transthyretin

Summary

Gene Symbol: transthyretin
Description: transthyretin
Alias: CTS, CTS1, HEL111, HsT2651, PALB, TBPA, ATTR, carpal tunnel syndrome 1, epididymis luminal protein 111, prealbumin, amyloidosis type I, thyroxine-binding prealbumin
Species: human

Top Publications

  1. ncbi Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein
    H L Monaco
    Department of Genetics, University of Pavia, Italy
    Science 268:1039-41. 1995
  2. pmc A possible role for miRNA silencing in disease phenotype variation in Swedish transthyretin V30M carriers
    Malin Olsson
    Department of Medicine, Umea University, Umea, Sweden
    BMC Med Genet 11:130. 2010
  3. ncbi Plasma transthyretin as a candidate marker for Alzheimer's disease
    Latha Velayudhan
    Department of Old Age Psychiatry, NIHR Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust, London, UK
    J Alzheimers Dis 28:369-75. 2012
  4. pmc Neuronal production of transthyretin in human and murine Alzheimer's disease: is it protective?
    Xinyi Li
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 31:12483-90. 2011
  5. doi Human serum transthyretin levels correlate inversely with Alzheimer's disease
    Sun Ho Han
    Department of Biochemistry and Biomedical Science, Seoul National University, College of Medicine, Seoul, Korea
    J Alzheimers Dis 25:77-84. 2011
  6. doi Analyses of transthyretin concentration in the cerebrospinal fluid of patients with Guillain-Barré syndrome and other neurological disorders
    Han Lin Chiang
    Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Clin Chim Acta 405:143-7. 2009
  7. ncbi DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy
    Shizuyo Koide-Yoshida
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 8589, Japan
    Int J Mol Med 19:885-93. 2007
  8. pmc Heterogeneity of penetrance in familial amyloid polyneuropathy, ATTR Val30Met, in the Swedish population
    Urban Hellman
    Medical and Clinical Genetics, Umea University, Umea, Sweden
    Amyloid 15:181-6. 2008
  9. ncbi Haplotypes and DNA sequence variation within and surrounding the transthyretin gene: genotype-phenotype correlations in familial amyloid polyneuropathy (V30M) in Portugal and Sweden
    Miguel Luz Soares
    Division of Rheumatology Research and the W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Eur J Hum Genet 12:225-37. 2004
  10. ncbi Structure of the human prealbumin gene
    T Tsuzuki
    J Biol Chem 260:12224-7. 1985

Detail Information

Publications197 found, 100 shown here

  1. ncbi Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein
    H L Monaco
    Department of Genetics, University of Pavia, Italy
    Science 268:1039-41. 1995
    The three-dimensional structure of the complex formed by two plasma proteins, transthyretin and retinol-binding protein, was determined from x-ray diffraction data to a nominal resolution of 3.1 angstroms...
  2. pmc A possible role for miRNA silencing in disease phenotype variation in Swedish transthyretin V30M carriers
    Malin Olsson
    Department of Medicine, Umea University, Umea, Sweden
    BMC Med Genet 11:130. 2010
    Familial amyloidosis with polyneuropathy (FAP) is an autosomal dominant disease caused by transthyretin (TTR) mutations, of which V30M (TTR c.148G > A, p.Val50Met, "Val30Met") is the most common...
  3. ncbi Plasma transthyretin as a candidate marker for Alzheimer's disease
    Latha Velayudhan
    Department of Old Age Psychiatry, NIHR Specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust, London, UK
    J Alzheimers Dis 28:369-75. 2012
    ..Among these, one of the most interesting candidates is transthyretin (TTR), the carrier of thyroxine and retinol, which also binds with amyloid-β (Aβ), and it has been suggested ..
  4. pmc Neuronal production of transthyretin in human and murine Alzheimer's disease: is it protective?
    Xinyi Li
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 31:12483-90. 2011
    b>Transthyretin (TTR), a systemic amyloid precursor in the human TTR amyloidoses, interacts with β-amyloid (Aβ) in vitro, inhibits Aβ fibril formation, and suppresses the Alzheimer's disease (AD) phenotype in APP23 mice bearing a human ..
  5. doi Human serum transthyretin levels correlate inversely with Alzheimer's disease
    Sun Ho Han
    Department of Biochemistry and Biomedical Science, Seoul National University, College of Medicine, Seoul, Korea
    J Alzheimers Dis 25:77-84. 2011
    ..constitutes the epicenter of AD pathology, Aβ-binding proteins that regulate Aβ aggregation, such as transthyretin (TTR), have attracted much attention...
  6. doi Analyses of transthyretin concentration in the cerebrospinal fluid of patients with Guillain-Barré syndrome and other neurological disorders
    Han Lin Chiang
    Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Clin Chim Acta 405:143-7. 2009
    ..Previously, using two-dimensional gel electrophoresis and mass spectrometry, we found that the transthyretin level was altered in the cerebrospinal fluid (CSF) of GBS patients when compared to that in CSF of control ..
  7. ncbi DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy
    Shizuyo Koide-Yoshida
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 8589, Japan
    Int J Mol Med 19:885-93. 2007
    ..DJ-1 has a protease-like structure and transthyretin (TTR), a protein causing familial amyloidotic polyneuropathy (FAP), was identified as a substrate for DJ-1 ..
  8. pmc Heterogeneity of penetrance in familial amyloid polyneuropathy, ATTR Val30Met, in the Swedish population
    Urban Hellman
    Medical and Clinical Genetics, Umea University, Umea, Sweden
    Amyloid 15:181-6. 2008
    b>Transthyretin (TTR) familial amyloid polyneuropathies (FAP) are autosomal dominant devastating afflictions. They were first described in Portugal, later in Japan and Sweden and are now recognized worldwide...
  9. ncbi Haplotypes and DNA sequence variation within and surrounding the transthyretin gene: genotype-phenotype correlations in familial amyloid polyneuropathy (V30M) in Portugal and Sweden
    Miguel Luz Soares
    Division of Rheumatology Research and the W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Eur J Hum Genet 12:225-37. 2004
    ..polyneuropathy (FAP) is a lethal autosomal dominant disorder in which fibrils derived from mutant forms of transthyretin (TTR), the normal plasma carrier of thyroxine (T(4)) and retinol-binding protein, are deposited in tissues...
  10. ncbi Structure of the human prealbumin gene
    T Tsuzuki
    J Biol Chem 260:12224-7. 1985
    ..Unexpectedly, two independent open reading frames provided with respective regulatory sequences were found within the gene: one in the first intron and the other in the third intron...
  11. doi Clinical and histopathological features of familial amyloidotic polyneuropathy with transthyretin Val30Ala in a Chinese family
    Jing yao Liu
    Department of Neurology, First Hospital, Jilin University, Changchun, China
    J Neurol Sci 304:83-6. 2011
    ..FAP) is characterized by extracellular deposition of amyloid fibrils caused by a point mutation in the transthyretin (TTR) gene...
  12. doi Transthyretin-related hereditary amyloidosis in a Chinese family with TTR Y114C mutation
    Yu Zhang
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Neurodegener Dis 8:187-93. 2011
    b>Transthyretin-related hereditary amyloidosis is an autosomal dominant inherited disease caused by mutations in the transthyretin (TTR) gene...
  13. ncbi Transthyretin: no association between serum levels or gene variants and schizophrenia
    Dina Ruano
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    J Psychiatr Res 41:667-72. 2007
    ..Among these is transthyretin (TTR), a major carrier of thyroid hormones and retinol-binding protein (RBP)...
  14. pmc Endoplasmic reticulum quality control regulates the fate of transthyretin variants in the cell
    Takashi Sato
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    EMBO J 26:2501-12. 2007
    The secretion of transthyretin (TTR) variants contributes to the pathogenesis of amyloidosis because they form aggregates in the extracellular environment...
  15. pmc Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families
    Karen T Cuenco
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Neurobiol Aging 32:249-56. 2011
    In vitro and animal model studies suggest that transthyretin (TTR) inhibits the production of the amyloid β protein, a major contributor to Alzheimer disease (AD) pathogenesis...
