TREX1

Summary

Gene Symbol: TREX1
Description: three prime repair exonuclease 1
Alias: AGS1, CRV, DRN3, HERNS, three-prime repair exonuclease 1, 3' repair exonuclease 1, 3'-5' exonuclease TREX1, DNase III, deoxyribonuclease III
Species: human

Top Publications

  1. pmc The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
    Nan Yan
    Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:1005-13. 2010
  2. doi Trex-1 deficiency in rheumatoid arthritis synovial fibroblasts
    Michel Neidhart
    Center for Experimental Rheumatology, Zurich Center for Integrative Human Physiology, Zurich, Switzerland
    Arthritis Rheum 62:2673-9. 2010
  3. ncbi Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases
    D J Mazur
    Wake Forest University School of Medicine, Department of Biochemistry, Winston Salem, North Carolina 27157, USA
    J Biol Chem 274:19655-60. 1999
  4. pmc A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein
    M Hoss
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    EMBO J 18:3868-75. 1999
  5. ncbi Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins
    D J Mazur
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 276:17022-9. 2001
  6. ncbi Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus
    Yanick J Crow
    Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    Nat Genet 38:917-20. 2006
  7. ncbi The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering
    Udesh de Silva
    Department of Biochemistry, Center for Structural Biology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157
    J Biol Chem 282:10537-43. 2007
  8. pmc Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome
    Gillian Rice
    Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, LS9 7TF, UK
    Am J Hum Genet 80:811-5. 2007
  9. ncbi A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus
    Min Ae Lee-Kirsch
    Klinik fur Kinder und Jugendmedizin, Technische Universitat Dresden, Fetscherstr 74, 01307, Dresden, Germany
    J Mol Med (Berl) 85:531-7. 2007
  10. ncbi Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus
    Min Ae Lee-Kirsch
    Klinik fur Kinder und Jugendmedizin, Technische Universitat Dresden, 01307 Dresden, Germany
    Nat Genet 39:1065-7. 2007

Research Grants

  1. Understanding the role of TREX1 in the innate immunity and autoimmune diseases
    Nan Yan; Fiscal Year: 2012
  2. Granzyme a Pathway of CTL-Mediated Cell Death
    Judy Lieberman; Fiscal Year: 2010
  3. Judy Lieberman; Fiscal Year: 2016
  4. Mechanisms of the 3'-->5'deoxyribonucleases
    Fred W Perrino; Fiscal Year: 2012
  5. Daniel B Stetson; Fiscal Year: 2016
  6. Nan Yan; Fiscal Year: 2016
  7. Pathobiology of Retinal Vasculopathy with Cerebal Leukodystrophy (RVCL)
    Joanna C Jen; Fiscal Year: 2010
  8. MATTHIAS R WABL; Fiscal Year: 2014
  9. Improving Animal Resources at the University of Georgia
    CHRISTOPHER SIMON KING; Fiscal Year: 2012
  10. AGS4 in G-protein Signal Processing
    Joe B Blumer; Fiscal Year: 2013

Detail Information

Publications180 found, 100 shown here

  1. pmc The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
    Nan Yan
    Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:1005-13. 2010
    ..How HIV avoids activating nucleic acid sensors is unknown. Here we found that the cytosolic exonuclease TREX1 suppressed interferon triggered by HIV...
  2. doi Trex-1 deficiency in rheumatoid arthritis synovial fibroblasts
    Michel Neidhart
    Center for Experimental Rheumatology, Zurich Center for Integrative Human Physiology, Zurich, Switzerland
    Arthritis Rheum 62:2673-9. 2010
    ....
  3. ncbi Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases
    D J Mazur
    Wake Forest University School of Medicine, Department of Biochemistry, Winston Salem, North Carolina 27157, USA
    J Biol Chem 274:19655-60. 1999
    ..We have identified the cDNA sequences encoding two 3'-->5' exonucleases (TREX1 and TREX2) from mammalian cells. The TREX1 and TREX2 proteins are 304 and 236 amino acids in length, respectively...
  4. pmc A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein
    M Hoss
    Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    EMBO J 18:3868-75. 1999
    ..2-21.3. In a reconstituted human DNA repair system containing DNA polymerase beta and DNA ligase III-XRCC1, accurate rejoining of a 3' mismatched base residue at a single-strand break is dependent on addition of the exonuclease...
  5. ncbi Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins
    D J Mazur
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 276:17022-9. 2001
    ..The mammalian TREX1 and TREX2 proteins contain potent 3'-->5' exonucleases capable of functioning in this capacity...
  6. ncbi Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus
    Yanick J Crow
    Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    Nat Genet 38:917-20. 2006
    ..Here, we show that TREX1, encoding the major mammalian 3' --> 5' DNA exonuclease, is the AGS1 gene, and AGS-causing mutations result in ..
  7. ncbi The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering
    Udesh de Silva
    Department of Biochemistry, Center for Structural Biology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157
    J Biol Chem 282:10537-43. 2007
    The TREX1 enzyme processes DNA ends as the major 3' --> 5' exonuclease activity in human cells...
  8. pmc Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome
    Gillian Rice
    Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, LS9 7TF, UK
    Am J Hum Genet 80:811-5. 2007
    b>TREX1 constitutes the major 3'-->5' DNA exonuclease activity measured in mammalian cells. Recently, biallelic mutations in TREX1 have been shown to cause Aicardi-Goutieres syndrome at the AGS1 locus...
  9. ncbi A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus
    Min Ae Lee-Kirsch
    Klinik fur Kinder und Jugendmedizin, Technische Universitat Dresden, Fetscherstr 74, 01307, Dresden, Germany
    J Mol Med (Berl) 85:531-7. 2007
    ..In this study, we report the identification of a heterozygous missense mutation (D18N) in TREX1 encoding the 3'-5'repair exonuclease 1 in affected individuals of the family with chilblain lupus...
