TPT1

Summary

Gene Symbol: TPT1
Description: tumor protein, translationally-controlled 1
Alias: HRF, TCTP, p02, p23, translationally-controlled tumor protein, fortilin, histamine-releasing factor
Species: human
Products:     TPT1

Top Publications

  1. MacDonald S, Rafnar T, Langdon J, Lichtenstein L. Molecular identification of an IgE-dependent histamine-releasing factor. Science. 1995;269:688-90 pubmed
    An immunoglobulin E (IgE)-dependent histamine-releasing factor (HRF) produced by lymphocytes of atopic children and present in biological fluids of allergic patients has been identified and purified...
  2. Zhang J, De Toledo S, Pandey B, Guo G, Pain D, Li H, et al. Role of the translationally controlled tumor protein in DNA damage sensing and repair. Proc Natl Acad Sci U S A. 2012;109:E926-33 pubmed publisher
    The translationally controlled tumor protein (TCTP) is essential for survival by mechanisms that as yet are incompletely defined. Here we describe an important role of TCTP in response to DNA damage...
  3. Choi S, Min H, Kim M, Hwang E, Lee K. Proton pump inhibitors exert anti-allergic effects by reducing TCTP secretion. PLoS ONE. 2009;4:e5732 pubmed publisher
    Extracellular translationally controlled tumor protein (TCTP) is known to play a role in human allergic responses...
  4. Gnanasekar M, Thirugnanam S, Zheng G, Chen A, Ramaswamy K. Gene silencing of translationally controlled tumor protein (TCTP) by siRNA inhibits cell growth and induces apoptosis of human prostate cancer cells. Int J Oncol. 2009;34:1241-6 pubmed
    b>Translationally controlled tumor protein (TCTP) is a novel anti apoptotic protein which is highly expressed in several cancer cell types including prostate cancer...
  5. Sanchez J, Schaller D, Ravier F, Golaz O, Jaccoud S, Belet M, et al. Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. Electrophoresis. 1997;18:150-5 pubmed
    The translationally controlled tumor protein (TCTP) is a growth-related protein which is regulated at the translational level. It is present in mammals, higher plants and Saccharomyces cerevisiae...
  6. Gnanasekar M, Dakshinamoorthy G, Ramaswamy K. Translationally controlled tumor protein is a novel heat shock protein with chaperone-like activity. Biochem Biophys Res Commun. 2009;386:333-7 pubmed publisher
    b>Translationally controlled tumor protein (TCTP) is often designated as a stress-related protein because of its highly regulated expression in stress conditions...
  7. Wang X, Fonseca B, Tang H, Liu R, Elia A, Clemens M, et al. Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem. 2008;283:30482-92 pubmed publisher
    ..Furthermore, FKBP38 did not inhibit mTORC1 signaling. The translationally controlled tumor protein (TCTP) in Drosophila was recently reported to act as the guanine nucleotide-exchange factor for ..
  8. Susini L, Besse S, Duflaut D, Lespagnol A, Beekman C, Fiucci G, et al. TCTP protects from apoptotic cell death by antagonizing bax function. Cell Death Differ. 2008;15:1211-20 pubmed publisher
    b>Translationally controlled tumor protein (TCTP) is a potential target for cancer therapy...
  9. Vonakis B, Macglashan D, Vilariño N, Langdon J, Scott R, MacDonald S. Distinct characteristics of signal transduction events by histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced priming and activation of human basophils. Blood. 2008;111:1789-96 pubmed
    ..identified a negative correlation between histamine release to histamine releasing factor/translationally controlled tumor protein (HRF/TCTP) and protein levels of the Src homology 2 domain-containing inositol 5' phosphatase (..

More Information

Publications84

  1. Hsu Y, Chern J, Cai Y, Liu M, Choi K. Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. Nature. 2007;445:785-8 pubmed
    ..Here we show that a conserved protein, translationally controlled tumour protein (TCTP), is an essential new component of the TSC-Rheb pathway...