  16. ncbi Vitreous amyloidosis in two large mainland Chinese kindreds resulting from transthyretin variant Lys35Thr and Leu55Arg
    Da Long
    Department of Ophthalmology, The 2nd Xiangya Hospital of Central South University, Changsha, China
    Ophthalmic Genet 33:28-33. 2012
    To describe the clinical and pathological findings of two large mainland Chinese kindreds with vitreous amyloidosis and associated transthyretin mutation.
  17. doi Altered cerebrospinal fluid index of prealbumin, fibrinogen, and haptoglobin in patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy
    H L Zhang
    Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Acta Neurol Scand 125:129-35. 2012
    ..Changes in the CSF levels of proteins other than albumin in patients with GBS and CIDP are not as well studied. If altered, aberrant levels of CSF proteins may render it possible to establish useful biomarkers for GBS and CIDP...
  18. pmc Rabring7 degrades c-Myc through complex formation with MM-1
    Rina Narita
    Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    PLoS ONE 7:e41891. 2012
    ..These results suggest that Rabring7 stimulates c-Myc degradation via mono-ubiquitination of MM-1...
  19. pmc Identification of beta-amyloid-binding sites on transthyretin
    Jiali Du
    Chemical and Biological Engineering Department, University of Wisconsin Madison, Madison, WI 53706, USA
    Protein Eng Des Sel 25:337-45. 2012
    b>Transthyretin (TTR) binds to the Alzheimer-related peptide beta-amyloid (Aβ), and may protect against Aβ-induced neurotoxicity. In this work, the specific domains on TTR involved with binding to Aβ were probed...
  20. doi Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease
    Teemu Natunen
    Institute of Clinical Medicine Neurology, University of Eastern Finland and Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    J Alzheimers Dis 28:553-9. 2012
    ..age of onset was observed in AD patients carrying the A allele of rs723744 and the C allele of rs3794884 in transthyretin (TTR) gene...
  21. doi The relative amounts of plasma transthyretin forms in familial transthyretin amyloidosis: a quantitative analysis by Fourier transform ion-cyclotron resonance mass spectrometry
    Cristina Ribeiro-Silva
    Center of Chemistry and Biochemistry, Department of Chemistry and Biochemistry, Faculty of Sciences University of Lisbon, Campo Grande, Lisbon, Portugal
    Amyloid 18:191-9. 2011
    Familial transthyretin amyloidosis (ATTR) is a fatal autosomal dominant disease characterized by the formation of amyloid fibers, mainly composed of transthyretin (TTR)...
  22. doi [Identification of a TTR gene mutation in a family with hereditary vitreous amyloidosis]
    Yuan Xie
    Laboratory of Molecular Biology, Guiyang Medical University, Guizhou, Guiyang 550004, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:13-5. 2012
    ..To study the disease gene in a family with hereditary vitreous amyloidosis...
  23. ncbi Clinical indications for plasma protein assays: transthyretin (prealbumin) in inflammation and malnutrition
    A Myron Johnson
    Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC 27410, USA
    Clin Chem Lab Med 45:419-26. 2007
    A large number of circumstances are associated with reduced serum concentrations of transthyretin (TTR), or prealbumin...
  24. pmc Fibril in senile systemic amyloidosis is derived from normal transthyretin
    P Westermark
    Department of Pathology, University of Linkoping, Sweden
    Proc Natl Acad Sci U S A 87:2843-5. 1990
    ..fibril in senile systemic amyloidosis (SSA), like that of familial amyloidotic polyneuropathy, is derived from transthyretin (TTR)...
  25. pmc Impact of homozygosity for an amyloidogenic transthyretin mutation on phenotype and long term outcome
    G Holmgren
    J Med Genet 42:953-6. 2005
    Although amyloidogenic transthyretin (ATTR) mutations are common in several populations, such as black Americans, the small number of diagnosed patients homozygous for TTR amyloid and the short follow up in most studies has until now ..
  26. ncbi The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution
    J A Hamilton
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202 5122
    J Biol Chem 268:2416-24. 1993
    The x-ray crystal structures of normal human transthyretin (prealbumin) and the amyloidogenic Val-30-Met variant have been refined at 1.7-A resolution to R-values of 0.168 and 0...
  27. ncbi Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A
    C C Blake
    J Mol Biol 121:339-56. 1978
  28. ncbi Transthyretin mutations in health and disease
    M J Saraiva
    Instituto de Ciencias Biomedicas, Universidade do Porto, Portugal
    Hum Mutat 5:191-6. 1995
    To date, over 40 different mutations in transthyretin (TTR) have been associated with amyloid deposition. The major unresolved problem is the correlation between the clinical heterogeneity and the genetic heterogeneity...
  29. ncbi Dimeric transthyretin variant assembles into spherical neurotoxins
    Kimiaki Matsubara
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Biochemistry 44:3280-8. 2005
    Familial amyloidotic polyneuropathy is a hereditary autosomal-dominant disease in which the deposited transthyretin fibrils are derived from amyloidogenic mutation...
  30. ncbi Amyloid fibril composition and transthyretin gene structure in senile systemic amyloidosis
    A Gustavsson
    Department of Pathology I, Linkoping University, Sweden
    Lab Invest 73:703-8. 1995
    In many different forms of amyloidosis, transthyretin (TTR) comprises the major amyloid fibril protein. In the familial forms, various TTR mutations are linked to disease...
  31. pmc Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture
    Natalia Reixach
    Division of Rheumatology Research, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:2817-22. 2004
    The transthyretin (TTR) amyloidoses are human diseases in which the misfolded TTR protein aggregates in tissues with subsequent visceral, peripheral, and autonomic nerve dysfunction...
  32. ncbi Oxidation inhibits amyloid fibril formation of transthyretin
    Simin D Maleknia
    School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW, Australia
    FEBS J 273:5400-6. 2006
    ..b>Transthyretin (TTR) is a soluble human plasma protein...
  33. ncbi Serum transthyretin levels in Swedish TTR V30M carriers
    Joel Buxbaum
    Department of Molecular and Experimental Medicine, WM Keck Autoimmune Disease Center, The Scripps Research Institute, University of Umea, Umea, Sweden
    Amyloid 17:83-5. 2010
    Serum transthyretin (TTR) levels have been reported to be reduced in Portuguese and Japanese patients with TTR V30M familial amyloidotic polyneuropathy and pre-symptomatic carriers of the allele as well as in the carriers of a number of ..
  34. doi An aberrant protein complex in CSF as a biomarker of Alzheimer disease
    M A Lovell
    Department of Chemistry, Sanders Brown Center on Aging and Alzheimer s Disease Center, University of Kentucky, Lexington, KY 40536 0230, USA
    Neurology 70:2212-8. 2008
    To determine if an aberrant protein complex consisting of prostaglandin-d-synthase (PDS) and transthyretin (TTR) in CSF differentiates between subjects with Alzheimer disease (AD) and normal control (NC) subjects.
  35. ncbi Clinical and genetic analysis of three families with familiar amyloid polyneuropathy
    Yan feng Li
    Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730
    Chin Med Sci J 23:230-3. 2008
    ..To study the clinical and genetic features of familiar amyloid polyneuropathy (FAP)...
  36. doi On the origin of the transthyretin Val30Met familial amyloid polyneuropathy
    C Zaros
    Department of Neurology, Hopital Henri Mondor, 94000 Creteil, France
    Ann Hum Genet 72:478-84. 2008
    b>Transthyretin (TTR) familial amyloid polyneuropathy is a severe autosomal dominant neuropathy of adulthood, frequently linked to the pathogenic Val30Met variant of the TTR gene...
  37. ncbi Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease
    Miguel L Soares
    Department of Molecular and Experimental Medicine, Division of Rheumatology Research and the WM Keck Autoimmune Disease Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Hum Mol Genet 14:543-53. 2005
    Familial amyloid polyneuropathy type I is an autosomal dominant disorder caused by mutations in the transthyretin (TTR) gene; however, carriers of the same mutation exhibit variability in penetrance and clinical expression...
