transferrin

Summary

Gene Symbol: transferrin
Description: transferrin
Alias: PRO1557, PRO2086, TFQTL1, beta-1 metal-binding globulin, serotransferrin, siderophilin
Species: human

Top Publications

  1. ncbi Structure of the human transferrin receptor-transferrin complex
    Yifan Cheng
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 116:565-76. 2004
  2. pmc How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH
    Brian E Eckenroth
    Department of Biochemistry, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 108:13089-94. 2011
  3. ncbi Structural reorganization of the transferrin C-lobe and transferrin receptor upon complex formation: the C-lobe binds to the receptor helical domain
    Rutao Liu
    Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 42:12447-54. 2003
  4. doi Molecular dynamics simulations of iron- and aluminum-loaded serum transferrin: protonation of Tyr188 is necessary to prompt metal release
    J I Mujika
    Kimika Fakultatea, Euskal Herriko Unibertsitatea UPV EHU and Donostia International Physics Center, PK 1072, 20080 Donostia, Euskadi, Spain
    Biochemistry 51:7017-27. 2012
  5. doi Carbon monoxide (CO)-releasing molecule-derived CO regulates tissue factor and plasminogen activator inhibitor type 1 in human endothelial cells
    Keiko Maruyama
    Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Thromb Res 130:e188-93. 2012
  6. doi Computational structure models of apo and diferric transferrin-transferrin receptor complexes
    Tetsuya Sakajiri
    Department of Applied Chemistry, Tokyo University of Science, Shinjuku ku, Tokyo 162 8601, Japan
    Protein J 28:407-14. 2009
  7. ncbi Ligand-induced conformational change in transferrins: crystal structure of the open form of the N-terminal half-molecule of human transferrin
    P D Jeffrey
    Department of Biochemistry, Massey University, Palmerston North, New Zealand
    Biochemistry 37:13978-86. 1998
  8. ncbi Human transferrin G277S mutation: a risk factor for iron deficiency anaemia
    P L Lee
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Br J Haematol 115:329-33. 2001
  9. ncbi The mechanism of iron release from the transferrin-receptor 1 adduct
    Miryana Hemadi
    ITODYS Interfaces, Traitements, Organisation et Dynamique des Systemes, Université Paris 7 CNRS UMR 7086, 1 rue Guy de la Brosse, 75005 Paris, France
    J Mol Biol 358:1125-36. 2006
  10. pmc Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes
    Qiang Li
    Department of Anatomy and Cell Biology, College of Medicine, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
    Mol Cell Biol 26:140-54. 2006

Research Grants

  1. IRON DELIVERY VIA BLOOD; STRUCTURAL ROLE OF TRANSFERRIN
    Anne Mason; Fiscal Year: 2005
  2. Brain Iron in Aging Adults
    George Bartzokis; Fiscal Year: 2007
  3. Iron Delivery via Blood; Structure Role of Transferrin
    Anne Mason; Fiscal Year: 2009
  4. IRON DELIVERY VIA BLOOD--STRUCTURAL ROLE OF TRANSFERRIN
    Anne Mason; Fiscal Year: 2001
  5. Iron Delivery via Blood; Structure Role of Transferrin
    Anne Mason; Fiscal Year: 2009
  6. Iron Delivery via Blood; Structure Role of Transferrin
    Anne B Mason; Fiscal Year: 2010
  7. Brain Development on Adults with Schizophrenia
    George Bartzokis; Fiscal Year: 2007
  8. Brain Iron in Aging Adults
    George Bartzokis; Fiscal Year: 2010
  9. Iron Status: A Pathway Analysis in Multiple Ethnicities
    Christine McLaren; Fiscal Year: 2009
  10. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA KAY ARMSTRONG; Fiscal Year: 2010

Detail Information

Publications101 found, 100 shown here

  1. ncbi Structure of the human transferrin receptor-transferrin complex
    Yifan Cheng
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 116:565-76. 2004
    Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR)...
  2. pmc How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH
    Brian E Eckenroth
    Department of Biochemistry, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 108:13089-94. 2011
    Delivery of iron to cells requires binding of two iron-containing human transferrin (hTF) molecules to the specific homodimeric transferrin receptor (TFR) on the cell surface...
  3. ncbi Structural reorganization of the transferrin C-lobe and transferrin receptor upon complex formation: the C-lobe binds to the receptor helical domain
    Rutao Liu
    Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 42:12447-54. 2003
    Human transferrin, a bilobal protein, with each lobe bearing a single iron-binding site, functions to transport iron into cells...
  4. doi Molecular dynamics simulations of iron- and aluminum-loaded serum transferrin: protonation of Tyr188 is necessary to prompt metal release
    J I Mujika
    Kimika Fakultatea, Euskal Herriko Unibertsitatea UPV EHU and Donostia International Physics Center, PK 1072, 20080 Donostia, Euskadi, Spain
    Biochemistry 51:7017-27. 2012
    Serum transferrin (sTf) carries iron in blood serum and delivers it into cells by receptor-mediated endocytosis. The protein can also bind other metals, including aluminum...
  5. doi Carbon monoxide (CO)-releasing molecule-derived CO regulates tissue factor and plasminogen activator inhibitor type 1 in human endothelial cells
    Keiko Maruyama
    Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Thromb Res 130:e188-93. 2012
    ..Additionally, we examined the mechanism by which CO exerts its effects...
  6. doi Computational structure models of apo and diferric transferrin-transferrin receptor complexes
    Tetsuya Sakajiri
    Department of Applied Chemistry, Tokyo University of Science, Shinjuku ku, Tokyo 162 8601, Japan
    Protein J 28:407-14. 2009
    Complexation of transferrin (Tf) and its receptor (TfR) is an essential event for iron uptake by the cell. Much data has been accumulated regarding Tf-TfR complexation, such as results from mutagenesis...
