TRADD

Summary

Gene Symbol: TRADD
Description: TNFRSF1A associated via death domain
Alias: Hs.89862, tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFR1-associated death domain protein, tumor necrosis factor receptor type 1 associated death domain protein, tumor necrosis factor receptor-1-associated protein
Species: human
Products:     TRADD

Top Publications

  1. Park A, Baichwal V. Systematic mutational analysis of the death domain of the tumor necrosis factor receptor 1-associated protein TRADD. J Biol Chem. 1996;271:9858-62 pubmed
    ..A TNF-R1-associated protein TRADD has been discovered that interacts with the death domain of the receptor...
  2. Izumi K, Kieff E. The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB. Proc Natl Acad Sci U S A. 1997;94:12592-7 pubmed
    ..TES2 interacting proteins, including the tumor necrosis factor receptor-associated death domain protein (TRADD). TRADD was the only protein that interacted with wild-type TES2 and not with isoleucine-mutated TES2...
  3. Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell. 2003;114:181-90 pubmed
    ..The initial plasma membrane bound complex (complex I) consists of TNFR1, the adaptor TRADD, the kinase RIP1, and TRAF2 and rapidly signals activation of NF-kappa B...
  4. Park Y, Ye H, Hsia C, Segal D, Rich R, Liou H, et al. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell. 2000;101:777-87 pubmed
    ..to activated TNF receptors either by direct interactions with the receptors or indirectly via the adaptor protein TRADD. We now report the structure of the TRADD-TRAF2 complex, which is highly distinct from receptor-TRAF2 interactions...
  5. Inada H, Izawa I, Nishizawa M, Fujita E, Kiyono T, Takahashi T, et al. Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD. J Cell Biol. 2001;155:415-26 pubmed
    ..We have now identified human TNF receptor type 1 (TNFR1)-associated death domain protein (TRADD) to be the K18-interacting protein...
  6. Sandu C, Gavathiotis E, Huang T, Wegorzewska I, Werner M. A mechanism for death receptor discrimination by death adaptors. J Biol Chem. 2005;280:31974-80 pubmed
    ..domains engage their binding partners has been explored by extensive mutagenesis of two death adaptors, FADD and TRADD, suggesting that a death adaptor can discriminate its intended binding partners from other proteins harboring ..
  7. Hsu H, Xiong J, Goeddel D. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell. 1995;81:495-504 pubmed
    ..We have identified a novel 34 kDa protein, designated TRADD, that specifically interacts with an intracellular domain of TNFR1 known to be essential for mediating programmed ..
  8. Hsu H, Shu H, Pan M, Goeddel D. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 1996;84:299-308 pubmed
    ..b>TRADD is a TNFR1-associated signal transducer that is involved in activating both pathways...
  9. Boldin M, Goncharov T, Goltsev Y, Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell. 1996;85:803-15 pubmed
    ..activation of these receptors, Fas/APO-1 binds a protein called MORT1 (or FADD) and p55-R binds a protein called TRADD. MORT1 and TRADD can also bind to each other. We have cloned a novel protein, MACH, that binds to MORT1...

More Information

Publications144 found, 100 shown here

  1. Vince J, Pantaki D, Feltham R, Mace P, Cordier S, Schmukle A, et al. TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis. J Biol Chem. 2009;284:35906-15 pubmed publisher
    ..These results show that TRAF2 has anti-apoptotic signaling roles in addition to promoting NF-kappaB signaling and that efficient activation of NF-kappaB by TNFR1 requires the recruitment of cIAP1/2 by TRAF2. ..
  2. Chio I, Sasaki M, Ghazarian D, Moreno J, Done S, Ueda T, et al. TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation. Nat Cell Biol. 2012;14:625-33 pubmed publisher
    Tumour necrosis factor receptor (TNFR)-associated death domain (TRADD) protein is a central adaptor in the TNFR1 signalling complex that mediates both cell death and inflammatory signals...
  3. Shu H, Takeuchi M, Goeddel D. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proc Natl Acad Sci U S A. 1996;93:13973-8 pubmed
    ..The association of TRADD, a 34-kDa cytoplasmic protein containing a C-terminal death domain, with aggregated TNF receptor 1 (TNF-R1) ..
  4. Sanz L, Sanchez P, Lallena M, Diaz Meco M, Moscat J. The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. EMBO J. 1999;18:3044-53 pubmed
    ..In this way, a signaling cascade of interactions is established from the TNF-R1 involving TRADD/RIP/p62/aPKCs/IKKbeta...
  5. Bender L, Morgan M, Thomas L, Liu Z, Thorburn A. The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm. Cell Death Differ. 2005;12:473-81 pubmed
    b>TNFR1 associated death domain protein (TRADD) contains an N-terminal TRAF binding domain and a C-terminal death domain along with nuclear import and export sequences that cause shuttling between the cytoplasm and nucleus...