  10. ncbi Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus
    Min Ae Lee-Kirsch
    Klinik fur Kinder und Jugendmedizin, Technische Universitat Dresden, 01307 Dresden, Germany
    Nat Genet 39:1065-7. 2007
    b>TREX1 acts in concert with the SET complex in granzyme A-mediated apoptosis, and mutations in TREX1 cause Aicardi-Goutières syndrome and familial chilblain lupus...
  11. ncbi C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy
    Anna Richards
    Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 39:1068-70. 2007
    ..In nine families, we identified heterozygous C-terminal frameshift mutations in TREX1, which encodes a 3'-5' exonuclease...
  12. ncbi Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
    Yun gui Yang
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    Cell 131:873-86. 2007
    b>Trex1 is the major 3' DNA exonuclease in mammalian cells, and mutations in the human TREX1 gene can cause Aicardi-Goutières syndrome, characterized by perturbed immunity...
  13. pmc Trex1 prevents cell-intrinsic initiation of autoimmunity
    Daniel B Stetson
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 134:587-98. 2008
    ..In a screen for proteins relevant to this IFN-stimulatory DNA (ISD) response, we identify 3' repair exonuclease 1 (Trex1)...
  14. pmc The SET complex acts as a barrier to autointegration of HIV-1
    Nan Yan
    Department of Pediatrics, Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 5:e1000327. 2009
    ..reticulum-associated complex that contains 3 DNases (the base excision repair endonuclease APE1, 5'-3' exonuclease TREX1, and endonuclease NM23-H1), inhibits HIV-1 and HIV-2/SIV, but not MLV or ASV, infection...
  15. pmc TREX1 acts in degrading damaged DNA from drug-treated tumor cells
    Chuan Jen Wang
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    DNA Repair (Amst) 8:1179-89. 2009
    The major mammalian exonuclease TREX1 has been proposed to play a role in DNA repair and drug resistance. However, no cellular evidence substantiates this claim. Recent reports indicate TREX1's involvement in autoimmunity...
  16. pmc Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage
    Markus Christmann
    Department of Toxicology, University Medical Center, Obere Zahlbacher Strasse 67, D 55131 Mainz, Germany
    Nucleic Acids Res 38:6418-32. 2010
    ..The experiments revealed a clear up-regulation of the three prime exonuclease I (trex1) mRNA following ultraviolet (UV) light treatment...
  17. pmc Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort
    B Namjou
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Genes Immun 12:270-9. 2011
    ..Rare mutations in the TREX1 gene, the major mammalian 3'-5' exonuclease, have been reported in sporadic SLE cases...
  18. doi A homozygous NOTCH3 mutation p.R544C and a heterozygous TREX1 variant p.C99MfsX3 in a family with hereditary small vessel disease of the brain
    Bing Wen Soong
    Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 76:319-24. 2013
    Mutations in the TREX1 and NOTCH3 genes cause retinal vasculopathy with cerebral leukodystrophy (RVCL) and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), respectively...
  19. ncbi The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death
    Dipanjan Chowdhury
    CBR Institute for Biomedical Research, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 23:133-42. 2006
    ..We now find the 3'-to-5' exonuclease TREX1, but not its close homolog TREX2, in the SET complex...
  20. pmc The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease
    Duane A Lehtinen
    Department of Biochemistry, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Biol Chem 283:31649-56. 2008
    Mutations in TREX1 have been linked to a spectrum of human autoimmune diseases including Aicardi-Goutières syndrome (AGS), familial chilblain lupus (FCL), systemic lupus erythematosus, and retinal vasculopathy and cerebral ..
  21. ncbi Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes
    D J Mazur
    Wake Forest University School of Medicine, Department of Biochemistry, Winston Salem, North Carolina 27157, USA
    J Biol Chem 276:14718-27. 2001
    The TREX1 and TREX2 genes encode mammalian 3'-->5' exonucleases. Expression of the TREX genes in human cells was investigated using a reverse transcription-polymerase chain reaction strategy...
  22. doi What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis
    Ana Abad
    Departamento de Inmunologia, Microbiologia y Parasitologia, Facultad de Ciencia y Tecnologia, UPV EHU, Campus de Bizkaia, Leioa, Spain
    Rev Iberoam Micol 27:155-82. 2010
    ..f 17 and afmp2), hydrophobins (rodA/hyp1 and rodB), DHN-melanin, their respective synthases (fks1, rho1-4, ags1-3, chsA-G, och1-4, mnn9, van1, anp1, glfA, pksP/alb1, arp1, arp2, abr1, abr2, and ayg1), and modifying enzymes (..
  23. ncbi Prevalent misconceptions about acute retinal vascular occlusive disorders
    Sohan Singh Hayreh
    Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City, IA 55242 1091, USA
    Prog Retin Eye Res 24:493-519. 2005
    ..cribrosa; (viii) clinical picture of CRVO is often due to compression or strangulation of the central retinal vein (CRV) in the lamina cribrosa and not its occlusion; (ix) an eye can develop both CRVO and central retinal artery ..
  24. ncbi [Pharmacological stress echocardiography for diagnosing of viable myocardium in severe left ventricular dysfunction]
    Wei xian Yang
    Division of Coronary Heart Disease, Cardiovascular Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China
    Zhonghua Nei Ke Za Zhi 44:581-4. 2005
    ..isosorbide dinitrate and their combination in stress echocardiography to predict regional movement recovery after coronary revascularization (CRV) in patients with old myocardial infarction (OMI) and severe left ventricular dysfunction.
  25. pmc Genome of crocodilepox virus
    C L Afonso
    Plum Island Animal Disease Center, United States Department of Agriculture, Greenport, New York, NY 11944, USA
    J Virol 80:4978-91. 2006
    ..genome sequence, with analysis, of a poxvirus infecting Nile crocodiles (Crocodylus niloticus) (crocodilepox virus; CRV)...
