transthyretin

Summary

Gene Symbol: transthyretin
Description: transthyretin
Alias: ATTR, CTS, CTS1, HEL111, HsT2651, PALB, TBPA, transthyretin, epididymis luminal protein 111, prealbumin, amyloidosis type I, thyroxine-binding prealbumin
Species: human
Products:     transthyretin

Top Publications

  1. Monaco H, Rizzi M, Coda A. Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein. Science. 1995;268:1039-41 pubmed
    The three-dimensional structure of the complex formed by two plasma proteins, transthyretin and retinol-binding protein, was determined from x-ray diffraction data to a nominal resolution of 3.1 angstroms...
  2. Murakami T, Atsumi T, Maeda S, Tanase S, Ishikawa K, Mita S, et al. A novel transthyretin mutation at position 30 (Leu for Val) associated with familial amyloidotic polyneuropathy. Biochem Biophys Res Commun. 1992;187:397-403 pubmed
    A novel transthyretin (TTR) mutation associated with familial amyloidotic polyneuropathy was detected in a Japanese patient...
  3. Westermark P, Sletten K, Johansson B, Cornwell G. Fibril in senile systemic amyloidosis is derived from normal transthyretin. Proc Natl Acad Sci U S A. 1990;87:2843-5 pubmed
    ..fibril in senile systemic amyloidosis (SSA), like that of familial amyloidotic polyneuropathy, is derived from transthyretin (TTR)...
  4. Zhang H, Zhang X, Mao X, Deng H, Li H, Press R, et al. Altered cerebrospinal fluid index of prealbumin, fibrinogen, and haptoglobin in patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy. Acta Neurol Scand. 2012;125:129-35 pubmed publisher
    ..Further studies are needed to identify the underlying mechanisms behind these CSF protein alterations and to clarify whether prealbumin, fibrinogen, and haptoglobin can serve as useful biomarkers for GBS and CIDP. ..
  5. Hornstrup L, Frikke Schmidt R, Nordestgaard B, Tybjærg Hansen A. Genetic stabilization of transthyretin, cerebrovascular disease, and life expectancy. Arterioscler Thromb Vasc Biol. 2013;33:1441-7 pubmed publisher
    b>Transthyretin can cause amyloidosis attributable to destabilization of transthyretin tetramers in plasma...
  6. Cuenco K, FRIEDLAND R, Baldwin C, Guo J, Vardarajan B, Lunetta K, et al. Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families. Neurobiol Aging. 2011;32:249-56 pubmed publisher
    In vitro and animal model studies suggest that transthyretin (TTR) inhibits the production of the amyloid ? protein, a major contributor to Alzheimer disease (AD) pathogenesis...
  7. Sato T, Susuki S, Suico M, Miyata M, Ando Y, Mizuguchi M, et al. Endoplasmic reticulum quality control regulates the fate of transthyretin variants in the cell. EMBO J. 2007;26:2501-12 pubmed
    The secretion of transthyretin (TTR) variants contributes to the pathogenesis of amyloidosis because they form aggregates in the extracellular environment...
  8. Ferrão Gonzales A, Souto S, Silva J, Foguel D. The preaggregated state of an amyloidogenic protein: hydrostatic pressure converts native transthyretin into the amyloidogenic state. Proc Natl Acad Sci U S A. 2000;97:6445-50 pubmed
    ..Here, the properties and formation of amyloidogenic intermediates of transthyretin (TTR) were investigated by the use of hydrostatic pressure and spectroscopic techniques...
  9. Xie Y, Zhao Y, Zhou J, Wang X. [Identification of a TTR gene mutation in a family with hereditary vitreous amyloidosis]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012;29:13-5 pubmed publisher
    ..Genomic DNA was extracted from peripheral blood sample and subjected to amplification of 4 exons of transthyretin (TTR) gene. The PCR products were purified and subjected to direct sequencing...

More Information

Publications75

  1. Hellman U, Alarcon F, Lundgren H, Suhr O, Bonaïti Pellié C, Plante Bordeneuve V. Heterogeneity of penetrance in familial amyloid polyneuropathy, ATTR Val30Met, in the Swedish population. Amyloid. 2008;15:181-6 pubmed publisher
    b>Transthyretin (TTR) familial amyloid polyneuropathies (FAP) are autosomal dominant devastating afflictions. They were first described in Portugal, later in Japan and Sweden and are now recognized worldwide...