  6. Ea C, Deng L, Xia Z, Pineda G, Chen Z. Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell. 2006;22:245-57 pubmed
    ..These results reveal the biochemical mechanism underlying the essential signaling function of NEMO and provide direct evidence that signal-induced site-specific ubiquitination of RIP1 is required for IKK activation. ..
  7. Tsao D, Hum W, Hsu S, Malakian K, Lin L. The NMR structure of the TRADD death domain, a key protein in the TNF signaling pathway. J Biomol NMR. 2007;39:337-42 pubmed
  8. Hsu H, Huang J, Shu H, Baichwal V, Goeddel D. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity. 1996;4:387-96 pubmed
    ..pathways leading to apoptosis and NF-kappa B activation through its interaction with the death domain protein TRADD. Here, we show that TRADD interacts strongly with RIP, another death domain protein that was shown previously to ..
  9. Li X, Wang Y, Debatin K, Hug H. The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells. Biochem Biophys Res Commun. 2000;277:513-7 pubmed
    ..Here we describe that HIPK2 can also associate with TRADD, a protein that interacts with tumor necrosis factor receptor type 1 (TNF-R1)...
  10. Zheng L, Bidere N, Staudt D, Cubre A, Orenstein J, Chan F, et al. Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. Mol Cell Biol. 2006;26:3505-13 pubmed
    ..The TNFR-associated death domain (TRADD) protein has been suggested to be a crucial signal adaptor that mediates all intracellular responses from TNFR1...
  11. Tsao D, McDonagh T, Telliez J, Hsu S, Malakian K, Xu G, et al. Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway. Mol Cell. 2000;5:1051-7 pubmed
    b>TRADD is a multifunctional signaling adaptor protein that is recruited to TNFR1 upon ligand binding...
  12. Poyet J, Srinivasula S, Lin J, Fernandes Alnemri T, Yamaoka S, Tsichlis P, et al. Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization. J Biol Chem. 2000;275:37966-77 pubmed
  13. Zhang H, Zhang R, Luo Y, D Alessio A, Pober J, Min W. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. J Biol Chem. 2004;279:44955-65 pubmed
    ..in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD, RIP1, TRAF2, and AIPl...
  14. Jones S, Ledgerwood E, Prins J, Galbraith J, Johnson D, Pober J, et al. TNF recruits TRADD to the plasma membrane but not the trans-Golgi network, the principal subcellular location of TNF-R1. J Immunol. 1999;162:1042-8 pubmed
    ..The subcellular interactions of TNF-R1 and the TRADD (TNFR-associated death domain protein) adaptor protein have been analyzed in the human monocyte cell line U937 and ..
  15. Malinin N, Boldin M, Kovalenko A, Wallach D. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature. 1997;385:540-4 pubmed
    ..and blocks its induction by TNF, by either of the two TNF receptors or by the receptor CD95 (Fas/Apo-1), and by TRADD, RIP and MORT1/FADD, which are adaptor proteins that bind to these receptors...
  16. Lu H, Zhang L, Gu L, Hou B, Du G. Oxymatrine Induces Liver Injury through JNK Signalling Pathway Mediated by TNF-? In Vivo. Basic Clin Pharmacol Toxicol. 2016;119:405-11 pubmed publisher
    ..up-regulated expressions of tumour necrosis factor receptor l (TNFR1), TNF receptor-associated structure domain (TRADD) and phosphorylation of stress-activated protein kinase/c-jun N-terminal protein kinases (p-SAPK/JNK)...
  17. Gallelli L, Falcone D, Scaramuzzino M, Pelaia G, D Agostino B, Mesuraca M, et al. Effects of simvastatin on cell viability and proinflammatory pathways in lung adenocarcinoma cells exposed to hydrogen peroxide. BMC Pharmacol Toxicol. 2014;15:67 pubmed publisher
    ..components of the signaling complex activated by innate immune responses, including MyD88, TRAF2, TRAF6 and TRADD. In conclusion, these findings suggest that simvastatin could play a role in prevention and treatment of lung ..
  18. Tran A, Han S, Kim J, Grasso F, Kim I, Han Y. MutY DNA Glycosylase Protects Cells From Tumor Necrosis Factor Alpha-Induced Necroptosis. J Cell Biochem. 2017;118:1827-1838 pubmed publisher
    ..in vitro studies have shown that MYH interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD), a key effector protein of tumor necrosis factor receptor-1 (TNFR1) signaling...
  19. Xiao Y, Geng Z, Deng T, Wang D, Jiang L. Tumor Necrosis Factor Receptor Type 1-Associated Death Domain Protein Is a Potential Prognostic Biomarker in Acute Myeloid Leukemia. Am J Med Sci. 2019;357:111-115 pubmed publisher
    Tumor necrosis factor receptor type 1-associated death domain protein (TRADD) mediates programmed cell death signaling as well as the Fas-induced cell death pathway...
  20. Maruyama T, Yamamoto S, Qiu J, Ueda Y, Suzuki T, Nojima M, et al. Apoptosis of bladder cancer by sodium butyrate and cisplatin. J Infect Chemother. 2012;18:288-95 pubmed publisher
    ..Western blot analysis was used to determine expression of p21, p27, TRADD, FADD, caspase-2, and caspase-7...