  26. doi Cognitive impairment of vascular origin: neuropathology of cognitive impairment of vascular origin
    Isidre Ferrer
    Institut de Neuropatologia, Servei Anatomia Patològica, IDIBELL Hospital Universitari de Bellvitge, 08907 Hospitalet de Llobregat, Spain
    J Neurol Sci 299:139-49. 2010
    ..Other less common causes are hereditary endotheliopathy with retinopathy, neuropathy and strokes (HERNS), cerebro-retinian vasculopathy (CRV), hereditary vascular retinopathy (HVR) (all three linked to 3p21.1-p21...
  27. ncbi Colour Doppler assessment of blood flow in eyes with central retinal vein occlusion
    Z Ozbek
    Department of Ophthalmology, Dokuz Eylul University School of Medicine, Izmir, Turkey
    Ophthalmologica 216:231-4. 2002
    ..To assess the blood flow changes in eyes with central retinal vein occlusion (CRVO) and compare these values with values of fellow eyes and eyes of normal subjects...
  28. ncbi Color doppler imaging of ocular hemodynamic changes in Behçet's disease
    Ihsan Caca
    Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, Turkey
    Jpn J Ophthalmol 48:101-5. 2004
    ..A prospective evaluation of the ocular blood flow velocity in patients with BehCet's disease was carried out to determine its changes...
  29. pmc Do all of the neurologic diseases in patients with DNA repair gene mutations result from the accumulation of DNA damage?
    P J Brooks
    Section on Molecular Neurobiology, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, 5625 Fishers Lane, Room 3S32, Rockville, MD 20852, USA
    DNA Repair (Amst) 7:834-48. 2008
    ..Second, in AGS, which is caused by mutations in either TREX1 or RNASEH2, recent evidence indicates that failure to degrade nucleic acids produced during S-phase triggers ..
  30. ncbi Colour Doppler examination of early and late orbital haemodynamic changes in eyes with eyelid oedema due to blunt trauma
    Mehmet Numan Alp
    Department of Ophthalmology, Numune Training and Research Hospital, Ankara, Turkey
    Acta Ophthalmol Scand 84:242-5. 2006
    ..To evaluate the early and late alterations in orbital blood flow parameters in eyes with severe eyelid swelling due to blunt trauma by using colour Doppler ultrasonography (CDU)...
  31. ncbi Study on variations in price of prescription medicines in Thailand
    Siriporn Burapadaja
    Faculty of Pharmacy, Chiang Mai University, Thailand
    Yakugaku Zasshi 127:515-26. 2007
    ..The price variations of different classes of medicines varied from about 100% to 600%. The mean price and CRV levels (low and high) formed four groups of medicines with different risks of high prices and variations to payers...
  32. doi Effect of milk yield characteristics, breed, and parity on success of the first insemination in Dutch dairy cows
    C Inchaisri
    Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    J Dairy Sci 93:5179-87. 2010
    ..lactations from 1,396 herds obtained from the Dutch dairy cow database of the Cattle Improvement Co-operative (CRV). Cows that had the first insemination (AI) between 40 and 150 d postpartum were selected...
  33. doi Familial chilblain lupus--a monogenic form of cutaneous lupus erythematosus due to a heterozygous mutation in TREX1
    C Gunther
    University Hospital for Dermatology, Technical University Dresden, Dresden, Germany
    Dermatology 219:162-6. 2009
    ..a familial form of chilblain lupus manifesting in early childhood caused by a heterozygous mutation in the TREX1 gene, which encodes a 3'-5' DNA exonuclease...
  34. ncbi Correlation between higher blood flow velocity in the central retinal vein than in the central retinal artery and severity of nonproliferative diabetic retinopathy
    Sayuri Fujioka
    Department of Ophthalmology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Jpn J Ophthalmol 50:312-7. 2006
    To assess the correlation between a higher blood flow velocity in the central retinal vein (CRV) than in the central retinal artery (CRA) and the severity of nonproliferative diabetic retinopathy (non-PDR).
  35. pmc Opposing effects of inhibiting cap addition and cap methylation on polyadenylation during vesicular stomatitis virus mRNA synthesis
    Jianrong Li
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 83:1930-40. 2009
    ..We previously mapped amino acid residues G1154, T1157, H1227, and R1228, present within conserved region V (CRV) of L, as essential for mRNA cap addition...
  36. doi Randomised, cross-over, comparative bioavailability trial of matrix type transdermal drug delivery system (TDDS) of carvedilol and hydrochlorothiazide combination in healthy human volunteers: a pilot study
    Shyam S Agrawal
    Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research DIPSAR, Pushp Vihar, Sector 3, New Delhi 110017, India
    Contemp Clin Trials 31:272-8. 2010
    The present study deals with transdermal drug delivery system (TDDS) of Carvedilol (CRV) and Hydrochlorothiazide (HCTZ)...
  37. ncbi [The change of fractalkine in serum and pulmonary arterioles of hypoxic rat]
    Xiao Ju Chen
    Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 38:756-60. 2007
    ....
  38. ncbi Preliminary definition of disease flare in juvenile rheumatoid arthritis
    Hermine I Brunner
    William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    J Rheumatol 29:1058-64. 2002
    ..To develop preliminary criteria for defining disease flare in patients with polyarticular-course juvenile rheumatoid arthritis (JRA)...
  39. pmc Rhes and AGS1/Dexras1 affect signaling by dopamine D1 receptors through adenylyl cyclase
    Laura M Harrison
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana
    J Neurosci Res 89:874-82. 2011
    The GTP binding proteins Rhes and AGS1/Dexras1 define a subfamily of the Ras superfamily and have been shown to affect signaling by G-protein-coupled receptors...