  38. doi [Immune, inflammatory, and nutritional protein profile in children with iron deficiency in Côte d'Ivoire]
    Houphouët Félix Yapi
    Laboratoire de pharmacodynamie biochimique, UFR Biosciences, Université de Cocody Abidjan, Abidjan 22, Cote d Ivoire
    Sante 19:25-8. 2009
    ..05. Iron deficiency was also associated with reduced levels of thyroxine-binding prealbumin (TBPA) and albumin (p < 0.05). Inflammatory proteins did not differ significantly between the two groups (p > 0.05)...
  39. ncbi [The importance of TTR met 30 in the diagnosis of familial amyloidotic polyneuropathy in the absence of a positive family history]
    M Santos
    Unidade de Neurologia e Neurofisiologia, , Portugal
    Rev Neurol 30:929-31. 2000
    ..polyneuropathy type I is an hereditary autosomal dominant disease, characterized by having a mutant transthyretin (TTR met 30)...
  40. doi Recombinant transthyretin purification and competitive binding with organohalogen compounds in two gull species (Larus argentatus and Larus hyperboreus)
    Francisco Ucán-Marin
    National Wildlife Research Centre, Carleton University, Ottawa, Ontario, K1A 0H3, Canada
    Toxicol Sci 107:440-50. 2009
    ..Such compounds can potentially perturb hormone transport via binding interactions with proteins such as transthyretin (TTR, prealbumin)...
  41. ncbi Inhibition of serum protein binding of thyroxine in a hypothyroid patient with familial dysalbuminemic hyperthyroxinemia
    B N Premachandra
    Research Service, Veterans Administration Medical Center, St Louis, MO 63125, USA
    Clin Biochem 29:85-8. 1996
    ..To investigate unusual free thyroxine (FT4) responses to T4 replacement doses in a hypothyroid patient with familial dysalbuminemic hyperthyroxinemia (FDH)...
  42. ncbi Assessing the role of ortho-substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport protein
    K R Chauhan
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina, USA
    Toxicol Appl Pharmacol 162:10-21. 2000
    ..Previous structure-activity relationship (SAR) studies on second messengers and transthyretin (TTR; prealbumin) binding focused little attention on the ortho-substituted PCBs...
  43. ncbi Impact of varying levels of protein intake on protein status indicators after gastric bypass in patients with multiple complications requiring nutritional support
    Elizabeth Rinaldi Schinkel
    Department of Medical Nutrition Therapy, Poudre Valley Hospital, Fort Collins, CO 80524, and Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR, USA
    Obes Surg 16:24-30. 2006
    ..This study assesses the effect of varying protein-calorie intake in complicated patients after RYGBP on two markers of protein status: thyroxine-binding prealbumin (TBPA) and serum albumin.
  44. ncbi Evolution of the thyroid hormone-binding protein, transthyretin
    D M Power
    Centro de Ciências de MAR CCMAR, Universidade do Algarve, Campus de Gambelas, 8000 Faro, Portugal
    Gen Comp Endocrinol 119:241-55. 2000
    b>Transthyretin (TTR) belongs to a group of proteins, which includes thyroxine-binding globulin and albumin, that bind to and transport thyroid hormones in the blood...
  45. ncbi Transthyretin from discovery to now
    Jacob Robbins
    Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Chem Lab Med 40:1183-90. 2002
    As introduction to the First International Congress on Transthyretin in Health and Disease, this lecture traces the origin of the subjectfrom the discovery in the 1950s that a serum protein migrating ahead of albumin in an electrical ..
  46. ncbi Binding activities of thyroxine binding globulin versus thyroxine binding prealbumin in rat sera: differential modulation by thyroid hormone ligands, oleic acid and pharmacological drugs
    L Savu
    U 224, INSERM, Faculte de Medecine Xavier Bichat, Paris, France
    Biochem Biophys Res Commun 159:919-26. 1989
    ..and electrophoretic techniques to compare the binding properties of thyroxine binding globulin and thyroxine binding prealbumin in rat sera...
  47. ncbi Cloning of putative piscine (Sparus aurata) transthyretin: developmental expression and tissue distribution
    B Funkenstein
    Israel Oceanographic and Limnological Research, National Institute of Oceanography, Tel Shikmona, Haifa, Israel
    Mol Cell Endocrinol 157:67-73. 1999
    cDNA encoding putative transthyretin (prealbumin, TTR) was cloned from liver of the marine fish Sparus aurata. The cDNA contains an open reading frame of 453 nt, encoding for a TTR precursor of 151 amino acids...
  48. ncbi Observations with regard to the National Kidney Foundation K/DOQI clinical practice guidelines concerning serum transthyretin in chronic renal failure
    Joel D Kopple
    Division of Nephrology and Hypertension and the Research and Education Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Clin Chem Lab Med 40:1308-12. 2002
    ..Prealbumin, also known as serum transthyretin (TTR), was not recommended as a nutritional parameter of the same usefulness as the serum albumin...
  49. ncbi Electrically neutral microheterogeneity of human plasma transthyretin (prealbumin) detected by isoelectric focusing in urea gradients
    K Altland
    Institut fur Humangenetik, Justus Liebig Universitat, Giessen, Germany
    Electrophoresis 20:1349-64. 1999
    Mutants of the human plasma transthyretin (TTR, prealbumin) have attracted interest due to their rather frequent association with the autosomal dominant disease familial amyloidotic polyneuropathy (FAP)...
  50. ncbi [Fibril-forming proteins: the amyloidosis. New hopes for a disease that cardiologists must know]
    Eloisa Arbustini
    Laboratorio di Diagnostica Molecolare, Area Trapiantologica di Ricerca, IRCCS Policlinico San Matteo, Dipartimento di Biochimica, Universita degli Studi, Pavia
    Ital Heart J Suppl 3:590-7. 2002
    ..In transthyretin (TTR) amyloidosis, the non-senile forms are autosomal dominant diseases caused by defective proteins ..
  51. ncbi Cutaneous lymphatic amyloid deposits in "Hungarian-type" familial transthyretin amyloidosis: a case report
    Tibor Harkany
    Department of Molecular Neurobiology, University of Groningen, PO Box 14, Kerklaan 30, NL 9750 AA Haren, The Netherlands
    Br J Dermatol 146:674-9. 2002
    Multiple transthyretin (TTR) mutations have recently been identified and implicated in the development of familial systemic amyloidoses, but early diagnosis of these disorders is still largely unresolved...
  52. doi Chain reaction of amyloid fibril formation with induction of basement membrane in familial amyloidotic polyneuropathy
    Yohei Misumi
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 081, Japan
    J Pathol 219:481-90. 2009
    ..FAP) is characterized by extracellular deposition of amyloid fibrils caused by a point mutation in the transthyretin (TTR) gene...
  53. pmc Matrix metalloproteinases and their tissue inhibitors in cardiac amyloidosis: relationship to structural, functional myocardial changes and to light chain amyloid deposition
    Andreia Biolo
    Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Circ Heart Fail 1:249-57. 2008
    ..prognosis compared with non-light chain cardiac amyloidoses (ie, forms associated with wild-type or mutated transthyretin [TTR])...
  54. ncbi Risk of transmission of systemic transthyretin amyloidosis after domino liver transplantation
    Laura Llado
    Departments of Surgery, Liver Transplant Unit, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
    Liver Transpl 16:1386-92. 2010
    Recent reports of the transmission of systemic transthyretin (TTR) amyloidosis after domino liver transplantation (DLT) using grafts from patients with familial amyloid polyneuropathy (FAP) have raised concerns about the procedure...
  55. doi Risk of transmission of systemic transthyretin amyloidosis after domino liver transplantation
    Laura Llado
    Departments of Surgery, Liver Transplant Unit, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain
    Liver Transpl 16:1386-92. 2010
    Recent reports of the transmission of systemic transthyretin (TTR) amyloidosis after domino liver transplantation (DLT) using grafts from patients with familial amyloid polyneuropathy (FAP) have raised concerns about the procedure...
  56. ncbi Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses
    Yoshiki Sekijima
    Department of Neurology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Curr Pharm Des 14:3219-30. 2008
    b>Transthyretin (TTR) is a homotetrameric serum and cerebrospinal fluid protein that transports both thyroxine (T(4)) and the retinol-retinol binding protein complex (holoRBP)...
