TREX1

Summary

Gene Symbol: TREX1
Description: three prime repair exonuclease 1
Alias: AGS1, CRV, DRN3, HERNS, three-prime repair exonuclease 1, 3' repair exonuclease 1, 3'-5' exonuclease TREX1, DNase III, deoxyribonuclease III
Species: human
Products:     TREX1

Top Publications

  1. Crow Y, Hayward B, Parmar R, Robins P, Leitch A, Ali M, et al. Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus. Nat Genet. 2006;38:917-20 pubmed
    ..Here, we show that TREX1, encoding the major mammalian 3' --> 5' DNA exonuclease, is the AGS1 gene, and AGS-causing mutations result in ..
  2. Mazur D, Perrino F. Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins. J Biol Chem. 2001;276:17022-9 pubmed
    ..The mammalian TREX1 and TREX2 proteins contain potent 3'-->5' exonucleases capable of functioning in this capacity...
  3. Chowdhury D, Beresford P, Zhu P, Zhang D, Sung J, Demple B, et al. The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Mol Cell. 2006;23:133-42 pubmed
    ..We now find the 3'-to-5' exonuclease TREX1, but not its close homolog TREX2, in the SET complex...
  4. Rice G, Newman W, Dean J, Patrick T, Parmar R, Flintoff K, et al. Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome. Am J Hum Genet. 2007;80:811-5 pubmed
    b>TREX1 constitutes the major 3'-->5' DNA exonuclease activity measured in mammalian cells. Recently, biallelic mutations in TREX1 have been shown to cause Aicardi-Goutieres syndrome at the AGS1 locus...
  5. Richards A, van den Maagdenberg A, Jen J, Kavanagh D, Bertram P, Spitzer D, et al. C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy. Nat Genet. 2007;39:1068-70 pubmed
    ..In nine families, we identified heterozygous C-terminal frameshift mutations in TREX1, which encodes a 3'-5' exonuclease...
  6. Yang Y, Lindahl T, Barnes D. Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell. 2007;131:873-86 pubmed
    b>Trex1 is the major 3' DNA exonuclease in mammalian cells, and mutations in the human TREX1 gene can cause Aicardi-Goutières syndrome, characterized by perturbed immunity...
  7. Stetson D, Ko J, Heidmann T, Medzhitov R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell. 2008;134:587-98 pubmed publisher
    ..In a screen for proteins relevant to this IFN-stimulatory DNA (ISD) response, we identify 3' repair exonuclease 1 (Trex1)...
  8. Namjou B, Kothari P, Kelly J, Glenn S, Ojwang J, Adler A, et al. Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort. Genes Immun. 2011;12:270-9 pubmed publisher
    ..Rare mutations in the TREX1 gene, the major mammalian 3'-5' exonuclease, have been reported in sporadic SLE cases...
  9. Hoss M, Robins P, Naven T, Pappin D, Sgouros J, Lindahl T. A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein. EMBO J. 1999;18:3868-75 pubmed
    ..2-21.3. In a reconstituted human DNA repair system containing DNA polymerase beta and DNA ligase III-XRCC1, accurate rejoining of a 3' mismatched base residue at a single-strand break is dependent on addition of the exonuclease. ..

More Information

Publications122 found, 100 shown here

  1. de Silva U, Choudhury S, Bailey S, Harvey S, Perrino F, Hollis T. The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering. J Biol Chem. 2007;282:10537-43 pubmed
    The TREX1 enzyme processes DNA ends as the major 3' --> 5' exonuclease activity in human cells...
  2. Christmann M, Tomicic M, Aasland D, Berdelle N, Kaina B. Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage. Nucleic Acids Res. 2010;38:6418-32 pubmed publisher
    ..The experiments revealed a clear up-regulation of the three prime exonuclease I (trex1) mRNA following ultraviolet (UV) light treatment...
  3. Mazur D, Perrino F. Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. J Biol Chem. 1999;274:19655-60 pubmed
    ..We have identified the cDNA sequences encoding two 3'-->5' exonucleases (TREX1 and TREX2) from mammalian cells. The TREX1 and TREX2 proteins are 304 and 236 amino acids in length, respectively...
  4. Mazur D, Perrino F. Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes. J Biol Chem. 2001;276:14718-27 pubmed
    The TREX1 and TREX2 genes encode mammalian 3'-->5' exonucleases. Expression of the TREX genes in human cells was investigated using a reverse transcription-polymerase chain reaction strategy...
  5. Lee Kirsch M, Chowdhury D, Harvey S, Gong M, Senenko L, Engel K, et al. A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus. J Mol Med (Berl). 2007;85:531-7 pubmed
    ..In this study, we report the identification of a heterozygous missense mutation (D18N) in TREX1 encoding the 3'-5'repair exonuclease 1 in affected individuals of the family with chilblain lupus...