  2. Arcuri F, Papa S, Meini A, Carducci A, Romagnoli R, Bianchi L, et al. The translationally controlled tumor protein is a novel calcium binding protein of the human placenta and regulates calcium handling in trophoblast cells. Biol Reprod. 2005;73:745-51 pubmed
    The translationally controlled tumor protein (TPT1, also known as TCTP) is a highly conserved, abundantly expressed protein found in mammals as well as in a wide range of other organisms of both the animal and plant kingdom...
  3. Jung J, Kim M, Kim M, Kim J, Moon J, Lim J, et al. Translationally controlled tumor protein interacts with the third cytoplasmic domain of Na,K-ATPase alpha subunit and inhibits the pump activity in HeLa cells. J Biol Chem. 2004;279:49868-75 pubmed
    b>Translationally controlled tumor protein (TCTP) is a growth-related protein under transcriptional as well as translational control...
  4. Vonakis B, Sora R, Langdon J, Casolaro V, MacDonald S. Inhibition of cytokine gene transcription by the human recombinant histamine-releasing factor in human T lymphocytes. J Immunol. 2003;171:3742-50 pubmed
  5. Zhang D, Li F, Weidner D, Mnjoyan Z, Fujise K. Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and Fortilin. The potential role of MCL1 as a fortilin chaperone. J Biol Chem. 2002;277:37430-8 pubmed
    ..Here, we report the identification of fortilin as a novel MCL1-interacting protein by screening of a yeast two-hybrid library with MCL1 as bait...
  6. Chen Y, Fujita T, Zhang D, Doan H, Pinkaew D, Liu Z, et al. Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic protein. J Biol Chem. 2011;286:32575-85 pubmed publisher
    ..b>Fortilin, a 172-amino acid polypeptide with potent anti-apoptotic activity, is up-regulated in many human malignancies...
  7. Graidist P, Phongdara A, Fujise K. Antiapoptotic protein partners fortilin and MCL1 independently protect cells from 5-fluorouracil-induced cytotoxicity. J Biol Chem. 2004;279:40868-75 pubmed
    b>Fortilin, a potent 172-amino acid antiapoptotic polypeptide (Li, F., Zhang, D., and Fujise, K. (2001) J. Biol. Chem. 276, 47542-47549), binds MCL1, a protein of the antiapoptotic Bcl-2 family...
  8. Rho S, Lee J, Park M, Byun H, Kang S, Seo S, et al. Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53. FEBS Lett. 2011;585:29-35 pubmed publisher
    In this study, we identified p53 as a novel TCTP-interacting protein using TCTP as bait. Also, we determined the critical binding sites between TCTP and p53...
  9. Yoneda K, Rokutan K, Nakamura Y, Yanagawa H, Kondo Teshima S, Sone S. Stimulation of human bronchial epithelial cells by IgE-dependent histamine-releasing factor. Am J Physiol Lung Cell Mol Physiol. 2004;286:L174-81 pubmed
    An IgE-dependent histamine-releasing factor (HRF p23; also known as translationally controlled tumor protein or p23) stimulates the release of histamine, IL-4, and IL-13 from a subpopulation of highly allergic donor basophils...
  10. Miao X, Chen Y, Xu S, Zhao T, Liu J, Li Y, et al. TCTP overexpression is associated with the development and progression of glioma. Tumour Biol. 2013;34:3357-61 pubmed publisher
    Upregulation of translationally controlled tumor protein (TCTP) has been reported in a variety of malignant tumors. However, the impact of TCTP in glioma remains unclear...
  11. Dong X, Yang B, Li Y, Zhong C, Ding J. Molecular basis of the acceleration of the GDP-GTP exchange of human ras homolog enriched in brain by human translationally controlled tumor protein. J Biol Chem. 2009;284:23754-64 pubmed publisher
    ..The GDP-GTP exchange of Rheb has been suggested to be facilitated by translationally controlled tumor protein (TCTP)...
