transferrin receptor

Summary

Gene Symbol: transferrin receptor
Description: transferrin receptor
Alias: CD71, IMD46, TFR, TFR1, TRFR, p90, transferrin receptor protein 1
Species: human
Products:     transferrin receptor

Top Publications

  1. Cheng Y, Zak O, Aisen P, Harrison S, Walz T. Structure of the human transferrin receptor-transferrin complex. Cell. 2004;116:565-76 pubmed
    ..the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR)...
  2. Feder J, Penny D, Irrinki A, Lee V, Lebron J, Watson N, et al. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci U S A. 1998;95:1472-7 pubmed
    ..or mutant HFE proteins that both the wild-type and H63D HFE proteins form stable complexes with the transferrin receptor (TfR). The C282Y mutation nearly completely prevents the association of the mutant HFE protein with the TfR...
  3. West A, Giannetti A, Herr A, Bennett M, Nangiana J, Pierce J, et al. Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites. J Mol Biol. 2001;313:385-97 pubmed
    The transferrin receptor (TfR) binds two proteins critical for iron metabolism: transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis...
  4. Nagabhushana A, Chalasani M, Jain N, Radha V, Rangaraj N, Balasubramanian D, et al. Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant. BMC Cell Biol. 2010;11:4 pubmed publisher
    ..We show that the knockdown of optineurin impairs trafficking of transferrin receptor to the juxtanuclear region...
  5. Alvarez E, Girones N, Davis R. Intermolecular disulfide bonds are not required for the expression of the dimeric state and functional activity of the transferrin receptor. EMBO J. 1989;8:2231-40 pubmed
    The human transferrin receptor is expressed as a disulfide-linked dimer at the cell surface. The sites of intermolecular disulfide bonds are Cys-89 and Cys-98...
  6. Buchegger F, Trowbridge I, Liu L, White S, Collawn J. Functional analysis of human/chicken transferrin receptor chimeras indicates that the carboxy-terminal region is important for ligand binding. Eur J Biochem. 1996;235:9-17 pubmed
    ..Different regions of the 671-residue external domain of the human transferrin receptor were replaced by the corresponding sequences from the chicken transferrin receptor...
  7. Fuchs H, Lücken U, Tauber R, Engel A, Gessner R. Structural model of phospholipid-reconstituted human transferrin receptor derived by electron microscopy. Structure. 1998;6:1235-43 pubmed
    The transferrin receptor (TfR) regulates the cellular uptake of serum iron...
  8. Dubljevic V, Sali A, Goding J. A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin. Biochem J. 1999;341 ( Pt 1):11-4 pubmed
    The transferrin receptor contains a highly conserved Arg-Gly-Asp (RGD) sequence in the C-terminal region where transferrin is thought to bind. RGD sequences are commonly involved in cell adhesion...
  9. Lawrence C, Ray S, Babyonyshev M, Galluser R, Borhani D, Harrison S. Crystal structure of the ectodomain of human transferrin receptor. Science. 1999;286:779-82 pubmed
    The transferrin receptor (TfR) undergoes multiple rounds of clathrin-mediated endocytosis and reemergence at the cell surface, importing iron-loaded transferrin (Tf) and recycling apotransferrin after discharge of iron in the endosome...

More Information

Publications111 found, 100 shown here

  1. Bennett M, Lebron J, Bjorkman P. Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor. Nature. 2000;403:46-53 pubmed
    ..HFE binds to the transferrin receptor (TfR), a receptor by which cells acquire iron-loaded transferrin. The 2...
  2. Raiborg C, Bache K, Gillooly D, Madshus I, Stang E, Stenmark H. Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nat Cell Biol. 2002;4:394-8 pubmed
    ..We conclude that Hrs sorts ubiquitinated membrane proteins into clathrin-coated microdomains of early endosomes, thereby preventing their recycling to the cell surface. ..
  3. Abraham J, Corbett K, Farzan M, Choe H, Harrison S. Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nat Struct Mol Biol. 2010;17:438-44 pubmed publisher
    ..The GP1 subunit of the surface glycoprotein mediates cell attachment through transferrin receptor 1 (TfR1). We report the structure of Machupo virus (MACV) GP1 bound with human TfR1...
  4. Enns C, Sussman H. Physical characterization of the transferrin receptor in human placentae. J Biol Chem. 1981;256:9820-3 pubmed
    The physical properties and binding characteristics of the solubilized transferrin receptor isolated from the placental brush-border membrane of a human trophoblast cell were investigated...
  5. Collawn J, Lai A, Domingo D, Fitch M, Hatton S, Trowbridge I. YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis. J Biol Chem. 1993;268:21686-92 pubmed
    ..We also report the complete primary structure of the Chinese hamster TR deduced from its cDNA sequence and show that the Tyr20 as well as the complete YTRF motif is conserved...
  6. Lebron J, Bennett M, Vaughn D, Chirino A, Snow P, Mintier G, et al. Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell. 1998;93:111-23 pubmed
    ..HFE binds to transferrin receptor (TfR) and reduces its affinity for iron-loaded transferrin, implicating HFE in iron metabolism. The 2...
