Gene Symbol: TRIB1
Description: tribbles pseudokinase 1
Alias: C8FW, GIG-2, GIG2, SKIP1, TRB-1, TRB1, tribbles homolog 1, G-protein-coupled receptor induced protein, G-protein-coupled receptor-induced gene 2 protein, G-protein-coupled receptor-induced protein 2, phosphoprotein regulated by mitogenic pathways, tribbles-like protein 1
Species: human
Products:     TRIB1

Top Publications

  1. Kiss Toth E, Bagstaff S, Sung H, Jozsa V, Dempsey C, Caunt J, et al. Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. J Biol Chem. 2004;279:42703-8 pubmed
    ..These results suggest that Trbs control both the extent and the specificity of MAPK kinase activation of MAPK. ..
  2. Wilkin F, Suarez Huerta N, Robaye B, Peetermans J, Libert F, Dumont J, et al. Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells. Eur J Biochem. 1997;248:660-8 pubmed
    ..Immunofluorescence and subcellular fractionation analysis have revealed that c-myc-tagged clone c5fw was insoluble and localized mainly in the cytoplasm, in the form of granules. ..
  3. Wu M, Xu L, Zhai Z, Shu H. SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription. J Biol Chem. 2003;278:27072-9 pubmed
    ..Taken together, these data suggest that SINK is critically involved in a novel negative feedback control pathway of NF-kappaB-induced gene expression. ..
  4. Tai E, Sim X, Ong T, Wong T, Saw S, Aung T, et al. Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population. J Lipid Res. 2009;50:514-20 pubmed publisher
    ..A polymorphism adjacent to the TRIB1 locus (rs17321515) was associated with elevated total cholesterol and LDL-cholesterol (LDL-C) after adjustment for ..
  5. Nakayama K, Bayasgalan T, Yamanaka K, Kumada M, Gotoh T, Utsumi N, et al. Large scale replication analysis of loci associated with lipid concentrations in a Japanese population. J Med Genet. 2009;46:370-4 pubmed publisher
    ..1x10(-11), 4.7 mg/dl decrease per minor G allele) in the Japanese population. SNPs near ANGPTL3, TRIB1 and GALNT2 showed evidence for associations with triglyceride concentrations (3.6x10(-6)<p<5.1x10(-5))...
  6. Angyal A, Kiss Toth E. The tribbles gene family and lipoprotein metabolism. Curr Opin Lipidol. 2012;23:122-6 pubmed publisher
  7. Sung H, Guan H, Czibula A, King A, Eder K, Heath E, et al. Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways. J Biol Chem. 2007;282:18379-87 pubmed
    ..In summary, the data presented here suggest an important regulatory role for trb-1 in vascular smooth muscle cell biology. ..
  8. Wang J, Ban M, Zou G, Cao H, Lin T, Kennedy B, et al. Polygenic determinants of severe hypertriglyceridemia. Hum Mol Genet. 2008;17:2894-9 pubmed publisher
    ..We determined genotypes for: GALNT2 rs4846914, TBL2/MLXIPL rs17145738, TRIB1 rs17321515, ANGPTL3 rs12130333, GCKR rs780094, APOA5 rs3135506 (S19W), APOA5 rs662799 (-1131T > C), APOE (..
  9. Hegele R, Ban M, Hsueh N, Kennedy B, Cao H, Zou G, et al. A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia. Hum Mol Genet. 2009;18:4189-94 pubmed publisher
    ..We found that several SNPs associated with TG in normolipidemic samples, including APOA5 p.S19W and -1131T>C, TRIB1 rs17321515, TBL2 rs17145738, GCKR rs780094, GALNT2 rs4846914 and ANGPTL3 rs12130333, were significantly associated ..

More Information

Publications106 found, 100 shown here

  1. Kraja A, Vaidya D, Pankow J, Goodarzi M, Assimes T, Kullo I, et al. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes. 2011;60:1329-39 pubmed publisher
    ..Variants in the genes LPL, CETP, APOA5 (and its cluster), GCKR (and its cluster), LIPC, TRIB1, LOC100128354/MTNR1B, ABCB11, and LOC100129150 were further tested for their association with individual ..
  2. Soubeyrand S, Naing T, Martinuk A, McPherson R. ERK1/2 regulates hepatocyte Trib1 in response to mitochondrial dysfunction. Biochim Biophys Acta. 2013;1833:3405-3414 pubmed publisher
    The TRIB1 locus (8q24.13) is a novel locus identified and replicated by several genome-wide association studies for associations with plasma triglycerides, apolipoprotein B and coronary artery disease...
  3. Varbo A, Benn M, Tybjærg Hansen A, Grande P, Nordestgaard B. TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population. Arterioscler Thromb Vasc Biol. 2011;31:451-7 pubmed publisher
    The goal of this study was to test whether TRIB1-rs2954029 and GCKR-rs1260326 associate with lipid levels and risk of ischemic heart disease (IHD) and myocardial infarction (MI) in the general population...
