Gene Symbol: TRA
Description: T cell receptor alpha locus
Alias: IMD7, TCRA, TCRD, TRA@, TRAC, T-cell antigen receptor, alpha polypeptide, T-cell receptor, alpha (V,D,J,C), TCRA, TRA@
Species: human
Products:     TRA

Top Publications

  1. Hallmayer J, Faraco J, Lin L, Hesselson S, Winkelmann J, Kawashima M, et al. Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet. 2009;41:708-11 pubmed publisher
    ..with replication in three ethnic groups, we found association between narcolepsy and polymorphisms in the TRA@ (T-cell receptor alpha) locus, with highest significance at rs1154155 (average allelic odds ratio 1...
  2. Ding Y, Smith K, Garboczi D, Utz U, Biddison W, Wiley D. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity. 1998;8:403-11 pubmed
    ..The existence of a structurally similar diagonal binding mode for TCRs favors mechanisms based on the formation of geometrically defined supramolecular assemblies for initiating signaling. ..
  3. Hennecke J, Wiley D. Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivi. J Exp Med. 2002;195:571-81 pubmed
    ..7/DR4/HA complex with the structure of DR4 presenting a collagen peptide. This structural study of TCR cross-reactivity emphasizes how MHC sequence differences can affect TCR binding indirectly by moving peptide atoms. ..
  4. Kjer Nielsen L, Clements C, Brooks A, Purcell A, McCluskey J, Rossjohn J. The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance. Structure. 2002;10:1521-32 pubmed
    ..The findings suggest a structural basis for the immunodominance of this clonotype in the immune response to EBV. ..
  5. Stewart Jones G, McMichael A, Bell J, Stuart D, Jones E. A structural basis for immunodominant human T cell receptor recognition. Nat Immunol. 2003;4:657-63 pubmed
    ..This previously unknown binding mode underlies the immunodominant T cell response. ..
  6. Fuschiotti P, Pasqual N, Hierle V, Borel E, London J, Marche P, et al. Analysis of the TCR alpha-chain rearrangement profile in human T lymphocytes. Mol Immunol. 2007;44:3380-8 pubmed
  7. Hor H, Kutalik Z, Dauvilliers Y, Valsesia A, Lammers G, Donjacour C, et al. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nat Genet. 2010;42:786-9 pubmed publisher
    ..Cases almost never carried a trans DRB1*1301-DQB1*0603 haplotype (odds ratio = 0.02; P < 6 x 10(-14)). This unexpected protective HLA haplotype suggests a virtually causal involvement of the HLA region in narcolepsy susceptibility...
  8. Borbulevych O, Piepenbrink K, Baker B. Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics. J Immunol. 2011;186:2950-8 pubmed publisher
  9. Wang Q, Liu Y, Soetandyo N, Baek K, HEGDE R, Ye Y. A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation. Mol Cell. 2011;42:758-70 pubmed publisher
    ..Our results reveal a ubiquitin ligase-associated holdase that maintains polypeptide solubility to enhance protein quality control in mammalian cells. ..

More Information

Publications131 found, 100 shown here

  1. Han F, Lin L, Li J, Aran A, Dong S, An P, et al. TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy. Sleep Med. 2012;13:269-72 pubmed publisher
    Polymorphisms in the TCRA and P2RY11, two immune related genes, are associated with narcolepsy in Caucasians and Asians...
  2. Vallejo Díez S, Fleischer A, Martín Fernández J, Sanchez Gilabert A, Bachiller D. Generation of two induced pluripotent stem cells lines from a Mucopolysaccharydosis IIIB (MPSIIIB) patient. Stem Cell Res. 2018;33:180-184 pubmed publisher
    ..Regarding the iPSC phenotype, both lines expressed the pluripotency-associated markers: OCT3/4, NANOG, SOX2 and TRA-1-60 (Fig. 1E), and TRA-1-81 quantified by flow cytometry (Fig. 1G), resulting in 88.17% and 83...
  3. Alagrafi F, Alawad A, Abutaha N, Nasr F, Alhazzaa O, Alharbi S, et al. In vitro induction of human embryonal carcinoma differentiation by a crude extract of Rhazya stricta. BMC Complement Altern Med. 2017;17:342 pubmed publisher
    ..In addition, the surface antigen pluripotency marker, TRA-1-60, was strongly down-regulated...
  4. Zhai Y, He Z, Kang Y, Yu H, Wang J, Du P, et al. Complete nucleotide sequence of pH11, an IncHI2 plasmid conferring multi-antibiotic resistance and multi-heavy metal resistance genes in a clinical Klebsiella pneumoniae isolate. Plasmid. 2016;86:26-31 pubmed publisher
    ..plasmid exhibits numerous characteristics, including HipBA and RelBE toxin-antitoxin systems, two major transfer (Tra) regions closely related to those of Salmonella enterica serovar plasmid pRH-R27, a type II restriction ..
  5. Shi H, Zhou X, Zou W, Wang Y, Lei C, Xiang R, et al. Co-occurrence of biofilm formation and quinolone resistance in Salmonella enterica serotype typhimurium carrying an IncHI2-type oqxAB-positive plasmid. Microb Pathog. 2018;123:68-73 pubmed publisher
    ..Typhimurium isolate from chicken farm was identified and sequenced, which contained oqxAB and tra/trh and encoded quinolone resistance and biofilms, and could be transferred to recipients through conjugation...