  7. Dai J, Li J, Bos E, Porcionatto M, Premont R, Bourgoin S, et al. ACAP1 promotes endocytic recycling by recognizing recycling sorting signals. Dev Cell. 2004;7:771-6 pubmed
    ..We now show that ACAP1 binds specifically and directly to recycling cargo proteins. Reducing this interaction for TfR inhibits its recycling...
  8. Radoshitzky S, Abraham J, Spiropoulou C, Kuhn J, Nguyen D, Li W, et al. Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses. Nature. 2007;446:92-6 pubmed
    ..Here we show a specific, high-affinity association between transferrin receptor 1 (TfR1) and the entry glycoprotein (GP) of Machupo virus...
  9. Flanagan M, Oldenburg J, Reignier T, Holt N, Hamilton G, Martin V, et al. New world clade B arenaviruses can use transferrin receptor 1 (TfR1)-dependent and -independent entry pathways, and glycoproteins from human pathogenic strains are associated with the use of TfR1. J Virol. 2008;82:938-48 pubmed publisher
    ..been identified that are used by different pathogenic viruses, alpha-dystroglycan by Lassa fever virus and transferrin receptor 1 (TfR1) by certain New World clade B viruses...
  10. Herbison C, Thorstensen K, Chua A, Graham R, Leedman P, Olynyk J, et al. The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells. Am J Physiol Cell Physiol. 2009;297:C1567-75 pubmed publisher
    b>Transferrin receptor (TFR) 1 and 2 are expressed in the liver; TFR1 levels are regulated by cellular iron levels while TFR2 levels are regulated by transferrin saturation...
  11. Ying H, Shen X, Park B, Yue B. Posttranslational modifications, localization, and protein interactions of optineurin, the product of a glaucoma gene. PLoS ONE. 2010;5:e9168 pubmed publisher
    ..Optineurin also interacted with molecules including Rab8, myosin VI, and transferrin receptor to assemble into supermolecular complexes...
  12. Aisen P. Transferrin receptor 1. Int J Biochem Cell Biol. 2004;36:2137-43 pubmed
    ..immature red blood cells came the demonstration that a cell surface receptor, now known as transferrin receptor 1, is required for iron delivery from transferrin to cells...
  13. Magro G, Cataldo I, Amico P, Torrisi A, Vecchio G, Parenti R, et al. Aberrant expression of TfR1/CD71 in thyroid carcinomas identifies a novel potential diagnostic marker and therapeutic target. Thyroid. 2011;21:267-77 pubmed publisher
    Type I receptor for transferrin (TfR1/CD71) is overexpressed in several malignant tumors, but no studies are available on thyroid carcinomas...
  14. Akbari B, Farajnia S, Ahdi Khosroshahi S, Safari F, Yousefi M, Dariushnejad H, et al. Immunotoxins in cancer therapy: Review and update. Int Rev Immunol. 2017;36:207-219 pubmed publisher
    ..A-chain of ricin; rGel: recombinant de-glycosylated form of gelonin; NKC: natural killer cells; HTR: human transferrin receptor; EGF: epidermal growth factor; GM-CSF: granulocyte-macrophage colony-stimulating factor; DAB389: truncated ..
  15. Brindle E, Lillis L, Barney R, Hess S, Wessells K, Ouédraogo C, et al. Simultaneous assessment of iodine, iron, vitamin A, malarial antigenemia, and inflammation status biomarkers via a multiplex immunoassay method on a population of pregnant women from Niger. PLoS ONE. 2017;12:e0185868 pubmed publisher
    ..malaria biomarkers: ?-1-acid glycoprotein, C-reactive protein, ferritin, retinol binding protein 4, soluble transferrin receptor, thyroglobulin, and histidine-rich protein II...
  16. Michaelsen F, Saeed M, Schwarzkopf J, Efferth T. Activity of Artemisia annua and artemisinin derivatives, in prostate carcinoma. Phytomedicine. 2015;22:1223-31 pubmed publisher
    ..GSTP1), Ki-67, MYC, oxidized low density lipoprotein (lectin-like) receptor 1 (LOX1), p53, P-glycoprotein, transferrin receptor (TFR, CD71), vascular endothelial growth factor (VEGF), von Willebrand factor (CD31))...
  17. Geng J, Li J, Huang T, Zhao K, Chen Q, Guo W, et al. A novel manganese complex selectively induces malignant glioma cell death by targeting mitochondria. Mol Med Rep. 2016;14:1970-8 pubmed publisher
    ..As manganese (Mn) compounds can be transported by the transferrin?transferrin receptor system, the present study synthesized and examined the potential use of Adpa?Mn as a novel antitumor agent...
