transcobalamin II

Summary

Gene Symbol: transcobalamin II
Description: transcobalamin 2
Alias: D22S676, D22S750, TC II, TC-2, TC2, TCII, transcobalamin-2, macrocytic anemia, transcobalamin II, transcobalamin II; macrocytic anemia, vitamin B12-binding protein 2
Species: human
Products:     transcobalamin II

Top Publications

  1. Namour F, Olivier J, Abdelmouttaleb I, Adjalla C, Debard R, Salvat C, et al. Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in blood. Blood. 2001;97:1092-8 pubmed
    ..02 and P =.01, respectively). In conclusion, TC codon-259 polymorphism affects TC plasma concentration and may interfere in vitamin B(12) cellular availability and homocysteine metabolism. ..
  2. Afman L, Lievers K, van der Put N, Trijbels F, Blom H. Single nucleotide polymorphisms in the transcobalamin gene: relationship with transcobalamin concentrations and risk for neural tube defects. Eur J Hum Genet. 2002;10:433-8 pubmed
  3. Zetterberg H, Regland B, Palmer M, Rymo L, Zafiropoulos A, Arvanitis D, et al. The transcobalamin codon 259 polymorphism influences the risk of human spontaneous abortion. Hum Reprod. 2002;17:3033-6 pubmed
    ..Our results warrant additional investigations addressing the question if vitamin B(12) supplementation in addition to folic acid supplementation may prevent spontaneous abortion in women planning a pregnancy. ..
  4. Bowen R, Wong B, Cole D. Population-based differences in frequency of the transcobalamin II Pro259Arg polymorphism. Clin Biochem. 2004;37:128-33 pubmed
    A common polymorphism of the transcobalamin II (TC-II) gene, Pro250Arg, has been implicated as a possible genetic factor in population-based differences in vitamin B(12) metabolism...
  5. Martinelli M, Scapoli L, Palmieri A, Pezzetti F, Baciliero U, Padula E, et al. Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate. Hum Mutat. 2006;27:294 pubmed
    ..However, because conflicting data exist with regard to the effect of the polymorphism in transcobalamin 2 function or in perturbing plasma levels of key molecules in the folate pathway, further investigation is ..
  6. Aléssio A, Hoehr N, Siqueira L, Bydlowski S, Annichino Bizzacchi J. Polymorphism C776G in the transcobalamin II gene and homocysteine, folate and vitamin B12 concentrations. Association with MTHFR C677T and A1298C and MTRR A66G polymorphisms in healthy children. Thromb Res. 2007;119:571-7 pubmed
    One of the etiologies of hyperhomocysteinemia is decreased vitamin B(12). Genetic variation in the transcobalamin II gene, the transporter of vitamin B(12) to the cells, may produce altered homocysteine levels...
  7. James S, Melnyk S, Jernigan S, Cleves M, Halsted C, Wong D, et al. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:947-56 pubmed
    ..gene-gene interactions were found for relevant genes encoding the reduced folate carrier (RFC 80G > A), transcobalamin II (TCN2 776G > C), catechol-O-methyltransferase (COMT 472G > A), methylenetetrahydrofolate reductase (..
  8. Gueant J, Chabi N, Guéant Rodriguez R, Mutchinick O, Debard R, Payet C, et al. Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2). J Med Genet. 2007;44:363-7 pubmed
    ..Given the dramatic heterogeneity of the 776G allele frequency worldwide, this polymorphism may be prone to a selective pressure or confers an evolutionary advantage in confronting environmental factors, one of which is malaria. ..
  9. Böttiger A, Nilsson T. Pyrosequencing assay for genotyping of the Transcobalamin II 776C>G polymorphism. Scand J Clin Lab Invest. 2007;67:247-51 pubmed
    The 776C>G polymorphism of the Transcobalamin II gene is located in a GC-rich region and TaqMan real-time polymerase chain reaction (PCR) does not yield satisfactory genotyping results...

More Information

Publications178 found, 100 shown here

  1. Fredriksen A, Meyer K, Ueland P, Vollset S, Grotmol T, Schneede J. Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism. Hum Mutat. 2007;28:856-65 pubmed
    ..2756A>G (tHcy), BHMT c.716G>A (DMG), CBS c.844_845ins68 (tHcy, betaine), CBS c.699C>T (tHcy, betaine, cystathionine) and TCN2 c.776C>G (MMA). No associations were observed for the other polymorphisms investigated. ..
  2. Verkleij Hagoort A, van Driel L, Lindemans J, Isaacs A, Steegers E, Helbing W, et al. Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: a Dutch case-control study. Mol Genet Metab. 2008;94:112-9 pubmed publisher
    ..We investigated methionine synthase reductase (MTRR) and transcobalamin II (TC) genes and maternal intake and serum concentrations of vitamin B12 in association with CHD risk...
  3. Stanisławska Sachadyn A, Woodside J, Sayers C, Yarnell J, Young I, Evans A, et al. The transcobalamin (TCN2) 776C>G polymorphism affects homocysteine concentrations among subjects with low vitamin B(12) status. Eur J Clin Nutr. 2010;64:1338-43 pubmed publisher
    ..Thus, the TCN2 776C>G polymorphism may contribute to the risk of pathologies associated with a low B(12), and high tHcy phenotype. ..
  4. Miller J, Ramos M, Garrod M, Flynn M, Green R. Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adults. Blood. 2002;100:718-20 pubmed
    A common polymorphism (775G>C) in the vitamin B12 transport protein, transcobalamin II (TCII), has been identified in which proline replaces arginine at codon 259...
