Gene Symbol: TRAF3
Description: TNF receptor associated factor 3
Alias: CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, RNF118, TNF receptor-associated factor 3, CD40 associated protein 1, CD40 binding protein, CD40 receptor associated factor 1, LMP1-associated protein 1, RING-type E3 ubiquitin transferase TRAF3
Species: human
Products:     TRAF3

Top Publications

  1. Liao G, Zhang M, Harhaj E, Sun S. Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. J Biol Chem. 2004;279:26243-50 pubmed
    ..of NIK regulation is through its dynamic interaction with the tumor necrosis factor receptor-associated factor 3 (TRAF3)...
  2. Besse A, Campos A, Webster W, Darnay B. TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase. Biochem Biophys Res Commun. 2007;359:660-4 pubmed
    ..Interestingly, TRIP expression was down regulated during the late stages of osteoclastogenesis. Taken together, our results demonstrate that TRIP is a novel RING-dependent Ub ligase and a binding partner for TRAFs. ..
  3. Li C, Ni C, Havert M, Cabezas E, He J, Kaiser D, et al. Downstream regulator TANK binds to the CD40 recognition site on TRAF3. Structure. 2002;10:403-11 pubmed
    ..The crystal structure of a region of TANK bound to TRAF3 has been determined and compared to a similar CD40/TRAF3 complex. TANK and CD40 bind to the same crevice on TRAF3...
  4. Gao L, Coope H, Grant S, Ma A, Ley S, Harhaj E. ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling. J Biol Chem. 2011;286:36592-602 pubmed publisher
    ..ABIN1 and TAX1BP1 together disrupted the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKKi to attenuate lysine 63-linked polyubiquitination of TBK1/IKKi...
  5. Wu S, Xie P, Welsh K, Li C, Ni C, Zhu X, et al. LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3. J Biol Chem. 2005;280:33620-6 pubmed
    ..TRAFs are intracellular co-inducers of downstream signaling from CD40 and other TNFRs, and TRAF3 is required for activation of B lymphocytes by LMP1...
  6. Qian Y, Qin J, Cui G, Naramura M, Snow E, Ware C, et al. Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity. 2004;21:575-87 pubmed
    ..These findings demonstrate that Act1 plays an important role in the homeostasis of B cells by attenuating CD40 and BAFFR signaling. ..
  7. Bista P, Zeng W, Ryan S, Bailly V, Browning J, Lukashev M. TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor. J Biol Chem. 2010;285:12971-8 pubmed publisher
    Components of lymphotoxin beta receptor (LTBR)-associated signaling complexes, including TRAF2, TRAF3, NIK, IKK1, and IKK2 have been shown to participate in the coupling of LTBR to NFkappaB...
  8. Gatot J, Gioia R, Chau T, Patrascu F, Warnier M, Close P, et al. Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF. J Biol Chem. 2007;282:31131-46 pubmed
    ..IKKepsilon-mediated IRF3/7 phosphorylations through some Toll-like receptor-dependent pathways and is part of a TRAF3-containing complex...
  9. Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell. 1995;80:389-99 pubmed
    ..growth transformation and is now shown to interact with a novel human protein (LMP1-associated protein 1 [LAP1])...

More Information


  1. Mao A, Li S, Zhong B, Li Y, Yan J, Li Q, et al. Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response. J Biol Chem. 2010;285:9470-6 pubmed publisher
    ..coimmunoprecipitation experiments indicated that viral infection caused recruitment of cIAP1 and cIAP2 to TRAF3, TRAF6, and VISA...
  2. Arch R, Thompson C. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. Mol Cell Biol. 1998;18:558-65 pubmed
    ..While 4-1BB bound TRAF2 and TRAF1, Ox40 interacted with TRAF3 and TRAF2...
  3. Hu H, O Rourke K, Boguski M, Dixit V. A novel RING finger protein interacts with the cytoplasmic domain of CD40. J Biol Chem. 1994;269:30069-72 pubmed
    ..This is the first identification of a molecule that interacts with CD40 and whose sequence suggests a potential role in signaling. ..
  4. Saha S, Cheng G. TRAF3: a new regulator of type I interferons. Cell Cycle. 2006;5:804-7 pubmed
    ..Interestingly, all of the major viral recognition pathways characterized thus far require TRAF3 to initiate type I interferon production...