  40. pmc Two alpha(1-3) glucan synthases with different functions in Aspergillus fumigatus
    A Beauvais
    Aspergillus Unit, Institut Pasteur, Paris, France
    Appl Environ Microbiol 71:1531-8. 2005
    ..Two genes in A. fumigatus, AGS1 and AGS2, are highly homologous to the AGS genes of Schizosaccharomyces pombe, which encode putative alpha(1-3) ..
  41. pmc The early secretory pathway contributes to the growth of the Coxiella-replicative niche
    Emanuel Martín Campoy
    Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia IHEM CONICET, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo, Mendoza, Argentina
    Infect Immun 79:402-13. 2011
    ..We present evidence that Rab1b is recruited to the CRV at later infection times (i.e., after 6 h of infection)...
  42. pmc A small protein (Ags1p) and the Pho80p-Pho85p kinase complex contribute to aminoglycoside antibiotic resistance of the yeast Saccharomyces cerevisiae
    S Wickert
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    J Bacteriol 180:1887-94. 1998
    We identified the AGS1 and AGS3 genes by their ability to partially complement an ags mutant (RC1707) which is supersensitive to various aminoglycoside antibiotics (J. F. Ernst and R. K. Chan, J. Bacteriol. 163:8-14, 1985)...
  43. ncbi Topical latanoprost and optic nerve head and retinal circulation in humans
    Y Tamaki
    Department of Ophthalmology, University of Tokyo School of Medicine, Japan
    J Ocul Pharmacol Ther 17:403-11. 2001
    ..resistive index (RI) in the central retinal artery (CRA) and mean blood velocity (MV) in the central retinal vein (CRV). One drop of 0...
  44. ncbi Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center
    Roy F Chemaly
    Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Medicine (Baltimore) 85:278-87. 2006
    ..049) was associated with development of influenza pneumonia. The overall mortality rate for CRV pneumonia was 15%...
  45. pmc Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer
    Xiaoqun Dong
    Department of Gastrointestinal Medical Oncology, Surgical Oncology, Pathology, and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 27:1592-9. 2009
    ..DNA mismatch repair (MMR) is critical in maintaining genomic stability and may modulate the cellular response to gemcitabine. We hypothesized that genetic variations in MMR may affect the clinical outcome of patients with pancreatic cancer...
  46. doi What can we learn from genetic studies of systemic lupus erythematosus? Implications of genetic heterogeneity among populations in SLE
    H S Lee
    Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea
    Lupus 19:1452-9. 2010
    ..pathways: (i) innate immune response including TLR/interferon signaling pathways (IRF5, STAT4, TNFAIP3, and TREX1); (ii) adaptive immune response (HLA-DR, PTPN22, PDCD1, STAT4, LYN, BLK, and BANK1) including B, T cells, and ..
  47. doi Review: molecular genetics and pathology of hereditary small vessel diseases of the brain
    Y Yamamoto
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Neuropathol Appl Neurobiol 37:94-113. 2011
    ..The RVCL disorders characterized by profound retinopathy are associated with mutations in TREX1, which encodes an abundant 3'-5' DNA-specific exonuclease...
  48. ncbi Yeast Crv4/Ttp1, a predicted type II membrane protein, is involved in an event important for growth, functionally overlapping with the event regulated by calcineurin- and Mpk1-mediated pathways
    T Nakamura
    Department of Molecular Biotechnology, Graduate School of Engineering, Hiroshima University, Japan
    Mol Gen Genet 256:481-7. 1997
    The Saccharomyces cerevisiae crv mutants (crv1, 2, 3 and 4) exhibit phenotypes, such as calcium resistance and vanadate sensitivity, which are apparently similar to those of calcineurin-deficient mutants...
  49. pmc Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis
    Masashi Morita
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom
    Mol Cell Biol 24:6719-27. 2004
    TREX1, originally designated DNase III, was isolated as a major nuclear DNA-specific 3'-->5' exonuclease that is widely distributed in both proliferating and nonproliferating mammalian tissues...
  50. ncbi Effect of topical unoprostone on circulation of human optic nerve head and retina
    Y Tamaki
    Department of Ophthalmology, University of Tokyo School of Medicine, Japan
    J Ocul Pharmacol Ther 17:517-27. 2001
    ..resistive index (RI) in the central retinal artery (CRA) and mean blood velocity (MV) in the central retinal vein (CRV)...
  51. ncbi Role of the synthase domain of Ags1p in cell wall alpha-glucan biosynthesis in fission yeast
    Alina Vos
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Biol Chem 282:18969-79. 2007
    ..mutant Ags1p showed a markedly reduced ability to complement the cell lysis phenotype of the temperature-sensitive ags1-1 mutant. Therefore, we conclude that, in S...
  52. pmc DNA binding induces active site conformational change in the human TREX2 3'-exonuclease
    Udesh de Silva
    Department of Biochemistry, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Nucleic Acids Res 37:2411-7. 2009
    The TREX enzymes process DNA as the major 3'-->5' exonuclease activity in mammalian cells. TREX2 and TREX1 are members of the DnaQ family of exonucleases and utilize a two metal ion catalytic mechanism of hydrolysis...
  53. doi Quantitative vascular pathology and phenotyping familial and sporadic cerebral small vessel diseases
    Lucinda J L Craggs
    Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Brain Pathol 23:547-57. 2013
    ..dementia of Swedish type (Swedish hMID), and hereditary endotheliopathy with retinopathy, nephropathy, and stroke (HERNS)...
  54. pmc Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study
    Gillian I Rice
    Manchester Centre for Genomic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Sciences Centre MAHSC, Manchester, UK
    Lancet Neurol 12:1159-69. 2013
    Aicardi-Goutières syndrome (AGS) is an inflammatory disorder caused by mutations in any of six genes (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR). The disease is severe and effective treatments are urgently needed...