  4. Ishizuka Y, Nakayama K, Ogawa A, Makishima S, Boonvisut S, Hirao A, et al. TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions. J Mol Endocrinol. 2014;52:145-58 pubmed publisher
    Mammalian tribbles homolog 1 (TRIB1) regulates hepatic lipogenesis and is genetically associated with plasma triglyceride (TG) levels and cholesterol, but the molecular mechanisms remain obscure...
  5. Cai W, Weng D, Yan P, Lin Y, Dong Z, Mailamuguli -, et al. Genetic polymorphisms associated with nonalcoholic fatty liver disease in Uyghur population: a case-control study and meta-analysis. Lipids Health Dis. 2019;18:14 pubmed publisher
    ..Here, we accessed the seven polymorphisms of rs1260326, rs780094 in GCKR, rs2954021 near TRIB1, rs2228603 in NCAN, rs58542926 in TM6SF2, rs12137855 near LYPLAL1, and rs10883437 near CPN1 on NAFLD ..
  6. Munkley J, Lafferty N, Kalna G, Robson C, Leung H, Rajan P, et al. Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells. BMC Cancer. 2015;15:9 pubmed publisher
    ..We find the PTGER4 and TSPYL2 genes are up-regulated by androgen stimulation and the ADCY1, OPKR1, TRIB1, SPRY1 and PTPRR are down-regulated by androgens...
  7. Jamieson S, Ruan Z, Burgess A, Curry J, McMillan H, Brewster J, et al. Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1. Sci Signal. 2018;11: pubmed publisher
    ..We found that the TRIB1 pseudokinase was able to recruit various C/EBP family members and that the binding of C/EBPβ was attenuated by ..
  8. Kung J, Jura N. The pseudokinase TRIB1 toggles an intramolecular switch to regulate COP1 nuclear export. EMBO J. 2019;38: pubmed publisher
    ..Here, we report that, in addition to this scaffolding role, TRIB1 promotes nuclear localization of COP1 by disrupting an intramolecular interaction between the WD40 domain and a ..
  9. Börnigen D, Tyekucheva S, Wang X, Rider J, Lee G, Mucci L, et al. Computational Reconstruction of NF?B Pathway Interaction Mechanisms during Prostate Cancer. PLoS Comput Biol. 2016;12:e1004820 pubmed publisher
    ..We identified novel roles for ATF3, CXCL2, DUSP5, JUNB, NEDD9, SELE, TRIB1, and ZFP36 in this pathway, in addition to new mechanistic interactions between these genes and 10 known NF?B ..
  10. Lin S, Liu Y, Goldin L, Lyu C, Kong X, Zhang Y, et al. Sex-related DNA methylation differences in B cell chronic lymphocytic leukemia. Biol Sex Differ. 2019;10:2 pubmed publisher
    ..Among them, TRIB1, an autosome gene, has been shown to promote tumor growth by suppressing apoptosis...
  11. Jin J, Sun D, Cao Y, Zhang H, Guo Y, Wu N, et al. Intensive genetic analysis for Chinese patients with very high triglyceride levels: Relations of mutations to triglyceride levels and acute pancreatitis. EBioMedicine. 2018;38:171-177 pubmed publisher
    ..genetic sequencing including 15 TG-related genes (LPL, LMF1, APOC2, GPIHBP1, GCKR, ANGPTL3, APOB, APOA1-A4-C3-A5, TRIB1, CETP, APOE, and LIPI) was performed within 103 patients who were diagnosed with primary SHTG and 46 age- and sex-..
  12. Medina Gali R, Bello Perez M, Ciordia S, Mena M, Coll J, Novoa B, et al. Plasma proteomic analysis of zebrafish following spring viremia of carp virus infection. Fish Shellfish Immunol. 2019;86:892-899 pubmed publisher
    ..Real-time RT-PCR evaluation of samples from internal organs verified that SVCV infection induced vtg and gig2 gene expression already at day 1 post-infection...
  13. Liu L, Fox C, North T, Goessling W. Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development. Dis Model Mech. 2013;6:1271-8 pubmed publisher
    ..pklr and mapk10) decreased expression of hepatic progenitor cells, whereas knockdown of eight genes (pnpla3, cpn1, trib1, fads2, slc2a2, pklr, mapk10 and samm50) decreased cell-specific hepatocyte expression...
  14. Dikopoltsev E, Foltyn V, Zehl M, Jensen O, Mori H, Radzishevsky I, et al. FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine. J Biol Chem. 2014;289:33904-15 pubmed publisher
    ..Although FBXO22 is classically associated with the ubiquitin system and is recruited to the Skip1-Cul1-F-box E3 complex, SR interacts preferentially with free FBXO22 species...
  15. Nagiec M, Duvall J, Skepner A, Howe E, Bastien J, Comer E, et al. Novel tricyclic glycal-based TRIB1 inducers that reprogram LDL metabolism in hepatic cells. Medchemcomm. 2018;9:1831-1842 pubmed publisher
    Increased expression of the Tribbles pseudokinase 1 gene (TRIB1) is associated with lower plasma levels of LDL cholesterol and triglycerides, higher levels of HDL cholesterol and decreased risk of coronary artery disease and ..