  5. Oganesyan G, Saha S, Guo B, He J, Shahangian A, Zarnegar B, et al. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature. 2006;439:208-11 pubmed
    ..Here we demonstrate that cells lacking TRAF3, a member of the TNF receptor-associated factor family, are defective in type I IFN responses activated by several ..
  6. Hildebrand J, Yi Z, Buchta C, Poovassery J, Stunz L, Bishop G. Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions. Immunol Rev. 2011;244:55-74 pubmed publisher
    ..In recent years, there has been a resurgence of interest and exploration of the roles played by TRAF3 and TRAF5 in cellular regulation, particularly in cells of the immune system, the cell types of focus in this ..
  7. Ni C, Oganesyan G, Welsh K, Zhu X, Reed J, Satterthwait A, et al. Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation. J Immunol. 2004;173:7394-400 pubmed
    ..However, BAFF-R binds only one TRAF adaptor, TRAF3, and this interaction negatively regulates activation of NF-kappaB...
  8. Keats J, Fonseca R, Chesi M, Schop R, Baker A, Chng W, et al. Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell. 2007;12:131-44 pubmed
    ..We report mutations in ten genes causing the inactivation of TRAF2, TRAF3, CYLD, cIAP1/cIAP2 and activation of NFKB1, NFKB2, CD40, LTBR, TACI, and NIK that result primarily in constitutive ..
  9. Cheng G, Cleary A, Ye Z, Hong D, Lederman S, Baltimore D. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. 1995;267:1494-8 pubmed
    ..A yeast two-hybrid screen identified a gene, CRAF1, encoding a protein that interacts directly with the CD40 cytoplasmic tail through a region of similarity to the ..
  10. Hauer J, Püschner S, Ramakrishnan P, Simon U, Bongers M, Federle C, et al. TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. Proc Natl Acad Sci U S A. 2005;102:2874-9 pubmed
    ..Via TRAF2/5, CD40 activates both the canonical and the noncanonical NF-kappaB pathways. We observed that TRAF3 specifically blocked the NF-kappaB activation via TRAF2/5...
  11. Hsu H, Huang J, Shu H, Baichwal V, Goeddel D. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity. 1996;4:387-96 pubmed
    ..These results suggest that distinct domains of RIP participate in the TNF signaling cascades leading to apoptosis and NF-kappa B activation. ..
  12. Nakano H, Oshima H, Chung W, Williams Abbott L, Ware C, Yagita H, et al. TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. J Biol Chem. 1996;271:14661-4 pubmed
    ..These results show TRAF5 is functionally similar to TRAF2 in that both mediate activation NF-kappaB and implicate TRAF5 as a signal transducer for LT-betaR. ..
  13. VanArsdale T, VanArsdale S, Force W, Walter B, Mosialos G, Kieff E, et al. Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB. Proc Natl Acad Sci U S A. 1997;94:2460-5 pubmed
    ..with LT alpha1 beta2 or agonistic LTbeta R antibodies causes rapid recruitment of TNFR-associated factor 3 (TRAF3) to the LTbeta R cytoplasmic domain...
  14. Hacker H, Tseng P, Karin M. Expanding TRAF function: TRAF3 as a tri-faced immune regulator. Nat Rev Immunol. 2011;11:457-68 pubmed publisher
    ..The function of one TRAF in particular, TRAF3, remained elusive for many years...
  15. Bradley J, Pober J. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene. 2001;20:6482-91 pubmed
    ..TRAF proteins are expressed in normal and diseased tissue in a regulated fashion, suggesting that they play an important role in physiological and pathological processes. ..
  16. Ng M, Ho T, Kok K, Siu K, Li J, Jin D. MIP-T3 is a negative regulator of innate type I IFN response. J Immunol. 2011;187:6473-82 pubmed publisher
    ..MIP-T3 interacts specifically with TRAF3, but its function in innate IFN response remains unclear...
  17. Ni C, Welsh K, Leo E, Chiou C, Wu H, Reed J, et al. Molecular basis for CD40 signaling mediated by TRAF3. Proc Natl Acad Sci U S A. 2000;97:10395-9 pubmed
    ..crystal structure of a 20-residue fragment from the cytoplasmic domain of CD40 in complex with the TRAF domain of TRAF3. The CD40 fragment binds as a hairpin loop across the surface of the TRAF domain...