  2. Myron Johnson A, Merlini G, Sheldon J, Ichihara K. Clinical indications for plasma protein assays: transthyretin (prealbumin) in inflammation and malnutrition. Clin Chem Lab Med. 2007;45:419-26 pubmed
    A large number of circumstances are associated with reduced serum concentrations of transthyretin (TTR), or prealbumin...
  3. Hammarstrom P, Wiseman R, Powers E, Kelly J. Prevention of transthyretin amyloid disease by changing protein misfolding energetics. Science. 2003;299:713-6 pubmed
    ..Here, we describe a series of transthyretin amyloidosis inhibitors that functioned by increasing the kinetic barrier associated with misfolding, ..
  4. Liu J, Guo Y, Zhou C, Ye Y, Feng J, Yin F, et al. Clinical and histopathological features of familial amyloidotic polyneuropathy with transthyretin Val30Ala in a Chinese family. J Neurol Sci. 2011;304:83-6 pubmed publisher
    ..FAP) is characterized by extracellular deposition of amyloid fibrils caused by a point mutation in the transthyretin (TTR) gene...
  5. Holmgren G, Hellman U, Lundgren H, Sandgren O, Suhr O. Impact of homozygosity for an amyloidogenic transthyretin mutation on phenotype and long term outcome. J Med Genet. 2005;42:953-6 pubmed
    Although amyloidogenic transthyretin (ATTR) mutations are common in several populations, such as black Americans, the small number of diagnosed patients homozygous for TTR amyloid and the short follow up in most studies has until now ..
  6. Matsubara K, Mizuguchi M, Igarashi K, Shinohara Y, Takeuchi M, Matsuura A, et al. Dimeric transthyretin variant assembles into spherical neurotoxins. Biochemistry. 2005;44:3280-8 pubmed
    Familial amyloidotic polyneuropathy is a hereditary autosomal-dominant disease in which the deposited transthyretin fibrils are derived from amyloidogenic mutation...
  7. Olofsson A, Ippel J, Wijmenga S, Lundgren E, Ohman A. Probing solvent accessibility of transthyretin amyloid by solution NMR spectroscopy. J Biol Chem. 2004;279:5699-707 pubmed
    The human plasma protein transthyretin (TTR) may form fibrillar protein deposits that are associated with both inherited and idiopathic amyloidosis...
  8. Velayudhan L, Killick R, Hye A, Kinsey A, Güntert A, Lynham S, et al. Plasma transthyretin as a candidate marker for Alzheimer's disease. J Alzheimers Dis. 2012;28:369-75 pubmed publisher
    ..Among these, one of the most interesting candidates is transthyretin (TTR), the carrier of thyroxine and retinol, which also binds with amyloid-? (A?), and it has been suggested ..
  9. Natunen T, Helisalmi S, Vepsäläinen S, Sarajärvi T, Antikainen L, Mäkinen P, et al. Genetic analysis of genes involved in amyloid-? degradation and clearance in Alzheimer's disease. J Alzheimers Dis. 2012;28:553-9 pubmed publisher
    ..age of onset was observed in AD patients carrying the A allele of rs723744 and the C allele of rs3794884 in transthyretin (TTR) gene...
  10. Saraiva M. Transthyretin mutations in health and disease. Hum Mutat. 1995;5:191-6 pubmed
    To date, over 40 different mutations in transthyretin (TTR) have been associated with amyloid deposition. The major unresolved problem is the correlation between the clinical heterogeneity and the genetic heterogeneity...
  11. Grus F, Joachim S, Sandmann S, Thiel U, Bruns K, Lackner K, et al. Transthyretin and complex protein pattern in aqueous humor of patients with primary open-angle glaucoma. Mol Vis. 2008;14:1437-45 pubmed
    ..006), was identified as transthyretin. The upregulation of transthyretin in POAG patients was also confirmed by enzyme linked immunosorbent assay (..
  12. Tsuzuki T, Mita S, Maeda S, Araki S, Shimada K. Structure of the human prealbumin gene. J Biol Chem. 1985;260:12224-7 pubmed
    ..Unexpectedly, two independent open reading frames provided with respective regulatory sequences were found within the gene: one in the first intron and the other in the third intron. ..
