TRAF3IP2

Summary

Gene Symbol: TRAF3IP2
Description: TRAF3 interacting protein 2
Alias: ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, PSORS13, adapter protein CIKS, NFkB-activating protein ACT1, connection to IKK and SAPK/JNK, nuclear factor NF-kappa-B activator 1
Species: human
Products:     TRAF3IP2

Top Publications

  1. Li X, Commane M, Nie H, Hua X, Chatterjee Kishore M, Wald D, et al. Act1, an NF-kappa B-activating protein. Proc Natl Acad Sci U S A. 2000;97:10489-93 pubmed
    Use of an NF-kappaB-dependent selectable marker facilitated the isolation of a cell line containing a cDNA encoding Act1, an NF-kappaB activator...
  2. Qian Y, Liu C, Hartupee J, Altuntas C, Gulen M, Jane wit D, et al. The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol. 2007;8:247-56 pubmed
    ..We report here the essential involvement of the adaptor protein Act1 in IL-17 receptor (IL-17R) signaling and IL-17-dependent immune responses...
  3. Ellinghaus E, Ellinghaus D, Stuart P, Nair R, Debrus S, Raelson J, et al. Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet. 2010;42:991-5 pubmed publisher
    ..We identified an association at TRAF3IP2 on 6q21 and genotyped two SNPs at this locus in two additional replication panels (the combined discovery and ..
  4. Strange A, Capon F, Spencer C, Knight J, Weale M, Allen M, et al. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet. 2010;42:985-90 pubmed publisher
    ..Seven loci harbored genes with recognized immune functions (IL28RA, REL, IFIH1, ERAP1, TRAF3IP2, NFKBIA and TYK2)...
  5. Böhm B, Burkhardt H, Uebe S, Apel M, Behrens F, Reis A, et al. Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization. Arthritis Res Ther. 2012;14:R84 pubmed publisher
    ..association studies for psoriatic arthritis (PsA) and psoriasis vulgaris, common coding variants in the TRAF3IP2 gene were identified to contribute to susceptibility to both disease entities. The risk allele of p...
  6. Huffmeier U, Uebe S, Ekici A, Bowes J, Giardina E, Korendowych E, et al. Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. Nat Genet. 2010;42:996-9 pubmed publisher
    ..We replicated PsA associations at HLA-C and IL12B and identified a new association at TRAF3IP2 (rs13190932, P = 8.56 × 10?¹?)...
  7. Sun D, Novotny M, Bulek K, Liu C, Li X, Hamilton T. Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF). Nat Immunol. 2011;12:853-60 pubmed publisher
    ..IL-17 enhanced the stability of chemokine CXCL1 mRNA and other mRNAs through a pathway that involved the adaptor Act1, the adaptors TRAF2 or TRAF5 and the splicing factor SF2 (also known as alternative splicing factor (ASF))...
  8. Kanamori M, Kai C, Hayashizaki Y, Suzuki H. NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6. FEBS Lett. 2002;532:241-6 pubmed
    NF-kappaB activator 1 (Act1), also called CIKS, is a recently identified protein with NF-kappaB and AP-1 activation activities through its association with the IkappaB kinase complex...
  9. Perricone C, Ciccacci C, Ceccarelli F, Di Fusco D, Spinelli F, Cipriano E, et al. TRAF3IP2 gene and systemic lupus erythematosus: association with disease susceptibility and pericarditis development. Immunogenetics. 2013;65:703-9 pubmed publisher
    ..b>TRAF3IP2 gene, associated with susceptibility to psoriatic arthritis and psoriasis, encodes for Act1, a negative regulator ..

More Information

Publications105 found, 100 shown here

  1. Ma C, Lin W, Liu Z, Tang W, Gautam R, Li H, et al. NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3. EMBO Rep. 2017;18:586-602 pubmed publisher
    ..NDR1 interacts with TRAF3 and prevents its binding to IL-17R, which promotes the formation of an IL-17R-Act1-TRAF6 complex and downstream signaling...
  2. Kim K, Kim H, Kim B, Cho M, Lee S. Th17 cytokines regulate osteoclastogenesis in rheumatoid arthritis. Am J Pathol. 2015;185:3011-24 pubmed publisher
    ..the expression of Rankl mRNA in RA FLS, and the IL-17-induced RANKL expression decreased by the inhibition of Act1, tumor necrosis factor receptor-associated factor 6, NF-κB, and activator protein-1...
  3. González C, Godoy L, Ganga M. Identification of a second PAD1 in Brettanomyces bruxellensis LAMAP2480. Antonie Van Leeuwenhoek. 2017;110:291-296 pubmed publisher
    ..bruxellensis ACT1 promoter, encodes an enzyme with coumarate decarboxylase activity...
  4. Ling Y, Puel A. IL-17 and infections. Actas Dermosifiliogr. 2014;105 Suppl 1:34-40 pubmed publisher
    ..Indeed, patients with AD IL-17F deficiency or AR IL-17RA or ACT1 deficiency display CMC and, to a lesser extent, superficial staphylococcal diseases...
  5. Mucci M, Cuestas M, Landanburu M, Mujica M. Prevalence of Candida albicans, Candida dubliniensis and Candida africana in pregnant women suffering from vulvovaginal candidiasis in Argentina. Rev Iberoam Micol. 2017;34:72-76 pubmed publisher
    ..Molecular assays were carried out using specific PCR to amplify the ACT1-associated intron sequence of C. dubliniensis...