  18. Nakhaei P, Mesplede T, Solis M, Sun Q, Zhao T, Yang L, et al. The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation. PLoS Pathog. 2009;5:e1000650 pubmed publisher
    ..through Lys48-linked, ubiquitin-mediated degradation of the tumor necrosis factor receptor-associated factor 3 (TRAF3) adapter...
  19. van Eyndhoven W, Frank D, Kalachikov S, Cleary A, Hong D, Cho E, et al. A single gene for human TRAF-3 at chromosome 14q32.3 encodes a variety of mRNA species by alternative polyadenylation, mRNA splicing and transcription initiation. Mol Immunol. 1998;35:1189-206 pubmed
    ..Together, these data indicate that a single TRAF-3 gene encodes a variety of mRNA species by a combination of alternative polyadenylation, alternative mRNA splicing and/or alternative initiation. ..
  20. Pullen S, Miller H, Everdeen D, Dang T, Crute J, Kehry M. CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. Biochemistry. 1998;37:11836-45 pubmed
    ..TRAF1, TRAF2, TRAF3, and TRAF6, but not TRAF4 or TRAF5, bound directly to the CD40 cytoplasmic domain...
  21. Tang E, Wang C. TRAF5 is a downstream target of MAVS in antiviral innate immune signaling. PLoS ONE. 2010;5:e9172 pubmed publisher
    ..MAVS dimerization in response to viral RNA, allowing the CARD to bind to and activate the downstream effector TRAF3. Notably, dimerization of the MAVS CARD alone is sufficient to activate IRF3, IRF7, and NF-kappaB...
  22. Li S, Zheng H, Mao A, Zhong B, Li Y, Liu Y, et al. Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. J Biol Chem. 2010;285:4291-7 pubmed publisher
    ..Coimmunoprecipitations indicated OTUB1 and -2 interacted with TRAF3 and TRAF6, two E3 ubiquitin ligases required for virus-triggered IRF3 and NF-kappaB activation, respectively...
  23. Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, et al. CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase. J Biol Chem. 1998;273:13353-8 pubmed
    ..These results indicate that TRAF2 and TRAF5 are involved in NF-kappaB and SAPK/JNK activation by CD27, and NIK is a common downstream kinase of TRAF2 and TRAF5 for NF-kappaB and SAPK/JNK activation. ..
  24. Wu L, Nakano H, Wu Z. The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kappaB through TRAF6 and TAK1. J Biol Chem. 2006;281:2162-9 pubmed
    ..Although the CTAR1-mediated NF-kappaB activation was previously shown to be TRAF3-dependent, we showed here that the CTAR2-mediated NF-kappaB activation is mainly TRAF6-dependent but TRAF2/5-..
  25. Ling L, Goeddel D. MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network. J Biol Chem. 2000;275:23852-60 pubmed
    In this study, we report the identification of a novel tumor necrosis factor receptor-associated factor 3 (TRAF3)-interacting protein designated MIP-T3. MIP-T3 is a 83-kDa protein with no significant homology to known mammalian proteins...
  26. Karim R, Tummers B, Meyers C, Biryukov J, Alam S, Backendorf C, et al. Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response. PLoS Pathog. 2013;9:e1003384 pubmed publisher
    ..UCHL1 accomplished this by inhibiting tumor necrosis factor receptor-associated factor 3 (TRAF3) K63 poly-ubiquitination which lead to lower levels of TRAF3 bound to TANK-binding kinase 1 and a reduced ..
  27. Mainou B, Everly D, Raab Traub N. Unique signaling properties of CTAR1 in LMP1-mediated transformation. J Virol. 2007;81:9680-92 pubmed
    ..Dominant-negative forms of TRAF2 and TRAF3 inhibited but did not fully block LMP1-mediated transformation...
  28. Mankouri J, Fragkoudis R, Richards K, Wetherill L, Harris M, Kohl A, et al. Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection. PLoS Pathog. 2010;6:e1000778 pubmed publisher
    ..identified optineurin in a protein complex containing the antiviral protein kinase TBK1 and the ubiquitin ligase TRAF3. Furthermore, mutagenesis studies determined that binding of ubiquitin was essential for both the correct sub-..