  16. Deo R, Reich D, Tandon A, Akylbekova E, Patterson N, Waliszewska A, et al. Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study. PLoS Genet. 2009;5:e1000342 pubmed publisher
  17. de Castro Orós I, Cenarro A, Tejedor M, Baila Rueda L, Mateo Gallego R, Lamiquiz Moneo I, et al. Common genetic variants contribute to primary hypertriglyceridemia without differences between familial combined hyperlipidemia and isolated hypertriglyceridemia. Circ Cardiovasc Genet. 2014;7:814-21 pubmed publisher
    ..variants were positively correlated with plasma triglycerides, whereas minor alleles of ADIPOR2, ANGPTL3, LPL, and TRIB1 polymorphisms were inversely associated...
  18. Neuwirt H, Perco P, Kainz A, Mühlberger I, Leierer J, Braniff S, et al. A 3-biomarker-panel predicts renal outcome in patients with proteinuric renal diseases. BMC Med Genomics. 2014;7:75 pubmed publisher
    ..correlated to each other by > 50% we identified VEGF-C from the CREDI panel and BMP7, THBS1, and TRIB1 from the INSCO panel...
  19. Guo L, Guo Z, Gong H, Shang Y, Zhong M, Zhang Y, et al. Tribbles homolog 3 is induced by high glucose and associated with apoptosis in human endothelial cells. Mol Med Rep. 2015;12:1963-70 pubmed publisher
    ..5, 10, 20, 30 and 40 mmol/l) were assessed for mRNA expression of TRIB1, TRIB2 and TRIB3 using reverse transcription quantitative polymerase chain reaction...
  20. Wang L, Jing J, Fu Q, Tang X, Su L, Wu S, et al. Association study of genetic variants at newly identified lipid gene TRIB1 with coronary heart disease in Chinese Han population. Lipids Health Dis. 2015;14:46 pubmed publisher
    Recent genome-wide association studies (GWAS) have identified the variants near TRIB1 gene affecting blood lipid levels. However, the association between the reported variants and risk of coronary heart disease (CHD) was not confirmed...
  21. Arndt L, Dokas J, Gericke M, Kutzner C, Müller S, Jeromin F, et al. Tribbles homolog 1 deficiency modulates function and polarization of murine bone marrow-derived macrophages. J Biol Chem. 2018;293:11527-11536 pubmed publisher
    ..b>Tribbles homolog 1 (Trib1), a member of the mammalian Tribbles homolog pseudokinase family, has been implicated in ..
  22. Jeemon P, Pettigrew K, Sainsbury C, Prabhakaran D, Padmanabhan S. Implications of discoveries from genome-wide association studies in current cardiovascular practice. World J Cardiol. 2011;3:230-47 pubmed publisher
    ..CELSR2, PSRC1 and SORT1 genes have been associated with CHD, and TMEM57, DOCK7, CELSR2, APOB, ABCG5, HMGCR, TRIB1, FADS2/S3, LDLR, NCAN and TOMM40-APOE with total cholesterol...
  23. Zhang C, Elkahloun A, Liao H, Delaney S, Saber B, Morrow B, et al. Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells. Mol Cancer Ther. 2011;10:1137-48 pubmed publisher
    ..those induced by PIAs only (DUSP1, KLF6, CENTD2, BHLHB2, and PREX1), those commonly induced by PIAs and LY (TRIB1, KLF2, RHOB, and CDKN1A), and those commonly suppressed by PIAs and LY (IGFBP3, PCNA, PRIM1, MCM3, and HSPA1B)...
  24. Chen H, Sun C, Liu W, Gu M, Lin G, Liu Y, et al. Promoter analysis and transcriptional regulation of a Gig2 gene in grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2015;42:249-55 pubmed publisher
    Grass carp reovirus (GCRV)-induced gene 2 (Gig2) is recognized as a new antiviral factor involved in response to viral infection...
  25. Aravind L, Zhang D, de Souza R, Anand S, Iyer L. The natural history of ADP-ribosyltransferases and the ADP-ribosylation system. Curr Top Microbiol Immunol. 2015;384:3-32 pubmed publisher
    ..g., pierisin and CARP-1 families) or immunity-related proteins (e.g., Gig2-like ARTs)...
  26. Friedman A. C/EBPα in normal and malignant myelopoiesis. Int J Hematol. 2015;101:330-41 pubmed publisher
    ..RUNX1 mutation, CEBPA promoter methylation, Trib1 or Trib2-mediated C/EBPαp42 degradation, and signaling pathways leading to C/EBPα serine 21 phosphorylation ..
  27. Nagiec M, Skepner A, Negri J, Eichhorn M, Kuperwasser N, Comer E, et al. Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. PLoS ONE. 2015;10:e0120295 pubmed publisher
    Recent genome wide association studies have linked tribbles pseudokinase 1 (TRIB1) to the risk of coronary artery disease (CAD)...
