trichohyalin

Summary

Gene Symbol: trichohyalin
Description: trichohyalin
Alias: THH, THL, TRHY, UHS3, trichohyalin
Species: human
Products:     trichohyalin

Top Publications

  1. Wang P, Zhang J, Feng J, Wang S, Guo L, Wang Y, et al. Enhancement of acid re-assimilation and biosolvent production in Clostridium saccharoperbutylacetonicum through metabolic engineering for efficient biofuel production from lignocellulosic biomass. Bioresour Technol. 2019;281:217-225 pubmed publisher
    ..To further drive carbon flux for C4 metabolites and ultimate butanol production, key genes including hbd, thl, crt and bcd in butanol production pathway were further overexpressed...
  2. Tros R, Van Kessel M, van Kuijk S, Oosterhuis G, Kuchenbecker W, Kwee J, et al. The capacity of transvaginal hydrolaparoscopy versus hysterosalpingography to diagnose tubal pathology in the work-up of subfertile women, a randomised clinical trial. Eur J Obstet Gynecol Reprod Biol. 2019;236:127-132 pubmed publisher
    To assess the capacity of transvaginal hydrolaparoscopy (THL) versus hysterosalpingography (HSG) as a primary tool to diagnose tubal pathology...
  3. Yan P, Wen C, Zhang S, Zhang Z, Xu J, Deng M. A toxicological, metabonomic and transcriptional analysis to investigate the property of mulberry 1-deoxynojirimycin against the growth of Samia cynthia ricini. Pestic Biochem Physiol. 2018;152:45-54 pubmed publisher
    ..In addition, RT-qPCR results displayed that four genes coding α-glucosidase, trehalase (THL) and lactate dehydrogenase (LDH) were lowered in expression of 12 h DNJ groups...
  4. Gregg L, Jung K, Spradley J, Nyilas R, Suplita R, Zimmer A, et al. Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-? initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. J Neurosci. 2012;32:9457-68 pubmed publisher
    ..activity in the dlPAG with RHC80267 [1,6-bis(cyclohexyloximinocarbonylamino)hexane] and (-)-tetrahydrolipstatin (THL), which inhibit activity of DGL-? and DGL-? isoforms, suppressed stress-induced antinociception...
  5. Chandra P, Gerlach S, Wu C, Khurana N, Swientoniewski L, Abdel Mageed A, et al. Mesenchymal stem cells are attracted to latent HIV-1-infected cells and enable virus reactivation via a non-canonical PI3K-NFκB signaling pathway. Sci Rep. 2018;8:14702 pubmed publisher
    ..conditioned media (MSC-CM) rapidly increased HIV-1 p24 production from the latently-infected U1 (MAC) & ACH2 (THL) cell lines...
  6. Yu Q, Saruta M, Avanesyan A, Fleshner P, Banham A, Papadakis K. Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis. Inflamm Bowel Dis. 2007;13:191-9 pubmed
    ..In addition, CD4+CD25+ T cells potently suppress the production of both Thl (IFN-gamma, IL-2) and Th2 (IL-5, IL-13) cytokines by cocultured CD4+CD25 T cells...
  7. Touchette M, Holsclaw C, Previti M, Solomon V, Leary J, Bertozzi C, et al. The rv1184c locus encodes Chp2, an acyltransferase in Mycobacterium tuberculosis polyacyltrehalose lipid biosynthesis. J Bacteriol. 2015;197:201-10 pubmed publisher
    ..presence of the predicted catalytic residue Ser141 and was inhibited by the lipase inhibitor tetrahydrolipstatin (THL). THL treatment of M...
  8. Shonesy B, Winder D, Patel S, Colbran R. The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium. Neuropharmacology. 2015;91:57-62 pubmed publisher
    ..50 mV were blocked by chelation of postsynaptic Ca(2+) using BAPTA or by bath application of tetrahydrolipstatin (THL), a DGL inhibitor...
  9. Lamarche D, Notley S, Poirier M, Kenny G. Self-reported physical activity level does not alter whole-body total heat loss independently of aerobic fitness in young adults during exercise in the heat. Appl Physiol Nutr Metab. 2018;: pubmed publisher
    We evaluated whether self-reported physical activity (PA) level modulates whole-body total heat loss (WB-THL) as assessed using direct calorimetry in ten young adults (22±3 years) matched for rate of peak oxygen consumption (V?O2peak; ..

