transferrin

Summary

Gene Symbol: transferrin
Description: transferrin
Alias: HEL-S-71p, PRO1557, PRO2086, TFQTL1, serotransferrin, beta-1 metal-binding globulin, epididymis secretory sperm binding protein Li 71p, siderophilin
Species: human
Products:     transferrin

Top Publications

  1. Park S, Hu H, Wright R, Schwartz J, Cheng Y, Sparrow D, et al. Iron metabolism genes, low-level lead exposure, and QT interval. Environ Health Perspect. 2009;117:80-5 pubmed publisher
    ..oxidative effects of lead, we examined whether polymorphisms in iron metabolism genes [hemochromatosis (HFE), transferrin (TF) C2, and heme oxygenase-1 (HMOX-1)] increase susceptibility to the effects of lead on QT interval in 613 ..
  2. Bartzokis G, Lu P, Tishler T, Peters D, Kosenko A, Barrall K, et al. Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older men. J Alzheimers Dis. 2010;20:333-41 pubmed publisher
    Prevalent gene variants involved in iron metabolism [hemochromatosis (HFE) H63D and transferrin C2 (TfC2)] have been associated with higher risk and earlier age at onset of Alzheimer's disease (AD), especially in men...
  3. Zhang P, Yang Z, Zhang C, Lu Z, Shi X, Zheng W, et al. Association study between late-onset Alzheimer's disease and the transferrin gene polymorphisms in Chinese. Neurosci Lett. 2003;349:209-11 pubmed
    To investigate the possible involvement of the transferrin (TF) gene polymorphism in the manifestation of Alzheimer's disease (AD), we analyzed the TF and apolipoprotein E (APOE) genotypes of 67 sporadic late-onset AD patients and 131 ..
  4. Paez P, Marta C, Moreno M, Soto E, Pasquini J. Apotransferrin decreases migration and enhances differentiation of oligodendroglial progenitor cells in an in vitro system. Dev Neurosci. 2002;24:47-58 pubmed
    ..This effect was not observed when an antibody against the transferrin receptor was added...
  5. Bartzokis G, Lu P, Tingus K, Peters D, Amar C, Tishler T, et al. Gender and iron genes may modify associations between brain iron and memory in healthy aging. Neuropsychopharmacology. 2011;36:1375-84 pubmed publisher
    ..prevalent allelic variants in genes encoding for iron metabolism proteins (hemochromatosis H63D (HFE H63D) and transferrin C2 (TfC2))...
  6. Duguid J, Bohmont C, Liu N, Tourtellotte W. Changes in brain gene expression shared by scrapie and Alzheimer disease. Proc Natl Acad Sci U S A. 1989;86:7260-4 pubmed
    ..DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease ..
  7. Gruper Y, Bar J, Bacharach E, Ehrlich R. Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells. J Cell Physiol. 2005;204:901-12 pubmed
    ..Based on previous and these data we suggest that the level of intracellular iron may regulate both TfR expression (on the post-transcriptional and the post-translational levels) and TfR trafficking/transcytosis in polarized cells. ..
  8. Robson K, Lehmann D, Wimhurst V, Livesey K, Combrinck M, Merryweather Clarke A, et al. Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease. J Med Genet. 2004;41:261-5 pubmed
    ..We have examined the interaction between the C2 variant of the transferrin (TF) gene and the C282Y allele of the haemochromatosis (HFE) gene as risk factors for developing AD...
  9. Lebron J, Bennett M, Vaughn D, Chirino A, Snow P, Mintier G, et al. Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell. 1998;93:111-23 pubmed
    ..HFE binds to transferrin receptor (TfR) and reduces its affinity for iron-loaded transferrin, implicating HFE in iron metabolism. The 2...

More Information

Publications85

  1. Enns C, Sussman H. Physical characterization of the transferrin receptor in human placentae. J Biol Chem. 1981;256:9820-3 pubmed
    The physical properties and binding characteristics of the solubilized transferrin receptor isolated from the placental brush-border membrane of a human trophoblast cell were investigated...