  7. ncbi Ligand-induced conformational change in transferrins: crystal structure of the open form of the N-terminal half-molecule of human transferrin
    P D Jeffrey
    Department of Biochemistry, Massey University, Palmerston North, New Zealand
    Biochemistry 37:13978-86. 1998
    Serum transferrin binds ferric ions in the bloodstream and transports them to cells, where they are released in a process involving receptor-mediated endocytosis...
  8. ncbi Human transferrin G277S mutation: a risk factor for iron deficiency anaemia
    P L Lee
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Br J Haematol 115:329-33. 2001
    Numerous polymorphisms of the transferrin gene result in a range of electrophoretic variants. We show that one of these mutations has a functional consequence...
  9. ncbi The mechanism of iron release from the transferrin-receptor 1 adduct
    Miryana Hemadi
    ITODYS Interfaces, Traitements, Organisation et Dynamique des Systemes, Université Paris 7 CNRS UMR 7086, 1 rue Guy de la Brosse, 75005 Paris, France
    J Mol Biol 358:1125-36. 2006
    ..determination in cell-free assays of the mechanism of iron release from the N-lobe and C-lobe of human serum transferrin in interaction with intact transferrin receptor 1 at 4.3< or =pH< or =6.5...
  10. pmc Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes
    Qiang Li
    Department of Anatomy and Cell Biology, College of Medicine, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
    Mol Cell Biol 26:140-54. 2006
    ..The identification of Nox-active endosomes helps explain how subcellular compartmentalization of redox signals can be used to direct receptor activation from the plasma membrane...
  11. ncbi The G277S transferrin mutation does not affect iron absorption in iron deficient women
    Beatriz Sarria
    Department of Metabolism and Nutrition, Instituto del Frio, Spanish Council for Scientific Research CSIC, C Jose Antonio Novais 10, 28040 Madrid, Spain
    Eur J Nutr 46:57-60. 2007
    ..The G277S transferrin mutation has been implicated as a risk factor for iron deficiency in menstruating women...
  12. pmc Properties of a homogeneous C-lobe prepared by introduction of a TEV cleavage site between the lobes of human transferrin
    Ashley N Steere
    Department of Biochemistry, University of Vermont, College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Protein Expr Purif 72:32-41. 2010
    Essential to iron transport and delivery, human serum transferrin (hTF) is a bilobal glycoprotein capable of reversibly binding one ferric ion in each lobe (the N- and C-lobes)...
  13. doi The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells
    Carly E Herbison
    The Univ of Western Australia, Fremantle Hospital, Australia
    Am J Physiol Cell Physiol 297:C1567-75. 2009
    b>Transferrin receptor (TFR) 1 and 2 are expressed in the liver; TFR1 levels are regulated by cellular iron levels while TFR2 levels are regulated by transferrin saturation...
  14. pmc Changes in brain gene expression shared by scrapie and Alzheimer disease
    J R Duguid
    Geriatric Research, Education and Clinical Center, Edith N Rogers Memorial Veterans Hospital, Bedford, MA 01730
    Proc Natl Acad Sci U S A 86:7260-4. 1989
    ..DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease ..
  15. ncbi Human transferrin (Tf): a single mutation at codon 570 determines Tf C1 or Tf C2 variant
    K Namekata
    Department of Neuropathology, Faculty of Medicine, University of Tokyo, Japan
    Hum Genet 100:457-8. 1997
    b>Transferrin (Tf) has many variants, as revealed by isoelectric focusing (IEF)...
  16. ncbi Alternative splicing prevents transferrin secretion during differentiation of a human oligodendrocyte cell line
    G A de Arriba Zerpa
    Unité d Expression des Gènes Eucaryotes, Institut Pasteur, Paris, France
    J Neurosci Res 61:388-95. 2000
    b>Transferrin, the iron-transport protein of vertebrate serum, is synthesized mainly in the liver, from which it is secreted into the blood...
  17. ncbi Tissue factor and coagulation factor VII levels during acute myocardial infarction: association with genotype and adverse events
    Gianluca Campo
    Department of Cardiology, University of Ferrara, 44100 Ferrara, Italy
    Arterioscler Thromb Vasc Biol 26:2800-6. 2006
    ....
  18. pmc Variants in iron metabolism genes predict higher blood lead levels in young children
    Marianne R Hopkins
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 116:1261-6. 2008
    ..Given the association between iron deficiency and lead absorption, we hypothesized that variants in iron metabolism genes would predict higher blood lead levels in young children...
  19. ncbi Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells
    Yaron Gruper
    Department of Cell Research and Immunology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    J Cell Physiol 204:901-12. 2005
    ..Based on previous and these data we suggest that the level of intracellular iron may regulate both TfR expression (on the post-transcriptional and the post-translational levels) and TfR trafficking/transcytosis in polarized cells...
  20. ncbi The position of arginine 124 controls the rate of iron release from the N-lobe of human serum transferrin. A structural study
    Ty E Adams
    Department of Biochemistry, University of Vermont, College of Medicine, Burlington, Vermont 05405, USA
    J Biol Chem 278:6027-33. 2003
    Human serum transferrin (hTF) is a bilobal iron-binding and transport protein that carries iron in the blood stream for delivery to cells by a pH-dependent mechanism...
  21. ncbi Apotransferrin promotes the differentiation of two oligodendroglial cell lines
    Pablo M Paez
    Instituto de Química y Fisicoquímica Biológica IQUIFIB, UBA CONICET, Buenos Aires, Argentina
    Glia 46:207-17. 2004
    ..The results suggest that aTf can influence OLGc gene expression and differentiation through multiple mechanisms depending on the maturation of the cell...
  22. ncbi Apotransferrin decreases migration and enhances differentiation of oligodendroglial progenitor cells in an in vitro system
    Pablo M Paez
    Instituto de Quimica y Fisicoquimica Biologica, UBA CONICET, Universidad de Buenos Aires, Argentina
    Dev Neurosci 24:47-58. 2002
    ..This effect was not observed when an antibody against the transferrin receptor was added...