  18. Olajide O, Fatoye J, Idowu O, Ilekoya D, Gbadamosi I, Gbadamosi M, et al. Reversal of behavioral decline and neuropathology by a complex vitamin supplement involves modulation of key neurochemical stressors. Environ Toxicol Pharmacol. 2018;62:120-131 pubmed publisher
    ..Hypothesizing that in vivo modulation of key neurochemical processes including metal ion regulation (by transferrin receptor-1: TfR-1) in cells can improve disease outcome, we investigated the efficacy of a complex vitamin ..
  19. Gnana Prakasam J, Baldowski R, Ananth S, Martin P, Smith S, Ganapathy V. Retinal expression of the serine protease matriptase-2 (Tmprss6) and its role in retinal iron homeostasis. Mol Vis. 2014;20:561-74 pubmed
    ..iron status in Tmprss6(msk/msk) mice was evaluated by comparing the expression levels of ferritin and transferrin receptor 1 between wild-type and knockout mice...
  20. Fan C, Zhang Y, Zhou Y, Li B, He Y, Guo Y, et al. Up-regulation of A20/ABIN1 contributes to inefficient M1 macrophage polarization during Hepatitis C virus infection. Virol J. 2015;12:147 pubmed publisher
    ..a variation of functional molecules such as tumor necrosis factor-α, CD163, matrix metalloproteinases, transferrin receptor-1, and CD100, reflecting an anti-inflammatory reaction against M1-polarization...
  21. Wadajkar A, Dancy J, Hersh D, Anastasiadis P, Tran N, Woodworth G, et al. Tumor-targeted nanotherapeutics: overcoming treatment barriers for glioblastoma. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017;9: pubmed publisher
    ..Some of the key cell surface molecules that have been identified as GBM targets include the transferrin receptor, low-density lipoprotein receptor-related protein, ?v ?3 integrin, glucose ..
  22. Kühn L. Iron regulatory proteins and their role in controlling iron metabolism. Metallomics. 2015;7:232-43 pubmed publisher
    ..Foremost, IRPs regulate ferritin H and ferritin L translation and thus iron storage, as well as transferrin receptor 1 (TfR1) mRNA stability, thereby adjusting receptor expression and iron uptake via receptor-mediated ..
  23. Zhou Y, Yang Y, Liu Y, Chang H, Liu K, Zhang X, et al. Irp2 Knockout Causes Osteoporosis by Inhibition of Bone Remodeling. Calcif Tissue Int. 2019;104:70-78 pubmed publisher
    ..Posttranscriptionally decreased ferritin (FTL), ferroportin 1 (FPN1), and increased transferrin receptor 1 (TfR1) gene expressions have been unexpectedly found in bone tissue of Irp2-/- mice...
  24. Kawabata H. Transferrin and transferrin receptors update. Free Radic Biol Med. 2019;133:46-54 pubmed publisher
    ..Tf-bound iron is incorporated through Tf receptor (TfR) 1-mediated endocytosis. TfR1 can mediate cellular uptake of both Tf and H-ferritin, an iron storage protein...
  25. Przybyłowski P, Janik L, Wasilewski G, Nowak E, Koźlik P, Małyszko J. YKL-40, a novel marker of cardiovascular complications, is related to kidney function in heart transplant recipients. Transplant Proc. 2014;46:2860-3 pubmed publisher
    ..01), time after transplantation (r = 0.23; P < .05), copeptin (r = -0.42; P < .001), soluble transferrin receptor (r = 0.24; P < .05), hemoglobin (r = -0.42; P < .001), transferrin (r = -0.31; P < ...
  26. Jing S, Spencer T, Miller K, Hopkins C, Trowbridge I. Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization. J Cell Biol. 1990;110:283-94 pubmed
    ..domain deleted suggested that residues within a 10-amino acid region (amino acids 19-28) of the human transferrin receptor cytoplasmic domain are required for efficient endocytosis...
  27. Vannelli B, Orlando C, Barni T, Natali A, Serio M, Balboni G. Immunostaining of transferrin and transferrin receptor in human seminiferous tubules. Fertil Steril. 1986;45:536-41 pubmed
    Transferrin (TF) and transferrin receptor (TFr) were studied in human testicular biopsy specimens with the use of immunostaining techniques...
  28. Hiratsuka M, Ueda K, Uno N, Uno K, Fukuhara S, Kurosaki H, et al. Retargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome. BMC Biotechnol. 2015;15:58 pubmed publisher
    ..Here, we show that retargeting of microcell fusion by adding anti-Transferrin receptor (TfR) single chain antibodies (scFvs) to the extracellular C-terminus of the MV-H protein improves the ..
  29. Cheng Y, Zhou J, Li Q, Liu Y, Wang K, Zhang Y. The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing mice. Food Funct. 2016;7:1033-9 pubmed publisher
    ..to iron metabolism, the mean levels of serum hepcidin, interleukin-6 (IL-6), ferritin, transferrin (Tf), transferrin receptor 1 (TfR1) and transferrin receptor 2 (TfR2) in H22-bearing mice were promoted, and serum iron concentration ..