  6. Wang C, Lam W, Bussom S, Chang H, Cheng Y. TREX1 acts in degrading damaged DNA from drug-treated tumor cells. DNA Repair (Amst). 2009;8:1179-89 pubmed publisher
    The major mammalian exonuclease TREX1 has been proposed to play a role in DNA repair and drug resistance. However, no cellular evidence substantiates this claim. Recent reports indicate TREX1's involvement in autoimmunity...
  7. Lee Kirsch M, Gong M, Chowdhury D, Senenko L, Engel K, Lee Y, et al. Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet. 2007;39:1065-7 pubmed
    b>TREX1 acts in concert with the SET complex in granzyme A-mediated apoptosis, and mutations in TREX1 cause Aicardi-Goutières syndrome and familial chilblain lupus...
  8. Soong B, Liao Y, Tu P, Tsai P, Lee I, Chung C, et al. A homozygous NOTCH3 mutation p.R544C and a heterozygous TREX1 variant p.C99MfsX3 in a family with hereditary small vessel disease of the brain. J Chin Med Assoc. 2013;76:319-24 pubmed publisher
    Mutations in the TREX1 and NOTCH3 genes cause retinal vasculopathy with cerebral leukodystrophy (RVCL) and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), respectively...
  9. Lehtinen D, Harvey S, Mulcahy M, Hollis T, Perrino F. The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease. J Biol Chem. 2008;283:31649-56 pubmed publisher
    Mutations in TREX1 have been linked to a spectrum of human autoimmune diseases including Aicardi-Goutières syndrome (AGS), familial chilblain lupus (FCL), systemic lupus erythematosus, and retinal vasculopathy and cerebral ..
  10. Yan N, Cherepanov P, Daigle J, Engelman A, Lieberman J. The SET complex acts as a barrier to autointegration of HIV-1. PLoS Pathog. 2009;5:e1000327 pubmed publisher
    ..reticulum-associated complex that contains 3 DNases (the base excision repair endonuclease APE1, 5'-3' exonuclease TREX1, and endonuclease NM23-H1), inhibits HIV-1 and HIV-2/SIV, but not MLV or ASV, infection...
  11. Scholtissek B, Zahn S, Maier J, Klaeschen S, Braegelmann C, Hoelzel M, et al. Immunostimulatory Endogenous Nucleic Acids Drive the Lesional Inflammation in Cutaneous Lupus Erythematosus. J Invest Dermatol. 2017;137:1484-1492 pubmed publisher
    ..of endogenous nucleic acids and induces CLE-like skin lesions in knockout mice lacking the cytosolic DNase TREX1. Our results provide evidence for a pathogenetic role of endogenous nucleic acids in CLE...
  12. Raynowska J, Miskin D, Pramanik B, Asiry S, Anderson T, Boockvar J, et al. Retinal vasculopathy with cerebral leukoencephalopathy (RVCL): A rare mimic of tumefactive MS. Neurology. 2018;91:e1423-e1428 pubmed publisher
    ..link, RVCL was suspected, and genetic analysis confirmed the diagnosis with a 3-prime repair exonuclease 1 (TREX1) C-terminal mutation...
  13. Asada K, Ito K, Yui D, Tagaya H, Yokota T. Cytosolic Genomic DNA functions as a Natural Antisense. Sci Rep. 2018;8:8551 pubmed publisher
    ..expression using strand selection and knockdown of DNA/RNA hybrid R-loop removing enzyme RNase H and three prime repair exonuclease 1 TREX1 increased the expression levels of cg721 and thus, inhibited the target Naa40 transcript, as ..
  14. Steinhagen F, Zillinger T, Peukert K, Fox M, Thudium M, Barchet W, et al. Suppressive oligodeoxynucleotides containing TTAGGG motifs Inhibit cGAS activation in human monocytes. Eur J Immunol. 2017;: pubmed publisher
    ..In addition, A151 abrogated cGAS activation in response to endogenous accumulation of DNA using TREX1-deficient monocytes. We demonstrate that A151 prevents cGAS activation in a manner that is competitive with DNA...
  15. Liao S, Tammaro M, Yan H. Enriching CRISPR-Cas9 targeted cells by co-targeting the HPRT gene. Nucleic Acids Res. 2015;43:e134 pubmed publisher
    ..Alterations of many genes, such as AAVS1, Exo1 and Trex1, are highly enriched in the 6-TG resistant cells...
  16. Gray E, Winship D, Snyder J, Child S, Geballe A, Stetson D. The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA. Immunity. 2016;45:255-66 pubmed publisher
    ..We also found that ALRs do not contribute to autoimmune disease in the Trex1(-/-) mouse model of Aicardi-Goutières Syndrome...
  17. Marchesi V. Gain-of-function somatic mutations contribute to inflammation and blood vessel damage that lead to Alzheimer dementia: a hypothesis. FASEB J. 2016;30:503-6 pubmed publisher
    ..Because heritable autosomal dominant mutations of NLRP3, APP, TREX1, NOTCH3, and Col4A1 are known to provoke inflammatory reactions and damage the brain in a wide variety of diseases,..