  2. Herbison C, Thorstensen K, Chua A, Graham R, Leedman P, Olynyk J, et al. The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells. Am J Physiol Cell Physiol. 2009;297:C1567-75 pubmed publisher
    b>Transferrin receptor (TFR) 1 and 2 are expressed in the liver; TFR1 levels are regulated by cellular iron levels while TFR2 levels are regulated by transferrin saturation...
  3. Sarria B, Navas Carretero S, Lopez Parra A, Perez Granados A, Arroyo Pardo E, Roe M, et al. The G277S transferrin mutation does not affect iron absorption in iron deficient women. Eur J Nutr. 2007;46:57-60 pubmed
    ..The G277S transferrin mutation has been implicated as a risk factor for iron deficiency in menstruating women...
  4. Liu R, Guan J, Zak O, Aisen P, Chance M. Structural reorganization of the transferrin C-lobe and transferrin receptor upon complex formation: the C-lobe binds to the receptor helical domain. Biochemistry. 2003;42:12447-54 pubmed
    Human transferrin, a bilobal protein, with each lobe bearing a single iron-binding site, functions to transport iron into cells...
  5. Campo G, Valgimigli M, Ferraresi P, Malagutti P, Baroni M, Arcozzi C, et al. Tissue factor and coagulation factor VII levels during acute myocardial infarction: association with genotype and adverse events. Arterioscler Thromb Vasc Biol. 2006;26:2800-6 pubmed
    ..Admission FVII and TF antigen levels, partially predicted by polymorphisms, are independent predictors of mortality and reinfarction in patients with acute MI. ..
  6. Laumet G, Chouraki V, Grenier Boley B, Legry V, Heath S, Zelenika D, et al. Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study. J Alzheimers Dis. 2010;20:1181-8 pubmed publisher
    ..Of the genes showing nominal association in our cohorts, TFAM and CHRNB2 appear particularly interesting and warrant further genetic and functional follow-up analyses. ..
  7. Kauwe J, Bertelsen S, Mayo K, Cruchaga C, Abraham R, Hollingworth P, et al. Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:955-9 pubmed publisher
    ..2004); J Med Genet 41:261-265] reported that epistatic interaction between rs1049296 (P589S) in the transferrin gene (TF) and rs1800562 (C282Y) in the hemochromatosis gene (HFE) results in significant association with risk ..
  8. Hopkins M, Ettinger A, Hernandez Avila M, Schwartz J, Tellez Rojo M, Lamadrid Figueroa H, et al. Variants in iron metabolism genes predict higher blood lead levels in young children. Environ Health Perspect. 2008;116:1261-6 pubmed publisher
    ..We examined the association between common missense variants in the hemochromatosis (HFE) and transferrin (TF) genes and blood lead levels in 422 Mexican children...
  9. Schjeide B, McQueen M, Mullin K, DiVito J, Hogan M, Parkinson M, et al. Assessment of Alzheimer's disease case-control associations using family-based methods. Neurogenetics. 2009;10:19-25 pubmed publisher
    ..Further fine-mapping and functional analyses are warranted to elucidate the potential biochemical mechanisms and epidemiological relevance of these genes. ..
  10. Cheng Y, Zak O, Aisen P, Harrison S, Walz T. Structure of the human transferrin receptor-transferrin complex. Cell. 2004;116:565-76 pubmed
    Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR)...
  11. Jahanshad N, Kohannim O, Hibar D, Stein J, McMahon K, de Zubicaray G, et al. Brain structure in healthy adults is related to serum transferrin and the H63D polymorphism in the HFE gene. Proc Natl Acad Sci U S A. 2012;109:E851-9 pubmed publisher
    ..Specific genetic markers have been previously identified that influence levels of transferrin, the protein that transports iron throughout the body, in the blood and brain...
  12. Lee P, Halloran C, Trevino R, Felitti V, Beutler E. Human transferrin G277S mutation: a risk factor for iron deficiency anaemia. Br J Haematol. 2001;115:329-33 pubmed
    Numerous polymorphisms of the transferrin gene result in a range of electrophoretic variants. We show that one of these mutations has a functional consequence...