  6. Bakker J, Roubos S, Remarque E, Arndt S, Kronen P, Langermans J. Effects of buprenorphine, butorphanol or tramadol premedication on anaesthetic induction with alfaxalone in common marmosets (Callithrix jacchus). Vet Anaesth Analg. 2018;45:309-319 pubmed publisher
    ..2 mg kg-1 IM (BUT-A), tramadol 1.5 mg kg-1 IM (TRA-A) or no additional drug (control) were administered to all marmosets as premedication...
  7. Alvarez I, Collado J, Colobran R, Carrascal M, Ciudad M, Canals F, et al. Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome. J Autoimmun. 2015;60:12-9 pubmed publisher
    ..Within a large panel of peptides from abundant proteins, two TRA peptides were identified: prostate-specific semenogelin-1 (an autoantigen in autoimmune chronic prostatitis/chronic ..
  8. Pirahmadi S, Zakeri S, A Mehrizi A, D Djadid N, Raz A, J Sani J, et al. Cell-traversal protein for ookinetes and sporozoites (CelTOS) formulated with potent TLR adjuvants induces high-affinity antibodies that inhibit Plasmodium falciparum infection in Anopheles stephensi. Malar J. 2019;18:146 pubmed publisher
    ..However, immunological characteristic (IgG level, cytophilic IgG2a and IgG2b, avidity, and Th1 cytokines) and TRA of anti-rPfCelTOS significantly enhanced in the presence of co-administration of TLR-based adjuvants, confirming ..
  9. Chen L, He Z, Iuga A, Martins Filho S, Faith J, Clemente J, et al. Diet Modifies Colonic Microbiota and CD4+ T-Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-Cell Expression of Interleukin 23. Gastroenterology. 2018;155:1177-1191.e16 pubmed publisher
    ..We also performed studies with R23FR/Rag-/-, R23FR/Mu-/-, and R23FR/Tcrd-/- mice. R23FR mice were given injections of antibodies against CD4 or CD8 to deplete T cells...
  10. Luan N, Sharma N, Kim S, Ha P, Hong Y, Oh S, et al. Characterization and cardiac differentiation of chicken spermatogonial stem cells. Anim Reprod Sci. 2014;151:244-55 pubmed publisher germline cell specific (DAZL or VASA) and stage-specific embryonic antigens (Oct4, SSEA1, SSEA3, SSEA4, TRA-1-60, and TRA-1-81)...
  11. Occhionorelli S, La Manna A, Stano R, Morganti L, Vasquez G. The surgical approach to near-total small bowel infarction in a patient with massive portomesenteric thrombosis. Case report. Ann Ital Chir. 2016;87: pubmed
    ..circolazione mesenterica e di conseguenza un’ischemia intestinale; la trombosi venosa mesenterica è classificata tra le forme più rare e letali di ischemia mesenterica acuta, in quanto responsabile di un tasso di mortalità del 13-..
  12. Nashat M, Luchins K, Lepherd M, Riedel E, Izdebska J, Lipman N. Characterization of Demodex musculi Infestation, Associated Comorbidities, and Topographic Distribution in a Mouse Strain with Defective Adaptive Immunity. Comp Med. 2017;67:315-329 pubmed
    A colony of B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest (TRP1/TCR) mice presented with ocular lesions and ulcerative dermatitis. Histopathology, skin scrapes, and fur plucks confirmed the presence of Demodex spp...
  13. Rahman M, Spitzhorn L, Wruck W, Hagenbeck C, Balan P, Graffmann N, et al. The presence of human mesenchymal stem cells of renal origin in amniotic fluid increases with gestational time. Stem Cell Res Ther. 2018;9:113 pubmed publisher
    ..Regardless of the media used, AFCs showed expression of pluripotency-associated markers such as SSEA4, TRA-1-60, TRA-1-81 and C-Kit. They also express the mesenchymal marker Vimentin...
  14. Romano M, Festini F, Bronner L. [Cross-sectional study on the determinants of work stress for nurses and intention of leaving the profession]. Prof Inferm. 2015;68:203-10 pubmed publisher
    ..Gli obiettivi di questo studio sono dunque: stimare la prevalenza di stress tra gli infermieri di tre ospedali, in modo da disporre di dati epidemiologici per valutare la necessità di ..
  15. Zhang S, Li H, Ma L, Qian W, Wang Z, Wu Z. Urine-derived induced pluripotent stem cells as a modeling tool for paroxysmal kinesigenic dyskinesia. Biol Open. 2015;4:1744-52 pubmed publisher
    ..649dupC mutation (PKD-iPSCs). These cell lines were positive for alkaline phosphatase Nanog, Tra-1-80, Tra-1-60, SSEA-3 and SSEA-4...
  16. Cunico L, Fredo S, Bernini M. [The most cited themes in the research in the field of Mental Health: analyses of six international nursing and medical journals]. Prof Inferm. 2017;70:93-101 pubmed publisher
    ..Nella ricerca medica, gli antidepressivi sono i farmaci più studiati e tra le psicoterapie, la terapia cognitivo comportamentale...