  18. Cisneros G, Perera L, Schaaper R, Pedersen L, London R, Pedersen L, et al. Reaction mechanism of the epsilon subunit of E. coli DNA polymerase III: insights into active site metal coordination and catalytically significant residues. J Am Chem Soc. 2009;131:1550-6 pubmed publisher
    ..Some of these residues were found to be structurally conserved on human TREX1, the exonuclease domains from E. coli DNA-Pol I, and the DNA polymerase of bacteriophage RB69.
  19. Coquel F, Neumayer C, Lin Y, Pasero P. SAMHD1 and the innate immune response to cytosolic DNA during DNA replication. Curr Opin Immunol. 2018;56:24-30 pubmed publisher
    ..but recent studies on factors mutated in the Aicardi-Goutières syndrome cells, such as SAMHD1, RNase H2 and TREX1, are shedding new light on this key process...
  20. Costa Reis P, Sullivan K. Monogenic lupus: it's all new!. Curr Opin Immunol. 2017;49:87-95 pubmed publisher
    ..These include forms that affect nucleic acid repair, degradation and sensing (TREX1, DNASE1L3), the type I interferon (IFN) pathway (SAMHD1, RNASEH2ABC, ADAR1, IFIH1, ISG15, ACP5, TMEM173) and B ..
  21. Cessna J, Fitzgerald R, Zimmerman B, Laureano Pérez L, Bergeron D, van Wyngaardt F, et al. Results of an international comparison of activity measurements of 68Ge. Appl Radiat Isot. 2018;134:385-390 pubmed publisher
    ..Evaluation using the Power-Moderated Mean method results in a proposed Comparison Reference Value (CRV) of 621.7(11)kBqg-1, based on 14 results...
  22. Thirumavalavan N, Hoover C, Gross M. Surgeons Corner: Cavernoscopy for Rear Tip Extender Removal. J Sex Med. 2018;15:1195-1197 pubmed publisher
    ..Thirumavalavan N, Hoover CRV, Gross MS. Surgeons Corner: Cavernoscopy for Rear Tip Extender Removal. J Sex Med 2018;15:1195-1197.
  23. Nagiel A, Lalane R, Jen J, Kreiger A. SUPERFICIAL AND DEEP CAPILLARY ISCHEMIA AS A PRESENTING SIGN OF RETINAL VASCULOPATHY WITH CEREBRAL LEUKOENCEPHALOPATHY AND SYSTEMIC MANIFESTATIONS. Retin Cases Brief Rep. 2017;: pubmed publisher
    ..with cerebral leukoencephalopathy and systemic manifestations, a rare autosomal dominant condition caused by mutations in the TREX1 gene, and to explore the potential efficacy of bevacizumab in preventing capillary occlusions.
  24. Sakai T, Miyazaki T, Shin D, Kim Y, Qi C, Fariss R, et al. DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice. J Autoimmun. 2017;81:13-23 pubmed publisher
    TREX1/DNASE III, the most abundant 3'-5' DNA exonuclease in mammalian cells, is tail-anchored on the endoplasmic reticulum (ER)...
  25. Fabiani C, Murray A, Corradi J, Antollini S. A novel pharmacological activity of caffeine in the cholinergic system. Neuropharmacology. 2018;135:464-473 pubmed publisher
    ..Fluorescent measurements were performed with the conformational sensitive probe crystal violet (CrV) and AChR rich membranes from Torpedo californica...
  26. van Montfoort N, Olagnier D, Hiscott J. Unmasking immune sensing of retroviruses: interplay between innate sensors and host effectors. Cytokine Growth Factor Rev. 2014;25:657-68 pubmed publisher
    ..Host restriction factors such as SAMHD1 and Trex1 play important roles in regulating innate immune sensing, and have led to the idea that innate immune defense and ..
  27. Adang L, Frank D, Gilani A, Takanohashi A, Ulrick N, Collins A, et al. Aicardi goutières syndrome is associated with pulmonary hypertension. Mol Genet Metab. 2018;: pubmed publisher
    ..to be affected by PH: three with pathogenic gain-of-function mutations in the IFIH1 gene and one with heterozygous TREX1 mutations. All studied individuals with AGS were noted to have elevated IFN signature scores (Mann-Whitney p?<?...
  28. Ahn J, Ruiz P, Barber G. Intrinsic self-DNA triggers inflammatory disease dependent on STING. J Immunol. 2014;193:4634-42 pubmed publisher
    ..lupus erythematosus are generally lethal disorders that have been traced to defects in the exonuclease TREX1 (DNase III)...
  29. Buers I, Rice G, Crow Y, Rutsch F. MDA5-Associated Neuroinflammation and the Singleton-Merten Syndrome: Two Faces of the Same Type I Interferonopathy Spectrum. J Interferon Cytokine Res. 2017;37:214-219 pubmed publisher
    ..mutations in 6 different genes were described to be associated with Aicardi-Goutières syndrome, specifically-TREX1, RNASEH2A, RNASEH2B, RNASEH2C, ADAR, and SAMHD1...