  5. Swanson D, Pangilinan F, Mills J, Kirke P, Conley M, Weiler A, et al. Evaluation of transcobalamin II polymorphisms as neural tube defect risk factors in an Irish population. Birth Defects Res A Clin Mol Teratol. 2005;73:239-44 pubmed
    ..Low levels of maternal plasma vitamin B(12) and reduced binding of vitamin B(12) by transcobalamin II (TCII) are independent risk factors for NTDs...
  6. Wuerges J, Garau G, Geremia S, Fedosov S, Petersen T, Randaccio L. Structural basis for mammalian vitamin B12 transport by transcobalamin. Proc Natl Acad Sci U S A. 2006;103:4386-91 pubmed
    ..Structural information is used to predict the overall fold of haptocorrin and intrinsic factor and permits a rational approach to the design of new Cbl-based bioconjugates for diagnostic or therapeutic drug delivery. ..
  7. Brouns R, Ursem N, Lindemans J, Hop W, Pluijm S, Steegers E, et al. Polymorphisms in genes related to folate and cobalamin metabolism and the associations with complex birth defects. Prenat Diagn. 2008;28:485-93 pubmed publisher
    ..0 (1.1-15.4). Other genotypes did not show significant associations. The MTHFR 677C > T polymorphism in conjunction with reduced folate- and/or cobalamin status may increase the risk of complex birth defects. ..
  8. Linnebank M, Moskau S, Jürgens A, Simon M, Semmler A, Orlopp K, et al. Association of genetic variants of methionine metabolism with methotrexate-induced CNS white matter changes in patients with primary CNS lymphoma. Neuro Oncol. 2009;11:2-8 pubmed publisher
    ..1298A>C (chi(2) = 13.5; p = 0.001; df = 2), and the GG genotype of transcobalamin 2 c.776C>G (chi(2) = 19.73; p < 0.001), in addition to male gender (chi(2) = 11.95; p = 0.001)...
  9. Sysel A, Valli V, Bauer J. Immunohistochemical quantification of the cobalamin transport protein, cell surface receptor and Ki-67 in naturally occurring canine and feline malignant tumors and in adjacent normal tissues. Oncotarget. 2015;6:2331-48 pubmed
    ..This study quantified the immunohistochemical expression of the cobalamin transport protein (transcobalamin II; TCII), cell surface receptor (transcobalamin II-R; TCII-R) and proliferation protein (Ki-67) in naturally ..
  10. Chen X, Chen S, Li C, Zhu Y, Peng B. Skewed T-cell subsets and enhanced macrophages phagocytosis in the spleen of patients with immune thrombocytopenia failing glucocorticoids. Int J Hematol. 2011;94:248-254 pubmed publisher
    ..ITP patients had similar percentages of Th1, Tc1, and T1 (Th1 + Tc1) cells, but lower percentages of Th2 and Tc2 cells, which did not, however, reach significant difference...
  11. Hilvering B, Hinks T, Stöger L, Marchi E, Salimi M, Shrimanker R, et al. Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma. Mucosal Immunol. 2018;11:1408-1419 pubmed publisher
    ..cohorts we show that, in contrast to Th2 cells, type-2 cytokine-secreting CD8+CRTH2+ (Tc2) cells are enriched in blood and airways in severe eosinophilic asthma...
  12. Hazra A, Fuchs C, Kawasaki T, Kirkner G, Hunter D, Ogino S. Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer. Cancer Causes Control. 2010;21:331-45 pubmed publisher
    ..Collectively, these exploratory data provide suggestive evidence for the association of MTHFR 429 Ala/ Ala and TCN2 259 Arg/Arg and CIMP status in colorectal cancer. ..
  13. Mitchell E, Conus N, Kaput J. B vitamin polymorphisms and behavior: evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline. Neurosci Biobehav Rev. 2014;47:307-20 pubmed publisher
    ..and function, such as methylene tetrahydrofolate reductase (MTHFR), cystathionine β synthase (CβS), transcobalamin 2 receptor (TCN2) and methionine synthase reductase (MTRR), have also been linked to increased incidence of ..
  14. Schedel M, Jia Y, Michel S, Takeda K, Domenico J, Joetham A, et al. 1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter. Nat Commun. 2016;7:10213 pubmed publisher
    Effector CD8(+) T cells convert from IFN-γ(+) (Tc1) to IL-13(+) (Tc2) cells in the presence of IL-4. Underlying regulatory mechanisms are not fully defined...
  15. Song Y, Wang Y, Huang X, Kong Y. Abnormalities of the bone marrow immune microenvironment in patients with immune thrombocytopenia. Ann Hematol. 2016;95:959-65 pubmed publisher
    ..Subsets of T cells in the BM immune microenvironment, including Th1, Th2, Tc1, Tc2, Th17, and Treg cells, were analyzed via flow cytometry...
  16. Czarnowicki T, He H, Wen H, Hashim P, Nia J, Malik K, et al. Alopecia areata is characterized by expansion of circulating Th2/Tc2/Th22, within the skin-homing and systemic T-cell populations. Allergy. 2017;: pubmed publisher
    ..We aimed to compare frequencies of skin homing (CLA+ ) vs. systemic (CLA- ) "polar" CD4+ and CD8+ and activated T-cell subsets in AA vs. AD and control blood...
  17. Pangilinan F, Mitchell A, Vandermeer J, Molloy A, Troendle J, Conley M, et al. Transcobalamin II receptor polymorphisms are associated with increased risk for neural tube defects. J Med Genet. 2010;47:677-85 pubmed publisher
    ..The transcobalamin II receptor (TCblR) mediates uptake of cobalamin into cells...