  17. Choi K, Ortega M, Jeffery B, Riviere J, Monteiro Riviere N. Oxidative stress response in canine in vitro liver, kidney and intestinal models with seven potential dietary ingredients. Toxicol Lett. 2016;241:49-59 pubmed publisher
    ..DB and TRA showed strong prooxidant activities in hepatocytes and to a lesser degree in ELC. DB was a weak prooxidant in BMSC...
  18. Korbut R, Mehrdana F, Kania P, Larsen M, Frees D, Dalsgaard I, et al. Antigen Uptake during Different Life Stages of Zebrafish (Danio rerio) Using a GFP-Tagged Yersinia ruckeri. PLoS ONE. 2016;11:e0158968 pubmed publisher
    ..Larval, juvenile and adult transparent zebrafish (tra:nac mutant) received a bath in the bacterin for up to 30 minutes...
  19. Prado A, Favaron P, da Silva L, Baccarin R, Miglino M, Maria D. Characterization of mesenchymal stem cells derived from the equine synovial fluid and membrane. BMC Vet Res. 2015;11:281 pubmed publisher
    ..markers, and both lineages showed significant expression of CD45, Oct3/4, Nanog, CD105, CD90, CD34, CD117, CD133, TRA-1-81, VEGF, and LY6a...
  20. Reinhardt A, Yevsa T, Worbs T, Lienenklaus S, Sandrock I, Oberdörfer L, et al. Interleukin-23-Dependent ?/? T Cells Produce Interleukin-17 and Accumulate in the Enthesis, Aortic Valve, and Ciliary Body in Mice. Arthritis Rheumatol. 2016;68:2476-86 pubmed publisher
    ..We used 2-photon microscopy and flow cytometry to analyze entheseal lymphocytes from C57BL/6, Tcrd-H2BeGFP, Rorc-GFP, and IL-23R-eGFP mice...
  21. Soygur B, Moore H. Expression of Syncytin 1 (HERV-W), in the preimplantation human blastocyst, embryonic stem cells and trophoblast cells derived in vitro. Hum Reprod. 2016;31:1455-61 pubmed publisher
    ..expression of Syncytin 1 in cells on the periphery of the ICM also displaying pluripotency antibody marker (Tra-1-60). Three-dimensional reconstruction of confocal slice data provided good visualization of expression...
  22. Hernández García M, León Sampedro R, Pérez Viso B, Morosini M, López Fresneña N, Diaz Agero C, et al. First Report of an OXA-48- and CTX-M-213-Producing Kluyvera Species Clone Recovered from Patients Admitted in a University Hospital in Madrid, Spain. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..fragment length polymorphism [RFLP] analysis [DraI and HpaI], and PCR [incompatibility group and repA, traU, and parA genes])...
  23. Messina A, Casani A, Manfrin M, Guidetti G. Italian survey on benign paroxysmal positional vertigo. Acta Otorhinolaryngol Ital. 2017;37:328-335 pubmed publisher
    ..Frequentemente dopo il primo episodio la VPPB presenta recidive, con un tasso di ricorrenza tra il 15% ed il 50%...
  24. Kocael P, Simsek O, Saribeyoglu K, Pekmezci S, Goksoy E. Laparoscopic surgery in pregnant patients with acute abdomen. Ann Ital Chir. 2015;86:137-42 pubmed donne gestanti in caso di addome acuto analizzando retrospettivamente la casistica della pazienti ricoverate tra il gennaio 1995 ed il gennaio 2013 presso l’Emergency Department della Cerrahpasa Medical Faculty...
  25. Shi H, Fu Q, Li G, Ren Y, Hu S, Ni W, et al. Roles of p53 and ASF1A in the Reprogramming of Sheep Kidney Cells to Pluripotent Cells. Cell Reprogram. 2015;17:441-52 pubmed publisher
    ..cells (ESCs) and were positive for alkaline phosphatase and, pluripotent marker genes (Oct4, Nanog, Sox2, Rex1, TRA-1-60, TRA-1-81, and E-cadherin)...
  26. Nicodemi S, Corelli S, Sacchi M, Ricciardi E, Costantino A, Di Legge P, et al. Recurrent incisional hernia, enterocutaneous fistula and loss of the substance of the abdominal wall: plastic with organic prosthesis, skin graft and VAC therapy. Clinical case. Ann Ital Chir. 2015;86:172-6 pubmed severa, con un’incidenza descritta in letteratura tra 0.4% e 3.5%. Il tasso di mortalità riportato è superiore al 45% 1,2...
  27. Weiher H, Pircher H, Jansen Dürr P, Hegenbarth S, Knolle P, Grunau S, et al. A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells. BMC Res Notes. 2016;9:128 pubmed publisher
    ..Mutations in the yeast homolog Sym1, and in the zebra fish homolog tra cause interesting, but not obviously related phenotypes, although the human gene can complement the yeast Sym1 ..
  28. Steeden J, Pandya B, Tann O, Muthurangu V. Free breathing contrast-enhanced time-resolved magnetic resonance angiography in pediatric and adult congenital heart disease. J Cardiovasc Magn Reson. 2015;17:38 pubmed publisher
    ..A TRA sequence was developed by combining spiral trajectories with sensitivity encoding (SENSE, x4 kx-ky and x2 kz) and ..
