TRIM11

Summary

Gene Symbol: TRIM11
Description: tripartite motif containing 11
Alias: BIA1, RNF92, E3 ubiquitin-protein ligase TRIM11, RING finger protein 92, RING-type E3 ubiquitin transferase TRIM11, tripartite motif-containing protein 11
Species: human
Products:     TRIM11

Top Publications

  1. Parodi S, Di Zanni E, Di Lascio S, Bocca P, Prigione I, Fornasari D, et al. The E3 ubiquitin ligase TRIM11 mediates the degradation of congenital central hypoventilation syndrome-associated polyalanine-expanded PHOX2B. J Mol Med (Berl). 2012;90:1025-35 pubmed publisher
    ..Finally, we show that the E3 ubiquitin ligase TRIM11 plays a critical role in the clearance of mutant PHOX2B through the proteasome...
  2. Ishikawa H, Tachikawa H, Miura Y, Takahashi N. TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system. FEBS Lett. 2006;580:4784-92 pubmed
    b>TRIM11 is a member of the tripartite-motif-containing protein family and is known to destabilize humanin, an inhibitor of Alzheimer-like neuronal insults...
  3. Uchil P, Quinlan B, Chan W, Luna J, Mothes W. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. PLoS Pathog. 2008;4:e16 pubmed publisher
    ..While TRIM11 and 31 inhibited HIV entry, TRIM11 enhanced N-MLV entry by interfering with Ref1 restriction...
  4. Niikura T, Hashimoto Y, Tajima H, Ishizaka M, Yamagishi Y, Kawasumi M, et al. A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults. Eur J Neurosci. 2003;17:1150-8 pubmed
    ..By means of yeast two-hybrid screening, we identified TRIM11 as a novel HN-interacting protein...
  5. Pan Y, Zhang R, Chen H, Chen W, Wu K, Lv J. Expression of Tripartite Motif-Containing Proteactiin 11 (TRIM11) is Associated with the Progression of Human Prostate Cancer and is Downregulated by MicroRNA-5193. Med Sci Monit. 2019;25:98-106 pubmed publisher
    BACKGROUND Tripartite motif-containing protein 11 (TRIM11), encoded by the TRIM11 gene, has been studied in some human malignant tumors...
  6. Roh H, Jeong C, Fujioka S, Kim Y, Lee S, Ahn J, et al. Genetic evidence for the reduction of brassinosteroid levels by a BAHD acyltransferase-like protein in Arabidopsis. Plant Physiol. 2012;159:696-709 pubmed publisher
    ..We isolated two gain-of-function mutants, brassinosteroid inactivator1-1Dominant (bia1-1D) and bia1-2D, in which a novel BAHD acyltransferase-like protein was transcriptionally activated...
  7. de Faria E, de Faria F, Gonçalves V, Franceschini S, Peluzio M, Sant Ana L, et al. Prediction of body fat in a dolescents: comparison of two electric bioimpedance devices with dual-energy X-ray absorptiometry. Nutr Hosp. 2014;30:1270-8 pubmed publisher
    ..The percentage of body fat (%BF) was estimated using 2 types of electrical bioimpedance devices: BIA1 (horizontal tetrapolar bioimpedance equipment) and BIA2 (vertical 8-electrode bioimpedance equipment), as well as ..
  8. Loux V, Mariadassou M, Almeida S, Chiapello H, Hammani A, Buratti J, et al. Mutations and genomic islands can explain the strain dependency of sugar utilization in 21 strains of Propionibacterium freudenreichii. BMC Genomics. 2015;16:296 pubmed publisher
    ..Scaffolds were ordered by comparison with the complete reference genome CIRM-BIA1, obtained previously using traditional Sanger sequencing...
  9. Bachtel N, Beckerle G, Mota T, Rougvie M, Raposo R, Jones R, et al. Expression of host restriction factors by memory CD4+ T cells differs between healthy donors and HIV-1 infected individuals with effective ART. AIDS Res Hum Retroviruses. 2018;: pubmed publisher
    ..In contrast CDKN1A, TRIM11 and BRD4, were expressed at lower levels in ART-suppressed compared to uninfected individuals...