  28. Salomè M, Hopcroft L, Keeshan K. Inverse and correlative relationships between TRIBBLES genes indicate non-redundant functions during normal and malignant hemopoiesis. Exp Hematol. 2018;66:63-78.e13 pubmed publisher
    TRIBBLES pseudokinases (TRIB1, TRIB2, and TRIB3) are important regulators of normal and malignant hemopoiesis. The relative abundance of each TRIBBLES family member may be important for distinct oncogenic or tumor suppressor functions...
  29. Kraja A, Chasman D, North K, Reiner A, Yanek L, Kilpeläinen T, et al. Pleiotropic genes for metabolic syndrome and inflammation. Mol Genet Metab. 2014;112:317-38 pubmed publisher
  30. Sümegi K, Jaromi L, Magyari L, Kovesdi E, Duga B, Szalai R, et al. Functional variants of lipid level modifier MLXIPL, GCKR, GALNT2, CILP2, ANGPTL3 and TRIB1 genes in healthy Roma and Hungarian populations. Pathol Oncol Res. 2015;21:743-9 pubmed publisher
    ..Our goal was to examine eight variants: rs12130333 at the ANGPTL3, rs16996148 at the CILP2, rs17321515 at the TRIB1, rs17145738 and rs3812316 of the MLXIPL, rs4846914 at GALNT2, rs1260326 and rs780094 residing at the GCKR loci...
  31. Chambers J, Zhang W, Sehmi J, Li X, Wass M, van der Harst P, et al. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet. 2011;43:1131-8 pubmed publisher
    ..glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and ..
  32. Murphy J, Nakatani Y, Jamieson S, Dai W, Lucet I, Mace P. Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase. Structure. 2015;23:2111-21 pubmed publisher
    ..Here, we present the first crystal structure of a Tribbles protein, which reveals a catalytically inactive TRIB1 pseudokinase domain with a unique adaptation in the αC helix...
  33. Gao F, Wang Y, Zhang Q, Mou C, Li Z, Deng Y, et al. Distinct herpesvirus resistances and immune responses of three gynogenetic clones of gibel carp revealed by comprehensive transcriptomes. BMC Genomics. 2017;18:561 pubmed publisher
    ..IFNphi3, IFI44-like and Gig2 displayed the highest expression in clone F and IRF1 uniquely increased in susceptible clone A+...
  34. Soubeyrand S, Martinuk A, Naing T, Lau P, McPherson R. Role of Tribbles Pseudokinase 1 (TRIB1) in human hepatocyte metabolism. Biochim Biophys Acta. 2016;1862:223-32 pubmed publisher
    ..studies for plasma triglycerides and hepatic steatosis identified a risk locus on chromosome 8q24 close to the TRIB1 gene, encoding Tribbles Pseudokinase 1 (TRIB1)...
  35. Bhairavabhotla R, Kim Y, Glass D, Escobar T, Patel M, Zahr R, et al. Transcriptome profiling of human FoxP3+ regulatory T cells. Hum Immunol. 2016;77:201-13 pubmed publisher
    ..Notably, a number of yet uncharacterized genes (RTKN2, LAYN, UTS2, CSF2RB, TRIB1, F5, CECAM4, CD70, ENC1 and NKG7) were identified and validated as being differentially expressed in human Tregs...
  36. Lech K, Ackermann K, Revell V, Lao O, Skene D, Kayser M. Dissecting Daily and Circadian Expression Rhythms of Clock-Controlled Genes in Human Blood. J Biol Rhythms. 2016;31:68-81 pubmed publisher
    ..Blood expression levels of 9 candidate CCGs (SREBF1, TRIB1, USF1, THRA1, SIRT1, STAT3, CAPRIN1, MKNK2, and ROCK2), were measured across 48 h in 12 participants in the S/SD ..
  37. Eyers P. TRIBBLES: A Twist in the Pseudokinase Tail. Structure. 2015;23:1974-6 pubmed publisher
    b>TRIB1, a homolog of Drosophila Tribbles, regulates the stability of transcription factors through physical interaction with the ubiquitin E3 ligase COP1. In this issue of Structure, Murphy et al...
  38. Weissglas Volkov D, Aguilar Salinas C, Sinsheimer J, Riba L, Huertas Vazquez A, Ordoñez Sánchez M, et al. Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. Circ Cardiovasc Genet. 2010;3:31-8 pubmed publisher
    ..were within or near the genes ABCA1, ANGPTL3, APOA5, APOB, CETP, GALNT2, GCKR, LCAT, LIPC, LPL (2), MMAB-MVK, TRIB1, and XKR6-AMAC1L2...
  39. Ko A, Cantor R, Weissglas Volkov D, Nikkola E, Reddy P, Sinsheimer J, et al. Amerindian-specific regions under positive selection harbour new lipid variants in Latinos. Nat Commun. 2014;5:3983 pubmed publisher
    ..These findings suggest that Amerindian-specific genetic architecture leads to a higher incidence of dyslipidemia and obesity in modern Mexicans. ..