  57. ncbi Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: a possible model for senile systemic amyloidosis
    M H Teng
    Research Service, New York Department of Veterans Affairs Medical Center, New York, USA
    Lab Invest 81:385-96. 2001
    The human serum protein transthyretin (TTR) is highly fibrillogenic in vitro and is the fibril precursor in both autosomal dominant (familial amyloidotic polyneuropathy [FAP] and familial amyloidotic cardiomyopathy [FAC]) and sporadic (..
  58. ncbi Liver transplantation for hereditary transthyretin amyloidosis
    O B Suhr
    Department of Medicine, Umea University Hospital, Umea, Sweden
    Liver Transpl 6:263-76. 2000
    b>Transthyretin (TTR) amyloidosis is the most common form of hereditary amyloidosis...
  59. ncbi Familial ATTR amyloidosis: microalbuminuria as a predictor of symptomatic disease and clinical nephropathy
    Luísa Lobato
    Department of Nephrology and Centro de Estudos de Paramiloidose, Hospital Geral de Santo António and Institute for Molecular and Cell Biology, Porto, Portugal
    Nephrol Dial Transplant 18:532-8. 2003
    Portuguese type familial amyloid polyneuropathy (FAP) is a neuropathic amyloidosis caused by a mutant transthyretin (TTR). Varying degrees of renal involvement have been reported...
  60. ncbi Sequence, genetic analysis, and expression of Actinobacillus pleuropneumoniae transferrin receptor genes
    G C Gonzalez
    Department of Microbiology and Infectious Diseases, University of Calgary, AB, Canada
    Microbiology 141:2405-16. 1995
    The tbpA and tbpB genes encoding the transferrin receptor proteins Tbp1 and Tbp2 from a serotype 7 strain of Actinobacillus pleuropneumoniae were cloned, sequenced, and expressed in Escherichia coli...
  61. ncbi A dynamic model of the meningococcal transferrin receptor
    I C Boulton
    Centre for Applied Microbiology and Research, Salisbury, SP4 0JG, UK
    J Theor Biol 198:497-505. 1999
    ..It has been established that transferrin-binding proteins (designated TbpA and TbpB) form a discrete, specific complex which may be composed of a transmembrane species (composed of the TbpA ..
  62. pmc Transferrin-binding protein B isolated from Neisseria meningitidis discriminates between apo and diferric human transferrin
    I C Boulton
    Metalloprotein Research Group, Division of Biochemistry and Molecular Biology, United Medical and Dental School of Guy s and St Thomas s Hospitals, Guy s Hospital, London SE1 9RT
    Biochem J 334:269-73. 1998
    ..To characterize this process, functionally active meningococcal transferrin-binding protein A (TbpA) and TbpB have been purified from N. meningitidis using a novel purification procedure...
  63. ncbi Thyroid function in sojourners and acclimatised low landers at high altitude in man
    R C Sawhney
    Defence Institute of Physiology and Allied Sciences, Delhi Cantonment, India
    Horm Metab Res 23:81-4. 1991
    ..01) at HA, whereas plasma rT3, TBG and T4 binding capacities of TBG and TBPA did not show any appreciable change...
  64. pmc Neisseria meningitidis expressing transferrin binding proteins of Actinobacillus pleuropneumoniae can utilize porcine transferrin for growth
    D J Litt
    Institute of Infections and Immunity, Queen s Medical Centre, Nottingham, NG7 2UH, United Kingdom
    Infect Immun 68:550-7. 2000
    ..or porcine transferrin because of loss of both transferrin binding proteins (Tbp) A and B [strain B16B6(Str(r))/tbpA(-)B(-)] and (ii) an ability to bind porcine transferrin but not human transferrin [strain B16B6(Str(r))/tbpA(ap)B(..
  65. ncbi Low serum levels of prohepcidin, but not hepcidin-25, are related to anemia in familial amyloidosis TTR V30M
    Idalina Beirão
    Department of Nephrology, HGSA, Santo Antonio General Hospital, Porto, Portugal
    Blood Cells Mol Dis 41:175-8. 2008
    ..In general, the decreased observed/expected EPO levels in FAP-I correlated with the prohepcidin levels, therefore raising the possibility that a common defect in these two hormones may be somehow involved in the genesis of the disease...
  66. pmc Evidence for a common gene pool and frequent recombinational exchange of the tbpBA operon in Mannheimia haemolytica, Mannheimia glucosida and Bibersteinia trehalosi
    Inkyoung Lee
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, 120 University Place, University of Glasgow, Glasgow G12 8TA, UK
    Microbiology 157:123-35. 2011
    ..A total of 27 tbpB and 20 tbpA alleles were identified whilst the tbpBA operon was represented by 28 unique alleles that could be assigned to ..
  67. pmc TTR familial amyloid polyneuropathy: does a mitochondrial polymorphism entirely explain the parent-of-origin difference in penetrance?
    Bernard Bonaïti
    INRA GABI, Jouy en Josas, France
    Eur J Hum Genet 18:948-52. 2010
    The Val30Met transthyretin familial amyloid polyneuropathy (TTR-V30M-FAP) is the most frequent familial amyloidosis, with autosomal dominant transmission. This severe disease shows important differences in age of onset and penetrance...
  68. pmc Inhibition by lead of production and secretion of transthyretin in the choroid plexus: its relation to thyroxine transport at blood-CSF barrier
    W Zheng
    School of Public Health, Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Toxicol Appl Pharmacol 155:24-31. 1999
    Long-term, low-dose Pb exposure in rats is associated with a significant decrease in transthyretin (TTR) concentrations in the CSF...
  69. pmc Identification of TbpA residues required for transferrin-iron utilization by Neisseria gonorrhoeae
    Jennifer M Noto
    Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0678, USA
    Infect Immun 76:1960-9. 2008
    ..The gonococcal transferrin-iron uptake system is composed of two transferrin binding proteins, TbpA and TbpB...
  70. ncbi Detection and subtyping of Actinobacillus pleuropneumoniae strains by PCR-RFLP analysis of the tbpA and tbpB genes
    V A de la Puente Redondo
    Section of Microbiology and Immunology, Department of Animal Health, Faculty of Veterinary Medicine, , Spain
    Res Microbiol 151:669-81. 2000
    ..The A. pleuropneumoniae tbpA and tbpB genes were used as targets for amplification of DNA fragments, with a pair of specific primers for each ..
  71. ncbi Thyroxine binding in a TTR Met 119 kindred
    I L Alves
    Centro de Estudos de Paramiloidose, Hospital de Santo Antonio, Porto, Portugal
    J Clin Endocrinol Metab 77:484-8. 1993
    Recently, a transthyretin variant, TTR Met 119, in which methionine substitutes for threonine 119, a component of the protein's iodothyronine binding site, was identified in individuals with transient euthyroid hyperthyroxinemia...
  72. pmc Transthyretin, thyroxine, and retinol-binding protein in human cerebrospinal fluid: effect of lead exposure
    W Zheng
    Division of Environmental Health Sciences, School of Public Health, Columbia University, New York, New York 10032, USA
    Toxicol Sci 61:107-14. 2001
    b>Transthyretin (TTR), synthesized by the choroid plexus, is proposed to have a role in transport of thyroid hormones in the brain...
  73. ncbi A new transthyretin variant (Glu61Gly) associated with cardiomyopathy
    Michael Rosenzweig
    Amyloid Treatment and Research Program, Boston University School of Medicine, MA 02118, USA
    Amyloid 14:65-71. 2007
    We report the identification of a new transthyretin (TTR) gene mutation and variant protein, Glu61Gly, in a 55-year-old man with progressive cardiomyopathy, mild peripheral neuropathy and bilateral carpal tunnel syndrome...
  74. ncbi Secondary glaucoma in patients with familial amyloidotic polyneuropathy
    Akira Kimura
    Department of Ophthalmology, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Arch Ophthalmol 121:351-6. 2003
    To elucidate the clinical features and surgical outcomes of the treatment of secondary glaucoma associated with transthyretin (TTR)-related familial amyloidotic polyneuropathy (FAP).
  75. pmc Gonococcal genes encoding transferrin-binding proteins A and B are arranged in a bicistronic operon but are subject to differential expression
    C Ronpirin
    Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0678, USA
    Infect Immun 69:6336-47. 2001
    ..The receptor involved in transferrin iron acquisition is composed of two distinct transferrin-binding proteins, TbpA and TbpB...