  21. Khan Z, Labala R, Yumnamcha T, Devi S, Mondal G, Sanjita Devi H, et al. Artificial Light at Night (ALAN), an alarm to ovarian physiology: A study of possible chronodisruption on zebrafish (Danio rerio). Sci Total Environ. 2018;628-629:1407-1421 pubmed publisher
    ..RNA-Seq data of ovarian samples revealed the upregulation of Mid2, Tfg, Irak1, Pim2, Tradd, Tmem101, Nfkbib genes and ultimately increase the expression of NF-?B, a cellular transformer for tumourigenesis, ..
  22. Jiang Y, Woronicz J, Liu W, Goeddel D. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science. 1999;283:543-6 pubmed
    ..TNF treatment released SODD from TNF-R1, permitting the recruitment of proteins such as TRADD and TRAF2 to the active TNF-R1 signaling complex...
  23. Ryu S, Chae S, Kim E. Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9. Biochem Biophys Res Commun. 2000;279:6-10 pubmed
    ..Colocalization of Fas, sentrin, and Ubc9 binding regions suggests the importance of that region upon the regulation of Daxx. Our data also demonstrated that sentrin could homooligomerize by protein-protein interaction. ..
  24. Cao Y, Cheng F, Yao W, Bao B, Zhang K, Zhang L, et al. Toxicity of Pekinenin C from Euphorbia Pekinensis Radix on Rat Small Intestinal Crypt Epithelial Cell and Its Apoptotic Mechanism. Int J Mol Sci. 2016;17: pubmed publisher
    ..apoptosis-inducing factor (AIF), Apaf-1, Fas-associated death domain (FADD) and type 1-associated death domain (TRADD) by Western-blot, mRNA expression of Fas receptor (FasR), Fas ligand (FasL), tumor necrosis factor receptor (TNFR1)..
  25. Kuai J, Wooters J, Hall J, Rao V, Nickbarg E, Li B, et al. NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach. J Biol Chem. 2004;279:53266-71 pubmed
    ..TNFR complexes in human myelomonocytic U937 cells. Seven proteins were identified, including TRADD, TRAP2, and TRAF2, which are three proteins known to be recruited to TNFalpha receptors...
  26. Fritsch J, Stephan M, Tchikov V, Winoto Morbach S, Gubkina S, Kabelitz D, et al. Cell fate decisions regulated by K63 ubiquitination of tumor necrosis factor receptor 1. Mol Cell Biol. 2014;34:3214-28 pubmed publisher
    ..Conversely, recruitment of the adaptor proteins TRADD, TRAF2, and RIP1 to TNF-R1, as well as activation of NF-?B, was unimpeded and cell growth and proliferation were ..
  27. Chang X, Wang L, Wang Z, Wu S, Zhu X, Hu S, et al. TRADD mediates the tumor necrosis factor-induced apoptosis of L929 cells in the absence of RIP3. Sci Rep. 2017;7:16111 pubmed publisher
    ..Although both TNF receptor type 1-associated death domain protein (TRADD) and RIP1 have been reported to mediate TNF?-induced apoptosis, the knockdown of TRADD, but not RIP1, suppressed ..
  28. Guan Y, Zhang Z, Yu C, Ma L, Hu W, Xu L, et al. Phospho-SXXE/D motif mediated TNF receptor 1-TRADD death domain complex formation for T cell activation and migration. J Immunol. 2011;187:1289-97 pubmed publisher
    In TNF-treated cells, TNFR1, TNFR-associated death domain protein (TRADD), Fas-associated death domain protein, and receptor-interacting protein kinase proteins form the signaling complex via modular interaction within their C-terminal ..
  29. Schutze S, Machleidt T, Adam D, Schwandner R, Wiegmann K, Kruse M, et al. Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling. J Biol Chem. 1999;274:10203-12 pubmed
    ..receptor for tumor necrosis factor (TR55) triggers multiple signaling cascades initiated by adapter proteins like TRADD and FAN...
  30. Scheuerpflug C, Lichter P, Debatin K, Mincheva A. Assignment of TRADD to human chromosome band 16q22 by in situ hybridization. Cytogenet Cell Genet. 2001;92:347-8 pubmed
  31. Cerhan J, Liu Mares W, Fredericksen Z, Novak A, Cunningham J, Kay N, et al. Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma. Cancer Epidemiol Biomarkers Prev. 2008;17:3161-9 pubmed publisher
    ..polymorphisms (SNP) within TNF, lymphotoxin A LTA, and nine NF-kappaB genes from the canonical pathway (TNFRSF1A, TRADD, TRAF2, TRAF5, RIPK1, CHUK, IKBKB, NFKB1, and REL) in a clinic-based study of 441 incident cases and 475 frequency-..
