Gene Symbol: TRB
Description: T cell receptor beta locus
Alias: TCRB, TRB@, T-cell antigen receptor, beta polypeptide, T-cell receptor, beta cluster, T-cell receptor, beta cluster, TCRB, TRB@
Species: human
Products:     TRB

Top Publications

  1. Borbulevych O, Piepenbrink K, Baker B. Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics. J Immunol. 2011;186:2950-8 pubmed publisher
  2. Scott D, Borbulevych O, Piepenbrink K, CORCELLI S, Baker B. Disparate degrees of hypervariable loop flexibility control T-cell receptor cross-reactivity, specificity, and binding mechanism. J Mol Biol. 2011;414:385-400 pubmed publisher
  3. Holland C, Rizkallah P, Vollers S, Calvo Calle J, Madura F, Fuller A, et al. Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers. Sci Rep. 2012;2:629 pubmed publisher
    ..Thermodynamic analysis revealed that limited plasticity and extreme favorable entropy underpinned the ability of the HA1.7 T-cell clone to cross-react with HA(306-318) presented by multiple MHC-II alleles. ..
  4. Novais C, Campos J, Freitas A, Barros M, Silveira E, Coque T, et al. Water supply and feed as sources of antimicrobial-resistant Enterococcus spp. in aquacultures of rainbow trout (Oncorhyncus mykiss), Portugal. Sci Total Environ. 2018;625:1102-1112 pubmed publisher
    ..Multiple MDR clones carrying copper tolerance (tcrB/cueO), putative virulence or other genes often associated with clinical strains (e.g. E...
  5. Valero Y, Mokrani D, Chaves Pozo E, Arizcun M, Oumouna M, Meseguer J, et al. Vaccination with UV-inactivated nodavirus partly protects European sea bass against infection, while inducing few changes in immunity. Dev Comp Immunol. 2018;86:171-179 pubmed publisher brain, while in the head-kidney the transcription of mhc1a, mhc2b and cd8a was down-regulated and mx, isg15 and tcrb was up-regulated...
  6. Ahn M, Kim M, Kwon R, Hwang J, Park K. Gene expression profiling and inhibition of adipose tissue accumulation of G. bimaculatus extract in rats on high fat diet. Lipids Health Dis. 2015;14:116 pubmed publisher
    ..ligand 21b), Glycan1 (glycosylation dependent cell adhesion moleule, Serpinb1a (serine proteinase inhibitor) and Tcrb (T-cell receptor beta chain)...
  7. Valero Y, Awad E, Buonocore F, Arizcun M, Esteban M, Meseguer J, et al. An oral chitosan DNA vaccine against nodavirus improves transcription of cell-mediated cytotoxicity and interferon genes in the European sea bass juveniles gut and survival upon infection. Dev Comp Immunol. 2016;65:64-72 pubmed publisher
    ..However, the vaccine up-regulated the expression of genes related to the cell-mediated cytotoxicity (CMC; tcrb and cd8a) and the interferon pathway (IFN; ifn, mx and ifng)...
  8. Luksch H, Stinson W, Platt D, Qian W, Kalugotla G, Miner C, et al. STING-associated lung disease in mice relies on T cells but not type I interferon. J Allergy Clin Immunol. 2019;: pubmed publisher
    ..STING N153S mice that lack adaptive immunity had no lung disease, and T-cell receptor β chain (Tcrb)-/- STING N153S animals only had mild disease...
  9. Tokunaga M, Yoshida N, Nakano N, Kubota A, Takeuchi S, Takatsuka Y, et al. Detection of an early adult T-cell leukemia-lymphoma clone in lymph nodes with anaplastic lymphoma kinase-negative anaplastic large cell lymphoma involvement. Cancer Genet. 2016;209:138-42 pubmed publisher
    ..Southern blot analysis revealed monoclonal integration of HTLV-1 provirus DNA and monoclonal rearrangement of TRB. He was diagnosed with chronic type adult T-cell leukemia-lymphoma (ATL), which immediately progressed to the acute ..

More Information

Publications163 found, 100 shown here

  1. Singhal G, Fisher F, Chee M, Tan T, El Ouaamari A, Adams A, et al. Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. PLoS ONE. 2016;11:e0148252 pubmed publisher
    ..Inflammatory infiltrates consist of TCRb+ Thy1+ T lymphocytes with increased levels of Foxp3+ regulatory T cells...
  2. De Sotto R, Medriano C, Salcedo D, Lee H, Cho Y, Kim S. Effects of solids retention time on the fate of tetracycline resistance in SBRs for the treatment of carcass leachate. J Environ Manage. 2016;181:298-303 pubmed publisher
    ..Solids retention time contributed to an increase in antibiotic resistance in SBRC (SRT = 25 days) with TRB values up to 1.25 × 10(7) CFU/mL which is one log higher than the influent...
  3. Pietrangeli D, Rosa A, Pepe A, Altieri S, Bortolussi S, Postuma I, et al. Water-soluble carboranyl-phthalocyanines for BNCT. Synthesis, characterization, and in vitro tests of the Zn(II)-nido-carboranyl-hexylthiophthalocyanine. Dalton Trans. 2015;44:11021-8 pubmed publisher
    ..showed that 7 is capable of increasing the boron concentration of two selected cancerous cell lines, the DHD/K12/TRb of rat colon adenocarcinoma and UMR-106 of rat osteosarcoma, with the large-size Cs(+) counter-ions used to ..