  30. König N, Fiehn C, Wolf C, Schuster M, Cura Costa E, Tüngler V, et al. Familial chilblain lupus due to a gain-of-function mutation in STING. Ann Rheum Dis. 2017;76:468-472 pubmed publisher
    ..lupus is a monogenic form of cutaneous lupus erythematosus caused by loss-of-function mutations in the nucleases TREX1 or SAMHD1...
  31. Lim Y, Sanz L, Xu X, Hartono S, Chédin F. Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome. elife. 2015;4: pubmed publisher
    ..of incompletely metabolized endogenous nucleic acid species owing to mutations in nucleic acid-degrading enzymes TREX1 (AGS1), RNase H2 (AGS2, 3 and 4), and SAMHD1 (AGS5)...
  32. Brucher N, Vial J, Baunin C, Labarre D, Meyrignac O, Juricic M, et al. Non-contrast-enhanced MR angiography using time-spin labelling inversion pulse technique for detecting crossing renal vessels in children with symptomatic ureteropelvic junction obstruction: comparison with surgical findings. Eur Radiol. 2016;26:2697-704 pubmed publisher
    ..NC-MRA demonstrated CRVs at the level of the obstruction in 10 children and no CRV in 9 children. All were confirmed intra-operatively except in one of the nine children...
  33. Lo M. Monogenic Lupus. Curr Rheumatol Rep. 2016;18:71 pubmed publisher
    ..Examples include genes important for DNA damage repair (e.g., TREX1), nucleic acid sensing and type I interferon overproduction (e.g...
  34. Grieves J, Fye J, Harvey S, Grayson J, Hollis T, Perrino F. Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. Proc Natl Acad Sci U S A. 2015;112:5117-22 pubmed publisher
    The TREX1 gene encodes a potent DNA exonuclease, and mutations in TREX1 cause a spectrum of lupus-like autoimmune diseases...
  35. Kim H, Noh J, Roh J, Chun D, Kim S, Jung S, et al. Perpendicular Magnetic Anisotropy in FePt Patterned Media Employing a CrV Seed Layer. Nanoscale Res Lett. 2011;6:13 pubmed publisher
    A thin FePt film was deposited onto a CrV seed layer at 400°C and showed a high coercivity (~3,400 Oe) and high magnetization (900-1,000 emu/cm(3)) characteristic of L 10 phase...
  36. Komaki R, Ueda T, Tsuji Y, Miyawaki T, Kusuhara S, Hara S, et al. [Retinal vasculopathy with cerebral leukoencephalopathy carrying TREX1 mutation diagnosed by the intracranial calcification: a case report]. Rinsho Shinkeigaku. 2018;58:111-117 pubmed publisher
    ..thrombotic microangiopathy, Gene analysis demonstrated a causative mutation in three-prime repair exonuclease-1 (TREX1) gene, c.703_704insG (p...
  37. Yuan F, Dutta T, Wang L, Song L, Gu L, Qian L, et al. Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA. J Biol Chem. 2015;290:13344-53 pubmed publisher
    3' repair exonuclease 1 (TREX1) is a known DNA exonuclease involved in autoimmune disorders and the antiviral response. In this work, we show that TREX1 is also a RNA exonuclease...
  38. Vargas G, Lastra L, Ramírez G, Solís M. The Diatraea Complex (Lepidoptera: Crambidae) in Colombia's Cauca River Valley: Making a Case for the Geographically Localized Approach. Neotrop Entomol. 2018;47:395-402 pubmed publisher
    ..indigenella Dyar & Heinrich are common pests of sugarcane crops in Colombia's Cauca river valley (CRV). In 2012, however, D. tabernella Dyar was recorded for the first time in northern CRV and just 1 year later, D...
  39. Ozer E, Goktaş M, Toker A, Bariskaner H, Ugurluoglu C, Iskit A. Effects of Carvacrol on Survival, Mesenteric Blood Flow, Aortic Function and Multiple Organ Injury in a Murine Model of Polymicrobial Sepsis. Inflammation. 2017;40:1654-1663 pubmed publisher
    Carvacrol (CRV) has strong cytoprotective, antioxidant, and anti-inflammatory properties...
  40. Zhou H, Wu Y, Feng L, Liu D. A Security Mechanism for Cluster-Based WSN against Selective Forwarding. Sensors (Basel). 2016;16: pubmed
    ..in order to take both the safety and the lifespan of a network into consideration, the composite reputation value (CRV) including forwarding rate, detecting malicious nodes, and surplus energy of the node is utilized to select CH and ..
  41. Leotte J, Trombetta H, Faggion H, Almeida B, Nogueira M, Vidal L, et al. Impact and seasonality of human rhinovirus infection in hospitalized patients for two consecutive years. J Pediatr (Rio J). 2017;93:294-300 pubmed publisher
    ..and outcomes of human rhinovirus (HRV) infections in comparison with other community acquired respiratory virus (CRV) infections in patients hospitalized for two consecutive years. This was a cross-sectional study...