  40. Ma D, Liu T, Chang L, Rui C, Xiao Y, Li S, et al. The Liver Clock Controls Cholesterol Homeostasis through Trib1 Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR) Axis. J Biol Chem. 2015;290:31003-12 pubmed publisher
    ..of lipid-associated genes in the liver and markedly reduced the expression of the non-rhythmically expressed gene Trib1. Adenovirus-mediated rescue of Trib1 expression lowered plasma PCSK9 levels, increased LDL receptor protein ..
  41. Shiraishi M, Shintani Y, Shintani Y, Ishida H, Saba R, Yamaguchi A, et al. Alternatively activated macrophages determine repair of the infarcted adult murine heart. J Clin Invest. 2016;126:2151-66 pubmed publisher
    ..We evaluated mice lacking the kinase TRIB1 (Trib1-/-), which exhibit a selective depletion of M2 macrophages after MI...
  42. Tang K, Finley R, Nie D, Honn K. Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening. Biochemistry. 2000;39:3185-91 pubmed
    ..We identified type II keratin 5, lamin A, the cytoplasmic domain of integrin beta4 subunit and a phosphoprotein C8FW as 12-LOX interacting proteins...
  43. Garcia Rios A, Perez Martinez P, Mata P, Fuentes F, Lopez Miranda J, Alonso R, et al. Polymorphism at the TRIB1 gene modulates plasma lipid levels: insight from the Spanish familial hypercholesterolemia cohort study. Nutr Metab Cardiovasc Dis. 2011;21:957-63 pubmed publisher
    ..Therefore, our aims were to assess the association of the rs17321515 (TRIB1) SNP with plasma lipids concentrations and anthropometric variables and to explore the interaction between this ..
  44. Bauer R, Sasaki M, Cohen D, Cui J, Smith M, Yenilmez B, et al. Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα. J Clin Invest. 2015;125:3809-18 pubmed publisher
    Variants near the gene TRIB1 are significantly associated with several plasma lipid traits, circulating liver enzymes, and the development of coronary artery disease in humans; however, it is not clear how its protein product tribbles-1 ..
  45. Soubeyrand S, Martinuk A, McPherson R. TRIB1 is a positive regulator of hepatocyte nuclear factor 4-alpha. Sci Rep. 2017;7:5574 pubmed publisher
    The TRIB1 locus has been linked to both cardiovascular disease and hepatic steatosis. Recent efforts have revealed TRIB1 to be a major regulator of liver function, largely, but not exclusively, via CEBPA degradation...
  46. Briffa R, Um I, Faratian D, Zhou Y, Turnbull A, Langdon S, et al. Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers. PLoS ONE. 2015;10:e0144708 pubmed publisher
    ..Frequently gained regions contained EGFR, PIK3CA, MYC, SMO, TRIB1, FZD1, and BRCA2, while frequently lost regions contained FHIT and MACROD2. TRIB1 was selected for further study...
  47. Grove J, Austin M, Tibble J, Aithal G, Verma S.  Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms?. Ann Hepatol. 2016;15:277-82 pubmed publisher
    ..Genotyping revealed multiple single nucleotide polymorphisms at 9 independent loci in genes PNPLA3, APOC3, GCKR, TRIB1, LYPLAL1, PPP1R3B, COL13A1, and EFCAB4B, previously implicated in contributing to non-alcoholic steatohepatitis ..
  48. Durzynska I, Xu X, Adelmant G, Ficarro S, Marto J, Sliz P, et al. STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1. Structure. 2017;25:287-294 pubmed publisher
    ..Although the structure of the kinase homology domain diverges from the analogous region of Trib1, the results reported here suggest functional parallels between STK40 and Tribbles-family proteins as COP1 ..
  49. Liang K, Rishi L, Keeshan K. Tribbles in acute leukemia. Blood. 2013;121:4265-70 pubmed publisher
    ..We discuss the role of Tribs as central signaling mediators in different subtypes of acute leukemia and propose that inhibition of dysregulated Trib signaling may be therapeutically beneficial. ..
  50. Zhou L, He M, Mo Z, Wu C, Yang H, Yu D, et al. A genome wide association study identifies common variants associated with lipid levels in the Chinese population. PLoS ONE. 2013;8:e82420 pubmed publisher
    ..The results from our GWAS provided comprehensive and convincing evidence of the genetic determinants of plasma lipid levels in a Chinese population. ..
  51. Ikeoka T, Hayashida N, Nakazato M, Sekita T, Murata Mori F, Ando T, et al. The A>T polymorphism of the tribbles homolog 1 gene is associated with serum triglyceride concentrations in Japanese community-dwelling women. Tohoku J Exp Med. 2014;233:149-53 pubmed
    Recent genome-wide association studies have identified Tribbles homolog 1 (TRIB1) as one of the candidate genes associated with lipid profiles. TRIB1 is known to interact with MAP kinases, thereby regulating their activities...
  52. Miyajima C, Inoue Y, Hayashi H. Pseudokinase tribbles 1 (TRB1) negatively regulates tumor-suppressor activity of p53 through p53 deacetylation. Biol Pharm Bull. 2015;38:618-24 pubmed publisher
    Tribbles 1 (TRB1) is one of the mammalian orthologs of Drosophila Tribbles, which regulates development and cell proliferation. TRB1 is suggested to act as a scaffold protein in signaling pathways for important cellular processes...
