pinamonti
    Department of Cardiology, Ospedale Maggiore, Piazza Ospedale 1, 34129, Trieste, Italy
    Eur J Heart Fail 4:49-61. 2002
    ..fraction (LVEF) with a peak value > or =40%, and a reversed restrictive left ventricular filling pattern (RFP) if present at baseline study...
  60. ncbi Efficacy of a fowlpox-vectored avian influenza H5 vaccine against Asian H5N1 highly pathogenic avian influenza virus challenge
    Michel Bublot
    Merial SAS, Discovery Research, Lyon 69007, France
    Avian Dis 51:498-500. 2007
    A recombinant fowlpox-avian influenza (AI) H5 vaccine (rFP-AIV-HS) expressing the hemagglutinin of the A/turkey/Ireland/1378/83 H5N8 AI isolate has been used in Central America since 1998 to control H5N2 low pathogenicity AI...
  61. ncbi Genotypic variability at the major histocompatibility complex (B and Rfp-Y) in Camperos broiler chickens
    G M Iglesias
    Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Buenos Aires, Argentina
    Anim Genet 34:88-95. 2003
    ..The MHC B haplotypes contribute resistance to Marek's and other diseases of economic importance. The Rfp-Y, a second cluster of MHC genes in the chicken, may also contribute to disease resistance...
  62. doi Generation of living color transgenic zebrafish to trace somatostatin-expressing cells and endocrine pancreas organization
    Zhen Li
    Department of Biological Sciences, National University of Singapore, Singapore 119260, Singapore
    Differentiation 77:128-34. 2009
    In the present study, both gfp and rfp transgenic zebrafish lines using a 2.5-kb zebrafish somatostatin2 (sst2) promoter were generated...
  63. ncbi Phagocytic activity of alveolar macrophages toward polystyrene latex microspheres and PLGA microspheres loaded with anti-tuberculosis agent
    Taizo Hasegawa
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Colloids Surf B Biointerfaces 60:221-8. 2007
    ..toward poly(lactic-co-glycolic acid) (PLGA) microspheres (MS) loaded with the anti-tuberculosis agent rifampicin (RFP-PLGA MS) has been shown to be effective for the treatment of tuberculosis...
  64. doi Investigation of a unique short open reading frame within the 3' untranslated region of the canine distemper virus matrix messenger RNA
    Dominique Wiener
    Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3001 Bern, Switzerland
    Virus Res 153:234-43. 2010
    ..An expression plasmid encoding the M2 ORF tagged both at its N-terminal (HA) and C-terminal domains (RFP), was first constructed...
  65. ncbi Projections from the red nucleus to the parvicellular reticular formation and the cervical spinal cord in the rat, with special reference to innervation by branching axons
    Y Yasui
    Department of Anatomy 2nd Division, Shimane Medical University, Izumo 693 8501, Japan
    Brain Res 923:187-92. 2001
    ..were distributed contralaterally in the lateral tegmental field including the parvicellular reticular formation (RFp), and ipsilaterally in the medial reticular formation...
  66. ncbi [Clinical analysis of drug interaction between rifampicin and clarithromycin which are used for treating pulmonary Mycobacterium avium complex infection]
    Hisashi Taki
    Department of Pharmacy, NHO Higashi Nagoya National Hospital, 5 101, Umemorizaka, Meito ku, Nagoya shi, Aichi 465 8620, Japan
    Kekkaku 82:641-6. 2007
    We reviewed the interaction between rifampicin (RFP) and clarithromycin (CAM) during treatment of pulmonary Mycobacterium avium complex infection.
  67. ncbi Intravenous ciprofloxacin versus erythromycin in the treatment of Legionella pneumonia
    Shusaku Haranaga
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Intern Med 46:353-7. 2007
    Erythromycin (EM) and rifampicin (RFP) have mainly been used to treat patients with Legionella pneumonia...
  68. pmc Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis
    Sixto M Leal
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Pathog 6:e1000976. 2010
    ..of the pathogenesis of Aspergillus keratitis, we developed a murine model in which red fluorescent protein (RFP)-expressing A. fumigatus (Af293...
  69. doi Do acute-phase reactants predict response to glucocorticoid therapy in retroperitoneal fibrosis?
    Marina N Magrey
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Arthritis Rheum 61:674-9. 2009
    ..the value of the erythrocyte sedimentation rate (ESR) and the C-reactive protein (CRP) level at the time of diagnosis for predicting radiographic response to glucocorticoid therapy in patients with retroperitoneal fibrosis (RFP).
  70. pmc Functions of Varicella-zoster virus ORF23 capsid protein in viral replication and the pathogenesis of skin infection
    Vaishali Chaudhuri
    Stanford University School of Medicine, 300 Pasteur Dr, S 354, Stanford, CA 94305, USA
    J Virol 82:10231-46. 2008
    ..Expression of ORF23 as a red fluorescent protein (RFP) fusion protein appeared to have a dominant negative effect on replication that was rescued by ORF23 expression ..