  42. Tolmie J, Shillito P, Hughes Benzie R, Stephenson J. The Aicardi-Goutières syndrome (familial, early onset encephalopathy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosis). J Med Genet. 1995;32:881-4 pubmed
    ..The syndrome has superficial resemblance to the neurological sequelae of congenital infection, thus a rigorous search for microbiological and serological evidence of embryopathic infections should be carried out in each case. ..
  43. Yoshioka K, Yoshioka Y, Hsieh P. ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol Cell. 2006;22:501-10 pubmed
    ..These results suggest that MMR proteins can act as direct sensors of methylation damage and help recruit ATR-ATRIP to sites of cytotoxic O(6)-meG adducts to initiate ATR checkpoint signaling. ..
  44. Brucet M, Querol Audi J, Serra M, Ramirez Espain X, Bertlik K, Ruiz L, et al. Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains. J Biol Chem. 2007;282:14547-57 pubmed
    b>TREX1 is the most abundant mammalian 3' --> 5' DNA exonuclease. It has been described to form part of the SET complex and is responsible for the Aicardi-Goutières syndrome in humans...
  45. Crozat K, Vivier E, Dalod M. Crosstalk between components of the innate immune system: promoting anti-microbial defenses and avoiding immunopathologies. Immunol Rev. 2009;227:129-49 pubmed publisher
  46. Pak V, Eifler T, Jäger S, Krogan N, Fujinaga K, Peterlin B. CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing. Cell Host Microbe. 2015;18:560-70 pubmed publisher
    ..In contrast, higher levels of CDK11 increased the length of HIV poly(A) tails and the stability of mature viral transcripts. We conclude that CDK11 plays a critical role for the cotranscriptional processing of all HIV mRNA species. ..
  47. Wilson R, Espinosa Díez C, Kanner N, Chatterjee N, Ruhl R, Hipfinger C, et al. MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment. Nat Commun. 2016;7:13597 pubmed publisher
    ..Mechanistically, miR-103 regulation of its target gene TREX1 in endothelial cells governs the secretion of pro-inflammatory cytokines into the tumour microenvironment...
  48. Golestani A, Kwinta J, Khatamian Y, Chen J. The Effect of Low-Frequency Physiological Correction on the Reproducibility and Specificity of Resting-State fMRI Metrics: Functional Connectivity, ALFF, and ReHo. Front Neurosci. 2017;11:546 pubmed publisher
    ..signal is affected by a variety of low-frequency physiological phenomena, including variations in cardiac-rate (CRV), respiratory-volume (RVT), and end-tidal CO2 (PETCO2)...
  49. Haaxma C, Crow Y, van Steensel M, Lammens M, Rice G, Verbeek M, et al. A de novo p.Asp18Asn mutation in TREX1 in a patient with Aicardi-Goutières syndrome. Am J Med Genet A. 2010;152A:2612-7 pubmed publisher
    ..Mutations in the TREX1 gene are found in approximately 25% of patients...
  50. Miyazaki T, Kim Y, Yoon J, Wang H, Suzuki T, Morse H. The 3'-5' DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response. J Biol Chem. 2014;289:32548-58 pubmed publisher
    The main function of the 3'-5' DNA exonuclease TREX1 is to digest cytosolic single-stranded DNA to prevent activation of cell-intrinsic responses to immunostimulatory DNA...
  51. Vanhoudt A, van Hees Huijps K, van Knegsel A, Sampimon O, Vernooij J, Nielen M, et al. Effects of reduced intramammary antimicrobial use during the dry period on udder health in Dutch dairy herds. J Dairy Sci. 2018;101:3248-3260 pubmed publisher
    ..The herd level analysis was carried out using key performance indicators provided via milk recording (CRV, Arnhem, the Netherlands): the percentage of cows that developed a new intramammary infection (IMI) during the dry ..
  52. Booiman T, Setiawan L, Kootstra N. Genetic variation in Trex1 affects HIV-1 disease progression. AIDS. 2014;28:2517-21 pubmed publisher
    b>Three prime repair exonuclease 1 (TREX1) plays a pivotal role in HIV-1 infection...
  53. Günther C, Berndt N, Wolf C, Lee Kirsch M. Familial chilblain lupus due to a novel mutation in the exonuclease III domain of 3' repair exonuclease 1 (TREX1). JAMA Dermatol. 2015;151:426-31 pubmed publisher
    ..Familial chilblain lupus is usually caused by a mutation in TREX1 (3' repair exonuclease 1)...
  54. Yu T, Zhang X, Zhong L, Cui Q, Hu X, Li B, et al. The use of a 0.20 ?m particulate matter filter decreases cytotoxicity in lung epithelial cells following air-liquid interface exposure to motorcycle exhaust. Environ Pollut. 2017;227:287-295 pubmed publisher
    ..Lung epithelial cells were exposed to clean air, fME, or non-fME in the ALI chamber. Cell relative viabilities (CRV) and the reactive oxygen species (ROS) generation were determined. Our results revealed that PM2...