  6. Nadai C, Campanaro S, Giacomini A, Corich V. Selection and validation of reference genes for quantitative real-time PCR studies during Saccharomyces cerevisiae alcoholic fermentation in the presence of sulfite. Int J Food Microbiol. 2015;215:49-56 pubmed publisher
    ..The most popular reference gene ACT1, widely used for S...
  7. Sukhov A, Adamopoulos I, Maverakis E. Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review. Clin Rev Allergy Immunol. 2016;51:87-99 pubmed publisher
    ..In addition, there are numerous other genetic susceptibility loci (LCE3, CARD14, NOS2, NFKBIA, PSMA6, ERAP1, TRAF3IP2, IL12RB2, IL23R, IL12B, TNIP1, TNFAIP3, TYK2) and geoepidemiologic factors that contribute to the wide ..
  8. Nenasheva V, Kovaleva G, Uryvaev L, Ionova K, Dedova A, Vorkunova G, et al. Enhanced expression of trim14 gene suppressed Sindbis virus reproduction and modulated the transcription of a large number of genes of innate immunity. Immunol Res. 2015;62:255-62 pubmed publisher
    ..transcription of 18 genes (ifna, il6 (ifnβ2), isg15, raf-1, NF-kB (nf-kb1, rela, nf-kb2, relb), grb2, grb3-3, traf3ip2, junB, c-myb, pu.1, akt1, tyk2, erk2, mek2) and lowered transcription of 3 genes (ifnγ, gata1, il-17a)...
  9. Fabbri C, Serretti A. Genetics of long-term treatment outcome in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2016;65:17-24 pubmed publisher
    ..Promising findings without previous strong evidence were TRAF3IP2-AS1, NFYC, RNLS, KCNJ2, RASGRF1, NTF3 genes...
  10. Kaur M, Panikkath D, Yan X, Liu Z, Berel D, Li D, et al. Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway. Inflamm Bowel Dis. 2016;22:862-9 pubmed publisher
    ..008) antibody levels. pCD was associated with known inflammatory bowel disease loci, including KIF3B, CRTC3, TRAF3IP2, JAZF1, NRIP1, MST1, FUT2, and PTGER (all P < 0.05)...
  11. Ju Y, Dang E, Yang C, Song H. [Progress in genetic research on psoriatic arthritis]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017;34:606-610 pubmed publisher
    ..have been associated with psoriasis vulgaris and psoriatic arthritis, which included MHC, TNF, LCE, IL23R, IL12B, TRAF3IP2 and TNFAIP3, though some, such as MHC, IL-13 and PTPN22, have been specifically associated with psoriatic ..
  12. Li M, Wang B, Sun X, Tang Y, Wei X, Ge B, et al. Upregulation of Intestinal Barrier Function in Mice with DSS-Induced Colitis by a Defined Bacterial Consortium Is Associated with Expansion of IL-17A Producing Gamma Delta T Cells. Front Immunol. 2017;8:824 pubmed publisher
    ..by ??T cells, and it might be responsible for the upregulation of mucosal barrier function through IL-17R-ACT1-mediated recovery of the disrupted occludin subcellular location...
  13. Wang M, Zhang S, Zheng G, Huang J, Songyang Z, Zhao X, et al. Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A. Immunity. 2018;49:66-79.e5 pubmed publisher
    ..CARMA2, mainly expressed in keratinocytes, associates with the ACT1-TRAF6 signaling complex and mediates IL-17A-induced NF-?B and MAPK signaling pathway activation, which leads to ..
  14. Watanabe S, Tan D, Lakshminarasimhan M, Washburn M, Hong E, Walz T, et al. Structural analyses of the chromatin remodelling enzymes INO80-C and SWR-C. Nat Commun. 2015;6:7108 pubmed publisher
    ..EM studies define the position of the Arp8/Arp4/Act1 module within INO80-C, and we find that this module enhances nucleosome-binding affinity but is largely dispensable ..
  15. Chenuet P, Fauconnier L, Madouri F, Marchiol T, Rouxel N, Ledru A, et al. Neutralization of either IL-17A or IL-17F is sufficient to inhibit house dust mite induced allergic asthma in mice. Clin Sci (Lond). 2017;131:2533-2548 pubmed publisher
    ..CXCL1 and IL-6 expression and the response to IL-17A and IL-17F relied on IL-17RA signaling via the adaptor protein act1 in fibroblasts...
  16. Karakadze M, Hirt P, Wikramanayake T. The Genetic Basis of Seborrheic Dermatitis: A Review. J Eur Acad Dermatol Venereol. 2017;: pubmed publisher
    ..Most of the encoded proteins play a role either in the immune response (ACT1, C5, IKBKG/NEMO, STK4, 2C TCR) or epidermal differentiation (ZNF750, MPZL3)...
  17. Yu N, Xu X, Qi G, Liu D, Chen X, Ran X, et al. Ctenopharyngodon idella TBK1 activates innate immune response via IRF7. Fish Shellfish Immunol. 2018;80:521-527 pubmed publisher
    ..IRF3 acted as a stronger positive regulator of IFN and ISG transcription in Ctenopharyngodon idella kidney cells (CIKs). It is suggested the potential function differentiation between IRF3 and IRF7 upon LPS infection in fish...