  13. West A, Giannetti A, Herr A, Bennett M, Nangiana J, Pierce J, et al. Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites. J Mol Biol. 2001;313:385-97 pubmed
    The transferrin receptor (TfR) binds two proteins critical for iron metabolism: transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis...
  14. Sakajiri T, Yamamura T, Kikuchi T, Yajima H. Computational structure models of apo and diferric transferrin-transferrin receptor complexes. Protein J. 2009;28:407-14 pubmed publisher
    Complexation of transferrin (Tf) and its receptor (TfR) is an essential event for iron uptake by the cell. Much data has been accumulated regarding Tf-TfR complexation, such as results from mutagenesis...
  15. Wysokinski D, Danisz K, Blasiak J, Dorecka M, Romaniuk D, Szaflik J, et al. An association of transferrin gene polymorphism and serum transferrin levels with age-related macular degeneration. Exp Eye Res. 2013;106:14-23 pubmed publisher
    ..In the present work we investigated the association between four polymorphisms of the transferrin gene (rs8177178; rs8177179; rs4481157; rs1130459) and AMD in dependence on the transferrin protein and iron ..
  16. Adams T, Mason A, He Q, Halbrooks P, Briggs S, Smith V, et al. The position of arginine 124 controls the rate of iron release from the N-lobe of human serum transferrin. A structural study. J Biol Chem. 2003;278:6027-33 pubmed
    Human serum transferrin (hTF) is a bilobal iron-binding and transport protein that carries iron in the blood stream for delivery to cells by a pH-dependent mechanism...
  17. Namekata K, Oyama F, Imagawa M, Ihara Y. Human transferrin (Tf): a single mutation at codon 570 determines Tf C1 or Tf C2 variant. Hum Genet. 1997;100:457-8 pubmed
    b>Transferrin (Tf) has many variants, as revealed by isoelectric focusing (IEF)...
  18. Benyamin B, McRae A, Zhu G, Gordon S, Henders A, Palotie A, et al. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. Am J Hum Genet. 2009;84:60-5 pubmed publisher
    ..We report the results from two GWASs for serum markers of iron status (serum iron, serum transferrin, transferrin saturation with iron, and serum ferritin), which are important in iron overload (e.g...
  19. Eckenroth B, Steere A, Chasteen N, Everse S, Mason A. How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH. Proc Natl Acad Sci U S A. 2011;108:13089-94 pubmed publisher
    Delivery of iron to cells requires binding of two iron-containing human transferrin (hTF) molecules to the specific homodimeric transferrin receptor (TFR) on the cell surface...
  20. de Arriba Zerpa G, Saleh M, Fernandez P, Guillou F, Espinosa de los Monteros A, de Vellis J, et al. Alternative splicing prevents transferrin secretion during differentiation of a human oligodendrocyte cell line. J Neurosci Res. 2000;61:388-95 pubmed
    b>Transferrin, the iron-transport protein of vertebrate serum, is synthesized mainly in the liver, from which it is secreted into the blood...
  21. Mujika J, Escribano B, Akhmatskaya E, Ugalde J, Lopez X. Molecular dynamics simulations of iron- and aluminum-loaded serum transferrin: protonation of Tyr188 is necessary to prompt metal release. Biochemistry. 2012;51:7017-27 pubmed publisher
    Serum transferrin (sTf) carries iron in blood serum and delivers it into cells by receptor-mediated endocytosis. The protein can also bind other metals, including aluminum...
  22. Paez P, Garcia C, Davio C, Campagnoni A, Soto E, Pasquini J. Apotransferrin promotes the differentiation of two oligodendroglial cell lines. Glia. 2004;46:207-17 pubmed
    ..The results suggest that aTf can influence OLGc gene expression and differentiation through multiple mechanisms depending on the maturation of the cell. ..
  23. Steere A, Roberts S, Byrne S, Dennis Chasteen N, Bobst C, Kaltashov I, et al. Properties of a homogeneous C-lobe prepared by introduction of a TEV cleavage site between the lobes of human transferrin. Protein Expr Purif. 2010;72:32-41 pubmed publisher
    Essential to iron transport and delivery, human serum transferrin (hTF) is a bilobal glycoprotein capable of reversibly binding one ferric ion in each lobe (the N- and C-lobes)...