  32. Li Y, Sheng K, Chen J, Wu Y, Zhang F, Chang Y, et al. Regulation of PGE2 signaling pathways and TNF-alpha signaling pathways on the function of bone marrow-derived dendritic cells and the effects of CP-25. Eur J Pharmacol. 2015;769:8-21 pubmed publisher
    ..The proliferation of T cells co-cultured with DCs, the signaling pathways of PGE2-EP4-cAMP and TNF-alpha-TRADD-TRAF2-NF-κB in DCs were analyzed...
  33. Jiang Y, Yu M, Hu X, Han L, Yang K, Ba H, et al. STAT1 mediates transmembrane TNF-alpha-induced formation of death-inducing signaling complex and apoptotic signaling via TNFR1. Cell Death Differ. 2017;24:660-671 pubmed publisher
    ..sTNF-α induces binding of tumor necrosis factor receptor type 1-associated death domain protein (TRADD) to the death domain (DD) of TNFR1 and subsequent activation of nuclear factor kappa B (NF-κB), and the ..
  34. Zhu L, Yang X, Chen W, Li X, Ji Y, Mao H, et al. Decreased expressions of the TNF-alpha signaling adapters in peripheral blood mononuclear cells (PBMCs) are correlated with disease activity in patients with systemic lupus erythematosus. Clin Rheumatol. 2007;26:1481-9 pubmed
    ..to investigate the expression of mRNA for the TNF adapter proteins including TNF receptor-associated death domain (TRADD) protein, Fas-associated death domain (FADD) protein, receptor-interacting protein 1 (RIP-1), and TNF receptor-..
  35. Kumari S, Redouane Y, Lopez Mosqueda J, Shiraishi R, Romanowska M, Lutzmayer S, et al. Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. elife. 2014;3: pubmed publisher
    ..Here we show that TNF receptor 1 (TNFR1)-associated death domain (TRADD)-dependent TNFR1 signaling in epidermal keratinocytes drives skin inflammation in Sharpin-deficient mice...
  36. Kieser A, Sterz K. The Latent Membrane Protein 1 (LMP1). Curr Top Microbiol Immunol. 2015;391:119-49 pubmed publisher
    ..with tumor necrosis factor receptors such as tumor necrosis factor receptor-associated factor (TRAF) proteins and TRADD to mimic signals of the costimulatory CD40 receptor in the EBV-infected B lymphocyte...
  37. Fahrioğlu U, Dodurga Y, Elmas L, Seçme M. Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro. Gene. 2016;576:476-82 pubmed publisher
    ..D1),CDK4, CDK6, RB, p21, p16, p53, caspase-3, caspase-9, caspase-8, caspase-10, Bcl-2, BCL-XL,BID, DR4,DR5,FADD,TRADD,PARP, APAF, Bax, Akt, PTEN, PUMA, NOXA, MMP2, MMP9, TIMP1 and TIMP2 were determined by real-time PCR...
  38. Tarhouni Jabberi S, Zakraoui O, Ioannou E, Riahi Chebbi I, Haoues M, Roussis V, et al. Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-κB Signaling. Mar Drugs. 2017;15: pubmed publisher
    ..Besides, the level of death receptor-associated protein TRADD increased significantly in a concentration-dependent manner...
  39. Anderton H, Bandala Sanchez E, Simpson D, Rickard J, Ng A, Di Rago L, et al. RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development. Cell Death Differ. 2019;26:877-889 pubmed publisher
    ..b>TRADD is a death domain (DD) containing molecule that mediates signaling downstream of TNFR1 and the TLRs...
  40. Skaug B, Chen J, Du F, He J, Ma A, Chen Z. Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell. 2011;44:559-71 pubmed publisher
    ..Our results suggest a noncatalytic mechanism of IKK inhibition by A20 and a means by which polyubiquitin chains can specify a signaling outcome. ..
  41. Pearson J, Giogha C, Ong S, Kennedy C, Kelly M, Robinson K, et al. A type III effector antagonizes death receptor signalling during bacterial gut infection. Nature. 2013;501:247-51 pubmed publisher
    ..Protein interaction studies identified FADD, TRADD and RIPK1 as binding partners of NleB1...
  42. Papoff G, Trivieri N, Marsilio S, Crielesi R, Lalli C, Castellani L, et al. N-terminal and C-terminal domains of calmodulin mediate FADD and TRADD interaction. PLoS ONE. 2015;10:e0116251 pubmed publisher
    FADD (Fas-associated death domain) and TRADD (Tumor Necrosis Factor Receptor 1-associated death domain) proteins are important regulators of cell fate in mammalian cells...
  43. Lu J, Li Y, Shen Z, Lu C, Lu L. TNF-? is involved in apoptosis triggered by grass carp reovirus infection in vitro. Fish Shellfish Immunol. 2016;55:559-67 pubmed publisher
    ..TNF-? triggered significant apoptosis in CIK cells, which was characterized by increased mRNA levels of TNF-?, TRADD or caspase-8, and enhanced caspase-8 activity in CIK cells...
  44. Pan G, Bauer J, Haridas V, Wang S, Liu D, Yu G, et al. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 1998;431:351-6 pubmed
    ..DR6 interacts with TRADD, which has previously been shown to associate with TNFR1...