  29. Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O Rourke K, et al. DUBA: a deubiquitinase that regulates type I interferon production. Science. 2007;318:1628-32 pubmed
    ..DUBA bound tumor necrosis factor receptor-associated factor 3 (TRAF3), an adaptor protein essential for the IFN-I response...
  30. Alff P, Sen N, Gorbunova E, Gavrilovskaya I, Mackow E. The NY-1 hantavirus Gn cytoplasmic tail coprecipitates TRAF3 and inhibits cellular interferon responses by disrupting TBK1-TRAF3 complex formation. J Virol. 2008;82:9115-22 pubmed publisher
    ..The formation of TBK1-TRAF3 complexes directs IRF-3 phosphorylation, and both IRF-3 and NF-kappaB activation are required for transcription ..
  31. Davies C, Mak T, Young L, Eliopoulos A. TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells. Mol Cell Biol. 2005;25:9806-19 pubmed
    ..These observations provide novel insight into the mechanisms of CD40 signaling and the multiple roles played by TRAF6 in signal transduction. ..
  32. He L, Grammer A, Wu X, Lipsky P. TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation. J Biol Chem. 2004;279:55855-65 pubmed
    ..homotypic association of TRAF2, -3, and -5 was observed, as well as heterotypic association of TRAF1-TRAF2 and TRAF3-TRAF5...
  33. Li C, Norris P, Ni C, Havert M, Chiong E, Tran B, et al. Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling. J Biol Chem. 2003;278:50523-9 pubmed
    ..In this study, the crystal structure of a region of the cytoplasmic domain of LTbetaR bound to TRAF3 has revealed an unexpected new recognition motif, 388IPEEGD393, for TRAF3 binding...
  34. Xie P, Kraus Z, Stunz L, Liu Y, Bishop G. TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signaling. J Immunol. 2011;186:143-55 pubmed publisher
    ..However, the specific function of TRAF3 in T cells has remained unclear...
  35. Hatzoglou A, Roussel J, Bourgeade M, Rogier E, Madry C, Inoue J, et al. TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. J Immunol. 2000;165:1322-30 pubmed
    ..performed in transfected cells showed that BCMA associates with TNFR-associated factor (TRAF) 1, TRAF2, and TRAF3 adaptor proteins...
  36. van Zuylen W, Doyon P, Clément J, Khan K, D Ambrosio L, Dô F, et al. Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity. PLoS Pathog. 2012;8:e1002747 pubmed publisher
    Tumor Necrosis Factor receptor-associated factor-3 (TRAF3) is a central mediator important for inducing type I interferon (IFN) production in response to intracellular double-stranded RNA (dsRNA)...
  37. Song H, Regnier C, Kirschning C, Goeddel D, Rothe M. Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc Natl Acad Sci U S A. 1997;94:9792-6 pubmed
    ..Thus, TRAF2 is the bifurcation point of two kinase cascades leading to activation of NF-kappaB and JNK, respectively. ..
  38. Hu H, Brittain G, Chang J, Puebla Osorio N, Jin J, Zal A, et al. OTUD7B controls non-canonical NF-?B activation through deubiquitination of TRAF3. Nature. 2013;494:371-4 pubmed publisher
    ..the non-canonical NF-?B pathway involves degradation of an inhibitory protein, TNF receptor-associated factor 3 (TRAF3), but how this signalling event is controlled is still unknown...
  39. Pérez de Diego R, Sancho Shimizu V, Lorenzo L, Puel A, Plancoulaine S, Picard C, et al. Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis. Immunity. 2010;33:400-11 pubmed publisher
    Tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) functions downstream of multiple TNF receptors and receptors that induce interferon-? (IFN-?), IFN-?, and IFN-? production, including Toll-like receptor 3 (TLR3), which is ..
  40. Saha S, Pietras E, He J, Kang J, Liu S, Oganesyan G, et al. Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J. 2006;25:3257-63 pubmed
    ..Here, we demonstrate that TRAF3, like Cardif, is required for type I interferon production in response to intracellular double-stranded RNA...
  41. Kuai J, Nickbarg E, Wooters J, Qiu Y, Wang J, Lin L. Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis. J Biol Chem. 2003;278:14363-9 pubmed
    ..Four of five proteins identified, TRAF2, TRAF3, cIAP1, and Smac, are reported here...