  76. ncbi The evolutionary and integrative roles of transthyretin in thyroid hormone homeostasis
    G Schreiber
    Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, 3010 Victoria, Australia
    J Endocrinol 175:61-73. 2002
    In larger mammals, thyroid hormone-binding plasma proteins are albumin, transthyretin (TTR) and thyroxine (T4)-binding globulin. They differ characteristically in affinities and release rates for T4 and triiodothyronine (T3)...
  77. pmc Demonstration and characterization of a specific interaction between gonococcal transferrin binding protein A and TonB
    Christopher D Kenney
    Department of Pathology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond 23298 0678, USA
    J Bacteriol 184:6138-45. 2002
    ..Efficient transferrin-iron acquisition is dependent on the combined action of two proteins, designated TbpA and TbpB...
  78. pmc tert-Butylphenylacetylene is a potent mechanism-based inactivator of cytochrome P450 2B4: inhibition of cytochrome P450 catalysis by steric hindrance
    Haoming Zhang
    Department of Pharmacology, The University of Michigan, Ann Arbor, MI 48109 5632, USA
    Mol Pharmacol 76:1011-8. 2009
    We have demonstrated that 4-(tert-butyl)-phenylacetylene (tBPA) is a potent mechanism-based inactivator for cytochrome P450 2B4 (P450 2B4) in the reconstituted system...
  79. pmc Purified meningococcal transferrin-binding protein B interacts with a secondary, strain-specific, binding site in the N-terminal lobe of human transferrin
    I C Boulton
    Metalloprotein Research Group, Division of Biomolecular Sciences, King s College London, Guy s Campus, Guy s Hospital, London SE1 9RT, UK
    Biochem J 339:143-9. 1999
    Neisseria meningitidis, grown in iron-limited conditions, produces two transferrin-binding proteins (TbpA and TbpB) that independently and specifically bind human serum transferrin (hTF) but not bovine serum transferrin (bTF)...
  80. ncbi Differential binding of apo and holo human transferrin to meningococci and co-localisation of the transferrin-binding proteins (TbpA and TbpB)
    N B Powell
    Microbial Pathogenicity Research Group, Institute of Infections and Immunity, Queen s Medical Centre, Nottingham
    J Med Microbiol 47:257-64. 1998
    ..001). The ability of meningococcal mutants lacking either transferrin-binding protein A (TbpA) or TbpB to discriminate between apo-hTf and holo-hTf was also investigated...
  81. doi Structure-based investigation on the binding interaction of hydroxylated polybrominated diphenyl ethers with thyroxine transport proteins
    Jie Cao
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, P O Box 2871, Beijing 100085, China
    Toxicology 277:20-8. 2010
    ..Binding affinity of the 14 OH-PBDEs with transthyretin (TTR) and thyroxine-binding globulin (TBG) was measured by competitive fluorescence displacement assay...
  82. ncbi Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice model
    I Cardoso
    Molecular Neurobiology, IBMC, Porto University, Porto, Portugal
    FASEB J 20:234-9. 2006
    ..polyneuropathy is an autosomal dominant disorder mainly characterized by the extracellular deposition of transthyretin, with special involvement of the peripheral nerve...
  83. ncbi Determination of a cut-off value for the molar ratio of retinol-binding protein to transthyretin (RBP:TTR) in Bangladeshi patients with low hepatic vitamin A stores
    Francisco J Rosales
    Nutrition Department, The Pennsylvania State University, University Park, USA
    J Nutr 132:3687-92. 2002
    The purpose of this study was to determine a cut-off value of the molar ratio of retinol-binding protein to transthyretin (RBP:TTR) to indicate marginal vitamin A (VA) deficiency...
  84. ncbi Molecular cloning, tissue distribution, and developmental expression of lamprey transthyretins
    Richard G Manzon
    Department of Biology, University of Regina, 3737 Wascana Parkway, Regina, Sask, Canada S4S 0A2
    Gen Comp Endocrinol 151:55-65. 2007
    We isolated and cloned full-length cDNAs of transthyretin (TTR) from 2 genera of lamprey, Petromyzon marinus and Lampetra appendix. These sequences represent the first report of TTR sequences in vertebrates basal to teleost fishes...
  85. ncbi Homology modelling of transferrin-binding protein A from Neisseria meningitidis
    Jonathan S Oakhill
    Metalloprotein Research Group, Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, UK
    Protein Eng Des Sel 18:221-8. 2005
    ..meningitis, obtains transferrin-bound iron by expressing two outer membrane located transferrin-binding proteins, TbpA and TbpB. TbpA is thought to be an integral outer membrane pore that facilitates iron uptake...
  86. ncbi ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity
    Márcia Almeida Liz
    Molecular Neurobiology Group, Instituto de Biologia Molecular e Celular IBMC, Porto, Portugal
    J Lipid Res 48:2385-95. 2007
    A fraction of plasma transthyretin (TTR) circulates in HDL through binding to apolipoprotein A-I (apoA-I). Moreover, TTR is able to cleave the C terminus of lipid-free apoA-I...
  87. pmc Meningococcal transferrin-binding proteins A and B show cooperation in their binding kinetics for human transferrin
    Russell H Stokes
    Metalloprotein Research Group, Randall Division of Cell and Molecular Biophysics, GKT School of Biomedical Sciences, King s College London, Guy s Campus, New Hunt s House, London SE1 1UL, United Kingdom
    Infect Immun 73:944-52. 2005
    ..septicemia, obtains transferrin-bound iron by expressing two outer membrane-located transferrin-binding proteins, TbpA and TbpB. A novel system was developed to investigate the interaction between Tbps and human transferrin...
  88. ncbi Synthesis of transthyretin by the ependymal cells of the subcommissural organ
    H A Montecinos
    Facultad de Medicina, Instituto de Histologia y Patologia, Universidad Austral de Chile, Casilla de Correo P O Box 567, Valdivia, Chile
    Cell Tissue Res 320:487-99. 2005
    b>Transthyretin (TTR) is a protein involved in the transport of thyroid hormones in blood and cerebrospinal fluid (CSF). The only known source of brain-produced TTR is the choroid plexus...
  89. ncbi Use of the retinol-binding protein: transthyretin ratio for assessment of vitamin A status during the acute-phase response
    S M Filteau
    Centre for International Child Health, Institute of Child Health, London, UK
    Br J Nutr 83:513-20. 2000
    The ratio plasma retinol-binding protein (RBP):transthyretin (TTR) has been proposed as a means to improve the assessment of vitamin A status of individuals with concurrent infection or inflammation...
  90. ncbi Regulation of transthyretin by thyroid hormones in fish
    I Morgado
    CCMAR, Universidade do Algarve, Campus de Gambelas, 8005 139 Faro, Portugal
    Gen Comp Endocrinol 152:189-97. 2007
    b>Transthyretin (TTR) is a thyroid hormone-binding protein (THBP) which in its tetrameric form transports thyroid hormones (THs), thyroxine (T(4)) and triiodothyronine (T(3)) in the blood of vertebrates...
  91. ncbi Taxanes for the adjuvant treatment of early breast cancer: systematic review and economic evaluation
    S Ward
    School of Health and Related Research ScHARR, University of Sheffield, UK
    Health Technol Assess 11:1-144. 2007
    ..To estimate the clinical effectiveness and cost-effectiveness of docetaxel and paclitaxel compared with non-taxane, anthracycline-containing chemotherapy regimens, for the adjuvant treatment of women with early-stage breast cancer...
  92. ncbi Insight into the structure and function of the transferrin receptor from Neisseria meningitidis using microcalorimetric techniques
    Tino Krell
    Aventis Pasteur, 1541 Avenue Marcel Merieux, 69280 Marcy l Etoile, France
    J Biol Chem 278:14712-22. 2003
    The transferrin receptor of Neisseria meningitidis is composed of the transmembrane protein TbpA and the outer membrane protein TbpB. Both receptor proteins have the capacity to independently bind their ligand human transferrin (htf)...