  29. Ishida M, Kagawa S, Shimoyama K, Takehara K, Noma K, Tanabe S, et al. Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer. Mol Cancer Ther. 2016;15:402-11 pubmed publisher
    ..Trastuzumab-IR700 (Tra-IR700)-mediated PIT induced selective cell death of HER2-ECD-transduced tumor cells...
  30. Kolte D, Spence N, Puthawala M, Hyder O, Tuohy C, Davidson C, et al. Association of radial versus femoral access with contrast-induced acute kidney injury in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction. Cardiovasc Revasc Med. 2016;17:546-551 pubmed publisher
    ..Of 1162 patients who underwent primary PCI for STEMI, TFA was used in 857 (73.8%), and TRA in 305 (26.2%) patients...
  31. Geuverink E, Rensink A, Rondeel I, Beukeboom L, van de Zande L, Verhulst E. Maternal provision of transformer-2 is required for female development and embryo viability in the wasp Nasonia vitripennis. Insect Biochem Mol Biol. 2017;90:23-33 pubmed publisher
    ..Only a female-specifically spliced tra mRNA yields a functional TRA-protein that forms a complex with TRA2, encoded by a transformer-2 (tra2) ortholog, to ..
  32. Miragaia R, Zhang X, Gomes T, Svensson V, Ilicic T, Henriksson J, et al. Single-cell RNA-sequencing resolves self-antigen expression during mTEC development. Sci Rep. 2018;8:685 pubmed publisher
    ..Furthermore, expression patterns of TRA genes have been suggested to change over the course of mTEC development...
  33. Carvalho G, Poalas K, Demian C, Hatchi E, Vazquez A, Bidere N. Participation of the cell polarity protein PALS1 to T-cell receptor-mediated NF-?B activation. PLoS ONE. 2011;6:e18159 pubmed publisher
    ..The cell polarity protein PALS1 is expressed in T lymphocytes and participates to the optimal activation of NF-?B following TCR stimulation. ..
  34. Romay E, Ferrer R. Extracorporeal CO2 removal: Technical and physiological fundaments and principal indications. Med Intensiva. 2016;40:33-8 pubmed publisher
    ..More recently, the use of this technique has allowed the emergence of a relatively new concept called "tra-protective ventilation"whose effects are still to be determined...
  35. Alshali R, Salim N, Sung R, Satterthwaite J, Silikas N. Analysis of long-term monomer elution from bulk-fill and conventional resin-composites using high performance liquid chromatography. Dent Mater. 2015;31:1587-98 pubmed publisher
    ..Six bulk-fill (SureFil SDR, Venus Bulk Fill, X-tra base, Filtek Bulk Fill flowable, Sonic Fill, and Tetric EvoCeram Bulk Fill) and eight conventional resin-composites (..
  36. Posham R, Biederman D, Patel R, Kim E, Tabori N, Nowakowski F, et al. Transradial Approach for Noncoronary Interventions: A Single-Center Review of Safety and Feasibility in the First 1,500 Cases. J Vasc Interv Radiol. 2016;27:159-66 pubmed publisher
    ..Retrospective analysis was performed of 946 patients evaluated for 1,531 consecutive TRA procedures from April 2012 to July 2015...
  37. Pinto C, Reig Valero R, Iadeluca A, Lomuscio S, Caldarulo T, Sponton A. [Nursing role in prevention of Ventilator Associated Pneumonia: Spanish project "Neumonìa Zero"]. Prof Inferm. 2015;68:151-6 pubmed publisher
    ..L’incidenza dalla Polmonite Associata a Ventilazione meccanica invasiva (VAP) varia tra l’8 e il 28% dei pazienti in ventila- zione meccanica invasiva ed è associata ad elevati tassi di mortalit..
  38. Delia S. [Perché la legionellosi è una tra le più temibili ICA]. Clin Ter. 2017;168:e338-e339 pubmed publisher
    ..In ambito ospedaliero, che annovera questa patologia tra le più pericolose Infezioni Correlate all'Assistenza (ICA), si registrano decisamente i casi più gravi e assai ..
    ..Core stability is required for extremity movement and if the timing of when the TrA contracts is not corrected patients may continue to experience LBP.
  40. FAGAN K, Luo J, Lagoy R, Schroeder F, Albrecht D, Portman D. A Single-Neuron Chemosensory Switch Determines the Valence of a Sexually Dimorphic Sensory Behavior. Curr Biol. 2018;28:902-914.e5 pubmed publisher
    ..detects the ascaroside ascr#3 only in males, a consequence of cell-autonomous action of the master sexual regulator tra-1. This occurs in part through the conserved DM-domain gene mab-3, which promotes the male state of ADF...
  41. Arafat W, Zhou T, Naoum G, Buchsbaum D. Targeted radiotherapy potentiates the cytotoxicity of a novel anti-human DR5 monoclonal antibody and the adenovirus encoding soluble TRAIL in prostate cancer. J Egypt Natl Canc Inst. 2015;27:205-15 pubmed publisher
    ..We have developed a novel anti-human DR-5 monoclonal antibody (TRA-8) and adenoviral encoding TRAIL (Ad/TRAIL)...