  53. Kiss Toth E, Velasco G, Pear W. Tribbles at the cross-roads…. Biochem Soc Trans. 2015;43:1049-50 pubmed publisher
  54. Dedhia P, Keeshan K, ULJON S, Xu L, Vega M, Shestova O, et al. Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. Blood. 2010;116:1321-8 pubmed publisher
    b>Trib1, Trib2, and Trib3 are mammalian homologs of Tribbles, an evolutionarily conserved Drosophila protein family that mediates protein degradation...
  55. Yokoyama T, Toki T, Aoki Y, Kanezaki R, Park M, Kanno Y, et al. Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia. Blood. 2012;119:2608-11 pubmed publisher
    b>Trib1 has been identified as a myeloid oncogene in a murine leukemia model. Here we identified a TRIB1 somatic mutation in a human case of Down syndrome-related acute megakaryocytic leukemia...
  56. Kitamoto A, Kitamoto T, Nakamura T, Ogawa Y, Yoneda M, Hyogo H, et al. Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver disease and metabolic syndrome traits. Endocr J. 2014;61:683-9 pubmed
    ..variants have been identified in several genes, including LYPLAL1, ZP4, GCKR, HSD17B13, PALLD, PPP1R3B, FDFT1, TRIB1, COL13A1, CPN1, ERLIN1, CWF19L1, EFCAB4B, PZP, and NCAN...
  57. Douvris A, Soubeyrand S, Naing T, Martinuk A, Nikpay M, Williams A, et al. Functional analysis of the TRIB1 associated locus linked to plasma triglycerides and coronary artery disease. J Am Heart Assoc. 2014;3:e000884 pubmed publisher
    The TRIB1 locus has been linked to hepatic triglyceride metabolism in mice and to plasma triglycerides and coronary artery disease in humans...
  58. Hegedus Z, Czibula A, Kiss Toth E. Tribbles: novel regulators of cell function; evolutionary aspects. Cell Mol Life Sci. 2006;63:1632-41 pubmed
    ..This review summarises our current understanding of tribbles function and also provides an evolutionary perspective on the various tribbles genes. ..
  59. Jaromi L, Csongei V, Polgar N, Rappai G, Szolnoki Z, Maasz A, et al. Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke. Neuromolecular Med. 2011;13:179-86 pubmed publisher
    ..rs12130333 located within the ANGPTL3 locus; rs16996148 residing at the CILP2 gene locus; and rs17321515 at the TRIB1 locus, which were originally reported in association with decreased triglyceride levels; therefore, we ..
  60. Dugast E, Kiss Toth E, Docherty L, Danger R, Chesneau M, Pichard V, et al. Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells. J Biol Chem. 2013;288:10051-60 pubmed publisher
    In a previous study, we identified TRIB1, a serine-threonine kinase-like molecule, as a biomarker of chronic antibody-mediated rejection of human kidneys when measured in peripheral blood mononuclear cells...
  61. Varga T, Sonestedt E, Shungin D, Koivula R, Hallmans G, Escher S, et al. Genetic determinants of long-term changes in blood lipid concentrations: 10-year follow-up of the GLACIER study. PLoS Genet. 2014;10:e1004388 pubmed publisher
    ..12 mmol/l per effect allele per decade follow-up, P = 2.0 × 10(-5)), and two TG loci, tribbles pseudokinase 1 (TRIB1) rs2954029 (? = 0.09 mmol/l per effect allele per decade follow-up, P = 5...
  62. Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, et al. Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 2014;26:222-34 pubmed publisher
    ..These findings expand the list of potential COP1 substrates to include proteins whose COP1-binding sites are subject to regulatory phosphorylation and provide insights into transformation by Src family kinases. ..
  63. Ye Y, Wang G, Wang G, Zhuang J, He S, Song Y, et al. The Oncogenic Role of Tribbles 1 in Hepatocellular Carcinoma Is Mediated by a Feedback Loop Involving microRNA-23a and p53. Front Physiol. 2017;8:789 pubmed publisher
    ..Here, we examined the involvement of the pseudokinase Tribbles 1 (TRIB1), a scaffold protein associated with several malignancies, in HCC and investigated the underlying mechanisms...
  64. Danger R, Dugast E, Braza F, Conchon S, Brouard S. Deciphering the role of TRIB1 in regulatory T-cells. Biochem Soc Trans. 2015;43:1075-8 pubmed publisher
    ..We reported on the overexpression of tribbles-1 (TRIB1) in Tregs compared with their counterpart naive T-cells and that TRIB1 interacts with the master molecule of Tregs,..
  65. Yao C, Joehanes R, Johnson A, Huan T, Liu C, Freedman J, et al. Dynamic Role of trans Regulation of Gene Expression in Relation to Complex Traits. Am J Hum Genet. 2017;100:571-580 pubmed publisher
    ..several cis-eGenes (ALDH2 for systolic and diastolic blood pressure, MCM6 and DARS for total cholesterol, and TRIB1 for triglycerides) that were causal mediators for the corresponding traits, as well as examples of trans-mediators ..