  24. Feder J, Penny D, Irrinki A, Lee V, Lebron J, Watson N, et al. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci U S A. 1998;95:1472-7 pubmed
    ..wild-type or mutant HFE proteins that both the wild-type and H63D HFE proteins form stable complexes with the transferrin receptor (TfR)...
  25. Jeffrey P, Bewley M, MacGillivray R, Mason A, Woodworth R, Baker E. Ligand-induced conformational change in transferrins: crystal structure of the open form of the N-terminal half-molecule of human transferrin. Biochemistry. 1998;37:13978-86 pubmed
    Serum transferrin binds ferric ions in the bloodstream and transports them to cells, where they are released in a process involving receptor-mediated endocytosis...
  26. Pena E, Arderiu G, Badimon L. Subcellular localization of tissue factor and human coronary artery smooth muscle cell migration. J Thromb Haemost. 2012;10:2373-82 pubmed publisher
    ..These results extend the functional role of TF to smooth muscle cell trafficking in vessel wall remodeling. ..
  27. Noinaj N, Easley N, Oke M, Mizuno N, Gumbart J, Boura E, et al. Structural basis for iron piracy by pathogenic Neisseria. Nature. 2012;483:53-8 pubmed publisher
    ..Neisseria require iron for survival and can extract it directly from human transferrin for transport across the outer membrane...
  28. Maeno N, Takahashi N, Saito S, Ji X, Branko A, Ishihara R, et al. Association study between the transferrin gene and schizophrenia in the Japanese population. Neuroreport. 2007;18:517-20 pubmed
    ..Of myelin and oligodendrocyte-related genes, a significant decrease in the mRNA levels of transferrin in schizophrenics has been reported by both microarray and quantitative polymerase chain reaction studies...
  29. Ndonwi M, Broze G, Bajaj S. The first epidermal growth factor-like domains of factor Xa and factor IXa are important for the activation of the factor VII--tissue factor complex. J Thromb Haemost. 2005;3:112-8 pubmed
    ..We conclude that the EGF1 domains of FXa and FIXa are important for the activation of FVII-TF and for the formation of FVIIa-TF-FXa-TFPI complex. ..
  30. Qu M, Yue W, Tang F, Wang L, Han Y, Zhang D. Polymorphisms of Transferrin gene are associated with schizophrenia in Chinese Han population. J Psychiatr Res. 2008;42:877-83 pubmed
    ..b>Transferrin (TF), an iron transport glycoprotein playing an important role in synthesis of myelin and the development of ..
  31. Lederman M, Obolensky A, Grunin M, Banin E, Chowers I. Retinal function and structure in the hypotransferrinemic mouse. Invest Ophthalmol Vis Sci. 2012;53:605-12 pubmed publisher
    The iron carrier transferrin is expressed at remarkably high levels in normal retinas and is upregulated during retinal degeneration...
  32. Bergström J, Helander A. Influence of alcohol use, ethnicity, age, gender, BMI and smoking on the serum transferrin glycoform pattern: implications for use of carbohydrate-deficient transferrin (CDT) as alcohol biomarker. Clin Chim Acta. 2008;388:59-67 pubmed
    An alcohol-induced change in the serum transferrin glycoform pattern, carbohydrate-deficient transferrin (CDT), is used as a biomarker for detection and follow-up of heavy alcohol consumption...
  33. Byrne S, Steere A, Chasteen N, Mason A. Identification of a kinetically significant anion binding (KISAB) site in the N-lobe of human serum transferrin. Biochemistry. 2010;49:4200-7 pubmed publisher
    Human serum transferrin (hTF) binds two ferric iron ions which are delivered to cells in a transferrin receptor (TFR) mediated process...
  34. Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, et al. A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis. J Biol Chem. 2004;279:40091-9 pubmed
    ..COS cells expressing enhanced green fluorescent protein-tagged FBP17 were incubated with fluorescently labeled transferrin, epidermal growth factor, and cholera toxin, these molecules co-localized with FBP17-induced tubular ..