  42. Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J. Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40. Proc Natl Acad Sci U S A. 1999;96:1234-9 pubmed
    ..Although four members of the tumor necrosis factor receptor-associated factor (TRAF) family, including TRAF2, TRAF3, TRAF5, and TRAF6, bind to the CD40 cyt, how each TRAF protein contributes to the NFkappaB activation by CD40 is ..
  43. Krajewski S, Zapata J, Krajewska M, VanArsdale T, Shabaik A, Gascoyne R, et al. Immunohistochemical analysis of in vivo patterns of TRAF-3 expression, a member of the TNF receptor-associated factor family. J Immunol. 1997;159:5841-52 pubmed
    ..The findings establish for the first time the cell type- and differentiation-specific patterns of expression of a member of the TRAF family of proteins. ..
  44. Miliara S, Gkouskou K, Sharp T, Eliopoulos A. SUMOylation is required for optimal TRAF3 signaling capacity. PLoS ONE. 2013;8:e80470 pubmed publisher
    ..Here, we report that TRAF3, a TRAF family member with a key role in Toll-like and TNF family receptor signaling and suppressor of ..
  45. Hansberg Pastor V, González Arenas A, Camacho Arroyo I. CCAAT/enhancer binding protein ? negatively regulates progesterone receptor expression in human glioblastoma cells. Mol Cell Endocrinol. 2017;439:317-327 pubmed publisher
    ..PR-B expression regulation in glioblastoma cell lines, which expressed different ratios of PR and C/EBP? isoforms (LAP1, LAP2, and LIP)...
  46. Li S, Wang C, Jou Y, Huang S, Hsiao L, Wan L, et al. SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6. Int J Mol Sci. 2016;17: pubmed publisher
    ..and anti-Lys63 ubiquitin antibodies indicated the SARS-CoV PLPro removed Lys63-linked ubiquitin chains of TRAF3 and TRAF6, but not Lys48-linked ubiquitin chains in un-treated and treated cells...
  47. Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed publisher
    ..Here we show that tumour necrosis factor receptor-associated factor 3 (TRAF3) is upregulated in mouse and human livers with hepatic steatosis...
  48. Shinzawa M, Konno H, Qin J, Akiyama N, Miyauchi M, Ohashi H, et al. Catalytic subunits of the phosphatase calcineurin interact with NF-κB-inducing kinase (NIK) and attenuate NIK-dependent gene expression. Sci Rep. 2015;5:10758 pubmed publisher
    ..Intriguingly, we found that TRAF3, a critical regulator of NIK activity, also binds to CnAα and CnAβ...
  49. Sandberg M, Hammerschmidt W, Sugden B. Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3. J Virol. 1997;71:4649-56 pubmed
    ..We have characterized and mapped in detail a region of LMP-1 that associates with TRAF1, TRAF2, and TRAF3. TRAF3 alone associates with LMP-1 in a yeast two-hybrid assay, whereas all three TRAF molecules associate with ..
  50. Jang I, Lee Z, Kim Y, Kim S, Kwon B. Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B. Biochem Biophys Res Commun. 1998;242:613-20 pubmed
    ..We found that tumor necrosis factor receptor-associated factor (TRAF) 1, TRAF2, and TRAF3, all interacted with the cytoplasmic domain of 4-1BB...
  51. Lee Z, Lee S, Kwack K, Yeo W, Lee T, Bae S, et al. Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells. J Leukoc Biol. 2001;69:490-6 pubmed
    ..In this study, we demonstrate that TRAF3 is proteolyzed during cell death in a caspase-dependent manner...
  52. Peng S, Wang K, Gu Y, Nan X, Xing J, Cui Q, et al. TRAF3IP3, a novel autophagy up-regulated gene, is involved in marginal zone B lymphocyte development and survival. Clin Exp Immunol. 2015;182:57-68 pubmed publisher
    Tumour necrosis factor receptor-associated factor 3 (TRAF3) interacting protein 3 (TRAF3IP3; also known as T3JAM) is expressed specifically in immune organs and tissues...