  55. pmc Association of nuclear annexin A1 with prognosis of patients with esophageal squamous cell carcinoma
    Gaohua Han
    Department of Oncology, The Affiliated Second Hospital of Suzhou University Suzhou, Jiangsu, China Department of Oncology, Taizhou People s Hospital Taizhou, Jiangsu, China
    Int J Clin Exp Pathol 7:751-9. 2014
    ..The aim of this study was to evaluate the relationship between the expressions of Annexin A1 (ANXA1), three prime repair exonuclease 1 (TREX1) and apurinic/apyrimidinic endonuclease-1 (APE1) and clinical outcome of patients with ESCC...
  56. doi Impact of Polymorphic Variations of Gemcitabine Metabolism, DNA Damage Repair, and Drug-Resistance Genes on the Effect of High-Dose Chemotherapy for Relapsed or Refractory Lymphoid Malignancies
    Keiji Shinozuka
    Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas
    Biol Blood Marrow Transplant 22:843-9. 2016
    ..and hCNT3; DNA damage repair genes RECQL, X-ray repair complementing 1, RAD54L, ATM, ATR, MLH1, MSH2, MSH3, TREX1, EXO1, and TP73; and multidrug-resistance genes MRP2 and MRP5; as well as glutathione-S-transferase GSTP1 in 153 ..
  57. doi Community acquired respiratory virus infections in cancer patients-Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology
    Marie von Lilienfeld-Toal
    Department of Haematology and Medical Oncology, Jena University Hospital, Jena, Germany Centre for Sepsis Control and Care CSCC, University Hospital Jena, Germany Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institut, Jena, Germany Electronic address
    Eur J Cancer 67:200-212. 2016
    Community acquired viruses (CRVs) may cause severe disease in cancer patients. Thus, efforts should be made to diagnose CRV rapidly and manage CRV infections accordingly.
  58. ncbi Channel catfish reovirus (CRV) inhibits replication of channel catfish herpesvirus (CCV) by two distinct mechanisms: viral interference and induction of an anti-viral factor
    V G Chinchar
    Department of Microbiology, University of Mississippi Medical Center, Jackson 39216, USA
    Dis Aquat Organ 33:77-85. 1998
    Catfish reovirus (CRV), a double stranded RNA virus, inhibited channel catfish herpes-virus (CCV) replication by 2 different mechanisms: (1) directly as a consequence of its own replication, and (2) indirectly due to the induction of an ..
  59. ncbi Conventional respiratory viruses recovered from immunocompromised patients: clinical considerations
    N Rabella
    Servei de Microbiologia, Unitat de Malalties Infeccioses, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    Clin Infect Dis 28:1043-8. 1999
    ..We identified 22 patients from whom a CRV was the only microorganism recovered; 13 patients developed pneumonia, 10 had acute respiratory failure, 5 required ..
  60. pmc Effect of Cr(V) on reproductive organ morphology and sperm parameters: an experimental study in mice
    Maria de Lourdes Pereira
    Department of Biology, University of Aveiro, 3810 193, Aveiro, Portugal
    Environ Health 4:9. 2005
    ..In this study, the acute toxicity of a physiologically stable Cr(V) compound, [CrV-BT](2-) (BT = bis(hydroxyethyl)aminotris(hydroxymethyl)methane) was investigated in the male reproductive system of ..
  61. ncbi [Value of color doppler imaging in the diagnosis of occlusive retinal venous lesions]
    T N Kiseleva
    Vestn Oftalmol 122:4-7. 2006
    ..Occlusion of the central retinal vein (CRV) was observed in 82 (65.6%) patients and that of CRV branches was seen in 43 (34.4%) patients...
  62. ncbi Orbital color Doppler imaging in Behçet's disease with or without ocular involvement
    Cuneyt Isik
    Department of Ophthalmology, Pamukkale University School of Medicine, PK 66, Denizli 20100, Turkey
    Int Ophthalmol 27:37-42. 2007
    ..To investigate the value of color Doppler imaging (CDI) of orbital vasculature in the assessment of ocular involvement in patients with Behçet's disease (BD) without clinical ophthalmologic abnormalities...
  63. pmc Clinical and molecular phenotype of Aicardi-Goutieres syndrome
    Gillian Rice
    Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, LS9 7TF, UK
    Am J Hum Genet 81:713-25. 2007
    ..AGS exhibits locus heterogeneity, with mutations identified in genes encoding the 3'-->5' exonuclease TREX1 and the three subunits of the RNASEH2 endonuclease complex...
  64. ncbi [Cardiac rhythm variability during active orthostatic test in patients with arterial hypertension]
    L I Gapon
    Klin Med (Mosk) 86:35-8. 2008
    The aim of the study was to evaluate cardiac rhythm variability (CRV) during active orthostatic test (AOT) in patients with arterial hypertension (AH) living in Tyumen near-Ob region...
  65. doi Genetics of migraine: an update with special attention to genetic comorbidity
    Anine H Stam
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Curr Opin Neurol 21:288-93. 2008
    ..Special attention will be given to comorbid diseases of migraine...
  66. doi Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease
    Tomas Lindahl
    Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms, Herts, UK
    Biochem Soc Trans 37:535-8. 2009
    The major DNA-specific 3'-5' exonuclease of mammalian cells is TREX1 (3' repair exonuclease 1; previously called DNase III). The human enzyme is encoded by a single exon and, like many 3' exonucleases, exists as a homodimer...
  67. doi A de novo p.Asp18Asn mutation in TREX1 in a patient with Aicardi-Goutières syndrome
    Charlotte A Haaxma
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Med Genet A 152:2612-7. 2010
    ..Mutations in the TREX1 gene are found in approximately 25% of patients...