  4. Boone E, Heezen K, Groenen P, Langerak A. PCR GeneScan and Heteroduplex Analysis of Rearranged Immunoglobulin or T-Cell Receptor Genes for Clonality Diagnostics in Suspect Lymphoproliferations. Methods Mol Biol. 2019;1956:77-103 pubmed publisher
    ..describe an integrated approach to assess clonality via analysis of Ig heavy chain (IGH), Ig kappa (IGK), TCR beta (TRB), and TCR gamma (TRG) gene rearrangements, based on the standardized multiplex PCRs as originally developed by the ..
  5. Ott de Bruin L, Bosticardo M, Barbieri A, Lin S, Rowe J, Poliani P, et al. Hypomorphic Rag1 mutations alter the pre-immune repertoire at early stages of lymphoid development. Blood. 2018;: pubmed publisher
    ..By using high throughput sequencing, we identified marked skewing of Igh V and Trb V gene usage in early progenitors, with a bias for productive Igh and Trb rearrangements after selection occurred ..
  6. Pan S, Ko Y, Tan S, Chuang S. Primary cutaneous peripheral T-cell lymphoma with a late relapse solely in the ileum mimicking monomorphic epitheliotropic intestinal T-cell lymphoma. Pathol Res Pract. 2018;214:2106-2109 pubmed publisher
    ..Clonality study showed clonal TRG and TRB rearrangement with identical band sizes of the amplicons, confirming primary cutaneous tumor with a late relapse in ..
  7. Rojo Bezares B, Azcona Gutiérrez J, Martin C, Jareño M, Torres C, Saenz Y. Streptococcus agalactiae from pregnant women: antibiotic and heavy-metal resistance mechanisms and molecular typing. Epidemiol Infect. 2016;144:3205-3214 pubmed
    ..We report, for the first time, the detection of cadmium and copper resistance encoded by tcrB + cadA + cadC genes in 20 M+/-LR strains, which raises the possibility of co-selection of antibiotic and heavy-..
  8. Wang P, Zhao Y, Jiang N, Li K, Xing T, Chen L, et al. Effects of water-misting spray combined with forced ventilation on heat induced meat gelation in broiler after summer transport. Poult Sci. 2016;95:2441-8 pubmed publisher
    ..05). TWFR, 45 min of transport, 1 h rest, and addition of sodium bicarbonate (TRB) and TRT induced T22 (relaxation time of water trapped within myofibrils) shift to shorter relaxation time and ..
  9. Silva W, Gonçalves S, Santos D, Padovan A, Bizerra F, Melo A. Species diversity, antifungal susceptibility and phenotypic and genotypic characterisation of Exophiala spp. infecting patients in different medical centres in Brazil. Mycoses. 2017;60:328-337 pubmed publisher
    ..B (AMB), itraconazole (ITC), voriconazole (VRC), posaconazole (PSC), caspofungin (CFG) and terbinafine (TRB). The ITS analysis identified 100% of the following isolates as: E. dermatitidis (8), E. xenobiotica (6), E...
  10. Kirbaeva N, Sharanova N, Zhminchenko V, Toropygin I, Koplik E, Pertsov S, et al. Effect of Coenzyme Q10 on Proteomic Profile of Rat Brain Amygdala during Acute Metabolic Stress. Bull Exp Biol Med. 2016;161:460-4 pubmed publisher
    ..peroxiredoxin-2, calcineurin B homologous protein 1, Ras-related protein Rab-14, glutathione S-transferase omega-1, Tcrb protein, and NADH dehydrogenase [ubiquinone] iron-sulfur protein 8 (mitochondrial) was shown to depend on the ..
  11. Breaux B, Hunter M, Cruz Schneider M, Sena L, Bonde R, Criscitiello M. The Florida manatee (Trichechus manatus latirostris) T cell receptor loci exhibit V subgroup synteny and chain-specific evolution. Dev Comp Immunol. 2018;85:71-85 pubmed publisher
    ..There were extensive V subgroup synteny blocks in the TRA and TRB loci between T. m. latirostris and human. Increased genomic locus complexity correlated to increased locus synteny...
  12. Shao S, Zhang X, Van Heusden G, Hooykaas P. Complete sequence of the tumor-inducing plasmid pTiChry5 from the hypervirulent Agrobacterium tumefaciens strain Chry5. Plasmid. 2018;96-97:1-6 pubmed publisher
    ..The remaining part of pTiChry5 is less related to that of pTiBo542 and embraces the trb operon of conjugation genes, genes involved in the catabolism of Amadori opines and the gene for chrysopine synthase,..
  13. Tong W, Callahan B, Tu Y, Zaman S, Chobrutskiy B, Blanck G. Immune receptor recombinations from breast cancer exome files, independently and in combination with specific HLA alleles, correlate with better survival rates. Breast Cancer Res Treat. 2019;173:167-177 pubmed publisher
    ..014) compared to all other breast cancer samples. By direct comparisons of distinct TRB gene segment usage, HLA allele combinations revealed breast cancer subgroups, within the entire TCGA breast cancer ..
  14. Rechavi E, Lev A, Lee Y, Simon A, Yinon Y, Lipitz S, et al. Timely and spatially regulated maturation of B and T cell repertoire during human fetal development. Sci Transl Med. 2015;7:276ra25 pubmed publisher
    ..Using next-generation sequencing, we analyzed the diversity and complexity of T cell receptor β (TRB) and immunoglobulin heavy chain (IGH) repertoires in four fetuses at 12, 13, 22, and 26 weeks of gestation and in ..