  71. ncbi Molecular behavior in living mitotic cells of human centromere heterochromatin protein HPLalpha ectopically expressed as a fusion to red fluorescent protein
    K Sugimoto
    Division ofApplied Biochemistry, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Sakai, Japan
    Cell Struct Funct 26:705-18. 2001
    ..heterochromatin protein HP1alpha and kinetochore protein CENP-A were differentially expressed as fusions to red (RFP-HP1) and green fluorescent proteins (GFP-CENP-A)...
  72. doi Determination of absolute size of fundus objects
    Jens Dawczynski
    Department of Ophthalmology, University Hospital Jena, Bachstr 18, 07749 Bachstraße 18, 07740, Jena, Germany
    Graefes Arch Clin Exp Ophthalmol 249:381-7. 2011
    Creating multiple beam interference fringes on the retina using the "retina fringe projector" (RFP) provides us with a scale which can be used to determine the absolute size of objects at the fundus.
  73. doi Novel strategy to selectively label excitatory and inhibitory neurons in the cerebral cortex of mice
    Kaustuv Basu
    Department of Psychiatry, Faculty of Medicine, Centre de Recherche Universite Laval Robert Giffard, 2601, chemin de la Canardiere, Quebec, G1J 2G3 Canada
    J Neurosci Methods 170:212-9. 2008
    ..We demonstrated in vitro and in vivo that GFP-expressing neurons are GABA-immunonegative (excitatory), while the RFP-expressing cells are either GABAergic neurons or glial cells...
  74. ncbi Restrictive filling pattern predicts pulmonary hypertension and is associated with increased BNP levels and impaired exercise capacity in patients with heart failure
    Ewa Straburzyńska-Migaj
    1st Department and Chair of Cardiology, Poznan University of Medical Sciences, Poland
    Kardiol Pol 65:1049-55; discussion 1056-7. 2007
    ..Severe diastolic dysfunction, which is defined as LV restrictive filling pattern (RFP), is associated with more severe HF, increased sympathetic activity and reduced exercise capacity...
  75. ncbi Transgenic mouse sperm that have green acrosome and red mitochondria allow visualization of sperm and their acrosome reaction in vivo
    Hidetoshi Hasuwa
    Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University
    Exp Anim 59:105-7. 2010
    ..mouse line whose sperm express green fluorescent protein (GFP) in their acrosome and red fluorescent protein (RFP) in their mitochondria [B6D2F1- Tg(CAG/su9-DsRed2, Acr3-EGFP)RBGS002Osb]...
  76. ncbi Cell culture and animal infection with distinct Trypanosoma cruzi strains expressing red and green fluorescent proteins
    S F Pires
    Departamento de Bioquimica e Imunologia, Instituto de Ciências Biológicas UFMG, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, 31270 901 Belo Horizonte, MG, Brazil
    Int J Parasitol 38:289-97. 2008
    ..an expression vector that allows the integration of green fluorescent protein (GFP) and red fluorescent protein (RFP) genes into the beta-tubulin locus by homologous recombination...
  77. pmc The retinoid signalling molecule, TRIM16, is repressed during squamous cell carcinoma skin carcinogenesis in vivo and reduces skin cancer cell migration in vitro
    Belamy B Cheung
    Children s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of NSW, Randwick, NSW, Australia
    J Pathol 226:451-62. 2012
    ..Overexpression of TRIM16 reduced SCC cell migration, which required the C-terminal RET finger protein (RFP)-like domain of TRIM16...
  78. pmc Post-mortem re-cloning of a transgenic red fluorescent protein dog
    So Gun Hong
    Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul 151 742, Korea
    J Vet Sci 12:405-7. 2011
    ..Fibroblasts from post-mortem red fluorescent protein (RFP) dog were reconstructed with in vivo matured oocytes and transferred into 10 surrogate dogs...
  79. ncbi [A new human cellular protein AUP1. III. The intracellular localization of AUP1 protein in different human and rat cell lines]
    K V Karpisheva
    Institute of Cytology RAS, St Petersburg, Russia
    Tsitologiia 44:846-51. 2002
    ..Additional studies with ectopically expressed AUP1, fused with red fluorescent protein (RFP) in H1299 and McG7 human cell lines and BRK1 rat cell line, showed cytoplasmic localization of RFP-AUP1...
  80. ncbi Color-coded real-time subcellular fluorescence imaging of the interaction between cancer and host cells in live mice
    Kensuke Yamauchi
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, California 92111, USA
    Anticancer Res 32:39-43. 2012
    ..in the nucleus with histone H2B-green fluorescent protein (GFP) and with retroviral red fluorescent protein (RFP) in the cytoplasm. HT-1080-GFP-RFP cells were sprinkled over a skin-flap in transgenic GFP immunocompetent mice...