  35. Beaumont Epinette M, Delobel J, Ropert M, Deugnier Y, Loréal O, Jouanolle A, et al. Hereditary hypotransferrinemia can lead to elevated transferrin saturation and, when associated to HFE or HAMP mutations, to iron overload. Blood Cells Mol Dis. 2015;54:151-4 pubmed publisher
    ..We, here, report 16 cases of hereditary hypotransferrinemia related to 4 previously undescribed TF (transferrin) mutations (p.Val221Gly, p.Arg609Trp, p.Glu370Lys, p.Tyr533X and p.Cys421Arg)...
  36. Maruyama K, Morishita E, Yuno T, Sekiya A, Asakura H, Ohtake S, et al. Carbon monoxide (CO)-releasing molecule-derived CO regulates tissue factor and plasminogen activator inhibitor type 1 in human endothelial cells. Thromb Res. 2012;130:e188-93 pubmed publisher
    ..CORM-2 suppresses LPS-induced TF up-regulation in PBMCs. Therefore, we envision that the antithrombotic activity of CORM-2 might be used as a pharmaceutical agent for the treatment of various inflammatory conditions. ..
  37. Poli M, Luscieti S, Gandini V, Maccarinelli F, Finazzi D, Silvestri L, et al. Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation. Haematologica. 2010;95:1832-40 pubmed publisher
    ..of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2. However, the role of these proteins in the regulation of hepcidin expression is unclear...
  38. Buretic Tomljanovic A, Vraneković J, Rubesa G, Jonovska S, Tomljanović D, Sendula Jengić V, et al. HFE mutations and transferrin C1/C2 polymorphism among Croatian patients with schizophrenia and schizoaffective disorder. Mol Biol Rep. 2012;39:2253-8 pubmed publisher
    ..this study was to investigate the possible influence of hemochromatosis gene mutations (HFE-C282Y and H63D) and transferrin gene C2 variant (TF-C2) on susceptibility to schizophrenia and schizoaffective disorder and/or age at first ..
  39. Xinhan L, Matsushita M, Numaza M, Taguchi A, Mitsui K, Kanazawa H. Na+/H+ exchanger isoform 6 (NHE6/SLC9A6) is involved in clathrin-dependent endocytosis of transferrin. Am J Physiol Cell Physiol. 2011;301:C1431-44 pubmed publisher
    ..Uptake of transferrin was also decreased...
  40. Marta C, Davio C, Pasquini L, Soto E, Pasquini J. Molecular mechanisms involved in the actions of apotransferrin upon the central nervous system: Role of the cytoskeleton and of second messengers. J Neurosci Res. 2002;69:488-96 pubmed
    ..Addition to cultures of an antibody against transferrin receptor (TfR), protein kinase inhibitors, or a cyclic AMP (cAMP) analogue showed that a functionally intact ..
  41. Leverence R, Mason A, Kaltashov I. Noncanonical interactions between serum transferrin and transferrin receptor evaluated with electrospray ionization mass spectrometry. Proc Natl Acad Sci U S A. 2010;107:8123-8 pubmed publisher
    The primary route of iron acquisition in vertebrates is the transferrin receptor (TfR) mediated endocytotic pathway, which provides cellular entry to the metal transporter serum transferrin (Tf)...
  42. Quarles C, Randunu K, Brumaghim J, Marcus R. Metal retention in human transferrin: consequences of solvent composition in analytical sample preparation methods. Metallomics. 2011;3:1027-34 pubmed publisher
    ..UV-VIS absorbance is employed here to monitor the iron content in human holo-transferrin (Tf) under various solvent conditions, changing polarity, pH, ionic strength, and the ionic and hydrophobic ..
  43. Park S, Kim T, Kim C, Kim S, Bang S, Park H, et al. Transferrin induces interleukin-18 expression in chronic myeloid leukemia cell line, K-562. Leuk Res. 2009;33:315-20 pubmed publisher
    b>Transferrin is an iron carrier protein involved in iron uptake and the regulation of cell growth...