More Information

Publications77

  1. Liu H, Tian N, Ye J, Lu B, Ren J, Huangfu Z, et al. A comparative study of CO adsorption on tetrahexahedral Pt nanocrystals and interrelated Pt single crystal electrodes by using cyclic voltammetry and in situ FTIR spectroscopy. Faraday Discuss. 2014;176:409-28 pubmed publisher
    This study focuses on CO adsorption at tetrahexahedral Pt nanocrystals (THH Pt NCs) by using cyclic voltammetry and in situ FTIR spectroscopy...
  2. Cinar M, Rosenfelt F, Rokhsar S, Lopategui J, Pillai R, Cervania M, et al. Concurrent inhibition of MYC and BCL2 is a potentially effective treatment strategy for double hit and triple hit B-cell lymphomas. Leuk Res. 2015;39:730-8 pubmed publisher
    Double hit lymphoma or triple hit lymphoma (DHL/THL) is a rare form of aggressive B-Cell Lymphoma. Overexpression of MYC, BCL2 or/and BCL6 due to genomic rearrangements are the key molecular features of DHL/THL...
  3. Guo Y, Wang Y, Shi X, Qin W, Zhang X, Xu J, et al. A metabolomics study on the immunosuppressive effect of Tripterygium hypoglaucum (Levl.) Hutch in mice: The discovery of pathway differences in serum metabolites. Clin Chim Acta. 2018;483:94-103 pubmed publisher
    Tripterygium hypoglaucum (Levl.) Hutch (THH), a typical traditional Chinese medicine, is widely used in clinical practice for the treatment of rheumatoid arthritis, systemic lupus erythematous, and other connective tissue and autoimmune ..
  4. Ma C, Kojima K, Xu N, Mobley J, Zhou L, Yang S, et al. Comparative proteomics analysis of high n-butanol producing metabolically engineered Clostridium tyrobutyricum. J Biotechnol. 2015;193:108-19 pubmed publisher
    ..68 g/L of butanol. In ACKKO-adhE2, the expression of most glycolytic enzymes was decreased, the thiolase (thl), acetyl-CoA acetyltransferase (ato), 3-hydroxybutyryl-CoA dehydrogenase (hbd) and crotonase (crt) that convert ..
  5. Berlit S, Tuschy B, Wuhrer A, Jürgens S, Buchweitz O, Kircher A, et al. Sexual functioning after total versus subtotal laparoscopic hysterectomy. Arch Gynecol Obstet. 2018;: pubmed publisher
    ..differences only 3 months after surgery, as improvement was stronger for the LASH collective compared to the THL group (p?=?0.006). There were no changes comparing collectives after 6 (p?=?0.663) and 12 (p?=?0.326) months...
  6. Anttila J, Rytkönen T, Kankaanpää R, Tolvanen M, Lahti S. Effect of national recommendation on sweet selling as an intervention for a healthier school environment. Scand J Public Health. 2015;43:27-34 pubmed publisher
    In 2007, the Finnish National Board of Education (FNBE) and the National Institute for Health and Welfare (THL) gave a national recommendation that Finnish upper comprehensive schools should not sell sweet products...
  7. Ellidag H, Aydin O, Eren E, Yilmaz N, Ergin M. Decreased HDL-dependent paraoxonase and arylesterase enzyme activity may indicate a worse prognosis in multiple myeloma. Asian Pac J Cancer Prev. 2014;15:9847-51 pubmed
    ..Total thiol (T.thl), oxidative stress index (OSI), total oxidant status (TOS) and total antioxidant status (TAS) were examined in ..
  8. Chen C, Lin Y, Wu S, Mi F. Mutlifunctional nanoparticles prepared from arginine-modified chitosan and thiolated fucoidan for oral delivery of hydrophobic and hydrophilic drugs. Carbohydr Polym. 2018;193:163-172 pubmed publisher
    Self-assembled nanoparticles (NPs) from arginine-modified chitosan (CS-N-Arg) and thiolated fucoidan (THL-fucoidan) were synthesized to enhance the transport of dextran and curcumin across intestinal epithelial cell layer...
  9. Tan C, Gery I. The unique features of Th9 cells and their products. Crit Rev Immunol. 2012;32:1-10 pubmed
    ..Interestingly, no IL-9-producing cells were detected in sites of inflammation induced by Th9, in contrast to Thl and Thl7...