  45. Fries K, Miller W, Raab Traub N. The A20 protein interacts with the Epstein-Barr virus latent membrane protein 1 (LMP1) and alters the LMP1/TRAF1/TRADD complex. Virology. 1999;264:159-66 pubmed publisher
    ..of LMP1 with the TRAF molecules, whereas CTAR2 interacts with the TNFR-associated death domain protein (TRADD) to activate NF-kB and the c-Jun N-terminal kinase (JNK)...
  46. Park K, Choi S, Lee S, Hwang S, Lai M. Nonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor alpha-stimulated nuclear factor kappa B activation. J Biol Chem. 2002;277:13122-8 pubmed publisher
    ..Our findings suggest a possible molecular mechanism that could explain the ability of NS5A to negatively regulate TNF-alpha-induced NF-kappaB activation...
  47. Hedl M, Abraham C. A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1. Proc Natl Acad Sci U S A. 2014;111:13451-6 pubmed publisher
    ..to PRR outcomes included TACE-induced TNFSF15 cleavage to soluble TNFSF15; soluble TNFSF15 then led to TRADD/FADD/MALT-1- and caspase-8-mediated autocrine IL-1 secretion...
  48. Wang F, Weng H, Quon M, Yu J, Wang J, Hueber A, et al. Dominant negative FADD dissipates the proapoptotic signalosome of the unfolded protein response in diabetic embryopathy. Am J Physiol Endocrinol Metab. 2015;309:E861-73 pubmed publisher
    ..Diabetes increases tumor necrosis factor receptor type 1R-associated death domain (TRADD) expression...
  49. Parthipan S, Selvaraju S, Somashekar L, Arangasamy A, Sivaram M, Ravindra J. Spermatozoal transcripts expression levels are predictive of semen quality and conception rate in bulls (Bos taurus). Theriogenology. 2017;98:41-49 pubmed publisher
    ..The expression level of TRADD had significant negative influence on the mitochondrial membrane potential (r = -0.54, p = 0...
  50. Feng X, Gaeta M, Madge L, Yang J, Bradley J, Pober J. Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors. J Biol Chem. 2001;276:8341-9 pubmed
    ..TNF stimulation, is directly recruited to the intracellular region of TNF receptor 2 (TNFR2) or indirectly, via TRADD, to the intracellular region of TNF receptor 1 (TNFR1)...
  51. Jang H, Chung Y, Baik J, Choi Y, Park I, Jung Y, et al. Caspase-cleaved TRAF1 negatively regulates the antiapoptotic signals of TRAF2 during TNF-induced cell death. Biochem Biophys Res Commun. 2001;281:499-505 pubmed
    ..These results indicate that caspase-dependent cleavage of TRAF1 generates TRAF1-c fragments that are able to bind TRAF2, and then sequester TRAF2 from the TNF-R1 complex, rendering cells, at least in part, sensitive to TNF. ..
  52. Kaklamanos A, Rozman J, Roulis M, Karagianni N, Armaka M, Wu M, et al. Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression. Sci Rep. 2017;7:2397 pubmed publisher
    ..Notably, this phenotype was independent of TNF-TNFR1 signaling since the genetic ablation of either Tnf or Tradd did not rescue the phenotype...
  53. Hammouda M, Riahi Chebbi I, Souid S, Othman H, Aloui Z, Srairi Abid N, et al. Macrovipecetin, a C-type lectin from Macrovipera lebetina venom, inhibits proliferation migration and invasion of SK-MEL-28 human melanoma cells and enhances their sensitivity to cisplatin. Biochim Biophys Acta Gen Subj. 2018;1862:600-614 pubmed publisher
    ..Moreover, macrovipecetin alone or combined with cisplatin induced the expression of TRADD, p53, Bax, Bim and Bad and down-regulated the Bcl-2 expression and ROS levels in SK-MEL-28 cells...
  54. Tada K, Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, et al. Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. J Biol Chem. 2001;276:36530-4 pubmed
    ..Collectively, these results indicate that both TRAF2 and TRAF5 are involved in TNF-induced NF-kappaB activation and protection from cell death. ..
  55. Hunter I, Nixon G. Spatial compartmentalization of tumor necrosis factor (TNF) receptor 1-dependent signaling pathways in human airway smooth muscle cells. Lipid rafts are essential for TNF-alpha-mediated activation of RhoA but dispensable for the activation of the NF-. J Biol Chem. 2006;281:34705-15 pubmed
    ..TNF-alpha engagement of TNFR1 recruited the adaptor proteins TRADD, TRAF-2, and RIP into lipid rafts and activated RhoA, NF-kappaB, and MAPK pathways...
  56. Schneider F, Neugebauer J, Griese J, Liefold N, Kutz H, Briseño C, et al. The viral oncoprotein LMP1 exploits TRADD for signaling by masking its apoptotic activity. PLoS Biol. 2008;6:e8 pubmed publisher
    The tumor necrosis factor (TNF)-receptor 1-associated death domain protein (TRADD) mediates induction of apoptosis as well as activation of NF-kappaB by cellular TNF-receptor 1 (TNFR1)...