  12. Yarm F. Plk phosphorylation regulates the microtubule-stabilizing protein TCTP. Mol Cell Biol. 2002;22:6209-21 pubmed
    ..protein, the mammalian non-MAP microtubule-binding and -stabilizing protein, the translationally controlled tumor protein (TCTP), was identified as a putative Plk-interacting clone by a two-hybrid screen...
  13. Amson R, Pece S, Lespagnol A, Vyas R, Mazzarol G, Tosoni D, et al. Reciprocal repression between P53 and TCTP. Nat Med. 2011;18:91-9 pubmed publisher
    ..for genes that reprogram cancer cells for the tumor reversion switch identified TCTP (encoding translationally controlled tumor protein) as a crucial regulator of apoptosis...
  14. Bommer U, Borovjagin A, Greagg M, Jeffrey I, Russell P, Laing K, et al. The mRNA of the translationally controlled tumor protein P23/TCTP is a highly structured RNA, which activates the dsRNA-dependent protein kinase PKR. RNA. 2002;8:478-96 pubmed
    ..Two out of five cDNA clones we obtained contained sequences derived from the mRNA of the translationally controlled tumor protein P23/TCTP, indicating that this mRNA is present in the dsRNA-rich fraction...
  15. Lucibello M, Gambacurta A, Zonfrillo M, Pierimarchi P, Serafino A, Rasi G, et al. TCTP is a critical survival factor that protects cancer cells from oxidative stress-induced cell-death. Exp Cell Res. 2011;317:2479-89 pubmed publisher
    The translationally controlled tumor protein (TCTP) displays growth-promoting and antiapoptotic properties...
  16. Jung J, Kim H, Sohn K, Kim M, Lee K. Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src. Oncogene. 2011;30:2264-74 pubmed publisher
    b>Translationally controlled tumor protein (TCTP) is implicated in cell growth and malignant transformation...
  17. Sirois I, Raymond M, Brassard N, Cailhier J, Fedjaev M, Hamelin K, et al. Caspase-3-dependent export of TCTP: a novel pathway for antiapoptotic intercellular communication. Cell Death Differ. 2011;18:549-62 pubmed publisher
    ..Tumor susceptibility gene 101 and translationally controlled tumor protein (TCTP) were identified in nanovesicle fractions purified from medium conditioned by apoptotic EC ..
  18. Ma Q, Geng Y, Xu W, Wu Y, He F, Shu W, et al. The role of translationally controlled tumor protein in tumor growth and metastasis of colon adenocarcinoma cells. J Proteome Res. 2010;9:40-9 pubmed publisher
    b>Translationally controlled tumor protein (TCTP) plays a major role in a broad array of biological processes. However, the TCTP-related biological process and interactive proteins still remain poorly characterized...
  19. Yoon T, Jung J, Kim M, Lee K, Choi E, Lee K. Identification of the self-interaction of rat TCTP/IgE-dependent histamine-releasing factor using yeast two-hybrid system. Arch Biochem Biophys. 2000;384:379-82 pubmed
    To further understand the biological function of translationally controlled tumor protein (TCTP), also known as IgE-dependent histamine-releasing factor (HRF), the yeast two-hybrid system was used to screen interacting molecules...
  20. Li F, Zhang D, Fujise K. Characterization of fortilin, a novel antiapoptotic protein. J Biol Chem. 2001;276:47542-9 pubmed
    ..We report here the characterization of novel antiapoptotic protein, fortilin, which we identified through yeast two-hybrid library screening...
  21. Chan T, Chen L, Liu M, Hu L, Zheng B, Poon V, et al. Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. Hepatology. 2012;55:491-505 pubmed publisher
    ..underlying HCC cases carrying CHD1L amplification (>50% HCCs), we identified a CHD1L target, translationally controlled tumor protein (TCTP), and investigated its role in HCC progression...