  10. Péterfi Z, Urbán G, Papp O, Németh B, Monyer H, Szabó G, et al. Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons. J Neurosci. 2012;32:14448-63 pubmed publisher
    ..was evoked in the presence of the mGlu(5) antagonist MPEP [2-methyl-6-(phenylethynyl)-pyridine], the DGL inhibitor THL [N-formyl-l-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester], or the intracellularly applied ..
  11. Sato K, Okajima F, Miyashita K, Imamura S, Kobayashi J, Stanhope K, et al. The majority of lipoprotein lipase in plasma is bound to remnant lipoproteins: A new definition of remnant lipoproteins. Clin Chim Acta. 2016;461:114-25 pubmed publisher
    ..Tetrahydrolipstatin (THL), a potent inhibitor of serine lipases, was used to block the lipolytic activity of LPL, thereby preventing changes ..
  12. Wang L, Ye Y, Zhang Y, Xiao T. Curative effect of BCG-polysaccharide nuceic acid on atopic dermatitis in mice. Asian Pac J Trop Med. 2014;7:913-7 pubmed publisher
    ..significantly reduce the serum IgE concentrations, increase the expression of IL-12, IFN-γ protein, correct the imbalance of Thl/Th2 in atopic dermatitis mice, and has obvious inhibitory effect on atopic dermatitis in NC/Nga mice.
  13. Gannasin S, Adzahan N, Mustafa S, Muhammad K. Techno-functional properties and in vitro bile acid-binding capacities of tamarillo (Solanum betaceum Cav.) hydrocolloids. Food Chem. 2016;196:903-9 pubmed publisher
    ..32-36%), whereas the pulp hydrocolloids that were extracted, using 72% ethanol (THE) or 20mM HEPES buffer (THH), had no foaming capacity...
  14. Kwon Y, Bose S, Steele R, Meyer K, Di Bisceglie A, Ray R, et al. Promotion of Cancer Stem-Like Cell Properties in Hepatitis C Virus-Infected Hepatocytes. J Virol. 2015;89:11549-56 pubmed publisher
    ..We also found c-Kit is highly expressed in transformed human hepatocytes (THH) infected in vitro with cell culture-grown HCV genotype 2a...
  15. Sozutek A, Ozyazici S, Colak T, Cetinkünar S, Irkorucu O, Bobusoglu O, et al. Evaluating the effect of infliximab on the healing of left colonic anastomosis in the presence of intra-abdominal sepsis. Arab J Gastroenterol. 2016;17:84-9 pubmed publisher
    ..efficiency of IFX was assessed with respect to anastomotic bursting pressure (ABP), tissue hydroxyproline levels (THL) and histopathological examination of left colonic anastomosis in 40 male rats...
  16. Arenas Ruiz J, Martinez Maldonado H, González Carranza V, Torres García S, Chico Ponce de León F. Endoscopic ventriculo-cisterno-ventricular approach in the treatment of bilateral trapped temporal horn related to fungal infection in a child: case report and review of the literature. Childs Nerv Syst. 2018;34:1593-1597 pubmed publisher
    ..Even though this is a rare condition, we believe it is a safe and effective option to eliminate multiple shunts and/or to reduce the number of catheters needed to treat bilateral THH related to multi-septated hydrocephalus.
  17. Palmu A, Jokinen J, Nieminen H, Rinta Kokko H, Ruokokoski E, Puumalainen T, et al. Vaccine-preventable disease incidence of pneumococcal conjugate vaccine in the Finnish invasive pneumococcal disease vaccine trial. Vaccine. 2018;36:1816-1822 pubmed publisher
    ..Outcome data were collected using Finnish routine health-care registers, consisting of THL National Infectious Diseases Register, THL Care register, and Benefits Register of Social Insurance Institution of ..
  18. van Kessel M, Tros R, Oosterhuis J, Kuchenbecker W, Vernooij E, Bongers M, et al. The prognostic capacity of transvaginal hydrolaparoscopy to predict non-IVF conception. Reprod Biomed Online. 2018;36:552-559 pubmed publisher
    Transvaginal hydrolaparoscopy (THL) is performed to investigate tubal pathology in subfertile women. This retrospective multicentre cohort study investigated the results of THL and subsequent pregnancy rates...
  19. Yao C, Chow J, Yang C, Kuo H, Chang C, Lee H, et al. Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation. Evid Based Complement Alternat Med. 2016;2016:3251046 pubmed publisher
    The Chinese herbal mixture, Tien-Hsien Liquid (THL), has been proven to suppress the growth and invasiveness of cancer cells and is currently regarded as a complementary medicine for the treatment of cancer...