  18. Urubschurov V, Büsing K, Janczyk P, Souffrant W, Zeyner A. Development and Evaluation of qPCR Assay for Quantitation of Kazachstania slooffiae and Total Yeasts Occurring in the Porcine Gut. Curr Microbiol. 2015;71:373-81 pubmed publisher
    ..984, P < 0.0001) with cultivation results. From two primer sets developed, one set encoding act1 gene was suitable for quantitation of K. slooffiae. The copy numbers of K...
  19. Tsoi L, Spain S, Ellinghaus E, Stuart P, Capon F, Knight J, et al. Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci. Nat Commun. 2015;6:7001 pubmed publisher
    ..3), NFKBIZ (3q12.3) and CAMK2G (10q22.2). We further demonstrate that NFKBIZ is a TRAF3IP2-dependent target of IL-17 signalling in human skin keratinocytes, thereby functionally linking two strong ..
  20. Checa J, Jaklitsch W, Blanco M, Moreno G, Olariaga I, Tello S, et al. Two new species of Thyronectria from Mediterranean Europe. Mycologia. 2015;107:1314-22 pubmed publisher
    ..as determined by multigene phylogenetic analyses of a matrix containing six loci (ITS and 28S regions of nuc rDNA, ACT1, RPB1, RPB2, TEF1 and TUB2 genes)...
  21. Kirsner R, Baquerizo Nole K, Fox J, Liu S. Healing refractory venous ulcers: new treatments offer hope. J Invest Dermatol. 2015;135:19-23 pubmed publisher
    ..2014) report findings of a small phase II trial performed in Indian patients with chronic VLUs, reporting that ACT1, a mimetic peptide of Cx43, accelerates healing in the treatment group...
  22. Rula S, Suwa T, Kijima S, Haraguchi T, Wakatsuki S, Sato N, et al. Measurement of enzymatic and motile activities of Arabidopsis myosins by using Arabidopsis actins. Biochem Biophys Res Commun. 2018;495:2145-2151 pubmed publisher
    ..isoforms (MYA2, XI-B), and one Arabidopsis myosin VIII isoform (ATM1), by using three Arabidopsis actin isoforms (ACT1, ACT2, and ACT7). The measured activities were different from those measured by using muscle actin...
  23. Hálová M, Gahura O, Prevorovský M, Cit Z, Novotny M, Valentová A, et al. Nineteen complex-related factor Prp45 is required for the early stages of cotranscriptional spliceosome assembly. RNA. 2017;23:1512-1524 pubmed publisher
    ..we determined the presence of early spliceosome assembly factors and snRNP complexes along the ECM33 and ACT1 genes...
  24. Wang L, Hu X, Xu Y, Liu Z. Arsenic trioxide inhibits lung metastasis of mouse colon cancer via reducing the infiltration of regulatory T cells. Tumour Biol. 2016;37:15165-15173 pubmed
    ..local lung metastasis of mouse colon cancer in vivo and the regulation of Tregs in cytokine-induced killer cells (CIKs) in vitro...
  25. Zhang S, Yu N, Zhang R, Zhang S, Wu J. Interleukin-17A Induces IL-1β Secretion From RPE Cells Via the NLRP3 Inflammasome. Invest Ophthalmol Vis Sci. 2016;57:312-9 pubmed publisher
    ..Expression patterns of IL-17 receptor A (IL-17RA), IL-17 receptor C (IL-17RC), and ACT1 were analyzed by RT-PCR, flow cytometry, and immunofluorescence...
  26. Ciccacci C, Latini A, Politi C, Mancinelli S, Marazzi M, Novelli G, et al. Impact of glutathione transferases genes polymorphisms in nevirapine adverse reactions: a possible role for GSTM1 in SJS/TEN susceptibility. Eur J Clin Pharmacol. 2017;73:1253-1259 pubmed publisher
    ..in controls, including the GSTM1 null genotype and four previously identified risk alleles in CYP2B6, HCP5, and TRAF3IP2 genes. Among patients, 27 had developed SJS/TEN and 76 had developed hepatotoxicity during the treatment...
  27. Gao J, Wallis J, Browse J. Mutations in the Prokaryotic Pathway Rescue the fatty acid biosynthesis1 Mutant in the Cold. Plant Physiol. 2015;169:442-52 pubmed publisher
    ..Here, we report the identification of two suppressor mutations, one in act1, which encodes the chloroplast acyl-ACP:glycerol-3-phosphate acyltransferase, and one in lpat1, which encodes the ..
  28. Wang L, Yi Y, Yin D, Zhou Z, Fan J, Ye W, et al. Augmented CD3(+)CD8(+) and CD3(+)CD56(-) cells in cytokine-induced killer cells cultured with engineered cells for costimulatory enhancement from heavily pretreated patients with solid tumor. Cytotherapy. 2016;18:581-9 pubmed publisher
    Cytokine-induced killer cells (CIKs) were shown to be a promising tool in the quest for new therapeutic approaches in the setting of metastatic solid tumors refractory to standard treatments...
  29. Ciccacci C, Perricone C, Politi C, Rufini S, Ceccarelli F, Cipriano E, et al. A polymorphism upstream MIR1279 gene is associated with pericarditis development in Systemic Lupus Erythematosus and contributes to definition of a genetic risk profile for this complication. Lupus. 2017;26:841-848 pubmed publisher
    Recently, a study has shown that a polymorphism in the region of MIR1279 modulates the expression of the TRAF3IP2 gene...