  22. Tuynder M, Susini L, Prieur S, Besse S, Fiucci G, Amson R, et al. Biological models and genes of tumor reversion: cellular reprogramming through tpt1/TCTP and SIAH-1. Proc Natl Acad Sci U S A. 2002;99:14976-81 pubmed
    ..b>Translationally Controlled Tumor Protein (tpt1/TCTP) has the strongest differential expression, down-regulated in the reversion of U937- ..
  23. Feng Y, Liu D, Yao H, Wang J. Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR. Arch Biochem Biophys. 2007;467:48-57 pubmed
    Human translationally controlled tumor protein (TCTP) is a growth-related, calcium-binding protein...
  24. Yang Y, Yang F, Xiong Z, Yan Y, Wang X, Nishino M, et al. An N-terminal region of translationally controlled tumor protein is required for its antiapoptotic activity. Oncogene. 2005;24:4778-88 pubmed
    ..We have identified translationally controlled tumor protein (TCTP), a multifunctional protein, as a novel antiapoptotic Bcl-xL-interacting protein...
  25. Cans C, Passer B, Shalak V, Nancy Portebois V, Crible V, Amzallag N, et al. Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation factor eEF1A. Proc Natl Acad Sci U S A. 2003;100:13892-7 pubmed
    Recently, we demonstrated that the expression levels of the translationally controlled tumor protein (TCTP) were strongly down-regulated at the mRNA and protein levels during tumor reversion/suppression and by the activation of p53 and ..
  26. Amzallag N, Passer B, Allanic D, Segura E, Thery C, Goud B, et al. TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. J Biol Chem. 2004;279:46104-12 pubmed
    b>Translationally controlled tumor protein (TCTP) is cytoplasmic and structurally related to guanine-nucleotide free chaperones...
  27. Arcuri F, Papa S, Carducci A, Romagnoli R, Liberatori S, Riparbelli M, et al. Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: expression, distribution, and calcium binding activity. Prostate. 2004;60:130-40 pubmed
    The translationally controlled tumor protein (TCTP) is an abundantly expressed protein found in a wide range of organisms from both the animal and plant kingdom...
  28. Jeon H, You S, Park Y, Chang J, Kim J, Oh J. TCTP regulates spindle microtubule dynamics by stabilizing polar microtubules during mouse oocyte meiosis. Biochim Biophys Acta. 2016;1863:630-7 pubmed publisher
    ..Here, we show that translationally controlled tumor protein (TCTP) is a novel microtubule-associated protein that regulates spindle dynamics during meiotic ..
  29. Chattopadhyay A, Pinkaew D, Doan H, Jacob R, Verma S, Friedman H, et al. Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice. Sci Rep. 2016;6:18701 pubmed publisher
    b>Fortilin, a pro-survival molecule, inhibits p53-induced apoptosis by binding to the sequence-specific DNA-binding domain of the tumor suppressor protein and preventing it from transcriptionally activating Bax...
  30. Abdulrahman H, Henson R. Effect of trial-to-trial variability on optimal event-related fMRI design: Implications for Beta-series correlation and multi-voxel pattern analysis. Neuroimage. 2016;125:756-766 pubmed publisher
    ..from a General Linear Model (GLM) in which trial onsets are convolved with a Hemodynamic Response Function (HRF)...
  31. Seo J, Maeng J, Kim H. Translationally Controlled Tumor Protein Stimulates Dopamine Release from PC12 Cells via Ca2+-Independent Phospholipase A? Pathways. Int J Mol Sci. 2016;17: pubmed
    The translationally controlled tumor protein (TCTP), initially identified as a tumor- and growth-related protein, is also known as a histamine-releasing factor (HRF)...
  32. Ben Said R, Hamed A, Mahalel U, Al Ayed A, Kowalczyk M, Moldoch J, et al. Tentative Characterization of Polyphenolic Compounds in the Male Flowers of Phoenix dactylifera by Liquid Chromatography Coupled with Mass Spectrometry and DFT. Int J Mol Sci. 2017;18: pubmed publisher
    ..of B-type proanthocyanidins were based on the diagnostic ions resulting from heterocyclic ring fission (HRF) and retro-Diels-Alder (RDA) reaction of flavan-3-ol provided information on the hydroxylation pattern and the type ..