  20. Nishiguchi Y, Ohmoto M, Koki J, Enomoto T, Kominami R, Matsumoto I, et al. Bcl11b/Ctip2 is required for development of lingual papillae in mice. Dev Biol. 2016;416:98-110 pubmed publisher
    ..These results indicate that Bcl11b regulates the differentiation of keratinocytes in the tongue and identify Bcl11b as an essential factor for the lingual papilla morphogenesis. ..
  21. Rej S, Hsia C, Chen T, Lin F, Huang J, Huang M. Facet-Dependent and Light-Assisted Efficient Hydrogen Evolution from Ammonia Borane Using Gold-Palladium Core-Shell Nanocatalysts. Angew Chem Int Ed Engl. 2016;55:7222-6 pubmed publisher
    Au-Pd core-shell nanocrystals with tetrahexahedral (THH), cubic, and octahedral shapes and comparable sizes were synthesized. Similar-sized Au and Pd cubes and octahedra were also prepared...
  22. Sánchez Fuentes A, Marichal Cancino B, Méndez Díaz M, Becerril Meléndez A, Ruiz Contreras A, Prospero Garcia O. mGluR1/5 activation in the lateral hypothalamus increases food intake via the endocannabinoid system. Neurosci Lett. 2016;631:104-8 pubmed publisher
    ..mGluR1/5 agonist); (iii) 2-AG (CB1 endogenous agonist); (iv) AM251 (CB1 antagonist); (v) tetrahydrolipstatin (THL, 1.2?g; diacyl-glycerol lipase inhibitor); and (vi) combinations of CHPG?+?with the other aforementioned drugs...
  23. Rens C, Laval F, Daffé M, Denis O, Frita R, Baulard A, et al. Effects of Lipid-Lowering Drugs on Vancomycin Susceptibility of Mycobacteria. Antimicrob Agents Chemother. 2016;60:6193-9 pubmed publisher
    ..and in Mycobacterium tuberculosis We tested three drugs already used to treat human obesity: tetrahydrolipstatin (THL), simvastatin, and fenofibrate. Only vancomycin and THL were able to synergize on M. bovis BCG and on M...
  24. Zhao Z, Jiang Y, Li Q, Cai Y, Yin H, Zhang L, et al. Spatial correlation analysis of polycyclic aromatic hydrocarbons (PAHs) and organochlorine pesticides (OCPs) in sediments between Taihu Lake and its tributary rivers. Ecotoxicol Environ Saf. 2017;142:117-128 pubmed publisher
    ..PAHs) and organochlorine pesticides (OCPs) in surface sediments from Taihu Lake basin (THB) and Taihu Lake body (THL) were investigated. Higher concentrations of both PAHs and OCPs were observed for THB than THL...
  25. Landsburg D, Petrich A, Abramson J, Sohani A, Press O, Cassaday R, et al. Impact of oncogene rearrangement patterns on outcomes in patients with double-hit non-Hodgkin lymphoma. Cancer. 2016;122:559-64 pubmed publisher
    ..MYC+/BCL2+/BCL6- (BCL2-DHL), MYC+/BCL2-/BCL6+ (BCL6-DHL), and MYC+/BCL2+/BCL6+ (triple-hit lymphoma; THL)...
  26. Carey L, Berry D, Cirrincione C, Barry W, Pitcher B, Harris L, et al. Molecular Heterogeneity and Response to Neoadjuvant Human Epidermal Growth Factor Receptor 2 Targeting in CALGB 40601, a Randomized Phase III Trial of Paclitaxel Plus Trastuzumab With or Without Lapatinib. J Clin Oncol. 2016;34:542-9 pubmed publisher
    ..biopsy followed by random assignment to paclitaxel plus trastuzumab alone (TH) or with the addition of lapatinib (THL) for 16 weeks before surgery. An investigational arm of paclitaxel plus lapatinib (TL) was closed early...
  27. Pelkonen S, Gissler M, Koivurova S, Lehtinen S, Martikainen H, Hartikainen A, et al. Physical health of singleton children born after frozen embryo transfer using slow freezing: a 3-year follow-up study. Hum Reprod. 2015;30:2411-8 pubmed publisher
    ..The National Institute for Health and Welfare (THL) covered the data linkages and the work of Mika Gissler. There are no competing interests to be reported.