  15. Yiasemidou M, Munir U, Glassman D, Teanby D. Efficacy and Safety of a Biweekly Viscosupplementation Regimen for Knee Osteoarthritis. J Knee Surg. 2016;29:63-7 pubmed publisher
    ..Patients were given three sodium hyaluronate isotonic solution injections (Ostenil; TRB Chemedica SA, Vouvry, Switzerland), biweekly...
  16. Minervina A, Komkov A, Mamedov I, Lebedev Y. Advanced lymphoblastic clones detection in T-cell leukemia. Dokl Biochem Biophys. 2016;467:85-8 pubmed publisher
    ..of the system on genomic DNA from Jurkat cell line and four clinical bone marrow aspirates revealed a set of unique TRB rearrangements that precisely characterize each of tested samples...
  17. Guevara Suarez M, Sutton D, Cano Lira J, García D, Martin Vicente A, Wiederhold N, et al. Identification and Antifungal Susceptibility of Penicillium-Like Fungi from Clinical Samples in the United States. J Clin Microbiol. 2016;54:2155-61 pubmed publisher
    ..citrinum, and Talaromyces amestolkiae The potent in vitro activity of amphotericin B (AMB) and terbinafine (TRB) and of the echinocandins against Penicillium and Talaromyces species might offer a good therapeutic alternative ..
  18. Yue Y, Leung S, Liu Y, Huang Y, Grundt K, Østvold A, et al. Nucks1 synergizes with Trp53 to promote radiation lymphomagenesis in mice. Oncotarget. 2016;7:61874-61889 pubmed publisher
    ..Monoclonal rearrangements at Tcrb were more prevalent in TLs from Trp53+/- Nucks1+/- mice, as was infiltration of primary TL cells to distant organs (..
  19. De la Garza Bravo M, Patel K, Loghavi S, Curry J, Torres Cabala C, Cason R, et al. Shared clonality in distinctive lesions of lymphomatoid papulosis and mycosis fungoides occurring in the same patients suggests a common origin. Hum Pathol. 2015;46:558-69 pubmed publisher
    ..We used polymerase chain reaction-based methods to assess the TCR-β chain (TCRB) and TCR-γ chain (TCRG) in both LyP and MF lesions of all patients...
  20. Zoutman W, Nell R, van der Velden P. Usage of Droplet Digital PCR (ddPCR) Assays for T Cell Quantification in Cancer. Methods Mol Biol. 2019;1884:1-14 pubmed publisher
    ..1 genes (TRB locus)...
  21. Theunissen P, de Bie M, van Zessen D, de Haas V, Stubbs A, van der Velden V. Next-generation antigen receptor sequencing of paired diagnosis and relapse samples of B-cell acute lymphoblastic leukemia: Clonal evolution and implications for minimal residual disease target selection. Leuk Res. 2019;76:98-104 pubmed publisher
    ..We evaluated 42 paired diagnosis-relapse samples by NGS (IGH, IGK, TRG, TRD, and TRB) to evaluate clonal evolution patterns and to design an algorithm for selection of antigen receptor gene ..
  22. Shao H, Lin Y, Wang T, Ou Y, Shen H, Tao C, et al. Identification of peptide-specific TCR genes by in vitro peptide stimulation and CDR3 length polymorphism analysis. Cancer Lett. 2015;363:83-91 pubmed publisher
    ..The monoclonal expansion of TCRA and TCRB genes was separately identified by Immunoscope analysis and following sequence identification, the properly paired ..
  23. Zhang Q, Jia Q, Deng T, Song B, Li L. Heterogeneous expansion of CD4+ tumor-infiltrating T-lymphocytes in clear cell renal cell carcinomas. Biochem Biophys Res Commun. 2015;458:70-6 pubmed publisher
    ..We utilized deep sequencing of T-cell receptor beta chains (TCRB), which serve as a unique identifier for each T clonotype, to characterize the CD4+/CD8+ TIL repertoire in ccRCC ..
  24. Kang Y, Li Q, Xia D, Shen M, Mei L, Hu J. Short-term thermophilic treatment cannot remove tetracycline resistance genes in pig manures but exhibits controlling effects on their accumulation and spread in soil. J Hazard Mater. 2017;340:213-220 pubmed publisher
    ..Nutrients enrichment in soil following manuring of treated pig manures, together with a large proportion of gram-positive TRB left in treated pig manures with less risk to TRGs spread, contributed to the controlling effects.
  25. Zacarías Cabeza J, Belhocine M, Vanhille L, Cauchy P, Koch F, Pekowska A, et al. Transcription-dependent generation of a specialized chromatin structure at the TCRβ locus. J Immunol. 2015;194:3432-43 pubmed publisher
    ..We show that extended H3K4 trimethylation at the Tcrb locus depends on RNA polymerase II (Pol II)-mediated transcription...
  26. Jiang T, Raviram R, Snetkova V, Rocha P, Proudhon C, Badri S, et al. Identification of multi-loci hubs from 4C-seq demonstrates the functional importance of simultaneous interactions. Nucleic Acids Res. 2016;44:8714-8725 pubmed
    ..of our method using 4C-seq data sets that identify known pairwise and novel tri-loci interactions involving the Tcrb and Igk antigen receptor enhancers...