  33. Lackey L, Coria A, Woods C, McArthur E, Laederach A. Allele-specific SHAPE-MaP assessment of the effects of somatic variation and protein binding on mRNA structure. RNA. 2018;24:513-528 pubmed publisher
    ..a rapid, comprehensive survey of noncoding somatic and inherited riboSNitches in two cancer-associated mRNAs, TPT1 and LCP1 Using rigorous thermodynamic modeling of the Boltzmann suboptimal ensemble, we identified a ..
  34. Tachibana A, Hamajima R, Tomizaki M, Kondo T, Nanba Y, Kobayashi M, et al. HCF-1 encoded by baculovirus AcMNPV is required for productive nucleopolyhedrovirus infection of non-permissive Tn368 cells. Sci Rep. 2017;7:3807 pubmed publisher
    ..Taken together with the previous findings on HRF-1 (host range factor 1), the present results provide strong evidence that viral genes acquired through horizontal ..
  35. Du B, Wei Z, Wang Z, Wang X, Peng X, Du B, et al. Phloem-exudate proteome analysis of response to insect brown plant-hopper in rice. J Plant Physiol. 2015;183:13-22 pubmed publisher
    ..The mRNAs for three proteins, RGAP, TCTP, and TRXH, were further analyzed by using in situ mRNA hybridization and localized in the phloem cells...
  36. Lo W, Wang H, Chiu C, Chen S. miR-27b-regulated TCTP as a novel plasma biomarker for oral cancer: from quantitative proteomics to post-transcriptional study. J Proteomics. 2012;77:154-66 pubmed publisher
    ..After preliminary screening, EGFR, OAT, TPT1, ITGA6, G3BP1 and CB39L were the six genes validated in the 37 oral cancer patients (T1, n=10; T2, n=10; T3, n=10 ..
  37. Kim J, Ress D. Reliability of the depth-dependent high-resolution BOLD hemodynamic response in human visual cortex and vicinity. Magn Reson Imaging. 2017;39:53-63 pubmed publisher
    Functional magnetic resonance imaging (fMRI) often relies on a hemodynamic response function (HRF), the stereotypical blood oxygen level dependent (BOLD) response elicited by a brief (<4s) stimulus...
  38. Katsogiannou M, Andrieu C, Baylot V, Baudot A, Dusetti N, Gayet O, et al. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Mol Cell Proteomics. 2014;13:3585-601 pubmed publisher
    ..As an example, we showed that targeting Hsp27 interaction with TCTP, a partner protein identified in our screen increases therapy sensitivity, opening a new promising field of ..
  39. Zhang J, Shim G, De Toledo S, Azzam E. The Translationally Controlled Tumor Protein and the Cellular Response to Ionizing Radiation-Induced DNA Damage. Results Probl Cell Differ. 2017;64:227-253 pubmed publisher
    ..insight into the mechanisms underlying these effects, we observed a prominent upregulation of the Translationally Controlled Tumor Protein (TCTP) in low dose/low dose rate 137Cs γ-irradiated cells that was associated with ..
  40. Rollings D, Assecondi S, Ostwald D, Porcaro C, McCorry D, Bagary M, et al. Early haemodynamic changes observed in patients with epilepsy, in a visual experiment and in simulations. Clin Neurophysiol. 2016;127:245-253 pubmed publisher
    ..The visual dataset and simulations demonstrated an overlap between modelled haemodynamic response function (HRF) at event onset and at ± 3 s relative to onset, which diminished at ± 6s...