  13. Han S, Jung E, Sohn J, Hong H, Hong H, Kim J, et al. Human serum transthyretin levels correlate inversely with Alzheimer's disease. J Alzheimers Dis. 2011;25:77-84 pubmed publisher
    ..constitutes the epicenter of AD pathology, A?-binding proteins that regulate A? aggregation, such as transthyretin (TTR), have attracted much attention...
  14. Zaros C, Genin E, Hellman U, Saporta M, Languille L, Wadington Cruz M, et al. On the origin of the transthyretin Val30Met familial amyloid polyneuropathy. Ann Hum Genet. 2008;72:478-84 pubmed publisher
    b>Transthyretin (TTR) familial amyloid polyneuropathy is a severe autosomal dominant neuropathy of adulthood, frequently linked to the pathogenic Val30Met variant of the TTR gene...
  15. Soares M, Coelho T, Sousa A, Batalov S, Conceição I, Sales Luís M, et al. Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease. Hum Mol Genet. 2005;14:543-53 pubmed
    Familial amyloid polyneuropathy type I is an autosomal dominant disorder caused by mutations in the transthyretin (TTR) gene; however, carriers of the same mutation exhibit variability in penetrance and clinical expression...
  16. Soares M, Coelho T, Sousa A, Holmgren G, Saraiva M, Kastner D, et al. Haplotypes and DNA sequence variation within and surrounding the transthyretin gene: genotype-phenotype correlations in familial amyloid polyneuropathy (V30M) in Portugal and Sweden. Eur J Hum Genet. 2004;12:225-37 pubmed
    ..polyneuropathy (FAP) is a lethal autosomal dominant disorder in which fibrils derived from mutant forms of transthyretin (TTR), the normal plasma carrier of thyroxine (T(4)) and retinol-binding protein, are deposited in tissues...
  17. Saraiva M, Costa P, Birken S, Goodman D. Presence of an abnormal transthyretin (prealbumin) in Portuguese patients with familial amyloidotic polyneuropathy. Trans Assoc Am Physicians. 1983;96:261-70 pubmed
    ..Based on these observations, we postulate that this abnormal form of TTR selectively deposits in tissues as the amyloid characteristic of the disease. ..
  18. Noborn F, O Callaghan P, Hermansson E, Zhang X, Ancsin J, Damas A, et al. Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein. Proc Natl Acad Sci U S A. 2011;108:5584-9 pubmed publisher
    b>Transthyretin (TTR) is a homotetrameric protein that transports thyroxine and retinol...
  19. Li X, Masliah E, Reixach N, Buxbaum J. Neuronal production of transthyretin in human and murine Alzheimer's disease: is it protective?. J Neurosci. 2011;31:12483-90 pubmed publisher
    b>Transthyretin (TTR), a systemic amyloid precursor in the human TTR amyloidoses, interacts with ?-amyloid (A?) in vitro, inhibits A? fibril formation, and suppresses the Alzheimer's disease (AD) phenotype in APP23 mice bearing a human APP ..
  20. Sato T, Sako Y, Sho M, Momohara M, Suico M, Shuto T, et al. STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. Mol Cell. 2012;47:99-110 pubmed publisher
    ..the cryptic N-glycosylation site as a recognition signal for unfolding of a natively nonglycosylated protein, transthyretin (TTR), involved in familial amyloidosis...
  21. Olsson M, Norgren N, Obayashi K, Plante Bordeneuve V, Suhr O, Cederquist K, et al. A possible role for miRNA silencing in disease phenotype variation in Swedish transthyretin V30M carriers. BMC Med Genet. 2010;11:130 pubmed publisher
    Familial amyloidosis with polyneuropathy (FAP) is an autosomal dominant disease caused by transthyretin (TTR) mutations, of which V30M (TTR c.148G > A, p.Val50Met, "Val30Met") is the most common...
  22. Lovell M, Lynn B, Xiong S, Quinn J, Kaye J, Markesbery W. An aberrant protein complex in CSF as a biomarker of Alzheimer disease. Neurology. 2008;70:2212-8 pubmed publisher
    To determine if an aberrant protein complex consisting of prostaglandin-d-synthase (PDS) and transthyretin (TTR) in CSF differentiates between subjects with Alzheimer disease (AD) and normal control (NC) subjects...