  55. Sassi C, Nalls M, Ridge P, Gibbs J, Lupton M, Troakes C, et al. Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. Neurobiol Aging. 2018;66:179.e17-179.e29 pubmed publisher
    ..present with rapidly progressive dementia as dominant feature and are caused by mutations in NOTCH3, HTRA1, TREX1, ARSA, CSF1R, EIF2B1, EIF2B2, EIF2B3, EIF2B4, and EIF2B5, respectively...
  56. Tornuk F, Sagdic O, Hancer M, Yetim H. Development of LLDPE based active nanocomposite films with nanoclays impregnated with volatile compounds. Food Res Int. 2018;107:337-345 pubmed publisher
    ..MMT) and halloysite (HNT)) with essential oil constituents (thymol (THY), eugenol (EUG) and carvacrol (CRV)) using Tween 80 as surfactant and then the nanoclay particles were incorporated into LLDPE pellets (5 wt%) ..
  57. Black D, Watters G, Andermann E, Dumont C, Kabay M, Kaplan P, et al. Encephalitis among Cree children in northern Quebec. Ann Neurol. 1988;24:483-9 pubmed
    ..The familial incidence of cases and the high degree of parental consanguinity suggest a genetic contribution. We propose that this entity may be caused by an unusual viral infection in a genetically vulnerable host. ..
  58. Hur J, Sung Y, Shin H, Park B, Cheong H, Bae S. TREX1 polymorphisms associated with autoantibodies in patients with systemic lupus erythematosus. Rheumatol Int. 2008;28:783-9 pubmed
    Three-prime repair exonucleases 1 and 2 (TREX1 and TREX2) play a role in the metabolism and clearance of DNA...
  59. Hasan M, Dobbs N, Khan S, White M, Wakeland E, Li Q, et al. Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice. J Immunol. 2015;195:4573-7 pubmed publisher
    ..Compound II treatment also ameliorated autoimmune disease phenotypes of Trex1(-/-) mice, increased mouse survival, and dampened the IFN gene signature in TREX1 mutant patient lymphoblasts...
  60. Yamazaki T, Galluzzi L. TREX1 Cuts Down on Cancer Immunogenicity. Trends Cell Biol. 2017;27:543-545 pubmed publisher
    Demaria and colleagues have recently identified three prime repair exonuclease 1 (TREX1) as a key determinant for the limited immunogenicity of cancer cells responding to single high-dose radiation...
  61. Yanai H, Savitsky D, Tamura T, Taniguchi T. Regulation of the cytosolic DNA-sensing system in innate immunity: a current view. Curr Opin Immunol. 2009;21:17-22 pubmed publisher
    ..In particular, DAI (DLM-1/ZBP1), Trex1, and other regulators of the cytosolic DNA-sensing system have recently been identified and characterized...
  62. Bailey S, Harvey S, Perrino F, Hollis T. Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease. DNA Repair (Amst). 2012;11:65-73 pubmed publisher
    Mutations within the human TREX1 3' exonuclease are associated with Aicardi-Goutières Syndrome (AGS) and familial chilblain lupus (FCL)...
  63. La Piana R, Uggetti C, Roncarolo F, Vanderver A, Olivieri I, Tonduti D, et al. Neuroradiologic patterns and novel imaging findings in Aicardi-Goutières syndrome. Neurology. 2016;86:28-35 pubmed publisher
    ..Brain calcifications were present in 110 subjects (90.9%). Severe calcification was associated with TREX1 mutations and early age at onset. Cerebral atrophy was documented in 111 subjects (91.8%)...
  64. Hasan M, Gonugunta V, Dobbs N, Ali A, Palchik G, Calvaruso M, et al. Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism. Proc Natl Acad Sci U S A. 2017;114:746-751 pubmed publisher
    Three-prime repair exonuclease 1 knockout (Trex1-/-) mice suffer from systemic inflammation caused largely by chronic activation of the cyclic GMP-AMP synthase-stimulator of interferon genes-TANK-binding kinase-interferon ..
  65. Yan N. Immune Diseases Associated with TREX1 and STING Dysfunction. J Interferon Cytokine Res. 2017;37:198-206 pubmed publisher
    ..This review will focus on TREX1 and STING, which are opposing regulators of the cytosolic DNA-sensing pathway...
  66. Kisla Ekinci R, Balci S, Bisgin A, Altintas D, Yilmaz M. A homozygote TREX1 mutation in two siblings with different phenotypes: Chilblains and cerebral vasculitis. Eur J Med Genet. 2017;60:690-694 pubmed publisher
    b>Three prime repair exonuclease 1 degrades single and double stranded DNA with 3'-5' nuclease activity and its mutations are related to type 1 IFN mediated autoinflammation due to accumulated intracellular nucleic acids...