  57. Zhu L, Yang X, Ji Y, Chen W, Guan W, Zhou S, et al. Up-regulated renal expression of TNF-alpha signalling adapter proteins in lupus glomerulonephritis. Lupus. 2009;18:116-27 pubmed publisher
    ..of TNF-alpha and TNF signalling adapter proteins, including TNF receptor-associated death domain protein (TRADD), receptor-interacting protein (RIP) and TNF receptor-associated factor-2 (TRAF-2) in patients with LN...
  58. Shilpa M, Selvaraju S, GirishKumar V, Parthipan S, Binsila K, Arangasamy A, et al. Novel insights into the role of cell-free seminal mRNAs on semen quality and cryotolerance of spermatozoa in bulls (Bos taurus). Reprod Fertil Dev. 2017;29:2446-2456 pubmed publisher
    ..2 (BMP2), ubiquitin conjugating enzyme E2D3 (UBE2D3), tumour-associated necrotic factor-associated death domain (TRADD) and caspase-3 (CASP3) expression. Nerve growth factor (NGF) expression was positively (P<0...
  59. Costanzo A, Guiet C, Vito P. c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB. J Biol Chem. 1999;274:20127-32 pubmed
    ..superfamily induce apoptosis via interaction with FADD and regulate cell growth and differentiation through TRADD and TRAFs molecules...
  60. Rokudai S, Fujita N, Kitahara O, Nakamura Y, Tsuruo T. Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis. Mol Cell Biol. 2002;22:8695-708 pubmed
    ..With a cDNA microarray, we revealed that tumor necrosis factor receptor-associated death domain (tradd) gene expression was elevated in response to Akt inactivation...
  61. Chaves Neto A, Pelizzaro Rocha K, Fernandes M, Ferreira Halder C. Antitumor activity of irradiated riboflavin on human renal carcinoma cell line 786-O. Tumour Biol. 2015;36:595-604 pubmed publisher
    ..FasL/Fas) and tumor necrosis factor receptor superfamily, member 1a (TNFR1)/TNFRSF1A-associated via death domain (TRADD)/TNF receptor-associated factor 2 (TRAF) signaling pathways (the extrinsic apoptosis pathway), while the intrinsic ..
  62. Chang L, Yu Y, Liu C, Cheng Y, Chou R, Hsieh M, et al. The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1. Cancer Chemother Pharmacol. 2015;75:1303-15 pubmed publisher
    ..CSC-3436-induced apoptosis was accompanied by the activation of pro-apoptotic factors FADD, TRADD, and RIP and the inactivation of anti-apoptotic proteins Bcl-2 and Bcl-xL, resulting in the cleavage and ..
  63. Luzio A, Matos M, Santos D, Fontaínhas Fernandes A, Monteiro S, Coimbra A. Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17?-ethinylestradiol and fadrozole exposures. Aquat Toxicol. 2016;177:269-84 pubmed publisher
    ..The death receptors (FAS; TRADD), anti-apoptotic (BCL-2; MDM2), pro-apoptotic (CASP-2 and -6) and cell proliferation (BIRC5/survivin; JUN) genes ..
  64. Galluzzi L, Joza N, Tasdemir E, Maiuri M, Hengartner M, Abrams J, et al. No death without life: vital functions of apoptotic effectors. Cell Death Differ. 2008;15:1113-23 pubmed publisher
  65. McIntosh K, Cunningham M, Cadalbert L, Lockhart J, Boyd G, Ferrell W, et al. Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs. Cell Signal. 2010;22:265-73 pubmed publisher
    ..Activation of PAR(2) was found to disrupt TNFR1 binding to RIP and TRADD and this was reversed by both GF109203X and YM25480...
  66. Chattopadhyay A, Hood B, Conrads T, Redner R. Extrinsic apoptosis is impeded by direct binding of the APL fusion protein NPM-RAR to TRADD. Mol Cancer Res. 2014;12:1283-91 pubmed publisher
    ..TNF receptor type I-associated DEATH domain protein (TRADD) was identified as a relevant binding partner for NPM-RAR...
  67. Sindhu R, Manonmani H. l-asparaginase induces intrinsic mitochondrial-mediated apoptosis in human gastric adenocarcinoma cells and impedes tumor progression. Biochem Biophys Res Commun. 2018;503:2393-2399 pubmed publisher
    ..05), while anti-apoptotic markers xiap, bid, mcl1, and death receptor genes tnf and tradd were significantly down-regulated (P < 0.05)...
  68. Davidson S, Liu Y, Danoy P, Wu X, Thomas G, Jiang L, et al. Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese. Ann Rheum Dis. 2011;70:289-92 pubmed publisher
    ..were genotyped for 115 single nucleotide polymorphisms (SNPs) tagging IL23R, ERAP1, STAT3, JAK2, TNFRSF1A and TRADD, as well as other confirmation SNPs from the TASC study, using the Sequenom iPlex and the ABI OpenArray platforms...