  93. pmc Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative
    Maria Rosário Almeida
    Molecular Neurobiology Unit, Instituto de Biologia Molecular e Celular e Departamento de Biologia Molecular, ICBAS Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4150 180 Porto, Portugal
    Biochem J 381:351-6. 2004
    In familial amyloidotic polyneuropathy, TTR (transthyretin) variants are deposited as amyloid fibrils...
  94. doi Galactose binds to focal segmental glomerulosclerosis permeability factor and inhibits its activity
    Virginia J Savin
    Medical College of Wisconsin, Kidney Disease Center, Milwaukee, WI, USA
    Transl Res 151:288-92. 2008
    Focal segmental glomerulosclerosis (FSGS) is associated with circulating permeability activity (Palb) and recurs after transplantation in about 30% of patients...
  95. pmc Human opsonins induced during meningococcal disease recognize transferrin binding protein complexes
    A K Lehmann
    Institute of Medicine, University of Bergen, N 5021 Bergen, Norway
    Infect Immun 67:6526-32. 1999
    Patient serum opsonins against transferrin binding protein A+B (TbpA+B) complexes from two Neisseria meningitidis strains (K454 and B16B6, with 85- and 68-kDa TbpB, respectively) were quantified by a functional phagocytosis and oxidative ..
  96. ncbi Transthyretin regulates thyroid hormone levels in the choroid plexus, but not in the brain parenchyma: study in a transthyretin-null mouse model
    J A Palha
    Unidade de Amiloide, Instituto de Biologia Molecular e Celular, Porto, Portugal
    Endocrinology 141:3267-72. 2000
    b>Transthyretin (TTR) is the major T4-binding protein in rodents. Using a TTR-null mouse model we asked the following questions...
  97. doi Structural modifications of serum transthyretin in rats during protein-energy malnutrition
    Andrea Henze
    University of Potsdam, Institute of Nutritional Science, Department of Physiology and Pathophysiology, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Rapid Commun Mass Spectrom 22:3270-4. 2008
    b>Transthyretin (TTR) is a sensitive marker of protein-energy malnutrition and changes in serum and expression levels during protein and energy deficiency are well described...
  98. doi Tear physiology of aqueous deficiency and evaporative dry eye
    Santosh Khanal
    School of Natural Sciences, University of Western Sydney, New South Wales, Australia
    Optom Vis Sci 86:1235-40. 2009
    ..To determine the differences in tear physiology between aqueous deficiency dry eye (ADDE) and evaporative dry eye (EDE), and evaluate their utility in diagnosis...
  99. ncbi A genetically engineered purpurin/retinol-binding protein hybrid that binds to transthyretin
    H Melhus
    Department of Cell Research, Uppsala University, Sweden
    Biochem Biophys Res Commun 184:938-44. 1992
    ..In contrast to RBP, expressed purpurin did not bind to transthyretin (TTR)...
  100. doi Characterization of a recombinant transferrin-binding protein A (TbpA) fragment from Haemophilus parasuis serovar 5
    Sonia Martinez
    Departamento de Sanidad Animal, Facultad de Veterinaria, Unidad de Microbiologia e Inmunologia, Universidad de Leon, Leon, Spain
    FEMS Microbiol Lett 307:142-50. 2010
    ..This receptor is composed of transferrin-binding protein A (TbpA) and TbpB. As it has been reported for other gram-negative organisms, H...
  101. pmc The transferrin binding protein B of Moraxella catarrhalis elicits bactericidal antibodies and is a potential vaccine antigen
    L E Myers
    Pasteur Merieux Connaught Canada Research, North York, Ontario, Canada M2R 3T4
    Infect Immun 66:4183-92. 1998
    The transferrin binding protein genes (tbpA and tbpB) from two strains of Moraxella catarrhalis have been cloned and sequenced. The genomic organization of the M...

Research Grants93

  1. PROBING THE BIOCHEMICAL MECHANISM OF AMYLOID DISEASES
    Jeffery Kelly; Fiscal Year: 1999
    ..In the familial disease, a mutated form transthyretin (prealbumin) (TTR) is deposited as fibrils in peripheral nerves or in specific organs while in the senile form ..
  2. PROBING THE BIOCHEMICAL MECHANISM OF AMYLOID DISEASES
    Jeffery Kelly; Fiscal Year: 2000
    ..In the familial disease, a mutated form transthyretin (prealbumin) (TTR) is deposited as fibrils in peripheral nerves or in specific organs while in the senile form ..
  3. PROBING THE BIOCHEMICAL MECHANISM OF AMYLOID DISEASES
    Jeffery Kelly; Fiscal Year: 2001
    ..In the familial disease, a mutated form transthyretin (prealbumin) (TTR) is deposited as fibrils in peripheral nerves or in specific organs while in the senile form ..
  4. BIOSYNTHETIC ACTIVITY OF THE CHOROID PLEXUS
    Joseph Herbert; Fiscal Year: 1990
    ..We (and others) have demonstrated the specific and abundant synthesis of transthyretin (TTR, prealbumin), a transport protein for thyroxine and retinol, within the CP epithelium...
  5. GENE EXPRESSION IN FAMILIAL AND SENILE CARDIAC AMYLOID
    Joel Buxbaum; Fiscal Year: 1990
    ..Systemic (cardiac) Amyloidosis have been shown to be caused by the deposition of thyroxine-binding prealbumin (transthyretin)-related molecules in various tissues, notably peripheral and autonomic nerves, heart, gastrointestinal tract, ..
  6. GENE EXPRESSION IN FAMILIAL AND SENILE CARDIAC AMYLOID
    Joel Buxbaum; Fiscal Year: 1993
    ..Systemic (cardiac) Amyloidosis have been shown to be caused by the deposition of thyroxine-binding prealbumin (transthyretin)-related molecules in various tissues, notably peripheral and autonomic nerves, heart, gastrointestinal tract, ..
  7. THYROID HORMONE ANALOGS
    Manfred Wolff; Fiscal Year: 1980
    ..vitro tests include measurement of relative binding affinities to the plasma protein, thyroxine-binding prealbumin (TBPA), and to hormone receptor preparations from rat liver cell nuclei...
  8. Molecular mechanism of senile cardiac amyloidosis
    Lawreen H Connors; Fiscal Year: 2013
    ..In SSA, wild-type transthyretin (TTR), normally a serum protein, forms amyloid deposits which disrupt normal cardiac cell functioning...
  9. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..We have documented that serum or plasma from FSGS patients increases glomerular albumin permeability (Palb) and that the specific activity of certain protein fractions of FSGS plasma is more than 10,000-fold greater than ..
  10. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia Savin; Fiscal Year: 2009
    ..We have documented that serum or plasma from FSGS patients increases glomerular albumin permeability (Palb) and that the specific activity of certain protein fractions of FSGS plasma is more than 10,000-fold greater than ..
  11. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2009
    ..We have documented that serum or plasma from FSGS patients increases glomerular albumin permeability (Palb) and that the specific activity of certain protein fractions of FSGS plasma is more than 10,000-fold greater than ..
  12. INHIBITION OF AMYLOID FORMATION BY TRANSTHYRETIN & APOE
    Dmitry Goldgaber; Fiscal Year: 1999
    ..Recently, we found that two Ab binding proteins, transthyretin (TTR) and apolipoprotein E (apoE), inhibit Ab amyloid formation in vitro...
  13. Mechanistic studies of transthyretin misfolding and amyloid formation through a c
    Kwang Hun Lim; Fiscal Year: 2013
    ..This research program is aimed at investigating amyloid formation mechanisms of a natively folded protein, transthyretin (TTR), using both solution and solid-state NMR...
  14. SOLID STATE NMR STUDIES OF PEPTIDES AND PROTEINS
    Robert Griffin; Fiscal Year: 2009
    ..1) With ssNMR measurements of intermolecular distances on both the WT TTR and L111M mutant peptides from transthyretin we plan to refine the structures of the amyloid protofilaments formed by these two peptides...
  15. SOLID STATE NMR STUDIES OF PEPTIDES AND PROTEINS
    ROBERT GUY GRIFFIN; Fiscal Year: 2010
    ..1) With ssNMR measurements of intermolecular distances on both the WT TTR and L111M mutant peptides from transthyretin we plan to refine the structures of the amyloid protofilaments formed by these two peptides...