  66. Xu C, Zhang J, Huang X, Sun J, Xu Y, Tang Y, et al. Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP. J Biol Chem. 2006;281:15900-8 pubmed
    ..The biological implication of this binding with spliceosome rearrangement during activation is discussed. ..
  67. Gilby D, Sung H, Winship P, Goodeve A, Reilly J, Kiss Toth E. Tribbles-1 and -2 are tumour suppressors, down-regulated in human acute myeloid leukaemia. Immunol Lett. 2010;130:115-24 pubmed publisher
    ..This may lead to enhanced cell survival, and therefore contribute to pathogenesis of the disease. Trb-1/trb-2 may, therefore, represent useful therapeutic targets for the treatment of AML in patients with dys-regulated trb activity. ..
  68. Yokoyama T, Kanno Y, Yamazaki Y, Takahara T, Miyata S, Nakamura T. Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis. Blood. 2010;116:2768-75 pubmed publisher
    b>Trib1 is a myeloid oncogene that cooperates with Hoxa9 and Meis1...
  69. ULJON S, Xu X, Durzynska I, Stein S, Adelmant G, Marto J, et al. Structural Basis for Substrate Selectivity of the E3 Ligase COP1. Structure. 2016;24:687-696 pubmed publisher isolation, and complexes of the human and Arabidopsis thaliana COP1 WD40 domains with the binding motif of Trib1. The human and Arabidopsis WD40 domains are seven-bladed ? propellers with an inserted loop on the bottom face of ..
  70. Willer C, Mohlke K. Finding genes and variants for lipid levels after genome-wide association analysis. Curr Opin Lipidol. 2012;23:98-103 pubmed publisher
    ..Experimental follow-up of three loci identified by GWAS has identified functional genes GALNT2, TRIB1, and SORT1, and a functional variant at SORT1...
  71. Lin Z, Huang Y, Zhang Y, Han Z, He H, Ling X, et al. MicroRNA-224 inhibits progression of human prostate cancer by downregulating TRIB1. Int J Cancer. 2014;135:541-50 pubmed publisher
    ..In this study, we identified TRIB1 as a target gene of miR-224...
  72. Foulkes D, Byrne D, Bailey F, Eyers P. Tribbles pseudokinases: novel targets for chemical biology and drug discovery?. Biochem Soc Trans. 2015;43:1095-103 pubmed publisher
    ..We predict that appropriate small molecule TRIB ligands will further accelerate the transition of TRIB pseudokinase analysis into the mainstream of cell signalling. ..
  73. Iwamoto S, Boonvisut S, Makishima S, Ishizuka Y, Watanabe K, Nakayama K. The role of TRIB1 in lipid metabolism; from genetics to pathways. Biochem Soc Trans. 2015;43:1063-8 pubmed publisher
    ..Mammalian tribbles homologue 1 (TRIB1) is a human locus, the downstream linkage disequilibrium (LD) block of which affects plasma low-density ..
  74. Basatvat S, Carter D, Kiss Toth E, Fazeli A. Tribbles role in reproduction. Biochem Soc Trans. 2015;43:1116-21 pubmed publisher
    ..Therefore, control mechanisms regulating the innate immune system function can be critical for successful reproductive events. ..
  75. Shintani Y, Ito T, Fields L, Shiraishi M, Ichihara Y, Sato N, et al. IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice. Sci Rep. 2017;7:6877 pubmed publisher
    ..Experiments using Trib1 -/- mice that had a depleted ability to develop M2 macrophages and other in-vitro studies supported ..
  76. Keebler M, Deo R, Surti A, Konieczkowski D, Guiducci C, Burtt N, et al. Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. Circ Cardiovasc Genet. 2010;3:358-64 pubmed publisher
    ..To further evaluate these loci, fine-mapping in larger African American cohorts and/or resequencing will be required. ..
  77. Dastani Z, Hivert M, Timpson N, Perry J, Yuan X, Scott R, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 2012;8:e1002607 pubmed publisher
    ..4×10(-4), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance. ..
  78. Stein S, Mack E, Rome K, Pear W. Tribbles in normal and malignant haematopoiesis. Biochem Soc Trans. 2015;43:1112-5 pubmed publisher
    ..The three mammalian Tribbles homologues, Trib1, Trib2 and Trib3 are characterized by conserved motifs, including a pseudokinase domain and a C-terminal E3 ligase-..
  79. Tang B, Wu W, Zhang Q, Sun Y, Cui Y, Wu F, et al. Inhibition of tribbles protein-1 attenuates radioresistance in human glioma cells. Sci Rep. 2015;5:15961 pubmed publisher
    ..The results showed that human glioma cells expressed a low level of Trib1, which was significantly up regulated by exposure to small doses (2 Gy/day for 4 days) of irradiation...