  23. Jaroniec C, MacPhee C, Astrof N, Dobson C, Griffin R. Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril. Proc Natl Acad Sci U S A. 2002;99:16748-53 pubmed
    The molecular conformation of peptide fragment 105-115 of transthyretin, TTR(105-115), previously shown to form amyloid fibrils in vitro, has been determined by magic-angle spinning solid-state NMR spectroscopy...
  24. Hammarstrom P, Schneider F, Kelly J. Trans-suppression of misfolding in an amyloid disease. Science. 2001;293:2459-62 pubmed
    The transthyretin (TTR) amyloid diseases, representative of numerous misfolding disorders, are of considerable interest because there are mutations that cause or suppress disease...
  25. Maleknia S, Reixach N, Buxbaum J. Oxidation inhibits amyloid fibril formation of transthyretin. FEBS J. 2006;273:5400-6 pubmed
    ..b>Transthyretin (TTR) is a soluble human plasma protein...
  26. Li Y, Ng H, Sun I, Leong W. Clinical and genetic analysis of three families with familiar amyloid polyneuropathy. Chin Med Sci J. 2008;23:230-3 pubmed
    ..To study the clinical and genetic features of familiar amyloid polyneuropathy (FAP)...
  27. Gustavsson A, Jahr H, Tobiassen R, Jacobson D, Sletten K, Westermark P. Amyloid fibril composition and transthyretin gene structure in senile systemic amyloidosis. Lab Invest. 1995;73:703-8 pubmed
    In many different forms of amyloidosis, transthyretin (TTR) comprises the major amyloid fibril protein. In the familial forms, various TTR mutations are linked to disease...
  28. Chiang H, Lyu R, Tseng M, Chang K, Chang H, Hsu W, et al. Analyses of transthyretin concentration in the cerebrospinal fluid of patients with Guillain-Barré syndrome and other neurological disorders. Clin Chim Acta. 2009;405:143-7 pubmed publisher
    ..Previously, using two-dimensional gel electrophoresis and mass spectrometry, we found that the transthyretin level was altered in the cerebrospinal fluid (CSF) of GBS patients when compared to that in CSF of control ..
  29. Buxbaum J, Anan I, Suhr O. Serum transthyretin levels in Swedish TTR V30M carriers. Amyloid. 2010;17:83-5 pubmed publisher
    Serum transthyretin (TTR) levels have been reported to be reduced in Portuguese and Japanese patients with TTR V30M familial amyloidotic polyneuropathy and pre-symptomatic carriers of the allele as well as in the carriers of a number of ..
  30. Blake C, Geisow M, Oatley S, Rerat B, Rerat C. Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A. J Mol Biol. 1978;121:339-56 pubmed
  31. Du J, Cho P, Yang D, Murphy R. Identification of beta-amyloid-binding sites on transthyretin. Protein Eng Des Sel. 2012;25:337-45 pubmed publisher
    b>Transthyretin (TTR) binds to the Alzheimer-related peptide beta-amyloid (A?), and may protect against A?-induced neurotoxicity. In this work, the specific domains on TTR involved with binding to A? were probed...
  32. Zhang Y, Deng Y, Ma J, Zheng L, Hong Z, Wang Z, et al. Transthyretin-related hereditary amyloidosis in a Chinese family with TTR Y114C mutation. Neurodegener Dis. 2011;8:187-93 pubmed publisher
    b>Transthyretin-related hereditary amyloidosis is an autosomal dominant inherited disease caused by mutations in the transthyretin (TTR) gene...
  33. Ruano D, Macedo A, Soares M, Valente J, Azevedo M, Hutz M, et al. Transthyretin: no association between serum levels or gene variants and schizophrenia. J Psychiatr Res. 2007;41:667-72 pubmed
    ..Among these is transthyretin (TTR), a major carrier of thyroid hormones and retinol-binding protein (RBP)...
  34. Shi Y, Li J, Hu J, Hu J, Sun L, Li H, et al. A new Arg54Gly transthyretin gene mutation associated with vitreous amyloidosis in Chinese. Eye Sci. 2011;26:230-8 pubmed publisher
    ..Province, China, and to investigate the correlation between the clinical appearance of the disease and transthyretin (TTR) gene mutation, including the locus and type of TTR gene mutation...
  35. Reixach N, Deechongkit S, Jiang X, Kelly J, Buxbaum J. Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture. Proc Natl Acad Sci U S A. 2004;101:2817-22 pubmed
    The transthyretin (TTR) amyloidoses are human diseases in which the misfolded TTR protein aggregates in tissues with subsequent visceral, peripheral, and autonomic nerve dysfunction...