  30. Gaweda A. Markers of iron status in chronic kidney disease. Hemodial Int. 2017;21 Suppl 1:S21-S27 pubmed publisher
    ..content and percent hypochromic red cells (HRC), as well as experimental ones, such as hepcidin and soluble transferrin receptor (sTfR)...
  31. Matarraz S, Leoz P, Fernandez C, Colado E, Chillón M, Vidriales M, et al. Basophil-lineage commitment in acute promyelocytic leukemia predicts for severe bleeding after starting therapy. Mod Pathol. 2018;31:1318-1331 pubmed publisher
    ..007); moreover, aberrant expression of CD7, coexpression of CD34+/CD7+ and lack of CD71 was also more frequently found among patients with (mild and severe) bleeding at baseline and/or after starting ..
  32. Driskell O, Mironov A, Allan V, Woodman P. Dynein is required for receptor sorting and the morphogenesis of early endosomes. Nat Cell Biol. 2007;9:113-20 pubmed
    ..into vacuoles enriched for the small GTPase Rab5, which progressively exclude nutrient receptors, such as transferrin receptor, into neighbouring tubules...
  33. Sun L, Liao G, Gao J, Chen T, Pan L, Yuan L. [Expression of mitochondrial ferritin in K562 leukemic cell during ATRA-induced cell differentiation]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2010;41:77-80, 90 pubmed
    To investigate the expression of MtF, transferrin receptor 1 (TfR1) and ferritin (Fn) mRNAs in K562 leukemic cells during ATRA-induced cell differentiation and to explore the interrelationship between the expression levels of these iron ..
  34. Song P, Wu T, Hong M, Chen M. Elevated temperature inhibits recruitment of transferrin-positive vesicles and induces iron-deficiency genes expression in Aiptasia pulchella host-harbored Symbiodinium. Comp Biochem Physiol B Biochem Mol Biol. 2015;188:1-7 pubmed publisher
    ..Since cellular iron acquisition is known to be mediated through transferrin receptor-mediated endocytosis, a vesicular trafficking pathway specifically regulated by Rab4 and Rab5, we set out ..
  35. Basiorka A, McGraw K, De Ceuninck L, Griner L, Zhang L, Clark J, et al. Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41. Cancer Res. 2016;76:3531-40 pubmed publisher
    ..Lenalidomide upregulated expression and stability of JAK2-associated EpoR in UT7 erythroid cells and primary CD71+ erythroid progenitors...
  36. Yang A, Zhao J, Lu M, Gu Y, Zhu Y, Chen D, et al. Expression of Hepcidin and Ferroportin in the Placenta, and Ferritin and Transferrin Receptor 1 Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..The present study aimed to detect circulating soluble transferrin receptor (sTfR) and ferritin levels in maternal and umbilical cord blood...
  37. Ikuta K, Hatayama M, Addo L, Toki Y, Sasaki K, Tatsumi Y, et al. Iron overload patients with unknown etiology from national survey in Japan. Int J Hematol. 2017;105:353-360 pubmed publisher
    ..genes in 27 cases of iron overload with unknown etiology revealed mutations in the gene coding hemojuvelin, transferrin receptor 2, and ferroportin; this indicates that although rare, hereditary hemochromatosis does occur in Japan.
  38. Thapa P, Romero Arocha S, Chung J, Sant Angelo D, Shapiro V. Histone deacetylase 3 is required for iNKT cell development. Sci Rep. 2017;7:5784 pubmed publisher
    ..Interestingly, Hdac3-deficient iNKT cells also have lower expression of the nutrient receptors GLUT1, CD71 and CD98, which would increase the need for autophagy when nutrients are limiting...
  39. Horniblow R, Latunde Dada G, Harding S, Schneider M, Almutairi F, Sahni M, et al. The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health. Mol Nutr Food Res. 2016;60:2098-108 pubmed publisher
    ..tested was able to inhibit intracellular iron accumulation as assessed by iron-mediated ferritin induction, transferrin receptor expression, intracellular (59) Fe concentrations, and iron flux across a Caco-2 monolayer...
  40. Blagojević Zagorac G, Mahmutefendić H, Macesic S, Karleuša L, Lucin P. Quantitative Analysis of Endocytic Recycling of Membrane Proteins by Monoclonal Antibody-Based Recycling Assays. J Cell Physiol. 2017;232:463-476 pubmed publisher
    ..recycling of membrane proteins that are internalized by clathrin-dependent endocytosis, represented by the transferrin receptor, and by clathrin-independent endocytosis, represented by the Major Histocompatibility Class I molecules...
  41. Mahon F. Discontinuation of TKI therapy and 'functional' cure for CML. Best Pract Res Clin Haematol. 2016;29:308-313 pubmed publisher
    ..follow-up which allowed defining a new criterion of clinical outcome evaluation, the treatment free remission (TFR)...
  42. Wymant J, Hiscox S, Westwell A, Urbé S, Clague M, Jones A. The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer. J Cancer. 2016;7:2388-2407 pubmed
    ..Levels of transferrin receptor and the uptake of transferrin were unaltered by over-expression of BCA2 indicating that trafficking changes ..