  18. Lopes Marques M, Ruivo R, Delgado I, Wilson J, Aluru N, Castro L. Basal Gnathostomes provide unique insights into the evolution of vitamin B12 binders. Genome Biol Evol. 2014;7:457-64 pubmed publisher
    ..in mammals involves a refined system with three evolutionarily related transporters: transcobalamin 1 (Tcn1), transcobalamin 2 (Tcn2), and the gastric intrinsic factor (Gif)...
  19. Gehad A, Teague J, Matos T, Huang V, Yang C, Watanabe R, et al. A primary role for human central memory cells in tissue immunosurveillance. Blood Adv. 2018;2:292-298 pubmed publisher
    ..TCM also had potent effector functions; 80% of CD8+ TCM produced TC1/TC2/TC17/TC22 cytokines...
  20. Liu W, Li H, Hao Y, Li Y, Lv M, Xue F, et al. Decreased immunosuppressive actions of 1?, 25-dihydroxyvitamin D3 in patients with immune thrombocytopenia. Mol Immunol. 2016;78:89-97 pubmed publisher
    ..inhibited the differentiation of T helper (Th)1 and Tc1 cells but induced the differentiation of Th2, Tc2 and T regulatory (Treg) cells in ITP patients...
  21. Zerif E, Maalem A, Gaudreau S, Guindi C, Ramzan M, Véroneau S, et al. Constitutively active Stat5b signaling confers tolerogenic functions to dendritic cells of NOD mice and halts diabetes progression. J Autoimmun. 2017;76:63-74 pubmed publisher
    ..Protection was associated with an increased in the pool and suppressive function of Tregs, a promotion of Th2 and Tc2 immune response and a decreased percentage of CD8+ T cells. Splenic DCs of NOD...
  22. Ni H, Xiao Y. [Expression and meaning of T-bet and GATA3 mRNA in T lymphocyte of patients during the operation with cardiopulmonary bypass]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:1107-1111 pubmed publisher
    ..05). CPB causes the imbalance of Th1, Tc1/Th2, Tc2 and pro-inflammatory and anti-inflammatory reactions specially, which participate the complication occurrence after ..
  23. Zou M, Sun C, Liang S, Sun Y, Li D, Li L, et al. Fisher discriminant analysis for classification of autism spectrum disorders based on folate-related metabolism markers. J Nutr Biochem. 2019;64:25-31 pubmed publisher
    ..methonine, the ratio of S-adenosylmethionine/S-adenosylhomocysteine, methionine synthase and transcobalamin II. The model had statistical significance (lambda=0.520, χ2=113.103, df=6, P<...
  24. Kurzwelly D, Knop S, Guenther M, Loeffler J, Korfel A, Thiel E, et al. Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient population. J Neurooncol. 2010;100:187-92 pubmed publisher
    ..57; 1.05-2.34). There were no associations of the other polymorphisms investigated (MTHFR c.677C > T, transcobalamin 2 (Tc2) c.776C > G, cystathionin beta-synthase (CBS) c.844_855ins68, reduced folate carrier-1 (RFC-1) c...
  25. Semmler A, Farmand S, Moskau S, Stoffel Wagner B, Linnebank M. The G allele of transcobalamin 2 c.776C?G is associated with an unfavorable lipoprotein profile. Ann Nutr Metab. 2010;57:112-5 pubmed publisher
    ..2756A?G, methylenetetrahydrofolate reductase c.677C?T and c.1298A?C, reduced folate carrier 1 c.80G?A, and transcobalamin 2 (Tc2) c.776C?G. Linear regression analysis showed an association of Tc2 c.776C?G with LDL (p = 0...
  26. Wen Q, Kong Y, Zhao H, Zhang Y, Han T, Wang Y, et al. G-CSF-induced macrophage polarization and mobilization may prevent acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2019;: pubmed publisher
    ..Moreover, post-BM MΦs reduced the percentage of Th1 and Tc1 lineages and increased the percentage of Th2, Tc2, and Treg lineages...
  27. Song Y, Shi M, Zhang Y, Mo X, Wang Y, Zhang X, et al. Abnormalities of the Bone Marrow Immune Microenvironment in Patients with Prolonged Isolated Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2017;23:906-912 pubmed publisher
    ..Th1, Th2, Tc1, Tc2, Th17, and Treg cells were analyzed by flow cytometry, and IFN-γ, IL-4, IL-17, IL-6, IL-21, and thrombopoietin ..
  28. Delasoie J, Rossier J, Haeni L, Rothen Rutishauser B, Zobi F. Slow-targeted release of a ruthenium anticancer agent from vitamin B12 functionalized marine diatom microalgae. Dalton Trans. 2018;47:17221-17232 pubmed publisher
    ..diatoms was at least 3 times higher than that of the unmodified ones and was correlated with the increased transcobalamin II (TC(II)) and transcobalamin II receptor (TC(II)-R) expression of the targeted tissue...
  29. Liang Y, Zhang X, Bai X, Yang Y, Gong W, Wang T, et al. Immunogenicity and therapeutic effects of latency-associated genes in a Mycobacterium tuberculosis reactivation mouse model. Hum Gene Ther Methods. 2019;: pubmed publisher
    ..05). Compared with the saline group, Tc1 cells in the rv2029c DNA group and Tc1/Tc2 cell ratio in the rv1813c DNA, rv2628 DNA and rv2029c DNA groups were significantly decreased (P<0.05)...
  30. Eussen S, Vollset S, Hustad S, Midttun Ø, Meyer K, Fredriksen A, et al. Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev. 2010;19:28-38 pubmed publisher
    ..In summary, results from this large European cohort study showed an inverse association between vitamin B2 and GC risk, which is borderline significant, and a significant inverse association between vitamin B6 and GC risk. ..