  42. Lempel E, Czibulya Z, Kovacs B, Szalma J, Toth A, Kunsági Máté S, et al. Degree of Conversion and BisGMA, TEGDMA, UDMA Elution from Flowable Bulk Fill Composites. Int J Mol Sci. 2016;17: pubmed publisher
    ..Four millimeter-thick samples were prepared from SureFil SDR Flow (SDR), X-tra Base (XB), Filtek Bulk Fill (FBF) and two and four millimeter samples from Filtek Ultimate Flow (FUF)...
  43. Bourgin M, Borowska E, Helbing J, Hollender J, Kaiser H, Kienle C, et al. Effect of operational and water quality parameters on conventional ozonation and the advanced oxidation process O3/H2O2: Kinetics of micropollutant abatement, transformation product and bromate formation in a surface water. Water Res. 2017;122:234-245 pubmed publisher
    ..the evolution of the two main transformation products (TPs) of hydrochlorothiazide (HCTZ) and tramadol (TRA), chlorothiazide (CTZ) and tramadol N-oxide (TRA-NOX), respectively, was assessed by chemical analysis and kinetic ..
  44. Cunha A, Esteves M, das Neves S, Borges S, Guimarães M, Sousa N, et al. Pawedness Trait Test (PaTRaT)-A New Paradigm to Evaluate Paw Preference and Dexterity in Rats. Front Behav Neurosci. 2017;11:192 pubmed publisher
    ..We have therefore developed a semi-quantitative method-the pawdeness trait test (PaTRaT)-to evaluate paw preference degree in rats...
  45. Sokolov M, Panyutin I, Onyshchenko M, Panyutin I, Neumann R. Expression of pluripotency-associated genes in the surviving fraction of cultured human embryonic stem cells is not significantly affected by ionizing radiation. Gene. 2010;455:8-15 pubmed publisher
    ..expression of marker genes, associated with pluripotent state of hESC, such as Oct-4, Nanog, Sox-2, SSEA-4, TERT, TRA-1-60 and TRA-1-81 up to 65h after exposure to ionizing radiation (IR) using flow cytometry, immunocytochemistry and ..
  46. Ghosh K, Selokar N, Gahlawat S, Kumar D, Kumar P, Yadav P. Amnion Epithelial Cells of Buffalo (Bubalus Bubalis) Term Placenta Expressed Embryonic Stem Cells Markers and Differentiated into Cells of Neurogenic Lineage In Vitro. Anim Biotechnol. 2016;27:38-43 pubmed publisher
    ..Immunofluorescence staining with pluripotent stem cell surface markers, SSEA-1, SSEA-4, TRA-1-60, and TRA-1-81 indicated that these cells may retain pluripotent stem cell characteristics even after long ..
  47. Schmitz M, Baekelandt S, Tran Thi L, Mandiki S, Douxfils J, Nguyen T, et al. Osmoregulatory and immunological status of the pond-raised striped catfish (Pangasianodon hypophthalmus S.) as affected by seasonal runoff and salinity changes in the Mekong Delta, Vietnam. Fish Physiol Biochem. 2017;43:39-49 pubmed publisher
    ..out during the dry season 2013 (March-April) and rainy season 2014 (July-August) in 12 fish farms of the lower (Tra Vinh Province) and higher (Can Tho Province) Mekong River Delta...
  48. Bharathan S, Manian K, Aalam S, Palani D, Deshpande P, Pratheesh M, et al. Systematic evaluation of markers used for the identification of human induced pluripotent stem cells. Biol Open. 2017;6:100-108 pubmed publisher
    ..reprogramming for their morphological changes and expression of fibroblast (CD13), pluripotency markers (SSEA-4 and TRA-1-60) and a retrovirally expressed red fluorescent protein (RV-RFP), we compared the efficiency of these features ..
  49. van Andel L, Fudio S, Rosing H, Munt S, Miguel Lillo B, Gonzalez I, et al. Pharmacokinetics and excretion of 14C-Plitidepsin in patients with advanced cancer. Invest New Drugs. 2017;35:589-598 pubmed publisher
    ..Faeces, on the other hand contained low levels of parent compound, which means that most of the TRA excreted in faeces was accounted for by metabolites. TRA levels were 3...
  50. Schernthaner C, Hammerer M, Harb S, Heigert M, Hoellinger K, Lassnig E, et al. Radial versus femoral access site for percutaneous coronary intervention in patients suffering acute myocardial infarction : A randomized prospective multicenter trial. Wien Klin Wochenschr. 2018;130:182-189 pubmed publisher
    ..The aim of this study was to evaluate the impact of TRA versus TFA for PCI on clinically significant vascular access complications in the setting of acute myocardial ..
  51. Xuan L, Wu X, Wu M, Zhang Y, Liu H, Fan Z, et al. Effect of granulocyte colony-stimulating factor mobilization on the expression patterns, clonality and signal transduction of TRAV and TRBV repertoire. Immunobiology. 2012;217:816-22 pubmed publisher
    ..We found that G-CSF mobilization had an effect on the expression patterns, clonality and signal transduction of TRAV and TRBV repertoire. This alteration might play a role in mediating GVHD in G-CSF mobilized allo-PBSCT. ..