  81. doi An effective gene-knockdown using multiple shRNA-expressing adenovirus vectors
    Yukari Motegi
    Department of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6, Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Control Release 153:149-53. 2011
    ..An application of the Ad-multi-shRNA vector carrying four same shRNA-sequences against the RET finger protein, an oncogene known to desensitize cells to oxidative stress and cisplatin, resulted in an enhanced cytotoxic ..
  82. doi A case of isoniazid-resistant miliary tuberculosis in which tuberculous meningitis paradoxically developed despite systemic improvement
    Satoshi Ikegame
    Department of Respiratory Medicine, National Hospital Organization Omuta National Hospital, 1044 1 Tachibana, Omuta, Fukuoka 837 0911, Japan
    J Infect Chemother 17:689-93. 2011
    ..He received anti-tuberculosis drugs: isoniazid (INH), rifampicin (RFP), ethambutol (EB), and pyrazinamide (PZA)...
  83. pmc Multi-targeted multi-color in vivo optical imaging in a model of disseminated peritoneal ovarian cancer
    Nobuyuki Kosaka
    National Institutes of Health, National Cancer Institute, Center for Cancer Research, Molecular Imaging Program, 10 Center Drive, Bethesda, Maryland 20892 1088, USA
    J Biomed Opt 14:014023. 2009
    ..Additionally, fusion tumors composed of SKOV3 and SHIN3/RFP were evaluated...
  84. pmc Heterogeneous ribonucleoprotein C displays a repressor activity mediated by T-cell intracellular antigen-1-related/like protein to modulate Fas exon 6 splicing through a mechanism involving Hu antigen R
    José M Izquierdo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, c Nicolas Cabrera 1, Lab 107, Cantoblanco, 28049 Madrid, Spain
    Nucleic Acids Res 38:8001-14. 2010
    ..This interaction also occurs in an RNA-dependent manner. Recombinant GFP-TIAR and RFP-hnRNP C1 proteins display partial nuclear co-localization when overexpressed in HeLa cells, and this requires the Q-..
  85. doi Adverse events and development of tuberculosis after 4 months of rifampicin prophylaxis in a tuberculosis outbreak
    S H Lee
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea
    Epidemiol Infect 140:1028-35. 2012
    ..We evaluated adverse events and TB incidence in all persons screened after rifampicin (RFP) prophylaxis, and specifically assessed the new TB cases in relation to initial TST and IGRA results...
  86. doi Generation of Recombinant Viral Hemorrhagic Septicemia Virus (rVHSV) Expressing Two Foreign Proteins and Effect of Lengthened Viral Genome on Viral Growth and In Vivo Virulence
    Min Sun Kim
    Department of Aquatic Life Medicine, Pukyong National University, Nam gu 599 1, Busan, 608 737, South Korea
    Mol Biotechnol 58:280-6. 2016
    In this study, a new recombinant VHSV (rVHSV-Arfp-Bgfp) was generated by insertion of a red fluorescent protein (RFP) gene between N and P genes, a green fluorescent protein (GFP) gene between P and M genes of VHSV genome, the expression ..
  87. doi Whole cell biosensing via recA::mCherry and LED-based flow-through fluorometry
    R L Martineau
    Harrington Department of Bioengineering, Arizona State University, Tempe, AZ 85287 9709, USA
    Biosens Bioelectron 25:759-66. 2009
    ..As reporter proteins, green fluorescent protein (GFP) and red fluorescent protein (RFP) were compared for suitability in the compact instrument. The RFP mCherry outperformed GFP (GFPmut3...
  88. ncbi [Identification of the authentic quality of Longdanxiegan pill by systematic quantified fingerprint method based on three wavelength fusion chromatogram]
    Guoxiang Sun
    College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    Se Pu 27:318-22. 2009
    ..According to the results of classification, the referential fingerprint (RFP) was synthesized from 10 batches of LDXGP...
  89. pmc Rhesus rhadinovirus infection of rhesus fibroblasts occurs through clathrin-mediated endocytosis
    Wei Zhang
    The University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Virol 84:11709-17. 2010
    ..Using a red fluorescent protein (RFP)-expressing recombinant RRV (RRV-RFP), we show that RRV particles are colocalized with markers of endocytosis (..
  90. doi Effect of lipophilicity on the bioavailability of drugs after percutaneous administration by dissolving microneedles
    Yukako Ito
    Department of Pharmacokinetics, Kyoto Pharmaceutical University, Yamashina ku, Kyoto 607 8412, Japan
    J Pharm Sci 101:1145-56. 2012
    ..ST), fluorescein (FL), granisetron (GRN), pindolol (PDL), pravastatin (PRV), rhodamine 123 (Rho), rifampicin (RFP), and salmeterol (SLM)...
  91. pmc Limited model antigen expression by transgenic fungi induces disparate fates during differentiation of adoptively transferred T cell receptor transgenic CD4+ T cells: robust activation and proliferation with weak effector function during recall
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA
    Infect Immun 80:787-97. 2012
    ..The addition of exogenous Eα-red fluorescent protein (RFP) to the Eα-mCh yeast boosted the number of cytokine-producing TEa cells that migrated to the lung...