  30. Whitelaw J, Latorre Barragan F, Gras S, Pall G, Leung J, Heaslip A, et al. Surface attachment, promoted by the actomyosin system of Toxoplasma gondii is important for efficient gliding motility and invasion. BMC Biol. 2017;15:1 pubmed publisher
    ..phenotypes (apicoplast segregation, host cell egress, dense granule motility) appeared early after induction of the act1 knockout and went to completion, a small percentage of the parasites remained capable of motility and invasion well ..
  31. Valente A, Yoshida T, Clark R, Delafontaine P, Siebenlist U, Chandrasekar B. Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling. Free Radic Biol Med. 2013;60:125-35 pubmed publisher
    ..Notably, TRAF3-interacting protein 2 (TRAF3IP2; also known as CIKS or Act1) knockdown blunted AOPP-induced apoptosis...
  32. Herjan T, Yao P, Qian W, Li X, Liu C, Bulek K, et al. HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization. J Immunol. 2013;191:640-9 pubmed publisher
    ..In this study, we report a new function of RNA-binding protein HuR in IL-17-induced Act1-mediated chemokine mRNA stabilization...
  33. Grek C, Montgomery J, Sharma M, Ravi A, Rajkumar J, Moyer K, et al. A Multicenter Randomized Controlled Trial Evaluating a Cx43-Mimetic Peptide in Cutaneous Scarring. J Invest Dermatol. 2017;137:620-630 pubmed publisher
    ..b>aCT1 is a Cx43 mimetic peptide that in preclinical studies accelerated wound closure, decreased inflammation and ..
  34. Wang L, Wang R, Fan L, Liang W, Liang K, Xu Y, et al. Arsenic trioxide is an immune adjuvant in liver cancer treatment. Mol Immunol. 2017;81:118-126 pubmed publisher
    ..on the immune status in hepatic cancer and its in vitro regulatory role in cytokine-induced killers(CIKs)cytotoxicity...
  35. Wang Y, Min X, Ge X. [Mechanism of Regulating BAFF Signaling Pathway by Act1 in B Cell Lymphoma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:1787-1792 pubmed publisher
    To explore the mechanism of regulating B cell-activating factor (BAFF) signalling pathway by NF-?B activator 1 (Act1) in B cell lymphoma so as to provide a new thinking for treatment of B cell lymphoma...
  36. Bayat N, Ebrahimi Barough S, Norouzi Javidan A, Saberi H, Ardakan M, Ai A, et al. Anti-inflammatory Effects of Atorvastatin by Suppressing TRAF3IP2 and IL-17RA in Human Glioblastoma Spheroids Cultured in a Three-dimensional Model: Possible Relevance to Glioblastoma Treatment. Mol Neurobiol. 2018;55:2102-2110 pubmed publisher
    ..A mechanistic insight into the role of IL-17RA, TRAF3IP2, and apoptotic genes in progression of glioma could provide an important way for therapy of malignant tumors with ..
  37. Aroor A, Habibi J, Kandikattu H, Garro Kacher M, Barron B, Chen D, et al. Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice. Cardiovasc Diabetol. 2017;16:61 pubmed publisher
    ..Further, WD upregulated the expression of TRAF3IP2, a cytoplasmic adapter molecule and a regulator of multiple inflammatory mediators...
  38. Liu D, Li X, Shen D, Novick P. Two subunits of the exocyst, Sec3p and Exo70p, can function exclusively on the plasma membrane. Mol Biol Cell. 2018;29:736-750 pubmed publisher
    ..Blocking actin-dependent delivery of secretory vesicles in act1-3 cells results in loss of Sec3p from the purified complex...
  39. Rosani U, Varotto L, Gerdol M, Pallavicini A, Venier P. IL-17 signaling components in bivalves: Comparative sequence analysis and involvement in the immune responses. Dev Comp Immunol. 2015;52:255-68 pubmed publisher
    ..59 domains uniquely identifying interleukin 17 (IL-17) and 96 SEFIR domains typical of IL-17 receptors and CIKS/ACT1 proteins acting downstream in the IL-17 signaling pathway...
  40. Staniszewska M, Bondaryk M, Zukowski K, Chudy M. Role of SAP7-10 and Morphological Regulators (EFG1, CPH1) in Candida albicans' Hypha Formation and Adhesion to Colorectal Carcinoma Caco-2. Pol J Microbiol. 2015;64:203-10 pubmed
    ..SAP7 expression was analyzed using real time RT-PCR; relative quantification was normalized against ACT1 in cells after growth on Caco-2. Adherence assay of C. albicans to Caco-2 was performed in a 24-well-plate...
  41. Zhang P, Liu J, Tan B, Zhu F, Fang L. [Hypercoagulable state is associated with NF-kappa B activation and increased inflammatory factors in patients with rheumatoid arthritis]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:364-8 pubmed
    ..Interleukin-10 (IL-10), IL-6, IL-4, IL-17, NF-κB activator 1 (Act1), p50, p65, IκBα, platelet activating factor (PAF), PAF-acetylhydrolase (PAF-AH) and anti-cyclic ..