  23. ncbi Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: rapid internalization and recycling upon activation
    R Forster
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    J Immunol 160:1522-31. 1998
    ..Therefore, receptor internalization and recycling may regulate the functional interaction of the receptor with envelope proteins during an initial step of HIV-1 infection...
  24. pmc Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease
    K J H Robson
    MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    J Med Genet 41:261-5. 2004
    ..There is evidence that iron may play a role in the pathology of Alzheimer's disease (AD). There may be genetic factors that contribute to iron deposition resulting in tissue damage thus exacerbating AD...
  25. doi TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia
    Peng An
    Key Laboratory of Nutrition and Metabolism, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Hum Mol Genet 21:2124-31. 2012
    ..Variants rs3811647 in TF and rs7385804 in TFR2 were associated with reduced SI, serum transferrin and transferrin saturation levels; however, these variants were not associated with iron deficiency or anemia ..
  26. pmc The immunobiology of apotransferrin in type 1 diabetes
    K Mangano
    Department of Bio Medical Sciences, Via Androne 83, 95124, Catania, Italy
    Clin Exp Immunol 169:244-52. 2012
    The transferrin (Tf) family of iron binding proteins includes important endogenous modulators of the immune function that may modulate autoimmune diseases...
  27. doi Transferrin polymorphism and opportunistic infections in HIV-infected women in Rwanda
    Florence Masaisa
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium
    Acta Haematol 128:100-6. 2012
    We investigated the prevalence of opportunistic infections in HIV-infected women according to transferrin (TF) phenotype.
  28. doi Lower tissue factor inhibition in patients with ST segment elevation than in patients with non ST elevation acute myocardial infarction
    Jaume Figueras
    Unitat Coronaria, Area del Cor, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Thromb Res 130:458-62. 2012
    ..We hypothesize, however, that STEMI patients may present lower tissue factor plasma inhibition to partly account for their more persistent coronary thrombotic occlusion...
  29. doi A unique N-glycan on human transferrin in CSF: a possible biomarker for iNPH
    Satoshi Futakawa
    Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima, Japan
    Neurobiol Aging 33:1807-15. 2012
    ..On sodium dodecyl sulfate-polyacrylamide gel electrophoresis, we found two transferrin isoforms: one had a unique N-glycan (Tf-1) whereas the other had N-glycan similar to that of serum transferrin (..
  30. pmc Structure-based mutagenesis reveals critical residues in the transferrin receptor participating in the mechanism of pH-induced release of iron from human serum transferrin
    Ashley N Steere
    Department of Biochemistry, University of Vermont, College of Medicine, Burlington, Vermont 05405, United States
    Biochemistry 51:2113-21. 2012
    The recent crystal structure of two monoferric human serum transferrin (Fe(N)hTF) molecules bound to the soluble portion of the homodimeric transferrin receptor (sTFR) has provided new details about this binding interaction that dictates ..
  31. doi Titanium preferential binding sites in human serum transferrin at physiological concentrations
    Yoana Nuevo-Ordóñez
    Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Oviedo, Spain
    Metallomics 3:1297-303. 2011
    Serum transferrin (Tf) is an iron binding glycoprotein that plays a central role in the metabolism of this essential metal but it also binds other metal ions...
  32. doi Na+/H+ exchanger isoform 6 (NHE6/SLC9A6) is involved in clathrin-dependent endocytosis of transferrin
    Lou Xinhan
    Department of Biological Sciences, Graduate School of Science, Osaka University, Machikaneyama cho 1 1, Toyonaka City, Osaka, Japan
    Am J Physiol Cell Physiol 301:C1431-44. 2011
    ..Uptake of transferrin was also decreased...
  33. pmc The protective role of transferrin in Müller glial cells after iron-induced toxicity
    Emilie Picard
    INSERM, U872, Paris, France
    Mol Vis 14:928-41. 2008
    b>Transferrin (Tf) expression is enhanced by aging and inflammation in humans. We investigated the role of transferrin in glial protection.
  34. doi Atypical serum transferrin isoform distribution in liver cirrhosis studied by HPLC, capillary electrophoresis and transferrin genotyping
    Torsten Arndt
    Bioscientia Institut fuer Medizinische Diagnostik GmbH, Ingelheim, Germany
    Clin Chim Acta 394:42-6. 2008
    ..We describe a currently unknown disialotransferrin-trisialotransferrin-bridging phenomenon (di-tri-bridge) appearing with high prevalence in serum from liver cirrhosis patients...
  35. doi Genetic variants of transferrin in cystic fibrosis
    E Marklova
    Department of Pediatrics, Charles University in Prague, University Hospital in Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic
    J Inherit Metab Dis 31:457-61. 2008
    Genetic polymorphism of serum transferrin (Tf) was studied in order to differentiate between protein genetic variants and congenital disorders of glycosylation (CDG), further focusing on unusual findings.
  36. pmc Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta
    John S K Kauwe
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Neurogenetics 10:13-7. 2009
    ....
  37. pmc Biological variability of transferrin saturation and unsaturated iron-binding capacity
    Paul C Adams
    Department of Medicine, University Hospital, London, Ontario, Canada
    Am J Med 120:999.e1-7. 2007
    b>Transferrin saturation is widely considered the preferred screening test for hemochromatosis. Unsaturated iron-binding capacity has similar performance at lower cost...
  38. ncbi Association study between the transferrin gene and schizophrenia in the Japanese population
    Nobuhisa Maeno
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neuroreport 18:517-20. 2007
    ..Of myelin and oligodendrocyte-related genes, a significant decrease in the mRNA levels of transferrin in schizophrenics has been reported by both microarray and quantitative polymerase chain reaction studies...