  67. Al Mutairi F, Alfadhel M, Nashabat M, El Hattab A, Ben Omran T, Hertecant J, et al. Phenotypic and Molecular Spectrum of Aicardi-Goutières Syndrome: A Study of 24 Patients. Pediatr Neurol. 2018;78:35-40 pubmed publisher
    ..2%). Homozygous mutations were identified in RNASEH2B (54.2%), RNASEH2A (20.8%), RNASEH2C (8.3%), SAMHD1 (8.3%), TREX1 (4.2%), and heterozygous mutations in IFIH1 (4.2%), with c.356A>G (p...
  68. Wu Y, Yu H, Tang H, Su Y, Shi T, Liu S, et al. PXR polymorphisms have impact on the clinical efficacy of clopidogrel in patients undergoing percutaneous coronary intervention. Gene. 2018;653:22-28 pubmed publisher
    ..However, clopidogrel response variability (CRV) may affect the patients' clinical outcomes...
  69. Alves C, Granados O, Budaszewski R, Streck A, Weber M, Cibulski S, et al. Identification of enteric viruses circulating in a dog population with low vaccine coverage. Braz J Microbiol. 2018;49:790-794 pubmed publisher
    ..such as Canine adenovirus (CAdV), Canine coronavirus (CCoV), Canine distemper virus (CDV), Canine rotavirus (CRV) and Carnivorous protoparvovirus 1 (canine parvovirus 2; CPV-2). At least one of these species was detected in 56...
  70. Orebaugh C, Fye J, Harvey S, Hollis T, Perrino F. The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity. J Biol Chem. 2011;286:40246-54 pubmed publisher
    Mutations in the TREX1 gene cause Aicardi-Goutières syndrome (AGS) and are linked to the autoimmune disease systemic lupus erythematosus...
  71. Tomicic M, Aasland D, Nikolova T, Kaina B, Christmann M. Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs. Biochim Biophys Acta. 2013;1833:1832-43 pubmed publisher
    ..Here, we provide evidence that the "three prime exonuclease I" (TREX1) is up-regulated in human fibroblasts and cancer cells on mRNA and protein level...
  72. Abe J, Nakamura K, Nishikomori R, Kato M, Mitsuiki N, Izawa K, et al. A nationwide survey of Aicardi-Goutières syndrome patients identifies a strong association between dominant TREX1 mutations and chilblain lesions: Japanese cohort study. Rheumatology (Oxford). 2014;53:448-58 pubmed publisher
    ..Three patients harboured dominant-type TREX1 mutations. These included two de novo cases: one caused by a novel heterozygous p...
  73. Shinozuka K, Tang H, Jones R, Li D, Nieto Y. Impact of Polymorphic Variations of Gemcitabine Metabolism, DNA Damage Repair, and Drug-Resistance Genes on the Effect of High-Dose Chemotherapy for Relapsed or Refractory Lymphoid Malignancies. Biol Blood Marrow Transplant. 2016;22:843-9 pubmed publisher
    ..and hCNT3; DNA damage repair genes RECQL, X-ray repair complementing 1, RAD54L, ATM, ATR, MLH1, MSH2, MSH3, TREX1, EXO1, and TP73; and multidrug-resistance genes MRP2 and MRP5; as well as glutathione-S-transferase GSTP1 in 153 ..
  74. Feng J, Lan R, Cai G, Lin J, Wang X, Lin J, et al. Verification of TREX1 as a promising indicator of judging the prognosis of osteosarcoma. J Orthop Surg Res. 2016;11:150 pubmed
    The study aimed to explore the correlation between the expression of TREX1 and the metastasis and the survival time of patients with osteosarcoma as well as biological characteristics of osteosarcoma cells for the prognosis judgment of ..
  75. Thomas C, Tejwani L, Trujillo C, Negraes P, Herai R, Mesci P, et al. Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation. Cell Stem Cell. 2017;21:319-331.e8 pubmed publisher
    Three-prime repair exonuclease 1 (TREX1) is an anti-viral enzyme that cleaves nucleic acids in the cytosol, preventing accumulation and a subsequent type I interferon-associated inflammatory response...
  76. Fredi M, Bianchi M, Andreoli L, Greco G, Olivieri I, Orcesi S, et al. Typing TREX1 gene in patients with systemic lupus erythematosus. Reumatismo. 2015;67:1-7 pubmed publisher
    ..One of mutations causing AGS is located in the TREX1 gene on chromosome 3. Heterozygous mutations in TREX1 were reported in SLE patients...
  77. Azzouz D, Martin G, Arnoux F, Balandraud N, Martin T, Dubucquoi S, et al. Anti-Ephrin Type-B Receptor 2 (EphB2) and Anti-Three Prime Histone mRNA EXonuclease 1 (THEX1) Autoantibodies in Scleroderma and Lupus. PLoS ONE. 2016;11:e0160283 pubmed publisher
    ..We have further identified a peptide from EphB2 as a specific and sensitive tool for SLE diagnosis. ..