More Information

Publications29

  1. Darshit B, Ramanathan M. Activation of AKT1/GSK-3β/β-Catenin-TRIM11/Survivin Pathway by Novel GSK-3β Inhibitor Promotes Neuron Cell Survival: Study in Differentiated SH-SY5Y Cells in OGD Model. Mol Neurobiol. 2016;53:6716-6729 pubmed
    ..protein 43 (GAP43), neurogenin1 (NGN1), neuronal differentiation 2 (NeuroD2), and tripartite motif containing 11 (TRIM11) genes were observed...
  2. Stittrich A, Ashworth J, Shi M, Robinson M, Mauldin D, Brunkow M, et al. Genomic architecture of inflammatory bowel disease in five families with multiple affected individuals. Hum Genome Var. 2016;3:15060 pubmed publisher
    ..analysis of our top novel variant in the remaining family, a rare missense mutation in the ubiquitin ligase TRIM11, suggests that it leads to increased nuclear factor of kappa light chain enhancer in B-cells (NF-?B) signaling...
  3. Chen L, Zhu G, Johns E, Yang X. TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14. Nat Commun. 2018;9:1223 pubmed publisher
    ..Here we report that TRIM11 enhances degradation of aberrant and normal regulatory proteins, and augments overall rate of proteolysis...
  4. Zhang Z, Xu L. Arabidopsis BRASSINOSTEROID INACTIVATOR2 is a typical BAHD acyltransferase involved in brassinosteroid homeostasis. J Exp Bot. 2018;69:1925-1941 pubmed publisher
    ..or dark treatment, but it exhibited a differential expression pattern compared with its homologue, BIA1. Furthermore, genetic transformation with point-mutant and deleted-BIA2 constructs confirmed that the HXXXD motif ..
  5. Cooper S, Hanson I. A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11. BMC Genet. 2005;6:43 pubmed
    ..the post-synaptic density (PSD) protein HOMER3, the dynein subunit DNCL1, and the tripartite motif protein TRIM11. Three C-terminal PAX6 mutations, previously identified in patients with eye malformations, all reduced or ..
  6. Yuan T, Yao W, Huang F, Sun B, Yang R. The human antiviral factor TRIM11 is under the regulation of HIV-1 Vpr. PLoS ONE. 2014;9:e104269 pubmed publisher
    b>TRIM11 has been reported to be able to restrict HIV-1 replication, but the detailed aspects of the interfering mechanisms remain unclear...
  7. Di K, Linskey M, Bota D. TRIM11 is overexpressed in high-grade gliomas and promotes proliferation, invasion, migration and glial tumor growth. Oncogene. 2013;32:5038-47 pubmed publisher
    b>TRIM11 (tripartite motif-containing protein 11), an E3 ubiquitin ligase, is known to be involved in the development of the central nervous system. However, very little is known regarding the role of TRIM11 in cancer biology...
  8. Aurino S, Piluso G, Saccone V, Cacciottolo M, D Amico F, Dionisi M, et al. Candidate-gene testing for orphan limb-girdle muscular dystrophies. Acta Myol. 2008;27:90-7 pubmed
    ..We identified a large number of variations in any of the genes in both patients and controls. Correlations with disease or possible modifying effects on the LGMD phenotype remain to be investigated. ..
  9. Wang X, Shi W, Shi H, Lu S, Wang K, Sun C, et al. TRIM11 overexpression promotes proliferation, migration and invasion of lung cancer cells. J Exp Clin Cancer Res. 2016;35:100 pubmed publisher
    Tripartite Motif Containing 11 (TRIM11), a member of TRIM proteins, is overexpressed in high-grade gliomas and plays an oncogenic function in glioma biology. However, little is known about the role of TRIM11 in lung cancer...
  10. Liu T, Tang Q, Liu K, Xie W, Liu X, Wang H, et al. TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy. Cell Rep. 2016;16:1988-2002 pubmed publisher