  69. Mahul Mellier A, Pazarentzos E, Datler C, Iwasawa R, Abuali G, Lin B, et al. De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF. Cell Death Differ. 2012;19:891-9 pubmed publisher
    ..Consequently, downregulation of USP2a promotes NF-?B activation and protects cells against TNF-induced cell death. ..
  70. Liu Y, Lu D, Sheng J, Luo L, Zhang W. Identification of TRADD as a potential biomarker in human uterine leiomyoma through iTRAQ based proteomic profiling. Mol Cell Probes. 2017;36:15-20 pubmed publisher
    ..72 proteins have been identified as differentially expressed in uterine leiomyoma, including the downregulation of TRADD (tumor necrosis factor receptor type 1-associated DEATH domain protein), which dominates the dysfunctional ..
  71. Legler D, Micheau O, Doucey M, Tschopp J, Bron C. Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity. 2003;18:655-64 pubmed
    ..microdomains, termed lipid rafts, where it associates with the Ser/Thr kinase RIP and the adaptor proteins TRADD and TRAF2, forming a signaling complex. In lipid rafts, TNFR1 and RIP are ubiquitylated...
  72. Qi Z, Shen L, Zhou H, Jiang Y, Lan L, Luo L, et al. Phosphorylation of heat shock protein 27 antagonizes TNF-? induced HeLa cell apoptosis via regulating TAK1 ubiquitination and activation of p38 and ERK signaling. Cell Signal. 2014;26:1616-25 pubmed publisher
    ..In addition, we also found that increased HSP27 phosphorylation inhibited TRADD ubiquitination but did not influence the binding between TRADD and FADD in a pro-apoptotic complex...
  73. Zhan X, Mu Y, Pan C, Xiao Y, Lu Z, Liu F, et al. Life and death of human vascular endothelial cells by stimulation with free fatty acids through death receptors. Horm Metab Res. 2015;47:107-13 pubmed publisher
    ..PA induced the apoptosis of HUVECs by initiating the death pathway (TNF-R1/TRADD/caspases 8 pathway), whereas AA enhanced cell survival to protect vascular endothelial cells by activating the ..
  74. Cho Y, Challa S, Moquin D, Genga R, Ray T, Guildford M, et al. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell. 2009;137:1112-23 pubmed publisher
    ..Our findings suggest that RIP3 controls programmed necrosis by initiating the pronecrotic kinase cascade, and that this is necessary for the inflammatory response against virus infections. ..
  75. Günster R, Matthews S, Holden D, Thurston T. SseK1 and SseK3 Type III Secretion System Effectors Inhibit NF-κB Signaling and Necroptotic Cell Death in Salmonella-Infected Macrophages. Infect Immun. 2017;85: pubmed publisher
    ..Indeed, SseK1 caused the GlcNAcylation of the death domain-containing proteins FADD and TRADD, whereas SseK3 expression resulted in weak GlcNAcylation of TRADD but not FADD...
  76. Morgan M, Thorburn J, Pandolfi P, Thorburn A. Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms. J Cell Biol. 2002;157:975-84 pubmed
    The adapter protein tumor necrosis factor receptor (TNFR)1-associated death domain (TRADD) plays an essential role in recruiting signaling molecules to the TNFRI receptor complex at the cell membrane...
  77. Jeon J, Lee J, Park K, Byun H, Lee H, Lee Y, et al. Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components. Biochem Pharmacol. 2014;89:515-25 pubmed publisher
    ..Taken together, the results suggest that the anti-IKK activity of brazilin is induced by targeting IKK upstream signaling components and subsequently disrupting proximal IL-1 receptor signaling complex formation. ..
  78. Mahata B, Biswas S, Rayman P, Chahlavi A, Ko J, Bhattacharjee A, et al. GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway. PLoS ONE. 2015;10:e0134425 pubmed publisher
    ..with the TNF receptor and co-immunoprecipitation experiments showed recruitment of death domains FADD and TRADD with the TNF receptor post ganglioside treatment, suggesting direct interaction of gangliosides with the TNF ..
  79. Guesmi F, Prasad S, Tyagi A, Landoulsi A. Antinflammatory and anticancer effects of terpenes from oily fractions of Teucruim alopecurus, blocker of I?B? kinase, through downregulation of NF-?B activation, potentiation of apoptosis and suppression of NF-?B-regulated gene expression. Biomed Pharmacother. 2017;95:1876-1885 pubmed publisher
    ..Finally, the activation of nuclear factor-?B induced by different plasmids (TNFR1, TRADD, TRAF2, NIK, TAK1/TAB1, and IKK?) was inhibited following treatment with TA-1...
  80. Pointon J, Harvey D, Karaderi T, Appleton L, Farrar C, Stone M, et al. The chromosome 16q region associated with ankylosing spondylitis includes the candidate gene tumour necrosis factor receptor type 1-associated death domain (TRADD). Ann Rheum Dis. 2010;69:1243-6 pubmed publisher
    ..as the highly plausible candidate gene, tumour necrosis factor receptor type 1 (TNFR1)-associated death domain (TRADD), is located between rs9033 and rs868213...