  42. Huang F, Kao C, Wachi S, Thai P, Ryu J, Wu R. Requirement for both JAK-mediated PI3K signaling and ACT1/TRAF6/TAK1-dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells. J Immunol. 2007;179:6504-13 pubmed
    ..STIR (similar expression to fibroblast growth factor and IL-17R; Toll-IL-1R)-related signaling molecules, such as Act1, TNFR-associated factor 6 (TRAF6), and TGF-beta-activated kinase 1 (TAK1), and transfection of A52R, an inhibitor ..
  43. Sønder S, Paun A, Ha H, Johnson P, Siebenlist U. CIKS/Act1-mediated signaling by IL-17 cytokines in context: implications for how a CIKS gene variant may predispose to psoriasis. J Immunol. 2012;188:5906-14 pubmed publisher
    ..cytokines signal via the adaptor protein connection to IκB kinase and stress-activated protein kinases (CIKS)/Act1. Psoriasis is a disease with a strong genetic predisposition, and the gene encoding CIKS has recently been ..
  44. Zheng Y, Hu B, Xie S, Chen X, Hu Y, Chen W, et al. Dendritic cells infected by Ad-sh-SOCS1 enhance cytokine-induced killer (CIK) cell immunotherapeutic efficacy in cervical cancer models. Cytotherapy. 2017;19:617-628 pubmed publisher
    ..The DCs infected by Ad-sh-SOCS1 (gmDCs) and CIKs were then co-cultured for 5 or 9 days, and CIK proliferation and antitumor activity were evaluated both in vitro ..
  45. Alonso G, Pavarina A, Sousa T, Klein M. A quest to find good primers for gene expression analysis of Candida albicans from clinical samples. J Microbiol Methods. 2018;147:1-13 pubmed publisher
    ..albicans virulence genes: ALS1, CAP1, CAT1, EFG1, HWP1, LIP3, PLB1, SAP1, SAP4, SOD1, SOD5 and ACT1 (normalizing gene)...
  46. Bannon M, Savonen C, Jia H, Dachet F, Halter S, Schmidt C, et al. Identification of long noncoding RNAs dysregulated in the midbrain of human cocaine abusers. J Neurochem. 2015;135:50-9 pubmed publisher
    ..antisense lncRNA, tumor necrosis factor receptor-associated factor 3-interacting protein 2-antisense 1 (TRAF3IP2-AS1), was found predominantly in the nucleus of human dopamine (DA) neurons, whereas the related TRAF3IP2 protein-..
  47. Luo H, Gong L, Zhu B, Huang Y, Tang C, Yu S, et al. Therapeutic outcomes of autologous CIK cells as a maintenance therapy in the treatment of lung cancer patients: A retrospective study. Biomed Pharmacother. 2016;84:987-993 pubmed publisher
    Few clinical studies have confirmed the role of cytokine-induced killer cells (CIKs) in the maintenance therapy of advanced lung cancer patients...
  48. Qian Y, Zhao Z, Jiang Z, Li X. Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells. Proc Natl Acad Sci U S A. 2002;99:9386-91 pubmed
    ..Overexpression of the NF kappa B activator 1 (Act1) leads to the activation of both NF kappa B and Jun kinase in epithelial cell lines...
  49. Garg A, Ahmed M, Vallejo A, Ma A, Gaffen S. The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling. Sci Signal. 2013;6:ra44 pubmed publisher
    ..Together, these data describe a mechanism of restraining IL-17 signaling and reveal an aspect of A20 activity that may help to explain its role in autoimmunity in humans. ..
  50. Xiang Q, Chen L, Hou S, Fang J, Zhou Y, Bai L, et al. TRAF5 and TRAF3IP2 gene polymorphisms are associated with Behçet's disease and Vogt-Koyanagi-Harada syndrome: a case-control study. PLoS ONE. 2014;9:e84214 pubmed publisher
    TRAF5 and TRAF3IP2 have been reported to be associated with several autoimmune diseases...
  51. Yariswamy M, Yoshida T, Valente A, Kandikattu H, Sakamuri S, Siddesha J, et al. Cardiac-restricted Overexpression of TRAF3 Interacting Protein 2 (TRAF3IP2) Results in Spontaneous Development of Myocardial Hypertrophy, Fibrosis, and Dysfunction. J Biol Chem. 2016;291:19425-36 pubmed publisher
    b>TRAF3IP2 (TRAF3 interacting protein 2; previously known as CIKS or Act1) is a key intermediate in the normal inflammatory response and the pathogenesis of various autoimmune and inflammatory diseases...
  52. Sun H, Zhong D, Jin J, Liu Q, Wang H, Li G. Upregulation of miR-215 exerts neuroprotection effects against ischemic injury via negative regulation of Act1/IL-17RA signaling. Neurosci Lett. 2018;662:233-241 pubmed publisher
    ..The relationship between miR-215 and interleukin (IL)-17 was evaluated in human peripheral blood from 29 patients. Act1 was upregulated whereas miR-215 was downregulated in ischemic stroke...
  53. Leonardi A, Chariot A, Claudio E, Cunningham K, Siebenlist U. CIKS, a connection to Ikappa B kinase and stress-activated protein kinase. Proc Natl Acad Sci U S A. 2000;97:10494-9 pubmed
    ..Here we describe the molecular cloning of CIKS (connection to IKK and SAPK/JNK), a previously unknown protein that directly interacts with NEMO/IKKgamma in cells...