  27. Zoutman W, Nell R, Versluis M, van Steenderen D, Lalai R, Out Luiting J, et al. Accurate Quantification of T Cells by Measuring Loss of Germline T-Cell Receptor Loci with Generic Single Duplex Droplet Digital PCR Assays. J Mol Diagn. 2017;19:236-243 pubmed publisher
    ..These assays target sequences between the D?2 and D?3 genes (TRD locus) and D?1 and J?1.1 genes (TRB locus) that become deleted systematically early during lymphoid differentiation...
  28. Kløverpris H, McGregor R, McLaren J, Ladell K, Harndahl M, Stryhn A, et al. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J Immunol. 2015;194:5329-45 pubmed publisher
    ..immunodominance correlated with epitope-specific usage of public TCRs, defined as amino acid residue-identical TRB sequences that occur in multiple individuals...
  29. McCully M, Ladell K, Andrews R, Jones R, Miners K, Roger L, et al. CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin. J Immunol. 2018;200:1639-1650 pubmed publisher
    ..Importantly, conventional and high-throughput sequencing of expressed TCR β-chain (TRB) gene rearrangements showed that these CCR8-defined populations are clonotypically distinct, suggesting unique ..
  30. Huang H, Chen Y, Zheng X, Su Y, Wan R, Yang S. Distribution of tetracycline resistance genes in anaerobic treatment of waste sludge: The role of pH in regulating tetracycline resistant bacteria and horizontal gene transfer. Bioresour Technol. 2016;218:1284-9 pubmed publisher revealed that varied pHs not only altered the community structures of tetracycline resistant bacteria (TRB), but also changed their relative abundances, benefitting the propagation (acidic pHs) or attenuation (alkaline pHs)..
  31. Proudhon C, Snetkova V, Raviram R, Lobry C, Badri S, Jiang T, et al. Active and Inactive Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation. Cell Rep. 2016;15:2159-2169 pubmed publisher
    ..that, in T cells, long-range contact and cooperation between the inactive Igk enhancer MiE? and the active Tcrb enhancer E? alters enrichment of CBF? binding in a manner that impacts Tcrb recombination...
  32. Schmitt T, Aggen D, Ishida Tsubota K, Ochsenreither S, Kranz D, Greenberg P. Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor T cells in vitro. Nat Biotechnol. 2017;: pubmed publisher
    ..The approach takes advantage of natural Tcrb gene rearrangement to generate diversity in the length and composition of CDR3?...
  33. Inano S, Kimura M, Iida J, Arima N. Combination therapy of voriconazole and terbinafine for disseminated fusariosis: case report and literature review. J Infect Chemother. 2013;19:1173-80 pubmed publisher
    ..the first case of disseminated Fusarium solani infection successfully treated by combination therapy of VRC and TRB accompanied by surgical resection of endocardial lesions...
  34. Vlachonikola E, Vardi A, Stamatopoulos K, Hadzidimitriou A. High-Throughput Sequencing of the T-Cell Receptor Beta Chain Gene Repertoire in Chronic Lymphocytic Leukemia. Methods Mol Biol. 2019;1881:355-363 pubmed publisher
    ..Here, we describe the experimental protocol that we developed for T-cell receptor beta chain (TRB) gene repertoire analysis in chronic lymphocytic leukemia, aiming to provide a reproducible and biologically ..
  35. Melenhorst J, Lay M, Price D, Adams S, Zeilah J, Sosa E, et al. Contribution of TCR-beta locus and HLA to the shape of the mature human Vbeta repertoire. J Immunol. 2008;180:6484-9 pubmed
    ..We therefore conclude that the correlation in Vbeta expression patterns between CD4(+) and CD8(+) T cells can be explained predominantly by germline TCR-beta locus factors and not TCR-beta allelic or HLA effects. ..
  36. Yassai M, Demos W, Gorski J. CDR3 motif generation and selection in the BV19-utilizing subset of the human CD8 T cell repertoire. Mol Immunol. 2016;72:57-64 pubmed publisher
    ..As these data were collected from an older healthy individual they can be used to model successful repertoire selection and to further define characteristics associated with a positive history of responses to pathogen exposures. ..
  37. Pedersen G, Àdori M, Khoenkhoen S, Dosenovic P, Beutler B, Karlsson Hedestam G. B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS. Proc Natl Acad Sci U S A. 2014;111:E4119-26 pubmed publisher
    ..Interestingly, we found that a subset of wt neonatal TrB cells expressed common B-1a markers (TrB-1a) and that this cell population was absent in the bumble neonatal spleen...
  38. Deniger D, Kwong M, Pasetto A, Dudley M, Wunderlich J, Langhan M, et al. A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma. Clin Cancer Res. 2017;23:351-362 pubmed publisher
    ..0. Metastases resected prior to and after 2 weeks of vemurafenib were compared using TCRB deep sequencing, immunohistochemistry, proliferation, and recognition of autologous tumor...
  39. May E, Lambert C, Holtmeier W, Hennemann A, Zeitz M, Duchmann R. Regional variation of the alphabeta T cell repertoire in the colon of healthy individuals and patients with Crohn's disease. Hum Immunol. 2002;63:467-80 pubmed
    ..the impact of CD on the regional distribution of expanded T cells, this study analyzed the T cell receptor beta (TCRB) repertoire within colonic biopsy specimens from 12 CD patients and 6 noninflammatory controls by TCR spectratyping...
  40. Malcolm T, Villarese P, Fairbairn C, Lamant L, Trinquand A, Hook C, et al. Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress. Nat Commun. 2016;7:10087 pubmed publisher
    ..Children affected by ALCL may thus harbour thymic lymphoma-initiating cells capable of seeding relapse after chemotherapy. ..