  43. Gu J, Al Bayati K, Ho E. Development of antibody-modified chitosan nanoparticles for the targeted delivery of siRNA across the blood-brain barrier as a strategy for inhibiting HIV replication in astrocytes. Drug Deliv Transl Res. 2017;7:497-506 pubmed publisher
    ..We hypothesized that transferrin antibody and bradykinin B2 antibody could specifically bind to the transferrin receptor (TfR) and bradykinin B2 receptor (B2R), respectively, and deliver siRNA across the BBB into astrocytes as ..
  44. Hu Y, Li A, Xu Y, Jiang B, Lu G, Luo X. Transcriptomic variation of locally-infected skin of Epinephelus coioides reveals the mucosal immune mechanism against Cryptocaryon irritans. Fish Shellfish Immunol. 2017;66:398-410 pubmed publisher
    ..Innate immune molecules, including hepcidin, C-type lectin, transferrin, transferrin receptor protein, serum amyloid A, cathepsin and complement components were significantly up-regulated (fold-change ..
  45. Altamura S, Kopf S, Schmidt J, Müdder K, da Silva A, Nawroth P, et al. Uncoupled iron homeostasis in type 2 diabetes mellitus. J Mol Med (Berl). 2017;95:1387-1398 pubmed publisher
    ..db/db mice show an overall hepatic iron deficiency despite unaltered expression of ferritin and the iron importer TfR1. In addition, the liver correctly senses increased circulating iron levels by activating the BMP/SMAD signaling ..
  46. Cox H, Miller G, Lai A, Cushman D, Eichner D. Detection of autologous blood transfusions using a novel dried blood spot method. Drug Test Anal. 2017;9:1713-1720 pubmed publisher
    ..Two proteins, CD71 and Band3, are measured to count IRC and RBC, respectively...
  47. Levy J, Jin O, Fujiwara Y, Kuo F, Andrews N. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet. 1999;21:396-9 pubmed
    ..Diferric Trf interacts with cell-surface Trf receptor (Trfr) to undergo receptor-mediated endocytosis into specialized endosomes...
  48. Lamoril J, Andant C, Gouya L, Malonova E, Grandchamp B, Martasek P, et al. Hemochromatosis (HFE) and transferrin receptor-1 (TFRC1) genes in sporadic porphyria cutanea tarda (sPCT). Cell Mol Biol (Noisy-le-grand). 2002;48:33-41 pubmed
    ..S65C, C282Y), and in a case control study we searched for an association between sPCT and the human transferrin receptor-1 (TFRC1) gene whose product is thought to be in functional association with the HFE protein: three single ..
  49. Dhungana S, Taboy C, Zak O, Larvie M, Crumbliss A, Aisen P. Redox properties of human transferrin bound to its receptor. Biochemistry. 2004;43:205-9 pubmed
    ..In its iron-donating cycle, transferrin is first captured by the transferrin receptor on the cell membrane, and then internalized to a proton-pumping endosome where iron is released...
  50. Ohkuma M, Haraguchi N, Ishii H, Mimori K, Tanaka F, Kim H, et al. Absence of CD71 transferrin receptor characterizes human gastric adenosquamous carcinoma stem cells. Ann Surg Oncol. 2012;19:1357-64 pubmed publisher
    ..Changes in expression of CD44, CD49f, CD133, and CD71 following 5-fluorouracil (5-FU) treatment were assessed...
  51. Perez Bay A, Schreiner R, Benedicto I, Paz Marzolo M, Banfelder J, Weinstein A, et al. The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells. Nat Commun. 2016;7:11550 pubmed publisher
    ..recycling and transcytotic pathways of epithelial cells were previously defined using markers such as transferrin (TfR) and polymeric IgA (pIgR) receptors. In contrast, our knowledge of the apical recycling pathway remains fragmentary...
  52. Vaeth M, Eckstein M, Shaw P, Kozhaya L, Yang J, Berberich Siebelt F, et al. Store-Operated Ca(2+) Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity. Immunity. 2016;44:1350-64 pubmed publisher
    ..Tfh) cells promote affinity maturation of B cells in germinal centers (GCs), whereas T follicular regulatory (Tfr) cells limit the GC reaction...
  53. Xie Y, Killinger B, Moszczynska A, Merkel O. Targeted Delivery of siRNA to Transferrin Receptor Overexpressing Tumor Cells via Peptide Modified Polyethylenimine. Molecules. 2016;21: pubmed
    ..However, siRNA cancer therapies are hindered by poor delivery of siRNA to cancer cells. Transferrin receptor (TfR) is overexpressed in many types of tumor cells and therefore is a potential target for the selective ..
  54. Schümann K, Solomons N. Perspective: What Makes It So Difficult to Mitigate Worldwide Anemia Prevalence?. Adv Nutr. 2017;8:401-408 pubmed publisher
    ..Some of them are well established in adults [e.g., concentrations of serum ferritin, soluble transferrin receptor (sTfR), and serum iron or the ratio of sTfR to log ferritin]...