  36. Palaninathan S, Mohamedmohaideen N, Snee W, Kelly J, Sacchettini J. Structural insight into pH-induced conformational changes within the native human transthyretin tetramer. J Mol Biol. 2008;382:1157-67 pubmed publisher
    Acidification of the transthyretin (TTR) tetramer facilitates dissociation and conformational changes in the protein, allowing alternatively folded monomers to self-assemble into insoluble amyloid fibers by a downhill polymerization ..
  37. Ribeiro Silva C, Gilberto S, Gomes R, Mateus E, Monteiro E, Barroso E, et al. The relative amounts of plasma transthyretin forms in familial transthyretin amyloidosis: a quantitative analysis by Fourier transform ion-cyclotron resonance mass spectrometry. Amyloid. 2011;18:191-9 pubmed publisher
    Familial transthyretin amyloidosis (ATTR) is a fatal autosomal dominant disease characterized by the formation of amyloid fibers, mainly composed of transthyretin (TTR)...
  38. Buxbaum J, Tagoe C, Gallo G, Walker J, Kurian S, Salomon D. Why are some amyloidoses systemic? Does hepatic "chaperoning at a distance" prevent cardiac deposition in a transgenic model of human senile systemic (transthyretin) amyloidosis?. FASEB J. 2012;26:2283-93 pubmed publisher
    In the human systemic amyloidoses caused by mutant or wild-type transthyretin (TTR), deposition occurs at a distance from the site of synthesis...
  39. Keetch C, Bromley E, McCammon M, Wang N, Christodoulou J, Robinson C. L55P transthyretin accelerates subunit exchange and leads to rapid formation of hybrid tetramers. J Biol Chem. 2005;280:41667-74 pubmed
    b>Transthyretin is a tetrameric protein associated with the commonest form of systemic amyloid disease...
  40. Long D, Zeng J, Wu L, Tang L, Wang H, Wang H. Vitreous amyloidosis in two large mainland Chinese kindreds resulting from transthyretin variant Lys35Thr and Leu55Arg. Ophthalmic Genet. 2012;33:28-33 pubmed publisher
    To describe the clinical and pathological findings of two large mainland Chinese kindreds with vitreous amyloidosis and associated transthyretin mutation.
  41. Ganapathi M, Jones W, Sehouli J, Michener C, Braicu I, Norris E, et al. Expression profile of COL2A1 and the pseudogene SLC6A10P predicts tumor recurrence in high-grade serous ovarian cancer. Int J Cancer. 2016;138:679-88 pubmed publisher
    ..Thus, evaluating expression levels of COL2A1 and SLC6A10P at primary surgery could be beneficial for clinically managing recurrence of HGSOC. ..
  42. Sawicka Powierza J, Buczkowski K, Chlabicz S, Gugnowski Z, Powierza K, Ołtarzewska A. Quality control of oral anticoagulation with vitamin K antagonists in primary care patients in Poland: a multi-centre study. Kardiol Pol. 2018;76:764-769 pubmed publisher
  43. Kılıç S, Soner Kemal H, Yüce E, Simsek E, Yağmur B, Memişoğlu Akgül N, et al. Comparison of Warfarin use in terms of efficacy and safety in two different polyclinics. Anatol J Cardiol. 2017;18:328-333 pubmed publisher
    ..The findings of our study demonstrate that patients followed in INR-C had higher TTR levels and lower bleeding and ischemic events rates that those followed in General-C. ..
  44. Hellyer J, Azarbal F, Than C, Fan J, Schmitt S, Yang F, et al. Impact of Baseline Stroke Risk and Bleeding Risk on Warfarin International Normalized Ratio Control in Atrial Fibrillation (from the TREAT-AF Study). Am J Cardiol. 2017;119:268-274 pubmed publisher
    ..These findings may paradoxically limit warfarin's efficacy and safety in high-risk patients and may explain observed increased bleeding and stroke rates in this cohort. ..