  41. Yoshida K, Cologne J, Cordova K, Misumi M, Yamaoka M, Kyoizumi S, et al. Aging-related changes in human T-cell repertoire over 20years delineated by deep sequencing of peripheral T-cell receptors. Exp Gerontol. 2017;96:29-37 pubmed publisher
    ..Sequence data at the hypervariable complementarity determining region 3 (CDR3) in the TCRB gene locus were evaluated by applying a random-coefficient statistical regression model...
  42. Mantaka P, Malecka A, Trøen G, Helsing P, Gjersvik P, Beiske K, et al. Folliculotropic Mycosis Fungoides with Skewed T-cell Receptor CDR3 Motif: Suggestive of Lipid-antigen Selection?. Acta Derm Venereol. 2017;97:1081-1086 pubmed publisher
    ..A recurrent usage of the TRB junctional genes TRBJ2-1 and TRBJ2-7 was found in patients with FMF compared with those with MF...
  43. Dresch C, Nardi N, Chies J. TCRBV3S1 and TCRBV18 gene segment polymorphisms in Brazilian Caucasoid and Black populations. Eur J Immunogenet. 2002;29:11-5 pubmed
  44. de Vries A, Langerak A, Verhaaf B, Niemeyer C, Stary J, Schmiegelow K, et al. T-cell receptor Vbeta CDR3 oligoclonality frequently occurs in childhood refractory cytopenia (MDS-RC) and severe aplastic anemia. Leukemia. 2008;22:1170-4 pubmed publisher
    ..Prospective studies are required to establish the clinical value of TCR Vbeta CDR3 repertoire analysis to predict the clinical response in these patients. ..
  45. Pierce B, Haidar J, Yu Y, Weng Z. Combinations of affinity-enhancing mutations in a T cell receptor reveal highly nonadditive effects within and between complementarity determining regions and chains. Biochemistry. 2010;49:7050-9 pubmed publisher
    ..These results highlight the complex nature of TCR association and binding and will be informative in future design efforts that combine multiple mutant residues. ..
  46. Parsons J, Antebi Gruszka N, Millar B, Cain D, Gurung S. Syndemic Conditions, HIV Transmission Risk Behavior, and Transactional Sex Among Transgender Women. AIDS Behav. 2018;22:2056-2067 pubmed publisher
    ..b>TRB was defined as the number of condomless penetrative sex events with a casual or main partner of discordant or ..
  47. Rawat P, Jalan M, Sadhu A, Kanaujia A, Srivastava M. Chromatin Domain Organization of the TCRb Locus and Its Perturbation by Ectopic CTCF Binding. Mol Cell Biol. 2017;37: pubmed publisher
    ..We analyzed the interactions among CTCF binding sites (CBS) at the murine TCRb locus to discern the role of CTCF-mediated interactions in the regulation of transcription and VDJ recombination...
  48. Xu C, Call M, Wucherpfennig K. A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor. J Biol Chem. 2006;281:36977-84 pubmed
    ..The three-chain interaction theme first established for the TM domains thus extends into the membrane-proximal domains of TCRalpha-CD3deltaepsilon and TCRbeta-CD3gammaepsilon. ..
  49. Thiel A, Kesselring R, Pries R, Puzik A, Wittkopf N, Wollenberg B. Expression of the T cell receptor ?? on a CD123+ BDCA2+ HLA-DR+ subpopulation in head and neck squamous cell carcinoma. PLoS ONE. 2011;6:e15997 pubmed publisher
    ..Our data indicate an interface between the PDC and T cell lineage. These findings will improve our understanding of phenotypical and functional intricacies concerning the very heterogeneous PDC population in-vivo. ..
  50. Shani N, Shinder V, Zipori D. Mitochondria as a sequestration site for incomplete TCR? peptides: the TCR? transmembrane domain is a sufficient mitochondrial targeting signal. Mol Immunol. 2011;49:239-52 pubmed publisher
    ..These results indicate that any given partial form of TCR?, that contains the TMD, is bound to be sequestered by the mitochondrion. This may assure that incomplete TCR forms would not interfere with correct TCR complex formation. ..
  51. Cao X, Wa Q, Wang Q, Li L, Liu X, An L, et al. High throughput sequencing reveals the diversity of TRB-CDR3 repertoire in patients with psoriasis vulgaris. Int Immunopharmacol. 2016;40:487-491 pubmed publisher
    ..this, we performed high-throughput sequencing to reveal the immunological characteristics of TCR beta chain (TRB) in both psoriasis patients and healthy controls...
  52. Grossman I, Avidan N, Singer C, Goldstaub D, Hayardeny L, Eyal E, et al. Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis reveals drug-response markers. Pharmacogenet Genomics. 2007;17:657-66 pubmed
    ..association between glatiramer acetate response and a single nucleotide polymorphism in a T-cell receptor beta (TRB@) variant replicated in the two independent cohorts (odds ratio=6.85). Findings in the Cathepsin S (CTSS) gene (P=0...
  53. Leet J, Sassman S, Amberg J, Olmstead A, Lee L, Ankley G, et al. Environmental hormones and their impacts on sex differentiation in fathead minnows. Aquat Toxicol. 2015;158:98-107 pubmed
    ..used to expose larvae during the period of 10-20 days post-hatch (dph) to either 5 ng/L 17β-trenbolone (17β-TRB) or 5 ng/L 17α-ethinylestradiol (EE2)...