  41. Williams R, Goodyear B, Peca S, McCreary C, Frayne R, Smith E, et al. Identification of neurovascular changes associated with cerebral amyloid angiopathy from subject-specific hemodynamic response functions. J Cereb Blood Flow Metab. 2017;37:3433-3445 pubmed publisher
    ..however, it is unknown whether such perturbations are associated with changes in the hemodynamic response function (HRF)...
  42. Liu X, Gerraty R, Grinband J, Parker D, Razlighi Q. Brain atrophy can introduce age-related differences in BOLD response. Hum Brain Mapp. 2017;: pubmed publisher
    ..e., hemodynamic impulse response function (HRF)). Such uncertainty introduces a significant challenge in the interpretation of the fMRI results...
  43. Lucibello M, Adanti S, Antelmi E, Dezi D, Ciafrè S, Carcangiu M, et al. Phospho-TCTP as a therapeutic target of Dihydroartemisinin for aggressive breast cancer cells. Oncotarget. 2015;6:5275-91 pubmed
    Upregulation of Translationally Controlled Tumor Protein (TCTP) is associated with poorly differentiated aggressive tumors, including breast cancer, but the underlying mechanism(s) are still debated...
  44. Shu Y, Zhang Y, Cheng M, Zeng H, Wang J. Multilevel assessment of Cry1Ab Bt-maize straw return affecting the earthworm Eisenia fetida. Chemosphere. 2015;137:59-69 pubmed publisher
    ..Translationally controlled tumour protein (TCTP) and superoxide dismutase (SOD) genes were down-regulated, while annetocin (ANN) expression was up-regulated in ..
  45. Ramani P, Nash R, Sowa Avugrah E, Rogers C. High levels of polo-like kinase 1 and phosphorylated translationally controlled tumor protein indicate poor prognosis in neuroblastomas. J Neurooncol. 2015;125:103-11 pubmed publisher
    ..PLK1 phosphorylates the translationally controlled tumor protein (TCTP)...
  46. Wang L, Tang Y, Zhao M, Mao S, Wu L, Liu S, et al. Knockdown of translationally controlled tumor protein inhibits growth, migration and invasion of lung cancer cells. Life Sci. 2018;193:292-299 pubmed publisher
    To investigate the role of translationally controlled tumor protein (TCTP) in lung cancer development. A549 and HCC827 cells were transfected with shRNA specifically targeting TCTP mRNA...
  47. Zheng J, Chen Y, Li Z, Cao S, Zhang Z, Jia H. Translationally controlled tumor protein is required for the fast growth of Toxoplasma gondii and maintenance of its intracellular development. FASEB J. 2018;32:906-919 pubmed publisher
    b>Translationally controlled tumor protein (TCTP) is a highly conserved, multifunctional protein that has been implicated in a range of cell physiologic processes, especially cell growth and development...
  48. Xoconostle Cazares B, Ruiz Medrano R. Structure-Function Relationship of TCTP. Results Probl Cell Differ. 2017;64:47-68 pubmed publisher
    The translationally controlled tumor protein (TCTP) is a small, multifunctional protein found in most, if not all, eukaryotic lineages, involved in a myriad of key regulatory processes...
  49. Piram M, Koné Paut I. [Recurrent fevers in childhood]. Presse Med. 2015;44:1266-75 pubmed publisher
    ..plus acute features of inflammation starting during childhood with family history are the main clues for suspecting HRF. Their common associated complication is AA amyloidosis...
  50. Chen K, Chen S, Huang C, Cheng H, Zhou R. TCTP increases stability of hypoxia-inducible factor 1? by interaction with and degradation of the tumour suppressor VHL. Biol Cell. 2013;105:208-218 pubmed publisher
    The translationally controlled tumour protein (TCTP) plays an important role in maintaining cell proliferation and its high expression is associated with many tumours...
  51. Bommer U, Vine K, Puri P, Engel M, Belfiore L, Fildes K, et al. Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin. Cell Commun Signal. 2017;15:9 pubmed publisher
    Translationally controlled tumour protein TCTP is an anti-apoptotic protein frequently overexpressed in cancers, where high levels are often associated with poor patient outcome...