  28. Loder A, Zeldes B, Garrison G, Lipscomb G, Adams M, Kelly R. Alcohol Selectivity in a Synthetic Thermophilic n-Butanol Pathway Is Driven by Biocatalytic and Thermostability Characteristics of Constituent Enzymes. Appl Environ Microbiol. 2015;81:7187-200 pubmed publisher
    ..Recombinant versions of eight thermophilic enzymes (β-ketothiolase [Thl], 3-hydroxybutyryl-CoA dehydrogenase [Hbd], and 3-hydroxybutyryl-CoA dehydratase [Crt] from Caldanaerobacter ..
  29. Rastogi R, Kumar A, Kaur J, Saini V, Kaur J, Bhatnagar A. Rv0646c, an esterase from M. tuberculosis, up-regulates the host immune response in THP-1 macrophages cells. Mol Cell Biochem. 2018;447:189-202 pubmed publisher
    ..The esterase activity was abolished in the presence of serine hydrolase inhibitors, THL and PMSF. Various antigenic epitopes were predicted in Rv0646c...
  30. Biernacki M, Riechen J, Hähnel U, Roick T, Baronian K, Bode R, et al. Production of (R)-3-hydroxybutyric acid by Arxula adeninivorans. AMB Express. 2017;7:4 pubmed publisher
    ..Overexpression of thl and phaB genes in organisms cultured in a shaking flask resulted in 4...
  31. Lee S, Kim S, Kim J, Cheong N, Kim K. Enhanced butanol fermentation using metabolically engineered Clostridium acetobutylicum with ex situ recovery of butanol. Bioresour Technol. 2016;218:909-17 pubmed publisher
    ..Based on this quantitative analysis, the BEKW_E1AB-atoB strain was constructed by overexpressing the thl (atoB), adhE1, and ctfAB genes in Clostridium acetobutylicum strain BEKW, which has the phosphotransacetylase (pta) ..
  32. Linden J, Josefsson K, Widström E. Frequency of visits and examinations in the Public Dental Service in Finland - a retrospective analysis, 2001-2013. BMC Oral Health. 2017;17:138 pubmed publisher
    ..Ethical approval was given by the National Institute for Health and Welfare (THL) and permissions to use local data by the directors of health services in each unit...
  33. Qin Y, Pan W, Yu D, Lu Y, Wu W, Zhou J. Stepwise evolution of Au micro/nanocrystals from an octahedron into a truncated ditetragonal prism. Chem Commun (Camb). 2018;54:3411-3414 pubmed publisher
    Shape transformation of Au crystals from a {111}-bounded octahedron to a {730}-bounded tetrahexahedron (THH) and then to a {310}-bounded truncated ditetragonal prism (TDP) was achieved by a one pot synthesis method...
  34. Mattinen M, Valle Delgado J, Leskinen T, Anttila T, Rivière G, Sipponen M, et al. Enzymatically and chemically oxidized lignin nanoparticles for biomaterial applications. Enzyme Microb Technol. 2018;111:48-56 pubmed publisher
    ..e. spherical shape and size. Two fungal laccases, Trametes hirsuta (ThL) and Melanocarpus albomyces (MaL) were used in the cross-linking reactions...
  35. Guo X, Guo R, Luo X, Zhou L. Ethyl pyruvate ameliorates experimental colitis in mice by inhibiting the HMGB1-Th17 and Th1/Tc1 responses. Int Immunopharmacol. 2015;29:454-461 pubmed publisher
    ..HMGB1 has been implicated in several autoimmune diseases by inducing Thl and Thl7 cells activation...
  36. Goins C, Dajnowicz S, Smith M, Parks J, Ronning D. Mycolyltransferase from Mycobacterium tuberculosis in covalent complex with tetrahydrolipstatin provides insights into antigen 85 catalysis. J Biol Chem. 2018;293:3651-3662 pubmed publisher
    ..45-Å X-ray crystal structure of M. tuberculosis Ag85C covalently modified by tetrahydrolipstatin (THL), an esterase inhibitor that suppresses M. tuberculosis growth and mimics structural attributes of MAs...