  54. Fulton J, Mazumder B, Whitchurch J, Monteiro C, Collins H, Chan C, et al. Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations. Cell Death Dis. 2017;8:e2677 pubmed publisher
    ..with the LBDs of peroxisome proliferator-activated receptor-γ (PPARγ)/NR1C3 and thyroid hormone receptor b (TRb) TRβ/NR1A2...
  55. Nakajima J, Matsumoto J, Takeuchi E, Fukami T, Takamoto S. Rearrangement of T-cell receptor beta and gamma genes in thymoma. Asian Cardiovasc Thorac Ann. 2005;13:149-52 pubmed
    ..In conclusion, thymomas have the capability of T-lineage cell differentiation, except for a subset of invasive thymomas with malignant characteristics. ..
  56. Diluvio L, Vollmer S, Besgen P, Ellwart J, Chimenti S, Prinz J. Identical TCR beta-chain rearrangements in streptococcal angina and skin lesions of patients with psoriasis vulgaris. J Immunol. 2006;176:7104-11 pubmed
  57. Emi M, Nakamura Y, Ogawa M, Yamamoto T, Nishide T, Mori T, et al. Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. Gene. 1986;41:305-10 pubmed
    ..Southern blot analysis of human genomic DNA using the cloned cDNA as a probe, revealed that the human trypsinogen genes constitute a multigene family of more than ten genes. ..
  58. Lawson C, Donaldson I, Bowman S, Shefta J, Morgan A, Gough A, et al. Analysis of the insertion/deletion related polymorphism within T cell antigen receptor beta variable genes in primary Sjögren's syndrome. Ann Rheum Dis. 2005;64:468-70 pubmed
    ..Eighty nine per cent of PSS patients have at least one extra germline copy of BV13S2*1. This may relate to previous observations of increased BV13 specific T cells and mRNA in the salivary glands. ..
  59. Huang J, Xi J, Hu H, Li Y, Lu S, Tang F, et al. UV light tolerance and reactivation potential of tetracycline-resistant bacteria from secondary effluents of a wastewater treatment plant. J Environ Sci (China). 2016;41:146-153 pubmed publisher
    ..The inactivation ratio of TRB was significantly lower (3.0-log) than that of heterotrophic bacteria (>4.0-log) in the secondary effluent...
  60. Kitaura K, Shini T, Matsutani T, Suzuki R. A new high-throughput sequencing method for determining diversity and similarity of T cell receptor (TCR) ? and ? repertoires and identifying potential new invariant TCR ? chains. BMC Immunol. 2016;17:38 pubmed
    ..similarity of expressed TCR repertoires among individuals, we conducted next-generation sequencing (NGS) of TRA and TRB genes in peripheral blood mononuclear cells from 20 healthy human individuals...
  61. Pirovano S, Notarangelo L, Valotti M, Ugazio A, Albertini A, Imberti L. Mutations of the T-cell receptor constant region after in utero stem cell transplantation. Immunogenetics. 2004;56:214-9 pubmed
    ..These results provide further support indicating that hypermutation of the T-cell receptor genes may indeed occur, given the necessary conditions. ..
  62. Touma M, Chang H, Sasada T, Handley M, Clayton L, Reinherz E. The TCR C beta FG loop regulates alpha beta T cell development. J Immunol. 2006;176:6812-23 pubmed
    ..Collectively, our results show that the unique Cbeta FG loop appendage primarily controls alphabeta T cell development through selection processes. ..
  63. Orlando L, Accomasso L, Circosta P, Turinetto V, Lantelme E, Porcedda P, et al. TCR transfer induces TCR-mediated tonic inhibition of RAG genes in human T cells. Mol Immunol. 2011;48:1369-76 pubmed publisher
    ..Lastly, we show that the TCR constructs employed in TCR gene therapy do not possess the same basal signaling transduction capability, a feature that may have therapeutic implications. ..
  64. Molnar E, Swamy M, Holzer M, Beck García K, Worch R, Thiele C, et al. Cholesterol and sphingomyelin drive ligand-independent T-cell antigen receptor nanoclustering. J Biol Chem. 2012;287:42664-74 pubmed publisher
    ..Our work contributes to the understanding of the function of specific nonannular lipid-membrane protein interactions. ..
  65. Mahmoudi S, Zaini F, Kordbacheh P, Safara M, Heidari M. Sporothrix schenckii complex in Iran: Molecular identification and antifungal susceptibility. Med Mycol. 2016;54:593-9 pubmed publisher
    ..There was significant agreement (73%) between the results of the phenotypic and genotypic identification methods. TRB and ITC were the most effective antifungals against the Sporothrix isolates...
  66. Xu L, You X, Zheng P, Zhang B, Gupta P, Lavori P, et al. Methodologic Considerations in the Application of Next-Generation Sequencing of Human TRB Repertoires for Clinical Use. J Mol Diagn. 2017;19:72-83 pubmed publisher
    ..Higher variability was observed in sequencing of different TRB libraries made from the same DNA stock...
  67. Yoshikai Y, Anatoniou D, Clark S, Yanagi Y, Sangster R, van den Elsen P, et al. Sequence and expression of transcripts of the human T-cell receptor beta-chain genes. Nature. 1984;312:521-4 pubmed
    ..A 1.0-kb mRNA, found mainly in immature T cells, does not contain V sequences and can result from transcription that initiates upstream from an unrearranged J element. ..