  52. de Carvalho M, Acencio M, Laitz A, de Araújo L, de Lara Campos Arcuri M, do Nascimento L, et al. Impacts of the overexpression of a tomato translationally controlled tumor protein (TCTP) in tobacco revealed by phenotypic and transcriptomic analysis. Plant Cell Rep. 2017;36:887-900 pubmed publisher
    ..The translationally controlled tumor protein (TCTP) is a multifaceted and highly conserved eukaryotic protein...
  53. Metcalfe M, Ferguson J, Li R, Xiao L, Guo C, Czerniak B, et al. Impact of High-risk Features and Effect of Neoadjuvant Chemotherapy in Urothelial Cancer Patients with Invasion into the Lamina Propria on Transurethral Resection in the Absence of Deep Muscle Invasion. Eur Urol Focus. 2017;3:577-583 pubmed publisher
    ..We identified 336 patients with a median follow-up of 130 mo. Of these, 159 (47%) had no HRF, 140 (41.5%) had one HRF, and 37 (11%) had ≥2 HRFs...
  54. Bruckner F, Xavier A, Cascardo R, Otoni W, Zerbini F, Alfenas Zerbini P. Translationally controlled tumour protein (TCTP) from tomato and Nicotiana benthamiana is necessary for successful infection by a potyvirus. Mol Plant Pathol. 2017;18:672-683 pubmed publisher
    Translationally controlled tumour protein (TCTP) is a ubiquitously distributed protein in eukaryotes, involved in the regulation of several processes, including cell cycle progression, cell growth, stress protection, apoptosis and ..
  55. Lu F, Wang Y, Zhang J, Chen H, Yuan Z. Optical mapping of the dominant frequency of brain signal oscillations in motor systems. Sci Rep. 2017;7:14703 pubmed publisher
    ..neural oscillations represented by oxygenated hemoglobin measurements after the hemodynamic response function (HRF) deconvolution...
  56. Kobayashi D, Hirayama M, Komohara Y, Mizuguchi S, Wilson Morifuji M, Ihn H, et al. Translationally controlled tumor protein is a novel biological target for neurofibromatosis type 1-associated tumors. J Biol Chem. 2014;289:26314-26 pubmed publisher
    ..In this study, the novel NF1-associated protein, translationally controlled tumor protein (TCTP), was identified by integrated proteomics and found to be up-regulated via activated MAPK/..
  57. Kim H, Kim S, Pyun H, Maeng J, Lee K. Cellular uptake mechanism of TCTP-PTD in human lung carcinoma cells. Mol Pharm. 2015;12:194-203 pubmed publisher
    We reported previously that human translationally controlled tumor protein (TCTP) contains, at its NH2-terminus, a protein transduction domain (PTD), which we called TCTP-PTD, with the amino acid sequence MIIYRDLISH...
  58. Assrir N, Malard F, Lescop E. Structural Insights into TCTP and Its Interactions with Ligands and Proteins. Results Probl Cell Differ. 2017;64:9-46 pubmed publisher
    The 19-24 kDa Translationally Controlled Tumor Protein (TCTP) is involved in a wide range of molecular interactions with biological and nonbiological partners of various chemical compositions such as proteins, peptides, nucleic acids, ..
  59. Li S, Ge F. Current Understanding of the TCTP Interactome. Results Probl Cell Differ. 2017;64:127-136 pubmed publisher
    Evolutionarily conserved and pleiotropic, the translationally controlled tumor protein (TCTP) is a housekeeping protein present in eukaryotic organisms...
  60. Telerman A, Amson R. Introduction: How We Encountered TCTP and Our Purpose in Studying It. Results Probl Cell Differ. 2017;64:1-8 pubmed publisher
    In this brief introduction, we describe our encounter with TCTP. Back in 2000, we discovered TCTP in two quite different ways: first, we looked at protein partners of TSAP6 and one of them was TCTP...