  31. Jiang C, Yin N, Zhao Z, Wu D, Wang Y, Li H, et al. Lack of Association Between MTHFR, MTR, MTRR, and TCN2 Genes and Nonsyndromic CL±P in a Chinese Population: Case-Control Study and Meta-Analysis. Cleft Palate Craniofac J. 2015;52:579-87 pubmed publisher
    ..The alterations of folate metabolism related to these polymorphisms are not involved in NSCLP in the Chinese population. ..
  32. Lin G, Tepp W, Bradshaw M, Fredrick C, Johnson E. Immunoprecipitation of native botulinum neurotoxin complexes from Clostridium botulinum subtype A strains. Appl Environ Microbiol. 2015;81:481-91 pubmed publisher
    ..TCs) are (i) TC1, consisting of BoNT, nontoxin-nonhemagglutinin (NTNH), and hemagglutinins (HAs), and (ii) TC2, consisting of BoNT and NTNH (and possibly OrfX proteins)...
  33. Nongmaithem S, Joglekar C, Krishnaveni G, Sahariah S, Ahmad M, Ramachandran S, et al. GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians. Hum Mol Genet. 2017;26:2551-2564 pubmed publisher
    ..Our results suggest that in addition to established genetic variants, population-specific variants are important in determining plasma B12 concentrations. ..
  34. Rodan L, Mishra N, Yau I, Andrade A, Siriwardena K, Tein I. Expanding the Spectrum of Methylmalonic Acid-Induced Pallidal Stroke: First Reported Case of Metabolic Globus Pallidus Stroke in Transcobalamin II Deficiency. JIMD Rep. 2013;11:7-11 pubmed publisher
    A 10-year-old boy with transcobalamin II (TCII) deficiency on oral cyanocobalamin therapy presented with acute right hemiparesis and sensory axonal neuropathy in the context of an intercurrent viral illness...
  35. Erdmann A, Gao Z, Jung U, Foley J, Borenstein T, Jacobson K, et al. Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo. Blood. 2005;105:4707-14 pubmed
    ..effector T cells, murine type 1 helper T cells (Th1) and type 1 cytotoxic T lymphocytes (Tc1) and Th2/Tc2 cells were generated using an antigen-presenting cell (APC)-free method...
  36. Duan L, Wei L, Tian Y, Zhang Z, Hu P, Wei Q, et al. Novel Susceptibility Loci for Moyamoya Disease Revealed by a Genome-Wide Association Study. Stroke. 2018;49:11-18 pubmed publisher
    ..The association with homocysteine metabolism and the immune system enrichment of susceptibility gene expression suggest that therapeutic interventions targeting these pathways may be effective approaches for MMD treatment. ..
  37. Li N, Seetharam S, Seetharam B. Genomic structure of human transcobalamin II: comparison to human intrinsic factor and transcobalamin I. Biochem Biophys Res Commun. 1995;208:756-64 pubmed
    Human transcobalamin II (TC II) gene was isolated and partially sequenced. The gene is composed of nine exons and eight introns spanning approximately 20 kb...
  38. Garrod M, Allen L, Haan M, Green R, Miller J. Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics. Eur J Clin Nutr. 2010;64:503-9 pubmed publisher
    ..It remains to be determined whether the TC C776G polymorphism has a significant effect on the hematological and neurological manifestations of B12 deficiency or on vascular and other morbidities associated with hyperhomocysteinemia. ..
  39. Capodilupo A, Vergaro V, Baldassarre F, Cardone A, Corrente G, Carlucci C, et al. Thiophene-based fluorescent probes with low cytotoxicity and high photostability for lysosomes in living cells. Biochim Biophys Acta. 2015;1850:385-92 pubmed publisher
    ..Two thiophene-based fluorescent dyes, TC1 and TC2, were synthetized as lysosome-specific probes...
  40. Craciun F, Cordero F, Vasile B, Fruth V, Zaharescu M, Atkinson I, et al. Combined use of Mössbauer spectroscopy, XPS, HRTEM, dielectric and anelastic spectroscopy for estimating incipient phase separation in lead titanate-based multiferroics. Phys Chem Chem Phys. 2018;20:14652-14663 pubmed publisher
    ..between a tetragonal phase T1 free of magnetic clusters and a cubic phase, and a lower transition temperature TC2, below which the cubic phase rich in magnetic clusters is transformed into a tetragonal phase T2...
  41. Schiff M, Ogier de Baulny H, Bard G, Barlogis V, Hamel C, Moat S, et al. Should transcobalamin deficiency be treated aggressively?. J Inherit Metab Dis. 2010;33:223-9 pubmed publisher
    Transcobalamin (transcobalamin II, TC) transports plasma vitamin B(12) (cobalamin, Cbl) into cells...
  42. Trakadis Y, Alfares A, Bodamer O, Buyukavci M, Christodoulou J, Connor P, et al. Update on transcobalamin deficiency: clinical presentation, treatment and outcome. J Inherit Metab Dis. 2014;37:461-73 pubmed publisher
    ..Most centres adjusted the treatment regimen based on monitoring CBC, total plasma homocysteine, plasma and urine methylmalonic acid, as well as, clinical status. Finally, continuing IM treatment into adulthood appears to be beneficial. ..
  43. Balduino Victorino D, de Godoy M, Goloni Bertollo E, Pavarino Ã. Genetic polymorphisms involved in folate metabolism and maternal risk for down syndrome: a meta-analysis. Dis Markers. 2014;2014:517504 pubmed publisher
    ..Finally, considering MTR c.2756A>G (rs1805087), TC2 c.776C>G (rs1801198), and CBS c...