  52. De Caro W, Caranzetti M, Capriati I, Alicastro M, Angelini S, Dionisi S, et al. [The concept of Health Literacy and its importance for nursing]. Prof Inferm. 2015;68:133-42 pubmed publisher
    ..La salute degli individui e della popolazione dipende da una serie di variabili tra cui decisioni sociali, ambientali, economiche e culturali che mettono in connessione l’individuo con la ..
  53. Murray M, Lange B, Chreiteh S, Olsen H, Nørnberg B, Boyle E, et al. Neck and shoulder muscle activity and posture among helicopter pilots and crew-members during military helicopter flight. J Electromyogr Kinesiol. 2016;27:10-7 pubmed publisher
    ..Mean muscle activity for UNE was ∼10% MVE and significantly higher than TRA and SCM, and SCM was significantly lower than TRA. There was no significant difference between AB-NVG and AB+NVG...
  54. Furukawa J, Okada K, Shinohara Y. Glycomics of human embryonic stem cells and human induced pluripotent stem cells. Glycoconj J. 2016;33:707-15 pubmed publisher
    ..cell surface markers were discovered and identified as glycoconjugates such as stage-specific embryonic antigen, Tra-1-60/81 and various other cell surface molecules (e.g., cluster of differentiation)...
  55. McHugh L, Politi I, Al Fodeh R, Fleming G. Implications of resin-based composite (RBC) restoration on cuspal deflection and microleakage score in molar teeth: Placement protocol and restorative material. Dent Mater. 2017;33:e329-e335 pubmed publisher
    ..001) while the Admira Fusion x-tra (bonded) bulk fill resin restored teeth had significantly the lowest microleakage scores compared with Tetric ..
  56. Faingold O, Cohen T, Shai Y. A GxxxG-like motif within HIV-1 fusion peptide is critical to its immunosuppressant activity, structure, and interaction with the transmembrane domain of the T-cell receptor. J Biol Chem. 2012;287:33503-11 pubmed
    ..Overall, the data support an important role for the AxxxG motif in the function of FP and might explain the natural selection of the AxxxG motif rather than the classical GxxxG motif in FP. ..
  57. Fuchs T, Puellmann K, Emmert A, Fleig J, Oniga S, Laird R, et al. The macrophage-TCRαβ is a cholesterol-responsive combinatorial immune receptor and implicated in atherosclerosis. Biochem Biophys Res Commun. 2015;456:59-65 pubmed publisher
  58. Liu G, Wu Q, Li J, Zhang G, Wan F. RNAi-Mediated Knock-Down of transformer and transformer 2 to Generate Male-Only Progeny in the Oriental Fruit Fly, Bactrocera dorsalis (Hendel). PLoS ONE. 2015;10:e0128892 pubmed publisher
    ..In this study, we describe the isolation, expression and function of tra and tra-2 in the economically important agricultural pest, the oriental fruit fly, Bactrocera dorsalis (Hendel)...
  59. Fischman A, Swinburne N, Patel R. A Technical Guide Describing the Use of Transradial Access Technique for Endovascular Interventions. Tech Vasc Interv Radiol. 2015;18:58-65 pubmed publisher
    ..However, TRA remains underused by the interventional radiology and vascular surgery communities...
  60. Davies P, Grace F, Lewis M, Sculthorpe N. Observation of Age-Related Decline in the Performance of the Transverse Abdominis Muscle. PM R. 2016;8:45-50 pubmed publisher
    ..To assess the effect of age on TrA activation in response to rapid arm abduction. Cross-sectional cohort study...
  61. Comparcini D, Simonetti V, Lupo R, Cicolini G. [Nurses' experiences of stalking: a narrative review]. Prof Inferm. 2015;68:174-82 pubmed publisher
    ..attraverso Pubmed), CINHAL e il motore di ricerca Google Scholar limitando la ricerca agli studi pubblicati tra il 1999 e il 2013, in lingua inglese ed italiana...
  62. Stolker J, Hadid M, Hussain Z, Rough S, Ibrahim M, Kennedy K, et al. Training the next generation of invasive cardiologists: Feasibility of implementing a trans-radial access program at an academic hospital. Cardiovasc Revasc Med. 2016;17:431-437 pubmed publisher
    ..S. may be related to concerns about procedural complexity and a steep learning curve. However, TRA acceptance among novice operators remains poorly characterized...
  63. Liu Z, Zhao R. Generation of HEXA-deficient hiPSCs from fibroblasts of a Tay-Sachs disease patient. Stem Cell Res. 2016;17:289-291 pubmed publisher
    ..TSD-01-hiPSC express pluripotency markers such as OCT4, SOX2, NANOG, Tra-1-60, and alkaline phosphatase, and can differentiate into tissues from all the three embryonic germ layers...
  64. Franco F, Silva E, Barrios Leal D, Sene F, Manfrin M. The Calibrated Phylogeny of the Drosophila fasciola Subgroup (D. repleta Group Wasserman) Indicates Neogene Diversification of Its Internal Branches. Neotrop Entomol. 2017;46:537-545 pubmed publisher
    ..cytochrome oxidase subunit II (COII)] and two nuclear [elongation factor-1alpha F1 (EF-alphaF1) and transformer (tra)] genes...