  78. Vanpouille Box C, Formenti S, Demaria S. TREX1 dictates the immune fate of irradiated cancer cells. Oncoimmunology. 2017;6:e1339857 pubmed publisher
    ..We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated cancer cells by degrading interferon-stimulatory cytosolic dsDNA...
  79. Crow Y, Black D, Ali M, Bond J, Jackson A, Lefson M, et al. Cree encephalitis is allelic with Aicardi-Goutiéres syndrome: implications for the pathogenesis of disorders of interferon alpha metabolism. J Med Genet. 2003;40:183-7 pubmed
    ..Moreover, linkage analysis indicates that the disorders are allelic and refines the AGS1 locus to a 3.47 cM critical interval...
  80. Neidhart M, Karouzakis E, Schumann G, Gay R, Gay S. Trex-1 deficiency in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 2010;62:2673-9 pubmed publisher
    ..This pathway may play a role in diseases in which the cells exhibit a "spontaneous" aggressive behavior. ..
  81. Fye J, Orebaugh C, Coffin S, Hollis T, Perrino F. Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome. J Biol Chem. 2011;286:32373-82 pubmed publisher
    b>TREX1 is a potent 3' ? 5' exonuclease that degrades single- and double-stranded DNA (ssDNA and dsDNA)...
  82. Pelzer N, de Vries B, Boon E, Kruit M, Haan J, Ferrari M, et al. Heterozygous TREX1 mutations in early-onset cerebrovascular disease. J Neurol. 2013;260:2188-90 pubmed publisher
  83. Barizzone N, Monti S, Mellone S, Godi M, Marchini M, Scorza R, et al. Rare variants in the TREX1 gene and susceptibility to autoimmune diseases. Biomed Res Int. 2013;2013:471703 pubmed publisher
    TREX1 (DNase III) is an exonuclease involved in response to oxidative stress and apoptosis. Heterozygous mutations in TREX1 were previously observed in patients with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS)...
  84. Livingston J, Crow Y. Neurologic Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, and IFIH1: Aicardi-Goutières Syndrome and Beyond. Neuropediatrics. 2016;47:355-360 pubmed
    ..is now recognized that mutations in any of the following seven genes may result in the classical AGS phenotype: TREX1 (AGS1), RNASEH2A (AGS2), RNASEH2B (AGS3), RNASEH2C (AGS4), SAMHD1 (AGS5), ADAR1<..
  85. Pelzer N, Bijkerk R, Reinders M, van Zonneveld A, Ferrari M, van den Maagdenberg A, et al. Circulating Endothelial Markers in Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations. Stroke. 2017;48:3301-3307 pubmed publisher
    ..and systemic manifestations (RVCL-S) is a monogenic small vessel disease, caused by C-terminal truncating TREX1 mutations, that can be considered a model for stroke and vascular dementia...
  86. Perrino F, Miller H, Ealey K. Identification of a 3'-->5'-exonuclease that removes cytosine arabinoside monophosphate from 3' termini of DNA. J Biol Chem. 1994;269:16357-63 pubmed
    ..The enzymatic characteristics of the isolated 3'-->5'-exonuclease indicate that it is distinct from previously identified mammalian deoxyribonucleases. ..
  87. Günther C, Hillebrand M, Brunk J, Lee Kirsch M. Systemic involvement in TREX1-associated familial chilblain lupus. J Am Acad Dermatol. 2013;69:e179-81 pubmed publisher
  88. Peschke K, Friebe F, Zimmermann N, Wahlicht T, Schumann T, Achleitner M, et al. Deregulated type I IFN response in TREX1-associated familial chilblain lupus. J Invest Dermatol. 2014;134:1456-1459 pubmed publisher
  89. Raafat D, Leib N, Wilmes M, Francois P, Schrenzel J, Sahl H. Development of in vitro resistance to chitosan is related to changes in cell envelope structure of Staphylococcus aureus. Carbohydr Polym. 2017;157:146-155 pubmed publisher
    ..aureus SG511-Berlin. Following a serial passage experiment, a stable chitosan-resistant variant (CRV) was identified, exhibiting >50-fold reduction in its sensitivity towards chitosan...
  90. Rice G, Patrick T, Parmar R, Taylor C, Aeby A, Aicardi J, et al. Clinical and molecular phenotype of Aicardi-Goutieres syndrome. Am J Hum Genet. 2007;81:713-25 pubmed
    ..AGS exhibits locus heterogeneity, with mutations identified in genes encoding the 3'-->5' exonuclease TREX1 and the three subunits of the RNASEH2 endonuclease complex...
  91. Achleitner M, Kleefisch M, Hennig A, Peschke K, Polikarpova A, Oertel R, et al. Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs. J Immunol. 2017;199:2261-2269 pubmed publisher
    Biallelic mutations of three prime repair exonuclease 1 (TREX1) cause the lupus-like disease Aicardi-Goutières syndrome in which accumulation of a yet unknown endogenous DNA substrate of TREX1 triggers a cyclic GMP-AMP synthase-dependent ..