  39. pmc Iron genes, iron load and risk of Alzheimer's disease
    D J Lehmann
    J Med Genet 43:e52. 2006
    Compound heterozygotes of the haemochromatosis gene (HFE) variants, H63D and C282Y, have raised transferrin saturation compared with that in the wild type...
  40. pmc Assessment of Alzheimer's disease case-control associations using family-based methods
    Brit Maren M Schjeide
    MassGeneral Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neurogenetics 10:19-25. 2009
    ..Further fine-mapping and functional analyses are warranted to elucidate the potential biochemical mechanisms and epidemiological relevance of these genes...
  41. pmc Iron metabolism genes, low-level lead exposure, and QT interval
    Sung Kyun Park
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
    Environ Health Perspect 117:80-5. 2009
    ..oxidative effects of lead, we examined whether polymorphisms in iron metabolism genes [hemochromatosis (HFE), transferrin (TF) C2, and heme oxygenase-1 (HMOX-1)] increase susceptibility to the effects of lead on QT interval in 613 ..
  42. pmc Genome-wide association study identifies two loci strongly affecting transferrin glycosylation
    Zoltan Kutalik
    Department of Medical Genetics, University of Lausanne, Lausanne, 1005, Switzerland
    Hum Mol Genet 20:3710-7. 2011
    ..Variation in the carbohydrate component has been extensively studied for the iron transport protein transferrin, because serum levels of the transferrin isoforms asialotransferrin + disialotransferrin (carbohydrate-..
  43. doi In vitro interaction between ceruloplasmin and human serum transferrin
    Nguyêt Thanh Ha-Duong
    Laboratoire ITODYS Interfaces, Traitements et Organisation des Systèmes, Université Paris Diderot, CNRS UMR 7086, Bâtiment Lavoisier, 15 rue Jean Antoine de Baïf, Paris Cedex 13, France
    Biochemistry 49:10261-3. 2010
    ..These results can improve our understanding of the probable process of the transfer of iron from Cp to T in iron and copper transport and homeostasis...
  44. doi Human MRCKalpha is regulated by cellular iron levels and interferes with transferrin iron uptake
    Radek Cmejla
    Institute of Hematology and Blood Transfusion, Department of Cell Physiology, U Nemocnice 1, Prague 128 20, Czech Republic
    Biochem Biophys Res Commun 395:163-7. 2010
    ..Here we report that MRCKalpha protein expression is also regulated by iron levels; MRCKalpha colocalizes with transferrin (Tf)-loaded transferrin receptors (TfR), and attenuation of MRCKalpha expression by a short hairpin RNA ..
  45. pmc Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older men
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    J Alzheimers Dis 20:333-41. 2010
    Prevalent gene variants involved in iron metabolism [hemochromatosis (HFE) H63D and transferrin C2 (TfC2)] have been associated with higher risk and earlier age at onset of Alzheimer's disease (AD), especially in men...
  46. pmc Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease
    J S K Kauwe
    Department of Psychiatry and Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 153:955-9. 2010
    ..2004); J Med Genet 41:261-265] reported that epistatic interaction between rs1049296 (P589S) in the transferrin gene (TF) and rs1800562 (C282Y) in the hemochromatosis gene (HFE) results in significant association with risk ..
  47. pmc Excited-state lifetime studies of the three tryptophan residues in the N-lobe of human serum transferrin
    Nicholas G James
    Department of Biochemistry, University of Vermont, College of Medicine, Burlington, Vermont 05405, USA
    Protein Sci 19:99-110. 2010
    The energy transfer from the three Trp residues at positions 8, 128, and 264 within the human serum transferrin (hTF) N-lobe to the ligand to metal charge transfer band has been investigated by monitoring changes in Trp fluorescence ..
  48. doi A loop in the N-lobe of human serum transferrin is critical for binding to the transferrin receptor as revealed by mutagenesis, isothermal titration calorimetry, and epitope mapping
    Anne B Mason
    Department of Biochemistry, College of Medicine, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
    J Mol Recognit 22:521-9. 2009
    b>Transferrin (TF) is a bilobal transport protein that acquires ferric iron from the diet and holds it tightly within the cleft of each lobe (thereby preventing its hydrolysis)...
  49. pmc HFE gene variants modify the association between maternal lead burden and infant birthweight: a prospective birth cohort study in Mexico City, Mexico
    David Cantonwine
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Environ Health 9:43. 2010
    ..Polymorphisms in the hemochromatosis (HFE) iron regulatory genes have been shown to modify transport and toxicity of lead which is known to affect birth weight...
  50. doi Tissue factor gene polymorphisms and haplotypes and the risk of ischemic vascular events: four studies and a meta-analysis
    M de Gaetano
    Laboratory of Genetic and Environmental Epidemiology, RE ARTU Research Laboratories John Paul II Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    J Thromb Haemost 7:1465-71. 2009
    ..We investigated the role of genetic polymorphisms and haplotypes of the TF gene in the risk of ischemic vascular disease...
  51. doi Tissue factor and cancer
    Chloe Milsom
    Henderson Research Centre, McMaster University, Hamilton, Ont, Canada
    Pathophysiol Haemost Thromb 36:160-76. 2008
    ..The efficacy and safety of such approaches still awaits clinical verification...
  52. pmc Human growth hormone-transferrin fusion protein for oral delivery in hypophysectomized rats
    Nurmamet Amet
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California School of Pharmacy, PSC 404B, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
    J Control Release 141:177-82. 2010
    b>Transferrin (Tf)-based recombinant fusion protein approach was investigated to achieve oral delivery for human growth hormone (hGH)...
  53. ncbi Complete structure of the human transferrin gene. Comparison with analogous chicken gene and human pseudogene
    E Schaeffer
    Unite de Biochimie Cellulaire, Institut Pasteur, Paris, France
    Gene 56:109-16. 1987
    The complete structure of the human transferrin gene is presented. This gene has a total size of about 33.5 kb and is organized in 17 exons separated by 16 introns. The chicken ovotransferrin gene has a size of 10...