  68. Gao F, Wang K. Ligation-anchored PCR unveils immune repertoire of TCR-beta from whole blood. BMC Biotechnol. 2015;15:39 pubmed publisher
    ..Mapping of sequencing data showed that 64% to 96% of mapped TCRV-containing reads belong to TRB subtype. An increased usage of specific V segments and V-J pairing were observed in malignant meningiomas samples...
  69. Sakai S, Miyajima C, Uchida C, Itoh Y, Hayashi H, Inoue Y. Tribbles-Related Protein Family Members as Regulators or Substrates of the Ubiquitin-Proteasome System in Cancer Development. Curr Cancer Drug Targets. 2016;16:147-56 pubmed
    ..Tribbles genes are evolutionary conserved, and three TRB genes (TRB1, TRB2 and TRB3) have been identified in mammals...
  70. Kang Y, Hao Y, Shen M, Zhao Q, Li Q, Hu J. Impacts of supplementing chemical fertilizers with organic fertilizers manufactured using pig manure as a substrate on the spread of tetracycline resistance genes in soil. Ecotoxicol Environ Saf. 2016;130:279-88 pubmed publisher
    ..Composted manures combined with a CF did not significantly increase TRB compared with the CF alone, but PM treatment resulted in the long-term survival of TRB in soil...
  71. Tao C, Shao H, Shen H, Huang S. [Homology modeling and eukaryotic expression of a modified ?? TCR harboring the immunoglobulin-like domain of ?? TCR]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:1026-30 pubmed
    ..CLSM showed that TCR ?Ig was expressed and located at the plasma membrane of Jurkat T cells. Conclusion The design of TCR ?Ig was reasonable and the TCR ?Ig could be expressed on Jurkat T cell surface. ..
  72. Campregher P, Srivastava S, Deeg H, Robins H, Warren E. Abnormalities of the alphabeta T-cell receptor repertoire in advanced myelodysplastic syndrome. Exp Hematol. 2010;38:202-12 pubmed publisher
    ..We have developed a robust analytic algorithm that enables the comparison of alphabeta TCR repertoires between individuals and have shown that abnormal alphabeta TCR repertoire is a feature of a subset of patients with advanced MDS. ..
  73. Rådestad E, Wikell H, Engström M, Watz E, Sundberg B, Thunberg S, et al. Alpha/beta T-cell depleted grafts as an immunological booster to treat graft failure after hematopoietic stem cell transplantation with HLA-matched related and unrelated donors. J Immunol Res. 2014;2014:578741 pubmed publisher
    ..No signs of GVHD or other side effects were detected. A larger pool of patients with longer follow-up time is needed to confirm the data in this study. ..
  74. Sun J, Sun B, Gao Y, He F, Yang L, Wang M, et al. Composition and Variation Analysis of the T Cell Receptor ?-Chain Complementarity Determining Region 3 Repertoire in Neonatal Sepsis. Scand J Immunol. 2017;86:418-423 pubmed publisher
    ..Our data showed the characteristics of the TCR repertoire in neonates with sepsis, which represents a potentially valuable data set. This result is useful for understanding neonatal susceptibility to infection. ..
  75. Mohn F, Buhler M, Mühlemann O. Nonsense-associated alternative splicing of T-cell receptor beta genes: no evidence for frame dependence. RNA. 2005;11:147-56 pubmed
    ..Our study thus contradicts the previously reported PTC specificity of TCR-beta NAS and points out the need for systematically testing the PTC specificity in other cases where NAS has been observed. ..
  76. Heemskerk M, Hagedoorn R, van der Hoorn M, van der Veken L, Hoogeboom M, Kester M, et al. Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex. Blood. 2007;109:235-43 pubmed
    ..In conclusion, introduced, endogenous, and chimeric TCRs compete for cell-surface expression in favor of the TCR-CD3 complex with best-pairing properties. ..
  77. Carrillo Muñoz A, Tur Tur C, Cárdenes D, Rojas F, Giusiano G. [In vitro antifungal susceptibility profile of Scopulariopsis brevicaulis isolated from onychomycosis]. Rev Esp Quimioter. 2015;28:210-3 pubmed
    ..itraconazole (ITZ), ketoconazole (KTZ), miconazole (MNZ), oxiconazole (OXZ), tioconazole (TCZ) and terbinafine (TRB) against 26 clinical isolates of Scopulariopsis brevicaulis from patients with onychomycosis by means of an ..
  78. Qi Q, Liu Y, Cheng Y, Glanville J, Zhang D, Lee J, et al. Diversity and clonal selection in the human T-cell repertoire. Proc Natl Acad Sci U S A. 2014;111:13139-44 pubmed publisher
    ..and nonparametric statistical analysis to estimate a lower bound for the total number of different TCR beta (TCRB) sequences in human repertoires...
  79. Brauer P, Pessach I, Clarke E, Rowe J, Ott de Bruin L, Lee Y, et al. Modeling altered T-cell development with induced pluripotent stem cells from patients with RAG1-dependent immune deficiencies. Blood. 2016;128:783-93 pubmed publisher
    ..with preferential usage of few Variable, Diversity, and Joining genes, and skewed length distribution of the TRB and TRA complementary determining region 3 sequences from SCID and OS iPSC-derived cells, whereas control iPSCs ..
  80. Salcedo D, Kim S. Fate of tetracycline resistance in synthetic livestock carcass leachate for two years. J Environ Manage. 2017;187:220-228 pubmed publisher
    ..Based on the temporal pattern of EC50 during the study period, TRB continuously increased during Phase I (0-250th day), went down in Phase II (after 250th day to 500th day), and then ..