  44. Benoit C, Stanton A, Tartanian A, Motzer A, McGaughey D, Bond S, et al. Functional and phylogenetic characterization of noncanonical vitamin B12-binding proteins in zebrafish suggests involvement in cobalamin transport. J Biol Chem. 2018;293:17606-17621 pubmed publisher
  45. Martinelli M, Scapoli L, Mattei G, Ugolini G, Montroni I, Zattoni D, et al. A candidate gene study of one-carbon metabolism pathway genes and colorectal cancer risk. Br J Nutr. 2013;109:984-9 pubmed publisher
    ..However, an increased risk of CRC was observed for two variant alleles of SNP mapping on the transcobalamin 2 gene (TCN2): C776G (rs1801198) and c.1026-394T>G (rs7286680)...
  46. Fowler R, Vllasaliu D, Falcone F, Garnett M, Smith B, Horsley H, et al. Uptake and transport of B12-conjugated nanoparticles in airway epithelium. J Control Release. 2013;172:374-381 pubmed publisher
    ..our work demonstrates that the bronchial cell line, Calu-3, expresses the B12-intrinsic factor receptor, the transcobalamin II receptor and the transcobalamin II carrier protein...
  47. Morelli E, Leone E, Cantafio M, Di Martino M, Amodio N, Biamonte L, et al. Selective targeting of IRF4 by synthetic microRNA-125b-5p mimics induces anti-multiple myeloma activity in vitro and in vivo. Leukemia. 2015;29:2173-83 pubmed publisher
    ..Moreover, we provide evidence that miR-125b is downregulated in TC2/3 molecular MM subgroups and in established cell lines...
  48. Anuradha R, Munisankar S, Dolla C, Kumaran P, Nutman T, Babu S. Modulation of CD4+ and CD8+ T-Cell Function by Interleukin 19 and Interleukin 24 During Filarial Infections. J Infect Dis. 2016;213:811-5 pubmed publisher
    ..role of IL-19 and IL-24 in regulating T-cell responses, we examined the frequency of T-helper type 1 (Th1)/Tc1, Th2/Tc2, Th9/Tc9, Th17/Tc17, Th22/Tc22, and Tr1 cells in 26 filariae-infected individuals stimulated with filarial antigen ..
  49. Brodeur T, Robidoux T, Weinstein J, Craft J, Swain S, Marshak Rothstein A. IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells. J Immunol. 2015;195:5251-60 pubmed publisher
    ..These pulmonary CD8(+) T cells differentiate into IL-13-producing Tc2 cells and play a major role in a bleomycin-induced model of fibrosis...
  50. Nashabat M, Maegawa G, Nissen P, Nexo E, Al Shamrani H, Al Owain M, et al. Long-term Outcome of 4 Patients With Transcobalamin Deficiency Caused by 2 Novel TCN2 Mutations. J Pediatr Hematol Oncol. 2017;39:e430-e436 pubmed publisher
    ..Patients usually present with macrocytic anemia, pancytopenia, failure to thrive, gastrointestinal symptoms, and neurological dysfunction...
  51. Morais M, Ferreira V, Figueira F, Mendes F, Raposinho P, Santos I, et al. Technetium-99m complexes of l-arginine derivatives for targeting amino acid transporters. Dalton Trans. 2017;46:14537-14547 pubmed publisher
    ..of stable complexes of the type fac-[99mTc(CO)3(k3-L)]+ (Tc1, L = L1; Tc2, L = L2) and of the respective surrogates Re1 and Re2...
  52. Namour F, Helfer A, Quadros E, Alberto J, Bibi H, Orning L, et al. Transcobalamin deficiency due to activation of an intra exonic cryptic splice site. Br J Haematol. 2003;123:915-20 pubmed
    ..Until now, genetic studies have been reported in only five patients with TC deficiency and the molecular defect was different in each of them, which gives evidence for a genetic heterogeneity of the disease. ..
  53. Hartana C, Ahlén Bergman E, Zirakzadeh A, Krantz D, Winerdal M, Winerdal M, et al. Urothelial bladder cancer may suppress perforin expression in CD8+ T cells by an ICAM-1/TGFβ2 mediated pathway. PLoS ONE. 2018;13:e0200079 pubmed publisher
    ..The majority of perforin-deficient CD8+ T cells are effector memory T (TEM) cells with exhausted Tc2 cell phenotype, judged by the presence of PD-1 and GATA-3...
  54. Nunes P, Morais G, Palma E, Silva F, Oliveira M, Ferreira V, et al. Isostructural Re(I)/(99m)Tc(I) tricarbonyl complexes for cancer theranostics. Org Biomol Chem. 2015;13:5182-94 pubmed publisher
    ..and Tc4 presented a faster excretion, as they undergo metabolic transformations, in contrast to complexes Tc1 and Tc2. In summary, our results show that benzothiazole-containing Re(I)/(99m)Tc(I) tricarbonyl complexes stabilized by ..
  55. Hebbar P, Alkayal F, Nizam R, Melhem M, Elkum N, John S, et al. The TCN2 variant of rs9606756 [Ile23Val] acts as risk loci for obesity-related traits and mediates by interacting with Apo-A1. Obesity (Silver Spring). 2017;25:1098-1108 pubmed publisher
    ..The TCN2 variant acts as a risk factor for WC in the Arab population. The variant mediates obesity-related anthropometric traits via interactions with Apo-A1/high-density lipoprotein or TP53. ..