  54. ncbi Transferrin C2 variant does confer a risk for Alzheimer's disease in caucasians
    Pamela Zambenedetti
    Pathology Division and Brain Bank, General Hospital, Dolo Venice, Italy
    J Alzheimers Dis 5:423-7. 2003
    ..Previous studies reported higher transferrin C2 allele frequencies in Alzheimer's disease compared with normal controls...
  55. ncbi Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells
    Kyung Ran You
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Institute for Medical Science, Chonbuk National University Medical School and Hospital, Chonju, Chonbuk, South Korea
    Hepatology 38:745-55. 2003
    ..Among them, we further verified that the expression of transferrin (Tf), which is a negative acute-phase protein and is essential to cell survival as a growth factor, was highly ..
  56. pmc Proteomic and postproteomic characterization of keratan sulfate-glycanated isoforms of thyroglobulin and transferrin uniquely elaborated by papillary thyroid carcinomas
    Gaetano Magro
    Department F G Ingrassia, Section of Anatomic Pathology, University of Catania, Catania, Italy
    Am J Pathol 163:183-96. 2003
    ..approach revealed that the PTC-specific KS-bearing macromolecules were unique glycoforms of thyroglobulin and transferrin. Combined, reciprocal immunoprecipitation and Western blotting further indicated that the former glycoform ..
  57. ncbi The effects of ethanol on the glycosylation of human transferrin
    C Flahaut
    UMR 8576 du CNRS, Laboratoire de Glycobiologie Structurale et Fonctionnelle, Et Ifr 118 Ustl, 59655, Villeneuve d Ascq, France
    Glycobiology 13:191-8. 2003
    Appearance of a hyposialylated transferrin fraction in the plasma during chronic alcohol exposure is a well-known phenomenon, and it represents the best available marker of chronic alcohol consumption...
  58. ncbi Function and therapeutic development of apotransferrin
    Jaakko Parkkinen
    Finnish Red Cross Blood Transfusion Service, Helsinki, Finland
    Vox Sang 83:321-6. 2002
  59. ncbi Complexation of ytterbium to human transferrin and its uptake by K562 cells
    Xiu Lian Du
    Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, China
    Eur J Biochem 269:6082-90. 2002
    ..Lanthanide cations are similar to ferric ions with regard to transferrin binding, suggesting transferrin-receptor mediated transport is possible; however, this has not yet been ..
  60. ncbi X-ray crystallography and mass spectroscopy reveal that the N-lobe of human transferrin expressed in Pichia pastoris is folded correctly but is glycosylated on serine-32
    M C Bewley
    Institute of Molecular Biosciences, College of Sciences, Massey University, Palmerston North, New Zealand
    Biochemistry 38:2535-41. 1999
    The ferric form of the N-lobe of human serum transferrin (Fe(III)-hTF/2N) has been expressed at high levels in Pichia pastoris...
  61. ncbi Presence of alpha1-antitrypsin and transferrin in human follicular fluid--correlation with fertilization
    Vassiliki Aleporou-Marinou
    Department of Biology, University of Athens, Panepistimiopolis 15701, Athens, Greece
    Comp Biochem Physiol B Biochem Mol Biol 133:105-11. 2002
    ..of approximately 50 kDa and 80 kDa with N-terminal sequences similar to those of alpha1-antitrypsin (a1AT) and transferrin indicating that they are identical to or highly homologous to these proteins...
  62. ncbi Molecular analysis of the transferrin gene in a patient with hereditary hypotransferrinemia
    Midori Asada-Senju
    Department of Clinical Genetics, Medical Institute of Bioregulation, Kyushu University, Beppu, Oita, Japan
    J Hum Genet 47:355-9. 2002
    ..from severe anemia and growth retardation and was diagnosed on the basis of an extremely low level of serum transferrin (TF)...
  63. ncbi The human transferrin gene: 5' region contains conserved sequences which match the control elements regulated by heavy metals, glucocorticoids and acute phase reaction
    G S Adrian
    Gene 49:167-75. 1986
    b>Transferrin is a major plasma protein that transports iron to proliferating cells throughout the body. A clone containing the 5' region of the human transferrin gene has been isolated and characterized...
  64. ncbi Identification of 96 single nucleotide polymorphisms in eight genes involved in iron metabolism: efficiency of bioinformatic extraction compared with a systematic sequencing approach
    V Douabin-Gicquel
    Département de Biochimie et Biologie Moléculaire, et UMR6061 CNRS, Faculte de Medecine, 2 Avenue du Pr Léon Bernard CS34317, 35043 Rennes Cedex, France
    Hum Genet 109:393-401. 2001
    ..The average distance between the SNPs and minor allele frequencies were higher than reported by others authors; this discrepancy may reflect the nature of the genes studied and the ethnic homogeneity of our test population...
  65. ncbi Truncated brush border myosin I affects membrane traffic in polarized epithelial cells
    A Durrbach
    CNRS ERS 1984, 19 rue Guy Moquet 94801 Villejuif, France
    Traffic 1:411-24. 2000
    ..We observed that depolymerization of actin filaments using latrunculin A decreases the rate of transferrin recycling to the basolateral plasma membrane of Caco-2 cells, and increases its delivery to the apical plasma ..
  66. ncbi Molecular characterization of a case of atransferrinemia
    E Beutler
    The Scripps Research Institute, La Jolla, CA92037, USA
    Blood 96:4071-4. 2000
    ..We determined the sequences flanking the exons of the human transferrin gene and sequenced all of the exons and some of the flanking regions of the patient's DNA and that of her ..