  65. Bryniarski L, Zabojszcz M, Bryniarski K. Treatment of coronary chronic total occlusion by transradial approach: Current trends and expert recommendations. Cardiol J. 2017;24:695-699 pubmed publisher
    ..on percutaneous coronary interventions (PCIs) in chronic total occlusion (CTO) performed by transradial approach (TRA)...
  66. Akbari M, Sarrafzadeh J, Maroufi N, Haghani H. Changes in postural and trunk muscles responses in patients with chronic nonspecific low back pain during sudden upper limb loading. Med J Islam Repub Iran. 2015;29:265 pubmed
    ..Electromyography of the erector spinae (ES) and transverses abdominis/internal oblique (TrA/IO) and external oblique (EOA) muscles were recorded in 20 patients with CLBP and 20 asymptomatic individuals with ..
  67. Mamas M, Nolan J, de Belder M, Zaman A, Kinnaird T, Curzen N, et al. Changes in Arterial Access Site and Association With Mortality in the United Kingdom: Observations From a National Percutaneous Coronary Intervention Database. Circulation. 2016;133:1655-67 pubmed publisher
    ..United Kingdom, with randomized trials and national registry data showing reductions in mortality associated with TRA use...
  68. Carico Z, Roy Choudhury K, Zhang B, Zhuang Y, Krangel M. Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire. Cell Rep. 2017;19:2157-2173 pubmed publisher
    ..Here, we define the principles by which combinatorial diversity is generated in the murine Tcra repertoire...
  69. Schmitt T, Aggen D, Ishida Tsubota K, Ochsenreither S, Kranz D, Greenberg P. Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor T cells in vitro. Nat Biotechnol. 2017;: pubmed publisher
    ..In vitro differentiation of progenitors transduced with a known Tcra gene in the presence of antigen drives differentiation of cells with a distinct agonist-selected phenotype...
  70. Guan Z, Cheng W, Huang D, Wei A. High MYBL2 expression and transcription regulatory activity is associated with poor overall survival in patients with hepatocellular carcinoma. Curr Res Transl Med. 2018;66:27-32 pubmed publisher
    ..High B-Myb TRA was associated with poor OS (P=0.013)...
  71. Zhang W, Wang J, Li P, Wu C, Zhang H, Zhang W, et al. Transferrin-navigation Nano Artificial Antibody Fluorescence Recognition of Circulating Tumor Cells. Sci Rep. 2017;7:10142 pubmed publisher
    ..Take advantage of the specific interaction between TRA and TRA receptor (overexpressed on cancer cells), the as-prepared TRA-imprinted artificial antibody was allowed for ..
  72. Roberts J, Niu J. A novel technique for simultaneous hemostasis of ipsilateral radial and ulnar artery access sites. Catheter Cardiovasc Interv. 2017;: pubmed publisher
    ..access (TRA) for diagnostic and coronary interventional procedures, crossover to the ipsilateral ulnar artery after TRA failure is being reported more frequently...
  73. Carrasco Y, Navarro M, Toribio M. A role for the cytoplasmic tail of the pre-T cell receptor (TCR) alpha chain in promoting constitutive internalization and degradation of the pre-TCR. J Biol Chem. 2003;278:14507-13 pubmed
    ..These data suggest that constitutive pre-TCR down-modulation regulates pre-TCR surface expression levels and hence the extent of ligand-independent signaling through the pre-TCR. ..
  74. Navarro M, Nusspaumer G, Fuentes P, Gonzalez Garcia S, Alcain J, Toribio M. Identification of CMS as a cytosolic adaptor of the human pTalpha chain involved in pre-TCR function. Blood. 2007;110:4331-40 pubmed
    ..These results provide the first molecular evidence for a pTalpha intracellular adaptor involved in pre-TCR function. ..
  75. Ishikura S, Weissman A, Bonifacino J. Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulum-associated degradation of the unassembled protein. J Biol Chem. 2010;285:23916-24 pubmed publisher
    ..We also found that this ubiquitination was mediated by the ER-localized ubiquitin ligase, HRD1. These findings indicate that serine-dependent, HRD1-mediated ubiquitination targets TCRalpha to the ERAD pathway. ..
  76. Singh Y, Ferreira C, Chan A, Dyson J, Garden O. Restricted TCR-alpha CDR3 diversity disadvantages natural regulatory T cell development in the B6.2.16 beta-chain transgenic mouse. J Immunol. 2010;185:3408-16 pubmed publisher
  77. Belikov A, Schraven B, Simeoni L. TCR-triggered extracellular superoxide production is not required for T-cell activation. Cell Commun Signal. 2014;12:50 pubmed publisher
    ..However, superoxide is not required for T-cell activation, proliferation and cytokine production. ..
  78. Rigamonti F, Gencer B, Rey F, Chaara J, Tessitore E, Bunwaree S, et al. Pre-hospital alarm activation for STEMI patients undergoing primary percutaneous coronary intervention in the era of transradial procedures. Eur J Intern Med. 2016;35:83-88 pubmed publisher
    ..b>TRA was used in 85% of patients. We assessed how PHAS (n=165) vs...