  37. Giampaolino P, Morra I, Tommaselli G, Di Carlo C, Nappi C, Bifulco G. Post-operative ovarian adhesion formation after ovarian drilling: a randomized study comparing conventional laparoscopy and transvaginal hydrolaparoscopy. Arch Gynecol Obstet. 2016;294:791-6 pubmed publisher
    To compare conventional laparoscopic ovarian drilling (LOD) with transvaginal hydrolaparoscopy (THL) ovarian drilling in terms of ovarian adhesion formation, evaluated using office THL during follow-up in CC-resistant anovulatory ..
  38. Silva J, Carmo H, Carvalho F. The synthetic cannabinoid XLR-11 induces in vitro nephrotoxicity by impairment of endocannabinoid-mediated regulation of mitochondrial function homeostasis and triggering of apoptosis. Toxicol Lett. 2018;287:59-69 pubmed publisher
    ..Our findings using specific inhibitors of endogenous cannabinoids biosynthesis (i.e. MAFP and THL) further evidenced the involvement of the endocannabinoid system in the regulation of these processes, as XLR-11 ..
  39. Giampaolino P, Pellicano M, Tommaselli G, Bifulco G, Simioli S, Nappi C, et al. In-office transvaginal hydrolaparoscopy: a step-by-step, intraoperative pain evaluation. Arch Gynecol Obstet. 2015;292:1373-7 pubmed publisher
    Transvaginal hydrolaparoscopy (THL) is a mini-invasive technique, which allows exploration of the posterior pelvis...
  40. Wang H, Lu C, Zhao J, Gao L, Li X, Hou J, et al. Feasibility of prophylactic laparoscopic appendectomy in obese patients. Clin Exp Obstet Gynecol. 2016;43:238-40 pubmed
    ..undergoing total laparoscopic hysterectomy (TLH) along (66 patients, TLH group) or in combination (55 patients, THL+LA group) with laparoscopic appendectomy (LA) between 2007 and 2012...
  41. Kayyali R, Hesso I, Ejiko E, Nabhani Gebara S. A qualitative study of Telehealth patient information leaflets (TILs): are we giving patients enough information?. BMC Health Serv Res. 2017;17:362 pubmed publisher
    ..the use of discourse analysis to compare 12 electronically and publically available THLs, with the existing THL guidance "Involve Yorkshire and Humber"...
  42. Sinai L, Ivakine E, Lam E, Deurloo M, Dida J, Zirngibl R, et al. Disruption of Src Is Associated with Phenotypes Related to Williams-Beuren Syndrome and Altered Cellular Localization of TFII-I(1,2). Eneuro. 2015;2: pubmed publisher
    ..Mice homozygous for a spontaneous mutation in Src (Src (thl/thl) ) exhibited hypersociability and hyperactivity along with impairments in visuospatial, amygdala-dependent, and ..
  43. Coenders Tros R, Van Kessel M, Vernooij M, Oosterhuis G, Kuchenbecker W, Mol B, et al. Performance of outpatient transvaginal hydrolaparoscopy. Hum Reprod. 2016;31:2285-91 pubmed publisher
    What is the feasibility of performing transvaginal hydrolaparoscopy (THL) in an outpatient setting? It is feasible to perform THL in an outpatient setting, reflected by a low complication and failure rate and a high patients' ..
  44. Ravindran M, Wenk M. Activity-Based Lipid Esterase Profiling of M. bovis BCG at Different Metabolic States Using Tetrahydrolipstatin (THL) as Bait. Methods Mol Biol. 2017;1491:75-85 pubmed
    ..Here, we investigate the molecular mechanism behind the bactericidal activity of tetrahydrolipstatin (THL). ABPP relies on small molecule probes that target the active site of specific enzymes in complex proteomes...
  45. Steinert P, Parry D, Marekov L. Trichohyalin mechanically strengthens the hair follicle: multiple cross-bridging roles in the inner root shealth. J Biol Chem. 2003;278:41409-19 pubmed
    b>Trichohyalin is expressed in specialized epithelia that are unusually mechanically strong, such as the inner root sheath cells of the hair follicle...
  46. Zhou X, Xu P, Chen H, Zhao Y, Shen J, Jiang C, et al. Thalidomide Inhibits TGF-?1-induced Epithelial to Mesenchymal Transition in Alveolar Epithelial Cells via Smad-Dependent and Smad-Independent Signaling Pathways. Sci Rep. 2017;7:14727 pubmed publisher
    ..In vivo models have suggested that thalidomide (THL) has anti-fibrotic effects against pulmonary fibrosis, but the underlying mechanism of this effect is not clear...