  67. ncbi Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release
    R T MacGillivray
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada
    Biochemistry 37:7919-28. 1998
    The N-lobe of human serum transferrin (hTF/2N) has been expressed in baby hamster kidney cells and crystallized in both orthorhombic (P212121) and tetragonal (P41212) space groups. Both crystal forms diffract to high resolution (1...
  68. ncbi Exon/intron structure of the human transferrin receptor gene
    P Evans
    Department of Pathology, University of Iowa College of Medicine, Iowa City, USA
    Gene 199:123-31. 1997
    A PCR-based intron jumping strategy has been utilized to investigate the exon/intron structure of the human transferrin receptor gene and determine the sequences of exon/intron junctions...
  69. ncbi [Congenital atransferrinemia in a 11-month-old child]
    J Cap
    Cesk Pediatr 23:1020-5. 1968
  70. ncbi Human transferrins C and D-Chi: an amino acid difference
    A C Wang
    Biochem Genet 1:55-9. 1967
  71. ncbi Molecular characterization of a third case of human atransferrinemia
    A S Knisely
    Blood 104:2607. 2004
  72. ncbi Polymorphisms of Transferrin gene are associated with schizophrenia in Chinese Han population
    Mei Qu
    Key laboratory for Mental Health, Ministry of Health, Institute of Mental Health, Peking University, 51 Hua Yuan Bei Road, Beijing 100083, China
    J Psychiatr Res 42:877-83. 2008
    ..b>Transferrin (TF), an iron transport glycoprotein playing an important role in synthesis of myelin and the development of ..
  73. ncbi Serum level of sialic acid (SA) and carbohydrate-deficient transferrin (CDT) in type 2 diabetes mellitus with microvascular complications
    Bogdan Cylwik
    Department of Biochemical Diagnostics, Medical University, Bialystok, Poland
    J Clin Lab Anal 20:68-73. 2006
    Sialic acid (SA) is responsible for the composition of different isoforms of transferrin and is reported to be a marker of microvascular complications in type 2 diabetes mellitus...
  74. doi The impact of highly hydrophobic material on the structure of transferrin and its ability to bind iron
    E Drug
    School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Toxicol Lett 203:33-9. 2011
    b>Transferrin is a blood-plasma glycoprotein, which is responsible for ferric-ion delivery and which functions as the most important ferric pool in the body...
  75. ncbi Aluminum exposure affects transferrin-dependent and -independent iron uptake by K562 cells
    Gladys Pérez
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon II, Piso 4, Ciudad Universitaria, Ciudad de Buenos Aires C1428EHA, Argentina
    Biochim Biophys Acta 1745:124-30. 2005
    Aluminum (Al) and iron (Fe) share several physicochemical characteristics and they both bind to transferrin (Tf), entering the cell via Tf receptors (TfR)...
  76. ncbi Soluble transferrin receptor and mutations in hemochromatosis and transferrin genes in a general Catalan population
    Victória Bérez
    Centre de Recerca Biomedica, Hospital Universitari de Sant Joan, Institut de Recerca en Ciències de la Salut, C Sant Joan s n, 43201 Reus, Catalunya, Spain
    Clin Chim Acta 353:205-8. 2005
    The measurement of soluble transferrin receptor (sTfR) has been proposed as a valuable marker of erythropoietic activity and iron status...
  77. ncbi Association study of the G258S transferrin gene polymorphism and Parkinson's disease in the Spanish population
    Mario Ezquerra
    J Neurol 252:1269-70. 2005
  78. ncbi The C2 variant of human serum transferrin retains the iron binding properties of the native protein
    Paolo Zatta
    CNR Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padova, Vle G Colombo, 3, 3512 Padova, Italy
    Biochim Biophys Acta 1741:264-70. 2005
    The tryptic digests of blood samples obtained from transferrin C1 and C2 (TfC 1 and TfC2 hereafter) genotypes were analysed by Liquid Chromatography coupled to Electrospray Mass Spectrometry (LC/ESI--MS/MS)...
  79. ncbi Neither human hephaestin nor ceruloplasmin forms a stable complex with transferrin
    David M Hudson
    Centre for Blood Research and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    J Cell Biochem 103:1849-55. 2008
    ..In the intracellular milieu, it is likely that iron exists as reduced Fe(II), yet transferrin (Tf), the plasma iron transporter, is only capable of binding oxidized Fe(III)...
  80. ncbi Febrile-range temperature but not heat shock augments the acute phase response to interleukin-6 in human hepatoma cells
    Stephen J Wigmore
    Liver Research Group, University of Birmingham, Institute of Biomedical Research 5th Floor, Wolfson Drive, Birmingham B15 2TT, UK
    Am J Physiol Gastrointest Liver Physiol 290:G903-11. 2006
    ..of cells with IL-6 also prevented heat shock-induced suppression of alpha(1)-antichymotrypsin (ACT) but not transferrin. mRNA expression of ACT and alpha(1)-antitrypsin reporter activation studies was consistent with ..
  81. ncbi The major protein expression profile and two-dimensional protein database of human heart
    L I Kovalyov
    Research Center of Medical Genetics, Russian Academy of Medical Sciences, Moscow
    Electrophoresis 16:1160-9. 1995
    ..Each protein was characterized according to several parameters, including molecular weight, isoelectric point, name, partial sequence, subcellular localization, and genetic as well as embryonic changes...
  82. pmc The complete amino acid sequence of human serum transferrin
    R T MacGillivray
    Proc Natl Acad Sci U S A 79:2504-8. 1982
    The complete amino acid sequence of human serum transferrin has been determined by aligning the structures of the 10 CNBr fragments...
  83. ncbi Genes related to iron metabolism and susceptibility to Alzheimer's disease in Basque population
    L Blazquez
    Experimental Unit, Donostia Hospital, San Sebastian, Spain
    Neurobiol Aging 28:1941-3. 2007
    ..9%) than in AD patients (18%), suggesting a protective role of this allele on AD either due to the presence of the mutation itself or through the effect of other related genes in the ancestral haplotype in which it is included...