  79. Merkle P, Irving M, Hongjian S, Ferber M, Jørgensen T, Scholten K, et al. The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed ?2-Microglobulin through Distinct Binding Sites. Biochemistry. 2017;56:3945-3961 pubmed publisher
  80. Usen A, Kuran B, Yilmaz F, Aksu N, Ercalik C. Evaluation of the internal oblique, external oblique, and transversus abdominalis muscles in patients with ankylosing spondylitis: an ultrasonographic study. Clin Rheumatol. 2017;36:2497-2500 pubmed publisher
    ..005). When the AS patients were classified according to the IPAQ scores, thicknesses of the IO and TrA muscles were significantly lower in patients who had the low level of IPAQ scores (p < 0.05)...
  81. Møller T, Liu G, Boysen A, Thomsen L, Lüthje F, Mortensen S, et al. Treatment with Cefotaxime Affects Expression of Conjugation Associated Proteins and Conjugation Transfer Frequency of an IncI1 Plasmid in Escherichia coli. Front Microbiol. 2017;8:2365 pubmed publisher
    ..Analysis of the proteome by iTRAQ labeling and liquid chromatography tandem mass spectrometry revealed that Tra proteins were significantly up-regulated in the presence of CTX...
  82. Fazilleau N, Bachelez H, Gougeon M, Viguier M. Cutting edge: size and diversity of CD4+CD25high Foxp3+ regulatory T cell repertoire in humans: evidence for similarities and partial overlapping with CD4+CD25- T cells. J Immunol. 2007;179:3412-6 pubmed
    ..These data emphasize the intersection between naturally occurring Treg and effector T cell peripheral repertoires and provide new insights into the ontogeny of Treg in humans. ..
  83. Miyagawa T, Honda M, Kawashima M, Shimada M, Tanaka S, Honda Y, et al. Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype. J Hum Genet. 2010;55:63-5 pubmed publisher
    ..Single-nucleotide polymorphism (SNP) rs1154155 located in the T-cell receptor alpha (TCRA) locus has been recently identified as a novel genetic marker of susceptibility for narcolepsy with cataplexy...
  84. Orlando L, Accomasso L, Circosta P, Turinetto V, Lantelme E, Porcedda P, et al. TCR transfer induces TCR-mediated tonic inhibition of RAG genes in human T cells. Mol Immunol. 2011;48:1369-76 pubmed publisher
    ..Lastly, we show that the TCR constructs employed in TCR gene therapy do not possess the same basal signaling transduction capability, a feature that may have therapeutic implications. ..
  85. Menon M, Tiedje C, Lafera J, Ronkina N, Konen T, Kotlyarov A, et al. Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNF? production. Biochem J. 2013;456:163-72 pubmed publisher
    ..Interestingly, Ube2j1 is phosphorylated in response to LPS also in macrophages and contributes to MK2-dependent TNF? biosynthesis by a so far unknown mechanism. ..
  86. Rådestad E, Wikell H, Engström M, Watz E, Sundberg B, Thunberg S, et al. Alpha/beta T-cell depleted grafts as an immunological booster to treat graft failure after hematopoietic stem cell transplantation with HLA-matched related and unrelated donors. J Immunol Res. 2014;2014:578741 pubmed publisher
    ..No signs of GVHD or other side effects were detected. A larger pool of patients with longer follow-up time is needed to confirm the data in this study. ..
  87. Lorenzoni R, Lisi C, Lorenzoni G, Tessandori L, Bovenzi F. Endovascular treatment of iliac and common femoral arteries disease by the transradial access: A prospective, feasibility study. Cardiovasc Revasc Med. 2018;19:314-318 pubmed publisher
    ..b>TRA can be used to treat iliac and common femoral arteries lesions with a high grade of technical success and a low rate ..
  88. Cui M, Zhang J, Zhang C, Li R, Wai Chi Chan E, Wu C, et al. Distinct mechanisms of acquisition of mcr-1 -bearing plasmid by Salmonella strains recovered from animals and food samples. Sci Rep. 2017;7:13199 pubmed publisher
    ..The lack of a region carrying the tra genes was found to account for the inability to undergo conjugation for various sizes of IncHI2 plasmids harbored by ..
  89. Soriano J, de Cid R, Estivill X, Anto J, Sunyer J, Otero D, et al. Association study of proposed candidate genes/regions in a population of Spanish asthmatics. Eur J Epidemiol. 2000;16:745-50 pubmed
    ..No association could be observed in this sample of Spanish asthmatics with the genes/regions studied. ..
  90. Cattaneo M, Otsu M, Fagioli C, Martino S, Lotti L, Sitia R, et al. SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains. J Cell Physiol. 2008;215:794-802 pubmed publisher
    ..These findings reveal a role for SEL1L and HRD1 in IgM quality control. ..
  91. Pierce B, Haidar J, Yu Y, Weng Z. Combinations of affinity-enhancing mutations in a T cell receptor reveal highly nonadditive effects within and between complementarity determining regions and chains. Biochemistry. 2010;49:7050-9 pubmed publisher
    ..These results highlight the complex nature of TCR association and binding and will be informative in future design efforts that combine multiple mutant residues. ..
  92. Warnecke N, Poltorak M, Kowtharapu B, Arndt B, Stone J, Schraven B, et al. TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells. EMBO Rep. 2012;13:386-91 pubmed publisher
    ..Thus, RasGRP1 and Grb2/Sos are insulators of signals that lead to Ras activation induced by different stimuli, rather than cooperating downstream of the TCR. ..