  53. Jiang X, Deng K, Luo Y, Jiang D, Gao L, Zhang X, et al. Tumor necrosis factor receptor-associated factor 3 is a positive regulator of pathological cardiac hypertrophy. Hypertension. 2015;66:356-67 pubmed publisher
    ..Here, we identified tumor necrosis factor receptor-associated factor 3 (TRAF3), an adaptor protein in tumor necrosis factor-related signaling cascades, as a key regulator of cardiac ..
  54. Chen X, Yang X, Zheng Y, Yang Y, Xing Y, Chen Z. SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex. Protein Cell. 2014;5:369-81 pubmed publisher
    ..Meanwhile, we showed that PLpro-TM physically interacts with TRAF3, TBK1, IKK?, STING, and IRF3, the key components that assemble the STING-TRAF3-TBK1 complex for activation of IFN ..
  55. Werneburg B, Zoog S, Dang T, Kehry M, Crute J. Molecular characterization of CD40 signaling intermediates. J Biol Chem. 2001;276:43334-42 pubmed
    ..Transiently expressed soluble trimeric CD40 cytoplasmic domain was isolated as complexes that contained TRAF2, TRAF3, TRAF5, TRAF6, and the inhibitor of apoptosis protein (c-IAP1)...
  56. Guven Maiorov E, Keskin O, Gursoy A, VanWaes C, Chen Z, Tsai C, et al. TRAF3 signaling: Competitive binding and evolvability of adaptive viral molecular mimicry. Biochim Biophys Acta. 2016;1860:2646-55 pubmed publisher
    The tumor necrosis factor receptor (TNFR) associated factor 3 (TRAF3) is a key node in innate and adaptive immune signaling pathways...
  57. Jiang Z, Mak T, Sen G, Li X. Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci U S A. 2004;101:3533-8 pubmed
    ..Therefore, double-stranded RNA-induced TLR3/TRIF-mediated NF-kappaB and IRF3 activation diverge at TRIF. ..
  58. de Jong S, Albrecht J, Giehler F, Kieser A, Sticht H, Biesinger B. Noncanonical NF-?B activation by the oncoprotein Tio occurs through a nonconserved TRAF3-binding motif. Sci Signal. 2013;6:ra27 pubmed publisher
    ..depends on a distinct sequence motif that directly recruits tumor necrosis factor receptor-associated factor 3 (TRAF3)...
  59. Hsu H, Shu H, Pan M, Goeddel D. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 1996;84:299-308 pubmed
    ..Thus, these two TNFR1-TRADD signaling cascades appear to bifurcate at TRADD. ..
  60. Zhao K, Zhang M, Zhang L, Wang P, Song G, Liu B, et al. Intracellular osteopontin stabilizes TRAF3 to positively regulate innate antiviral response. Sci Rep. 2016;6:23771 pubmed publisher
    ..Mechanistically, iOPN was found to interact with tumor necrosis factor receptor (TNFR)-associated factor 3 (TRAF3) and inhibit Triad3A-mediated K48-linked polyubiquitination and degradation of TRAF3 through the C-terminal ..
  61. Hildebrand J, Luo Z, Manske M, Price Troska T, Ziesmer S, Lin W, et al. A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling. J Exp Med. 2010;207:2569-79 pubmed publisher
    ..This mutation encodes a His159Tyr substitution in the cytoplasmic tail of BAFF-R adjacent to the TRAF3 binding motif...
  62. Mao H, Wang Y, Cai J, Meng J, Zhou Y, Pan Y, et al. HACE1 Negatively Regulates Virus-Triggered Type I IFN Signaling by Impeding the Formation of the MAVS-TRAF3 Complex. Viruses. 2016;8: pubmed publisher
    ..Mechanistic studies showed that HACE1 exerts its inhibitory role on virus-induced signaling by disrupting the MAVS-TRAF3 complex. Therefore, we uncovered a novel function of HACE1 in innate immunity regulation.
  63. Gao X, Pham T, Feuerbacher L, Chen K, Hays M, Singh G, et al. Citrobacter rodentium NleB Protein Inhibits Tumor Necrosis Factor (TNF) Receptor-associated Factor 3 (TRAF3) Ubiquitination to Reduce Host Type I Interferon Production. J Biol Chem. 2016;291:18232-8 pubmed publisher host IFN-? production by inhibiting Lys(63)-linked ubiquitination of TNF receptor-associated factor 3 (TRAF3). Inhibition was dependent on the glycosyltransferase activity of NleB...