  92. pmc Asparagine 175 of connexin32 is a critical residue for docking and forming functional heterotypic gap junction channels with connexin26
    So Nakagawa
    Institute for Protein Research, Osaka University, Suita, Osaka, Japan
    J Biol Chem 286:19672-81. 2011
    ..Our experimental data showed that Cx26-red fluorescent protein (RFP) and Cx32-GFP were able to traffic to cell-cell interfaces forming gap junction plaques and functional channels in ..
  93. doi A novel approach to determining the affinity of protein-carbohydrate interactions employing adherent cancer cells grown on a biosensor surface
    Diluka Peiris
    Department of Molecular and Applied Biosciences, School of Life Sciences, University of Westminster, 115 New Cavendish St, London W1W 6UW, England, UK
    Biosens Bioelectron 35:160-6. 2012
    ..agglutinin (HPA) has been shown to bind aggressive metastatic cancer and was produced in recombinant form (His- and RFP-tagged)...
  94. doi Single-molecule microscopy of molecules tagged with GFP or RFP derivatives in mammalian cells using nanobody binders
    Evgenia Platonova
    Randall Division of Cell and Molecular Biophysics, King s College London, SE1 1UL, United Kingdom Institute of Biochemistry, ETH Zurich, Zurich, Switzerland
    Methods 88:89-97. 2015
    ..Here we illustrate in detail how to use small, high affinity nanobody binders against GFP and RFP family proteins for highly generic labeling of fusion constructs with bright organic dyes...
  95. doi Characterization and differentiation potential of rabbit mesenchymal stem cells for translational regenerative medicine
    A Bakhtina
    Department of Biomedical Engineering, New Jersey Institute of Technology, University Heights, Newark, NJ, 07102, USA
    In Vitro Cell Dev Biol Anim 50:251-60. 2014
    ..In addition, the transduction efficiency of rbMSCs using a lentiviral vector with red fluorescent protein (RFP) as a method for labeling the cells for in vitro and in vivo use was also examined...
  96. pmc SAW1 is required for SDSA double-strand break repair in S. cerevisiae
    Graciel Diamante
    Department of Chemistry and Biochemistry, California State University Northridge, 18111 Nordhoff St, Northridge, CA 91330 8262, United States
    Biochem Biophys Res Commun 445:602-7. 2014
    ..The magnitude of induction of colocalized Saw1-CFP/Rad10-YFP/DSB-RFP foci in SDSA is more dramatic in S and G2 phase cells than in M phase, consistent with the known mechanism of SDSA...
  97. pmc Sorafenib-induced defective autophagy promotes cell death by necroptosis
    Pedram Kharaziha
    Department of Oncology Pathology, Cancer Centrum Karolinska, Karolinska Institutet and University Hospital, Stockholm, Sweden
    Oncotarget 6:37066-82. 2015
    ..the lack of cellular content in the autophagosomes, the accumulation of long-lived proteins, the presence of GFP-RFP-LC3 positive foci and the accumulated p62 protein levels indicate that these autophagosomes may not be fully ..
  98. pmc Osteosarcoma cells enhance angiogenesis visualized by color-coded imaging in the in vivo Gelfoam® assay
    Fuminari Uehara
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, California, 92111 Department of Surgery, University of California, 200 West Arbor Drive, San Diego, California, 92103 Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0125, Japan
    J Cell Biochem 115:1490-4. 2014
    ..143B osteosarcoma cells expressing green fluorescent protein (GFP) in the nucleus and red fluorescent protein (RFP) in cytoplasm were injected into the transplanted Gelfoam®. The control-group mice had only implanted Gelfoam®...
  99. pmc Anti-interleukin-6 therapy through application of a monogenic protein inhibitor via gene delivery
    Dieter Görtz
    Institute of Biochemistry and Molecular Biology, RWTH Aachen University, Aachen, Germany
    Sci Rep 5:14685. 2015
    ..Here, we engineered and characterized a receptor fusion protein, mIL-6-RFP-Fc, for the inhibition of interleukin-6 (IL-6), a well-established target in anti-cytokine therapy...
  100. ncbi Ratiometric fluorescence polarization as a cytometric functional parameter: theory and practice
    Yitzhak Yishai
    The Biophysical Interdisciplinary Jerome Schottenstein Center for the Research and the Technology of the Cellome, Department of Physics, Bar Ilan University, Ramat Gan 52900, Israel
    Phys Med Biol 48:2255-68. 2003
    The use of ratiometric fluorescence polarization (RFP) as a functional parameter in monitoring cellular activation is suggested, based on the physical phenomenon of fluorescence polarization dependency on emission wavelengths in multiple ..