  44. Dassler K, Zydek M, Wandzik K, Kaup M, Fuchs H. Release of the soluble transferrin receptor is directly regulated by binding of its ligand ferritransferrin. J Biol Chem. 2006;281:3297-304 pubmed
    The human transferrin receptor (TfR) is shed by an integral metalloprotease releasing a soluble form (sTfR) into serum...
  45. Simonsen A, Birkeland H, Gillooly D, Mizushima N, Kuma A, Yoshimori T, et al. Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci. 2004;117:4239-51 pubmed
    ..By electron microscopy, similar structures can be found within autophagosomes. We propose that Alfy might target cytosolic protein aggregates for autophagic degradation. ..
  46. Abdizadeh H, Atilgan C. Predicting long term cooperativity and specific modulators of receptor interactions in human transferrin from dynamics within a single microstate. Phys Chem Chem Phys. 2016;18:7916-26 pubmed publisher
    b>Transferrin (Tf) is an essential transport protein circulating iron in the blood and delivering it to tissues...
  47. Menke A, Fernandez Real J, Muntner P, Guallar E. The association of biomarkers of iron status with peripheral arterial disease in US adults. BMC Cardiovasc Disord. 2009;9:34 pubmed publisher
    ..The purpose of this study is to examine the association of ferritin and transferrin saturation with PAD...
  48. Fotticchia I, Guarnieri D, Fotticchia T, Falanga A, Vecchione R, Giancola C, et al. Energetics of ligand-receptor binding affinity on endothelial cells: An in vitro model. Colloids Surf B Biointerfaces. 2016;144:250-256 pubmed publisher
    ..The revealed affinity between transferrin (Tf) and transferrin receptor (TfR) in both systems is very high, Kd values are in the order of nM...
  49. Wrześniak M, Kepinska M, Królik M, Milnerowicz H. Influence of tobacco smoking on transferrin sialylation during pregnancy in smoking and non-smoking women with iron deficiency. Environ Toxicol Pharmacol. 2016;46:95-102 pubmed publisher
    Tobacco smoking influence on proteins is leading to despaired foetal nourishment. Transferrin, is an essential metal-binding protein responsible for iron transport and proper foetal development...
  50. Wang S, Kaltashov I. Identification of reduction-susceptible disulfide bonds in transferrin by differential alkylation using O(16)/O(18) labeled iodoacetic acid. J Am Soc Mass Spectrom. 2015;26:800-7 pubmed publisher
    ..Application of this method to a cysteine-rich protein transferrin allows the majority of its native disulfide bonds to be measured for their reduction susceptibility, which ..
  51. Wei W, Wu Y, Ying Y, Li S, Hu S, Zhang H. Role of augmented transferrin during the retraining for undeveloped left ventricle. J Cell Mol Med. 2015;19:2423-31 pubmed publisher
    ..b>Transferrin (TF) and ceruloplasmin were then confirmed...
  52. Lai X, Yang L, Liu X, Zhang Y, Feng J, Chen J. [Correlation analysis of tissue factor promotor polymorphism -1208I/D and venous thromboembolism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009;17:1036-9 pubmed
    ..The gene of promoter -1208I/D may not be a major susceptible gene of VTE in Chinese Han. Further investigations would be necessary to define accurately tissue factor gene polymorphisms. ..
  53. Johnson M, Enns C. Diferric transferrin regulates transferrin receptor 2 protein stability. Blood. 2004;104:4287-93 pubmed
    b>Transferrin receptor 2 (TfR2) is a type 2 transmembrane protein expressed in hepatocytes that binds iron-bound transferrin (Tf)...
  54. Kovalyov L, Shishkin S, Efimochkin A, Kovalyova M, Ershova E, Egorov T, et al. The major protein expression profile and two-dimensional protein database of human heart. Electrophoresis. 1995;16:1160-9 pubmed
    ..Each protein was characterized according to several parameters, including molecular weight, isoelectric point, name, partial sequence, subcellular localization, and genetic as well as embryonic changes. ..