  16. SOLID STATE NMR STUDIES OF PEPTIDES AND PROTEINS
    Robert Griffin; Fiscal Year: 2009
    ..1) With ssNMR measurements of intermolecular distances on both the WT TTR and L111M mutant peptides from transthyretin we plan to refine the structures of the amyloid protofilaments formed by these two peptides...
  17. Multidisciplinary Clinical and Translational Science (MCTS) Program (UL1)
    Philip Greenland; Fiscal Year: 2009
    ..2.2) Regulatory Support Program 813 (2.3) Biomedical Informatics Center :..... 830 (2.4) Center for Clinical Research Education 848 PHS 398/2590 (Rev. 09/64; Reissued4/2006) Page 7 Continuation Format Page ..
  18. Novel Insights into the Pathogenesis of Light Chain Cardiac Amyloidosis
    Flora Sam; Fiscal Year: 2011
    ..e. amyloidosis associated with wild-type transthyretin (TTR): the senile systemic amyloidosis (SSA) or a mutant transthyretin (ATTR);the prognosis for patients with ..
  19. Novel Insights into the Pathogenesis of Light Chain Cardiac Amyloidosis
    Flora Sam; Fiscal Year: 2010
    ..e. amyloidosis associated with wild-type transthyretin (TTR): the senile systemic amyloidosis (SSA) or a mutant transthyretin (ATTR);the prognosis for patients with ..
  20. Immunoglobulin Structure, Stability and Aging
    Yair Argon; Fiscal Year: 2009
    ....
  21. Immunoglobulin Structure, Stability and Aging
    Yair Argon; Fiscal Year: 2007
    ....
  22. Immunoglobulin Structure, Stability and Aging
    Yair Argon; Fiscal Year: 2006
    ....
  23. Immunoglobulin Structure, Stability and Aging
    Yair Argon; Fiscal Year: 2010
    ....
  24. Transthyretin's Regulatory Role in Beta-Amyloid Aggregation and Toxicity
    REGINA M contact MURPHY; Fiscal Year: 2010
    b>Transthyretin's Regulatory Role in Beta-Amyloid Aggregation and Toxicity Alzheimer's disease (AD) has been linked to deposition of beta-amyloid (A) as amyloid plaques in the brain...
  25. Transthyretin's Regulatory Role in Beta-Amyloid Aggregation and Toxicity
    REGINA MURPHY; Fiscal Year: 2009
    b>Transthyretin's Regulatory Role in Beta-Amyloid Aggregation and Toxicity Alzheimer's disease (AD) has been linked to deposition of beta-amyloid (A) as amyloid plaques in the brain...
  26. Cardiac Amyloidosis in Aging African American
    Joel N Buxbaum; Fiscal Year: 2011
    ..form of late-onset amyloidosis due to a substitution of ILE for VAL at position 122 in the serum protein transthyretin (TTR) contributes to this racial disparity...
  27. PATHOGENESIS OF HEREDITARY TRANSTHYRETIN AMYLOIDOSIS
    Merrill Benson; Fiscal Year: 2002
    ..abstract): The overall objective of this proposal is to define the pathophysiology of the autosomal dominant transthyretin amyloidoses...
  28. PATHOGENESIS OF HEREDITARY TRANSTHYRETIN AMYLOIDOSIS
    Merrill Benson; Fiscal Year: 2001
    ..abstract): The overall objective of this proposal is to define the pathophysiology of the autosomal dominant transthyretin amyloidoses...
  29. PATHOGENESIS OF HEREDITARY TRANSTHYRETIN AMYLOIDOSIS
    Merrill Benson; Fiscal Year: 2003
    ..abstract): The overall objective of this proposal is to define the pathophysiology of the autosomal dominant transthyretin amyloidoses...
  30. PATHOGENESIS OF HEREDITARY TRANSTHYRETIN AMYLOIDOSIS
    Merrill Benson; Fiscal Year: 2000
    ..abstract): The overall objective of this proposal is to define the pathophysiology of the autosomal dominant transthyretin amyloidoses...
  31. PATHOGENESIS OF HEREDITARY TRANSTHYRETIN AMYLOIDOSIS
    Merrill Benson; Fiscal Year: 1999
    The overall objective of this proposal is to define the pathophysiology of the autosomal dominant transthyretin amyloidoses...
  32. PROTEIN BINDING INTERACTIONS OF THYROACTIVE COMPOUNDS
    Vivian Cody; Fiscal Year: 1993
    ..mechanisms regulating thyroid hormone action, in particular binding to the human serum transport protein transthyretin (TTR)...
  33. Cardiac Amyloidosis in Aging African Americans
    Joel Buxbaum; Fiscal Year: 2001
    ..form of late-onset amyloidosis due to a substitution of ILE for VAL at position 122 in the serum protein transthyretin (TTR)...
  34. Cardiac Amyloidosis in Aging African Americans
    Joel Buxbaum; Fiscal Year: 2003
    ..form of late-onset amyloidosis due to a substitution of ILE for VAL at position 122 in the serum protein transthyretin (TTR)...
  35. Cardiac Amyloidosis in Aging African Americans
    Joel Buxbaum; Fiscal Year: 2005
    ..form of late-onset amyloidosis due to a substitution of ILE for VAL at position 122 in the serum protein transthyretin (TTR)...
  36. Cardiac Amyloidosis in Aging African Americans
    Joel Buxbaum; Fiscal Year: 2002
    ..form of late-onset amyloidosis due to a substitution of ILE for VAL at position 122 in the serum protein transthyretin (TTR)...
  37. Cardiac Amyloidosis in Aging African Americans
    Joel Buxbaum; Fiscal Year: 2004
    ..form of late-onset amyloidosis due to a substitution of ILE for VAL at position 122 in the serum protein transthyretin (TTR)...
  38. Cardiac Amyloidosis in Aging African Americans
    Joel Buxbaum; Fiscal Year: 2004
    ..form of late-onset amyloidosis due to a substitution of ILE for VAL at position 122 in the serum protein transthyretin (TTR)...
  39. Indiana Clinical and Translational Science Institute (UL1)
    Anantha Shekhar; Fiscal Year: 2013
    ..V. Leverage the Resources of the Greater Indiana Community by connecting to a broad array of resources from multiple partner institutions throughout the state to realize the full potential of the Indiana CTSI...
  40. Cardiac Amyloidosis in Aging African American
    Joel Buxbaum; Fiscal Year: 2009
    ..form of late-onset amyloidosis due to a substitution of ILE for VAL at position 122 in the serum protein transthyretin (TTR) contributes to this racial disparity...
  41. Cardiac Amyloidosis in Aging African American
    Joel N Buxbaum; Fiscal Year: 2010
    ..form of late-onset amyloidosis due to a substitution of ILE for VAL at position 122 in the serum protein transthyretin (TTR) contributes to this racial disparity...
  42. RETINOL TRANSPORT PROTEINS IN RETINAL PIGMENT EPITHELIUM
    Joseph Herbert; Fiscal Year: 1992
    ..Plasma retinol is transported, from the liver to the eye in complex with two plasma proteins: serum transthyretin (TTR) and serum retinol-binding protein (SRBP)...
  43. METABOLISM AND NUTRITION
    DE WITT GOODMAN; Fiscal Year: 1990
    ..pathways and processes involved and their regulation; (5) the tissue sites of catabolism of RBP and transthyretin (TTR); (6) cell surface receptors for RBP; (7) the functional domains of RBP by means of monoclonal antibodies ..
  44. METABOLISM AND NUTRITION
    DE WITT GOODMAN; Fiscal Year: 1991
    ..pathways and processes involved and their regulation; (5) the tissue sites of catabolism of RBP and transthyretin (TTR); (6) cell surface receptors for RBP; (7) the functional domains of RBP by means of monoclonal antibodies ..
  45. METABOLISM AND NUTRITION
    WILLIAM BLANER; Fiscal Year: 1992
    ..pathways and processes involved and their regulation; (5) the tissue sites of catabolism of RBP and transthyretin (TTR); (6) cell surface receptors for RBP; (7) the functional domains of RBP by means of monoclonal antibodies ..