  84. ncbi ACAP1 promotes endocytic recycling by recognizing recycling sorting signals
    Jun Dai
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 7:771-6. 2004
    ..Taken together, these findings indicate that ACAP1 promotes cargo sorting by recognizing recycling sorting signals...
  85. pmc The unique kinetics of iron release from transferrin: the role of receptor, lobe-lobe interactions, and salt at endosomal pH
    Shaina L Byrne
    Department of Biochemistry, College of Medicine, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
    J Mol Biol 396:130-40. 2010
    ..Human serum transferrin (hTF) carries one iron in each of two similar lobes...
  86. doi Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia
    Daniel Martins-de-Souza
    Laboratorio de Neurociencias, Instituto de Psiquiatria, Faculdade de Medicina da USP, Rua Dr Ovidio Pires de Campos, SP, Brazil
    J Psychiatr Res 43:978-86. 2009
    ..previously implicated in schizophrenia, such as oligodendrocyte-related proteins (myelin basic protein and transferrin), as well as malate dehydrogenase, aconitase, ATP synthase subunits and cytoskeleton-related proteins...
  87. pmc siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake
    Thierry Galvez
    Department of Chemical and Systems Biology and Bio X Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    Genome Biol 8:R142. 2007
    Iron uptake via endocytosis of iron-transferrin-transferrin receptor complexes is a rate-limiting step for cell growth, viability and proliferation in tumor cells as well as non-transformed cells such as activated lymphocytes...
  88. ncbi Overexpression of human transferrin in two oligodendroglial cell lines enhances their differentiation
    Pablo M Paez
    Instituto de Química y Fisicoquímica Biológica IQUIFIB, UBA CONICET, and Departamento de Química Biológica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina
    Glia 52:1-15. 2005
    ..This co-culture system represents a potentially powerful tool to study neuron-glia interactions that occur during myelinogenesis and the role of Tf in this process...
  89. ncbi Diferric transferrin regulates transferrin receptor 2 protein stability
    Martha B Johnson
    Department of Biochemistry, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Blood 104:4287-93. 2004
    b>Transferrin receptor 2 (TfR2) is a type 2 transmembrane protein expressed in hepatocytes that binds iron-bound transferrin (Tf)...
  90. ncbi 5- and 6-glycosylation of transferrin in patients with Alzheimer's disease
    Susan J van Rensburg
    Department of Chemical Pathology, National Health Laboratory Service, Tygerberg Hospital and Stellenbosch University, South Africa
    Metab Brain Dis 19:89-96. 2004
    b>Transferrin is a glycosylated metal-carrying serum protein. One of the biological functions of glycosylation is to regulate the life span of proteins, less glycosylation leading to a faster clearance of a protein from the circulation...
  91. ncbi The first epidermal growth factor-like domains of factor Xa and factor IXa are important for the activation of the factor VII--tissue factor complex
    M Ndonwi
    Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, Saint Louis, MO, USA
    J Thromb Haemost 3:112-8. 2005
    ..We conclude that the EGF1 domains of FXa and FIXa are important for the activation of FVII-TF and for the formation of FVIIa-TF-FXa-TFPI complex...
  92. ncbi Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Genet 39:17-23. 2007
    ..67 for protective alleles). Our database provides a powerful tool for deciphering the genetics of Alzheimer disease, and it serves as a potential model for tracking the most viable gene candidates in other genetically complex diseases...
  93. ncbi Differential effect of a his tag at the N- and C-termini: functional studies with recombinant human serum transferrin
    Anne B Mason
    Department of Biochemistry, University of Vermont, College of Medicine, Burlington, Vermont 05405, USA
    Biochemistry 41:9448-54. 2002
    ..Thus, the presence of a His tag at either the N- or C-terminus of hTF-NG has no apparent effect on the ability of these hTF species to bind to transferrin receptors.
  94. ncbi Cell-mediated LDL oxidation: the impact of transition metals and transferrin
    Ann Van Campenhout
    Laboratory of Endocrinology, University of Antwerp, Belgium
    Biochem Biophys Res Commun 338:1617-24. 2005
    ..in vitro oxidation of low-density lipoproteins (LDL), as well as the impact of the metal-binding protein transferrin (Tf). LDL oxidation was measured by monitoring the increase in fluorescence (350/440 nm excitation/emission)...
  95. ncbi Transferrin is an insulin-like growth factor-binding protein-3 binding protein
    S A Weinzimer
    Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 86:1806-13. 2001
    ..We have here characterized transferrin (Tf) as one of these IGFBP-3 binding proteins...
  96. ncbi Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid
    Yan Hu
    Department of Neurology, Division of Metabolism and Proteomics Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Proteomics 4:2000-9. 2005
    ..These results validate our method of identifying differences in proteomic profiles of CSF samples and have important implications for the design of CSF biomarker studies for AD and other central nervous system disorders...
  97. ncbi Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites
    A P West
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    J Mol Biol 313:385-97. 2001
    The transferrin receptor (TfR) binds two proteins critical for iron metabolism: transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis...
  98. pmc ProApolipoprotein A1: a serum marker of brain metastases in lung cancer patients
    Nicola Marchi
    Cerebrovascular Research, Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    Cancer 112:1313-24. 2008
    ..However, a confounding factor was the presence of BBB changes due to cerebrovascular disease...
  99. pmc Alveolar type I cells protect rat lung epithelium from oxidative injury
    Jiwang Chen
    Department of Physiological Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    J Physiol 572:625-38. 2006
    ..Two genes, apolipoprotein E (Apo E) and transferrin, were further characterized and functionally studied...

Research Grants68

  1. IRON DELIVERY VIA BLOOD; STRUCTURAL ROLE OF TRANSFERRIN
    Anne Mason; Fiscal Year: 2005
    Iron sequestration in blood plasma by transferrin and delivery of this iron via receptor mediated endocytosis to various tissues, such as bone marrow and liver, are biologically essential functions...