  80. Rey S, Moiche V, Boltaña S, Teles M, MacKenzie S. Behavioural fever in zebrafish larvae. Dev Comp Immunol. 2017;67:287-292 pubmed publisher
    ..In parallel we measured the abundance of antiviral transcripts; viperin, gig2, irf7, trim25 and Mxb mRNAs in dsRNA challenged larvae under both thermal regimes: TR and TCh...
  81. Lai J, Moya L, An J, Hoffman A, Srinivasan S, Panchadsaram J, et al. A microsatellite repeat in PCA3 long non-coding RNA is associated with prostate cancer risk and aggressiveness. Sci Rep. 2017;7:16862 pubmed publisher
    ..Our analysis indicated that three of these STRs (TAAA-ACTG2, TTTTG-TRIB1, and TG-PCA3) are polymorphic and differentially expressed in prostate tumors compared to adjacent non-malignant ..
  82. Keeshan K, Vieugué P, Chaudhury S, Rishi L, Gaillard C, Liang L, et al. Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBP? as a common target of TRIB1 and PML/RARA. Haematologica. 2016;101:1228-1236 pubmed
    ..that gain of chromosome 8-containing MYC is of central importance in trisomy 8, but the role of the nearby TRIB1 gene has not been experimentally addressed in this context...
  83. Wang Y, Wu N, Pang B, Tong D, Sun D, Sun H, et al. TRIB1 promotes colorectal cancer cell migration and invasion through activation MMP-2 via FAK/Src and ERK pathways. Oncotarget. 2017;8:47931-47942 pubmed publisher
    ..In the present study, a putative oncogene at 8q24, TRIB1, was characterized for its role in CRC metastasis and underlying molecular mechanisms...
  84. Aung L, Yin R, Wu D, Li Q, Yan T, Wang Y, et al. Association of the TRIB1 tribbles homolog 1 gene rs17321515 A>G polymorphism and serum lipid levels in the Mulao and Han populations. Lipids Health Dis. 2011;10:230 pubmed publisher
    The association of rs17321515 single nucleotide polymorphism (SNP) near TRIB1 gene and serum lipid profiles has never been studied in the Chinese population...
  85. Ollila H, Utge S, Kronholm E, Aho V, Van Leeuwen W, Silander K, et al. TRIB1 constitutes a molecular link between regulation of sleep and lipid metabolism in humans. Transl Psychiatry. 2012;2:e97 pubmed publisher
    ..The genetic analysis identified two variants near TRIB1 gene that independently contributed to both blood lipid levels and to TST (rs17321515, P = 8...
  86. Lu X, Hu J, Fang Y, Wang Z, Xie J, Zhan Q, et al. A case-control study indicates that the TRIB1 gene is associated with pancreatic cancer. Genet Mol Res. 2014;13:6142-7 pubmed publisher
    ..To investigate whether the tribbles homolog 1 (Drosophila) gene (TRIB1) is associated with pancreatic cancer in the Chinese Han population, we conducted ..
  87. Gendelman R, Xing H, Mirzoeva O, Sarde P, Curtis C, Feiler H, et al. Bayesian Network Inference Modeling Identifies TRIB1 as a Novel Regulator of Cell-Cycle Progression and Survival in Cancer Cells. Cancer Res. 2017;77:1575-1585 pubmed publisher
    ..such as CCND1, CCNE2, and CDC25A, as well as revealed novel regulators of G1-S transition, IER2, TRIB1, TRIM27...
  88. Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, et al. Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency. J Exp Med. 2007;204:2233-9 pubmed
    ..b>Trib1 is reportedly involved in the regulation of NF-kappaB and MAP kinases, as well as gene expression in vitro...
  89. Johnston J, Basatvat S, Ilyas Z, Francis S, Kiss Toth E. Tribbles in inflammation. Biochem Soc Trans. 2015;43:1069-74 pubmed publisher
    ..This review summarizes our current knowledge on TRIBs in the context of inflammation, both at the level of molecular mechanisms and in disease development. ..
  90. Bauer R, Yenilmez B, Rader D. Tribbles-1: a novel regulator of hepatic lipid metabolism in humans. Biochem Soc Trans. 2015;43:1079-84 pubmed publisher
    The protein tribbles-1, encoded by the gene TRIB1, is increasingly recognized as a major regulator of multiple cellular and physiological processes in humans...
  91. Imajo M, Nishida E. Human Tribbles homolog 1 functions as a negative regulator of retinoic acid receptor. Genes Cells. 2010;15:1089-97 pubmed
    ..In this study, we uncover a novel function of human Tribbles homolog 1 (Trib1) as a regulator of retinoic acid receptor (RAR) signaling...
  92. Mashima T, Soma Nagae T, Migita T, Kinoshita R, Iwamoto A, Yuasa T, et al. TRIB1 supports prostate tumorigenesis and tumor-propagating cell survival by regulation of endoplasmic reticulum chaperone expression. Cancer Res. 2014;74:4888-97 pubmed publisher
    ..Here, we applied a functional genomic approach to the 3D spheroid cell culture model and identified TRIB1, a member of the Trib family of serine/threonine kinase-like proteins, as an essential factor for prostate cancer ..