  61. Senff Ribeiro A. Translationally Controlled Tumor Protein (TCTP/HRF) in Animal Venoms. Results Probl Cell Differ. 2017;64:193-200 pubmed publisher
    Proteins from TCTP/HRF family were identified as venom toxins of spiders from different genus. We have found a TCTP toxin in the venom gland of Loxosceles intermedia, a venomous spider very common in South Brazil. TCTP from L...
  62. Jankun J, Aleem A, Specht Z, Keck R, Lysiak Szydlowska W, Selman S, et al. PAI-1 induces cell detachment, downregulates nucleophosmin (B23) and fortilin (TCTP) in LnCAP prostate cancer cells. Int J Mol Med. 2007;20:11-20 pubmed
    ..treatment of cancer cells with VLHL PAI-1 downregulated nucleophosmin, while all forms of PAI-1 downregulated fortilin. These two proteins are implicated in important cellular processes (cell growth, cell cycle, malignant ..
  63. Choi S, Shin H, Yang Yen H, Lee M, Lee C, Park S, et al. Osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21. FEBS Lett. 2014;588:4026-31 pubmed publisher
    Translationally-controlled tumor protein (TCTP) plays a role in a number of cellular processes, but there is limited information about its function in cell differentiation...
  64. Seo E, Fischer N, Efferth T. Role of TCTP for Cellular Differentiation and Cancer Therapy. Results Probl Cell Differ. 2017;64:263-281 pubmed publisher
    The translationally controlled tumor protein (TCTP) is a highly conserved protein that is regulated due to a high number of extracellular stimuli. TCTP has an important role for cell cycle and normal development...
  65. Jin H, Zhang X, Su J, Teng Y, Ren H, Yang L. RNA interference‑mediated knockdown of translationally controlled tumor protein induces apoptosis, and inhibits growth and invasion in glioma cells. Mol Med Rep. 2015;12:6617-25 pubmed publisher
    b>Translationally controlled tumor protein (TCTP) is a highly conserved, growth‑associated and small molecule protein, which is highly expressed in various types of tumor cell...
  66. Langdon J, Vonakis B, MacDonald S. Identification of the interaction between the human recombinant histamine releasing factor/translationally controlled tumor protein and elongation factor-1 delta (also known as eElongation factor-1B beta). Biochim Biophys Acta. 2004;1688:232-6 pubmed
    The human recombinant histamine releasing factor (HrHRF), also known as translationally controlled tumor protein (TCTP), p23 and fortilin, has been described to have both extra- and intracellular functions...
  67. Palo T, Thaworn A, Charoenkij P, Thamsermsang O, Chotewuttakorn S, Tripatara P, et al. The Effects of Thai Herbal Ha-Rak Formula on COX Isoform Expression in Human Umbilical Vein Endothelial Cells Induced by IL-1?. Evid Based Complement Alternat Med. 2017;2017:9383272 pubmed publisher
    To investigate the modulated effects of HRF on cyclooxygenase isoform expression and its activity, using the human umbilical vein endothelial cell (HUVEC) model induced by interleukin-1 beta (IL-1?).
  68. Lee J, Rho S, Park S, Chun T. Interaction between fortilin and transforming growth factor-beta stimulated clone-22 (TSC-22) prevents apoptosis via the destabilization of TSC-22. FEBS Lett. 2008;582:1210-8 pubmed publisher
    ..The selected protein was fortilin, which has been characterized as a nuclear anti-apoptotic protein...
  69. Pinkaew D, Fujise K. Fortilin: A Potential Target for the Prevention and Treatment of Human Diseases. Adv Clin Chem. 2017;82:265-300 pubmed publisher
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    ..We recently generated a Plasmodium berghei (PbNK65) parasite that lacks a secreted factor, the histamine releasing factor (HRF) (PbNK65 hrfΔ), and induces in infected mice a self-resolving blood stage infection accompanied by ..
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