  101. doi Influence of Food on Rifampicin Pharmacokinetics in Rats
    Hitoshi Shimomura
    Faculty of Pharmaceutical Sciences, Tokyo University of Science
    Biol Pharm Bull 39:49-53. 2016
    Rifampicin (RFP; 30 mg/kg) was orally administered to fasted or fed rats using ultrapure water as the vehicle, and the influence of food on its pharmacokinetics was investigated...

Research Grants66

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  3. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..Pursuant to that mission, the National Institute of Environmental Health Sciences (NIEHS) released the RFP topic stating their objective and mission that "human health and human disease result from three interactive ..
  4. Endoplasmic reticulum structure and dynamics in breast cancer cell metastasis and
    JASON EDWARD LEE; Fiscal Year: 2013
    ..of breast cancer cells with GFP-tagged focal adhesion proteins (integrin-[unreadable]3 or PTP1B) and RFP-KDEL (ER marker) will be used to visualize ER tubule-associated delivery of these proteins to focal adhesions, and ..
  5. Mammary Gland Morphogenesis and Breast Cancer
    Ian G Macara; Fiscal Year: 2013
    ..The viruses also express a red fluorescent protein. RFP-positive lung metastases will be isolated and screened by PCR to identify the cDNA associated with each metastatic ..
  6. Intravenous Protein Therapy for Treatment of Congenital Muscular Dystrophy
    Bradley L Hodges; Fiscal Year: 2010
    ..We have prepared and distributed a request for proposal (RFP) to various contract manufacturing organizations (CMO) for the production of large quantities of GLP-grade of the ..
  7. Therapeutic Immunoregulation Mediated by TGF-beta-induced iTregs in Autoimmune Ar
    Song Guo Zheng; Fiscal Year: 2013
    ..nTreg or iTregs will be sorted or induced from DBA/1 Foxp3-GFP knock-in mice or Foxp3-GFP/IL-17-RFP double knock-in mice...
  8. Color-Coded Imaging of Pancreatic Cancer Microenvironment for Drug Discovery
    Meng Yang; Fiscal Year: 2013
    ..in which nascent blood vessels are labeled with GFP and tumors are labeled with red fluorescent protein (RFP)...
  9. IN VIVO VISUALIZATION AND QUANTIFICATION OF EPIGENETIC ACTIVITIES USING MAGNETIC
    Won Bin Young; Fiscal Year: 2011
    ..We will use both ferritin and CD/fluorine as MRI reporters along with optical markers (GFP/RFP) to visualize and quantify DNMT1 gene expression in mouse models...
  10. Interplay Between Pathogenic and Regulatory T Cells in EAE
    Estelle Bettelli; Fiscal Year: 2012
    ..We have generated an IL-17F RFP/DTR mouse in which Th17 cells can be deleted at any given time through the injection of diphtheria toxin and we ..
  11. MULTIPHOTON CONFOCAL MICROSCOPE
    Liza A Pon; Fiscal Year: 2010
    ..g. YFP, RFP, DiI), 2) multicolor exci- tation, 3) detection of weaker signals, and 4) imaging thicker samples (>100-200 5m)...
  12. CCR2 in Hematopoietic Stem Cell Homing, Macrophage Polarization and Organ Repair
    Israel F Charo; Fiscal Year: 2013
    ..Using novel CCR2/RFP knock-in mice, we will quantify the expression of CCR2 on HSCs/HPCs in all branches of the hematopoietic tree in ..
  13. Pregnancy Risk Assessment Monitoring System (PRAMS)
    Murray L Katcher; Fiscal Year: 2013
    ..CDC) for the Pregnancy Risk Assessment Monitoring System (PRAMS) Funding Opportunity Announcement Number: RFP- DP-11-001, U01, and Category B - Existing State programs...
  14. Innovative In Vivo-like Model for Vascular Tissue Engineering
    Eva Schmelzer; Fiscal Year: 2013
    ..b>RFP transfection labeled progenitors (hemangioblasts and angioblasts) and non-endothelial fetal liver cells will be ..
  15. Development of a HTS assay for modulators of presenilin 1 conformation
    Oksana Berezovska; Fiscal Year: 2010
    ..We have recently developed a novel molecular reporter probe, GFP-PS1-RFP (G-PS1-R), which allows monitoring intra-molecular interactions in intact and/or live cells...
  16. NON-CELL AUTONOMOUS EFFECTS IN MAMMARY CANCER
    JO ANNE MARIE MONTALBANO; Fiscal Year: 2010
    ..cells impact the phenotype of transformed cells? I will transduce mammary stem cells with lentivirus expressing a RFP-Ras fusion and mix them at a low concentration with stem cells expressing GFP-Histone H2A, and transplanted into a ..
  17. Generating molecular markers that selectively label urothelial sub-populations
    CATHY LEE MENDELSOHN; Fiscal Year: 2013
    ..beginning with those that we have defined using transgenic and lineage-tagged mouse models expressing RFP or GFP...