  55. Wang A, Sutton H, Howard P. Human transferrins C and D-Chi: an amino acid difference. Biochem Genet. 1967;1:55-9 pubmed
  56. de Bruin E, Lemmens P, Hulshoff Pol H, Verbaten M, Kenemans J. Relationship between carbohydrate-deficient transferrin, gamma-glutamyl transferase, and mean corpuscular volume levels and alcohol-related brain volume decreases in male drinkers. Hum Psychopharmacol. 2012;27:559-65 pubmed publisher
    We investigated the association between mean corpuscular volume (MCV), carbohydrate-deficient transferrin (CDT), and gamma-glutamyl transferase (GGT) levels and gray and white brain matter in male drinkers to find out which if any of ..
  57. Steere A, Miller B, Roberts S, Byrne S, Chasteen N, Smith V, et al. Ionic residues of human serum transferrin affect binding to the transferrin receptor and iron release. Biochemistry. 2012;51:686-94 pubmed publisher
    Efficient delivery of iron is critically dependent on the binding of diferric human serum transferrin (hTF) to its specific receptor (TFR) on the surface of actively dividing cells...
  58. Baranov V, Schwartzman A, Gorbunova V, Gaitskhoki V, Rubtsov N, Timchenko N, et al. Chromosomal localization of ceruloplasmin and transferrin genes in laboratory rats, mice and in man by hybridization with specific DNA probes. Chromosoma. 1987;96:60-6 pubmed
    ..The potential and limitations of the in situ hybridization technique with heterologous DNA probes for gene mapping in mammalian species are discussed. ..
  59. Picard E, Fontaine I, Jonet L, Guillou F, Behar Cohen F, Courtois Y, et al. The protective role of transferrin in Müller glial cells after iron-induced toxicity. Mol Vis. 2008;14:928-41 pubmed
    b>Transferrin (Tf) expression is enhanced by aging and inflammation in humans. We investigated the role of transferrin in glial protection...
  60. Hu Y, Malone J, Fagan A, Townsend R, Holtzman D. Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid. Mol Cell Proteomics. 2005;4:2000-9 pubmed
    ..These results validate our method of identifying differences in proteomic profiles of CSF samples and have important implications for the design of CSF biomarker studies for AD and other central nervous system disorders. ..
  61. Strick D, Elferink L. Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment. Mol Biol Cell. 2005;16:5699-709 pubmed
    ..We previously reported that Rab15 differentially regulates transferrin receptor trafficking through sorting endosomes and the endocytic recycling compartment, suggesting a role for ..
  62. Kutalik Z, Benyamin B, Bergmann S, Mooser V, Waeber G, Montgomery G, et al. Genome-wide association study identifies two loci strongly affecting transferrin glycosylation. Hum Mol Genet. 2011;20:3710-7 pubmed publisher
    ..Variation in the carbohydrate component has been extensively studied for the iron transport protein transferrin, because serum levels of the transferrin isoforms asialotransferrin + disialotransferrin (carbohydrate-..
  63. Giannetti A, Snow P, Zak O, Bjorkman P. Mechanism for multiple ligand recognition by the human transferrin receptor. PLoS Biol. 2003;1:E51 pubmed
    b>Transferrin receptor 1 (TfR) plays a critical role in cellular iron import for most higher organisms...
  64. MacGillivray R, Moore S, Chen J, Anderson B, Baker H, Luo Y, et al. Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release. Biochemistry. 1998;37:7919-28 pubmed
    The N-lobe of human serum transferrin (hTF/2N) has been expressed in baby hamster kidney cells and crystallized in both orthorhombic (P212121) and tetragonal (P41212) space groups. Both crystal forms diffract to high resolution (1...
  65. Wang H, Huang H, Chuang Y, Liao P, Yang D, Yang W, et al. Modulation of tissue factor and thrombomodulin expression in human aortic endothelial cells incubated with high glucose. Acta Diabetol. 2012;49:125-30 pubmed publisher
    ..006). Different high glucose conditions do not provide the sufficient stress required to induce TF expression in HAECs. In contrast, high glucose conditions can induce TM expression in HAECs. ..