  55. Rappaport A, Whitfield K, Chapman G, Yada R, Kheang K, Louise J, et al. Randomized controlled trial assessing the efficacy of a reusable fish-shaped iron ingot to increase hemoglobin concentration in anemic, rural Cambodian women. Am J Clin Nutr. 2017;106:667-674 pubmed publisher
    ..Blood was analyzed for hemoglobin, serum ferritin, and serum transferrin receptor. Hemoglobin electrophoresis was used to detect structural hemoglobin variants...
  56. Doudin A, Becker A, Rothenberger A, Meyer T. Relationship between serum 25-hydroxyvitamin D and red blood cell indices in German adolescents. Eur J Pediatr. 2018;177:583-591 pubmed publisher
    ..11, p < 0.001), red blood cell count (r = - 0.04, p = 0.002), and soluble transferrin receptor (r = - 0.1, p < 0...
  57. Hayes G, Enns C, Lucas J. Identification of the O-linked glycosylation site of the human transferrin receptor. Glycobiology. 1992;2:355-9 pubmed
    The human transferrin receptor is a glycoprotein containing three N-linked and one O-linked glycosylation sites...
  58. Webster P, Vanacore L, Nairn A, Marino C. Subcellular localization of CFTR to endosomes in a ductal epithelium. Am J Physiol. 1994;267:C340-8 pubmed
    ..In this preparation, some of the CFTR-labeled vesicles were also labeled with antibodies against transferrin receptor and rab4, two markers of early endosomes and receptor-mediated endocytosis...
  59. Zhang J, He J, Zeng X, Su J, Chen H, Xu Y, et al. [Gene Mutation Spectrum of β-Thalassemia in Dai Ethinic Population of Two Border Region in Chinese Yunnan Province]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:157-61 pubmed publisher
    ..56%), CD41-42 (18.97%), CD17 (14.36%), CD71-72 (2.05%) and IVS-II-654 (1.54%)...
  60. Agrawal P, Singh R, Sonali -, Kumari L, Sharma G, Koch B, et al. TPGS-chitosan cross-linked targeted nanoparticles for effective brain cancer therapy. Mater Sci Eng C Mater Biol Appl. 2017;74:167-176 pubmed publisher
    Brain cancer, up-regulated with transferrin receptor led to concept of transferrin receptor targeted anticancer therapeutics...
  61. Pellegrino R, Riondato F, Ferbo L, Boero M, Palmieri A, Osella L, et al. Altered Erythropoiesis in Mouse Models of Type 3 Hemochromatosis. Biomed Res Int. 2017;2017:2408941 pubmed publisher
    ..HFE3 is caused by mutations in transferrin receptor 2 (TFR2) gene that codes for two main isoforms (Tfr2α and Tfr2β)...
  62. Mischler R, Armah S, Craig B, Rosen A, Banerjee A, Selzer D, et al. Comparison of Oral Iron Supplement Formulations for Normalization of Iron Status Following Roux-EN-y Gastric Bypass Surgery: a Randomized Trial. Obes Surg. 2018;28:369-377 pubmed publisher
    ..5 mg/day) for 8 weeks. Measures of iron status, including blood concentrations of ferritin, soluble transferrin receptor (sTfR), and hemoglobin, were assessed...
  63. Kaup M, Dassler K, Weise C, Fuchs H. Shedding of the transferrin receptor is mediated constitutively by an integral membrane metalloprotease sensitive to tumor necrosis factor alpha protease inhibitor-2. J Biol Chem. 2002;277:38494-502 pubmed
    The transferrin receptor (TfR) is a transmembrane protein that mediates cellular uptake of iron...
  64. Jacob A, Singh R, Mohammad F, Bebee T, Chandler D. The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA. J Biol Chem. 2014;289:17350-64 pubmed publisher
    ..These findings are the first report describing the regulation of alternative splicing of MDM2 mediated by the oncogenic factor FUBP1. ..
  65. Barker M, Henderson A, Naguib K, Vercauteren S, Devlin A, Albert A, et al. Serum Soluble Transferrin Receptor Concentrations Are Elevated in Congolese Children with Glucose-6-Phosphate Dehydrogenase Variants, but Not Sickle Cell Variants or ?-Thalassemia. J Nutr. 2017;147:1785-1794 pubmed publisher
    ..aimed to measure the associations between inherited blood disorders and hemoglobin, ferritin, and soluble transferrin receptor (sTfR) concentrations in Congolese children...
  66. Goswami T, Andrews N. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. J Biol Chem. 2006;281:28494-8 pubmed
    HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human hereditary hemochromatosis...
  67. Vicente R, Villalonga N, Calvo M, Escalada A, Solsona C, Soler C, et al. Kv1.5 association modifies Kv1.3 traffic and membrane localization. J Biol Chem. 2008;283:8756-64 pubmed publisher
    ..3 and Kv1.5 targeting to rafts. Our results implicate the traffic and localization of Kv1.3/Kv1.5 heteromers in the complex regulation of immune system cells. ..