  47. Wu S, Tan J, Yang Y, Peng Q, Zhang M, Li J, et al. Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations. Hum Genet. 2016;135:1279-1286 pubmed
    ..A recent genome-wide scan found common variants in the Trichohyalin (TCHH) gene that are associated with hair straightness in Europeans, but different genes might affect this ..
  48. Petrova A, Capalbo A, Jacquet L, Hazelwood Smith S, Dafou D, Hobbs C, et al. Induced Pluripotent Stem Cell Differentiation and Three-Dimensional Tissue Formation Attenuate Clonal Epigenetic Differences in Trichohyalin. Stem Cells Dev. 2016;25:1366-75 pubmed publisher
    ..complex, a region on chromosome 1 that contains multiple genes involved in skin barrier maturation (including trichohyalin, TCHH), found that in one of the iPSC clones (iKCL004), TCHH retained a DNA methylation signature ..
  49. Liu F, Chen Y, Zhu G, Hysi P, Wu S, Adhikari K, et al. Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair. Hum Mol Genet. 2017;: pubmed publisher
    ..Our study thus delivers target genes and DNA variants for future functional studies to further evaluate the molecular basis of hair shape in humans...
  50. Dong W, Ren Y, Bai Z, Jiao J, Chen Y, Han B, et al. Synthesis of tetrahexahedral Au-Pd core-shell nanocrystals and reduction of graphene oxide for the electrochemical detection of epinephrine. J Colloid Interface Sci. 2018;512:812-818 pubmed publisher
    An innovative epinephrine sensor was fabricated by integrating tetrahexahedral (THH) Au-Pd core-shell nanocrystals on reduced graphene oxide (rGO) nanosheets...
  51. Shane D, Larson R, Sanderson M, Miesner M, White B. A deterministic, dynamic systems model of cow-calf production: The effects of breeding replacement heifers before mature cows over a 10-year horizon. J Anim Sci. 2017;95:4533-4532 pubmed publisher
    ..cows) before cows (primiparous and multiparous cows), sometimes referred to as providing a heifer lead time (tHL)...
  52. Wang L, Wang L, Zhang J, Zhang P, Li S. [Th1/Th2 and Treg/Th17 cell balance in peripheral blood of patients with ovarian cancer]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:1066-1070 pubmed
    To investigate the changes in the percentages and balance of CD4+T cell subsets including T helper cells (Thl, Th2, and Thl7) and T regulatory cells (Treg) in patients with ovarian cancer...
  53. Singh P, Markwick R, Lu L, Howell F, Williams G, Doherty P. Assay and Inhibition of the Purified Catalytic Domain of Diacylglycerol Lipase Beta. Biochemistry. 2016;55:2713-21 pubmed publisher
    ..Activity of the enzyme was confirmed using EnzChek as well as two DAGL inhibitors (THL and OMDM-188)...
  54. Hardy E, Wyss K, Gorden J, Ariyarathna I, Miliordos E, Gorden A. Th(iv) and Ce(iv) napthylsalophen sandwich complexes: characterization of unusual thorium fluorescence in solution and solid-state. Chem Commun (Camb). 2017;53:11984-11987 pubmed publisher
    ..The ThL2 complex, unlike the isovalent CeL2, complex possesses unusual fluorescence properties in ..
  55. Fietz M, Rogers G, Eyre H, Baker E, Callen D, Sutherland G. Mapping of the trichohyalin gene: co-localization with the profilaggrin, involucrin, and loricrin genes. J Invest Dermatol. 1992;99:542-4 pubmed
    The chromosomal location of the gene encoding the human hair follicle protein trichohyalin has been determined by in situ hybridization. The human gene has been localized to the region 1q21.1-1q23 (probably 1q21...
  56. Yamamoto S, Hirai K, Hasegawa Oka Y, Hirai Y. Molecular elements of the regulatory control of keratin filament modulator AHF/trichohyalin in the hair follicle. Exp Dermatol. 2009;18:152-9 pubmed publisher
    ..expression of the IRS-specific protein AHF (Anagenic Hair Follicle antigen), the putative mouse orthologue of trichohyalin (THH), which plays a key role in the assembly of keratin intermediate filaments (IFs) during the hair cycle...
  57. Steinmetz A, Freeman J. Cannabinoid modulation of memory consolidation within the cerebellum. Neurobiol Learn Mem. 2016;136:228-235 pubmed publisher
    ..session, during memory consolidation, the cannabinoid inverse agonist SR141716A or the endocannabinoid suppressor THL impaired memory...