  45. Demelo Rodríguez P, Postigo Esteban A, García Fernández Bravo I, Agud M, Calpena S, Camacho M, et al. Evaluation of the SAMe-TT2R2 score to predict the quality of anticoagulation control in a cohort of patients with venous thromboembolism treated with vitamin K antagonists. Thromb Res. 2016;147:58-60 pubmed publisher
    ..1% vs 21.2±21.3%, p=0.605) or below (3.9±14% vs 2.9±15.9%, p=0.517) the therapeutic range. The SAMe-TT2R2 score is not useful to predict quality of anticoagulation control in patients with VTE treated with VKA. ..
  46. Kerridge C, Belyaev N, Nalivaeva N, Turner A. The A?-clearance protein transthyretin, like neprilysin, is epigenetically regulated by the amyloid precursor protein intracellular domain. J Neurochem. 2014;130:419-31 pubmed publisher
    ..We now show that the A?-clearance protein transthyretin (TTR) is also epigenetically up-regulated by AICD...
  47. Zhang N, Bi S. Effects of physical exercise on food intake and body weight: Role of dorsomedial hypothalamic signaling. Physiol Behav. 2018;192:59-63 pubmed publisher
    ..Running activity modulates corticotrophin-releasing factor (CRF), neuropeptide Y (NPY) and transthyretin (TTR) signals in the dorsomedial hypothalamus (DMH)...
  48. Chan M, Chang M, González R, Lategan B, del Barco E, Vera Badillo F, et al. Outcomes of Estrogen Receptor Negative and Progesterone Receptor Positive Breast Cancer. PLoS ONE. 2015;10:e0132449 pubmed publisher
    ..Risk of relapse and death more closely resembles ER+ than ER-/PgR- tumors suggesting this phenotype represents a group of more aggressive hormone receptor positive tumors. ..
  49. Riquelme N, Díaz Páez H, Ortiz J. Thermal tolerance in the Andean toad Rhinella spinulosa (Anura: Bufonidae) at three sites located along a latitudinal gradient in Chile. J Therm Biol. 2016;60:237-45 pubmed publisher
    ..The level of plasticity in critical temperatures seems ecologically relevant and supports the acclimatization of thermal limits as an important factor for ectothermic animals to adapt to climate change. ..
  50. Dungu J, Sattianayagam P, Whelan C, Gibbs S, Pinney J, Banypersad S, et al. The electrocardiographic features associated with cardiac amyloidosis of variant transthyretin isoleucine 122 type in Afro-Caribbean patients. Am Heart J. 2012;164:72-9 pubmed publisher
    About 4% of African Americans possess the isoleucine 122 (V122I) variant of transthyretin, associated with cardiac amyloidosis beyond ages of 55 to 60 years...
  51. Tasaki M, Ueda M, Obayashi K, Koike H, Kitagawa K, Ogi Y, et al. Effect of age and sex differences on wild-type transthyretin amyloid formation in familial amyloidotic polyneuropathy: a proteomic approach. Int J Cardiol. 2013;170:69-74 pubmed publisher
    ..sex differences are closely related to the onset of senile systemic amyloidosis (SSA) caused by wild-type (WT) transthyretin (TTR)...
  52. Jianjie C, Wenjuan X, Jinling C, Jie S, Ruhui J, Meiyan L. Fluoride caused thyroid endocrine disruption in male zebrafish (Danio rerio). Aquat Toxicol. 2016;171:48-58 pubmed publisher
    ..were found in the mRNA of iodothyronineⅡ (DIO2), UDP glucuronosyltransferase 1 family a, b (UGT1ab), transthyretin (TTR), and thyroid hormone receptor beta (TRβ)...
  53. Koike H, Tanaka F, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, et al. Natural history of transthyretin Val30Met familial amyloid polyneuropathy: analysis of late-onset cases from non-endemic areas. J Neurol Neurosurg Psychiatry. 2012;83:152-8 pubmed publisher
    The objective of this study was to elucidate the natural history of late-onset transthyretin Val30Met-associated familial amyloid polyneuropathy (FAP ATTR Val30Met) in non-endemic areas...
  54. Leusch F, Aneck Hahn N, Cavanagh J, Du Pasquier D, Hamers T, Hebert A, et al. Comparison of in vitro and in vivo bioassays to measure thyroid hormone disrupting activity in water extracts. Chemosphere. 2018;191:868-875 pubmed publisher
    ..The thyroperoxidase (TPO) inhibition assay and transthyretin (TTR) displacement assay (FITC) detected activity in the surface water and treated wastewater samples, but ..