  18. Differential regulation of autoimmune arthritis by monocyte subsets
    Peng Liu; Fiscal Year: 2013
    ..this hypothesis by combined in vitro and in vivo approaches including isolating monocyte subsets from GFP- or RFP- reporter mice, de novo differentiations of Th17 cells and regulatory T cells (Tregs), transendothelial migration ..
  19. Utilizing PB Transposon to Generate a Comprehensive Mouse Knockout Resource
    Tian Xu; Fiscal Year: 2009
    ..pB can carry large DNA fragments, e.g., an Act-RFP marker and a LacZ reporter, which can report gene expression patterns;6...
  20. CCR2 in Atherosclerosis and Monocyte Trafficking
    Israel F Charo; Fiscal Year: 2010
    ..Using novel CCR2-RFP knock-in mice and MCP-1/MCP-3 lac-Z reporter mice, we will test the hypothesis that CCR2 mediates selective ..
  21. Green Housing Study: Boston Followup
    Gary Adamkiewicz; Fiscal Year: 2013
    ..As stated in the RFP, the specific aims of the GHS are as follows: Specific Aim 1 To conduct an exposure assessment of chemical and ..
  22. The Role of Monocytes and Microglia in Traumatic Brain Injury-Induced Tauopathies
    Richard M Ransohoff; Fiscal Year: 2013
    ..of MAPT pathologies following TBI utilizing unique genetic models that fluorescently tag monocytes (CCR2-RFP) and microglia (CX3CR1-GFP), genomic-based mouse models of MAPT (hTau) pathologies and genetic models in which ..
  23. GDNF/Ret Regulation of Ureteric Bud Morphogenesis
    ADAM I PACKARD; Fiscal Year: 2012
    ..In addition, we co-express a red fluorescent protein (RFP), along with Ret, which allows us to follow the behavior of these manipulated cells using time-lapse microscopy, ..
  24. In situ Protein-Protein Interaction Networks (PIN) of Neurons
    Akira Chiba; Fiscal Year: 2010
    ..inducible transgenic lines for neurologically 'relevant'proteins tagged with either GFP or monomeric RFP (red fluorescent protein)...
  25. Rapid Estimation of Influenza Vaccine Effectiveness in a Wisconsin Population Coh
    Edward Belongia; Fiscal Year: 2010
    ..To meet optional Objective 5 in the RFP, we will recruit a stratified random sample of elderly, non-institutionalized cohort members (65 years old) for ..
  26. The immunological mechanism of PGRNs anti-inflammatory effect
    Chuanju Liu; Fiscal Year: 2013
    ..insight into the mechanisms of already known therapies of PGRN, we will use IL-10-GFP reporter tiger mice and Foxp3 RFP reporter FIR mice to identify the IL-10 expressing non-Treg cells and Treg cells in response to gain- or loss-of- ..
  27. Localization of Recombination sites in E. coli
    Steven J Sandler; Fiscal Year: 2010
    ..These reagents include RecA-GFP, SSB-GFP and sulAp-gfp. Similar reagents: RecA-YFP, SSB-CFP and sulAp-rfp (yellow, cyan and red fluorescent proteins respectively) will be built so that one can measure all three at once in ..
  28. The Role of Inflammation and Stroma in Digestive Cancer
    TIMOTHY CRAGIN WANG; Fiscal Year: 2010
    ..g. INS-GAS), reporter gene mice (ASMA-RFP/COLL-EGFP/Luc) targeting myofibroblasts, and a new method of methylation-sensitive SNP chip analysis (MSNP) to ..
  29. TRIM27 is a new negative regulator of CD4 T cells and Mast cells.
    Edward Y Skolnik; Fiscal Year: 2013
    ..1. We identified the Tripartate Motif containing protein 27 (TRIM27) as a new negative regulator of PI3K-C2[unreadable] and KCa3.1...
  30. Role of Pattern Recognition Receptors in Protection Against Influenza Virus
    Balaji Manicassamy; Fiscal Year: 2011
    ..antagonist NS1 in limiting host immune response and viral pathogenesis, using the recently generated influenza GFP/RFP reporter viruses...
  31. Endothelial Plasticity in Human Disease
    Damian Medici; Fiscal Year: 2013
    ..We propose to produce doxycycline inducible wild-type and mutant (constitutively active) ALK2-RFP transgenic mice that will be crossed with VE-Cadherin-Cre;Rosa26-rtTA-EGFP mice in order to selectively induce and ..
  32. Targeting trinucleotide repeats-induced transcriptional silencing in Friedreich's
    Marek Napierala; Fiscal Year: 2011
    ..We will also develop selectivity assay using an independent reporter red fluorescent protein (RFP) minigene without GAA repeats. (ii) Configuration of the assay for a high-throughput screen...
  33. Pref-1 function and regulation in adipogenesis
    Hei Sook Sul; Fiscal Year: 2013
    ..characterize Pref-1 expressing adipose precursor cells, we will generate Pref-1- reporter mice that express GFP and RFP in an inducible manner...