  68. pmc Laboratory diagnosis, epidemiology, and clinical outcomes of pandemic influenza A and community respiratory viral infections in southern Brazil
    Sonia M Raboni
    Carlos Chagas Institute, Fiocruz Paraná, Curitiba, Parana, Brazil
    J Clin Microbiol 49:1287-93. 2011
    ..For the FLUA H1N1v- and CRV-infected patients, epidemiological data regarding median age (30 and 1...
  69. pmc Surface α-1,3-glucan facilitates fungal stealth infection by interfering with innate immunity in plants
    Takashi Fujikawa
    National Institute of Agrobiological Sciences NIAS, Tsukuba, Ibaraki, Japan
    PLoS Pathog 8:e1002882. 2012
    ..oryzae, C. miyabeanus and R. solani as well as in non-transgenic rice inoculated with the ags1 mutant...
  70. pmc Molecular basis of DNA recognition in the immune system
    Maninjay K Atianand
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 190:1911-8. 2013
    ..In addition, if nucleases, such as DNase II or DNase III (Trex1), fail to clear self-DNA, accumulated DNA gains access to intracellular compartments where it drives ..
  71. doi Evaluation of different microtiter plate-based methods for the quantitative assessment of Staphylococcus aureus biofilms
    Walid F Elkhatib
    Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
    Future Microbiol 9:725-35. 2014
    ..To quantitatively assess Staphylococcus aureus biofilms...
  72. doi Genome-wide analysis of 5-hmC in the peripheral blood of systemic lupus erythematosus patients using an hMeDIP-chip
    Weiguo Sui
    Guangxi Key Laboratory of Metabolic Diseases Research, Central Laboratory of Guilin 181st Hospital, Guilin, Guangxi 541002, P R China
    Int J Mol Med 35:1467-79. 2015
    ..Out of the differentially hydroxymethylated genes, three were selected for validation, including TREX1, CDKN1A and CDKN1B. The hydroxymethylation levels of the three genes were confirmed by RT-qPCR...
  73. pmc Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome
    Elizabeth E Gray
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195
    J Immunol 195:1939-43. 2015
    ..However, chronic activation of this pathway is implicated in autoimmunity. Mutations in TREX1, a 3' repair exonuclease that degrades cytosolic DNA, cause Aicardi-Goutières syndrome and chilblain lupus...
  74. doi Incidence and predictors of respiratory viral infections by multiplex PCR in allogeneic hematopoietic cell transplant recipients 50 years and older including geriatric assessment
    Christopher R D'Angelo
    a Department of Medicine, University of Chicago
    Leuk Lymphoma 57:1807-13. 2016
    Community respiratory viruses (CRV) are important agents of morbidity and mortality within the allogeneic hematopoietic stem cell transplant (HCT) population. Few proven methods to prevent CRV infections exist...
  75. pmc RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA
    Christine Wolf
    Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden, 01307 Dresden, Germany
    Nat Commun 7:11752. 2016
    ..Mutations in the exonuclease TREX1 cause type I IFN-dependent autoinflammation and autoimmunity...
  76. ncbi Clinical and neuroradiologic variability of Aicardi-Goutiéres syndrome: Two siblings with RNASEH2C mutation and a boy with TREX1 mutation
    Emek Uyur Yalçın
    Division of Child Neurology, Department of Pediatrics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey
    Turk J Pediatr 57:504-8. 2015
    ..three AGS cases with different clinical presentation, two male siblings with RNASEH2C mutation and a boy with TREX1 mutation...
  77. doi Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity
    Katrin Peschke
    Institute for Immunology, Faculty of Medicine Carl Gustav Carus, University of Technology, 01307 Dresden, Germany
    J Immunol 197:2157-66. 2016
    Defects of the intracellular enzyme 3' repair exonuclease 1 (Trex1) cause the rare autoimmune condition Aicardi-Goutières syndrome and are associated with systemic lupus erythematosus...
  78. pmc Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations
    Anine H Stam
    1 Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Brain . 2016
    ..Recently they were shown to be one disease caused by C-terminal frame-shift mutations in TREX1, which was termed 'retinal vasculopathy with cerebral leukodystrophy'...
  79. doi A nationwide survey of Aicardi-Goutières syndrome patients identifies a strong association between dominant TREX1 mutations and chilblain lesions: Japanese cohort study
    Junya Abe
    Department of Pediatrics, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Rheumatology (Oxford) 53:448-58. 2014
    ..Here we performed a nationwide survey of AGS patients in Japan and analysed the genetic and clinical data...
  80. doi Redox and complexation chemistry of the CrVI/CrV-D-glucaric acid system
    María Florencia Mangiameli
    Área Química General, Departamento de Químico Física, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, UNR, Instituto de Química de Rosario CONICET, Suipacha 531, S2002LRK, Rosario, Santa Fe, Argentina
    Dalton Trans 43:9242-54. 2014
    ..In vitro, our studies on the chemistry of oxo-Cr(V)-Glucar complexes can provide information on the nature of the species that are likely to be stabilized in vivo...
  81. doi The Cliff Reconnaissance Vehicle: a tool to improve astronaut exploration efficiency
    Alain Souchier
    Association Planète Mars, Vernon, France
    Astrobiology 14:406-16. 2014
    ..The latest tests in the series in which the Cliff Reconnaissance Vehicle (CRV) or Cliffbot was used were conducted as part of the Austrian Space Forum's MARS2013 field analog project in Morocco ..
  82. ncbi Time-cycled inverse ratio ventilation does not improve gas exchange during anaesthesia
    W A Tweed
    Department of Anaesthesia, National University Hospital, National University of Singapore
    Can J Anaesth 38:311-7. 1991
    ..Conventional ratio ventilation (CRV) and IRV were compared in 24 low-risk surgical patients who were paralysed and whose lungs were ventilated with air/..