  55. Sousa M, Norden A, Jacobsen C, Willnow T, Christensen E, Thakker R, et al. Evidence for the role of megalin in renal uptake of transthyretin. J Biol Chem. 2000;275:38176-81 pubmed
    ..In the plasma, one of the T(4) carriers is transthyretin (TTR)...
  56. Hartman V, Castillo Pelayo T, Babinszky S, Dee S, LeBlanc J, Matzke L, et al. Is Your Biobank Up to Standards? A Review of the National Canadian Tissue Repository Network Required Operational Practice Standards and the Controlled Documents of a Certified Biobank. Biopreserv Biobank. 2017;: pubmed publisher
    ..Reviewing documentation is an essential aspect of keeping up to date with best practices and ensuring the quality of biospecimens and data managed by biobanks...
  57. Polimanti R, Di Girolamo M, Manfellotto D, Fuciarelli M. In silico analysis of TTR gene (coding and non-coding regions, and interactive network) and its implications in transthyretin-related amyloidosis. Amyloid. 2014;21:154-62 pubmed publisher
    b>Transthyretin (TTR)-related amyloidosis is a life-threatening disease. Currently, several questions about the pathogenic mechanisms of TTR-related amyloidosis remain unanswered...
  58. Durmuş Tekçe H, Matur Z, Mert Atmaca M, Poda M, Çakar A, Hıdır Ulaş Ü, et al. Genotypic and phenotypic presentation of transthyretin-related familial amyloid polyneuropathy (TTR-FAP) in Turkey. Neuromuscul Disord. 2016;26:441-6 pubmed publisher
    b>Transthyretin-related familial amyloid polyneuropathy (TTR-FAP) is an autosomal dominant disorder caused by mutations of the transthyretin (TTR) gene...
  59. Sikora J, Logue M, Chan G, Spencer B, Prokaeva T, Baldwin C, et al. Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt). Hum Genet. 2015;134:111-21 pubmed publisher
    Wild-type transthyretin amyloidosis (ATTRwt), typically diagnosed as congestive heart failure in elderly Caucasian men, features myocardial amyloid deposits of wild-type plasma protein transthyretin (TTR)...
  60. Solovyov K, Gasteva A, Egorov V, Aleinikova T, Sirotkin A, Shvartsman A, et al. Role of the C-terminal fragment of human transthyretin in abnormal fibrillogenesis. Biochemistry (Mosc). 2006;71:543-9 pubmed
    Polypeptide chain fragments of recombinant transthyretin (TTR) with leucine-55 substituted by proline (L55P), which are involved in abnormal fibrillogenesis of this protein, were studied...
  61. Gasperini R, Klaver D, Hou X, Aguilar M, Small D. Mechanisms of transthyretin aggregation and toxicity. Subcell Biochem. 2012;65:211-24 pubmed publisher
    ..One form of amyloidosis is caused by transthyretin (TTR) misfolding and deposition in target tissues...
  62. Maetzler W, Tian Y, Baur S, Gauger T, Odoj B, Schmid B, et al. Serum and cerebrospinal fluid levels of transthyretin in Lewy body disorders with and without dementia. PLoS ONE. 2012;7:e48042 pubmed publisher
    ..Lowered blood and cerebrospinal fluid (CSF) levels of transthyretin (TTR)--a clearance protein mainly produced in the liver and, autonomously, in the choroid plexus--are ..
  63. Kawaji T, Ando Y, Ando E, Sandgren O, Suhr O, Tanihara H. Transthyretin-related vitreous amyloidosis in different endemic areas. Amyloid. 2010;17:105-8 pubmed publisher
    ..we obtained clinical data for 90 patients with vitreous opacity that was associated with FAP amyloidogenic transthyretin (ATTR) Val30Met; 18 Japanese patients and 72 Swedish patients...
  64. Ingenbleek Y, Young V. Transthyretin (prealbumin) in health and disease: nutritional implications. Annu Rev Nutr. 1994;14:495-533 pubmed
    The name "transthyretin" reflects the dual physiological roles of this tetrameric unglycosylated plasma protein...
  65. Monteiro F, Cardoso I, Sousa M, Saraiva M. In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for advanced glycation end products (RAGE). FEBS Lett. 2006;580:3451-6 pubmed
    ..polyneuropathy is a neurodegenerative disorder characterized by systemic extracellular deposition of transthyretin (TTR) amyloid fibrils...
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