  56. Cao P, Wang Z, Schleimer R, Liu Z. Pathophysiologic mechanisms of chronic rhinosinusitis and their roles in emerging disease endotypes. Ann Allergy Asthma Immunol. 2018;: pubmed publisher
    ..immune response deviation into type 1 (orchestrated by ILC1s, Tc1 and Th1 cells), type 2 (characterized by ILC2s, Tc2 and Th2 cells), and type 3 (mediated by ILC3s, Tc17 and Th17 cells) responses...
  57. Sagarkar S, Bhardwaj P, Storck V, Devers Lamrani M, Martin Laurent F, Kapley A. s-triazine degrading bacterial isolate Arthrobacter sp. AK-YN10, a candidate for bioaugmentation of atrazine contaminated soil. Appl Microbiol Biotechnol. 2016;100:903-13 pubmed publisher
    ..Draft genome sequencing revealed similarity to pAO1, TC1, and TC2 catabolic plasmids of the Arthrobacter taxon...
  58. Kong Y, Wang Y, Cao X, Song Y, Chen Y, Sun Y, et al. Aberrant T cell responses in the bone marrow microenvironment of patients with poor graft function after allogeneic hematopoietic stem cell transplantation. J Transl Med. 2017;15:57 pubmed publisher
    ..of T cell subsets in the bone marrow (BM) immune microenvironment, including Th17, Tc17, Th1, Tc1, Th2, Tc2 cells and regulatory T cells (Tregs), are involved in the pathogenesis of PGF remains unclear...
  59. Wang B, Liu M, Wang Y, Dai J, Tao J, Wang S, et al. Association between SNPs in genes involved in folate metabolism and preterm birth risk. Genet Mol Res. 2015;14:850-9 pubmed publisher
    ..The combined wild-type genotype MTHFD-G1958A, MTR-A2756G, MTRR-A66G, MTHFR-A1298C, NFE2L2-ins1+C11108T, and RFC1-G80A may decrease the risk of preterm birth. ..
  60. Semmler A, Simon M, Moskau S, Linnebank M. The methionine synthase polymorphism c.2756A>G alters susceptibility to glioblastoma multiforme. Cancer Epidemiol Biomarkers Prev. 2006;15:2314-6 pubmed
    ..We investigated MTR c.2756A>G, MTHFR c.677C>T, and a third polymorphism, transcobalamin 2 c.776C>G (P259R), for a potential association with the formation of glioblastoma multiforme. The MTR c...
  61. Vlastos F, Hillas G, Vidal P, Lacomme S, Galateau Salle F, Vollmer E, et al. Survey and biological insights of pemetrexed-related therapeutic improvement in mesothelioma: The Nancy Centre of Biological Resources' Mesothelioma Cohort. J Thorac Oncol. 2009;4:1259-63 pubmed publisher
    ..We also studied a potential link between specific single nucleotide polymorphisms of transcobalamin II (TCII) gene and susceptibility to both asbestos and pemetrexed...
  62. Pupavac M, Tian X, Chu J, Wang G, Feng Y, Chen S, et al. Added value of next generation gene panel analysis for patients with elevated methylmalonic acid and no clinical diagnosis following functional studies of vitamin B12 metabolism. Mol Genet Metab. 2016;117:363-8 pubmed publisher
    ..Thus, the NGS gene panel allowed for the presumptive diagnosis of 8 additional patients for which a diagnosis was not made by the functional assays. ..
  63. Salvarese N, Spolaore B, Marangoni S, Pasin A, Galenda A, Tamburini S, et al. Transglutaminase-mediated conjugation and nitride-technetium-99m labelling of a bis(thiosemicarbazone) bifunctional chelator. J Inorg Biochem. 2018;183:18-31 pubmed publisher
    ..sup>99mTc1) and [99mTc][Tc(N)(ATSM/A-ε-Ahx-SP)] (99mTc2)...
  64. Knobloch J, Yakin Y, Körber S, Grensemann B, Bendella Z, Boyaci N, et al. Simvastatin requires activation in accessory cells to modulate T-cell responses in asthma and COPD. Eur J Pharmacol. 2016;788:294-305 pubmed publisher
    ..macrophages (AM) or in peripheral blood mononuclear cells (PBMCs), were ex vivo activated towards Th1/Tc1 or Th2/Tc2 and incubated with simvastatin...
  65. Salazar Castañón V, Juarez Avelar I, Legorreta Herrera M, Govezensky T, Rodriguez Sosa M. Co-infection: the outcome of Plasmodium infection differs according to the time of pre-existing helminth infection. Parasitol Res. 2018;117:2767-2784 pubmed publisher
    ..At 2 (Tc2) or 8 (Tc8) weeks post-infection, mice were intravenously infected with 1 × 103 Plasmodium yoelii (..
  66. Horn L, Gettinger S, Gordon M, Herbst R, Gandhi L, Felip E, et al. Safety and clinical activity of atezolizumab monotherapy in metastatic non-small-cell lung cancer: final results from a phase I study. Eur J Cancer. 2018;101:201-209 pubmed publisher
    ..was 50% (95% confidence interval [CI], 28%-72%), 33% (20%-48%), 29% (18%-41%) and 11% (1%-35%) for the TC3 or IC3, TC2/3 or IC2/3, TC1/2/3 or IC1/2/3 and TC0 and IC0 subgroups, respectively. All-patient ORR was 23% (95% CI, 14%-33%)...
  67. Bonilla C, Lawlor D, Taylor A, Gunnell D, Ben Shlomo Y, Ness A, et al. Vitamin B-12 status during pregnancy and child's IQ at age 8: a Mendelian randomization study in the Avon longitudinal study of parents and children. PLoS ONE. 2012;7:e51084 pubmed publisher
    ..Our findings suggest that maternal vitamin B-12 may not have an important effect on offspring cognitive ability. However, further examination of this issue is warranted. ..