  2. Brain Iron in Aging Adults
    George Bartzokis; Fiscal Year: 2007
    ....
  3. Iron Delivery via Blood; Structure Role of Transferrin
    Anne Mason; Fiscal Year: 2009
    Members of the transferrin family (serum transferrin, ovotransferrin & lactoferrin) bind iron with different affinities in each of two lobes, although all lobes have identical amino acid ligands to the iron...
  4. IRON DELIVERY VIA BLOOD--STRUCTURAL ROLE OF TRANSFERRIN
    Anne Mason; Fiscal Year: 2001
    ..g., human transferrin, hen ovo-transferrin and half-molecules thereof, based on a series of site directed mutants...
  5. Iron Delivery via Blood; Structure Role of Transferrin
    Anne Mason; Fiscal Year: 2009
    Members of the transferrin family (serum transferrin, ovotransferrin & lactoferrin) bind iron with different affinities in each of two lobes, although all lobes have identical amino acid ligands to the iron...
  6. Iron Delivery via Blood; Structure Role of Transferrin
    Anne B Mason; Fiscal Year: 2010
    Members of the transferrin family (serum transferrin, ovotransferrin &lactoferrin) bind iron with different affinities in each of two lobes, although all lobes have identical amino acid ligands to the iron...
  7. Brain Development on Adults with Schizophrenia
    George Bartzokis; Fiscal Year: 2007
    ..This will change our concept of how we could treat this illness, the feasibility of changing its lifelong course, and would encourage the development of novel pharmacologic interventions to improve myelination. ..
  8. Brain Iron in Aging Adults
    George Bartzokis; Fiscal Year: 2010
    ....
  9. Iron Status: A Pathway Analysis in Multiple Ethnicities
    Christine McLaren; Fiscal Year: 2009
    ..Potential study results could be used to identify individuals at risk for iron deficiency and to develop innovative prevention and treatment strategies. ..
  10. IRON ACQUISITION IN BORDETELLA PERTUSSIS
    SANDRA KAY ARMSTRONG; Fiscal Year: 2010
    ..investigate the means by which Bordetella cells use host neuroendocrine stress hormones to obtain the iron from transferrin and lactoferrin...
  11. Iron Status: A Pathway Analysis in Multiple Ethnicities
    Christine McLaren; Fiscal Year: 2007
    ..Potential study results could be used to identify individuals at risk for iron deficiency and to develop innovative prevention and treatment strategies. ..
  12. A Mouse Model of Gaucher Disease
    Ernest Beutler; Fiscal Year: 2005
    ..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
  13. Oxidative modification of brain proteins in pesticide intoxication
    PIER MASTROBERARDINO; Fiscal Year: 2007
    ..The goal of this proposal is to find biomarkers to monitor the progression of intoxication before symptoms appear, in order to develop therapies that can be administrated at earlier stages. ..
  14. Anemia in the Elderly: Pathogenesis
    Ernest Beutler; Fiscal Year: 2007
    ..If such differences also occur among controls they could account for the broad normal variation in hemoglobin levels. ..
  15. SEARCH FOR NOVEL EARLY-ONSET ALZHEIMER'S GENES
    Lars Bertram; Fiscal Year: 2007
    ..While we have devised a strategy that integrates the best available methods to identify complex disease genes, we will routinely adjust our strategy to account for methodologic advances in this rapidly evolving field. ..
  16. INVESTIGATIVE HEMATOLOGY
    Ernest Beutler; Fiscal Year: 2007
    ..The training faculty for this program work in approximately 30,000 square feet of laboratory space used exclusively for biomedical research ..
  17. IRON TRANSPORT IN MAMMALIAN CELLS
    Philip Aisen; Fiscal Year: 2003
    ..are: Project 1: Mechanisms of cellular iron uptake from transferring focuses on cellular iron acquisition from transferrin by receptor-independent routes, and also includes studies of transferrin-transferrin receptor interactions (in ..
  18. Hemochromatosis -- Epidemiology and Molecular Mechanisms
    Ernest Beutler; Fiscal Year: 2003
    ..attended the Kaiser Permanente Health Appraisal Clinic and extensive health data including serum ferritin and transferrin saturation and HFE genotype have been obtained on virtually all of these subjects...
  19. HEMOCHROMATOSIS--EPIDEMIOLOGY AND MOLECULAR MECHANISMS
    Ernest Beutler; Fiscal Year: 2002
    ..This will be done by using immunoprecipitating HLA-H containing complexes, determining HLA-H Fc receptor signaling properties and measuring the binding of peptides and other small molecules by HLA-H. ..
  20. FORMATION AND SURVIVAL OF RED BLOOD CELLS
    Ernest Beutler; Fiscal Year: 2001
    ..Should these point mutations fail to alter gene transcription, a search will be made for other potential mutations in linkage disequilibrium with the known -5,-8 and -24 polymorphisms, by sequencing upstream through the promotor. ..
  21. IRON BINDING PROTEINS AND CONTROL OF IRON METABOLISM
    Philip Aisen; Fiscal Year: 2001
    ..Human transferrin, the major interest of this research, serves in the circulatory transport of iron for cellular needs...
  22. IRON BINDING PROTEINS AND CONTROL OF IRON METABOLISM
    Philip Aisen; Fiscal Year: 1993
    ..Kinetic, spectroscopic and physiologic methods will be applied to the study of serum transferrin, in efforts to understand the detailed features of iron uptake from the protein by cells...
  23. Hemochromatosis -- Epidemiology and Molecular Mechanisms
    Ernest Beutler; Fiscal Year: 2006
    ..attended the Kaiser Permanente Health Appraisal Clinic and extensive health data including serum ferritin and transferrin saturation and HFE genotype have been obtained on virtually all of these subjects...