  81. Pobezinskaya Y, Choksi S, Morgan M, Cao X, Liu Z. The adaptor protein TRADD is essential for TNF-like ligand 1A/death receptor 3 signaling. J Immunol. 2011;186:5212-6 pubmed publisher
    TNFR-associated death domain protein (TRADD) is a key effector protein of TNFR1 signaling. However, the role of TRADD in other death receptor (DR) signaling pathways, including DR3, has not been completely characterized...
  82. Gaud G, Guillemot D, Jacob Y, Favre M, Vuillier F. EVER2 protein binds TRADD to promote TNF-?-induced apoptosis. Cell Death Dis. 2013;4:e499 pubmed publisher
    ..We show here that EVER2 induces TNF-?- and TRAIL-dependant apoptosis. It interacts with the N-terminal domain of TRADD, impairs the recruitment of TRAF2 and RIPK1 and promotes apoptosis...
  83. Lim R, Barker G, Lappas M. TLR2, TLR3 and TLR5 regulation of pro-inflammatory and pro-labour mediators in human primary myometrial cells. J Reprod Immunol. 2017;122:28-36 pubmed publisher
    ..transfected with siRNA against TIRAP, IRAK1, IRAK4, TAK1and stimulated with bacterial product fsl-1 (TLR2); TRIF, TRADD, TRAF6, RIP1, TAK1 and stimulated with dsRNA viral analogue poly(I:C) (TLR3); IRAK1, IRAK4, TAK1 and stimulated ..
  84. Pan G, O Rourke K, Chinnaiyan A, Gentz R, Ebner R, Ni J, et al. The receptor for the cytotoxic ligand TRAIL. Science. 1997;276:111-3 pubmed
    ..Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis. ..
  85. Wang Y, Wu T, Cai S, Welte T, Chin Y. Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation. Mol Cell Biol. 2000;20:4505-12 pubmed
    ..Activated tumor necrosis factor alpha (TNF-alpha) receptor 1 (TNFR1) recruits TNFR1-associated death domain protein (TRADD), which in turn triggers two opposite signaling pathways leading to caspase activation for apoptosis induction and ..
  86. Dechant M, Scheuerpflug C, Pauly E, van der Werff Ten Bosch J, Debatin K, Fellenberg J. Screening, identification, and functional analysis of three novel missense mutations in the TRADD gene in children with ALL and ALPS. Pediatr Blood Cancer. 2008;51:616-20 pubmed publisher
    ..To investigate the role of the apoptosis adaptor molecules TRADD and FADD in the development of hematological diseases, patient samples were screened for mutations in these genes...
  87. Kolliputi N, Waxman A. IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation. Am J Respir Cell Mol Biol. 2009;40:314-24 pubmed publisher
    ..Furthermore, the interaction between SOCS-1 and ASK-1 promotes ubiquitin-mediated degradation both in vivo and in vitro. These studies demonstrate that SOCS-1 is an important regulator in IL-6-induced cytoprotection against HALI. ..
  88. Park Y, Jeong M, Jang S. Death domain complex of the TNFR-1, TRADD, and RIP1 proteins for death-inducing signaling. Biochem Biophys Res Commun. 2014;443:1155-61 pubmed publisher
    ..TNFR-1-associated death domain (TRADD) protein is an adapter molecule that bridges the interaction between TNFR-1 and receptor-interacting serine/..
  89. Li X, Jin Q, Wu Y, Sun P, Jiang S, Zhang Y, et al. Tetrandrine regulates hepatic stellate cell activation via TAK1 and NF-?B signaling. Int Immunopharmacol. 2016;36:263-270 pubmed publisher
    ..25?M) prior to TNF-? treatment reduced the expression of ?-SMA and TNFR-1-associated death domain (TRADD)...
  90. He M, Wang M, Huang Y, Peng W, Zheng Z, Xia N, et al. The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1. Sci Rep. 2016;6:27597 pubmed publisher
    ..Intriguingly, tumor necrosis factor receptor 1-associated death domain protein (TRADD) expression and receptor-interacting protein kinase 1 (RIP1) K63-ubiquitination were reduced in the presence of ..
  91. Chang Y, Chen T, Wu Y, Chen G, Weng T, Tseng P, et al. A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction. J Cell Mol Med. 2014;18:1344-57 pubmed publisher
    ..In summary, our results reveal a novel route of TLR signal that synergistically amplifies TNF-mediated responses, indicating an innovative target for inflammation manipulation. ..
  92. Eroğlu C, Seçme M, Bağcı G, Dodurga Y. Assessment of the anticancer mechanism of ferulic acid via cell cycle and apoptotic pathways in human prostate cancer cell lines. Tumour Biol. 2015;36:9437-46 pubmed publisher
    ..suppressed cell proliferation by increasing in the gene expressions of CASP1, CASP2, CASP8, CYCS, FAS, FASLG, and TRADD and decreasing in the gene expressions of BCL2 and XIAP in LNCaP cells...