  68. Kim H, Lee J, Nam S, Ock C, Moon J, Yoo C, et al. Association of PD-L1 Expression with Tumor-Infiltrating Immune Cells and Mutation Burden in High-Grade Neuroendocrine Carcinoma of the Lung. J Thorac Oncol. 2018;13:636-648 pubmed publisher
    ..follows: TC0 and IC0 were defined as PD-L1 expression less than 1%, TC1 and IC1 as at least 1% but less than 10%, TC2 and IC2 as 10% or more but less than 50%, and TC3 and IC3 as 50% or more...
  69. Zhao X, Long J, Liang F, Liu N, Sun Y, Xi Y. Vaccination with a Novel Antigen-specific Tolerizing DNA Vaccine Encoding CCOL2A1 Protects Rats from Experimental Rheumatoid Arthritis. Hum Gene Ther. 2018;: pubmed publisher
    ..with pcDNA-CCOL2A1 markedly decreased serum contens of anti-CII IgG antibodies, induced Th1-to-Th2 and Tc1-to-Tc2 shifts, and decreased the percentages of CD4+CD29+ and Th17 T cells...
  70. Chen J, Lu W, Zhao M, Cao X, Jiang Y, Jin X, et al. Reactive oxygen species mediated T lymphocyte abnormalities in an iron-overloaded mouse model and iron-overloaded patients with myelodysplastic syndromes. Ann Hematol. 2017;96:1085-1095 pubmed publisher
    ..showed that iron overload could reduce the percentage of CD3+ T cells and the ratio of Th1/Th2 and Tc1/Tc2 but increase the percentage of regulatory T (Treg) cells and the ratio of CD4/CD8...
  71. Spigel D, Chaft J, Gettinger S, Chao B, Dirix L, Schmid P, et al. FIR: Efficacy, Safety, and Biomarker Analysis of a Phase II Open-Label Study of Atezolizumab in PD-L1-Selected Patients With NSCLC. J Thorac Oncol. 2018;13:1733-1742 pubmed publisher
    ..Patients with PD-L1 TC2/3 (PD-L1 staining on ≥5% of TC) or IC2/3 tumors (PD-L1 staining on ≥5% of IC; determined by SP142 PD-L1 ..
  72. Barbosa P, Stabler S, Trentin R, Carvalho F, Luchessi A, Hirata R, et al. Evaluation of nutritional and genetic determinants of total homocysteine, methylmalonic acid and S-adenosylmethionine/S-adenosylhomocysteine values in Brazilian childbearing-age women. Clin Chim Acta. 2008;388:139-47 pubmed
    ..The genotypes for MTHFR C677T, MTHFR A1298C, MTR A2756G, MTRR A66G, TC2 C776G, TC2 A67G and RFC1 A80G gene polymorphisms were identified by PCR-RFLP...
  73. Schrempf W, Eulitz M, Neumeister V, Siegert G, Koch R, Reichmann H, et al. Utility of measuring vitamin B12 and its active fraction, holotranscobalamin, in neurological vitamin B12 deficiency syndromes. J Neurol. 2011;258:393-401 pubmed publisher
    ..Neither test can be recommended to diagnose VitB(12) deficiency in subjects with neuropsychiatric disorders. ..
  74. Linnebank M, Moskau S, Kowoll A, Semmler A, Bangard C, Vogt Schaden M, et al. Association of transcobalamin c. 776C>G with overall survival in patients with primary central nervous system lymphoma. Br J Cancer. 2012;107:1840-3 pubmed publisher
    ..Younger age (Wald=8.9; P=0.003) and the wild-type C (CC) allele of the genotype transcobalamin c (Tc2). 776C>G (Wald=6.7; P=0...
  75. Marini N, Yang W, Asrani K, Witte J, Rine J, Lammer E, et al. Sequence variation in folate pathway genes and risks of human cleft lip with or without cleft palate. Am J Med Genet A. 2016;170:2777-2787 pubmed publisher
    ..8, 95%CI?=?1.2-6.3). This comprehensive study provides further direction on candidate loci to help disentangle the folate-related developmental phenomena in human clefting risk. © 2016 Wiley Periodicals, Inc. ..
  76. Giusti B, Saracini C, Bolli P, Magi A, Sestini I, Sticchi E, et al. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. J Med Genet. 2008;45:721-30 pubmed publisher
    ..Our findings offer new insights into the pathogenesis of AAA. ..
  77. Williams D, Flood M. Capillary tone: cyclooxygenase, shear stress, luminal glycocalyx, and hydraulic conductivity (Lp). Physiol Rep. 2015;3: pubmed publisher
    ..Three distinct responses of Lp to indomethacin (TC2) were demonstrated (TC1 and TC2 medians: Test Subgroup 1, 3.0 vs. 1.8; Test Subgroup 2, 18.2 vs. 2...
  78. Wang Y, Kong Y, Song Y, Han W, Zhang Y, Zhang X, et al. Increased Type 1 Immune Response in the Bone Marrow Immune Microenvironment of Patients with Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2016;22:1376-1382 pubmed publisher
    ..The Th1, Th2, Tc1, Tc2, and active phenotypes were analyzed by flow cytometry...
  79. Della Bella C, Benagiano M, De Gennaro M, Gomez Morales M, Ludovisi A, D Elios S, et al. T-cell clones in human trichinellosis: Evidence for a mixed Th1/Th2 response. Parasite Immunol. 2017;39: pubmed publisher
    ..In the series of the 11 TsES-specific CD8+ T-cell clones, 18% were Tc2, 45% Tc0 and 36% Tc1...
