Gene Symbol: TRIM15
Description: tripartite motif containing 15
Alias: RNF93, ZNF178, ZNFB7, tripartite motif-containing protein 15, RING finger protein 93, zinc finger protein 178, zinc finger protein B7
Harada H, Harada Y, O Brien D, Rice D, Naeve C, Downing J. HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells. Mol Cell Biol. 1999;19:3808-15 pubmed
..These results suggest an important role for this protein in erythropoiesis. ..
Uchil P, Pawliczek T, Reynolds T, Ding S, Hinz A, Munro J, et al
. TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly. J Cell Sci. 2014;127:3928-42 pubmed publisher
..Here, we identify TRIM15, a member of the tripartite motif protein family, as a paxillin-interacting factor and a component of focal ..
Uchil P, Quinlan B, Chan W, Luna J, Mothes W. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. PLoS Pathog. 2008;4:e16 pubmed publisher
..In contrast, downregulation of TRIM11 and 15 enhanced virus release suggesting that these proteins contribute to the endogenous restriction of retroviruses in cells. ..
Mick E, McGough J, Deutsch C, Frazier J, Kennedy D, Goldberg R. Genome-wide association study of proneness to anger. PLoS ONE. 2014;9:e87257 pubmed publisher
..These results suggest that signaling pathways regulating intracellular calcium homeostasis, which are relevant to memory, learning, and neuronal survival, may in part underlie the expression of Angry Temperament. ..
Lee O, Lee J, Lee K, Woo Y, Kang J, Yoon H, et al
. Role of the focal adhesion protein TRIM15 in colon cancer development. Biochim Biophys Acta. 2015;1853:409-21 pubmed publisher
..Here, we show that TRIM15 co-localized to focal adhesions through homo-dimerization and significantly suppressed cell migration...
McElroy J, Cree B, Caillier S, Gregersen P, Herbert J, Khan O, et al
. Refining the association of MHC with multiple sclerosis in African Americans. Hum Mol Genet. 2010;19:3080-8 pubmed publisher
Goei V, Parimoo S, Capossela A, Chu T, Gruen J. Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection. Am J Hum Genet. 1994;54:244-51 pubmed
..A short fragment cDNA library derived from human duodenum was selected with the YAC DNA. Ten novel gene fragments were isolated, characterized, and localized on the physical map of the YAC. ..
Gruen J, Nalabolu S, Chu T, Bowlus C, Fan W, Goei V, et al
. A transcription map of the major histocompatibility complex (MHC) class I region. Genomics. 1996;36:70-85 pubmed
..We also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than has been appreciated. ..
Uchil P, Hinz A, Siegel S, Coenen Stass A, Pertel T, Luban J, et al
. TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. J Virol. 2013;87:257-72 pubmed publisher
..We also discovered a role for TRIM15 in the RIG-I-mediated interferon pathway upstream of MAVS...