  34. Role of Pattern Recognition Receptors in Protection Against Influenza Virus
    Balaji Manicassamy; Fiscal Year: 2013
    ..antagonist NS1 in limiting host immune response and viral pathogenesis, using the recently generated influenza GFP/RFP reporter viruses...
  35. Novel assay for functional capacities of pluripotent stem cells
    ROGER ARNOLD PEDERSEN; Fiscal Year: 2013
    ..green fluorescent protein (GFP) reporter gene as well as a conditionally expressed red fluorescent protein (RFP) reporter gene...
  36. Discovering cardiomyopathy modifiers in TOR signaling via zebrafish genetics
    Xiaolei Xu; Fiscal Year: 2013
    ..adapted a transposon-based insertional mutagenesis strategy that facilitates the identification of all mutants by a RFP tag...
  37. Establishing and characterizing BAFF RFP reporter and BAFF knockin mice
    Edward A Clark; Fiscal Year: 2013
    ..We have two Aims: Aim 1. Generation of BAFF-RFP reporter and BAFF/BLyS knockin (KI) mice...
  38. FY 2013 SBIR-I Contract for Automated Instrument to Clean Microtiter Plates
    PAUL HENSLEY; Fiscal Year: 2013
    ..may be readily integrated to create an instrument designed to meet the specifications defined by the NCATS Contract RFP. ii) B1-Microtiter plates commonly used for high throughput screening include 96 well (8x12), 384 well (16x24) or ..
  39. Integrated FMT approaches for biomolecular measurements
    Ralph Weissleder; Fiscal Year: 2013
    ..discovery of two new reporter probe platforms (upconverting nanoparticles (UNP) and far red fluorescent proteins, RFP) are likely to have considerable impact...
  40. Evaluation of the cutaneous microbiome in psoriasis
    Martin J Blaser; Fiscal Year: 2011
    ..Since causality is complex and often difficult to prove, and beyond the scope of this RFP, our overall hypothesis is that there are alterations in the cutaneous microbiome in areas of skin affected by ..
  41. Appalachian Regional Informatics Consortium (ARIC)Planning Project
    Brian Phillips; Fiscal Year: 2005
    ..The technical planning document will establish the criteria to create a Request for Proposal (RFP) to be submitted to potential developers and vendors...
  42. Customized Nanofiltration Membranes for Enhancing Pharmaceutical Manufacturing
    KENNETH J PENNISI; Fiscal Year: 2011
    ..This is also responsive to NIH RFP PA-09-100 entitled "Energy Efficiency and Renewable Energy System Technology Research &Development"...
  43. FORE-SCI TRAINING PROGRAM (RFP 08-01)
    DANA MCTIGUE; Fiscal Year: 2011
    ..abstract_text> ..
  44. FORE-SCI TRAINING PROGRAM (RFP 08-01)
    Dana M McTigue; Fiscal Year: 2009
    ..abstract_text> ..
  45. FORE-SCI TRAINING PROGRAM (RFP 08-01)
    DANA MCTIGUE; Fiscal Year: 2012
    ..abstract_text> ..
  46. TAS::75 0903::TAS RECOVERY ACT CONTRACT ACTION - PROVIDING RADIOLOGIC OUTCOMES F
    JOYCE ABE; Fiscal Year: 2010
    ..As noted in the RFP, the OAI cohort study is a publicly available database of baseline and annual follow-up assessments in 4,796 ..
  47. PRECLINICAL EVAL. OF THERAPIES FOR MICROSPORIDIAL INFECT
    ELIZABETH DIDIER; Fiscal Year: 2000
    ..This RFP represents a segment of the Opportunistic Infections Research Branch's drug discovery and development program, ..
  48. EFFICACY TRIAL OF AN ACELLULAR PERTUSSIS VACCINE
    Donato Greco; Fiscal Year: 2000
    ..Sites were developed in Canada, Italy and Sweden following a Part I award September 30, 1990 in response to RFP 90-30...
  49. Computational Investigations of Monomeric Variants of Red Fluorescent Proteins
    Prem P Chapagain; Fiscal Year: 2013
    ..Structural modifications to these RFPs have produced monomeric RFP variants, but at present their usefulness is limited because they are not photostable...
  50. Targeted tumoricidal bacteria
    Ming Zhao; Fiscal Year: 2007
    ..imaging systems that enable the visualization of green fluorescent protein (GFP)- and red fluorescent protein (RFP)- expressing tumors and bacteria (Nature Reviews Cancer 5, 796-806, 2005; Proc. Natl. Acad. Sci...
  51. PDK1 and PPARdelta Signaling in Mammary Tumorigenesis
    Robert I Glazer; Fiscal Year: 2010
    ..will be studied by fluorescent confocal microscopic imaging of live tumor cells expressing PDK1-GFP and PPAR<5-RFP. Aim #3: Determine the genetic consequences and tumorigenic effects of PDK1 and PPARrf expression in the mammary ..