  80. Li N, Rosenblatt D, Kamen B, Seetharam S, Seetharam B. Identification of two mutant alleles of transcobalamin II in an affected family. Hum Mol Genet. 1994;3:1835-40 pubmed
    b>Transcobalamin II (TC II) deficiency is a rare autosomal recessive disease leading to cobalamin (Cbl; Vitamin B12) deficiency characterized by failure to thrive, megaloblastic anemia, impaired immunodefence and neurological ..
  81. Li N, Seetharam S, Lindemans J, Alpers D, Arwert F, Seetharam B. Isolation and sequence analysis of variant forms of human transcobalamin II. Biochim Biophys Acta. 1993;1172:21-30 pubmed
    Two cDNA clones (1.9 kb and 1.5 kb, respectively) encoding full length human TC II have been isolated from a human endothelial cell cDNA library and sequenced...
  82. Biselli J, Brumati D, Frigeri V, Zampieri B, Goloni Bertollo E, Pavarino Bertelli E. A80G polymorphism of reduced folate carrier 1 (RFC1) and C776G polymorphism of transcobalamin 2 (TC2) genes in Down's syndrome etiology. Sao Paulo Med J. 2008;126:329-32 pubmed
    ..the A80G polymorphism of the reduced folate carrier 1 (RFC1) gene and the C776G polymorphism of the transcobalamin 2 (TC2) gene as maternal risk factors for DS among Brazilian women...
  83. Cascalheira J, Gonçalves M, Barroso M, Castro R, Palmeira M, Serpa A, et al. Association of the transcobalamin II gene 776C → G polymorphism with Alzheimer's type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A → C polymorphism genotype. Ann Clin Biochem. 2015;52:448-55 pubmed publisher
    Decreased serum concentrations of vitamin B12 are associated with Alzheimer's type dementia. The transcobalamin II gene (TCN2) 776C → G polymorphism affects transcobalamin II function as a carrier of vitamin B12 and might modify ..
  84. Yang Q, Cheng X, Wang Y, Wang B, Wang Z, Gao S. Two-step magnetic switching in a mononuclear iron(II) complex around room temperature. Dalton Trans. 2015;44:8938-41 pubmed publisher
    ..It displays a new example of two-step SCO with Tc1↓ = 250 K, Tc1↑ = 260 K and Tc2 = 295 K.
  85. Platica O, Janeczko R, Quadros E, Regec A, Romain R, Rothenberg S. The cDNA sequence and the deduced amino acid sequence of human transcobalamin II show homology with rat intrinsic factor and human transcobalamin I. J Biol Chem. 1991;266:7860-3 pubmed
    The cellular uptake of cobalamin (Cbl, vitamin B12) is mediated by transcobalamin II (TCII), a plasma protein that binds Cbl and is secreted by human umbilical vein endothelial (HUVE) cells...
  86. Mills J, Carter T, Kay D, Browne M, Brody L, Liu A, et al. Folate and vitamin B12-related genes and risk for omphalocele. Hum Genet. 2012;131:739-46 pubmed publisher
    ..Our data, if confirmed, suggest that supplements containing both folic acid and vitamin B12 may be beneficial in preventing omphaloceles. ..
  87. Annunziato F, Romagnani C, Romagnani S. The 3 major types of innate and adaptive cell-mediated effector immunity. J Allergy Clin Immunol. 2015;135:626-35 pubmed publisher
    ..Type 2 immunity consists of GATA-3(+) ILC2s, TC2 cells, and TH2 cells producing IL-4, IL-5, and IL-13, which induce mast cell, basophil, and eosinophil activation, ..
  88. Czarnowicki T, Gonzalez J, Shemer A, Malajian D, Xu H, Zheng X, et al. Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population. J Allergy Clin Immunol. 2015;136:104-115.e7 pubmed publisher
    ..We measured increased TH2/TC2/IL-13(+) and TH22/TC22/IL-22(+) populations (P < ...
  89. Mills J, Druschel C, Pangilinan F, Pass K, Cox C, Seltzer R, et al. Folate-related genes and omphalocele. Am J Med Genet A. 2005;136:8-11 pubmed
    ..MTHFR), methylenetetrahydrofolate dehydrogenase (MTHFD1), the reduced folate carrier (SLC19A1), and transcobalamin II (TCN2) were examined in 25 children with euploid omphalocele and 59 matched controls...
  90. Lahner E, Gentile G, Purchiaroni F, Mora B, Simmaco M, Annibale B. Single nucleotide polymorphisms related to vitamin B12 serum levels in autoimmune gastritis patients with or without pernicious anaemia. Dig Liver Dis. 2015;47:285-90 pubmed publisher
  91. Ma J, Shi L, Deng Y, Wang H, Cao P, Long X, et al. CD8(+) T cells with distinct cytokine-producing features and low cytotoxic activity in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps. Clin Exp Allergy. 2016;46:1162-75 pubmed publisher
    ..Compared with controls, elevated percentages of total CD8(+) T cells and cytotoxic T lymphocyte (Tc) 1 (IFN-?(+) ), Tc2 (IL-4(+) ), and Tc17 (IL-17A(+) ) cell subset, and decreased percentages of FOXP3(+) CD8(+) regulatory T cells, ..
  92. Gu W, Zhang Q, Zhu W, Guo Y, Zhang L. [Imbalance of Tc and Th in Peripheral Blood of Patients with Systemic Lupus Erythematosus and Its Significance]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:1533-1538 pubmed publisher
    To investigate the imbalance of Tc1/Tc2,Th1/Th2 and Tc/Th in patients with systemic lupus erythematosus(SLE) and its relationship with the clinical stages of SLE...