  66. Luciano M, Houlihan L, Harris S, Gow A, Hayward C, Starr J, et al. Association of existing and new candidate genes for anxiety, depression and personality traits in older people. Behav Genet. 2010;40:518-32 pubmed publisher
    ..No SNPs withstood the correction to significance level for multiple testing. Nevertheless, the results will be of importance to future meta-analyses of these candidate genes in relation to psychological distress and personality. ..
  67. Cap J, Lehotska V, Mayerova A. [Congenital atransferrinemia in a 11-month-old child]. Cesk Pediatr. 1968;23:1020-5 pubmed
  68. Bertram L, McQueen M, Mullin K, Blacker D, Tanzi R. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet. 2007;39:17-23 pubmed
    ..67 for protective alleles). Our database provides a powerful tool for deciphering the genetics of Alzheimer disease, and it serves as a potential model for tracking the most viable gene candidates in other genetically complex diseases. ..
  69. Martinez Pinna R, Lindholt J, Madrigal Matute J, Blanco Colio L, Esteban Salan M, Torres Fonseca M, et al. From tissue iron retention to low systemic haemoglobin levels, new pathophysiological biomarkers of human abdominal aortic aneurysm. Thromb Haemost. 2014;112:87-95 pubmed publisher
    ..Increased red blood cell (RBC)-borne iron retention and transferrin, transferrin receptor and ferritin expression was observed in AAA tissue compared to control aorta (..
  70. Mutlu A, Ozturk M, Akpinar G, Kasap M, Kanli A. Proteomics analysis of pleomorphic adenoma of the human parotid gland. Eur Arch Otorhinolaryngol. 2017;274:3183-3195 pubmed publisher
    ..hydratase, mitochondrial were down-regulated, whereas 11 proteins including ig kappa chain c region, serotransferrin, vimentin, annexin a5, glial fibrillary acidic protein, calreticulin, cartilage oligomeric matrix protein, ..
  71. Barbaro M, Passerini G, Trbos M, Soldarini A, Locatelli M. An increased CDT camouflaged a monoclonal light chain gammopathy: An approach for diagnosis. Clin Biochem. 2016;49:835-8 pubmed publisher
    Carbohydrate-deficient transferrin (CDT) is the most reliable indicator for the detection of chronic alcohol consumption...
  72. West A, Bennett M, Sellers V, Andrews N, Enns C, Bjorkman P. Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J Biol Chem. 2000;275:38135-8 pubmed
    The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis...
  73. Kim K, Jhoo J, Lee J, Lee K, Lee D, Youn J, et al. Neither the butyrylcholinesterase K variant nor transferrin C2 variant confers a risk for Alzheimer's disease in Koreans. J Neural Transm (Vienna). 2001;108:1159-66 pubmed
    To investigate the possible involvement of the butyrylcholinesterase (BCHE) K variant and transferrin (TF) C2 variant in the manifestation of Alzheimer's disease (AD), we analyzed the BCHE, TF and apolipoprotein E (APOE) genotypes of 164 ..
  74. Sergeev A, Bogadel nikova I, Agapova R, Perel man M. [Analysis of heterozygosity levels at P1,TF, PGM1, ACP1, HP, GC, GLO, C3, and ESD loci in pulmonary tuberculosis patients with different treatment outcomes]. Genetika. 2001;37:1673-80 pubmed
    ..Based on the results obtained, a genetic control was assumed for the development of the tuberculosis process in the lungs. ..
  75. Amet N, Wang W, Shen W. Human growth hormone-transferrin fusion protein for oral delivery in hypophysectomized rats. J Control Release. 2010;141:177-82 pubmed publisher
    b>Transferrin (Tf)-based recombinant fusion protein approach was investigated to achieve oral delivery for human growth hormone (hGH)...
  76. Rooijakkers S, Rasmussen S, McGillivray S, Bartnikas T, Mason A, Friedlander A, et al. Human transferrin confers serum resistance against Bacillus anthracis. J Biol Chem. 2010;285:27609-13 pubmed publisher
    ..Fractionation of serum by gel filtration chromatography led to the identification of human transferrin as the inhibiting factor. Purified transferrin blocks growth of both the fully virulent encapsulated B...