  54. Heo Y, Oh H, Jung Y, Cho M, Lee S, Yu J, et al. The expression of the receptor for advanced glycation end-products (RAGE) in RA-FLS is induced by IL-17 via Act-1. Arthritis Res Ther. 2011;13:R113 pubmed publisher
    ..The role of nuclear factor-?B (NF-?B) activator 1 (Act1) in IL-17-induced RAGE expression in RA-FLS was also evaluated...
  55. Somanna N, Yariswamy M, Garagliano J, Siebenlist U, Mummidi S, Valente A, et al. Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2. Cell Signal. 2015;27:1928-38 pubmed publisher
    ..Here we have investigated whether Aldo-mediated cardiomycocyte hypertrophy is dependent on TRAF3IP2, an upstream regulator of IKK and JNK...
  56. Mwamburi M, Liebler E, Tenaglia A. Review of non-invasive vagus nerve stimulation (gammaCore): efficacy, safety, potential impact on comorbidities, and economic burden for episodic and chronic cluster headache. Am J Manag Care. 2017;23:S317-S325 pubmed
    ..The ACute Treatment of Cluster Headache Studies (ACT1 and ACT2), both double-blind sham-controlled randomized trials, did not meet the primary endpoints of the trials ..
  57. Ciccacci C, Rufini S, Mancinelli S, Buonomo E, Giardina E, Scarcella P, et al. A pharmacogenetics study in Mozambican patients treated with nevirapine: full resequencing of TRAF3IP2 gene shows a novel association with SJS/TEN susceptibility. Int J Mol Sci. 2015;16:5830-8 pubmed publisher
    ..In the last years TRAF3IP2 gene variants had been described as associated with susceptibility to several diseases such as psoriasis and ..
  58. Velichko S, Zhou X, Zhu L, Anderson J, Wu R, Chen Y. A Novel Nuclear Function for the Interleukin-17 Signaling Adaptor Protein Act1. PLoS ONE. 2016;11:e0163323 pubmed publisher
    ..The intracellular molecule Act1 has been demonstrated to be an essential mediator of IL-17A signaling...
  59. Conigliaro P, Ciccacci C, Politi C, Triggianese P, Rufini S, Kroegler B, et al. Polymorphisms in STAT4, PTPN2, PSORS1C1 and TRAF3IP2 Genes Are Associated with the Response to TNF Inhibitors in Patients with Rheumatoid Arthritis. PLoS ONE. 2017;12:e0169956 pubmed publisher
    ..We aimed at exploring 4 SNPs in candidate genes (STAT4, PTPN2, PSORS1C1 and TRAF3IP2) in order to investigate their potential role in the response to therapy with tumor necrosis factor inhibitors (..
  60. Morelli C, Magnanini C, Mungall A, Negrini M, Barbanti Brodano G. Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia. Gene. 2000;252:217-25 pubmed
    Two new genes were cloned from region 6q21 and characterized. One gene, C6orf4-6, expresses three mRNA isoforms diverging at the 5' and 3' ends, and encodes two protein isoforms that differ by nine amino acids at their amino terminus...
  61. Ciccacci C, Biancone L, Di Fusco D, Ranieri M, Condino G, Giardina E, et al. TRAF3IP2 gene is associated with cutaneous extraintestinal manifestations in inflammatory bowel disease. J Crohns Colitis. 2013;7:44-52 pubmed publisher
    Genome-wide association (GWA) studies recently identified a novel gene, TRAF3IP2, involved in the susceptibility to psoriasis. Common immune-mediated mechanisms involving the skin or the gut have been suggested...
  62. Lv F, Song L, Wang X, Qiu F, Li X. The role of Act1, a NF-?B-activating protein, in IL-6 and IL-8 levels induced by IL-17 stimulation in SW982 cells. Pharm Biol. 2013;51:1444-50 pubmed publisher
    ..RNA (siRNA) oligonucleotides were designed and obtained according to the GenBank cDNA, the sequence of Act1 (Traf3ip2)...
  63. Wu L, Wang C, Boisson B, Misra S, Rayman P, Finke J, et al. The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling. J Immunol. 2014;193:1590-9 pubmed publisher
    IL-17 is a proinflammatory cytokine implicated in the pathogenesis of autoimmune diseases including psoriasis. ACT1 is an essential adaptor molecule in the IL-17 signaling pathway...
  64. Wyant T, Estevam J, Yang L, Rosario M. Development and validation of receptor occupancy pharmacodynamic assays used in the clinical development of the monoclonal antibody vedolizumab. Cytometry B Clin Cytom. 2016;90:168-76 pubmed publisher
    ..The results of these assays demonstrated the practical use of flow cytometry to examine pharmacodynamic response in clinical trials. ..
  65. Qiu A, Bian Z, Mao P, Liu Q. IL-17A exacerbates diabetic retinopathy by impairing Müller cell function via Act1 signaling. Exp Mol Med. 2016;48:e280 pubmed publisher
    ..In both the HG-treated Müller cells and Akita mouse retina, the Act1/TRAF6/IKK/NF-κB signaling pathway was activated...
  66. Ren J, Gwin W, Zhou X, Wang X, Huang H, Jiang N, et al. Adaptive T cell responses induced by oncolytic Herpes Simplex Virus-granulocyte macrophage-colony-stimulating factor therapy expanded by dendritic cell and cytokine-induced killer cell adoptive therapy. Oncoimmunology. 2017;6:e1264563 pubmed publisher
    ..Five of the OVT treated patients underwent leukapheresis, generation, and delivery of DC-CIKs, and two had SD, whereas three progressed...