  68. Clements A, Stoneham C, Furniss R, Frankel G. Enterohaemorrhagic Escherichia coli inhibits recycling endosome function and trafficking of surface receptors. Cell Microbiol. 2014;16:1693-705 pubmed publisher
    ..In particular, we found that following transferrin binding and endocytosis EspG reduces recycling of the transferrin receptor (TfR), the prototypical recycling protein, from an intracellular location to the cell surface, resulting in ..
  69. Kindrat I, Tryndyak V, de Conti A, Shpyleva S, Mudalige T, Kobets T, et al. MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis. Oncotarget. 2016;7:1276-87 pubmed publisher
    Over-expression of transferrin receptor 1 (TFRC) is observed in hepatocellular carcinoma (HCC); however, there is a lack of conclusive information regarding the mechanisms of this dysregulation...
  70. Peterson R, Wilund K, Cunningham B, Andrade J. Comparison of Methods Study between a Photonic Crystal Biosensor and Certified ELISA to Measure Biomarkers of Iron Deficiency in Chronic Kidney Disease Patients. Sensors (Basel). 2017;17: pubmed publisher
    The total analytical error of a photonic crystal (PC) biosensor in the determination of ferritin and soluble transferrin receptor (sTfR) as biomarkers of iron deficiency anemia in chronic kidney disease (CKD) patients was evaluated ..
  71. Hemadi M, Kahn P, Miquel G, El Hage Chahine J. Transferrin's mechanism of interaction with receptor 1. Biochemistry. 2004;43:1736-45 pubmed
    The kinetics and thermodynamics of the interactions of transferrin receptor 1 with holotransferrin and apotransferrin in neutral and mildly acidic media are investigated at 37 degrees C in the presence of CHAPS micelles...
  72. Li Y, Yu P, Chang S, Wu Q, Yu P, Xie C, et al. Hypobaric Hypoxia Regulates Brain Iron Homeostasis in Rats. J Cell Biochem. 2017;118:1596-1605 pubmed publisher
    ..The expression levels of iron storage protein L-ferritin and iron transport proteins, including transferrin receptor-1 (TfR1), divalent metal transporter 1 (DMT1), and ferroportin1 (FPN1), were also altered...
  73. Zackova Suchanova J, Neburkova J, Spanielová H, Forstova J, Cigler P. Retargeting Polyomavirus-Like Particles to Cancer Cells by Chemical Modification of Capsid Surface. Bioconjug Chem. 2017;28:307-313 pubmed publisher
    ..we describe a chemical approach to retarget PVLPs to cancer cells displaying abnormally high levels of transferrin receptor. We created an array of transferrin molecules on the surface of PVLPs by combining a high-yielding ..
  74. Ranalli A, Santi M, Capriotti L, Voliani V, Porciani D, Beltram F, et al. Peptide-Based Stealth Nanoparticles for Targeted and pH-Triggered Delivery. Bioconjug Chem. 2017;28:627-635 pubmed publisher
    ..Upon derivatization with an anti-transferrin receptor aptamer, these vesicles show highly selective cellular internalization with minimal nonspecific uptake and ..
  75. Cobb D, Kim O, Golden Mason L, Rosen H, Hahn Y. Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection. Hepatology. 2017;: pubmed publisher
    ..T follicular regulatory (Tfr) cells are a subset of regulatory T cells that suppress T follicular helper (Tfh) cells and the generation of high ..
  76. Delos Santos R, Bautista S, Lucarelli S, Bone L, Dayam R, Abousawan J, et al. Selective regulation of clathrin-mediated epidermal growth factor receptor signaling and endocytosis by phospholipase C and calcium. Mol Biol Cell. 2017;28:2802-2818 pubmed publisher
    ..Each of these manipulations was without effect on the clathrin-mediated endocytosis of transferrin receptor (TfR). EGFR and TfR were recruited to largely distinct clathrin structures...
  77. Baynes R, Shih Y, Hudson B, Cook J. Characterization of transferrin receptor released by K562 erythroleukemia cells. Proc Soc Exp Biol Med. 1991;197:416-23 pubmed
    A soluble form of transferrin receptor has been detected in human serum and has been shown recently to be a truncated form of the intact membrane bound receptor...
  78. Sobotka T. POST-TRANSITIONAL FERTILITY: THE ROLE OF CHILDBEARING POSTPONEMENT IN FUELLING THE SHIFT TO LOW AND UNSTABLE FERTILITY LEVELS. J Biosoc Sci. 2017;49:S20-S45 pubmed publisher
    ..In many countries in Europe this shift to a late childbearing pattern has negatively affected the TFR for more than four decades...
  79. Holloway K, Sade H, Romero I, Male D. Action of transcription factors in the control of transferrin receptor expression in human brain endothelium. J Mol Biol. 2007;365:1271-84 pubmed
    Brain endothelium has a distinctive phenotype, including high expression of transferrin receptor, p-glycoprotein, claudin-5 and occludin...