  58. Leung M, Sutton C, Fenton D, Tobin D. Trichohyalin is a potential major autoantigen in human alopecia areata. J Proteome Res. 2010;9:5153-63 pubmed publisher
    ..mass spectrometry, which indicated strong reactivity to the hair growth phase-specific structural protein trichohyalin in all AA sera. Keratin 16 (K16) was also identified as another potential AA-relevant target HF antigen...
  59. Li Y, Zhou G, Zhang R, Guo J, Li C, Martin G, et al. Comparative proteomic analyses using iTRAQ-labeling provides insights into fiber diversity in sheep and goats. J Proteomics. 2018;172:82-88 pubmed publisher
    ..RNA-seq further validated the DSC2 gene is key to the woolly/straight hair phenotype in goats. ..
  60. Wang S, Dong S, Wang Y. Enhancement of solvent production by overexpressing key genes of the acetone-butanol-ethanol fermentation pathway in Clostridium saccharoperbutylacetonicum N1-4. Bioresour Technol. 2017;245:426-433 pubmed publisher
    ..genes (either endogenous or exogenous) including the sol operon (bld-ctfA-ctfB-adc), adhE1, adhE1D485G, thl, thlA1V5A, thlAV5A and the expression cassette EC (thl-hbd-crt-bcd) were overexpressed in C...
  61. Kaur G, Sharma A, Narang T, Dogra S, Kaur J. Characterization of ML0314c of Mycobacterium leprae and deciphering its role in the immune response in leprosy patients. Gene. 2018;643:26-34 pubmed publisher
    ..E-serine, DEPC and Tetrahydrolipstatin (THL) completely inhibited the activity of ML0314c. The protein was localized in cell wall and extracellular medium...
  62. O Keefe E, Hamilton E, Lee S, Steinert P. Trichohyalin: a structural protein of hair, tongue, nail, and epidermis. J Invest Dermatol. 1993;101:65S-71S pubmed
    In the course of studies of desmosomes, we found trichohyalin, a 200-kDa protein of the inner root sheath and medulla, in a citric acid-insoluble fraction ("desmosome preparation") from tongue epithelium...
  63. Lee S, Wang M, McBride O, O Keefe E, Kim I, Steinert P. Human trichohyalin gene is clustered with the genes for other epidermal structural proteins and calcium-binding proteins at chromosomal locus 1q21. J Invest Dermatol. 1993;100:65-8 pubmed
    b>Trichohyalin is a major differentiation product of hard keratinizing tissues such as the inner root sheath and medullary cells of the hair follicle and the filiform papillae of the tongue, as well as terminally differentiating epidermal ..
  64. Ü Basmanav F, Cau L, Tafazzoli A, Méchin M, Wolf S, Romano M, et al. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome. Am J Hum Genet. 2016;99:1292-1304 pubmed publisher
    ..mutations located in the three genes PADI3 (peptidylarginine deiminase 3), TGM3 (transglutaminase 3), and TCHH (trichohyalin) in a total of 11 children...
  65. Medland S, Nyholt D, Painter J, McEvoy B, McRae A, Zhu G, et al. Common variants in the trichohyalin gene are associated with straight hair in Europeans. Am J Hum Genet. 2009;85:750-5 pubmed publisher
    ..All three samples showed evidence of association implicating the Trichohyalin gene (TCHH), which is expressed in the developing inner root sheath of the hair follicle, and explaining ..
  66. Pośpiech E, Karłowska Pik J, Marcińska M, Abidi S, Andersen J, Berge M, et al. Evaluation of the predictive capacity of DNA variants associated with straight hair in Europeans. Forensic Sci Int Genet. 2015;19:280-288 pubmed publisher
    ..The only genome-wide association study made to date revealed the Trichohyalin gene (TCHH) to be significantly associated with hair morphology in Europeans and reported weaker associations ..
  67. Ji X, Huang J, Hui M, Zhang Y, Zhao Y. Proteonmic Analysis And Immunoregulation Mechanism Of Wheat Germ Globulin. Protein Pept Lett. 2017;: pubmed publisher
    ..The underlying mechanisms might be related to the variational proportion of Thl/Th2 cells resulted from the control of the mRNA expression levels of T-Bet and GATA-3.
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    b>Trichohyalin is an intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis and is a ..