  67. Qu F, Gao H, Zhu S, Shi P, Zhang Y, Liu Y, et al. TRAF6-dependent Act1 phosphorylation by the I?B kinase-related kinases suppresses interleukin-17-induced NF-?B activation. Mol Cell Biol. 2012;32:3925-37 pubmed publisher
    ..IL-17 receptor (IL-17R)-proximal signaling complex (IL-17R-Act1-TRAF6) is essential for IL-17-mediated NF-?B activation, while IL-17-mediated mRNA stability is TRAF6 independent...
  68. Boisson B, Wang C, Pedergnana V, Wu L, Cypowyj S, Rybojad M, et al. An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis. Immunity. 2013;39:676-86 pubmed publisher
    ..We report a biallelic missense mutation (T536I) in the adaptor molecule ACT1 in two siblings with CMC...
  69. Lambert S, Swindell W, Tsoi L, Stoll S, Elder J. Dual Role of Act1 in Keratinocyte Differentiation and Host Defense: TRAF3IP2 Silencing Alters Keratinocyte Differentiation and Inhibits IL-17 Responses. J Invest Dermatol. 2017;137:1501-1511 pubmed publisher
    b>TRAF3IP2 is a candidate psoriasis susceptibility gene encoding Act1, an adaptor protein with ubiquitin ligase activity that couples the IL-17 receptor to downstream signaling pathways...
  70. Maselko M, Heinsch S, Chacón J, Harcombe W, Smanski M. Engineering species-like barriers to sexual reproduction. Nat Commun. 2017;8:883 pubmed publisher
    ..As a proof of concept, we target the ACT1 promoter of the model organism Saccharomyces cerevisiae using a dCas9-based transcriptional activator...
  71. Shi P, Zhu S, Lin Y, Liu Y, Liu Y, Chen Z, et al. Persistent stimulation with interleukin-17 desensitizes cells through SCF?-TrCP-mediated degradation of Act1. Sci Signal. 2011;4:ra73 pubmed publisher
    ..To avoid persistent inflammation, signaling by the IL-17 receptor (IL-17R), which involves the adaptor protein Act1, must be tightly controlled...
  72. Debniak T, Soczawa E, Boer M, Różewicka Czabańska M, Wisniewska J, Serrano Fernandez P, et al. Common variants of ZNF750, RPTOR and TRAF3IP2 genes and psoriasis risk. Arch Dermatol Res. 2014;306:231-8 pubmed publisher
    ..Minor alleles of all four TRAF3IP2 variants were more frequent among cases...
  73. Wu N, Huang D, Tsou H, Lin Y, Lin W. Syk mediates IL-17-induced CCL20 expression by targeting Act1-dependent K63-linked ubiquitination of TRAF6. J Invest Dermatol. 2015;135:490-498 pubmed publisher
    ..Immunoprecipitation also indicated the interaction of Syk with signal molecules of IL-17R, such as TRAF6 and Act1, under IL-17A stimulation...
  74. Wan Q, Zhou Z, Ding S, He J. The miR-30a Negatively Regulates IL-17-Mediated Signal Transduction by Targeting Traf3ip2. J Interferon Cytokine Res. 2015;35:917-23 pubmed publisher
    ..These suppressive effects of miR-30a were mediated by directly targeting Traf3ip2 mRNA (coding for Act1)...
  75. Urabe S, Isomoto H, Ishida T, Maeda K, Inamine T, Kondo S, et al. Genetic Polymorphisms of IL-17F and TRAF3IP2 Could Be Predictive Factors of the Long-Term Effect of Infliximab against Crohn's Disease. Biomed Res Int. 2015;2015:416838 pubmed publisher
    ..penetrating disease, a G/G genotype of rs766748 in IL-17F, and a C/C or C/A genotype of rs1883136 in TRAF3IP2, independently contributed to response to IFX after 1 year of treatment...
  76. Padilla J, Carpenter A, Das N, Kandikattu H, López Ongil S, Martinez Lemus L, et al. TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells. Am J Physiol Heart Circ Physiol. 2018;314:H52-H64 pubmed publisher
    ..Here, we show that adapter molecule TRAF3 interacting protein 2 (TRAF3IP2) mediates high glucose-induced ET-1 production in endothelial cells and ET-1-mediated endothelial cell ..
  77. Mauro C, Vito P, Mellone S, Pacifico F, Chariot A, Formisano S, et al. Role of the adaptor protein CIKS in the activation of the IKK complex. Biochem Biophys Res Commun. 2003;309:84-90 pubmed
    ..We have previously identified a novel gene, named CIKS (connection to IkappaB-kinase and SAPK), able to bind the regulatory sub-unit NEMO/IKKgamma and to activate NF-..
  78. Ryzhakov G, Blazek K, Lai C, Udalova I. IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling. J Immunol. 2012;189:4852-8 pubmed publisher
    ..In this study, we show that the IL-17R adaptor protein Act1/CIKS is involved in this process...
  79. Kijima S, Hirose K, Kong S, Wada M, Uyeda T. Distinct Biochemical Properties of Arabidopsis thaliana Actin Isoforms. Plant Cell Physiol. 2016;57:46-56 pubmed publisher
    ..actin isoforms, two major vegetative actin isoforms, ACT2 and ACT7, and two major reproductive isoforms, ACT1 and ACT11, and characterized them biochemically...