    ..Here, we report tripartite motif 11 (TRIM11) as a key negative regulator of the AIM2 inflammasome...
  11. Cellier L, Perron E, Pissaloux D, Karanian M, Haddad V, Alberti L, et al. Cutaneous Melanocytoma With CRTC1-TRIM11 Fusion: Report of 5 Cases Resembling Clear Cell Sarcoma. Am J Surg Pathol. 2018;42:382-391 pubmed publisher
    ..of primary intradermal nodular unpigmented tumors with a melanocytic immunophenotype associated with a novel CRTC1-TRIM11 fusion...
  12. Rodrigo Brenni M, Gutierrez E, Hegde R. Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6. Mol Cell. 2014;55:227-37 pubmed publisher
    ..Bag6-dependent ubiquitination can be recapitulated with purified components, paving the way for mechanistic analyses of downstream steps in this cytosolic quality control pathway...
  13. Liu J, Rao J, Lou X, Zhai J, Ni Z, Wang X. Upregulated TRIM11 Exerts its Oncogenic Effects in Hepatocellular Carcinoma Through Inhibition of P53. Cell Physiol Biochem. 2017;44:255-266 pubmed publisher
    ..However, little is known about the function and mechanism of TRIM11 in hepatocellular carcinoma (HCC)...
  14. Zhang Z, Xu C, Zhang X, Huang L, Zheng C, Chen H, et al. TRIM11 Upregulation Contributes to Proliferation, Invasion, and EMT of Hepatocellular Carcinoma Cells. Oncol Res. 2017;25:691-699 pubmed publisher
    The tripartite motif-containing protein 11 (TRIM11), a member of the TRIM protein family, has attracted much attention because of its involvement in the development of the central nervous system...
  15. Yuan T, Yao W, Tokunaga K, Yang R, Sun B. An HIV-1 capsid binding protein TRIM11 accelerates viral uncoating. Retrovirology. 2016;13:72 pubmed
    Several members of the TRIM family have been implicated in antiviral defense. Our previous report showed that human TRIM11 potently inhibited HIV-1 transduction by reducing the viral reverse transcripts...
  16. Singh A, Babyak M, Nolan D, Brummett B, Jiang R, Siegler I, et al. Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene. Eur J Hum Genet. 2015;23:854-62 pubmed publisher
  17. Lee Y, Song B, Park C, Kwon K. TRIM11 negatively regulates IFN? production and antiviral activity by targeting TBK1. PLoS ONE. 2013;8:e63255 pubmed publisher
    ..In this study, we identified TRIM11 (tripartite motif containing 11) as a novel negative regulator of IFN? production...
  18. Chen Y, Li L, Qian X, Ge Y, Xu G. High expression of TRIM11 correlates with poor prognosis in patients with hepatocellular carcinoma. Clin Res Hepatol Gastroenterol. 2017;41:190-196 pubmed publisher
    Tripartite Motif Containing 11 (TRIM11), a member of TRIM proteins is overexpressed in gliomas and lung cancer. However, the role of TRIM11 in hepatocellular carcinoma (HCC) is unknown...
  19. Hong S, Chae H, Lardaro T, Hong S, Kim K. Trim11 increases expression of dopamine beta-hydroxylase gene by interacting with Phox2b. Biochem Biophys Res Commun. 2008;368:650-5 pubmed publisher
    ..Using yeast two-hybrid screening, we isolated a Phox2b interacting protein, Trim11, which belongs to TRIM (Tripartite motif) or RBCC proteins family, and contains a RING domain, B-boxes, a coiled-..
  20. Yin Y, Zhong J, Li S, Li J, Zhou M, Chen Y, et al. TRIM11, a direct target of miR-24-3p, promotes cell proliferation and inhibits apoptosis in colon cancer. Oncotarget. 2016;7:86755-86765 pubmed publisher
    b>TRIM11 (tripartite motif-containing protein 11) is an E3 ubiquitin ligase recently identified as an oncogene in malignant glioma and lung cancer...