  46. CNS DEVELOPMENT UNDER HYPERGRAVITY : MODULATION BY TH?
    ELIZABETH SAJDEL SULKOWSKA; Fiscal Year: 2002
    ..These studies will aid in developing an understanding of how altered gravity affects CNS development, what role the thyroid hormone plays in that response, and whether this response can be modulated by hormonal therapy. ..
  47. CNS DEVELOPMENT UNDER HYPERGRAVITY : MODULATION BY TH?
    ELIZABETH SAJDEL SULKOWSKA; Fiscal Year: 2003
    ..These studies will aid in developing an understanding of how altered gravity affects CNS development, what role the thyroid hormone plays in that response, and whether this response can be modulated by hormonal therapy. ..
  48. CNS DEVELOPMENT UNDER HYPERGRAVITY : MODULATION BY TH?
    ELIZABETH SAJDEL SULKOWSKA; Fiscal Year: 2004
    ..These studies will aid in developing an understanding of how altered gravity affects CNS development, what role the thyroid hormone plays in that response, and whether this response can be modulated by hormonal therapy. ..
  49. CHOROID PLEXUS AS A TARGET IN LEAD INDUCED NEUROTOXICITY
    Wei Zheng; Fiscal Year: 1999
    ..Recently, we demonstrated that deposition of Pb in CP is associated with a significant decrease in CSF transthyretin concentration...
  50. CHOROID PLEXUS AS A TARGET IN LEAD INDUCED NEUROTOXICITY
    Wei Zheng; Fiscal Year: 2000
    ..Recently, we demonstrated that deposition of Pb in CP is associated with a significant decrease in CSF transthyretin concentration...
  51. MOLECULAR BASIS OF DIFFERENT TRANSTHYRETIN GENE CONTROL
    Terry van Dyke; Fiscal Year: 1991
    DESCRIPTION (Adapted from the applicant's abstract): Transthyretin (TTR) is a thyroid hormone transport protein that is secreted by hepatocytes into the serum and by the choroid plexus epithelium into the cerebral spinal fluid...
  52. Effect of diflunisal (IND68092) on familial amyloidosis
    JOHN BERK; Fiscal Year: 2009
    Familial amyloidotic polyneuropathy (FAP) is a lethal autosomal dominant disease mediated by misfolding of transthyretin, a transport protein produced by the liver...
  53. Effect of diflunisal (IND68092) on familial amyloidosis
    JOHN BERK; Fiscal Year: 2005
    Familial amyloidotic polyneuropathy (FAP) is a lethal autosomal dominant disease mediated by misfolding of transthyretin, a transport protein produced by the liver...
  54. Effect of diflunisal (IND68092) on familial amyloidosis
    JOHN BERK; Fiscal Year: 2007
    Familial amyloidotic polyneuropathy (FAP) is a lethal autosomal dominant disease mediated by misfolding of transthyretin, a transport protein produced by the liver...
  55. Effect of diflunisal (IND68092) on familial amyloidosis
    JOHN BERK; Fiscal Year: 2006
    Familial amyloidotic polyneuropathy (FAP) is a lethal autosomal dominant disease mediated by misfolding of transthyretin, a transport protein produced by the liver...
  56. REGULATION OF THYROID FUNCTION T4 AND T3 KINETICS
    Lewis Braverman; Fiscal Year: 1990
    ..A synthetic flavonoid, EMD 21388 (F), which inhibits the serum protein binding (TBPA) of the TH and 5'- deiodinase activity (5'-D) in vitro will be utilized to study, in the rat, the in vivo effects ..
  57. TRANSTHYRETIN IN FAMILIAL AMYLOIDOTIC POLYNEUROPHATHY
    Martha Skinner; Fiscal Year: 1991
    ..FAP) is an autosomal dominantly inherited condition associated with a mutant form of the protein transthyretin (TTR, also called pre-albumin)...
  58. Abcb11 and Hepatic Transport
    Anne Henkel; Fiscal Year: 2009
    ..We will characterize the role of bile salts in regulating gene and protein expression in the TTR-Abcb11 model as a means to establish the mechanism by which Abcbl 1 predisposes to cholelithiasis and hepatic steatosis. ..
  59. Abcb11 and Hepatic Transport
    Anne Henkel; Fiscal Year: 2007
    ..We will characterize the role of bile salts in regulating gene and protein expression in the TTR-Abcb11 model as a means to establish the mechanism by which Abcbl 1 predisposes to cholelithiasis and hepatic steatosis. ..
  60. PHYSIOLOGY OF ATRIAL NATRIURETIC FACTOR IN TRANSGENIC MI
    Loren Field; Fiscal Year: 1990
    ..These experiments will enable us to understand the physiological role that ANF exerts in chronic cardiovascular regulation...
  61. Improving Depression Treatment Outcomes with an Insulin-Sensitizing Agent
    Patrick J Lustman; Fiscal Year: 2010
    ..The findings would represent a significant advance in depression treatment. ..
  62. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir K Dutta; Fiscal Year: 2010
    ..Fourth, high affinity binding of hydroxylated PCBs to Transthyretin (TTR) results in selective delivery of these hormones over the blood-brain barrier and over the placenta to ..
  63. Improving Depression Treatment Outcomes with an Insulin-Sensitizing Agent
    Patrick Lustman; Fiscal Year: 2007
    ..The findings would represent a significant advance in depression treatment. ..
  64. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir Dutta; Fiscal Year: 2007
    ..Fourth, high affinity binding of hydroxylated PCBs to Transthyretin (TTR) results in selective delivery of these hormones over the blood-brain barrier and over the placenta to ..
  65. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir Dutta; Fiscal Year: 2009
    ..Fourth, high affinity binding of hydroxylated PCBs to Transthyretin (TTR) results in selective delivery of these hormones over the blood-brain barrier and over the placenta to ..
  66. Improving Depression Treatment Outcomes with an Insulin-Sensitizing Agent
    Patrick Lustman; Fiscal Year: 2009
    ..The findings would represent a significant advance in depression treatment. ..
  67. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir K Dutta; Fiscal Year: 2010
    ..Fourth, high affinity binding of hydroxylated PCBs to Transthyretin (TTR) results in selective delivery of these hormones over the blood-brain barrier and over the placenta to ..
  68. ETIOLOGIC FACTOR IN FOCAL GLOMERULOSCLEROSIS
    Virginia Savin; Fiscal Year: 2000
    ..therapy, and our observation that plasma from FSGS patients increases glomerular albumin permeability (Palb) following in vitro incubation of isolated glomeruli to serum or plasma of certain FSGS patients...
  69. ETIOLOGIC FACTOR IN FOCAL GLOMERULOSCLEROSIS
    Virginia Savin; Fiscal Year: 1999
    ..therapy, and our observation that plasma from FSGS patients increases glomerular albumin permeability (Palb) following in vitro incubation of isolated glomeruli to serum or plasma of certain FSGS patients...
  70. Retargeting HSV-1 Vectors to Motor Neurons
    Joseph Glorioso; Fiscal Year: 2002
    ..The soluble HveC adapter will be expected to block gD binding to cellular HveC while directly or indirectly re-targeting the virus to TTx receptors. ..
  71. Patient-Level Determinants of Oral Anticoagulation Control in the VHA
    Adam J Rose; Fiscal Year: 2013
    ..Finally, we will develop and pilot a tool to communicate our recommendations for quality improvement to each site. This tool will eventually serve as the basis for a project to improve anticoagulation care throughout the VHA. ..
  72. Retargeting HSV-1 Vectors to Motor Neurons
    Joseph Glorioso; Fiscal Year: 2004
    ..The soluble HveC adapter will be expected to block gD binding to cellular HveC while directly or indirectly re-targeting the virus to TTx receptors. ..
  73. Retargeting HSV-1 Vectors to Motor Neurons
    Joseph Glorioso; Fiscal Year: 2003
    ..The soluble HveC adapter will be expected to block gD binding to cellular HveC while directly or indirectly re-targeting the virus to TTx receptors. ..
  74. Testicular Torsion: Mechanisms and Treatment
    Terry Turner; Fiscal Year: 2003
    ..It is likely that these investigations will be relevant to other forms of oxidative stress inducing testicular dysfunction. ..