  83. ncbi Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling
    M J Cismowski
    Cadus Pharmaceutical Corporation, 777 Old Saw Mill River Road, Tarrytown 10591, NY, USA
    Nat Biotechnol 17:878-83. 1999
    ..One of the cDNAs identified from the activator screen, a human Ras-related G protein that we term AGS1 (for activator of G-protein signaling), appears to function by facilitating guanosine triphosphate (GTP) exchange ..
  84. ncbi Non-oxidative mechanisms are responsible for the induction of mutagenesis by reduction of Cr(VI) with cysteine: role of ternary DNA adducts in Cr(III)-dependent mutagenesis
    A Zhitkovich
    Brown University, Department of Pathology and Laboratory Medicine, Providence, Rhode Island 02912, USA
    Biochemistry 40:549-60. 2001
    ..Although intermediate reaction products (CrV/IV, thiyl radicals) were capable of oxidizing DCFH, they were insufficiently reactive to damage DNA...
  85. ncbi Accessory proteins for G protein-signaling systems: activators of G protein signaling and other nonreceptor proteins influencing the activation state of G proteins
    Joe B Blumer
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70118, USA
    Receptors Channels 9:195-204. 2003
    ..Activators of G protein signaling (AGS1-3) refer to a functionally defined group of proteins that activate G protein-signaling systems in the absence of a ..
  86. ncbi Changes in cerebral and ocular hemodynamics in Behçet's disease assessed by color-coded duplex sonography
    Sevda Yilmaz
    Department of Radiology, School of Medicine, University of Kirikkale, Kirikkale, Turkey
    Eur J Radiol 58:102-9. 2006
    ..To quantify the cerebral and retrobulbar hemodynamics in Behçet's disease with and without ocular involvement and compared with that of healthy controls...
  87. ncbi Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California 91766 1854, USA
    Biochemistry 45:2014-26. 2006
    We investigated the molecular mechanisms and the binding site location for the fluorophor crystal violet (CrV), a noncompetitive antagonist of the nicotinic acetylcholine receptor (AChR)...
  88. ncbi Protection of mice from rabies by intranasal immunization with inactivated rabies virus
    Atsushi Yoneda
    Department of Global Animal Resource Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Exp Anim 57:1-9. 2008
    ..Mice were intranasally administered five times with inactivated and concentrated rabies virus antigen (CRV) supplemented with or without cholera toxin (CT)...
  89. pmc Transcriptional analysis of the mammalian heart with special reference to its endocrine function
    Monica Forero McGrath
    Department of Cellular Molecular Medicine, Faculty of Medicine, Cardiovascular Endocrinology Laboratory, University of Ottawa Heart Institute, Ottawa, Canada
    BMC Genomics 10:254. 2009
    ..We postulated that comparison of gene expression profiles between atrial and ventricular muscles would help identify gene transcripts that underlie the phenotypic differences associated with the endocrine function of the heart...
  90. ncbi Conversion from nonischemic to ischemic retinal vein occlusion: prediction by venous velocity on color Doppler imaging
    Sophie Arsene
    CHRU de Tours, Service d Ophtalmologie, Tours France
    Eur J Ophthalmol 19:1009-16. 2009
    ..To identify color Doppler imaging (CDI) parameters and other prognostic factors of a conversion from nonischemic to ischemic retinal vein occlusion (RVO) in a large population with a long follow-up...
  91. pmc The yeast-phase virulence requirement for α-glucan synthase differs among Histoplasma capsulatum chemotypes
    Jessica A Edwards
    Department of Microbiology, Center for Microbial Interface Biology, Ohio State University, 484 W 12th Avenue, Columbus, Ohio 43210, USA
    Eukaryot Cell 10:87-97. 2011
    ..Analysis of the chemotype I α-glucan synthase (AGS1) locus revealed a 2.7-kb insertion in the promoter region that diminishes AGS1 expression...
  92. ncbi 193 bovine embryo genotyping using a 50k single nucleotide polymorphism chip
    A D Le Bourhis
    UNCEIA, R and D, Maisons Alfort, 94704, France
    Reprod Fertil Dev 23:197. 2011
    ..Following WGA, DNA concentration was determined by using PicoGreen. For subsequent genotyping, a custom CRV 50K Illumina chip was used. Call rates were calculated from 50905 SNP...
  93. ncbi [Cadasil and other hereditary small vessel diseases of the brain--increasingly diagnosed conditions underlying familial ischaemic stroke and dementia]
    Bence Gunda
    Centre de référence des maladies vasculaires rares du cerveau et de l oeil, Service de Neurologie, Hopital Lariboisiere, Universite Paris VII, Párizs, Franciaország
    Ideggyogy Sz 64:88-100. 2011
    ..we have far less knowledge on other forms of hereditary small vessel disease of the brain such as CARASIL, HERNS, CRV, HVR, PXE etc...
  94. doi In vivo evaluation of alginate microspheres of carvedilol for nasal delivery
    Sanjay B Patil
    Shri Neminath Jain Brahmacharyashram s Shriman Sureshdada Jain College of Pharmacy, Nashik, Maharashtra, India
    J Biomed Mater Res B Appl Biomater 100:249-55. 2012
    Mucoadhesive alginate microspheres of carvedilol (CRV) for nasal administration intended to avoid first pass metabolism and to improve bioavailability were prepared and evaluated...
  95. pmc Fission yeast Ags1 confers the essential septum strength needed for safe gradual cell abscission
    Juan Carlos G Cortés
    Instituto de Biología Funcional y Genómica, Consejo Superior de Investigaciones Científicas CSIC Universidad de Salamanca, 37007 Salamanca, Spain
    J Cell Biol 198:637-56. 2012
    ..its localization and function in the cell wall or about cooperation between the α- and β(1-3)glucan synthases Ags1 and Bgs for cell wall and septum assembly...