  80. Traer C, Rutherford A, Palmer K, Wassmer T, Oakley J, Attar N, et al. SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment. Nat Cell Biol. 2007;9:1370-80 pubmed
    ..Suppression of SNX4 perturbs transport between these compartments and causes lysosomal degradation of the transferrin receptor (TfnR)...
  81. Dorak M, Mackay R, Relton C, Worwood M, Parker L, Hall A. Hereditary hemochromatosis gene (HFE) variants are associated with birth weight and childhood leukemia risk. Pediatr Blood Cancer. 2009;53:1242-8 pubmed publisher
    ..Gender-specific use of iron during fetal growth may lead to this dichotomy in birth weight change. Only the materno-fetal genotype combinations that increase iron levels most extremely correlated with birth weight and ALL risk in males. ..
  82. Roldán J, Martínez M, Forlenza M, Whittaker G, Candurra N. Human transferrin receptor triggers an alternative Tacaribe virus internalization pathway. Arch Virol. 2016;161:353-63 pubmed publisher
    ..In cells lacking the human transferrin receptor (hTfR), compounds and DN proteins that impair clathrin-mediated endocytosis were shown to reduce virus ..
  83. Xu L, Huang Q, Wang H, Hao Y, Bai Q, Hu J, et al. The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells. Immunity. 2017;47:538-551.e5 pubmed publisher
    Follicular regulatory T (Tfr) cells differentiate from conventional regulatory T (Treg) cells and suppress excessive germinal center (GC) responses by acting on both GC B cells and T follicular helper (Tfh) cells...
  84. Miller Y, Jones C, Scoggin C, Morse H, Seligman P. Chromosome 3q (22-ter) encodes the human transferrin receptor. Am J Hum Genet. 1983;35:573-83 pubmed
    The human transferrin receptor is an integral membrane glycoprotein of 180,000 molecular weight (mol. wt.) formed from two subunits of 90,000 mol. wt...
  85. Zalata A, Hafez T, Schoonjans F, Comhaire F. The possible meaning of transferrin and its soluble receptors in seminal plasma as markers of the seminiferous epithelium. Hum Reprod. 1996;11:761-4 pubmed
    ..Further investigations are needed to assess its usefulness for clinical practice. ..
  86. Qian Z, Xiao D, Tang P, Yao F, Liao Q. Increased expression of transferrin receptor on membrane of erythroblasts in strenuously exercised rats. J Appl Physiol (1985). 1999;87:523-9 pubmed
    This study investigated the effects of strenuous exercise on transferrin (Tf)-receptor (TfR) expression and Tf-bound iron (Tf-Fe) uptake in erythroblasts of rat bone marrow...
  87. Shimosaki S, Nakahata S, Ichikawa T, Kitanaka A, Kameda T, Hidaka T, et al. Development of a complete human IgG monoclonal antibody to transferrin receptor 1 targeted for adult T-cell leukemia/lymphoma. Biochem Biophys Res Commun. 2017;485:144-151 pubmed publisher
    ..adult T-cell leukemia/lymphoma (ATLL) has no effective therapy and high levels of cell surface transferrin receptor 1 (TFR1) expression have been reported in ATLL by us and other groups...
  88. Evans P, Kemp J. Exon/intron structure of the human transferrin receptor gene. Gene. 1997;199:123-31 pubmed
    A PCR-based intron jumping strategy has been utilized to investigate the exon/intron structure of the human transferrin receptor gene and determine the sequences of exon/intron junctions...
  89. Borrow P, Moody M. Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies. Immunol Rev. 2017;275:62-78 pubmed publisher
    ..memory B cells and plasma cells, while regulatory CD4+ (Treg) cells including T follicular regulatory (Tfr) cells inhibit the germinal center reaction to limit autoantibody production...
  90. Moura I, Arcos Fajardo M, Gdoura A, Leroy V, Sadaka C, Mahlaoui N, et al. Engagement of transferrin receptor by polymeric IgA1: evidence for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy. J Am Soc Nephrol. 2005;16:2667-76 pubmed
    ..The transferrin receptor (TfR) was identified previously as an IgA1 receptor, and it was found that, in biopsies of patients with ..
  91. Habashy H, Powe D, Staka C, Rakha E, Ball G, Green A, et al. Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen. Breast Cancer Res Treat. 2010;119:283-93 pubmed publisher
    b>Transferrin receptor (CD71) is involved in the cellular uptake of iron and is expressed on cells with high proliferation. It may be implicated in promoting the growth of endocrine resistant phenotypes within ER+/luminal-like breast cancer...
  92. Benyamin B, Esko T, Ried J, Radhakrishnan A, Vermeulen S, Traglia M, et al. Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nat Commun. 2014;5:4926 pubmed publisher
    ..There is substantial overlap between our iron loci and loci affecting erythrocyte and lipid phenotypes. These results will facilitate investigation of the roles of iron in disease. ..