  52. Molecular Modulators of Breast-Bone Metastasis
    John Price; Fiscal Year: 2004
    ..These sublines have previously been stably transfected with a construct that expresses red fluorescent protein (RFP) to allow full fluorescent body imaging of metastases in the in vivo bone metastatic models...
  53. Divalent cation activation of the integrin-mediated malignant phenotype in pancre
    Michael Bouvet; Fiscal Year: 2010
    ..Aim: We will utilize our red fluorescent protein orthotopic mouse model, in which cancer cells are labeled with RFP, to examine the use of divalent cations as surgical adjuvant therapy during pancreatic cancer resection and as ..
  54. Corneal HSV-1: Immunopathologic Mechanisms of HSK
    Steven L Wechsler; Fiscal Year: 2010
    ..GFP, YFP, RFP tagged CJLAT and wt viruses will also be employed. 3...
  55. Imageable tumor-targeting bacteria
    Ming Zhao; Fiscal Year: 2006
    ..imaging systems that enable the visualization of green fluorescent protein (GFP)- and red fluorescent protein (RFP)-expressing tumors and bacteria (Lancet Oncology 3, 546-556, 2002; Proc. Natl. Acad. Sci. USA 98, 9814-9818, 2001)...
  56. NORTH CENTRAL APPALACHIA BREAST CANCER EDUCATION SUMMIT
    Paul Brown; Fiscal Year: 1993
    ..An RFP will be distributed at the Summit to encourage community coalitions to submit a proposal to hold a follow-up summit ..
  57. A Lymphatic-specific fluorescent transgenic model
    Young Kwon Hong; Fiscal Year: 2007
    ..Here, we propose the generation of a transgenic mouse line that expresses the red fluorescent protein (RFP) specifically in the lymphatic system. We plan to achieve this goal by undertaking 2 separate approaches...
  58. A High Content Screen to Identify Inhibitors of MT1-MMP Activation
    Vladislav Golubkov; Fiscal Year: 2013
    ..of the MT1- MMP prodomain we used the prodomain sequence to generate the fluorescent biosensors (the cleavable RFP-PRO-GFP and the uncleavable RFP-L50D-GFP control)...
  59. Animal Models as Surrogates, SBIR Phase I [unreadable] RFP No. PHS 2010-1 Topic #13
    CHARLES MAGNESS; Fiscal Year: 2011
    ..Kineta, Inc. will develop a drug surrogate Ontology that will be integrated into existing NCRR-supported resources to provide tools and explicitly support drug discovery. ..
  60. SUCCIMER REDUCTION OF TISSUE PB AND TOXICITY
    NELLIE LAUGHLIN; Fiscal Year: 2000
    ..The proposed studies, which parallel recently initiated pediatric human clinical trials (RFP NIH-ES 92-32), will use the rhesus monkey as a well-established, nonhuman primate model of childhood lead exposure...
  61. Confocal Live Cell Imaging Instrument
    WILLIAM KINSEY; Fiscal Year: 2004
    ..Dr. Godwin will require the ability to image GFP and RFP constructs in living zebrafish embryos. Drs...
  62. TAS::75 0872::TAS SMARTT (11-8470187)
    Hanna Ng; Fiscal Year: 2013
    In response to Request of Proposal (RFP), NHLBI-HV-1 0-11, SRI International (SRI, formerly Stanford Research Institute) proposes to act as a flexible and responsive resource contractor as the Pharmacology and Toxicology Center (PTC) to ..
  63. TAS::75 0872::TAS SMARTT (11-8470187)
    Hanna Ng; Fiscal Year: 2012
    In response to Request of Proposal (RFP), NHLBI-HV-1 0-11, SRI International (SRI, formerly Stanford Research Institute) proposes to act as a flexible and responsive resource contractor as the Pharmacology and Toxicology Center (PTC) to ..
  64. TAS::75 0872::TAS SMARTT (11-8470187)
    Hanna Ng; Fiscal Year: 2011
    In response to Request of Proposal (RFP), NHLBI-HV-1 0-11, SRI International (SRI, formerly Stanford Research Institute) proposes to act as a flexible and responsive resource contractor as the Pharmacology and Toxicology Center (PTC) to ..
  65. A KNOCK-IN MOUSE FOR MARKING AND ISOLATION OF ALPHA-GUST
    Sami Damak; Fiscal Year: 2003
    ..these shortfalls of the transgenic mice, we propose to produce knock-in mice in which red fluorescent protein (RFP) and a truncated human CD4 are introduced into the alpha-gustducin locus such that they are faithfully expressed ..
  66. Novel Molecular Tools for Transsynaptic Circuit Analysis
    Haig Keshishian; Fiscal Year: 2007
    ..The carrier proteins will convey various cargos, such as GFP and RFP, across synapses in either a forward or reverse direction...