  80. Govind N, Choudhury A, Hodkinson B, Ickinger C, Frost J, Lee A, et al. Immunochip identifies novel, and replicates known, genetic risk loci for rheumatoid arthritis in black South Africans. Mol Med. 2014;20:341-9 pubmed publisher
    ..polymorphisms (SNPs) in the intergenic regions LOC389203|RBPJ, LOC100131131|IL1R1, KIAA1919|REV3L, LOC643749|TRAF3IP2, and SNPs in the intron and untranslated regions (UTR) of IRF1 and the intronic region of ICOS and KIAA1542 ..
  81. Tomuschat C, O Donnell A, Coyle D, Puri P. Increased Act1/IL-17R expression in Hirschsprung's disease. Pediatr Surg Int. 2016;32:1201-1207 pubmed
    ..b>Act1 is an essential adaptor molecule required for the IL-17-mediated inflammatory responses via interaction with IL-17 ..
  82. Pospich S, Kumpula E, von der Ecken J, Vahokoski J, Kursula I, Raunser S. Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability. Proc Natl Acad Sci U S A. 2017;114:10636-10641 pubmed publisher
    ..In contrast to canonical actin, P. falciparum actin 1 (PfAct1) does not readily polymerize into long, stable filaments...
  83. Ehm M, Aponte J, Chiano M, Yerges Armstrong L, Johnson T, Barker J, et al. Phenome-wide association study using research participants' self-reported data provides insight into the Th17 and IL-17 pathway. PLoS ONE. 2017;12:e0186405 pubmed publisher
    ..Arg381Gln in IL23R with a decrease in dandruff frequency, the variant encoding p.Asp10Asn in TRAF3IP2 with risk of male-pattern balding, and the RORC regulatory variant (rs4845604) with protection from allergies...
  84. Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U. Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. J Biol Chem. 2002;277:37029-36 pubmed
    ..These results indicate that TANK can synergize with IKK epsilon or TBK1 to link them to IKK complexes, where the two kinases may modulate aspects of NF-kappa B activation. ..
  85. Qian Y, Qin J, Cui G, Naramura M, Snow E, Ware C, et al. Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity. 2004;21:575-87 pubmed
    ..Genetic deficiency in a novel adaptor molecule, Act1, for CD40 and BAFF results in a dramatic increase in peripheral B cells, which culminates in lymphadenopathy and ..
  86. Liu L, Yang M, Zhou M, Li J, Liu B, Pan Y. Improvement of cytotoxicity of autologous CIKs from patients with breast cancer to MCF-7 cells by suppressed PD-1 expression. Cancer Biomark. 2017;20:609-615 pubmed publisher
    To investigate the improvement of cytotoxicity of autologous CIKs from patients with breast cancer to MCF-7 cells by suppressed PD-1 expression.
  87. Cao J, Chen C, Gao Y, Hu L, Liang Y, Xiao J. Identification of a protein associated with the activity of cytokine-induced killer cells. Oncol Lett. 2017;14:6937-6942 pubmed publisher
    Cytokine-induced killer cells (CIKs) adoptive immunotherapy for efficient antitumor ability is used clinically, but details regarding the proteins associated with CIK activity remain unclear...
  88. Fan X, Wang P, Zhang C, Zhang Y, Fu Y, Zhang C, et al. All-trans retinoic acid enhances cytotoxicity of CIK cells against human lung adenocarcinoma by upregulating MICA and IL-2 secretion. Sci Rep. 2017;7:16481 pubmed publisher
    To determine the growth inhibition capability of all-trans retinoic acid (ATRA) with cytokine-induced killer cells (CIKs), we evaluated their effects, alone and in combination, on human lung carcinoma A549 cells...
  89. Hayashi M, Hirota T, Saeki H, Nakagawa H, Ishiuji Y, Matsuzaki H, et al. Genetic polymorphism in the TRAF3IP2 gene is associated with psoriasis vulgaris in a Japanese population. J Dermatol Sci. 2014;73:264-5 pubmed publisher
  90. Qin L, Wang X, Zhang S, Feng S, Yin L, Zhou H. Lipopolysaccharide-induced autophagy participates in the control of pro-inflammatory cytokine release in grass carp head kidney leukocytes. Fish Shellfish Immunol. 2016;59:389-397 pubmed publisher
    ..Accordingly, grass carp kidney cells (CIKs) with stable expression of GFP-gcLC3B were established and GFP-gcLC3B puncta were counted under a confocal ..
  91. Liu C, Qian W, Qian Y, Giltiay N, Lu Y, Swaidani S, et al. Act1, a U-box E3 ubiquitin ligase for IL-17 signaling. Sci Signal. 2009;2:ra63 pubmed publisher
    ..b>Act1 is an essential adaptor molecule in IL-17-mediated signaling and is recruited to the IL-17 receptor (IL-17R) upon ..
  92. Valente A, Irimpen A, Siebenlist U, Chandrasekar B. OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators. Free Radic Biol Med. 2014;70:117-28 pubmed publisher
    ..b>TRAF3IP2 is a redox-sensitive cytoplasmic adapter protein and an upstream regulator of IKK/NF-κB and JNK/AP-1...