  81. Uebe S, Ehrlicher M, Ekici A, Behrens F, Böhm B, Homuth G, et al. Genome-wide association and targeted analysis of copy number variants with psoriatic arthritis in German patients. BMC Med Genet. 2017;18:92 pubmed publisher alternative quantitative method, two significantly associated CNVs remained, one near UXS1, the other one at the TRB locus...
  82. Sims J, Tunnacliffe A, Smith W, Rabbitts T. Complexity of human T-cell antigen receptor beta-chain constant- and variable-region genes. Nature. 1984;312:541-5 pubmed
    ..The gene arrangement, analogous to that of mouse beta-chain genes, shows strong evolutionary conservation of the dual C beta gene system in these two species. ..
  83. Ishizuka J, Stewart Jones G, van der Merwe A, Bell J, McMichael A, Jones E. The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain. Immunity. 2008;28:171-82 pubmed publisher
    ..The chances of having a substantial number of T cells in the naive repertoire that have HLA-A2-flu-specific Vbeta17 receptors may consequently be relatively high, thus explaining the immunodominant usage of this clonotype. ..
  84. Wu X, Zhu K, Du X, Chen S, Yang L, Wu J, et al. Frequency analysis of TRBV subfamily sjTRECs to characterize T-cell reconstitution in acute leukemia patients after allogeneic hematopoietic stem cell transplantation. J Hematol Oncol. 2011;4:19 pubmed publisher
    ..GVHD could affect reconstitution of thymic output function and reduce sjTRECs levels and frequencies of TRBV-BD1 sjTRECs. Low frequency of BV22-BD1 and BV23-BD1 sjTRECs might be associated with GVHD. ..
  85. Wang X, Wang P, Wang R, Wang C, Bai J, Ke C, et al. Analysis of TCRβ and TCRγ genes in Chinese alligator provides insights into the evolution of TCR genes in jawed vertebrates. Dev Comp Immunol. 2018;85:31-43 pubmed publisher
    ..BAC) library and available genome data, we characterized the genomic organization, evolution and expression of TRB and TRG loci in Alligator sinensis...
  86. Han A, Newell E, Glanville J, Fernandez Becker N, Khosla C, Chien Y, et al. Dietary gluten triggers concomitant activation of CD4+ and CD8+ ?? T cells and ?? T cells in celiac disease. Proc Natl Acad Sci U S A. 2013;110:13073-8 pubmed publisher
    ..More broadly, these responses may parallel adaptive immune responses to viral pathogens and other systemic autoimmune diseases. ..
  87. Homa M, Galgóczy L, Tóth E, Tóth L, Papp T, Chandrasekaran M, et al. In vitro antifungal activity of antipsychotic drugs and their combinations with conventional antifungals against Scedosporium and Pseudallescheria isolates. Med Mycol. 2015;53:890-5 pubmed publisher
    ..e., amphotericin B, AMB; caspofungin, CSP; itraconazole; terbinafine, TRB and voriconazole, VRC) were investigated in broth microdilution tests against four clinical and five environmental ..
  88. Ebert A, Hill L, Busslinger M. Spatial Regulation of V-(D)J Recombination at Antigen Receptor Loci. Adv Immunol. 2015;128:93-121 pubmed publisher
    ..V(D)J recombination takes place in the 3' proximal domain containing the D, J, and C gene segments, whereas 31 (Tcrb) to 200 (Igh) V genes are spread over a large region of 0.67 (Tcrb) to 3 (Igk) megabase pairs...
  89. Fell J, Beirness D, Voas R, Smith G, Jonah B, Maxwell J, et al. Can progress in reducing alcohol-impaired driving fatalities be resumed? Results of a workshop sponsored by the Transportation Research Board, Alcohol, Other Drugs, and Transportation Committee (ANB50). Traffic Inj Prev. 2016;17:771-81 pubmed publisher
    ..The National Academy of Sciences (NAS) Transportation Research Board (TRB), Alcohol, Other Drugs, and Transportation Committee (ANB50) sponsored a workshop held at the NAS facility in Woods ..
  90. Villeneuve D, Jensen K, Cavallin J, Durhan E, Garcia Reyero N, Kahl M, et al. Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17?-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas). Environ Toxicol Chem. 2017;36:231-242 pubmed publisher
    ..Exposure to 1?µg TCC/L had no effect on reproduction. In general, both TRB and MIX treatments caused similar physiological effects, evoking significant reductions in female plasma ..
  91. Yang P, Xia J, Zhan C, Qiao Y, Wang Y. Monitoring the spatio-temporal changes of terrestrial water storage using GRACE data in the Tarim River basin between 2002 and 2015. Sci Total Environ. 2017;595:218-228 pubmed publisher
    ..and Climate Experiment (GRACE) and Global Land Data Assimilation System (GLDAS) to monitor TWS variation in the TRB during the period of 2002-2015, cooperating with two statistical techniques, Principal Component Analysis (PCA) - ..
  92. Zuleger C, Macklin M, Bostwick B, Pei Q, Newton M, Albertini M. In vivo 6-thioguanine-resistant T cells from melanoma patients have public TCR and share TCR beta amino acid sequences with melanoma-reactive T cells. J Immunol Methods. 2011;365:76-86 pubmed publisher
    ..Public TRB were identified in MT from the blood and tumor of different melanoma patients...