  96. pmc My journey to DNA repair
    Tomas Lindahl
    Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, United Kingdom
    Genomics Proteomics Bioinformatics 11:2-7. 2013
    ..I discovered the mammalian exonucleases DNase III (TREX1) and IV (FEN1). Interestingly, expression of TREX1 was altered in some human autoimmune diseases...
  97. pmc Pre-clinical toxicity & immunobiological evaluation of DNA rabies vaccine & combination rabies vaccine in rhesus monkeys (Macaca mulatta)
    B Dinesh Kumar
    National Institute of Nutrition ICMR, Hyderabad, India
    Indian J Med Res 137:1072-88. 2013
    ..first indigenously developed recombinant DNA anti-rabies vaccine [DRV (100 μg)] and combination rabies vaccine [CRV (100 μg DRV and 1...
  98. doi A poly(A)-specific ribonuclease directly regulates the poly(A) status of mitochondrial mRNA in Arabidopsis
    Takashi Hirayama
    Institute of Plant Science and Resources, Okayama University, 2 20 1 Chuo, Kurashiki, Okayama 710 0046, Japan
    Nat Commun 4:2247. 2013
    ..directly regulates the poly(A) tract of mitochondrial mRNA in conjunction with a bacterial-type poly(A) polymerase, AGS1, in Arabidopsis...

Research Grants22

  1. Understanding the role of TREX1 in the innate immunity and autoimmune diseases
    Nan Yan; Fiscal Year: 2012
    ..This application seeks to understand the role of TREX1 in the innate immunity and autoimmune diseases...
  2. Granzyme a Pathway of CTL-Mediated Cell Death
    Judy Lieberman; Fiscal Year: 2010
    ..activated endogenously by ischemia and seizures in the brain and that mutations in the granzyme A-activated DNase TREX1 that render cells resistant to granzyme A are genetically linked to inflammatory neurological diseases and ..
  3. Judy Lieberman; Fiscal Year: 2016
    ..HIV evasion of these sensors is mediated by the Trex1 DNase, which digests failed reverse transcripts...
  4. Mechanisms of the 3'-->5'deoxyribonucleases
    Fred W Perrino; Fiscal Year: 2012
    ..In the previous funding period we determined the structures of the TREX1 and TREX2 enzymes allowing us to begin to describe the biochemical properties of these 3'deoxyribonucleases...
  5. Daniel B Stetson; Fiscal Year: 2016
    ..We then identified 3'repair exonuclease 1 (Trex1) as a cytosolic, ISD-binding DNA exonuclease...
  6. Nan Yan; Fiscal Year: 2016
    ..We recently discovered that the cytosolic exonuclease TREX1 suppressed the IFN response triggered by HIV DNA...
  7. Pathobiology of Retinal Vasculopathy with Cerebal Leukodystrophy (RVCL)
    Joanna C Jen; Fiscal Year: 2010
    ..A collaborative effort led to the recent discovery of heterozygous carboxyl-terminal frameshift mutations in TREX1, a 3'-5'DNA exonuclease...
  8. MATTHIAS R WABL; Fiscal Year: 2014
    ..have three lines of evidence for our hypothesis that retroelements can mediate autoimmune disease: (i) The enzyme Trex1 degrades retroelements, and Trex1-deficient patients and mice suffer from autoimmune disease...
  9. Improving Animal Resources at the University of Georgia
    CHRISTOPHER SIMON KING; Fiscal Year: 2012
    ..Coverdell Center for Biomedical &Health Sciences. The Coverdell Rodent Vivarium (CRV) is a large state-of-the-art barrier facility that if properly equipped can replace aged, dispersed and haphazardly ..
  10. AGS4 in G-protein Signal Processing
    Joe B Blumer; Fiscal Year: 2013
    ..Furthermore, they provide unexpected targets for development of therapeutics for diseases which result from altered heterotrimeric G-protein signaling. ..
  11. MINIATURE ELECTROHYDRAULIC TOTAL ARTIFICIAL HEART
    FRED ZARINETCHI; Fiscal Year: 1999
    ..The proposed device modifies our existing electrohydraulic TAH by using a continuously rotating valve (CRV) to shuttle hydraulic fluid between left and right blood pump actuation...
  12. AGS1 and signal processing by G-proteins
    STEPHEN LANIER; Fiscal Year: 2009
    ..This proposal focuses on AGS1, which is unique among the AGS family members...
  13. Tumor Suppressors in Lymphocytes
    Matthias Wabl; Fiscal Year: 2008
    ..Subsequently, a subset of them will be further characterized and the nature of their cooperation with other oncogenes (co-mutations) will be determined. ..
  14. Mucosal and Peripheral NK-T Cells in HIV Infection
    Otto Yang; Fiscal Year: 2007
    ..Exploring NK-T cells in HIV-1 infection could there have a high impact on the development of new strategies in prevention and treatment. [unreadable] [unreadable]..
  15. Granzyme a Pathway of CTL-Mediated Cell Death
    Judy Lieberman; Fiscal Year: 2008
    ..abstract_text> ..
  16. Sensitivity Mechanisms in Chromium Toxicity
    Anatoly Zhitkovich; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. Immune evasion by KSHV
    Laurent Coscoy; Fiscal Year: 2008
    ..An important step in our understanding of MIR1 functions will be to identify its cellular cofactors (specific aim 2). ..
  18. Physical Activity Measurement in Older Adults
    Lisa Colbert; Fiscal Year: 2007
    ..This methodology can then be incorporated into future studies examining the associations between doses of physical activity and various health outcomes. [unreadable] [unreadable]..
  19. Metal Carcinogenesis: New Concepts
    Anatoly Zhitkovich; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  20. GLOMERULAR PERMSELECTIVITY IN ALPORT SYNDROME
    Clifford Kashtan; Fiscal Year: 2004
    ..This trial will compare urinary protein levels, kidney function, and renal structural changes in treated and untreated dogs. ..